Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Duration of fermentation affects microbiome composition and biological activity of an Indian traditional formulation – Panchagavya","authors":"Gemini Gajera ,&nbsp;Snehal Funde ,&nbsp;Hanmanthrao Palep ,&nbsp;Vijay Kothari","doi":"10.1016/j.jaim.2023.100880","DOIUrl":"https://doi.org/10.1016/j.jaim.2023.100880","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed at investigating whether the duration of fermenting <em>Panchagavya</em> (PG) preparation in copper vessel affects its biological activity and microbiome composition.</p></div><div><h3>Materials and methods</h3><p>Prophylactic potential of PG against bacterial infection was assessed through an <em>in vivo</em> assay employing the nematode worm <em>Caenorhabditis elegans</em> as a model host. Bacterial diversity of the PG samples was revealed through metagenomic analysis.</p></div><div><h3>Results</h3><p>Duration of fermentation was found to affect biological activity as well as microbiome composition of the PG samples. PG-samples fermented ≥60 min lost their prophylactic potential, and develop anthelmintic activity. Bacterial phyla whose relative abundance was significantly different between the prophylactic and anthelmintic PG samples were Planctomycetota, Proteabacteria, Bacteroidota, Verrucomicrobiota, Patescibacteria, Acidobacteriota, Chloroflexi, Firmicutes and Campilobacterota.</p></div><div><h3>Conclusion</h3><p>This study validates the prophylactic potential of <em>Panchagavya</em> against bacterial pathogens, and shows that duration of the fermentation time while preparing PG can have profound effect on its biological activities. Biological activities of PG samples seem to have a correlation with their inherent microbial community. Metagenomic profiling can be an effective tool for standardization of PG formulations.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947623001973/pdfft?md5=724a8b8030c76d6908fe07a69da2ae9f&pid=1-s2.0-S0975947623001973-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140062487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory effect of Unani polyherbal formulation - Tiryaq Wabai in mild to moderate COVID-19 patients – A randomized placebo-controlled clinical trial","authors":"Ansul Kumar ,&nbsp;Mohd Saif Khan ,&nbsp;Zeya Ul Haque ,&nbsp;Arpita Rai ,&nbsp;Mohammad Fazil ,&nbsp;Gulam Rabbani","doi":"10.1016/j.jaim.2024.100903","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100903","url":null,"abstract":"<div><h3>Background</h3><p>The pathogenesis of COVID-19 includes an integrated immune-inflammatory response. Modulation of host immune responses against the SARS-CoV-2 virus might be effective therapeutic management. Various Unani formulations have an immunomodulatory effect.</p></div><div><h3>Objective</h3><p>To explore the immunomodulatory effect and safety of Unani polyherbal drug (<em>Tiryaq Wabai</em>) in COVID-19 patients.</p></div><div><h3>Materials and methods</h3><p>The current study was a randomized placebo-controlled clinical trial that included 92 mild to moderate COVID-19 patients randomized into two groups. The Unani formulation <em>Tiryaq Wabai</em> (2 gm orally once a day) was used as an intervention for 45 days, while the control group received a placebo. Both groups received standard care treatment. The primary outcome was 50% increment in absolute lymphocyte count (ALC). The secondary outcome was 50% increment in mean lymphocyte percentage, CD4 cells, and CD8 cell count. The mean increase in all the above parameters has also been studied. Relevant statistical tests were used to analyze the effect.</p></div><div><h3>Results</h3><p>A statistically significant improvement in a 50% increase in ALC (p-value, 0.004), lymphocyte percentage (p-value, 0.056), CD4 (p-value, 0.005), and CD8 cell count (p-value, 0.050) was reported. Also, a significant improvement in the mean value of the lymphocyte percentage (p-value 0.0007), ALC (p-value 0.0022), CD4 cell count (p-value 0.0025), and CD8 cell count (p-value 0.0093) was observed after the treatment. One adverse event of mild grade was reported in the placebo group. The analysis of safety parameters (LFT and KFT) was normal for both groups.</p></div><div><h3>Conclusion</h3><p>In mild to moderate COVID-19 patients, <em>Tiryaq Wabai</em> effectively showed immunomodulatory activity by improving ALC count, lymphocyte percentage, CD4, and CD8 cell count.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000184/pdfft?md5=8e7c984385b2056c4a79ca79734677e7&pid=1-s2.0-S0975947624000184-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140344488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A century of ‘The science of yoga’ (1921–2021): Revival, renewal and renaissance” [J. Ayurveda Integr. Med. 14 (2023) 100613]","authors":"Ashok D.B. Vaidya,&nbsp;Rama Vaidya","doi":"10.1016/j.jaim.2024.100927","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100927","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000421/pdfft?md5=2cecf69e74ea319216052ea0346e4fd1&pid=1-s2.0-S0975947624000421-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140647455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in muscular strength, body flexibility and balance by yoɡasana and with reduced detraining effects by yoɡa breathing maneuvers: A non-randomized controlled study","authors":"Gopinath Bhowmik Bhunia,&nbsp;Uday Sankar Ray","doi":"10.1016/j.jaim.2023.100815","DOIUrl":"10.1016/j.jaim.2023.100815","url":null,"abstract":"<div><h3>Background</h3><p><em>Yoɡa</em> was reported to have the potential to improve physical fitness. Its applications are being used by common persons for wellness, but literature on the training and detraining effects of components of <em>yoga</em> is scarce.</p></div><div><h3>Objectives</h3><p>To explore the potential of different proportions of <em>yoga</em> postures (<em>Yogasana</em>) and <em>yoga</em> breathing maneuvers (YBM), consisting of <em>Pranayama</em> and <em>kriya,</em> on muscular strength, flexibility, and balance in training and detraining management.</p></div><div><h3>Methods</h3><p>ː 32 physically active male students, aged 20.5 ± 1.3 yrs, were divided into control (CG) and <em>yoga</em> group (YG). YG practiced <em>yogasana</em>, YBM, and dhyana for 45 min in each session for 6 days per week for 12 weeks. From 1st week to 6th week, they practiced <em>yogasana</em> in greater proportion. 7th week onwards YBM was inducted by increasing its duration and varieties. CG did not practice <em>yoga</em>. Back-leg strength (BLS), Hand Grip Strength (HGS), flexibility, and balance were recorded before, the 6th week and 12th weekend of training.</p></div><div><h3>Results</h3><p>ː.In YG, the pre-training value of BLS was 110.8 ± 12.6 kg. It increased (2.3 %) to 113.3 ± 11.4 kg (p &lt; 0.001) on the 6th weekend. On the 12th weekend, it further increased in lesser magnitude (0.4 %) to 113.7 ± 11 kg (p &lt; 0.05) and the pattern of improvement was the same in other parameters, but in flexibility and balance its magnitude was greater (p &lt; 0.001). CG did not show such changes.</p></div><div><h3>Conclusions</h3><p>ː <em>Yogasana</em> helps in the improvement of muscular strength, flexibility, and balance and YBM counteracts detraining effects in the absence of <em>yogasana</em>. Judiciously selected components of <em>yoga</em>/YBM may have applications in sports, occpational health and recuperative patients.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947623001328/pdfft?md5=83e058618932201568cbf4b7bc5382a4&pid=1-s2.0-S0975947623001328-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ayurvedic evaluation & treatment of multiple myeloma: A case report","authors":"Abhijeet Sarjerao Shirkande ,&nbsp;Ankita Abhijeet Shirkande ,&nbsp;Jayashree Changade ,&nbsp;Vaishanvi Tondon","doi":"10.1016/j.jaim.2023.100865","DOIUrl":"10.1016/j.jaim.2023.100865","url":null,"abstract":"<div><p>This case report discusses the management of multiple myeloma in a 59-year-old male patient through an integrative approach of Ayurvedic and conventional medical care. The patient presented with symptoms of pain in ribs, fatigue, nausea, weight loss, and mental stress. After undergoing chemotherapy and steroid therapy, the patient opted for Ayurvedic treatment instead of a recommended bone marrow transplant. Ayurvedic examination revealed imbalances in <em>Vata</em> and <em>Pitta</em> doshas, affecting various body tissues and mental state. The Ayurvedic regimen led to the recovery of the patient without adverse effects. This case highlights the role of Ayurvedic medication in managing multiple myeloma, warranting further research and clinical trials for broader validation.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947623001821/pdfft?md5=a91cbb49978611c38b4a69c0c21e4b1c&pid=1-s2.0-S0975947623001821-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of leaf aqueous extracts from Gardenia ternifolia Schumach. on alcoholic liver disease in Wistar rats","authors":"Desmond Nguetsa Sakou DIPES ,&nbsp;Borris Rosnay Galani Tietcheu PhD","doi":"10.1016/j.jaim.2023.100851","DOIUrl":"https://doi.org/10.1016/j.jaim.2023.100851","url":null,"abstract":"<div><h3>Background</h3><p><em>Gardenia ternifolia</em> (GT) is a plant of the Rubiaceae family, with a wide range of ethnopharmacological properties. However, its hepatoprotective effects were poorly investigated. This work aimed at assessing the hepatoprotective activity of GT leaf aqueous extracts against chronic ethanol-induced damage <em>in vivo</em>.</p></div><div><h3>Materials and methods</h3><p>Male Wistar albino rats were given orally 10 % ethanol (10 mL/kg) and different doses of GT extracts (50, 100, and 200 mg/kg) or distilled water (negative control) simultaneously and daily for 28 days. Normal controls were fed with a normal diet while positive controls received, in addition to ethanol, silymarin (50 mg/kg). After treatment, animals were sacrificed, blood and liver samples were collected, various biochemical parameters were quantified and the histological sections were performed. Moreover, a qualitative phytochemical analysis of this extract was carried out.</p></div><div><h3>Results</h3><p>GT administration significantly reduced alanine aminotransferase (10.35 ± 2.13 U/L and 9.07 ± 2.13 U/L vs 24.43 ± 4.28 UI/L) and aspartate aminotransferase (14.25 ± 3.02 and 18.32 ± 2.13 UI/L vs 34.61 ± 3.23 UI/L) activities at doses of 50 and 100 mg/kg respectively in comparison with the negative control. Likewise, serum triglyceride and total cholesterol levels were significantly reduced by GT extract, especially at the dose of 200 mg/kg compared to the ethanol-treated group. Histological examination showed that the extract protected the liver by reducing hepatic cytolysis, and leukocyte infiltration. Different secondary metabolites including condensed tannins, phenolic acids, and saponins were found in the GT extract but none of these compounds corresponded to epicatechin, coumarin and naringenin.</p></div><div><h3>Conclusion</h3><p>These results show that GT extract may be a potential therapeutic agent against alcoholic liver disease.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947623001687/pdfft?md5=7324d44cf94588bb6f2d50e1d774ecde&pid=1-s2.0-S0975947623001687-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139435970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized, placebo controlled, double blinded, parallel group clinical study to evaluate the efficacy and safety of AEV01 along with standard care for elderly patients with mild COVID-19","authors":"Aravinda Kumar Balan ,&nbsp;Ramesh Kannan ,&nbsp;Vanitha Muralikumar ,&nbsp;Vamseedhar Annam ,&nbsp;Sakthi Balan Murugesan ,&nbsp;MM Sekhar ,&nbsp;Renu Medasani","doi":"10.1016/j.jaim.2023.100860","DOIUrl":"10.1016/j.jaim.2023.100860","url":null,"abstract":"<div><h3>Background</h3><p>While several drugs are in the pipeline for treatment of various grades of COVID-19 disease, none of them have shown promise until now. Medicinal plants are crucial in developing and developed countries for their primary and basic health needs owing to better tolerability, superior compatibility with human body and having lesser side effects. <strong>Objective:</strong> To test adjuvant effect of AEV01, a patented herbal extract of kutki (<em>Picrorhiza kurroa</em>), in mild COVID19 in elderly patients at risk of complications and aging immunity.</p></div><div><h3>Methods</h3><p>A prospective, phase 3, randomized, multicentric, placebo controlled double blinded parallel group interventional trial was conducted in elderly patients aged above 50 years diagnosed as COVID-19 with mild symptoms. 70 patients were randomized into two groups to receive AEV01 capsule (100 mg) and placebo respectively thrice daily for 30 days along with standard care of treatment as per national (WHO/ICMR) guidelines in both the groups. Clinical improvement timelines and corresponding scores using 8-point ordinal scale and NEWS were assessed for efficacy and safety of AEV01 in COVID-19 patients.</p></div><div><h3>Results</h3><p>AEV01 group showed a significant improvement (p = 0.0001) in the normalization of the SpO₂ rate and relief from cough. There was also significant difference in time to recovery, with patients in the AEV01 drug treated group recovering in 4.5 days as compared to Placebo in 9.1 days. ESR, LDH, serum ferritin, Neutrophil-Lymphocyte ratio (NLR), TNF- alpha, IL-6 and CD4 cell counts, which are considered as prognostic markers in COVID-19 infected patients, showed a significant improvement in patients treated with AEV01. The AEV01 drug treated group showed significant clinical improvement in the 8-point ordinal scale severity rating and National Early Warning Score (NEW) Score from day 3 onwards which continued up to end of study.</p></div><div><h3>Conclusion</h3><p>AEV01 has shown a significant improvement in clinical and laboratory parameters. There was also reduction in the progression of the COVID-19 disease in unvaccinated elderly patients from mild to moderate when treated at an earlier stage.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947623001778/pdfft?md5=0110d4d7e17c8defdae0541fbd0bb29d&pid=1-s2.0-S0975947623001778-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conference report: Dhara - Vision Ayurveda 2047","authors":"Sanchita Sangle,&nbsp;Prajakta Pakhale,&nbsp;Madhura Joshi,&nbsp;Akash Saggam","doi":"10.1016/j.jaim.2023.100848","DOIUrl":"https://doi.org/10.1016/j.jaim.2023.100848","url":null,"abstract":"<div><p>The Dhara-Ayurveda 2047 conference was organized at the University of Trans-Disciplinary Health Sciences and Technology (TDU), Bengaluru on 23rd and September 24, 2022. This was a pioneering initiative of Ministry of Culture and Ministry of Ayush to raise public awareness about the contemporary relevance of India's medical heritage. The theme of the conference was to offer innovative approaches to strengthen and globalize Ayurveda by the year 2047 to commemorate 100th year of independence of India.</p><p>More than 2000 delegates from academia and industries attended this event. This conference featured a range of components including insightful vision talks, educational exhibition, interactive practical sessions, innovation-focused competition, cultural programs, and health assessment program. Distinguished speakers shared their forward-looking perspectives on the future of Ayurveda in the year 2047 with respect to personalized nutrition, Ayurvedic healthcare, interdisciplinary medicine, AYUSH integration, Ayurvedic industry, and other related topics. The conference provided a platform for students to learn innovative approaches in Ayurveda and also awarded deserving winners for their ideas.</p><p>Thus, Dhara-Ayurveda 2047 conference served as a valuable platform for sharing knowledge and exploring the future of Ayurveda in India across different disciplines related to Ayurveda like biomedical sciences and engineering, information technology, pharmaceutical sciences and folk healers to visualize Ayurveda in the year 2047.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947623001651/pdfft?md5=87f29121bb8405cca6ae9516c4382072&pid=1-s2.0-S0975947623001651-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139494112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Millets as a dietary supplement for managing chemotherapy induced side effects","authors":"Swagata Dilip Tavhare","doi":"10.1016/j.jaim.2024.100901","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100901","url":null,"abstract":"<div><p>Millets, the nutria-cereals, are one of the oldest utilized grain. Millets are reported to possess nutraceuticals health benefits which include improvement in functioning of digestive system, reduction in cholesterol, prevention of heart disease, protection against diabetes, lowering risks of cancer etc. With the widespread commemoration of the International Year of Millets in 2023, the Indian government is moving towards the global recognition of millets in light of its medicinal value in correction of lifestyles diseases. One of the common non-communicable diseases is cancer. Chemotherapy is used as adjuvant, neo-adjuvant or as a combination, in metastatic settings. It is linked to outcomes, but it also has unfavorable side effects that lower a patient's quality of life. The reported chemotherapy side effects includes loss of appetite, nausea, vomiting, weakness, hair loss, osteoporosis, immunological suppression and gastric disturbances such as dry mouth, altered taste, ulcers, constipation etc. The effectiveness of tumor therapy and the extension of treatment are both influenced by side effect management. One way to help cancer patients with their polypharmacy load is through dietary management. Rich in phytochemicals, fiber, vitamins, and minerals, millets can be suggested as a dietary therapeutic intervention in addition to chemotherapy. Being widely accessible, cost effective, nutrient-dense, high in fiber, gluten-free, anti-inflammatory, antioxidant, lipid lowering, gastro-protective, immunomodulator in action, millets can serve as a good diet choice to minimize side effects of chemotherapy.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000160/pdfft?md5=b89541f1c9625aa2585cba8c52ccdfa7&pid=1-s2.0-S0975947624000160-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139986978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homeopathic preparation of Allium sativum abrogates OxLDL mediated atherogenic events in macrophages: An in vitro and in silico approach","authors":"Thangarajeswari Mohan ,&nbsp;Abinayaa Rajkumar ,&nbsp;Gokulprasanth Panchalingam ,&nbsp;Debadatta Nayak ,&nbsp;Malathi Raghunathan ,&nbsp;Kalaiselvi Periandavan","doi":"10.1016/j.jaim.2023.100850","DOIUrl":"https://doi.org/10.1016/j.jaim.2023.100850","url":null,"abstract":"<div><h3>Background</h3><p>Oxidized LDL (OxLDL), the key player in atherogenesis modulates endothelial dysfunction, initiates monocyte recruitment, accentuates foam cell formation, and flares up inflammatory and apoptotic events. Even though homeopathic preparation of <em>Allium sativum</em> has been proved to be an anti-inflammatory, anti-apoptotic and anti-atherogenic agent, its mechanism of action on abrogating OxLDL mediated foam cell formation is yet to be explored.</p></div><div><h3>Objective</h3><p>This study was designed to bring out the role of homeopathic preparation of <em>Allium sativum</em> in curbing OxLDL mediated cellular inflammation in IC-21 cells exposed with OxLDL.</p></div><div><h3>Materials and methods</h3><p>OxLDL was used to induce oxidative damage in the IC-21 macrophage cells. Assessment of inflammatory cytokines, localization of NFκB, detection of apoptosis and the <em>in silico</em> analysis were performed in this study.</p></div><div><h3>Results</h3><p>The current study portrays the efficacy of homeopathy medicine as an anti-inflammatory agent, in reducing the levels of inflammatory cytokines and its mRNA expression, suppressing the activity of NFκB and preventing apoptosis in OxLDL treated IC-21 cells.</p></div><div><h3>Conclusion</h3><p>To conclude, homeopathic preparation of <em>Allium sativum</em> 6C and 30C potencies are capable of controlling the transcriptional activity of NFκB and apoptosis in IC-21 cells exposed to OxLDL. These results implicate that <em>Allium sativum</em> homeopathic drug can be used as anti-inflammatory agent in reducing atherogenic events as it is capable of preventing OxLDL-mediated injury to macrophages.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947623001675/pdfft?md5=59be8dce99ea494ed41d31b799366875&pid=1-s2.0-S0975947623001675-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139435969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}