Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Management of Otitis externa with Ayurvedic formulation Gandhak Rasayana- A case report","authors":"Sandip Patil,&nbsp;Pravin Bhat","doi":"10.1016/j.jaim.2024.100893","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100893","url":null,"abstract":"<div><p>Otitis externa is an inflammatory and infectious disease that affects the external auditory canal. The term otorrhea refers to the outflow of discharge from the ear which is one of the main symptoms of otitis externa along with inflammation. External ear canal pathology or middle ear illness with tympanic membrane perforation is the etiological factor of otorrhea. Otorrhea is an indication of infection. Antimicrobial agents are the conventional treatment of various bacterial and fungal infections, but they have impediments such as resistance development, side effects, patient affordability, etc. The <em>Gandhak Rasayana</em> formulation mentioned in the <em>Ayurvedic</em> text can be a good option for the treatment of various infectious diseases. <em>Karnasrava</em> is a type of ear disease referred to as <em>Vata</em> predominant <em>Tridoshaja</em> disease and it is curable. The term <em>Karnasrava</em> signifies discharge from ear and is self-explanatory. <em>Karnasrava</em> consists of a wide spectrum of diseases and can have a near correlation with otitis externa as per signs and symptoms. <em>Gandhak Rasayana</em> exhibited significant antibacterial, antifungal and anti-inflammatory activity in otitis externa. Evaluating its antibacterial and antifungal activity can provide scientific evidence for the study through the present case report.</p><p>A 31-year-old male patient registered in OPD at Sane Guruji Hospital, Hadapsar, Pune was clinically diagnosed as <em>Karnasrava</em> (Otitis externa) and pus culture positive for Klebsiella species.</p><p>We started the treatment with <em>Gandhak Rasayana</em>-an <em>Ayurvedic</em> formulation of 250mg two tablets in the morning and evening with lukewarm water for 21 days. The outcome of the treatment was observed as a reduction in <em>Karnashula</em> (otalgia), <em>Karnasrava</em> (ear discharge), <em>Karnakandu</em> (itching), ear blockage and inflammatory changes. Post-treatment culture was negative for the organism. The improvement was noted in Brighton grading scale from grade III to grade I.</p><p><em>Gandhak Rasayana</em> showed significant antibacterial activity in the present case. Evaluating its antibacterial, antifungal and anti-inflammatory activity can provide scientific evidence for the study.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000081/pdfft?md5=9449e736599858548816ba2c884890cb&pid=1-s2.0-S0975947624000081-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of yoga on hypothyroidism: A systematic review","authors":"Abhijit Baishya,&nbsp;Kashinath Metri","doi":"10.1016/j.jaim.2024.100891","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100891","url":null,"abstract":"<div><p>Evidence from clinical trials has shown positive effects of yoga on hypothyroidism. To date, there is no review of these studies. This systematic review evaluates the efficacy of yoga as a therapeutic intervention for hypothyroidism.</p><p>PubMed, Medline, PsycINFO, and Science Direct databases were searched to identify relevant literature. The review included clinical studies that evaluated the effects of yoga on hypothyroidism. Studies that were not conducted inenglish, unavailable, non-experimental, or those that were reviews, case studies, case reports, not based on yoga, involved yoga as a intervention, or included a mixed population were excluded.</p><p>Eleven studies (n = 516) met the eligibility criteria. Of these, four studies were RCTs, two non-RCTs and five were pretest-posttest studies. The duration of the yoga intervention varied from 1 to 6 months. Most of these studies adopted a combination of suryanamaskar, asana, pranayama and meditation. On quality assessment, one study had a low risk of bias (1 RCT), six studies had a moderate risk of bias (3 RCTs, one non-RCT and two pretest-posttest studies), and four studies had a high risk of bias (1 non-RCT and three pretest-posttest studies). The outcome measures assessed were TSH, T3, T4, and thyroid medication usage, lipid indices, BMI, heart rate variability, pulmonary measures, blood glucose, anxiety, depression, self-esteem, quality of life and sleep. The majority of the studies reported significant improvements in these outcomes following yoga intervention.</p><p>This systematic review reports evidence for effects of yoga on various outcome measures in hypothyroidism, suggesting its possible role in the management of hypothyroidism. However, there is a need for adequately powered, high-quality RCT studies in the future to draw a definitive conclusion.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000068/pdfft?md5=611d2e89a19fbabf08f74d6fd8da0306&pid=1-s2.0-S0975947624000068-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140163993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting evidence-base for Ayurveda","authors":"Kishor Patwardhan","doi":"10.1016/j.jaim.2019.10.001","DOIUrl":"10.1016/j.jaim.2019.10.001","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947619303912/pdfft?md5=fc33987b62f39b3e25e491c892953277&pid=1-s2.0-S0975947619303912-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42537086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of lead sulfide obtained from Naga Bhasma","authors":"Manoj Kumar Dash ,&nbsp;Namrata Joshi ,&nbsp;Laxmikant Dwivedi ,&nbsp;Vd Sushil Dubey ,&nbsp;Kamal Nayan Dwivedi","doi":"10.1016/j.jaim.2023.100864","DOIUrl":"https://doi.org/10.1016/j.jaim.2023.100864","url":null,"abstract":"<div><h3>Background</h3><p>Lead sulfide nanoparticles were manufactured from lead oxide using a procedure described in the Ayurveda formulary of India, which involved using a quantum of the heat of up to 60 puta, which is officially known as the <em>Shasti puta Naga Bhasma</em>.</p></div><div><h3>Objective</h3><p>The study shows sulfurization of nanoparticles significantly decreased their toxicity due to the lower solubility.</p></div><div><h3>Materials and Methods</h3><p>The present work used the arsenic sulfide media and traditional puta for processing and the characterization of the same has been conducted. Different analytical techniques like X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-Ray (EDX) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and thermo-gravimetry analysis (TGA) were used.The study shows sulfurization of nanoparticles significantly decreased their toxicity due to the lower solubility. Materials and Methods: The present work used the arsenic sulfide media and traditional puta for Naga bhasma processing and the characterization of the same has been conducted. Different analytical techniques like X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-Ray (EDX) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and thermo-gravimetry analysis (TGA) were used.</p></div><div><h3>Results</h3><p>Powder x-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, Thermogravimetric analysis, and differential thermal analysis all showed that the produced nanoparticles are lead sulfide nanoparticles with a particle size of an average of 84.60 and the crystalline average size of 69.06 nm.</p></div><div><h3>Conclusion</h3><p>The rounded, rod, oval, cubic, and circular morphology of the produced lead sulfide nanoparticles can be seen in the SEM image. The stretching and bending functional groups in the sample were alkanes, alkenes, aromatic hydrocarbons, aromatic hydrocarbons, carboxylic acids, alkyl carboxylic acids, alkyl alpha, beta-unsaturated, aldehydes, ketones, carboxylic acid, aliphatic amines, primary amines, secondary amines, alkyl halides, alkyl halides are studied through the FTIR spectrum.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S097594762300181X/pdfft?md5=1b9111afc3c7d85e4e72044f5ecb67d0&pid=1-s2.0-S097594762300181X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrative approach for management of post-traumatic dorsal foot wounds - A case report","authors":"Rahul Sherkhane ,&nbsp;Shruti Singh ,&nbsp;Aadithyaraj K T ,&nbsp;Anil Kumar ,&nbsp;Ashish Sharma ,&nbsp;Shiv Ji Gupta","doi":"10.1016/j.jaim.2024.100905","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100905","url":null,"abstract":"<div><p>Crush injuries to the foot have become increasingly prevalent in contemporary settings, primarily arising from incidents such as the impact of large objects falling onto the foot or involvement in traffic accidents. The complexity of treating these injuries is compounded by the intricate anatomy of the foot. In specific scenarios, the implementation of an integrated management approach could prove advantageous.</p><p>In this report, we depict the case of a 23-year-old male who visited the Shalya OPD with a wound on his left foot caused by trauma. The wound covered the medial portion of the foot, involving the dorsal area, and measured roughly 20 cm by 9 cm and was unable to walk. We successfully managed the case by adopting an integrative approach. The Ayurvedic treatment included <em>Panchavalkala kashaya</em> for wound irrigation, as well as oral administration of <em>Amalaki rasayana, Triphala guggulu</em>, <em>Shatavari churna</em> and <em>Ashwagandha churna</em>. <em>Jatyadi taila</em> was topically applied. For the first seven days, in addition to these ayurvedic medications, we also employed analgesics and antibiotics to treat infection and pain. To accomplish early closure, we employed a split-thickness skin graft after sufficient granulation tissue had appeared.</p><p>The wound was completely healed within three months and the patient was able to walk freely without any support. The combined approach yielded a promising result in this case.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000202/pdfft?md5=e9598fd3f6bb8719840d055f598b91ba&pid=1-s2.0-S0975947624000202-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140345091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical review of the book ‘Arbuda chikitsa- Ayurvedathile veritta vazhikal’ by Dr. P. B. Susheela Saji","authors":"C.K. Saniya,&nbsp;Parvathy G. Nair,&nbsp;P.S. Aswani,&nbsp;A.P. Karthika","doi":"10.1016/j.jaim.2024.100894","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100894","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000093/pdfft?md5=0f3f7bf443a7f328629277d74b1a488a&pid=1-s2.0-S0975947624000093-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga Nidra for hypertension: A systematic review and meta-analysis","authors":"Navdeep Ahuja ,&nbsp;Praag Bhardwaj ,&nbsp;Monika Pathania ,&nbsp;Dilasha Sethi ,&nbsp;Arjun Kumar ,&nbsp;Ashwin Parchani ,&nbsp;Akshita Chandel ,&nbsp;Aashish Phadke","doi":"10.1016/j.jaim.2023.100882","DOIUrl":"https://doi.org/10.1016/j.jaim.2023.100882","url":null,"abstract":"<div><h3>Background</h3><p>Hypertension is a prevalent chronic condition that affects a substantial proportion of the world's population. Medications are commonly prescribed for hypertension management, but non-pharmacological interventions like yoga are gaining popularity.</p></div><div><h3>Objective</h3><p>The purpose of this systematic review and meta-analysis is to assess the efficacy of Yoga Nidra (YN) for the management of hypertension.</p></div><div><h3>Methods</h3><p>A systematic review and meta-analysis of clinical trials, i.e., non-randomized and randomized controlled trials (RCTs) was conducted to investigate the effects of YN on hypertension. PubMed, the Cochrane Library, SCOPUS, and EBSCO were searched for relevant studies published up to September 2022. The quality of the included studies was assessed using the Cochrane risk of bias tool. The primary outcome measure was the change in systolic blood pressure (SBP) and diastolic blood pressure (DBP) after YN intervention, analyzed as weighted mean difference (WMD), in comparison to control groups. The random-effects model was used for the meta-analysis. Risk of bias was assessed for RCTs and non-RCTs using Cochrane's RoB-2 and ROBINS-I tools, respectively.</p></div><div><h3>Results</h3><p>Five RCTs and three Non-RCTs involving a total of 482 participants (239 for YN vs 243 for controls) were included in this review. The meta-analysis indicated that YN significantly reduced SBP (WMD = 12.03 mm Hg, 95% CI [7.12, 16.93], <em>Z</em> = 4.80, <em>p</em> &lt; 0.00001) and DBP (WMD = 6.32 mm Hg, 95% CI [3.53, 9.12], <em>Z</em> = 4.43, <em>p</em> &lt; 0.00001) compared to control groups. The overall risk of bias for the three RCTs was high, whereas for the five non-RCTs, one had an overall moderate risk while the other four had an overall serious risk of bias.</p></div><div><h3>Discussion</h3><p>This systematic review and meta-analysis provides evidence supporting the efficacy of YN as a complementary therapy for hypertension management. YN is a safe, cost-effective, and easily accessible intervention that primarily relies on interoception and induces a deep relaxation response in practitioners, aiding them in coping with various components of high blood pressure, such as stress, vascular inflammation, peripheral vascular resistance, etc. Our understanding of the mechanisms of YN is constantly evolving, and there is a need for further research to fully explore and appreciate the significance of this ancient science and its potential efficacy on BP. Considering the results and the multifactorial role of YN, it can act as a safe and reliable adjuvant therapy to complement the pharmacological treatment of hypertension. However, further studies with larger sample sizes, longer follow-up periods, and homogenous populations are warranted.</p></div><div><h3>Conclusion</h3><p>This meta-analysis suggests that YN is effective in reducing SBP and DBP, particularly in individuals with hypertension. The re","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947623001997/pdfft?md5=2b4d326872a62fe3d67d4288d868a146&pid=1-s2.0-S0975947623001997-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140122039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic management of a refractory skin disease clinically diagnosed as Cutaneous Lichen Planus—A case report","authors":"Sushma Naranappa Salethoor ,&nbsp;Shyamasundaran Kulangara ,&nbsp;A.R. Aramya ,&nbsp;Rammanohar Puthiyedath","doi":"10.1016/j.jaim.2023.100884","DOIUrl":"https://doi.org/10.1016/j.jaim.2023.100884","url":null,"abstract":"<div><p>This study reports the successful management of a recurrent, refractory skin disease diagnosed clinically as Cutaneous Lichen Planus (CLP) in a female patient with <em>Ayurvedic</em> treatment. A 42-year-old home maker from <em>Coimbatore</em> presented with blackish-red pigmented skin rashes and white streaks. Though mucous membranes were not affected, she did not respond to homoeopathic and biomedical treatment. The lesions were spread all over the body except for the face, scalp, axillary and genital region. In addition, she complained of dry skin, pain, and itching.</p><p>The condition was treated as <em>Kapha-Pitta</em> dominant <em>Tridoshaja Kushta</em> based on <em>Ayurvedic</em> clinical assessment. The patient recovered after one year of conservative <em>Ayurvedic</em> intervention. After six years, there was a relapse, and the patient was admitted for a full course of <em>Ayurvedic</em> treatment and recovered within six months. <em>Ayurvedic</em> interventions should be considered an option in refractory skin diseases like Cutaneous Lichen Planus.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947623002012/pdfft?md5=7da889aa6a03451675ed65b6ccf803a8&pid=1-s2.0-S0975947623002012-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140181142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid improvement of oculomotor nerve function with ayurvedic treatment in traumatic diplopia - A case report","authors":"K. Shanti ,&nbsp;G. Gopinathan","doi":"10.1016/j.jaim.2024.100889","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100889","url":null,"abstract":"<div><p>Diplopia or double vision has many aetiologies and often presents to the ophthalmologist. The causes of diplopia may be ocular or neurogenic in origin. Any trauma to the eyes in the form of blow-out fractures causes diplopia by damaging the third nerve. The management by the practitioners of contemporary science depends upon the extent of the nerve or muscle injury. Entrapment of muscles requires surgical intervention, whereas others are managed conservatively. The recovery rate is the least for diplopia of traumatic origin.</p><p>A 50-year-old male who sought Ayurvedic treatment for diplopia in the last three months was diagnosed with partial third nerve palsy after a fracture of the left orbit. He underwent Ayurvedic therapy in the form of internal medicines such as <em>Danadanayanadi kashaya, Ksheerabala 101, Vaishwanara churna,</em> and external treatments such as <em>Pratimarsha Nasya, Siro abhyanga, and Tarpana</em>.</p><p>At the end of 2 months of Ayurvedic treatment, the patient completely recovered from diplopia.</p><p>Ayurvedic treatment effectively resolved diplopia in a short time. Patients can benefit from the same if treated promptly in the early stage itself. However, more extensive studies with larger samples will yield more data to prove the potential of Ayurveda in such cases.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000044/pdfft?md5=ca6829186210d635b2932abb7caa17b6&pid=1-s2.0-S0975947624000044-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140163992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of whole system ayurveda management protocol in major depressive disorder- A randomized controlled clinical trial","authors":"Anjali Punia ,&nbsp;Sameeran Chate ,&nbsp;Basavaraj R. Tubaki ,&nbsp;Nagula Himaja","doi":"10.1016/j.jaim.2024.100896","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100896","url":null,"abstract":"<div><h3>Background</h3><p>Major Depressive Disorder (MDD) is one of the common depressive disorder. MDD has high comorbidity and has greater implications on quality of life. Whole system Ayurveda management protocol <em>(WSAP)</em> is explored for it's possible role in management of MDD.</p></div><div><h3>Objective</h3><p>To evaluate the efficacy of Whole system Ayurveda management protocol on Major Depressive Disorder.</p></div><div><h3>Material and Methods</h3><p>Study was a randomized controlled trial. Total 50 patients of MDD meeting the DSM V criteria, age group 20–70 years of either sex participated in the study. They were randomly divided into two groups, control group received Escitalopram 10 mg twice a day and Ayurveda group was on WSAP. Interventions were for 60 days. Assessments were done through various clinical parameters like Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Brief psychiatric rating scale (BPRS), Pittsburgh Sleep Quality Index (PSQI), WHO Quality of Life- BREF (WHOQOL-BREF), Clinical Global Improvement scale (CGI), UKU Side effect scale. Assessments during intervention was on every 15th day.</p></div><div><h3>Results</h3><p>Study showed that Ayurveda group produced significant outcome improvement compared to control group in HDRS (p = 0.01), HARS (p = 0.03), PSQI (p = 0.03), WHOQOL-Bref (p &lt; 0.001) and UKU side effect scale (p = 0.02). Both the group showed improvements in all the parameters except in WHOQOL-Bref where Ayurveda group only showed improvements (p &lt; 0.001). Effect size showed large effect in WHOQOL-Bref. Mild side effects were reported in control group and none in Ayurveda group.</p></div><div><h3>Conclusion</h3><p><em>WSAP was</em> effective in management of MDD and had better side effect profile. Further studies needed.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000111/pdfft?md5=9930dc45b32d0009e6d09c91cfd6bccc&pid=1-s2.0-S0975947624000111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140546322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}