Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Coexisting pilonidal sinus and anal fistula: Successful management with minimal invasive Kshara Karma Technique and Ksharasutra therapy- A case report.","authors":"P Hemantha Kumar, Hetal Koriya","doi":"10.1016/j.jaim.2024.101082","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101082","url":null,"abstract":"<p><p>Pilonidal sinus (PNS) is a nest of hair which typically presents as pits, pus discharge, and an abscess at the natal cleft region. In rare conditions where pilonidal abscess is not drained properly, it progresses posteriorly and reaches anal canal, eventually coexisting with anal fistula. Both are associated with a high recurrence rate despite surgical management. A 27 year old female patient presented with complaints of non-healing wound in the natal cleft region and pus discharge from wound for 2 months with a past surgical history for PNS. On local examination, a wound was seen at the natal cleft, secondary pit 3cm away with scar mark of the previous operation, and a digital rectal examination (DRE) revealed an internal opening at 6 o'clock position that was communicating with the previously operated PNS wound. The patient was diagnosed as a case of coexisting anal fistula and recurrent PNS. Patient was managed under spinal anaesthesia with interception of fistulous tract using Ksharasutra (Medicated alkaline thread), followed by Minimal Invasive Kshara Karma Technique (MIKKT) for PNS. Ksharasutra was sloughed out after the fifth week, and complete wound healing of PNS was achieved in six weeks. By interception of the fistulous tract, the length of the tract was reduced, which facilitated early wound healing and minimal scar mark formation. MIKKT also prevented bigger excision and wound formation, eventually reducing complete healing duration, and Kshara(a medicated alkali) applied caused chemical cauterization and hence prevented recurrence of pilonidal sinus.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"101082"},"PeriodicalIF":1.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terminalia catappa aqueous extract reduces hyperglycaemia and oxidative stress in diabetic-hypercholesterolemic rats.","authors":"Ojaskumar D Agrawal, Yogesh A Kulkarni","doi":"10.1016/j.jaim.2024.101025","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101025","url":null,"abstract":"<p><strong>Background: </strong>Terminalia catappa is an important medicinal plant. Plants from the genus Terminalia have been reported for antidiabetic effects.</p><p><strong>Objective: </strong>To study effect of Terminalia catappa leaves aqueous extract in type 2 diabetic rats.</p><p><strong>Materials and methods: </strong>High-fat diet (HFD) and a low dose of streptozotocin (35 mg/kg, i.p.) were used for inducing type 2 diabetes in rats; streptozotocin was injected after two weeks of dietary modification with HFD. HFD was continued throughout the study. Doses of 500 and 1000 mg/kg of aqueous extract of Terminalia catappa were used as a treatment for six weeks. At the end of the study, biochemical and oxidative stress parameters were estimated. Histopathology and immunohistochemistry of pancreatic tissue were performed.</p><p><strong>Results: </strong>Significant decrease (p < 0.01, p < 0.001) was observed in glucose levels of diabetic animals treated with T. catappa extract at both dose levels when compared with diabetic control group. Treatment with aqueous extract reduced cholesterol levels significantly (p < 0.05). After receiving 1000 mg/kg of extract, the triglyceride level was significantly lowered (p < 0.01) in the diabetic rats. Extract treatment enhanced the insulin sensitivity index (ISI), while insulin levels and HOMA-IR were markedly reduced. Treatment with 1000 mg/kg of extract significantly enhanced the levels of GSH and catalase. Histopathological analysis of the pancreas showed that damage caused by hyperglycemia was prevented in the extract-treated groups. Pancreatic tissue showed an increased expression of SIRT1 in extract-treated animals.</p><p><strong>Conclusion: </strong>The current study's findings prove that the extract has remarkable antidiabetic effects.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"101025"},"PeriodicalIF":1.7,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory activity and selective inhibition of iNOS gene expression by a polyherbal formulation.","authors":"Boyagoda Vidanelage Loshini Ravima Ranaweera, Daniya Edward, Jayamini Chathurika Harasgama, Ajita Mahendra Abeysekera, Ovitigala Vithanage Don Sisira Jagathpriya Weerasena, Shiroma Mangalika Handunnetti","doi":"10.1016/j.jaim.2024.101049","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101049","url":null,"abstract":"<p><strong>Background: </strong>Link Samahan® (LS), a product of Link Natural Products (Pvt) Limited, Sri Lanka contains extracts of 14 medicinal plants. It is used as a prophylactic against cold and cold related symptoms. It has immunomodulatory activity, specifically enhancing the humoral immune response.</p><p><strong>Objective: </strong>To investigate the anti-inflammatory activity (AIA) of LS and related mechanisms.</p><p><strong>Materials and methods: </strong>In vivo AIA was assessed by the inhibition of carrageenan-induced rat paw-edema. Mechanisms of AIA were assessed in vitro by the inhibition of reactive oxygen species (ROS) and reactive nitrogen species (RNS) production and expression of inducible nitric oxide synthase (iNOS) gene using rat peritoneal cells.</p><p><strong>Results: </strong>LS showed an increasing inhibition in rat paw-edema up to 5 h compared to the biphasic pattern exhibited by the reference drug, Indomethacin. Inhibition by LS at the 1^st and 3^rd-5^th hours (44.7% and 73.0-74.6%) was comparable to indomethacin (47.4% and 83.6-76.5%; p > 0.05) whereas at the 2^nd hour, LS exhibited a significantly higher inhibition compared to indomethacin (66.7% vs 28.6%; p < 0.05). LS treatment significantly inhibited the ROS (superoxide; 47.2 ± 0.86%; p < 0.05) and RNS (nitrite; 54.0 ± 0.40%; p < 0.05) production in rat peritoneal cells. Further, specific inhibition of iNOS gene expression in rat peritoneal cells resulted in a significant reduction in RNS production whereas LS had lesser or no inhibitory effect on endothelial NOS and neuronal NOS gene expression.</p><p><strong>Conclusion: </strong>LS has potent anti-inflammatory activity and selective inhibition of iNOS activity. AIA of LS shown here supports its use as a prophylactic against cold and cold related symptoms.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"101049"},"PeriodicalIF":1.7,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentilla fulgens root extract rich in polyphenols ameliorate diabetic foot ulcers in wistar rats via regulating oxidative stress and connective tissue markers.","authors":"Suman Kumar, Yogesh P Nikam, Shatabdi Ghose, Susankar Kushari, Shailendra S Gurav, Satyendra K Prasad, Debasish Borbora, Damiki Laloo","doi":"10.1016/j.jaim.2024.101075","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101075","url":null,"abstract":"<p><strong>Background: </strong>Potentilla fulgens (Wall.) ex Hook. (Rosaceae), commonly known as 'Bajradanti' is native to the lower Himalayan regions inclusive of the North-East India. Traditionally, the plant is used to treat chronic ailments like diabetes and diverse wounds, including gastric and mouth ulcers, and injuries from tiger bites.</p><p><strong>Objective: </strong>This study aims to assess the efficacy of P. fulgens root extract rich in polyphenolics in healing diabetic foot ulcer (DFU) in rats.</p><p><strong>Methods: </strong>DFU was induced in streptozotocin-nicotinamide diabetic rat feet by open excision wound model. Rats were divided into eight groups (n = 6/group): normal, negative control, plain gel (placebo) control, 1% silver sulfadiazine, and P. fulgens treated with topical ethyl acetate (EAPF, 5% and 10%) and methanol extract (MEPF, 5% and 10%). The morphological, histological and various biochemical parameters associated with the wound healing process such as connective tissue repair and oxidative stress biomarkers were evaluated.</p><p><strong>Results: </strong>Topical application of EAPF 10% and MEPF 10% over 21 days significantly (p < 0.05) reduced ulcer area in DFU rats compared to negative control. Furthermore, the extracts treated group notably (p < 0.05) increased levels of connective tissue biomarkers (total protein, hydroxyproline, hexosamine, and hexuronic acid) and antioxidant components (SOD and GSH), while significantly (p < 0.05) decreasing levels of lipid peroxidation (LPO) in foot tissue homogenate. Histological analysis of rats treated with the extracts revealed significant evidence of tissue repair, characterised by enhanced epithelial and collagen formation, along with decreased polymorphonuclear infiltration and edema.</p><p><strong>Conclusion: </strong>In summary, treatment with EAPF 10% significantly improved foot ulcers by modulating oxidative stress and connective tissue biomarkers in DFU animals.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"101075"},"PeriodicalIF":1.7,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Chronic Plaque Psoriasis through Panchkarma: A case report.","authors":"Rohan Agalcha, Sarvesh Kumar Singh, Kshipra Rajoria","doi":"10.1016/j.jaim.2024.101072","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101072","url":null,"abstract":"<p><p>Psoriasis is a chronic systemic inflammatory skin disorder prevailing in 2%-3% individuals worldwide. Yet no permanent management has been established. Metabolic burdens and comorbidities have been found to be associated with Psoriasis, which make it more critical. The classical management of the disease in Ayurveda includes Vamana Karma (therapeutic emesis) and Virechana Karma (therapeutic purgation). This is a distinct case where a 52-year-old patient, suffering from Chronic Plaque Psoriasis (CPP), unfit for Vamana Karma was treated by VirechanaKarma only. The patient had suffered from Psoriasis since last 14 years and was present with symptoms of scaly lesions and intense itching. The patient was admitted in the IPD and planned for Virechana Karma. After Shodhana, Rasamanikya-125 mg, Vidanga Choorna 2 gm, Kaishora Guggulu-1000 mg, Kamdudha Rasa 250 mg, Khadirarishta-20 ml, and Punarnavadi Kwatha 40 ml, twice a day was advised with daily 3 times local application of Bruhad Marichyadi Taila as regular medication. The assessment was done by Psoriasis Area Severity Index (PASI) score, Dermatology Life Quality Index (DLQI) score and Numerical Rating Scale (NRS) for itching. The initial PASI, DLQI and NRS scores were 20.6, 18, and 8 respectively which was evaluated to be, 5.8, 4 and 2 respectively in the latest follow-up. This case study demonstrates that Virechana alone may also manage CPP.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"101072"},"PeriodicalIF":1.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic management of recurrent lumbar pain, disability, and leg pain after posterior decompression with transforaminal lumbar interbody fusion in prolapsed intervertebral disc: A case report.","authors":"Satyajit Pandurang Kulkarni, Pallavi Satyajit Kulkarni","doi":"10.1016/j.jaim.2024.101071","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101071","url":null,"abstract":"<p><p>Prolapsed intervertebral disc (PIVD) can lead to debilitating pain and functional limitations. While surgical interventions like Transforaminal Lumbar Interbody Fusion (TLIF) are often employed, recurrence of symptoms is not uncommon. This case report presents the successful Ayurvedic management of a 45-year-old female who developed recurrent lumbar radiculopathy six months after TLIF for PIVD. The patient presented with severe lumbar pain, disability, and bilateral leg discomfort. Diagnosed with \"Prushthagraha\" according to Ayurvedic principles, she underwent a 43-day treatment regimen. This included Ayurvedic medications and an initial eight-day course of Sarvanga Abhyanga-Mardana (therapeutic massage) and Swedana (sudation therapy). Post-treatment, the patient demonstrated significant clinical improvement, evidenced by a substantial reduction in Oswestry Disability Index (ODI) and Visual Analogue Scale (VAS) scores for both lumbar and leg pain. Furthermore, her walking distance increased from 80 m to 1000 m. This case highlights the potential of Ayurvedic interventions as a complementary approach for managing recurrent lumbar radiculopathy following surgical intervention for PIVD. However, further research with larger sample sizes and controlled study designs is warranted to validate these findings.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"101071"},"PeriodicalIF":1.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quo vadis, Ayurveda?","authors":"R S Rajan","doi":"10.1016/j.jaim.2024.101042","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101042","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"101042"},"PeriodicalIF":1.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charak Samhita Online Edition- A step towards globalization of Ayurveda.","authors":"Yogesh S Deole, Gopal Basisht","doi":"10.1016/j.jaim.2024.101058","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101058","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"101058"},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potency of ethyl acetate fraction of cempedak (Artocarpus champeden) leaves in attenuating the nephrotoxic effect in gentamicin-piroxicam-induced rat models.","authors":"Fitrya, Elfita, Syafrina Lamin, Fima Amalia Ashfa, Rennie Puspa Novita, Annisa Amriani","doi":"10.1016/j.jaim.2024.101040","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101040","url":null,"abstract":"<p><strong>Background: </strong>Nephrotoxicity is a condition characterized by a decline in kidney function due to the toxic effects of medications and substances, such as the nephrotoxic antibiotic gentamicin. Artocarpus champeden is a traditional medicinal plant that is commonly found in Indonesia.</p><p><strong>Objective: </strong>This study aims to evaluate the potential of the ethyl acetate fraction of Artocarpus champeden leaves (FEC) in improving kidney function in an animal model of nephrotoxicity induced by gentamicin and piroxicam.</p><p><strong>Materials and methods: </strong>Three groups of animals were treated with FEC at dosages of 125, 250, and 500 mg/kg BW orally for four weeks following induction with 100 mg/kg gentamicin (Gen) intraperitoneally and 3.6 mg/kg piroxicam (Prx) orally. The nephroprotective effect of FEC was compared with the NaCMC (5%), ketosteril (55 mg/kg), and untreated groups as the normal, positive, and negative controls, respectively. The kidney biochemical examinations and histopathological analysis were conducted on the last day.</p><p><strong>Results: </strong>Compared to the negative control group, FEC-treated animals showed significant improvement in kidney function, correlating with increasing doses. The test group also exhibited increased creatinine clearance and improved cell structure, comparable to samples treated with ketosteril. The nephroprotective effect of FEC is likely attributed to its flavonoid content, acting through antioxidant and anti-inflammatory mechanisms.</p><p><strong>Conclusion: </strong>The ethyl acetate fraction of A. champeden leaves demonstrated nephroprotective activity and has potential as a therapeutic agent for kidney damage and hypertension from natural sources.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"101040"},"PeriodicalIF":1.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Shirodhara and Abhyanga on serum cortisol in Anxiety - A case report.","authors":"Ashu Sharma, Megha Sugandh, Atul Bhardwaj, Arun Gupta","doi":"10.1016/j.jaim.2024.100948","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.100948","url":null,"abstract":"<p><p>Chittodvega, classified as a Mano-Vikara (psychological disorder) in Ayurveda, can be correlated with general anxiety disorder. The disturbance of Vata Dosha plays a critical role in its manifestation. Ayurvedic treatments such as Abhyanga (oleation) and Shirodhara (dripping of medicated oil or other suitable liquid on forehead) are known to pacify Vata. Abhyanga helps to stabilize the body, while Shirodhara enhances concentration, promoting mental stability. Both procedures synergistically balance VataDosha, addressing the physiological and psychological aspects of Chittodvega.A 50-year-old male patient presented with complaints of anxiety at Ch. Brahm Prakash Ayurveda Charak Sansthan, New Delhi. He underwent a 14-day treatment regimen, including 7 days of hospitalization and 7 days of follow-up. The treatment involved Abhyanga(Oleation) with Til Taila (sesame oil) and Shirodhara with Dashmool Siddha Ksheer (herbal milk decoction), aimed at assessing their impact on serum cortisol levels. Both, morning and evening cortisol level of this patient was within the normal range before and after the treatment. This study was done only to check the effectiveness of Abhyanga and Shirodhara on serum cortisol level. Observable changes were found in serum cortisol along with a reduction in the patient's anxiety symptoms, demonstrating the efficacy of these Ayurvedic interventions in managing Chittodvega.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 1","pages":"100948"},"PeriodicalIF":1.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}