Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Swarna Bhasma reduces the blood concentration of tumor-specific signatures and protects from hepatocellular damages in Ehrlich ascites mice model","authors":"Namrata Joshi ,&nbsp;Pankaj Kumar ,&nbsp;Shiwakshi Sharma ,&nbsp;Remya Jayakumar ,&nbsp;Anand Mishra ,&nbsp;V. Harsha ,&nbsp;Manoj Kumar Dash","doi":"10.1016/j.jaim.2025.101152","DOIUrl":"10.1016/j.jaim.2025.101152","url":null,"abstract":"<div><h3><strong>Background</strong></h3><div>The paradigm shift with alarmingly high rate of global cancer incidences encourages the application of incinerated gold Nano powder, Swarna Bhasma (SB) due to its exceptional potency, affordability, and minimal toxic effects. Previous experimental investigations were unable to provide a biochemical understanding of the anti-carcinogenic properties of SB.</div></div><div><h3><strong>Objective</strong></h3><div>To evaluate the tumour related markers in blood and possible alteration in hepatic parameters due to SB.</div></div><div><h3><strong>Methods</strong></h3><div>EAC (Ehrlich’s Ascites Carcinoma) induced tumour was generated in the female Swiss albino mice divided into 6 groups, namely, Vehicle Control (VC), Disease Control (DC), Standard Control (SC), and Treatment Groups with escalating doses (1.95, 3.9, and 7.8 mg/kg body weight) of SB. Blood serum quantified was measured for the levels of CEA (Carcinoembryonic antigen), TNF-α (Tumour Necrosis Factoralpha), IL-6 (Interleukin-6), ALT (Alanine transaminase), and AST (Aspartate aminotransferase). Changes in daily food consumption, body weight, and tumour volume (with Vernier caliper) were coherently studied and analysed. The data was analysed using One-Way ANOVA and Tukey's Honest Significance Test.</div></div><div><h3><strong>Result</strong></h3><div>SB demonstrated effective reduction of CEA levels at higher doses, and TNF-α levels at medium doses. Both moderate and high doses exhibited a noteworthy, dosedependent decrease in IL-6 levels. Furthermore, SB led to a dose-dependent reduction in the AST/ALT ratio. A significant reduction in tumour volume were reported in both the moderate and high doses of SB along with marked improvement in anorexia. The higher doses of SB exhibited the serum validated results in the hepatic, renal and the splenic tissues.</div></div><div><h3><strong>Conclusion</strong></h3><div>The anti-carcinogenic activity of SB appeared to be dose-dependent. The finding also underscored the hepato-protective capability of SB in lower dose by alleviating cancer-related liver damage</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101152"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Ayurvedic intervention for pseudomyxoma peritonei - A case report","authors":"Divya Sukumar,&nbsp;T. Sreekumar,&nbsp;P.V. Smitha Mohan,&nbsp;K. Shaji,&nbsp;A. Athulya","doi":"10.1016/j.jaim.2025.101166","DOIUrl":"10.1016/j.jaim.2025.101166","url":null,"abstract":"<div><div>Cancer is the deadliest disease in the world and cancer treatment remains as a challenge among all systems of medicine. Pseudomyxoma peritonei is one of the rarest malignancies, devoid of any promising management strategies. Ayurvedic perspective of diagnosis and reports on treatment strategies for such malignant conditions are highly limited. In this study, a male patient with pseudomyxoma peritonei, presented with breathlessness, abdominal distension, inguinal hernia and swelling of both legs with oozing. CT and biopsy reports diagnosed the disease as Pseudomyxoma Peritonei. He was provided with ayurvedic treatment for improving Quality of Life. <em>Paniya kshara</em> and <em>Bhallathaka vati</em> were the principal contents of the medication given. Other medications are <em>Punarnavadi kashaya, chirivilwadi kashaya</em>, Tab Neem, Tab <em>Haridra,</em> Cap <em>Rasasindoor</em> and Cap <em>Poornachandrodaya ras</em><em>a</em><em>.</em> After 90 days of treatment, patient got relief from breathlessness, leg swelling and oozing. The abdominal circumference also reduced remarkably from 108cm to 78cm, and the Quality of Life also improved. The treatment principle adopted was based on the concepts of <em>udara, arbuda</em> and <em>sopha</em>. Cautious combination of concepts from Ayurveda can provide effective treatment strategies to treat rare diseases.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101166"},"PeriodicalIF":1.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panchakarma treatment for painful Post-Traumatic Trigeminal Neuropathy – A case report","authors":"Manoj Shamkuwar ,&nbsp;Kiran Nimbalkar ,&nbsp;Diwakar Mani Tripathi ,&nbsp;Bhavna Bhatia ,&nbsp;Manisha ,&nbsp;Rohit Pal","doi":"10.1016/j.jaim.2025.101168","DOIUrl":"10.1016/j.jaim.2025.101168","url":null,"abstract":"<div><div>Trigeminal Neuralgia (TN) is characterized by sudden, electric shock-like pain triggered by innocuous stimuli. Post-Traumatic Trigeminal Neuropathy (PTTN), a traumatic subset of TN, shares these features but also involves sensory abnormalities and psychological distress. Conventional treatments, including medications and surgical interventions, often provide limited relief and have their limitations. <em>Ayurveda</em> offers a more holistic, non-invasive alternative for long-term management. This case study details a 45-year-old male patient with right-sided facial pain persisting for eight months, unresponsive to conventional medications. Baseline pain intensity was six out of ten on the Numerical Rating Scale (NRS). The interventions comprised <em>Virechana</em> (therapeutic purgation)<em>, Ksheera-bashpa Swedana</em> (therapeutic steam of medicated milk), <em>Nasya</em> (medication through nasal route)<em>, Shirodhara</em> (therapeutic streaming over head)<em>,</em> and <em>Matra Basti</em> (a form of unctuous enema), followed by a seven-month course of medications. During the course of treatment, pain intensity gradually reduced from six to one on the NRS, accompanied by significant improvements in emotional well-being, sleep, and overall quality of life. Follow-up assessments confirmed sustained benefits, including a decreased dependence on conventional medication. This case highlights the potential of <em>Ayurveda</em> in PTTN management. More case reports and series of this kind are desirable for a better insight into this management approach.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101168"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on Yoga for stress management: Bibliometric trends from 2000 to 2024","authors":"Juhi Kumawat,&nbsp;Kashinath G. Metri","doi":"10.1016/j.jaim.2025.101163","DOIUrl":"10.1016/j.jaim.2025.101163","url":null,"abstract":"<div><h3>Background</h3><div>Yoga has emerged as a widely recognized intervention for managing stress, with growing interest in its effectiveness across various populations. Despite expanding research, there remains a need for comprehensive analysis of trends within the literature to guide future studies and clinical applications.</div></div><div><h3>Objective</h3><div>This study aimed to analyze bibliometric trends in research on yoga for stress management, providing insights into publication patterns, key contributors, and evolving research directions in this field.</div></div><div><h3>Methods</h3><div>The experimental studies related application of yoga for stress management were searched from 2000 to 2024 on Scopus database. The search criteria were refined to include publications on yoga related to stress, with a focus exclusively on articles published in English. Quantitative data analysis was conducted using bibliometric tools, with visualizations created using VOSviewer.</div></div><div><h3>Results</h3><div>The analysis of 1025 articles revealed a significant increase in publications over 24 years, especially in the past four years. The International Journal of Yoga Therapy and the Journal of Alternative and Complementary Medicine were leading journals in this field. The United States and India were identified as primary contributors, with Khalsa SBS and Nagendra HR being the most prolific authors. Randomized controlled trials, meta-analyses, and systematic reviews emerged as predominant study types.</div></div><div><h3>Conclusion</h3><div>This comprehensive bibliometric analysis highlights the growth of yoga and stress management research, emphasizing randomized controlled trials and evidence-based practices. Future studies should explore yoga’s impact on diverse populations by age, occupation, and culture to clarify its universal applicability, advancing research and clinical applications.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101163"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of Medhya Rasayana, Bacopa monnieri, and Centella asiatica in enhancing memory and IQ of 8–10 year-old healthy boys: A prakriti-based double-blind, randomized controlled trial","authors":"Jitesh Verma ,&nbsp;Renu Rathi ,&nbsp;Anamika ,&nbsp;Bharat Rathi ,&nbsp;Vidya Bhushan Pandey","doi":"10.1016/j.jaim.2025.101164","DOIUrl":"10.1016/j.jaim.2025.101164","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive problems like learning difficulties, memory problems, intellectual disability, and ADHD are highly associated with school absenteeism and high dropout rates. The novel approach to improving memory and learning in these children is using nootropic herbs known as <em>Medhya Rasayana</em> (intellect enhancer) in Ayurveda. <em>Brahmi</em> (<em>Bacopa monnieri</em> L. Pannel), one of the Medhya Rasayana, has proven to be useful through extensive research. Still, the other <em>Medhya Rasayana</em> requires thorough research based on the Ayurvedic principle of <em>Prakriti</em> (constitution) to utilize their optimum therapeutic effect.</div></div><div><h3>Objectives</h3><div>The main objective of this study was to evaluate the comparative efficacy of <em>Mandookaparni</em> in enhancing the memory of healthy boys with dominant <em>Prakriti</em>.</div></div><div><h3>Material &amp; methods</h3><div>The present study was a double-blind, randomized study to evaluate the comparative efficacy of <em>Brahmi</em> (<em>Bacopa monnieri</em> L. Pannel) and <em>Mandookaparni</em> (<em>Centella asiatica</em> L. Urban) in enhancing the memory of 8-10-year-old healthy boys with dominant <em>Prakriti</em>. After obtaining informed consent from parents and assent from the participants, the eligible study participants were randomized to either the <em>Mandookaparni</em> or the <em>Brahmi</em> group. The participants were assessed at baseline and end of the treatment (91st day) for efficacy measures, which included total memory score and various domains of memory assessed by the Post Graduate Institute- Children's Memory Scale (PGI-CMS) and Intelligence Quotient.</div></div><div><h3>Results</h3><div>On analysis of 180 participants, the <em>Brahmi</em> group showed highly significant results in the total memory score, 9 out of 10 subsets of PGI-CMS, and IQ with p &lt; 0.001. The <em>Mandookaparni</em> group showed highly significant results in 8 subsets of PGI-CMS, the total memory score, and IQ with p &lt; 0.001. <em>Brahmi</em> increased the mean total memory score by 9.28 %, while a 13.45 % rise was observed with <em>Mandookaparni</em>. Significant differences were observed chiefly in <em>Pitta Prakriti</em> on Prakriti-wise analysis in the improvement of various memory domains between <em>Brahmi</em> and <em>Mandookaparni</em>.</div></div><div><h3>Conclusions</h3><div><em>Mandookaparni</em> has clinically equivalent efficacy to <em>Brahmi</em> in enhancing memory. <em>Mandookaparni</em> is better in improving the memory of <em>Pitta Prakriti</em> people while <em>Brahmi</em> is more effective in <em>Kapha</em> and <em>Vata Prakriti</em>. Both drugs are safe and effective in the pediatric population.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101164"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effect of cow urine on stem cell differentiation, senescence, oxidative stress and angiogenesis in chick yolk sac model","authors":"Avinash Kharat,&nbsp;Swapnali Sakhare,&nbsp;Avinash Sanap,&nbsp;Pranjali Potdar,&nbsp;Supriya Kheur,&nbsp;Ramesh Bhonde","doi":"10.1016/j.jaim.2025.101194","DOIUrl":"10.1016/j.jaim.2025.101194","url":null,"abstract":"<div><h3>Background</h3><div>Cow urine has been utilized in traditional Indian medicine for the treatment of various ailments such as wounds, oxidative stress, and the management of various metabolic disorders with limited toxicity. However, there is a scarcity of scientific evidence confirming its exact mode of action.</div></div><div><h3>Objectives</h3><div>The aim of the study is to examine the mode of action of cow urine, also known as \"Gomutra\", focusing on its effect on human dental pulp stem cells (DPSCs) and chick yolk sac membrane (YSM) models.</div></div><div><h3>Material and methods</h3><div>DPSCs were isolated and characterised using a flow analyser, and used to assess the cytotoxicity, osteogenic and chondrogenic differentiation potential, anti-aging activity, anti-oxidative nature. Angiogenic potential was evaluated by YSM model.</div></div><div><h3>Results</h3><div>DPSCs showed fibroblast-like morphology and expressed mesenhymal stem cell markers viz., CD73, CD90, and CD105, and lacked expression of CD34, CD45 and HLA-DR. Our findings indicated that cow urine showed no toxicity at 1, 2, 4, 5, 10, 20 and 25% concentrations and promoted osteogenic and chondrogenic differentiation of DPSCs compared to standard controls. Additionally, cow urine effectively reduced oxidative stress and delayed cellular senescence in DPSCs, suggesting its anti-aging potential. Further, the study evidenced cow urine's angiogenic activity through YSM model.</div></div><div><h3>Conclusion</h3><div>This study provides substantial evidence for the non-toxic nature of cow urine. Our data demonstrates bone and cartilage regeneration, ant-aging, angiogenic and anti-oxidative nature of cow urine indicating its therapeutic value.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101194"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Mamsyadi Ghana capsule and Saraswatarista in the management of Insomnia Disorder - A Randomized Controlled Clinical Trial","authors":"M. Manasa ,&nbsp;Aswini Padmashali ,&nbsp;Basavaraj R. Tubaki ,&nbsp;Manisha","doi":"10.1016/j.jaim.2025.101160","DOIUrl":"10.1016/j.jaim.2025.101160","url":null,"abstract":"<div><h3>Background</h3><div>One of the prevalent sleep disorders is insomnia disorder. Current pharmacotherapy have limitations like dependence, tolerance and withdrawal effects. Ayurveda drugs remains to be explored.</div></div><div><h3>Objectives</h3><div>Can Ayurveda intervention (<em>Mamsyadi Ghana</em> Capsule and <em>Saraswatharista</em>) play a role in Insomnia disorder.</div></div><div><h3>Material and Methods</h3><div>50 patients meeting the diagnostic criteria of Insomnia Disorder (DSM 5), age group 20–70 years, either sex participated in the study. They were randomly divided and Ayurveda group received <em>Mamsyadi Ghana</em> Capsule 500 mg, <em>Saraswatharista</em> 10 ml, with equal quantity of water after food, both thrice a day for 30 days. Zolpidem group received tablet Zolpidem 10 mg once a day at bed time. Evaluations were done through Insomnia severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness scale (ESS), Sleep diary parameters, Depression Anxiety and Stress Scale (DASS), Quality of Life – SF 36 Questionnaire and UKU side effect rating scale. Clinical assessments were at baseline, 15th and 30th day.</div></div><div><h3>Results</h3><div>The study showed that Ayurveda intervention produced significant improvement and was comparable to Zolpidem. Both interventions were comparable in ISI, PSQI, ESS, DASS scale, sleep diary parameters and most of the components of SF-36. Role of limitations due to emotional problems component showed better improvement in Ayurveda group (p = 0.01). Within group analysis showed improvement in both the groups. Five patients had adverse effects with Zolpidem and nil with ayurveda group.</div></div><div><h3>Conclusions</h3><div>The study showed that effect of Ayurveda interventions (<em>Mamsyadi Ghana</em> Capsule and <em>Saraswatharista</em>) is comparable to zolpidem in Insomnia Disorder. Ayurveda intervention had better improvement on quality of life and had good safety profile.</div></div><div><h3>Ctri registration number</h3><div>CTRI/2021/12/038809.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101160"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective potential of dombeya wallichii ameliorates Parkinson's activity in paraquat-induced Rat's model via modulation of neuro-inflammatory cytokines","authors":"Hafsa Tariq ,&nbsp;Khizra Ishfaq ,&nbsp;Talha Chauhdari ,&nbsp;Fatima Sarwar ,&nbsp;Fazeela Ismail","doi":"10.1016/j.jaim.2025.101162","DOIUrl":"10.1016/j.jaim.2025.101162","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) is a prevalent age-related neurodegenerative condition that develops gradually and is observed in around 1 % of the elderly population. Lately, there has been an increasing curiosity about the possibilities of phyto-components for the treatment of PD due to their rich array of active compounds, notably antioxidants and anti-inflammatory agents.</div></div><div><h3>Objective</h3><div>Our objective was to assess the impact of an ethanolic extract from <em>Dombeya wallichii</em>, which has antioxidant properties, on the Parkinsonian rat's model.</div></div><div><h3>Material and methods</h3><div>Rats received 10 mg/kg paraquat to assess its antiparkinsonian effects. They were treated with ethanolic extract of <em>Dombeya wallichii</em> (200, 400, 600 mg/kg) for 21 days, 1 h after paraquat. Behavioral aspects were evaluated before sacrifice. On day 22, rats were euthanized, and their bodies examined for changes in antioxidant enzymes (superoxide dismutase, glutathione, malondialdehyde, catalase), neurotransmitter levels (dopamine, noradrenaline, serotonin, acetylcholinesterase), mRNA expression and neuroinflammatory cytokines (Interleukin-1β, Tumor Necrosis Factor-α, nuclear factor kappa B, Interleukin-6).</div></div><div><h3>Results</h3><div>The ethanolic extract of <em>Dombeya wallichii</em> reduced paraquat-induced motor deficits in the rotarod, hole board, akinesia, and forelimb hanging tests. It also improved biochemical and neuroinflammatory markers by lowering oxidative stress and inflammatory cytokines, showing antioxidant and anti-inflammatory activities. q-RT-PCR revealed that <em>D. wallichii</em> downregulated α-synuclein, Interleukin-1β, nuclear factor kappa B, and Tumor Necrosis Factor-α, while mRNA expression indicated neuroprotection.</div></div><div><h3>Conclusion</h3><div>These findings suggest that <em>Dombeya wallichii</em> could be a viable candidate for Parkinson's disease treatment, owing to its antioxidant and anti-inflammatory properties.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101162"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-silico docking analysis of bioactive compounds sourced from Punica granatum peel extract: Approaching a precision solution for ovarian cancer","authors":"Swarupa Hatolkar ,&nbsp;Aishwarya Patil ,&nbsp;Hiramoni Lahkar ,&nbsp;Poulomi Chakraborty ,&nbsp;Bhagyashree Vinit Gokhale ,&nbsp;Aarti Shastri","doi":"10.1016/j.jaim.2025.101125","DOIUrl":"10.1016/j.jaim.2025.101125","url":null,"abstract":"<div><h3>Background</h3><div>The MAPK signalling pathways, particularly those involving EGFR and VEGFR, play a pivotal role in the initiation and progression of ovarian cancer. Inadequate regulation of these pathways may lead to uncontrolled cell proliferation, angiogenesis, and metastasis. Targeting mitogen-activated protein kinases (MAPKs), including the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR), has demonstrated significant potential in restraining cancer cell proliferation and angiogenesis, representing a promising avenue among various therapeutic strategies.</div></div><div><h3>Objectives</h3><div>This manuscript aims to investigate the possibility of Mashi a pomegranate peel extract for ovarian cancer treatment, specifically targeting MAPKs (EGFR and VEGFR). Pomegranate (Punica granatum) is a well-known fruit whose varied portions have been used in traditional medicine for ages.</div></div><div><h3>Materials and methods</h3><div>In silico docking of bioactive compounds extracted from the pomegranate peel extract was done using the Autodock 4.2.6 software. A total of 10 two-dimensional ligands were generated with Pubchem site. The targeted proteins VEGFR, EGFR, MAPK, and MAPK8 were docked with the ligands (Sphondin, Isorhamnetin, Lupinine, Ellagic acid, and Citric acid) which were bioactive ingredients identified from pomegranate peel extract.</div></div><div><h3>Results</h3><div>It was observed that the binding energy of protein MAPK 8, MAPK 14, and VGFR was higher to the ligand at ellagic acid at -8.25kcal/mol, -7.61kcal/mol, and - 5.85kcal/mol respectively. However, EGFR observed to bind with ligand Isorhamnetin at -7.48kcal/mol.</div></div><div><h3>Conclusion</h3><div>The MAPK signalling pathways, specifically involving EGFR and VEGFR, play a crucial role in the initiation and dissemination of ovarian cancer. Dysregulation of these pathways can lead to unrestrained cell proliferation, angiogenesis, and metastasis. Our study revealed favorable binding energy between targeted proteins and ligands. Consequently, we infer that proteins exhibiting robust binding energy with bioactive compounds from pomegranate peel extract may exert regulatory control over the signalling pathways. This implies that EGFR and VEGFR can modulate signals by binding to the bioactive compounds in pomegranate peel extract, thereby regulating the MAPK pathway and ultimately curtailing uncontrolled cell proliferation, angiogenesis, and tumor metastasis. supported by simulation studies results.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101125"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative effect of Inula racemosa Hook. F root extract against diethylnitrosamine induced hepatic damage in murine model","authors":"Smriti Jamwal ,&nbsp;Rakesh Kumar ,&nbsp;R.K. Asrani ,&nbsp;Ankita ,&nbsp;Abhishek Verma ,&nbsp;Ekta Bisht ,&nbsp;Shreya Katoch ,&nbsp;Vikram Patial ,&nbsp;Vinesh Sharma ,&nbsp;Adarsh Kumar ,&nbsp;R.D. Patil","doi":"10.1016/j.jaim.2025.101173","DOIUrl":"10.1016/j.jaim.2025.101173","url":null,"abstract":"<div><h3>Background</h3><div>Liver disease is one of the most serious health problems worldwide. In the present scenario, the available therapies for liver ailments are not very effective and systemic toxicity inhibits their long-term use. Several medicinal plants have demonstrated promising effects against liver damage. These plants can help to prevent liver injury, reduce inflammation, enhance liver detoxification, and support liver cell regeneration and one such medicinal plant is <em>Inula racemosa.</em> The bioactive constituents present in the root extract of <em>Inula racemosa</em> i.e. alantolactone and isoalantolactone are responsible for its hepatoprotective potential.</div></div><div><h3>Objectives</h3><div>The current study aimed to elucidate the preventive action of <em>Inula racemosa</em> root extract against chemically-induced liver damage using Diethylnitrosamine (DEN).</div></div><div><h3>Material and methods</h3><div>Sprague Dawley (SD) 42-male rats were used in a 10-week study to examine the hepatoprotective effects of 3 different dosages (100, 250, and 500 mg/kg body weight) of <em>Inula racemosa</em> root extract against DEN-induced liver damage. The investigation included gross pathology, histopathology, immunohistochemistry (TGF-β and NF- κB), ultrasonography, and serum biochemistry (ALT, AST, ALP, Total protein, Albumin, Creatinine, and BUN).</div></div><div><h3>Results</h3><div>The <em>in vivo</em> research establishes <em>Inula racemosa</em> root extract's hepatoprotective efficacy by ameliorating biochemical parameters, lipid peroxidation, gross and histopathological alterations, and reduced immunohistochemical expression of TGF-β and NF- κB. The greatest defense against chemically-induced liver damage was provided by the highest dosage of the extract i.e. 500 mg/kg body weight.</div></div><div><h3>Conclusions</h3><div>The results of this investigation showed that the <em>Inula racemosa</em> root extract showed hepatoprotective activity against DEN-induced liver damage in the rat model.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101173"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}