Journal of Ayurveda and Integrative Medicine最新文献

{"title":"A holistic Ayurvedic approach to manage persistent depressive disorder, Vishada—A case report","authors":"Aqsa Zarin Khan ,&nbsp;Jibi Varghese ,&nbsp;Chandrakumar Deshmukh ,&nbsp;Prashant Khade ,&nbsp;Sana Khanam Mirza ,&nbsp;Manna Mathew","doi":"10.1016/j.jaim.2025.101243","DOIUrl":"10.1016/j.jaim.2025.101243","url":null,"abstract":"<div><div>Persistent Depressive Disorder (PDD), formerly known as Dysthymia, is a chronic and enduring form of depression. In contemporary society, the pressures of modern lifestyles, pervasive feelings of uncertainty and insecurity, the fast pace of life, competition in various domains, suboptimal hygiene practices, and food adulteration have become primary contributors to the disruption of mental and physical well-being. Persistent Depressive Disorder (PDD) can be correlated to <em>Vishada</em> in Ayurveda. This article presents a case study of a patient diagnosed with PDD (Persistent Depressive Disorder) as per DSM-5 criteria. Management was planned with integrative treatment consisting of <em>Sattvavajaya chikitsa</em> (Ayurveda psychotherapy), <em>Shamana Chikitsa</em> (oral medicines), and the skillful implementation of <em>Viddhakarma,</em> thus illustrating its efficacy in depression. The treatment persisted for six months, and the intervention outcome demonstrated a decrease in Hamilton Depression Rating scores, declining from 16 to 5 with a reduction of symptoms by the end of the six months of intervention. <em>Viddhakarma</em>, one among the eight <em>shastra karma</em>, is regarded as one of the most effective para-surgical procedures for regulating the vitiated <em>dosha</em> described by <em>Acharya</em> Shushrut and <em>Acharya</em> Vagbhata. This article is a sincere effort to emphasize the significance and application of <em>Viddhakarma</em> therapy along with the conventional Ayurveda treatment in <em>manasik vikaras</em>. Furthermore, the observed improvements were sustained even throughout the non-interventional observation period.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101243"},"PeriodicalIF":1.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating macro-microscopy, DNA barcoding and HPTLC for quality assessment of berberine containing botanicals traded as Maramanjal/Daruharidra","authors":"Sunil Kumar Koppala Narayana ,&nbsp;Pushkar Kaira ,&nbsp;Mahima Karthikeyan ,&nbsp;Murugammal Shanmugam ,&nbsp;Susikumar Sundharamoorthy ,&nbsp;Remya Andalil ,&nbsp;Divya Kallingil Gopi ,&nbsp;Radha Prakasam ,&nbsp;Shakila Ramachandran ,&nbsp;Kanagarajan Arumugam","doi":"10.1016/j.jaim.2025.101192","DOIUrl":"10.1016/j.jaim.2025.101192","url":null,"abstract":"<div><h3>Background</h3><div><em>Daruharidra/Maramanjal</em> is one of the most popular shrub used in Ayurveda, Siddha and other Indian medicinal systems. More than one botanical source is traded under this name, predominantly <em>Berberis aristata</em> and <em>Coscinium fenestratum</em> with an annual trade of 1000–2000 metric tonnes. The herbal drug trade is often reported with misidentification, adulteration and/or substitution issues due to morphological resemblance and confusion in vernacular names. This work aimed to integrate macro-microscopic, DNA marker strategies and phytochemical assay to differentiate <em>Berberis aristata</em> from its traded sources.</div></div><div><h3>Material and methods</h3><div>Thirteen marketed samples and one authentic field sample from natural habitat were collected from various regions of the Indian market under the trade name <em>Maramanjal/Daruharidra</em>. The traditional identification methods included macro-microscopic and phytochemical screening by High-Performance Thin Layer Chromatography (HPTLC). Additionally, DNA barcode-based molecular identification and phylogenetic analysis were done using the ITS2 (Internal Transcribed Spacer 2) marker.</div></div><div><h3>Results</h3><div>The macroscopic observations revealed 80 % ad-mixing of various allied botanicals in addition to accepted north Indian and south Indian sources such as <em>B. aristata</em> and <em>C. fenestratum</em> respectively. DNA barcoding enabled the identification of genuine and adulterated raw drugs from the collected samples. The HPTLC quantification revealed the presence of berberine in all 14 samples varying from 1.12 % to 26.33 %.</div></div><div><h3>Conclusions</h3><div>The macro-micro, HPTLC, and DNA barcoding helped in the identification of adulteration and substitution practices in this highly traded botanical drug. DNA barcoding can prove an effective tool for discovering the adulteration and substitution of <em>Maramanjal/Daruharidra</em> and this is its first report on the application of morphology, microscopy, phytochemical analysis, and DNA markers in differentiating these traded species.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101192"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pedagogy experiments for Ayush academia","authors":"Girish Tillu","doi":"10.1016/j.jaim.2025.101273","DOIUrl":"10.1016/j.jaim.2025.101273","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101273"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of yoga on pulmonary functions in clinical population: A systematic review and meta-analysis of randomized controlled trials (RCTs)","authors":"Vipin K. Rathore,&nbsp;Sandeep Singh,&nbsp;Nidheesh Yadav","doi":"10.1016/j.jaim.2025.101189","DOIUrl":"10.1016/j.jaim.2025.101189","url":null,"abstract":"<div><div>This study aims to investigate the impact of yoga practice on pulmonary and respiratory functions in clinical populations. A thorough search was carried out in the Cochrane Library, PubMed, Science Direct databases, and Google Scholar, using the keywords “Yog∗” and “pulmonary functions”, covering the period from January 2010 to December 2022. Studies that aligned with PRISMA recommendations were included. The Cochrane risk-assessment tool was employed to assess bias risk. We calculated weighted mean differences (WMDs) with 95 % confidence intervals (CIs) and used the I² test to assess heterogeneity. Initially, 529 studies were found through the search, with 10 randomized controlled trials (RCTs) involving 1007 patients meeting the inclusion criteria for quality assessment and meta-analysis. The results indicated that yoga intervention (YI) significantly improved FVC% (WMD: 3.03 L, 95 % CI: 1.71, 4.35, P &lt; 0.00001), FEV1 (WMD: 0.47 L, 95 % CI: 0.43, 0.51, P &lt; 0.00001), and FEV1% (WMD: 5.74 L, 95 % CI: 4.47, 7.01, P &lt; 0.00001) when compared to control groups. However, no significant effect was observed on FVC (WMD: 0.23 L, CI: 0.16, 0.62. P = 0.25), PEFR (WMD: 0.49, CI: 0.70, 1.67, P = 0.42), MVV (WMD: 9.01, CI: 3.92, 21.94, P = 0.17), and FEV1/FVC (WMD: 3.17, CI: 1.15, 7.48, P = 0.15) as a result of YI. Based on the limited evidence and meta-analysis conducted, YI demonstrated a positive effect on pulmonary function in clinical populations and could be considered as an adjunct therapy for individuals with various respiratory diseases. Further rigorous research with larger sample sizes is necessary to confirm the long-term benefits of yoga.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101189"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report on Ayurvedic management of progressive bulbar palsy-A rare amyotrophic lateral sclerosis phenotype","authors":"Sinimol Thekkekkoottumughath Peethambaran ,&nbsp;Abhayadev Ashokan ,&nbsp;Varanasi Subhose","doi":"10.1016/j.jaim.2025.101176","DOIUrl":"10.1016/j.jaim.2025.101176","url":null,"abstract":"<div><div>This case report is the description of a devastating illness, Progressive Bulbar Palsy (PBP) of a sixty-seven years old male patient. He presented with complaints of slurred speech, hearing impairment, generalised weakness of limbs, weakened grip to hold objects in hand, difficulty to walk with normal speed, frequent dizzy feeling while walking, severe fatigue, increased anger, heaviness of head, depression, anxiety, decreased memory and headache for 1 year. When he consulted conventional medicine, in Magnetic Resonance Imaging (MRI) of brain, only ‘Partial empty sella’ and age related mild cerebral atrophy was detected and the patient was diagnosed PBP clinically. They prescribed Riluzole 50 mg tablet twice a day and Fluoxetine 10mg capsules at night time for 3 months, but obtained no relief for symptoms and consulted this Out Patient Department (OPD). In Ayurvedic parlance, PBP resembles conditions like <em>Kaphavruta vata</em>. In this patient, <em>Pittavritavata</em> symptoms like <em>bhrama</em> (∼dizziness) was also present in increased severity. Diagnosis was done with the aid of Gold Coast diagnostic criteria. Internal and external medications with properties alleviating <em>avarana</em> (∼occlusion) of <em>vata</em> by <em>kapha</em> and <em>pitta</em>, <em>shodhana</em> (∼expelling the aggravated doshas and cleanses the body internally), rejuvenating <em>(Rasayana) properties,</em> for overall strengthening of nervous system and musculoskeletal system, enhancing balance and coordination, improving speech and memory were used. The assessment was done before and after the treatment by ‘Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R). The score before and after the treatment was 35 and 45 respectively out of 48. The treatment helped to increase the quality of life exceptionally as symptomatic relief was obtained. As it is a devastating disorder with poor prognosis and most probably will lead to death, it is advisable to repeat the treatments in regular intervals, depending on the recurrence of symptoms, if any.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101176"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Atherosclerotic Cardiovascular disease in the light of Ayurveda","authors":"Maanasi Menon ,&nbsp;Sushma Naranappa Salethoor ,&nbsp;Thushara Madathil ,&nbsp;Akhilesh Shukla","doi":"10.1016/j.jaim.2025.101186","DOIUrl":"10.1016/j.jaim.2025.101186","url":null,"abstract":"<div><div>Atherosclerotic cardiovascular disease (ASCVD) is the malady that claims most human lives around the world by literally cutting off their heart's blood supply. Unwholesome diet, sedentary lifestyle and psychological stress are the major risk factors leading to this condition. Even with technological and medical advancements, the burden of this disease has only aggravated further especially with the COVID pandemic also contributing to trigger this condition. There is an urgent need to find better solutions to combat this disease in such circumstances. The Indian traditional healthcare system, Ayurveda has a unique perspective of the heart and heart disease which when understood parallelly along with modern medical knowledge may offer better solutions. The descriptions of <em>Kaphaja Hridroga</em> in Ayurveda can be correlated to ASCVD, and this article is an effort to develop a synergistic understanding of the aetio-pathogenesis of ASCVD in the light of Ayurveda. Ayurveda management principles give more emphasis on prevention and non-pharmacological approaches such as diet and lifestyle modifications along with medical management and these principles of management of <em>Hridroga</em> can be tactfully integrated into conventional therapy for providing a more wholesome care.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101186"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Oligo-teratospermia with Vajikarana Chitkitsa resulting in healthy natural conception: A case report.","authors":"Swarda R Uppin, T U Aravinth","doi":"10.1016/j.jaim.2025.101190","DOIUrl":"10.1016/j.jaim.2025.101190","url":null,"abstract":"<p><p>Oligo-teratozoospermia is a condition affecting the normal sperm count and morphology leading to male factor infertility, majorly resulting due to improper lifestyle adaptations. In Ayurveda literature, the condition is well elaborated as Ksheenashukra having specified treatment modalities. This paper presents a case of infertile couple where in the male was diagnosed with Oligo-teratozoospermia, and was advised for ART due to teratogenecity. The patient approached Ayurveda fertility centre and was subjected to Ayurveda treatment with initial counseling, followed by Shodhana chikitsa and 2 courses of Vajikarana aushadhi prayoga. Within 3 months, the outcome resulted from Oligo-teratozoospermia to normozoospermia and the partner conceived within 2 cycles. The female experienced a safe and healthy antenatal phase and the couple was blessed with a baby boy.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"101190"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A traditional Cameroonian spice, Syzygium guineense curtails leukemia tumor growth through G2-M cell cycle arrest and predicted NLRP3 inflammasome pathway","authors":"Francine Tankeu Nzufo ,&nbsp;Constant Anatole Pieme ,&nbsp;Rajesh Kumar Meher ,&nbsp;Jean-Bosco Jouda ,&nbsp;Ninon Geornest Eudes Ronauld Etsassala ,&nbsp;Trupti Pradhan ,&nbsp;K. Nirmal Kumar ,&nbsp;Subrata Sen ,&nbsp;Madan Barkume ,&nbsp;Satyanshu Kumar ,&nbsp;Showkat Ahmad Mir ,&nbsp;Jyoti Kode","doi":"10.1016/j.jaim.2025.101202","DOIUrl":"10.1016/j.jaim.2025.101202","url":null,"abstract":"<div><h3>Background</h3><div><em>S. guineense</em> DC. var. <em>macrocarpum</em> (Engl.) F. White<em>.</em> plant has been a traditional Cameroonian spice used as medicine to treat several health conditions such as liver cirrhosis, vaginal infections, and cancer.</div></div><div><h3>Objective</h3><div>This study aims to investigate the anti-cancer effects of <em>Syzygium guineense</em> plant parts on leukemia preclinical models.</div></div><div><h3>Material and methods</h3><div>Crude extracts and fractions of <em>S. guineense</em> were tested to inhibit the proliferation of human leukemia cells and reduce tumor volume in leukemia xenograft KG1 in immunodeficient mice. Further active fractions were evaluated for the mechanism of action using cell cycle analysis. Inflammasome markers, key targets of chronic inflammation, were screened from phytoconstituents obtained by LC-MS analysis. Of these, putative compounds having potential anticancer efficacy were assessed for kinetic binding with Molecular docking using PyRx-Python Prescription 0.8, and molecular dynamics simulations were performed by GROMACS 22.04.</div></div><div><h3>Results</h3><div>Bark extract B₂ and leaf fractions L₄/L₅ exhibited significant (<em>P</em> &lt; 0.001) anticancer activity against leukemia cells in a dose-dependent manner. Mechanistically, in L₄/L₅ arrested HL-60 cells at G2/M phase (population increased to &gt;25 % at drug concentration up to 80 μg/ml compared to 8.8 % in control cells), while B₂ caused S phase arrest (population increased to 56.2 % at drug concentration up to 100 μg/ml compared to 45.8 % in control) in HL60 cells. L₄/L₅ treatment led to apoptosis induction in these cells. B₂ (<em>P=0.035)</em> and L₄ (<em>P=0.096)</em> significantly reduced the tumor xenograft KG1 in the animal model. HRMS allowed the identification of Betulinic Acid/Oleanolic Acid in L₄. Computational prediction and GROMACS simulations of these compounds revealed stable binding patterns between the component and target proteins NLRP3 and NEK-7 over 100 ns.</div></div><div><h3>Conclusion</h3><div>Our study has provided interesting leads that Cameroonian spice <em>S. guineense</em> fractions/extract exhibited anti-leukemia activity, which could be mediated by inhibiting the innate immune inflammasome pathway. The study emphasizes the importance of <em>S. guineense</em> plant parts that have the potential to be developed for novel targeted therapeutics for leukemia.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101202"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ten-week yoga intervention on problematic smartphone usage in university students: A randomized controlled trial","authors":"Vatsala Thapliyal,&nbsp;Jairam Kushwaha,&nbsp;Ghanshyam Singh Thakur","doi":"10.1016/j.jaim.2025.101199","DOIUrl":"10.1016/j.jaim.2025.101199","url":null,"abstract":"<div><h3>Background</h3><div>The rise in problematic smartphone use among university students underscores the potential of yoga, with its evidence-based ability to improve problematic behaviours at their core.</div></div><div><h3>Objective</h3><div>To determine whether a ten-week yoga intervention can reduce the symptoms of problematic smartphone usage in university students.</div></div><div><h3>Materials &amp; methods</h3><div>One hundred fifty participants aged between 18 and 23 years were randomly divided into a yoga (n=75) and a control group (n=75) with an allocation ratio of 1:1. The yoga group received yoga intervention for ten-weeks, whereas the control group carried out their normal daily routine. Each participant was assessed for the symptoms of problematic smartphone usage at baseline, post intervention and two months follow-up by using a standardized Problematic Use of Mobile Phone (PUMP) scale.</div></div><div><h3>Results</h3><div>Data were analyzed using SPSS 24.0. Repeated measure analyses of variance (RM-ANOVA) with baseline PUMP score used as a covariate have shown a significant reduction in overall problematic smartphone usage (<em>p</em>&lt;0.001; Bonferroni adjusted <em>post hoc</em> analyses) in the yoga group after ten-week of yoga intervention and at two months follow-up (<em>p</em>&lt;0.001).</div></div><div><h3>Conclusions</h3><div>The results suggest that regular practice of yoga may act as a useful approach to reduce the problematic smartphone usage and its associated symptoms in university students.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101199"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yogic gut aeration techniques to inhibit Helicobacter pylori-induced acid peptic diseases: A pilot randomized controlled trial","authors":"Rohini Dayma ,&nbsp;Rudra B. Bhandari ,&nbsp;Prakash Chintamani Malshe ,&nbsp;Tung Vir Singh Arya","doi":"10.1016/j.jaim.2025.101195","DOIUrl":"10.1016/j.jaim.2025.101195","url":null,"abstract":"<div><h3>Background</h3><div>The most common cause of acid-peptic diseases (APDs) is <em>Helicobacter Pylori</em> (<em>H. pylori)</em> infection<em>.</em> Conventionally, proton–pump inhibitors (PPIs) are used to manage hyperacidity and dyspepsia. PPIs’ persistent use can lead to bacterial resistance, side effects, poor quality of life (QoL), and increased economic burden. <em>H. pylori,</em> being microaerophilic, can be inhibited by gut aeration. Therefore, yogic gut aeration techniques (YGATs) may be a potential option to mitigate <em>H. pylori-</em>induced APDs and reduce medication doses and economic burden.</div></div><div><h3>Objective</h3><div>The study aimed to determine the effect of YGATs on gastrointestinal symptoms, stress, and quality of life (QoL) in patients with <em>H. pylori-</em>induced APDs.</div></div><div><h3>Method</h3><div>Patients with epigastric pain, gastric reflux, and stomach burning were screened and allowed to undergo an endoscopy followed by a rapid urease test (RUT) to confirm <em>H. pylori</em> infection. Thirty-four patients with positive RUT were randomly assigned into two groups. The yoga group (n = 16) received YGAT for two months and seven days in addition to PPI. The control group (n = 18) was provided only PPIs. Signs and symptoms of APD and its co-morbidities (stress and QoL) were measured by using the gastrointestinal symptom rating scale (GSRS), quality of life in reflux and dyspepsia (QOLRAD) questionnaire, and stress indicator questionnaire (SIQ).</div></div><div><h3>Results</h3><div>Split-plot ANOVA computed with Bonferroni adjusted post hoc analyses for intra and inter-group comparisons using the 24th version of IBM-SPSS showed a significant reduction in gastrointestinal symptoms (<em>p&lt;</em>0.001) and stress (<em>p&lt;</em>0.001) and improvement in QoL (<em>p&lt;</em>0.001) in the yoga group as compared to the control group.</div></div><div><h3>Conclusion</h3><div>YGATs may be a harmless and inexpensive alternative or add-on therapy to mitigate <em>H. pylori</em>-induced APDs and their psychological co-morbidities.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101195"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}