Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Dr. Muhammed Majeed: Father of Indian nutraceuticals industry- a life profile","authors":"Anju Majeed , Shaheen Majeed , Amirhossein Sahebkar","doi":"10.1016/j.jaim.2024.101074","DOIUrl":"10.1016/j.jaim.2024.101074","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"Article 101074"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentilla fulgens root extract rich in polyphenols ameliorate diabetic foot ulcers in wistar rats via regulating oxidative stress and connective tissue markers","authors":"Suman Kumar ,&nbsp;Yogesh P. Nikam ,&nbsp;Shatabdi Ghose ,&nbsp;Susankar Kushari ,&nbsp;Shailendra S. Gurav ,&nbsp;Satyendra K. Prasad ,&nbsp;Debasish Borbora ,&nbsp;Damiki Laloo","doi":"10.1016/j.jaim.2024.101075","DOIUrl":"10.1016/j.jaim.2024.101075","url":null,"abstract":"<div><div><strong>Background:</strong> <em>Potentilla fulgens</em> (Wall.) ex Hook. (Rosaceae), commonly known as ‘Bajradanti’ is native to the lower Himalayan regions inclusive of the North-East India. Traditionally, the plant is used to treat chronic ailments like diabetes and diverse wounds, including gastric and mouth ulcers, and injuries from tiger bites. <strong>Objective:</strong> This study aims to assess the efficacy of <em>P. fulgens</em> root extract rich in polyphenolics in healing diabetic foot ulcer (DFU) in rats. <strong>Methods:</strong> DFU was induced in streptozotocin-nicotinamide diabetic rat feet by open excision wound model. Rats were divided into eight groups (n = 6/group): normal, negative control, plain gel (placebo) control, 1% silver sulfadiazine, and <em>P. fulgens</em> treated with topical ethyl acetate (EAPF, 5% and 10%) and methanol extract (MEPF, 5% and 10%). The morphological, histological and various biochemical parameters associated with the wound healing process such as connective tissue repair and oxidative stress biomarkers were evaluated. <strong>Results:</strong> Topical application of EAPF 10% and MEPF 10% over 21 days significantly (<em>p</em> &lt; 0.05) reduced ulcer area in DFU rats compared to negative control. Furthermore, the extracts treated group notably (<em>p</em> &lt; 0.05) increased levels of connective tissue biomarkers (total protein, hydroxyproline, hexosamine, and hexuronic acid) and antioxidant components (SOD and GSH), while significantly (<em>p</em> &lt; 0.05) decreasing levels of lipid peroxidation (LPO) in foot tissue homogenate. Histological analysis of rats treated with the extracts revealed significant evidence of tissue repair, characterised by enhanced epithelial and collagen formation, along with decreased polymorphonuclear infiltration and edema. <strong>Conclusion:</strong> In summary, treatment with EAPF 10% significantly improved foot ulcers by modulating oxidative stress and connective tissue biomarkers in DFU animals.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"Article 101075"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An experimental and computational approach to evaluate the antidiabetic activity of Commiphora wightii gum extract","authors":"Shalini Jain ,&nbsp;Mukesh Kumar Sharma ,&nbsp;Nidhi Gupta ,&nbsp;Jivanage Anirudh ,&nbsp;Hemanth Naick Banavath ,&nbsp;Sreemoyee Chatterjee","doi":"10.1016/j.jaim.2024.101038","DOIUrl":"10.1016/j.jaim.2024.101038","url":null,"abstract":"<div><h3>Background</h3><div>Plant formulations with antidiabetic and antioxidant properties have recently gained popularity due to their lower cost and lesser side effects. Guggul gum is one such formulation that is extensively being used to cure various ailments.</div></div><div><h3>Objective</h3><div>The present study was designed to explore the antioxidant and antidiabetic properties of the aqua-ethanolic Guggul gum extract (GE) from <em>Commiphora wightii</em> using <em>in silico</em> studies and <em>in vitro</em> assays.</div></div><div><h3>Methods</h3><div>Gas Chromatography Mass Spectroscopy (GCMS) identified compounds were docked to the Human pancreatic α-amylase (HPA, PDB ID: <span><span>1HNY</span><svg><path></path></svg></span>) for <em>in silico</em> studies to predict the inhibition. Molecular dynamics simulations (MDS) were performed using GROMACS for 100 ns. The inhibition of the enzyme was further evaluated at <em>in vitro</em> level to show the compounds' hypoglycemic role.</div></div><div><h3>Results</h3><div>The extract showed a good amount of phenolic (5.14 ± 0.011 mg), flavonoid (0.66 ± 0.023 mg) and terpenoid (1.08 ± 0.018 mg) content along with a promising free radical scavenging activity of 41.96 ± 4.02%. In the <em>in silico</em> studies, 3 out of 6 GCMS-identified bioactive compounds showed permissible values of bioavailability properties suggesting them as a potential candidate for antidiabetic drugs. Similarly, in molecular docking studies, 3 compounds showed more binding energy than the standard drug acarbose indicating better inhibition. MDS studies showed <em>Compound 4</em> (Diisooctyl phthalate), was the most stable with the lowest root mean square deviation (RMSD) and root mean square fluctuation (RMSF) values, a consistent radius of gyration (Rg), and stable solvent accessible surface area (SASA). This was further confirmed by <em>in vitro</em> analysis where the pancreatic α-amylase inhibitory activity of the extract and the standard drug (acarbose) were comparable at an IC₅₀ value of 4.17 ± 1.26 mg/mL and 3.69 ± 0.89 mg/mL respectively.</div></div><div><h3>Conclusion</h3><div>The results demonstrated GE as a potential alternative to commercial antidiabetic drugs. Out of the major 6 GCMS-identified compounds, <em>Compound 4</em> showed the most stable conformation during MDS studies. However, the isolation of the identified compounds could be done in the future for <em>in vivo</em> studies.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"Article 101038"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Add on effect of Whole System Ayurveda protocol in suboptimal controlled Primary Hypothyroidism - A randomized controlled trial","authors":"Vivek ,&nbsp;Arun Chougale ,&nbsp;Himanshu Joshi ,&nbsp;Basavaraj R. Tubaki","doi":"10.1016/j.jaim.2024.101052","DOIUrl":"10.1016/j.jaim.2024.101052","url":null,"abstract":"<div><h3>Background</h3><div>Primary hypothyroidism (PH) is a common chronic life style disorder. Whole system <em>Ayurveda protocol</em> on PH <em>(WSAPH)</em> is explored for it's possible complimentary role in the management of suboptimal controlled PH on stable levothyroxine therapy.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy of whole system Ayurveda protocol on Primary hypothyroidism with suboptimal response to stable levothyroxine therapy.</div></div><div><h3>Material and methods</h3><div>Study was a randomized controlled trial. Total 46 known patients of suboptimal response to stable levothyroxine therapy, age group 20–60 years of either sex participated in the study. They were randomly placed in two groups, Group KG received Kanchanara guggulu two tablets of 500 mg each, thrice a day with water and group WSAPH was on whole system Ayurveda protocol for primary hypothyroidism (WSAPH). Interventions were for 60 days. Assessments were done through various parameters like Thyroid profiles (TSH, T3, T4, Free T4), Weight, BMI, Skin fold thickness (SFT), Body fat index (BFI), Waist hip ratio (WHR), Lipid profile, Zulewskis clinical score for hypothyroidism (ZUL), WHO Quality of Life- BREF (WHOQOL-BREF), Clinical Global Improvement scales (CGI). Clinical assessments were done on every 15th day and biochemical were done before and after interventions.</div></div><div><h3>Results</h3><div>Study showed that WSAPH group produced significant outcome improvement compared to KG group in TSH (p = 0.02), weight (p = 0.02), SFT (p = 0.04), BFI (p = 0.01), WHOQOL-BREF (p = 0.004) and ZUL (p = 0.02). Both the group showed improvements in BMI, WHR, BFI, SFT, WHOQOL-BREF, ZUL, CGI scales. Effect size was medium in TSH, weight, BFI, SFT and ZUL.</div></div><div><h3>Conclusion</h3><div><em>WSAPH</em> was effective in management of PH and normalized TSH and ZUL scores in patients with suboptimal response to stable levothyroxine therapy. Further studies are needed.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"Article 101052"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promotion of cellular differentiation and DNA repair potential in brain cancer cells by Shankhpushpi, (Clitoria ternatea L.) with rasayana properties in vitro","authors":"Keshava Prasad ,&nbsp;Kothanahalli S. Raghu ,&nbsp;Swathi Maruthiyodan ,&nbsp;Renu Wadhwa ,&nbsp;Sunil C. Kaul ,&nbsp;Kapaettu Satyamoorthy ,&nbsp;Kanive Parashiva Guruprasad","doi":"10.1016/j.jaim.2024.101050","DOIUrl":"10.1016/j.jaim.2024.101050","url":null,"abstract":"<div><h3>Background</h3><div>Brain ageing is accompanied by the diminution of neuronal plasticity, which is correlated with the inability to respond to loss of memory, various stress-induced stimuli, and increased risk of neurodegenerative disorders. In the recent past, plant based herbal medicines are of interest over synthetic drugs for therapeutic purposes due to lower side effects. The Indian traditional medicine Ayurveda describes several herbal remedies, such as rasayana (elixirs for rejuvenation), to treat many age-related diseases. Medhya rasayana (brain elixir) is a class of rasayana used for its nootropic functions, such as enhancement of memory and intellect, in addition to promoting normal health. <em>Clitoria ternatea</em> L. is one such plant used in the preparation of medhya rasayana.</div></div><div><h3>Objective</h3><div>To investigate the neuronal differentiation and DNA repair potential of Shankhpushpi (<em>Clitoria ternatea</em> L.) in neuroblastoma cells.</div></div><div><h3>Materials &amp; methods</h3><div>The effect of <em>Clitoria ternatea</em> L. on neuronal cell differentiation, DNA repair (base excision repair, comet, γH2AX immunostaining assays), autophagy by cadaverine uptake and mitochondrial functions by fluorescent dye staining through flow cytometry were evaluated.</div></div><div><h3>Results</h3><div>The results revealed that <em>Clitoria ternatea</em> L. enhanced DNA repair and mitochondrial membrane potential and reduced autophagy and reactive oxygen species (ROS) in IMR-32 neuroblastoma cells. Treatment of IMR-32 neuroblastoma and C6 glioblastoma cells with shankhpushpi induced neuronal differentiation and exhibited markers such as MAP2, Mortalin and GFAP.</div></div><div><h3>Conclusion</h3><div>Neurobiological pathways and molecular mechanisms influenced by rasayana herb shankhpushpi suggests its therapeutic potential for neurodegenerative diseases.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"Article 101050"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charak Samhita Online Edition- A step towards globalization of Ayurveda","authors":"Yogesh S. Deole ,&nbsp;Gopal Basisht","doi":"10.1016/j.jaim.2024.101058","DOIUrl":"10.1016/j.jaim.2024.101058","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"Article 101058"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of chronic non-healing venous stasis ulcer through Siddha intervention - a case report","authors":"Nikil Niva John Raja,&nbsp;Hema Nandhini Devi Veluchamy,&nbsp;Muthu Vignesh Sivanan","doi":"10.1016/j.jaim.2024.101034","DOIUrl":"10.1016/j.jaim.2024.101034","url":null,"abstract":"<div><div>Venous stasis ulcer is a chronic vascular disease and majorly occurred in lower limbs. Recurrence of ulcer in lower extremities are common in venous stasis ulcer. A 65 years old male patient had a symptoms of non-healing ulcer in right leg nearby right ankle joint in more than three months and associated with itching, hyperpigmentation and pain. A patient had a previous history of Deep Vein Thrombosis. Significant healing in wound observed under the siddha medication such as combination of Siddha Sastric chooranam (<em>Parangipattai chooranam, Palagarai parpam, Irunelli Karpam, Sangu parpam</em>) and <em>Vallarai</em> tablet for internal medication and <em>Triphala chooranam</em> as external medication for washing wounds whereas, <em>Maththan thylam</em> is applied for wound dressing. No recurrence of ulcer was observed after a follow-up of 4 months period. This case report depicted the management of chronic ulcer through Siddha medicines.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 101034"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Structural and Thermal properties of Badarashma Pishti","authors":"Chandrashekhar Y. Jagtap ,&nbsp;Vaibhav Charde ,&nbsp;Hemant Rawat ,&nbsp;Ganesh Dane ,&nbsp;Ashwini Kumar Mishra ,&nbsp;Ch. Venkata Narasimhaji ,&nbsp;Bhagwan S. Sharma ,&nbsp;Shruti Khanduri ,&nbsp;Ravindra Singh ,&nbsp;Narayanam Srikanth ,&nbsp;Rabinarayan Acharya","doi":"10.1016/j.jaim.2024.100989","DOIUrl":"10.1016/j.jaim.2024.100989","url":null,"abstract":"<div><h3>Background</h3><div><em>Lapis judaicus</em>, or Jews stone (<em>Badarashma</em>), has been used in treating kidney and bladder stones since ancient times by Ayurvedic and Unani medicinal practitioners. A limited number of studies have been carried out using Ayurvedic preparations derived from gems or precious stones that were used traditionally. In Ayurveda, Rasa Shastra includes the fabrication of <em>Bhasmas</em> and <em>Pishti</em>.</div></div><div><h3>Objective</h3><div>This study aimed to prepare and characterize <em>Badarashma Pishti</em> formulation (<em>Lapis j</em><em>udaicus</em> microparticles) and investigate its structural and thermal properties.</div></div><div><h3>Materials and methods</h3><div>The microparticles were prepared by subjecting purified powder of <em>L</em><em>apis judaicus</em> to a wet levigation (<em>Bhavana</em>) process. Characterizations were done using Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), thermo-gravimetry analysis (TGA), energy-dispersive X-ray (EDAX) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM) analysis. Physicochemical characterization, elemental analysis, particle size distribution study, and identification of heavy metals were also performed.</div></div><div><h3>Results</h3><div>A standard operating procedure was developed to formulate <em>Badarashma Pishti</em>. The obtained microparticles were irregularly shaped with a size of 4.290 ± 0.472 μm, confirmed in SEM images. The FTIR and XRD of prepared <em>Badarashma Pishti</em> samples revealed the presence of calcite, quartz, and aragonite minerals. The results of EDAX also confirmed the presence of Ca, Mg, O, and Si elements.</div></div><div><h3>Conclusion</h3><div>The proposed study results reveal great insights for determining the authenticity, purity, and standardization parameters of inorganic mineral drugs, proving to be a useful delivery system for treating renal calculi.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 100989"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of a patient of hypertriglyceridemia with Benign Prostate Hyperplasia through integrative medicine - A case report","authors":"K. Santhosh","doi":"10.1016/j.jaim.2024.100991","DOIUrl":"10.1016/j.jaim.2024.100991","url":null,"abstract":"<div><div>This is a case report of a 60-year-old male, who was a patient of Benign Prostate Hyperplasia since 2019, diagnosed as having Hypertriglyceridemia (Serum Triglycerides-839 mg/dL) after routine screening in a Diagnostic Laboratory. Although these were two distinct disease entities, Charaka Samhita's concept of <em>Srotas</em> was taken into consideration for treatment, and drugs that reduced both Serum Triglyceride levels and Lower Urinary Tract Symptoms (LUTS) of BPH were chosen. <em>Varanadi Kashaya</em> and <em>Shilajitvadi Bati</em> were given as medicines and after one month of follow-up, Serum Triglycerides decreased to 283 mg/dL, and improvement in the form of reduction of hesitancy during urination was appreciated by the patient. Over the course of the next one and a half years, the patient's serum triglycerides level was monitored with the same two medicines, along with the addition of <em>Vastyamayantaka Ghritam</em> and improvement was seen at each follow-up appointment. Therefore, in people with obesity and disorders of urinary system, the medicines which act on the kidneys can be selected, since they serve as the common origin for <em>Medovaha Srotas</em> and <em>Mutravaha Srotas</em>.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 100991"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term disease-free survival of a patient of acute myeloid leukemia with superior vena cava syndrome grade 2 with adjunct Ayurvedic treatment: A case report","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Arvind Kulkarni,&nbsp;Vasanti Godse,&nbsp;Shrinivas Datar,&nbsp;Swapna Kulkarni,&nbsp;Sushama Bhuvad,&nbsp;Anita Shingte,&nbsp;Sandeep Chavan","doi":"10.1016/j.jaim.2024.101027","DOIUrl":"10.1016/j.jaim.2024.101027","url":null,"abstract":"<div><div>Long-term disease-free survival (DFS) of 19 years and 8 months is achieved in an Indian male young patient with Acute Myeloid Leukemia (AML) with a grade 2 Superior Vena Cava (SVC) syndrome treated with chemotherapy and adjunct personalized Ayurvedic treatment with medicines having antipyretic (<em>Jwaraghna</em>), reduces inflammation and swelling (<em>Shothaghna</em>) and rejuvenating (<em>Rasayana</em>) properties and effective in anemia (<em>Pandu</em>) and respiratory diseases (Diseases of <em>pranavaha srotasa</em>)</div><div>In January 2002, this patient was diagnosed with Pulmonary Kochs and Anti Koch's treatment was given for 6 months. However, due to persistent low-grade fever and supra clavicular lymph node enlargement, he was further investigated with X-Ray Chest in July 2002 revealing mediastinal lymphadenopathy with Right Costophrenic angle pleural effusion. (Grade 2 SVC syndrome). Histopathological report of Supraclavicular Lymph node confirmed the hematolymphoid possibility of acute leukemia. He underwent an aggressive course of chemotherapy from August 2002 to October 2003. Initially four Cycles of Oral Chemotherapy (Tab. Mercaptopurine 100 mg with Cap. Etoposide 100 mg) were administered instead of IV Chemo during the period of August 08, 2002 to December 02, 2002 due to financial problem of patient. Thereafter he was treated with two cycles of consolidation with Inj. Cytarabine (high dose) from December 05, 2002 to January 31, 2003 followed by four cycles of maintenance chemotherapy (Inj. Daunomycin 90 mg and Cytarabine high dose 190 mg) from February 06, 2003 to May 07, 2003 and again four cycles of oral chemotherapy from May 26, 2003 to October 07, 2003 (Tab 6 TG (40 mg) 2 tablets and Cap Posid 100 mg OD for 21 days)</div><div>The patient started Oral Ayurvedic Medicines (OAM) in August 2002 i.e. at the beginning of chemotherapy which consisted of 3 sets of herbo-mineral Ayurvedic medicines to minimize the side effects of chemotherapy, prevent anemia, and bleeding disorders, strengthen the respiratory system as well as boost immunity to prevent disease recurrence. Since his all pathological parameters were normal and his quality of life was improved significantly, Ayurvedic treatment was stopped in Nov 2008 and he was kept under follow-up. He is asymptomatic without any disease recurrence to date.</div><div>In this case of AML having grade 2 SVC syndrome with unfavorable prognostic factors as male sex, diagnosis at 24 yrs. age, low socioeconomical status and also with limited life expectancy, a long-term DFS of 19 years and 8 months is reported. It has been achieved by an integrative approach of chemotherapy and personalized adjunct Ayurvedic treatment consisting oral herbo-mineral medicines.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 101027"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}