Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Virtual screening and network pharmacology-based synergistic coagulation mechanism identification of multiple components contained in compound Kushen Injection against hepatocellular carcinoma","authors":"Kejun Zhou ,&nbsp;Mengyi Xie ,&nbsp;Yu Liu ,&nbsp;Lei Zheng ,&nbsp;Juan Pu ,&nbsp;Cheng Wang","doi":"10.1016/j.jaim.2024.101055","DOIUrl":"10.1016/j.jaim.2024.101055","url":null,"abstract":"<div><h3>Background</h3><div>Hepatocellular carcinoma (HCC) is a primary liver malignancy commonly encountered in the setting of chronic liver disease and cirrhosis. Compound Kushen Injection (CKI) has been widely used in HCC, however, the underlying mechanisms are scarce.</div></div><div><h3>Objective</h3><div>To explore the molecular mechanisms of CKI for HCC.To explore the molecular mechanisms of CKI for HCC.</div></div><div><h3>Materials and Methods</h3><div>The chemical ingredients of CKI were reviewed from published articles and the potential targets were got from Herbal Ingredients’ Targets Platform. Coagulation-related targets were from Kyoto Encyclopedia of Genes and Genomes and HCC-related targets were from Therapeutic Target Database, Gene Expression Omnibus, and The Cancer Genome Atlas. Then the CKI-Herb-Target and CKI-Herb-Target-HCC networks were built. The shared targets between CKI and HCC were used for functional enrichment through Metascape and the shared coagulation-related target was used for molecular docking and survival analysis.</div></div><div><h3>Results</h3><div>A total of 23 chemical ingredients and 41 potential targets shared between CKI and HCC were obtained. The results of functional enrichment indicated that several canonical pathways of CKI mostly participated in the treatment of HCC. Furthermore, a chemical ingredient of CKI formed a stable hydrogen bond link with the ASN-189 on PLG, with a best binding energy of −4.7 kcal/mol. Finally, PLG was confirmed as the shared coagulation-related target and interrelated with the prognosis of HCC.</div></div><div><h3>Conclusion</h3><div>CKI probably improves HCC prognosis through PLG. Our research undoubtedly deepened the understanding of the molecular mechanism of CKI anti-HCC.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101055"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Withania somnifera based supplement for immunomodulatory and antiviral properties against viral infection","authors":"Dileep Kumar Verma ,&nbsp;Abdul Hasan ,&nbsp;Manickavasagam Rengaraju ,&nbsp;Shree Devi ,&nbsp;Geetika Sharma ,&nbsp;Vimal Narayanan ,&nbsp;Sathiyarajeswaran Parameswaran ,&nbsp;Thirumal Kumar D ,&nbsp;Kanakavalli Kadarkarai ,&nbsp;Sujatha Sunil","doi":"10.1016/j.jaim.2024.100955","DOIUrl":"10.1016/j.jaim.2024.100955","url":null,"abstract":"<div><h3>Background</h3><div>Viral mediated diseases are continuously posing potent threat to human health. Nutraceuticals are being employed as novel therapeutics during viral outbreaks. MAM granules consist of <em>Curcuma longa</em>, <em>Withania somnifera</em>, and <em>Piper nigrum</em>, is one such patented Siddha nutraceutical supplement that has been proposed to be a therapeutic agent against viral diseases.</div></div><div><h3>Objective</h3><div>We characterised MAM for their phytochemical and physicochemical properties and evaluated its cytotoxicity via <em>in vivo</em> acute toxicity studies using Wistar rats and by cell-based MTT assays.</div></div><div><h3>Materials and Methods</h3><div>The antiviral properties of the aqueous extract of MAM were investigated against SARS-CoV-2 and chikungunya virus (CHIKV). Further, using ABTS radical scavenging, SOD enzymatic assays and measurement of intracellular ROS, we investigated the antioxidant potential of MAM extract and its ingredients in RAW264.7 cells. Additionally, production of inflammatory mediators was evaluated via NO release, PGE2 production and release of pro-inflammatory cytokines (IL-1<em>β</em> and TNF<em>α</em>).</div></div><div><h3>Results</h3><div>The MAM granules and aqueous extracts demonstrated no significant toxicity and demonstrated potent antiviral activity during co-incubation assay with SARS-CoV-2 and CHIKV. Moreover, we observed potent antioxidant and anti-inflammatory activity of MAM extract in a dose dependent manner. Further investigations on the individual ingredients with respect to their antioxidant and anti-inflammatory activities showed that all ingredients contributed synergistically and <em>Withania somnifera</em> showed most potent anti-oxidant activity.</div></div><div><h3>Conclusion</h3><div>The overall in vitro, and <em>in vivo</em> analysis demonstrated that MAM granules were non-toxic and possessed potent antiviral activity. Additionally, observed significant anti-oxidant and anti-inflammatory properties of MAM suggested the modulation of innate immune response in the host validating its use as an effective nutraceutical during viral outbreaks.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100955"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory single-arm open-label clinical study to evaluate the combined effect of Vamana and Sarasvata Churna in reducing excessive daytime sleepiness","authors":"Arathy Menon ,&nbsp;Devipriya Soman ,&nbsp;James Chacko ,&nbsp;P.V. Anandaraman ,&nbsp;Mahesh C. Kundagol ,&nbsp;K. Sreejith","doi":"10.1016/j.jaim.2024.100960","DOIUrl":"10.1016/j.jaim.2024.100960","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Excessive Daytime Sleepiness (EDS) is inferred as persistent sleepiness and often a general lack of energy during the day even after apparently adequate or even prolonged nighttime sleep. The subjects may not be identifying excessive daytime sleepiness but may present as feeling tired, lack of energy etc. They may seem apparently healthy and without any other systemic illness. The prevalence was found to be as high as 18 % in 2012 in United Kingdom. Also, it is a risk factor for diseases like Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases. Conventional management (Modafinil, Sodium Oxybate and Stimulants) addresses only the subjective condition in EDS and is associated with adverse effects compromising the quality of life. In the current health scenario there is a need for alternative interventions to manage this disease. On analyzing this condition through &lt;em&gt;Ayurveda&lt;/em&gt;, we could understand it as &lt;em&gt;Nidradhikya&lt;/em&gt; (Excessive daytime sleepiness) which is caused due to vitiated &lt;em&gt;Kapha Dosha&lt;/em&gt; along with &lt;em&gt;Vriddha Tamoguna&lt;/em&gt; (increased &lt;em&gt;Tamoguna&lt;/em&gt;) that can be managed by &lt;em&gt;Shodhana&lt;/em&gt; (biopurification) followed &lt;em&gt;Shamana&lt;/em&gt; (pacification) therapies.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;This study was aimed to assess the combined effect of &lt;em&gt;Vamana&lt;/em&gt; (therapeutic vomiting) and &lt;em&gt;Sarasvata Churna&lt;/em&gt; in reducing Excessive Daytime Sleepiness.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;p&gt;This was a single-arm exploratory open-label clinical trial. 10 subjects having EDS diagnosed using Modified Epworth Sleepiness Scale (MESS) with a score of 10–24 with proper exclusion were recruited from OPD and IPD, Department of &lt;em&gt;Kāyacikitsa&lt;/em&gt;, Amrita School of Ayurveda. All the participants were clinically examined, sought for medical history and further checked biochemically to exclude any other systemic illness that may lead to this condition. Only healthy subjects with quality night sleep (assessed by PSQI) and without any other systemic illness were selected. The treatment protocol adopted was &lt;em&gt;Vamana Karma&lt;/em&gt; followed by 30 days of &lt;em&gt;Sarasvata Churna&lt;/em&gt; as &lt;em&gt;Shamana Aushadha&lt;/em&gt; (medicine for pacification). Assessment was done using MESS on 0&lt;sup&gt;th&lt;/sup&gt; day and after 30 days of &lt;em&gt;Shamana Aushadha Sevana.&lt;/em&gt; After completion of treatment, the results were statistically analysed using Wilcoxon Signed Rank Test and final conclusion was drawn.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;On analysis of the symptoms using Modified Epworth Sleepiness Scale, the mean total score reduced from 14.8 to 2.8 with 81.08 % relief in these 10 subjects and a significant p value &lt; 0.05 after &lt;em&gt;Vamana&lt;/em&gt; followed by 30 days of &lt;em&gt;Shamana Aushadha Sevana&lt;/em&gt;.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;p&gt;&lt;em&gt;Vamana&lt;/em&gt; helps in &lt;em&gt;Kapha Nirharana&lt;/em&gt; (expelling) which removes the &lt;em&gt;Avarana&lt;/em&gt; (occlusion) of &lt;em&gt;Manas&lt;/em&gt; seen in &lt;em&gt;Nidradhikya&lt;/em&gt;. This results ","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100960"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000755/pdfft?md5=614cdfc87ae8f05c98f54c92c8646586&pid=1-s2.0-S0975947624000755-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A consensus guideline on preferred items for reporting case series in homeopathy: The PITCH statement","authors":"Abhijit Dutta","doi":"10.1016/j.jaim.2024.101023","DOIUrl":"10.1016/j.jaim.2024.101023","url":null,"abstract":"<div><h3>Background</h3><div>Case series is a valuable tool for sharing clinical experiences and generating research questions in the field of medicine. However, there is a lack of standardized reporting guideline for case series in homeopathy, which limits their utility and comparability. The aim of this study is to develop a reporting guideline for case series in homeopathy using a Delphi consensus process.</div></div><div><h3>Method</h3><div>A group of 21 experts, with experience in reviewing, publishing, or editing case reports or series in homeopathy, were participated in the study. A modified Delphi consensus process was conducted with three rounds of electronic surveys to gather feedback and opinions on the items to be included in the reporting guideline. The GRADE group's nine-point Likert scale was used to rate each item's importance and criticality.</div></div><div><h3>Result</h3><div>The Delphi process resulted in a consensus-based reporting guideline for case series in homeopathy, which includes recommendations for reporting case series in eleven sections, including 'Title,' 'Abstract,' 'Keywords,' 'Introduction,' 'Methods,' 'Results,' 'Discussion,' 'Conclusion,' 'Patient Perspectives,' 'References,' and 'Additional Information.' PITCH comprises a total of 59 items that achieved consensus agreement. Of these, 13 are optional items and 14 items are exclusively applicable for prospective type of case series.</div></div><div><h3>Conclusion</h3><div>The PITCH reporting guideline provides a structured and standardized approach for reporting case series in homeopathy. The authors, journal editors, reviewers, and educators are encouraged to adopt and implement the guideline to enhance the quality of case series in homeopathic publications.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101023"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse pharmacology based clinical protocols for noninvasive integrative management of low grade cervical precancer lesions: Rationale and outcomes","authors":"J.V. Joshi ,&nbsp;A.A. Raut ,&nbsp;P.H. Paradkar ,&nbsp;S.S. Jagtap","doi":"10.1016/j.jaim.2024.100966","DOIUrl":"10.1016/j.jaim.2024.100966","url":null,"abstract":"<div><p>Prevention is the most efficient and cost-effective method to combat cervical cancer for which High Risk Human Papilloma Virus (HR-HPV) infection is identified as the major causative factor. HPV vaccination is for primary prevention whereas surgical ablation of precancer is for secondary prevention after HPV infection has occurred. Screening of women for early detection of Squamous Intraepithelial Lesions (SILs) with Papanicolou smear (Pap smear) is a desirable pre-requisite. Surgical ablation which invites invasive procedures is not accessible nor affordable to the larger section of the population. We propose here a non-invasive integrative management approach for the early phase of cervical pre-cancer.</p><p>In tune with the reverse pharmacology approach, ‘experience-exploration- experimentation’, we have conducted five clinical studies related to Turmeric extracts for chemo-preventive activity and non-surgical feasibility. We were able to achieve arrest or regression in Low-grade SILs in all 41 women participating in these studies.</p><p>The unique features of this integrative management approach were i) Avoidance of surgery-associated trauma, cost and complications ii) Standard of care for associated genital infections iii) Feasibility when surgery was not accessible iv) Scope for repeating the noninvasive treatment.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100966"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000810/pdfft?md5=c852cad33b0666ba99e0056247e76456&pid=1-s2.0-S0975947624000810-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142135838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of congenitally fused cervical vertebrae with Ayurveda intervention - A case report","authors":"Ranjita Ekka ,&nbsp;Shakti Bhushan ,&nbsp;Ekta Ekta ,&nbsp;Parvathy G. Nair ,&nbsp;Amit Kumar Dixit ,&nbsp;P.V.V. Prasad","doi":"10.1016/j.jaim.2024.100964","DOIUrl":"10.1016/j.jaim.2024.100964","url":null,"abstract":"<div><p>A 42-year-old male patient presented with complaints of vertigo, neck pain, swallowing difficulties, and difficulty in maintaining an upright posture. The patient took allopathic consultation for the complaints and was advised to undergo MDCT scan of brain, hematological and audiological evaluations. No abnormalities were detected in the investigations and he was given some medications for symptomatic management. As no relief was noted, the patient took an Ayurveda consultation. After clinical evaluation, the patient was advised to perform an X-ray of the cervical spine and was diagnosed with congenital block vertebrae at C3 – C4 vertebral bodies and posterior appendages with hypoplastic intervening disc space. He was advised to take Ekangveerarasa 250 mg BD before food with honey, Trayodashang guggulu 1 gm BD after food, Vishatinduka vati 250 mg BD after food, Aswagandha churna 3 gm BD after food with milk.The patient was also advised to do light massage and mild hot fomentation in the neck region twice a day with Mahavishagarbha oil. Remarkable relief was observed with all signs and symptoms including a reduction of score in the Neck Disability Index (NDI) within a very short duration of treatment. Considerable improvements were noted in the quality of life of the patient as confirmed by the WHO QOL BREF score. This case report shows that Ayurveda can offer safer and more effective symptomatic treatment for conditions like congenitally fused vertebrae.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100964"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000792/pdfft?md5=c0ad21ce9ab5d86ce9ddb5e176cdebce&pid=1-s2.0-S0975947624000792-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Product development and characterization of a lipid-based Ayurvedic polyherbal formulation: Kalyanaka Ghrita","authors":"Yashika Singh ,&nbsp;Amzad Ali Ansari ,&nbsp;Rajendra Prasad Sharma ,&nbsp;Saroj Moreshwar Parhate ,&nbsp;Thakur Rakesh Singh","doi":"10.1016/j.jaim.2024.101011","DOIUrl":"10.1016/j.jaim.2024.101011","url":null,"abstract":"<div><h3>Background</h3><div><em>Kalyanaka Ghrita</em> (KG) is polyherbal oleaginous medicament consisting of extracts from twenty-eight different plants, indicated for management of psychosomatic disorders like <em>Unmada</em> (Schizophrenia), <em>Apasmara</em> (Epilepsy) and numerous other ailments.</div></div><div><h3>Objective</h3><div>To develop and validate standard manufacturing procedure of KG by following <em>Ayurvedic</em> principles in three batches to ensure process uniformity and standards.</div></div><div><h3>Materials and methods</h3><div>Three batches of KG were prepared by adopting principles of <em>Ashtanga Hrudya</em> and Ayurvedic Formulary of India to ensure consistency in manufacturing process. Observations during process such as temperature, duration were recorded. KG was subjected to chief desired characteristics, organoleptic (color, odour, taste, texture, touch), physicochemical (acid value, peroxide value, iodine value, saponification value, loss on drying, refractive index, specific gravity, mineral oil, rancidity test, viscosity) as per pharmacopeial standard. Chromatographic screening and fingerprinting of KG were conducted through GCMS whereas quantification of curcumin and chebulagic acid biomarkers were assessed through HPLC.</div></div><div><h3>Results</h3><div>Average yield of KG was 83.41%, with average intermittent heating duration of 20.35 h subsequently divided into three days. Temperature throughout preparation ranged from 66 °C to 101 °C. KG was pale olive in colour, exhibiting pleasant taste, characteristic smell, and soft texture. Organoleptic and physicochemical characters were comparable for three batches of KG while safety parameters were found within permissible limits.</div></div><div><h3>Conclusion</h3><div>Pharmaceutical standardization of <em>Kalyanaka Ghrita</em> is necessary for establishing biological and chemical profile of formulations. Present study recommends use of coarse powdered ingredients for optimal yield during pharmaceutical process, and heating up to <em>Madhyama Paka</em> stage calibrated over three days with average temperature of 85 °C. The data obtained from this study may contribute to future research and development activities, serving as a basis for manufacturing standards of KG.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101011"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jasminum grandiflorum oral gel as an add-on to standard of care in radiation induced grade 2 oral mucositis - an open label pilot clinical trial","authors":"A.R. Anuja ,&nbsp;R. Anoop ,&nbsp;Arun Mohanan ,&nbsp;N.V. Ramesh","doi":"10.1016/j.jaim.2024.100925","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100925","url":null,"abstract":"<div><h3>Background</h3><p>Radiation-induced oral mucositis is one of the most critical dose-limiting toxicities associated with radiation therapy for oral cancer which can result in treatment interruption and compromise the quality of the life of cancer patients. <em>Jati (Jasminum grandiflorum)</em> is used in Ayurveda to treat oral conditions like stomatitis and mouth ulcers.</p></div><div><h3>Objective</h3><p>To test the feasibility of <em>Jati</em> oral gel as an add on therapy in grade 2 radiation-induced oral mucositis.</p></div><div><h3>Materials and methods</h3><p>A prospective, open-label, non-randomised pilot trial was conducted on 20 patients with grade 2 radiation-induced oral mucositis at a tertiary cancer hospital. The control group received sodium bicarbonate mouthwash 4–5 times daily as the standard of care, while the intervention arm also received <em>Jati</em> oral gel twice daily. We used the ImageJ software for objective assessment and the Visual Analogue Scale for subjective pain assessment. The study was continued for 15 days or until the mucositis progressed to grade 3 or resolved to grade 1.</p></div><div><h3>Result</h3><p>There was a significant reduction in the mean pain score and mean area of mucositis in the intervention group compared to the control group.</p></div><div><h3>Conclusion</h3><p><em>Jati</em> oral gel is a suitable medicament as an add-on therapy in managing grade 2 radiation-induced oral mucositis.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 4","pages":"Article 100925"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000408/pdfft?md5=9b15ea528510a29e2dc9fde7b9e9170f&pid=1-s2.0-S0975947624000408-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigonelline, a Fenugreek Bioactive protects Heart tissue against alcohol intoxication: An in-vivo study focusing on antioxidant perspective","authors":"Meesala Guru Sekhar ,&nbsp;Kondeti Ramudu Shanmugam ,&nbsp;Inavolu Srinivasa Chakrapani","doi":"10.1016/j.jaim.2024.100963","DOIUrl":"10.1016/j.jaim.2024.100963","url":null,"abstract":"<div><h3>Background</h3><p><em>Trigonella foenum-graecum</em>, commonly known as fenugreek and it is used as a spice. It has antioxidant, anti-diabetic, antilipedemic and other pharmocological properties.</p></div><div><h3>Objectives</h3><p>The aim of the study was to detect the cardio protective activity of Trigonelline (TG) a bioactive compound of <em>Trigonella foenum-graecum</em> (TF) in alcohol intoxicated rats.</p></div><div><h3>Material and methods</h3><p>The young wistar strain albino rats are divided in to 5 groups and treatment was given as per the experimental protocol. Antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR), glutathione (GSH), malondialdehyde (MDA) levels are estimated in cardiac tissue of all experimental groups. Cardiac markers creatine kinase-MB (CK-MB), troponin-T (TT), troponin-I (TI), myoglobin (MG) and serum markers alanine transaminase (AAT), aspartate transaminase (AST) and alkaline phosphatase (ALP) are estimated. Free radical scavenging activities like 2,2-diphenylpicrylhydrazyl (DPPH), hydrogen peroxide (H₂O₂) and hydroxyl radical are estimated in ethanolic extract of <em>Trigonella foenum-graecum</em>.</p></div><div><h3>Results</h3><p>SOD, CAT, GPx, GR, GSH activities are depleted and MDA, CK-MB, TT, TI, MG and AAT, AST, ALP activities are elevated in alcohol intoxicated rats. Trigonelline supplementation to alcoholic rats for 30 days elevated antioxidant enzymes, depleted MDA, cardiac markers and serum markers in alcohol intoxicated rats. Free radical scavenging assay also reported that <em>Trigonella foenum-graecum</em> possess free radical scavenging activity. Furthermore, our histopathological evidence also proved that TG protected the cardiac tissue from alcohol induced toxicity in all the experimental rats.</p></div><div><h3>Conclusion</h3><p>Our study concluded that TG may be useful to the alcoholic and myocardial infarction subjects.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 4","pages":"Article 100963"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000780/pdfft?md5=d525e4e9484078802ad2b0d1241aa656&pid=1-s2.0-S0975947624000780-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of Ficus benghalensis in thromboembolic disorders","authors":"Anil Kumar Sahu ,&nbsp;Drishya Dinesh ,&nbsp;Vipin Kumar Verma,&nbsp;Vaishali Prajapati,&nbsp;Jagriti Bhatia,&nbsp;Dharamvir Singh Arya","doi":"10.1016/j.jaim.2024.100929","DOIUrl":"10.1016/j.jaim.2024.100929","url":null,"abstract":"<div><h3>Objective</h3><p><em>Ficus benghalensis</em> L. (<em>FB</em>) is a popular plant described in the Indian system of medicine. Traditionally, it is indicated in the treatment of diseases like diabetes mellitus, dysentery, leucorrhoea, menorrhagia, skin disease, rheumatism, inflammatory diseases, blood disorders. This paper accentuates the anti-thrombotic action of <em>FB</em> based on the properties like anti-coagulant, platelet-antiaggregatory, anti-atherogenic hypotensive, hypolipidemic, anti-oxidant, anti-inflammatory and immunomodulatory.</p></div><div><h3>Methods</h3><p>All the available data pertaining to <em>FB</em> has been searched in the scientific databases, including PubMed, Google Scholar, ScienceDirect and Scopus.</p></div><div><h3>Results</h3><p><em>FB</em> is a rich lode of organic compounds such as phenols, flavonoids, alkaloids, tannins, terpenoids and steroids. The various studies show that these phytochemical constituents exhibit wide range of anti-thrombotic actions such as anticoagulant, platelet <em>anti</em>-aggregatory, anti-atherogenic, hypolipidemic, hypotensive, anti-inflammatory, and antioxidant.</p></div><div><h3>Conclusion</h3><p>Various studies (<em>in vitro</em> and <em>in vivo</em>) confirm the potential anti-thrombotic benefit of <em>FB</em> due to the presence of chemical structures that have proven to be effective in thromboembolic conditions. These evidences may benefit in new drug development to treat varied thromboembolic conditions which will not only be cost effective but may allay the fear of side effects.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 4","pages":"Article 100929"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000445/pdfft?md5=25d7ebc995ffa03d8fa03ebfcf034457&pid=1-s2.0-S0975947624000445-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}