Journal of Ayurveda and Integrative Medicine最新文献

{"title":"In vitro anti-inflammatory and in silico anti-viral assessment of phytoconstituents in polyherbal Ayurvedic formulation ‘Arogyamrita Kwath’","authors":"Akash Dey ,&nbsp;Akash G. Kendre ,&nbsp;Madhu babu Dande ,&nbsp;Yogita B. Tandalekar ,&nbsp;Shreyanshi Kulshreshtha ,&nbsp;Amit Srivastava ,&nbsp;Alok Goyal ,&nbsp;Ramadas Maganti ,&nbsp;Sumit Srivastava ,&nbsp;Prasad V. Bharatam ,&nbsp;Sanjay M. Jachak","doi":"10.1016/j.jaim.2024.101076","DOIUrl":"10.1016/j.jaim.2024.101076","url":null,"abstract":"<div><h3>Background</h3><div>Arogyamrita Kwath (AMK) is a polyherbal decoction comprising ten medicinal plants, <em>viz</em>., <em>Albizia lebbeck</em>, <em>Andrographis paniculata</em>, <em>Tinospora cordifolia</em>, <em>Adhatoda vasica</em>, <em>Solanum xanthocarpum</em>, <em>Curcuma longa</em>, <em>Glycyrrhiza glabra</em>, <em>Terminalia bellirica</em>, <em>Withania somnifera</em> and <em>Trachyspermum ammi</em>. The plants of the AMK formulation are traditionally used for the treatment of inflammation and respiratory ailments, but no scientific evidence has been reported so far for this formulation.</div></div><div><h3>Objectives</h3><div>To evaluate anti-inflammatory activity of AMK formulation <em>in vitro</em> and its fractions and to predict <em>in silico</em> anti-viral activity of identified potential phytoconstituents.</div></div><div><h3>Materials and methods</h3><div>The MTT cell cytotoxicity assay, nitric oxide (NO) inhibition assay and cytokines assay were carried out at concentrations 100 and 200 μg/mL. The phytoconstituents were identified by UPLC-PDA and UPLC-HRMS analyses. For pharmacoinformatics study molecular docking and molecular dynamics methods were used.</div></div><div><h3>Results</h3><div>The study revealed that AMK significantly inhibited NO in comparison to dexamethasone (100 μg/mL) and pro-inflammatory cytokines in RAW264.7 cells. The three fractions, <em>n</em>-hexane, EtOAc and <em>n</em>-BuOH prepared from the AMK formulation were non-cytotoxic against RAW264.7 murine macrophage cells during MTT cytotoxicity assay and showed satisfactory results during cytokines assay. Ethyl acetate fraction contains active phytoconstituents in appreciable quantities. 16 phytoconstituents have been identified by UPLC-HRMS analysis in the formulation and four phytocompounds were quantified by UPLC-PDA. Molecular dynamics study helped in identifying two macromolecular targets (viral replicase and the membrane protein), which are relatively more important.</div></div><div><h3>Conclusion</h3><div>In the present study, anti-inflammatory activity of AMK was evaluated and the claimed anti-viral property was re-confirmed by molecular modelling in this work. The results clearly established that AMK showed remarkable anti-inflammatory and anti-viral activities.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101076"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized double blind placebo controlled multicentric clinical trial of Ayush M-3 in the management of migraine- A study protocol","authors":"Shweta Chaudhary ,&nbsp;Shruti Khanduri ,&nbsp;Sunita Mata ,&nbsp;B.C.S. Rao ,&nbsp;Kuljeet Singh Anand ,&nbsp;R. Kishore Kumar ,&nbsp;K.G. Sudha Kumari ,&nbsp;Bidhan Mahajan ,&nbsp;Rakesh Kumar Rana ,&nbsp;Richa Singhal ,&nbsp;Shweta Mata ,&nbsp;Renu Makhija ,&nbsp;Bharti ,&nbsp;N. Srikanth ,&nbsp;K.S. Dhiman ,&nbsp;Rabinarayan Acharya","doi":"10.1016/j.jaim.2024.101054","DOIUrl":"10.1016/j.jaim.2024.101054","url":null,"abstract":"<div><h3>Background</h3><div>Migraine is acknowledged as an intricate and incapacitating neurological malady, profoundly exerting a potent influence on the health-related quality of life of patients causing disability, and augmented burden on families, and entire communities. Notwithstanding the strides made in the field of headache disorder management, there remains a cohort of migraine-afflicted patients who do not encounter satisfactory alleviation. This emphasizes the need for alternative systems in addressing the issue and there is a growing interest in exploring Indian system of medicine to address migraine symptoms. <strong>Objective:</strong> Due to the dearth of prospective, high-quality randomized controlled trials, this protocol aims to conduct a scientific study of the polyherbal formulation ‘Ayush M3’ to assess its safety and efficacy in patients suffering with migraine.</div></div><div><h3>Materials and Methods</h3><div>A prospective, randomized, double blind, parallel-group, placebo controlled, multi – centric, two-arm, exploratory study has been designed to enrol a total of 360 patients at three sites. Migraine patients with or without aura diagnosed as per International Headache Society-ICHD-III below Grade III of MIDAS will be randomized in a 1:1 ratio and administered the trial drug, Ayush M − 3 or placebo for twice a day after food for 16 weeks.</div></div><div><h3>Outcome measures</h3><div>The primary outcomes measures for the study will be changes in the character of disease in terms of frequency, intensity of headache as per VAS (0–10) and duration of episode of headache. Secondary outcome measure will be changes in MIDAS, MSQ2.1, changes in associated symptoms of migraine, change in the use of analgesics/symptom alleviating medication &amp; Change in the required dose/withdrawal of Anti-hypertensive drugs if any. Assessment will be conducted on an interval of 28 days till 16 weeks and an intervention free follow up at the end of week 20.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101054"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurveda management of post TURP urethral stricture: A case report","authors":"T. Sushendra ,&nbsp;Foram P. Joshi ,&nbsp;Hetal L. Nakrani ,&nbsp;Manisha Kapadiya ,&nbsp;Saurabh P. Patel","doi":"10.1016/j.jaim.2024.101084","DOIUrl":"10.1016/j.jaim.2024.101084","url":null,"abstract":"<div><div>Post TURP (Trans Urethral Resection of Prostate) Urethral stricture incident rates have been reported between 2.2 and 9.8%. Weak urine stream, recurrent urethral infections, dysuria, retention of urine, etc. are the chief presenting complaints of the clinical cases. Sushruta described 12 types of <em>Mootraghata</em> (∼clinical conditions stating obstructive uropathies). Lower Urinary Tract Symptoms (LUTS) have been provided with separate diagnostic notation with its description in <em>Mootraghata</em>. Sushruta narrated <em>Mootrotsanga</em>-a clinical condition confirming obstruction of urine in the lower urinary tract developing LUTS. Sushruta recommended <em>Uttarabasti</em> (intra-urethral douching) as a line of treatment to get rid of obstructive uropathies of various origins. This case is about a 70-year-old nondiabetic, nonhypertensive male who reported a 2-month history of weak urinary stream, burning micturition, and increased micturition frequency. The patient was diagnosed with stricture at the distal penile urethra near the external urethral meatus and stricture at the junction of the middle and posterior urethra. This case was managed by, <em>Sadhyo Virechana</em> (Therapeutic purgation)<em>,</em> followed by <em>Uttarbasti</em> (intra-urethral douche) procedure with <em>Jatyadi</em> oil and other adjuvent Ayurveda medicaments like <em>Eranda Bhrishta Haritaki, Gokshuradi Guggul</em> and <em>Varunadi Kwatha</em> for 21 days. Encouraging outcome was achieved in terms of complete reversal from Urethral stricture and evident with Ascending Urethrogram (AUG) report. Since the last 1 years' follow-up, the patient has been living symptom-free. LUTS and especially, stricture pathologies can be managed through safe and noninvasive procedures like <em>Uttarabasti</em>.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101084"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalogram analysis on alpha/beta and theta/beta ratios due to shirodhara","authors":"Yogeshwar Dasari ,&nbsp;Lakshmana Rao Chebolu ,&nbsp;Venkatesh Balasubramanian","doi":"10.1016/j.jaim.2024.101094","DOIUrl":"10.1016/j.jaim.2024.101094","url":null,"abstract":"<div><h3>Background</h3><div><em>Shirodhara</em> is a brain relaxation therapy. The treatment induces a relaxed state with awareness that results in treating neurological conditions like mental stress (depression/anxiety/hypertension) and some of its beneficial side effects are soothing the central nervous system.</div></div><div><h3>Objectives</h3><div>In the present study, the investigation aimed to analyze the ratios of brain waves, particularly focusing on the frontal region.</div></div><div><h3>Materials and Methods</h3><div>In this study, <em>Shirodhara</em> with “<em>Ksheerabala thailam</em>” medicinal oil was conducted on 16 participants and pre-post treatment brain signals were collected using an EEG acquisition tool and it was found that treatment induced relaxation aspects were observed among participants.</div></div><div><h3>Results and Conclusion</h3><div>Welch's Fast Fourier transform (FFT) was used to analyze the EEG signals in order to obtain power spectral density (PSD) features, which indicated a signal's power dispersed across a range of frequencies. The effectiveness of treatment has been evaluated by examining the spectral power ratios of alpha/beta, theta/beta in the frontal region of the brain and physiological and psychological parameters.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101094"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-invasive Ayurveda management of venous leg ulccer- A case report","authors":"Archana Muraleedharan,&nbsp;Sree R. Nair,&nbsp;P.N. Rajeshwari","doi":"10.1016/j.jaim.2024.101073","DOIUrl":"10.1016/j.jaim.2024.101073","url":null,"abstract":"<div><div>Venous leg ulcer (VLU) is a severe complication of chronic venous insufficiency that commonly affects older individuals. It is a long-standing consequence of venous insufficiency and accounts for 70%–80% of lower limb ulcers seen in outpatient departments. These ulcers are often unresponsive to treatment and can significantly impact patients' quality of life, causing pain, sleep disturbances, and decreased mobility. Managing varicose leg ulcers is a significant challenge for physicians.A 55-year-old male presented with symptoms including pain, stiffness, discoloration, swelling in the left lower limb, and a history of non-healing ulcer. The patient was treated with <em>Patrad</em><em>a</em><em>na</em> using leaves of <em>Ricinus communis</em> (<em>Eranda patra</em>) and <em>Grihadhum</em><em>a</em><em>di lepa</em> along with oral medications such as <em>Triphal</em><em>a</em> <em>Guggulu</em> and <em>Gandhaka Ras</em><em>a</em><em>yana</em>. Each day, the change was carefully observed and documented, revealing a notable improvement by the end of the treatment (10 days). The pain, swelling, and stiffness exhibited significant reduction, accompanied by wound healing after the first follow-up of 14 days. The complete wound healing was achieved and quality of life showed improved. The patient has beenunder observation and has not reported any recurrence of ulcer in the 4 months of follow up.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101073"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe and effective management of psoriasis through Ayurveda: A case report","authors":"Guruprasad C. Nille ,&nbsp;Monisha Bhuyan ,&nbsp;Laxmi Narayan Gupta ,&nbsp;Anand Kumar Chaudhary","doi":"10.1016/j.jaim.2024.101091","DOIUrl":"10.1016/j.jaim.2024.101091","url":null,"abstract":"<div><div>Ayurveda, an ancient system, offers in-depth insights into various skin disorders. It provides detailed understanding of causative factors and pathomechanisms, along with time-tested traditional treatments based on its principles. We report a 16-year chronic case of psoriasis (36-year-old male patient) with plaques and peeling erythrodermic skin rashes over the back and front of the trunk area and both legs. The scalp area and nail beds were also affected. The early involvement of joints was also noted. A two-year multimodal Ayurveda treatment has shown notable efficacy in managing chronic plaque and erythrodermic psoriasis, with no reported adverse events or side effects. The progressive events were documented in the form of photographs with the proper consent of the patient. The Ayurveda medicines, strict dietary regimen, and regular follow-ups together resulted in promising outcomes, revalidating the potential of Ayurveda in controlling psoriasis and its complications.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101091"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Yograj Guggulu, Ashwagandha Churna and Narayana Taila in management of Osteoarthritis Knee: A study in tribal dominant community","authors":"Kalpana Kachare ,&nbsp;Deepa Makhija ,&nbsp;Abha Sharma ,&nbsp;Sunita ,&nbsp;N. Srikanth ,&nbsp;B.S. Sharma ,&nbsp;Rakesh Rana ,&nbsp;Arunabh Tripathi ,&nbsp;B.C.S. Rao ,&nbsp;Purnendu Panda ,&nbsp;Ekta ,&nbsp;Raghavendra Naik ,&nbsp;K. Nishanth ,&nbsp;U.R. Shekhar Namburi ,&nbsp;Vimal Tiwari ,&nbsp;S.B. Singh ,&nbsp;Monika ,&nbsp;P. Srinivas ,&nbsp;Vipin Sharma ,&nbsp;Anil Avhad ,&nbsp;Abhaydev","doi":"10.1016/j.jaim.2024.101077","DOIUrl":"10.1016/j.jaim.2024.101077","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) is the most prevalent joint disease and a major cause of joint impairment and physical debility, common in elderly, women and laborious workers. The available non-steroidal anti-inflammatory drugs (NSAID) are being prescribed to manage the condition; however, newly discovered alternatives are looked upon by the practitioners. Thus, the study was aimed to provide an effective and safer alternative through Ayurveda for the management of OA.</div></div><div><h3>Objective</h3><div>To document the role of the selected Ayurveda formulations in the management of OA and to assess the tolerability of the formulations.</div></div><div><h3>Material and methods</h3><div>It was an open-label, multicentric, single-arm, prospective, study conducted at 14 peripheral institutes of the Central Council for Research in Ayurvedic Sciences, New Delhi. 483 participants of any gender between the age 40 to 65 years diagnosed with OA knee as per the ACR diagnostic criteria (2012) and willing to provide consent were enrolled in the study. Oral administration of Ayurvedic formulations Yograj Guggulu, Ashwagandha Churna and the local application of Narayana Taila was given for 12 weeks and assessment was done by means of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Modified-CRD, Pune version Score, Visual Analogue Scale score and disease-specific symptoms on 28th, 56th, 84th and 112th day.</div></div><div><h3>Results</h3><div>Significant change (P&lt;0.001) was observed in WOMAC score, VAS score and cardinal symptoms of OA knee. No adverse events reported in the study and the study drugs were well tolerated by the participants.</div></div><div><h3>Conclusion</h3><div>The study substantiates that administration of Yograj guggulu, Ashwagandha Churna and Narayana Taila, is well acceptable and tolerable. The interventions effectively alleviate the cardinal symptoms of OA knee.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101077"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting cell cycle arrest in breast cancer by phytochemicals from Caryto urens L. fruit ethyl acetate fraction: in silico and in vitro validation","authors":"Ghanshyam Parmar,&nbsp;Jay Mukesh Chudasama,&nbsp;Ashish Shah,&nbsp;Chintan Aundhia,&nbsp;Sunil Kardani","doi":"10.1016/j.jaim.2024.101095","DOIUrl":"10.1016/j.jaim.2024.101095","url":null,"abstract":"<div><h3>Background</h3><div><em>Caryota urens</em>, also known as Shivjata, has been documented in ancient Indian texts for its therapeutic benefits, addressing conditions from seminal weakness to gastric ulcers. This study aims to investigate its contemporary medicinal potential in treating breast cancer.</div></div><div><h3>Objectives</h3><div>The study focuses on exploring the therapeutic potential of <em>Caryota urens</em> fruit against breast cancer, specifically targeting cell cycle genes CDK1, CDC25A, and PLK1 through bioinformatics, network pharmacology, and in vitro validation.</div></div><div><h3>Materials and methods</h3><div>Using mass spectrometry and nuclear magnetic resonance (NMR), 60 key phytoconstituents from <em>Caryota urens</em> fruit were identified. Bioinformatics analysis, integrating Gene Cards and GEO databases, 15,474 breast cancer-associated genes focusing on the HR+/HER2-subtype were identified. Molecular docking and qPCR validated the interactions of key phytoconstituents, particularly Episesamin, with CDK1, CDC25A, and PLK1. In vitro studies were conducted on the MCF7 cell line, supplemented by ROC and survival analyses to evaluate diagnostic and therapeutic potential.</div></div><div><h3>Results</h3><div>The bioinformatics analysis identified CDK1, CDC25A, and PLK1 as pivotal genes regulating cell cycle progression and breast cancer tumorigenesis. Network pharmacology and in vitro studies indicated that phytoconstituents, especially Episesamin, downregulated these genes in breast cancer cells. Molecular docking and qPCR confirmed these interactions, and ROC and survival analyses underscored their diagnostic and therapeutic significance.</div></div><div><h3>Conclusions</h3><div>This study suggests that <em>Caryota urens</em> fruit extract, particularly Episesamin, may inhibit breast cancer metastasis by downregulating CDK1, CDC25A, and PLK1, offering promising new strategies for targeting the cell cycle in breast cancer and emphasizing the value of integrating bioinformatics with experimental methods in cancer research.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101095"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of self-acupressure on quality of life and abdominal pain severity among patients with inflammatory bowel disease: A randomized sham-controlled trial","authors":"Nahid Rajai ,&nbsp;Zahra Abbasi ,&nbsp;Amir Hosein Pishgooie ,&nbsp;Fatemeh Teymouri ,&nbsp;Mohammad Imanipour","doi":"10.1016/j.jaim.2024.101080","DOIUrl":"10.1016/j.jaim.2024.101080","url":null,"abstract":"<div><h3>Background</h3><div>Acupressure is being used by patients to relieve functional gastrointestinal disorders.</div></div><div><h3>Objective</h3><div>The impact of acupressure on quality of life (QoL) and pain has been shown in patients with both acute and chronic conditions. However, its effects on individuals with inflammatory bowel disease (IBD) remain uncertain. This trial aims to explore the potential effects of self-acupressure on QoL and abdominal pain severity in IBD patients.</div></div><div><h3>Methods</h3><div>This randomized sham-controlled trial involved 56 outpatients with IBD referred to the emergency department, who were randomly assigned to either an acupressure group or a sham group. All patients received standard care along with daily follow-up calls. Those in the acupressure group applied pressure at four specific points, while the sham group engaged in superficial self-touch at corresponding points. Both interventions occurred three times daily for four weeks. The quality of life was assessed using the IBDQ-9 questionnaire and a visual analog scale (VAS) at both baseline and endpoint.</div></div><div><h3>Results</h3><div>The mean IBDQ-9 score was significantly higher in the acupressure group compared to the sham group at the trial's end (P &lt; 0.001). Likewise, the mean VAS score was notably lower in the acupressure group at the endpoint (P &lt; 0.001). Additionally, the change in mean IBDQ-9 scores from baseline to endpoint favored the acupressure group significantly (P &lt; 0.001), and the same significant difference was observed for the mean VAS score change (P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Daily follow-up-guided self-acupressure may improve quality of life and alleviate abdominal pain in IBD sufferers.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101080"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plants used in Ayurveda for Jwara or fever: A review of their antiviral studies","authors":"Athira Bindhu,&nbsp;Ajikumaran Nair S,&nbsp;Anil John Johnson,&nbsp;Sabulal Baby","doi":"10.1016/j.jaim.2024.101085","DOIUrl":"10.1016/j.jaim.2024.101085","url":null,"abstract":"<div><div>Two of the earliest treatises in <em>Ayurveda</em>, the ‘<em>Charaka Samhita</em>’ and the ‘<em>Sushruta Samhita</em>’, describe numerous medicinal plants used in the treatment of <em>Jwara</em> (fever). Systematic studies carried out on these plants registered for ‘<em>Jwara</em>’ are of high significance in antiviral drug development.</div><div>This article is a comprehensive review of the antiviral studies on medicinal plants listed for ‘<em>Jwara</em>’ in ‘<em>Charaka</em><em>-Sushruta Samhita</em><em>s’</em>, their antiviral entities and modes of action.</div><div>The botanical names of the medicinal plants used for ‘<em>Jwara</em>’ were elucidated from their Sanskrit names in ‘<em>Charaka-Sushruta Samhitas</em>’ and their subsequent interpretations. Antiviral studies on these plant species and their constituents were compiled from the literature retrieved from Scopus, PubMed, Google Scholar and other databases. Antiviral activities against various viruses were evaluated based on EC₅₀/IC₅₀/LC₅₀ values, high percent inhibitions and molecular docking parameters displayed by their extracts, secondary metabolites, short peptides, polyphenols, anthocyanins and polysaccharides. Their modes of action were also evaluated.</div><div>Strikingly, in antiviral studies very low EC₅₀/IC₅₀/LC₅₀ and high percent inhibitions were demonstrated by medicinal plants widely used as traditional medicines, vegetables, foods and flavours. Secondary metabolites (including essential oils), anthocyanins, polyphenols, short peptides and polysaccharides in these plants illustrated antiviral activities by hampering membrane permeability, cellular functions and replication cycle of harmful viruses.</div><div>Medicinal plants used for fever in <em>Ayurveda</em> could be used as natural sources of lead molecules for antiviral drug development. Antiviral activities displayed by these plants are justifying the ancient wisdom traditionally demonstrated over centuries.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101085"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}