Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Potential anticancer activity of Shulva Yoga, a herbo-metallic compound, in loss of scrib induced cancer in Drosophila melanogaster","authors":"Shiwakshi Sharma ,&nbsp;Namrata Joshi ,&nbsp;Saripella Srikrishna ,&nbsp;Konduru Rama Chandra Reddy ,&nbsp;Partha Pratim Manna ,&nbsp;Manoj Kumar Dash ,&nbsp;Pankaj Kumar ,&nbsp;Remya Jayakumar ,&nbsp;Jyotsna Singh","doi":"10.1016/j.jaim.2025.101292","DOIUrl":"10.1016/j.jaim.2025.101292","url":null,"abstract":"<div><div><strong><em>Background:</em></strong>The worldwide burden of cancer is illustrated by the 10.0 million fatalities (World Health Organization, 2021) and the 19.3 million incidence of new cases as reported in the GLOBOCAN data. The transparency to sensitiveness of chromosomal aberrations and the consequent responses in epithelial cancer quotients collectively explains the need of tumor exploration in Drosophila models.</div><div><strong><em>Objective:</em></strong> The reciprocation of a traditional herb-mineral combination <em>Shulva Yoga</em> (SY) in epithelial tumour microenvironment has been fundamentally assessed here.</div><div><strong><em>Material and methods</em></strong><em>:</em>Classically incinerated copper ash were mixed for levigation with madyantika (<em>Lawsonia inermis</em>L.), punarnava (<em>Boerhaavia diffusa</em>L.) and <em>meshshringi</em>[<em>Gymnema sylvestr</em>e (Retz.) Schult.] leaves. The in-vitro analysis of MTT and AnnexinV/PI staining were applied on four different cell lines (DL, JE6.1, MCF-7,&amp; WRL-68) with SY. The in-vivo analysis was initiated with loss of scribble (cell polarity protein) in wing imaginal disc of Drosophila melanogaster for epithelial carcinoma induction. The dose determination was followed with pupal lethality assessment and anti-oxidant levels. The Phalloidin/F-actin filament, DAPI and Immunostaining were further implied.</div><div><strong><em>Results:</em></strong>The IC50 of SY treated DL, JE6.1, MCF-7 and WRL-68 cells at 24 hours was 28.25±1.5 μg, 27.27±1.6 μg, 37.59±1.9 μg, 15.92±2.5 μg respectively. The dosedependent range of 0.01 mg/ml to 0.2 mg/ml exhibited the features of early and late apoptosis after 24hrs with AnnexinV/PI stain. SY showed early pupal rescue, preservation of Actin filaments, downregulation of MMP 1and cyclin-E in comparison to the untreated. There was surge of the SOD and catalase levels, whereas LPO content depressed.</div><div><strong><em>Conclusion:</em></strong>SY might induce apoptosis in tumour cells with counter mechanisms on angiogenesis, proliferation and metastasis in Drosophila model. Gene amplification, protein specificity, etc are the future prospects of present work.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101292"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral administration of osimertinib mesylate induced multiple peripheral neuropathy of a non-small-cell lung cancer patient and treated with traditional Chinese medicine - A case report","authors":"Xiange Huang ,&nbsp;Hegen Li ,&nbsp;Ziming Li ,&nbsp;Yilin Yao","doi":"10.1016/j.jaim.2025.101225","DOIUrl":"10.1016/j.jaim.2025.101225","url":null,"abstract":"<div><div>Osimertinib mesylate (OM) is a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) for the targeted treatment of non-small-cell lung cancer (NSCLC). To date, some adverse effects of OM (such as rhabdomyolysis, severe rash, etc.) have been reported in clinic, but no cases of OM-induced multiple peripheral neuropathy (MPN) have been documented. Here we report a rare case about oral administration of OM-induced MPN in a NSCLC patient and its treatment with traditional Chinese medicine (TCM) decoction. After taking OM orally to treat NSCLC for 2 months, a 70-year-old man experienced MPN symptoms including numbness in hand and foot, weakness in both lower limbs, limited mobility, and eventually the loss of the ability to stand and walk. Meanwhile, other known causes of MPN were ruled out. His symptoms did not improve after 24 days of discontinuing oral administration of OM. Subsequently, he received daily oral TCM decoction based on syndrome differentiation. One month later, his symptoms of MPN were relieved and the Total Neuropathy Score (TNS) was significantly reduced. He was able to stand and walk with the aid of a walker. The use of dialectical TCM decoction is a feasible treatment protocol to alleviate and even eliminate MPN symptoms. Further study is needed to investigate the mechanisms and preventive strategies of OM-induced MPN.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101225"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for a centralized repository of standardized validated scales and disease gradation tools for clinical research in Ayurveda","authors":"Urmila J. Shirke ,&nbsp;Payal P. Wavhal","doi":"10.1016/j.jaim.2025.101271","DOIUrl":"10.1016/j.jaim.2025.101271","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101271"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an integrated Yoga module on clinical, endocrine and metabolomic outcomes in polycystic ovarian syndrome","authors":"Deepika Kumari ,&nbsp;Reeta Mahey ,&nbsp;Neena Malhotra ,&nbsp;Rima Dada","doi":"10.1016/j.jaim.2025.101294","DOIUrl":"10.1016/j.jaim.2025.101294","url":null,"abstract":"<div><div>Polycystic ovarian syndrome (PCOS) affects 5–20 % of women of reproductive age, with reproductive, metabolic, endocrine, and psychological consequences. Lifestyle interventions such as yoga provide safe, low-cost, and sustainable therapy. In this study, 25 women with PCOS underwent a 12-week yoga program (<em>Asanas</em>, <em>Pranayama,</em> Meditation) without concurrent therapy. Yoga improved menstrual regularity, normalized hormonal and metabolomic profiles. Biochemical analysis revealed reduced oxidative stress, enhanced mitochondrial function, improved insulin signaling, and decreased inflammation. Hormonal assays showed reduced luteinizing hormone (LH), anti-Müllerian hormone (AMH), dihydrotestosterone (DHT), and testosterone, with increased follicle-stimulating hormone (FSH), estradiol, and sex hormone-binding globulin (SHBG). Metabolomic improvements included reductions in glucose, fructose, <span>d</span>-ribose, xanthine, cholesterol, triglycerides, and body weight. These findings highlight yoga's potential to target core PCOS pathophysiology and support its use as a cost-effective, non-pharmacological, and sustainable therapy inn management of PCOS.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101294"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tribulus terrestris L. confers protection against hypoxia induced pulmonary hypertension via regulation of HIF/ NF-κB signalling pathway","authors":"Yashesvi Ambardar,&nbsp;Sheema Wazib,&nbsp;Sher Afghan,&nbsp;Md Iqbal Alam","doi":"10.1016/j.jaim.2025.101296","DOIUrl":"10.1016/j.jaim.2025.101296","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary hypertension (PH) is a fatal cardiopulmonary disorder driven by hypoxia-induced vascular remodeling. The hypoxic pulmonary vasoconstriction (HPV) and increased pulmonary vascular resistance leads right ventricular failure and ultimately death. Limited therapies and poor prognosis demand novel interventions. <em>Tribulus terrestris</em> L., renowned for antioxidant and anti-inflammatory effects, may modulate various pathways of hypoxia induced pulmonary hypertension pathogenesis.</div></div><div><h3>Objective</h3><div>This study examines potential of <em>T. terrestris</em> to counter hypoxia-induced PH in a rodent model via HIF–NF-κB signalling.</div></div><div><h3>Material and methods</h3><div>Thirty male Wistar rats were randomly undertaken, 6 rats were utilized for standardization of drug dose (<em>T. terrestris)</em> and remaining 24 were divided into 4 groups with 6 animals in each group as normal control, pulmonary hypertension due to intermittent hypoxia, pulmonary hypertension due to intermittent hypoxia + Tadalafil drug, pulmonary hypertension due to intermittent hypoxia + <em>T. terrestris</em> 250 mg/kg. Right ventricular systolic pressure (RVSP), serum levels of reactive oxygen species (ROS), nitric oxide (NO),inducible nitric oxide synthase (iNOS) and inflammatory markers-hypoxia inducible factor-1α (HIF-1α), nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in all the groups were analysed.</div></div><div><h3>Results</h3><div>Administration of crude <em>T. terrestris</em> extract to hypoxic pulmonary hypertensive rats significantly reduced RVSP, ROS, NO, iNOS, and inflammatory markers. No significant difference in therapeutic outcomes was observed between <em>T. terrestris</em> and tadalafil treatment groups.</div></div><div><h3>Conclusion</h3><div><em>T. terrestris</em> exhibits biochemical and hemodynamic changes associated with marked improvement in pulmonary hypertension indicating strong anti-oxidative, anti-inflammatory, and anti-angiogenic effects. This is the first study to report the protective effects of <em>T. terrestris</em> against hypoxic pulmonary hypertension.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101296"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel effective treatment for skin abscess using traditional Chinese herbal medicine: a case series","authors":"Liang-Jun Lu ,&nbsp;Xin-Yi Lu ,&nbsp;Xiu-Zu Song ,&nbsp;Ai-E Xu","doi":"10.1016/j.jaim.2025.101285","DOIUrl":"10.1016/j.jaim.2025.101285","url":null,"abstract":"<div><div>Skin abscess is a common bacterial infection of the skin and soft tissues. Conventional treatment typically involves incision and drainage after pus formation, which may lead to prolonged healing and surgical scarring. Traditional Chinese Medicine (TCM) has extensive experience in treating infectious diseases with the potential for rapid recovery and minimal scarring; however, international literature on its efficacy remains limited. We present three cases of skin abscess successfully treated with an oral modified Xian Fang Huo Ming Yin (XFHMY) decoction based on syndrome differentiation.</div></div><div><h3>Case 1</h3><div>A 29-year-old male presented with a painful, swollen plaque on the left upper back persisting for over two weeks.</div></div><div><h3>Case 2</h3><div>A 12-year-old girl with a red, swollen mass on the left waist for more than 10 days.</div></div><div><h3>Case 3</h3><div>A 35-year-old male with a painful, erythematous plaque on the inner right upper arm for half a month.</div><div>After 5–7 days of TCM treatment, all abscesses resolved completely without significant scarring, and only mild hyperpigmentation or depression remained. These findings suggest that TCM, particularly modified XFHMY, may serve as an effective non-invasive alternative therapy for skin abscesses.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101285"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signaling pathways and molecular mechanisms of lupeol in colorectal cancer: A comprehensive review","authors":"Mohd Asad Farooqi,&nbsp;Kantrol Kumar Sahu","doi":"10.1016/j.jaim.2025.101270","DOIUrl":"10.1016/j.jaim.2025.101270","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is a serious worldwide health concern associated with chronic inflammation and dysregulation of numerous signaling pathways, including IL-6/STAT3, NF-κB, COX-2/PGE2, and IL-23/Th17. These pathways aid in tumour development and progression by increasing the manufacture of inflammatory mediators, anti-apoptotic gene expression, cell proliferation, and angiogenesis. Lupeol, a naturally occurring lupine-type pentacyclic triterpenoid, has sparked widespread interest due to its several pharmacological qualities, which include antioxidant, anti-inflammatory, anticancer, and antibacterial capabilities. Despite its enormous medicinal promise, low water solubility and bioavailability have hampered its clinical use. Recent advances in nano-based delivery systems and the invention of lupeol derivatives have increased its bioavailability and bioactivity, making it a promising candidate for CRC treatment. This study seeks to inspire additional research into lupeol's significance as a nutraceutical intervention in CRC by integrating current knowledge and investigating novel techniques to increase its clinical efficacy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101270"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential benefits of Ayurveda in Duchenne muscular Dystrophy: A case based analysis","authors":"Manchal Shivappa Puja,&nbsp;Kothanath Bhaskaran Jyothy,&nbsp;Varuni Kulkarni,&nbsp;S. Srihari","doi":"10.1016/j.jaim.2025.101272","DOIUrl":"10.1016/j.jaim.2025.101272","url":null,"abstract":"<div><div>Duchenne Muscular Dystrophy is a debilitating X-linked genetic disorder that manifests in early childhood with progressive muscle weakness, loss of ambulation, and ultimately, respiratory and cardiac failure resulting in premature mortality. A nine-year-old male patient presented with the inability to stand and ambulate without assistance, which had persisted since six years of age. He had been previously diagnosed with Duchenne Muscular Dystrophy, and his parents provided the relevant diagnostic documents. The patient exhibited weakness in the lower extremities, poor appetite, irregular bowel habits, and irritability. The clinical manifestations were evaluated from an Ayurvedic perspective, and a corresponding treatment plan was subsequently devised. The treatment regimen spanned 4 months, consisting of 6 sessions with an interval of 15–20 days between each clinical visit. The therapeutic approach encompassed major interventions such as external and internal Swedana, Basti, and oral medications. Concurrently, internal medications and appropriate dietary modifications were incorporated. The internal medications included herbs like <em>Sida cordifolia</em> L, <em>Withania somnifera</em>, <em>Terminalia chebula</em> Retz, <em>Bacopa monneri</em>, and <em>Zingiber officinale</em> Roxb. Additional herbs with proven Immunomodulatory, Antioxidant, and Anti-Inflammatory properties were also utilized. Physiotherapy was continued as part of the overall management strategy.</div><div>Following the third treatment session, the child exhibited the ability to stand with the support of a cot, grasp and throw a stone - abilities that were not previously observed prior to the therapies. Additionally, by the end of the first month, improvements were noted in the patient's appetite and bowel habits. The comprehensive Ayurvedic approach, when combined with physiotherapy, demonstrated enhancements in symptoms such as relief from constipation, the capacity to stand with cot support, subtle changes in the upper limb muscle tone, and an overall enhancement in the child's quality of life. This study highlights the potential of Ayurveda as a complementary approach to conventional treatment.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101272"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of an LCMS method for stability evaluations of piperine in Murchita utpalashatpala ghrita","authors":"Ashutosh Gupta ,&nbsp;Moumita Saha ,&nbsp;Abhishek Ravindra Malandkar ,&nbsp;Aditya Dev Rajora ,&nbsp;Shivani Kunkalienkar ,&nbsp;J. Dinesh Nayak ,&nbsp;Sudheer Moorkoth","doi":"10.1016/j.jaim.2025.101286","DOIUrl":"10.1016/j.jaim.2025.101286","url":null,"abstract":"<div><h3>Background</h3><div><em>Utpalashatphala ghrita</em> (USG) is a traditional ayurvedic medicine containing piperine as its main chemical constituent responsible for the activity. <em>Murchita</em> is an ayurvedic process to detoxify and purify the lipids (ghee, oil). It involves heating ghee with specific ayurvedic ingredients for a specified duration and temperature. It is essential to understand the stability of piperine during and after the murchita process.</div></div><div><h3>Objective</h3><div>The objective of this study was to develop and validate an LCMS method to assess the stability of piperine after the <em>murchita</em> process.</div></div><div><h3>Method</h3><div>LCMS system with electrospray ionization and ion-trap as the analyser was used to estimate the piperine content. Analysis was carried out in the multiple reaction monitoring (MRM) mode. Chromatographic mobile phase composed of a mixture of 55 % formic acid (0.1 %) in Milli-Q water (pH 3) and 45 % methanol. The LC-MS method was validated as per ICH Q2 (R2) guidelines. Stability of <em>ghrita</em> was assessed at various stability conditions.</div></div><div><h3>Result</h3><div>The developed LCMS method was accurate, precise and linear over a range of 0.5–32 μg/mL. LOQ of the method was 125 ng/mL and the run time was 10 min. <em>Utpalashatphala</em> ghrita (USG) and <em>Murchita- Utpalashatphala ghrita</em> (M-USG) were prepared as specified under <em>Bhaishajya Ratnavali</em>. Our study revealed that the murchita process degraded piperine by 26 %. However, the stability of piperine was found to be better in the murchita ghrita (M -USG), compared to the unprocessed USG.</div></div><div><h3>Conclusion</h3><div>Study effectively demonstrated that the <em>murchita</em> process enhanced the long-term stability of piperine.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101286"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Delhi Declaration on Traditional Medicine: Outcome of the Second WHO Global Summit on Traditional Medicine (2025)","authors":"","doi":"10.1016/j.jaim.2026.101328","DOIUrl":"10.1016/j.jaim.2026.101328","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 1","pages":"Article 101328"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}