Journal of Ayurveda and Integrative Medicine最新文献

{"title":"A machine learning-based clinical decision support system for effective stratification of gestational diabetes mellitus and management through Ayurveda","authors":"Nisha P. Shetty ,&nbsp;Jayashree Shetty ,&nbsp;Veeraj Hegde ,&nbsp;Sneha Dattatray Dharne ,&nbsp;Mamtha Kv","doi":"10.1016/j.jaim.2024.101051","DOIUrl":"10.1016/j.jaim.2024.101051","url":null,"abstract":"<div><h3>Background</h3><div>Gestational Diabetes Mellitus (GDM) is a metabolic condition that develops in course of pregnancy. The World Health Organization describes it as carbohydrate intolerance that causes hyperglycemia of varying severity and manifests itself or is first noticed during pregnancy. Early prediction is now possible, owing to the application of cutting-edge methods like machine learning.</div></div><div><h3>Objective</h3><div>In the proposed empirical study, different machine-learning algorithms are applied to predict the prospective risk factors influencing the progression of GDM in gestating mothers.</div></div><div><h3>Materials and methods</h3><div>The performance of these algorithms is evaluated through accuracy, precision, f1-score, etc. The lifestyle interventions and medications listed in Ayurveda literature are discussed for effective management of the disease.</div></div><div><h3>Results</h3><div>Most of the proposed classifiers achieved a reasonable accuracy range of 75–82 %. Appropriate lifestyle changes, herbal remedies, decoctions, and churnas have all been shown to be useful in lowering the risk of GDM. Early detection using machine learning models can significantly reduce disease severity by facilitating timely Ayurvedic interventions.</div></div><div><h3>Conclusion</h3><div>The proposed work is more focused on the identification of factors impacting GDM in expectant women. A balanced diet with physical exercise, proper medication, and better lifestyle management (through <em>Garbini Paricharya</em>) can control the perils of GDM if diagnosed prematurely.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 101051"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating anticancer potentials of potentized preparations in an in-vivo xenograft model","authors":"Rajesh Shah ,&nbsp;Gitanjali Talele ,&nbsp;Nirmal Kumar Kasinathan ,&nbsp;Madan Barkume ,&nbsp;Jyoti Kode","doi":"10.1016/j.jaim.2024.101015","DOIUrl":"10.1016/j.jaim.2024.101015","url":null,"abstract":"<div><h3>Background</h3><div>Xenografts in immunodeficient mice play a pivotal role in testing novel anti-cancer treatments. Xenograft models expedite the drug discovery process, offering a cost-effective alternative to conventional animal models and providing essential data for clinical trials. We have followed the approach described by the Developmental Therapeutics Program of the National Cancer Institute (NCI), USA to investigate the therapeutic responses.</div></div><div><h3>Objectives</h3><div>In this research, potentized preparations derived from biomaterial, referred to as nosodes, have exhibited promising effectiveness against cancer in laboratory experiments. This study seeks to further substantiate these findings by employing animal models.</div></div><div><h3>Method</h3><div>Potentized preparations from category nosodes sourced from biomaterials of HIV, Cancer tissue, Hepatitis C and a combination underwent testing within the NCI's preclinical evaluation protocols using Xenograft models (HOP62). All the experimental mice were randomly assigned to one of six groups (n = 6), including vehicle and positive controls. These preparations were administered orally at a dosage of 0.1 ml, five days a week, over a four-week period. The mice were closely monitored at regular intervals for 32 days, with observations regarding changes in body weight, tumor volume, morbidity, and mortality. Relative tumor volume (RTV) was calculated as the tumor volume on the day of measurement divided by the tumor volume on day 1.</div></div><div><h3>Results</h3><div>The groups treated with Hepatitis C 30c and HIV 100c nosodes have not shown effect with respect to Relative Tumor Volume (RTV). Evidence of significant tumor regression was observed for RTV on day 30 in groups treated with HIV nosode 30c (P = 0.002), and Cancer nosode 30c (P = 0.005). Percentage Survival was noted better in HIV nosode 30c treated group from day 25, however, in other groups survival percentage remained constant. Varied animal body weight in all groups was noted. Significant differences in tumor volume with respect to time in all treated groups were observed.</div></div><div><h3>Conclusion</h3><div>Results are suggestive of tumor regression which is encouraging to undertake further clinical trials to explore the anticancer potential of HIV nosode and Cancer nosode.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 101015"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurveda treatment of nevus lipomatosus cutaneous superficialis through Ksharasutra: A case report","authors":"Ranjan Kumar Kasta ,&nbsp;Ajit Kumar Pradhan ,&nbsp;Priyanka Giri ,&nbsp;Prasanta Kumar Sahoo","doi":"10.1016/j.jaim.2024.101031","DOIUrl":"10.1016/j.jaim.2024.101031","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 101031"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Ayurvedic and Allopathic treatment in hereditary breast and ovarian cancer patient with Germline BRCA1 mutation for long term disease free survival: A case report","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Arvind Kulkarni,&nbsp;Shweta Gujar,&nbsp;Vinita Awalkanthe,&nbsp;Nilambari Sardeshmukh,&nbsp;Bhagyashree Sardeshmukh,&nbsp;Dhananjay Deshpande,&nbsp;Anjali Deshpande,&nbsp;Sandeep Chavan","doi":"10.1016/j.jaim.2024.100999","DOIUrl":"10.1016/j.jaim.2024.100999","url":null,"abstract":"<div><div>Ovarian cancer patients with BRCA1 mutation have more susceptibility for secondary breast cancer. In females with BRCA1 mutation, the risk of developing breast carcinoma is 65% and of ovarian cancer is 39%, before 70 years of age.</div><div>This is a case report of a 74 year old, post-menopausal woman diagnosed with metastatic retroperitoneal lymph node, high-grade papillary adenocarcinoma primary ovary stage IIIA in April 2004 at the age of 48 years. She underwent 3 cycles of neo-adjuvant chemotherapy Inj. Methotrexate and Inj. Carboplatin from June to August 2004 followed by optimum cytoreduction in September 2004. Later she completed 3 more cycles of chemotherapy of the same protocol from October to November 2004. Tab Etoposide was given from December 2004 to October 2006. In May 2006, during oral chemotherapy and with unremarkable radiological findings, the patient chose Ayurvedic treatment in view of immune boosting, and improving quality of life. The patient underwent 11 sets of Panchakarma treatment, almost every year, from December 2007 to September 2019. She was disease-free for 13 years leading a good quality of life with adjunct Ayurvedic treatment.</div><div>In October 2019, she was diagnosed with Left breast duct carcinoma with ER, PR hormone positive status. Her genetic mutation analysis report at that time revealed BRCA 1 mutation. She underwent Left Modified Radical Mastectomy in October 2019, followed by prophylactic Right Breast Mastectomy and oral hormonal therapy. Now she is living with better quality of life with adjunct Ayurvedic treatment, including Oral Ayurvedic Medicines possessing <em>Rasayana</em> (immunomodulatory) and hepato-protective activity and 12 sets of <em>Panchakarma Chikitsa</em>.</div><div>In this case of Stage IIIA Ovarian carcinoma and second primary Breast carcinoma with BRCA 1 genetic mutation (HBOC syndrome), a long-term 13 years of disease-free survival, and 20 years of overall survival is achieved with the integration of Ayurvedic treatment and conventional cancer treatment.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 100999"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoleptic, physicochemical, phytochemical and pharmacological evaluation of six medicated ghee used for Ayurvedic management of Epilepsy","authors":"Snehal Moon ,&nbsp;Nishikant Raut ,&nbsp;Harshal Moon ,&nbsp;Anmol Dhawande ,&nbsp;Shailendra Gurav","doi":"10.1016/j.jaim.2024.100995","DOIUrl":"10.1016/j.jaim.2024.100995","url":null,"abstract":"<div><h3>Background</h3><div>Ayurvedic formulations need to be explored and tested with biomedical techniques. Polyherbal medicated <em>ghee</em> (<em>Ghrita</em>) are recommended for the management of epilepsy (<em>Apasmara</em>) and prepared using specialized process (<em>Snehapaka</em>), as per classical textbooks of Ayurveda. So, the present study deals with the systematic examination of the effect of different marketed formulations for treating <em>Apasmara</em> on convulsive impairment in Pentylenetetrazol (PTZ) induced seizures in mice.</div></div><div><h3>Objective</h3><div>To assess organoleptic, physicochemical, phytochemical and pharmacological activity of selected <em>Ghrita</em> formulations used to treat <em>Apasmara.</em></div></div><div><h3>Materials and Method</h3><div>Six marketed <em>Ghrita</em> formulations used for <em>Apasmara,</em> such as Baidyanath <em>Brahmi Ghrita</em> (BBG), Patanjali <em>Brahmi Ghrita</em>, Kotakkal <em>Brahmi Ghrita</em>, <em>Panchagavya Ghrita</em>, <em>Mahapanchagavya Ghrita</em> and <em>Nirgundyadi Ghrita</em> were selected for the study. Selected <em>Ghrita</em> formulations were subjected to physicochemical analysis (following pharmacopeial procedures), phytochemical screening and pharmacological profile for quality and therapeutic efficacy. The screening parameters included pH, viscosity, specific gravity, loss on drying, acid value, saponification value, peroxide value, iodine value, refractive index and rancidity determination, and other phytochemical tests for secondary metabolites.</div></div><div><h3>Results</h3><div>BBG demonstrates superior protection against the onset and duration of convulsions compared to alternative <em>Ghrita</em> formulations. As evidenced by its efficacy in mitigating PTZ-induced convulsions, BBG stands out as the optimal choice for exerting potent anticonvulsant effects.</div></div><div><h3>Conclusion</h3><div><em>In-vivo</em> screening suggests BBG as a potential <em>Ghrita</em> preparation for treatment of epilepsy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 100995"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of wet cupping in a rat model of primary dysmenorrhea","authors":"Sri Lestariningsih ,&nbsp;Didik Gunawan Tamtomo ,&nbsp;Sri Sulistyowati ,&nbsp;Dono Indarto ,&nbsp;Soetrisno Soetrisno ,&nbsp;Hanik Badriyah Hidayati ,&nbsp;Wahyudi Widada","doi":"10.1016/j.jaim.2024.101047","DOIUrl":"10.1016/j.jaim.2024.101047","url":null,"abstract":"<div><h3>Background</h3><div>Primary dysmenorrhea (PD) is characterized by discomfort with no organic etiology (no pelvic disease), recurring pain, or lower abdominal cramps that start between the first 8–72 h of menstruation. Cupping therapy uses a tool to form a vacuum at certain points on the skin.</div></div><div><h3>Objectives</h3><div>We investigated the mechanism of pain relief caused by cupping therapy in primary dysmenorrhea that is played by cupping therapy in PD. This study aimed to investigate the effects of the cupping method on pain symptoms, changes in PGF2α, PGE, and β-endorphin levels, and uterine morphology in PD.</div></div><div><h3>Methods</h3><div>A total of 35 female rats were divided into five groups (n = 7 rats per group): control, PD, dysmenorrhea treated with dry cupping (DC), dysmenorrhea treated with wet cupping (WC), and dysmenorrhea treated with ibuprofen (IB) as a standard drug. Pain was assessed by measuring the degree of writhing pain. Serum PGF2α, PGE, and β-endorphin levels were evaluated using ELISA. Hematoxylin-eosin staining was used to examine uterine morphology, such as thickness, vacuolization, and inflammation.</div></div><div><h3>Results</h3><div>WC had a pain normalization effect comparable to that of ibuprofen. Ibuprofen is superior to both types of cupping in reducing the PGF2α/PGE ratio and the PGF2α to β-endorphins ratio. WC and DC have capabilities comparable to those of ibuprofen in improving uterine vacuolization and inflammation.</div></div><div><h3>Conclusions</h3><div>These results indicate that WC is more effective than DC in suppressing dysmenorrhea symptoms, modulating the hormone level ratio, and repairing uterine pathology. The potential benefits of cupping provide an opportunity for further studies in human subjects.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 101047"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of early-stage diabetic nephropathy with Siddha drug Sirupeelai Kudineer: A case series","authors":"P. Parvathy,&nbsp;G.S. Lekha,&nbsp;S. Aparna,&nbsp;A. Kanagarajan","doi":"10.1016/j.jaim.2024.100993","DOIUrl":"10.1016/j.jaim.2024.100993","url":null,"abstract":"<div><div>Diabetic Nephropathy is one of the major microvascular complications of Diabetes Mellitus, which can be detected in the earlier stage by investigating urinary microalbumin excretion levels and estimating ACR and GFR. Early treatment can delay or prevent the progression of diabetic Nephropathy. Monoherbal Siddha formulation Sirupeelai Kudineer indicated for the complications of Diabetes Mellitus is selected for this Case study. The efficiency of the drug was assessed by measuring the change in renal function throughout the treatment period and the KD QOL assessment. Four patients presented with symptoms of Diabetic Nephropathy were treated with the monoherbal Siddha formulation <em>Sirupeelai Kudineer</em>. This series of four cases showed improvement in CKD QOL and some biochemical parameters. Blood urea was reduced in the four cases during medication. Serum creatinine levels mildly increased in three cases somewhere during the treatment period but decreased in all four cases after treatment. The estimated GFR also improved in three cases after treatment but mildly reduced in one patient. Symptomatic improvement was also observed in all the patients. Marked reduction in blood urea and serum creatinine levels after treatment shows the Nephroprotective action of the drug. The clinical and laboratory parameters observed among these four patients suggest that this drug may be used along with other hypoglycemic drugs to treat Diabetic Nephropathy.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 100993"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning for Ethiopian indigenous medicinal plant species identification and classification","authors":"Mulugeta Adibaru Kiflie ,&nbsp;Durga Prasad Sharma ,&nbsp;Mesfin Abebe Haile","doi":"10.1016/j.jaim.2024.100987","DOIUrl":"10.1016/j.jaim.2024.100987","url":null,"abstract":"<div><h3>Background</h3><div>Medicinal plants are crucial for traditional healers in preparing remedies and also hold significant importance for the modern pharmaceutical industry, facilitating drug discovery processes. Accurate and effective identification and classification of Ethiopian indigenous medicinal plants are vital for their conservation and preservation. However, the existing identification and classification process is time-consuming, and tedious, and demands the expertise of specialists. Botanists traditionally rely on traditional and experience-based methods for identifying various medicinal plant species.</div></div><div><h3>Objective</h3><div>This research aims to develop an efficient deep learning model through transfer learning for the identification and classification of Ethiopian indigenous medicinal plant species.</div></div><div><h3>Materials and methods</h3><div>A custom dataset of 1853 leaf images from 35 species was prepared and labeled by botanist experts. Experiments have been done with the use of pretrained deep learning models, specifically VGG16, VGG19, Inception-V3, and Xception.</div></div><div><h3>Results</h3><div>The results demonstrate that fine-tuning the models significantly improves training and test accuracy, indicating the potential of deep learning in this domain. VGG19 outperforms other models with a test accuracy of 94%, followed by VGG16, Inception-V3, and Xception with test accuracies of 92%, 91%, and 87%, respectively. The study successfully addresses the challenges in the identification and classification of Ethiopian indigenous medicinal plant species.</div></div><div><h3>Conclusion</h3><div>With an inspiring accuracy performance of 95%, it can be concluded that fine-tuning emerged as a highly effective strategy for boosting the performance of deep learning models.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 100987"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved quality of life of a patient with refractory aggressive Natural Killer/ T-cell lymphoma (NKTCL) on adjunct Ayurvedic treatment protocol: A case report of ten-years follow-up","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Arvind Kulkarni,&nbsp;Vasanti Godse,&nbsp;Shrinivas Datar,&nbsp;Swapna Kulkarni,&nbsp;Sushama Bhuvad,&nbsp;Sandeep Chavan","doi":"10.1016/j.jaim.2024.100968","DOIUrl":"10.1016/j.jaim.2024.100968","url":null,"abstract":"<div><div>In an Indian female patient diagnosed as an aggressive refractory Natural Killer/T-cell Lymphoma treated with radiotherapy followed by chemotherapy, long term overall survival (OS) of 10 years was achieved. She refused Bone Marrow Transplant (BMT) after relapse and opted 2nd line chemotherapy. After completion of conventional treatment, she started Oral Ayurvedic Medicines (OAM) which possess immunomodulatory, anti-inflammatory, and to a certain extent anti-cancer activity.</div><div>This female patient was diagnosed with Stage IIE NK/T-cell Lymphoma and treated with radiotherapy from May to July 2011 followed by 6 cycles of R – CHOP Protocol from August to November 2011. Within 3 months after completion of conventional treatment, the patient presented with a recurrence of palatal ulcer and the appearance of tender subcutaneous nodules on both legs. She visited Cancer Hospital for a further line of treatment. Her histopathological report of soft palate ulcer showed suspicion of Non-Hodgkin's Lymphoma (NHL) and a subcutaneous nodule over her right leg revealed cutaneous involvement by NHL. Oncologist advised Bone Marrow Transplant (BMT) after taking into consideration an early relapse and aggressiveness of the disease. However, the patient refused BMT and opted 6 cycles of SMILE protocol chemotherapy taken from October 2012 to January 2013. The patient is under OAM of our centre consisting of a well-planned and personalized 6 sets of herbo-mineral metallic Ayurvedic medicines to minimize the side effects of chemotherapy as well as to boost immunity to prevent further recurrence of the disease. Her quality of life is improved significantly without any disease recurrence to date.</div><div>In this case of Refractory Natural Killer/T-cell Lymphoma having poor prognosis, 10 years OS after starting Ayurvedic treatment is reported. It has been achieved by personalized adjunct Ayurvedic treatment consisting combination of oral herbo-mineral metallic medicines.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 100968"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic perspective of dietary risk factors of colorectal cancers - A hospital-based case control study","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Vasanti Godse,&nbsp;Shweta Gujar,&nbsp;Sneha Dalvi,&nbsp;Swapna Kulkarni,&nbsp;Sushama Bhuvad,&nbsp;Nilambari Sardeshmukh,&nbsp;Bhagyashree Sardeshmukh,&nbsp;Dhananjay Deshpande,&nbsp;Vinita Awalkanthe,&nbsp;Amruta Salunkhe,&nbsp;Anita Redekar,&nbsp;Suchita Vaidya,&nbsp;Sandeep Chavan","doi":"10.1016/j.jaim.2024.100969","DOIUrl":"10.1016/j.jaim.2024.100969","url":null,"abstract":"<div><h3>Background</h3><div>The rising prevalence of colorectal cancer (CRC) may be attributed to various nutritional and behavioural factors, making both factors as important topics for discussion to the layman and the oncology community.</div></div><div><h3>Objective</h3><div>To explore additional dietary risk factors, other than those already known, according to the Ayurvedic perspective in CRC patients.</div></div><div><h3>Methods</h3><div>Detail dietary data was collected from 420 patients of CRC and 116 healthy volunteers registered at our institute with the help of a food frequency questionnaire. Descriptive analysis was done by plotting radar charts, whereas the logistic regression models were used to calculate the adjusted Odd Ratios (ORs) associated with consumption of green chilli, red chilli powder and curd, individually and in combinations.</div></div><div><h3>Results</h3><div>The controls in the present study were younger, had more males, the majority of them belonged to middle- and lower-income groups and had a family history of cancer as compared with cohort of case studies. Green chilli consumption was found to be the maximum within the lower-income group (n = 18, 66.67%), while that of red chilli (n = 150, 48.23%), and curd (n = 107, 34.04%) within the middle class. Maximum consumption of green chillies (Males n = 48, 29.27%; Females n = 36, 21.95%), red chillies (Males n = 40, 29.85%; Females n = 16, 24.61%) and curd (Males n = 31, 28.97%) was observed in the age group 46 to 60 irrespective of sex. Tobacco was found to be the most common addiction in all groups. The maximum number of patients frequently consuming these three dietary items presented majorly with rectal cancer, and liver metastasis and were in advanced grade and stage of cancer. Curd and curd with red chilli powder had a significant association with the development of CRC with an OR of 2.7280 (95% CI 1.6346 to 4.5531) and 5.0806 (95% CI 2.4015 to 10.7485), respectively, which was highly significant (p &lt; 0.0001). Green chilli was notably an associated risk with an OR of 2.0095 (95% CI 1.3258 to 3.0458), which was also statistically significant (p = 0.001). Red chilli powder and green chilli with curd had ORs as 1.6917 (95% CI 1.1105 to 2.5771) and 2.1778 (95% CI 1.1591 to 4.0918) with p = 0.0144 and 0.0156, respectively.</div></div><div><h3>Conclusion</h3><div>In the present study<strong>,</strong> green chilli, red chilli, and curd are identified as additional dietary risk factors for colorectal cancers, owing to their ability to produce chronic inflammation leading to various inflammatory conditions including cancer.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 6","pages":"Article 100969"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}