Journal of Ayurveda and Integrative Medicine最新文献

{"title":"A systematic review and meta-analysis focusing on the use of ayurvedic medicine in cerebral palsy.","authors":"A M O Rocha, C A Len, F H Santos, S B O Iglesias, J R Bissoto","doi":"10.1016/j.jaim.2024.101035","DOIUrl":"https://doi.org/10.1016/j.jaim.2024.101035","url":null,"abstract":"<p><p>Integrative practices have been incorporated into palliative care to provide holistic and multidimensional care for patients. This study aims to identify the scope of integrative practices, specifically whole medical systems, and demonstrate its safety and efficacy, specially in children with cerebral palsy. Key databases, including Embase, Cochrane, Medline/PubMed, Scopus, Google Scholar, Lilacs and Scielo were searched using specific terms. Only randomized and non-randomized clinical trials were included for meta-analysis purposes. Case-control, cohort, cross-sectional or retrospective observational studies were also included for the systematic review. Participants included children aged 0-18 years receiving palliative care for cerebral palsy and undergoing Ayurvedic Medicine practices. Descriptive analysis was conducted, including data such as year; author; design; sample size; intervention and comparison; outcomes and conclusion. Two interventional studies compared Ayurvedic practices with each other or with physiotherapy in children with cerebral palsy. The meta-analysis demonstrated an improvement in spasticity for children using Ayurvedic medicine. However, there were limitations in terms of heterogeneity in interventions, control groups, and assessed outcomes. Integrative practices, including Ayurvedic medicine have the potential to improve quality of life, manage disease symptoms and provide emotional support. However, more robust evidence is needed to support their widespread use. The use of Ayurvedic medicine showed evidence of improvement in spasticity for children with cerebral palsy. REGISTRATION NUMBER: Prospero CRD 42020198399.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classical ayurveda management of TCH (taxane, carboplatin, and herceptin) based chemotherapy induced peripheral neuropathy- A case report","authors":"","doi":"10.1016/j.jaim.2024.101044","DOIUrl":"10.1016/j.jaim.2024.101044","url":null,"abstract":"<div><p>Although empirical data on the influence of Ayurveda on Chemo/Radiotherapy-induced side effects are limited, its methodological framework, grounded in a 'systems thinking' perspective, enables the precise delineation of the pathogenic stage of these side effects. This, in turn, facilitates the development of a strategy to address the decline in the quality of life parameters commonly associated with cancer treatment. Ayurveda personalized approach to disease management typically involves providing customized diets, lifestyle adjustments, medications, and detoxification therapies that target the entire body.</p><p>We present a case involving a patient with numbness and pain in the right hand after undergoing chemotherapy who was referred to us by an oncologist for symptom management. This case report demonstrates the Ayurveda approach for establishing the etiology, pathogenesis, pathophysiology, and treatment of Chemotherapy-Induced Peripheral Neuropathy (CIPN) resulting from taxane-based chemotherapy. Following Ayurveda intervention, the patient exhibited significant improvements in symptoms and quality of life parameters.</p><p>This case report systematically illustrates the application of Ayurveda approach in CIPN management.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624001591/pdfft?md5=54366e63e4f13d6b195d6ea5fecbf6b7&pid=1-s2.0-S0975947624001591-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurinformatics Laboratory- A synergy platform for Ayurveda and technology","authors":"","doi":"10.1016/j.jaim.2024.101019","DOIUrl":"10.1016/j.jaim.2024.101019","url":null,"abstract":"<div><p>The Ayush sector has attained buoyant growth in the past decade as a science, public health, medicine, and industry. Artificial Intelligence, computational drug designing, and other combinatorial techniques could further accelerate the sector's growth. In this edition, we delve into the confluence of Ayurveda and technology, a theme that resonates profoundly in the contemporary healthcare and wellness landscape. The fusion of Ayurveda, an ancient system of medicine rooted in holistic well-being, with cutting-edge technology, is not just a paradigm shift but a necessary evolution in pursuing an integrated healthcare system where all systems have their defined, recognized, and respected contribution. Here, We are highlight one-such fusion initiative \"Ayurinformatics Laboratory\".</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624001347/pdfft?md5=66284fa327c82e9a05891c2fcff945d0&pid=1-s2.0-S0975947624001347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic management of systemic sclerosis - A case report","authors":"","doi":"10.1016/j.jaim.2024.100956","DOIUrl":"10.1016/j.jaim.2024.100956","url":null,"abstract":"<div><p>Scleroderma, an autoimmune connective tissue disorder, leads to skin and tissue thickening. In this autoimmune disease condition, the defense mechanism works against the body itself and mistakenly attacks normal cells. Ayurveda links it to <em>vatarakta</em>, initially affecting <em>tvak</em>, <em>rakta</em>, and <em>mamsa</em>. <em>Vata</em> is primarily involved, but as the disease progresses, all <em>doshas</em> and <em>dhatu</em> get involved.</p><p>A 45-year-old woman presented with skin hardening, skin depigmentation all over her body, limb stiffness, weakness, arthralgia, anorexia, constipation and burning in the chest region for the last three years.</p><p>She was diagnosed with diffuse systemic sclerosis (SSc) but as per Ayurveda we can correlate with <em>aamvata</em> and <em>vatarakta</em> based on her <em>lakshanas</em>(symptoms).</p><p>Ayurvedic treatment commenced with <em>vardhamana pippali</em>(<em>Piper longum</em>)<em>rasayan</em>, <em>svedana karma</em>, and <em>virechan karma</em>, followed by <em>basti</em>(enema) <em>chikitsa (pathyadi kvath niruh basti)</em> and oral ayurvedic medication viz., <em>Manjisthadi kvatha</em>, <em>kaishora guggulu</em>, <em>Jatamansi(Nardostachys Jatamansi) churna, mishreya(Foeniculum vulgare) arka, dashang churna</em> with water for local application and daily <em>shamanarth panchtikta ghrit.</em></p><p>After 8 weeks, depigmentation was reduced, new hair growth emerged, mild skin softening occured, chest burning, anorexia, sleeplessness was decreased and enhanced mental well-being.</p><p>The treatment aimed to balance vitiated doshas and dhatu while alleviating symptoms, and enhancing overall well-being, demonstrating the efficacy of the holistic approach in managing scleroderma through Ayurveda.</p><p>Auto-immune disorder, scleroderma, chronic complications, skin tightness, salt pepper depigmentation, sclerodactyly.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000718/pdfft?md5=da9d36f463e172d0440b1f4e0ad8b25e&pid=1-s2.0-S0975947624000718-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoprotective effect of flavonoid rich fraction of Sesbania grandiflora: Results of In vivo, in vitro, and molecular docking studies","authors":"","doi":"10.1016/j.jaim.2024.101036","DOIUrl":"10.1016/j.jaim.2024.101036","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Phytochemicals and their derivatives are promising target drugs for various ailments and have served as therapeutic agents for several decades. Using &lt;em&gt;in vivo&lt;/em&gt; and &lt;em&gt;in vitro&lt;/em&gt; models and molecular docking, this study investigated the pharmacological potential of a flavonoid-rich fraction of the ethanolic extract of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; (SG).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;p&gt;This research aimed to determine whether flavonoid-rich whole-plant extracts of SGs have any cytoprotective or &lt;em&gt;in vivo&lt;/em&gt; hepatoprotective effects. Additionally, the study was intended to elucidate the molecular connections between the discovered flavonoid flavonols and PPARα target proteins linked to liver problems, for which an in silico molecular docking investigation was performed.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;p&gt;To separate the flavonoid components, the entire &lt;em&gt;Sesbania grandiflora&lt;/em&gt; plant was first extracted using ethanol as a solvent by soxhlet extraction. The resulting ethanolic extract was then fractionated. The cytoprotective and hepatoprotective properties were evaluated via &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; experiments. SGOT, SGPT, triglyceride, bilirubin, and total protein levels were used to evaluate hepatotoxicity in animal models. &lt;em&gt;In vitro&lt;/em&gt; studies on Hepatocellular Carcinoma G2 (HepG2) cell lines have examined their cytotoxic effects and antioxidant activity. The most promising flavonoid-flavanol compounds were identified by conducting molecular docking studies against PPARα target protein (PDB ID: &lt;span&gt;&lt;span&gt;3VI8&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;) using MOE software.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;&lt;em&gt;In vivo&lt;/em&gt;, the serum levels of SGOT, SGPT, total triglyceride and total bilirubin were measured in experimental animals treated with the flavonoid-rich ethanolic extract of SG. Significant reductions in the levels of these hepatic injury markers were observed, indicating the hepatoprotective potential of the extract. Elevated levels of liver biomarkers in the untreated group indicated liver injury or dysfunction. The treated groups showed significant restoration of these biomarkers, suggesting the hepatoprotective potential of &lt;em&gt;SG&lt;/em&gt;. The IC&lt;sub&gt;50&lt;/sub&gt; value for the total flavonoid content of SG was 190.28 μg/ml, indicating its safety in inhibiting HepG2 cell growth. Flavonoid treatment decreased cell viability but did not affect antioxidant parameters in hepatocytes. In addition, SG restored the damaged hepatocyte architecture. Molecular docking studies revealed the binding affinities of flavonoids for PPARα. These findings suggest that a promising lead candidate for the development of therapeutic medicines against anti-TB drug-induced hepatotoxicity has been identified.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Our findings demonstrate the hepatoprotective potential of the flavonoid-rich fraction of &lt;em&gt;Sesbania grandiflora&lt;/em&gt; both &lt;em&gt;in vivo&lt;/em&gt; and &lt;em&gt;","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624001517/pdfft?md5=0f7fc8a45bc8f15450e3737f599c90e3&pid=1-s2.0-S0975947624001517-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural study on the uses of traditional herbal medicine to treat various women's health issues in Northeast India","authors":"","doi":"10.1016/j.jaim.2024.101024","DOIUrl":"10.1016/j.jaim.2024.101024","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;This cross-cultural study conducted in the diverse regions of Assam, Meghalaya, and Manipur sheds light on the common utilization of five specific medicinal plants among indigenous communities residing in these areas.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;The main focus of this study is to document and compare the traditional medicinal plant used and the knowledge and practices related to women's health issues in different cultures; to identify commonalities and differences in the use of medicinal plants across cultures and various medicinal plants used traditionally by the indigenous communities to treat women's health problems according to their indigenous name, scientific name.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;The study used a survey method and a pre-structured interview schedule through one-on-one interactive communication and field observation. The authors collected data from three different states, i.e., Assam (Karbi Anglong district &amp; Udalguri district), Meghalaya (East Khasi Hills district), and Manipur (Senapati district) by personally meeting and interacting with traditional herbal medicinal practitioners. For this study, 10 practitioners from each area of study were interviewed. During the data collection process, the vernacular name of the medicinal plant, methods of preparation, mode of application, and probable dosage were compiled and documented involving practitioners belonging to four different communities, i.e, Bodo, Karbi, Khasi, and Poumai Naga of the selected states.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 39 plant species were meticulously collected and documented across the Karbi Anglong district and Udalguri district in Assam, East Khasi Hills district in Meghalaya, and Senapati district in Manipur. Turmeric (&lt;em&gt;Curcuma longa&lt;/em&gt;), ginger (&lt;em&gt;Zingiber officinale&lt;/em&gt;), gooseberry (&lt;em&gt;Emblica officinalis&lt;/em&gt;), papaya (&lt;em&gt;Carica papaya&lt;/em&gt;), and passion fruit (&lt;em&gt;Passiflora edulis)&lt;/em&gt; have emerged as common medicinal resources within these communities. Poaceae, represented by 5 species, emerged as the dominant family among the collected plants, highlighting the diversity and significance of these botanical remedies. &lt;em&gt;Zingiber officinale&lt;/em&gt; Roscoe \" has the highest usage report of 18 with an RFC (Relative frequency citation) of 0.45.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;The study's findings reveal a rich repository of traditional herbal knowledge in the northeast regions of India. Notably, the indigenous communities of these regions use plant resources to cure a wide range of ailments. This study emphasizes the necessity of documenting, preserving, and transmitting traditional herbal medicinal knowledge for both cultural and practical reasons. It also provides vital insights into the importance of cross-cultural study in promoting different cultures, the richness of traditional medicinal knowledge by engaging with diverse cultures and demonstrates ","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624001396/pdfft?md5=0d1e78e724747eaf81fd946f8f26c940&pid=1-s2.0-S0975947624001396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of post-hysterectomy urinary incontinence with composite Ayurveda treatment – A case report","authors":"","doi":"10.1016/j.jaim.2024.100961","DOIUrl":"10.1016/j.jaim.2024.100961","url":null,"abstract":"<div><div>This is a case report of a patient who developed urinary incontinence after undergoing abdominal hysterectomy. This was successfully treated with Ayurvedic treatment procedures. A 63-year-old lady was suffering from urinary incontinence, which developed after hysterectomy. It did not subside even after undergoing trans vaginal taping. She was treated with Ayurvedic procedures and medicines for a period of 2 and a half months from 4^th of March 2016 to 26^th of May 2016. <em>Matrabasti</em> (medicated enema) and <em>Madhutailika</em> <em>basti</em> (enema treatment with honey and oil), along with other palliative medicines – <em>S</em><em>ukumara ghrita, Chandraprabha vati,</em> <em>S</em><em>hilajatu,</em> <em>M</em><em>ahakalyanaka kashaya,</em> <em>M</em><em>amsapachaka ghana vati and Mahatiktaka ghrita</em> were given to the patient. Urinary incontinence reduced to dribbling of urine after Matra basti and after the second course of <em>B</em><em>asti</em> (medicated enema), that is after one and half months, patient stopped using diapers and was relieved from incontinence. This case report summarises the effective management of urinary incontinence by adopting basti (enema) treatment along with other palliative ayurvedic medicine.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse pharmacology based clinical protocols for noninvasive integrative management of low grade cervical precancer lesions: Rationale and outcomes","authors":"","doi":"10.1016/j.jaim.2024.100966","DOIUrl":"10.1016/j.jaim.2024.100966","url":null,"abstract":"<div><p>Prevention is the most efficient and cost-effective method to combat cervical cancer for which High Risk Human Papilloma Virus (HR-HPV) infection is identified as the major causative factor. HPV vaccination is for primary prevention whereas surgical ablation of precancer is for secondary prevention after HPV infection has occurred. Screening of women for early detection of Squamous Intraepithelial Lesions (SILs) with Papanicolou smear (Pap smear) is a desirable pre-requisite. Surgical ablation which invites invasive procedures is not accessible nor affordable to the larger section of the population. We propose here a non-invasive integrative management approach for the early phase of cervical pre-cancer.</p><p>In tune with the reverse pharmacology approach, ‘experience-exploration- experimentation’, we have conducted five clinical studies related to Turmeric extracts for chemo-preventive activity and non-surgical feasibility. We were able to achieve arrest or regression in Low-grade SILs in all 41 women participating in these studies.</p><p>The unique features of this integrative management approach were i) Avoidance of surgery-associated trauma, cost and complications ii) Standard of care for associated genital infections iii) Feasibility when surgery was not accessible iv) Scope for repeating the noninvasive treatment.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000810/pdfft?md5=c852cad33b0666ba99e0056247e76456&pid=1-s2.0-S0975947624000810-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142135838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of congenitally fused cervical vertebrae with Ayurveda intervention - A case report","authors":"","doi":"10.1016/j.jaim.2024.100964","DOIUrl":"10.1016/j.jaim.2024.100964","url":null,"abstract":"<div><p>A 42-year-old male patient presented with complaints of vertigo, neck pain, swallowing difficulties, and difficulty in maintaining an upright posture. The patient took allopathic consultation for the complaints and was advised to undergo MDCT scan of brain, hematological and audiological evaluations. No abnormalities were detected in the investigations and he was given some medications for symptomatic management. As no relief was noted, the patient took an Ayurveda consultation. After clinical evaluation, the patient was advised to perform an X-ray of the cervical spine and was diagnosed with congenital block vertebrae at C3 – C4 vertebral bodies and posterior appendages with hypoplastic intervening disc space. He was advised to take Ekangveerarasa 250 mg BD before food with honey, Trayodashang guggulu 1 gm BD after food, Vishatinduka vati 250 mg BD after food, Aswagandha churna 3 gm BD after food with milk.The patient was also advised to do light massage and mild hot fomentation in the neck region twice a day with Mahavishagarbha oil. Remarkable relief was observed with all signs and symptoms including a reduction of score in the Neck Disability Index (NDI) within a very short duration of treatment. Considerable improvements were noted in the quality of life of the patient as confirmed by the WHO QOL BREF score. This case report shows that Ayurveda can offer safer and more effective symptomatic treatment for conditions like congenitally fused vertebrae.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000792/pdfft?md5=c0ad21ce9ab5d86ce9ddb5e176cdebce&pid=1-s2.0-S0975947624000792-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory single-arm open-label clinical study to evaluate the combined effect of Vamana and Sarasvata Churna in reducing excessive daytime sleepiness","authors":"","doi":"10.1016/j.jaim.2024.100960","DOIUrl":"10.1016/j.jaim.2024.100960","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Excessive Daytime Sleepiness (EDS) is inferred as persistent sleepiness and often a general lack of energy during the day even after apparently adequate or even prolonged nighttime sleep. The subjects may not be identifying excessive daytime sleepiness but may present as feeling tired, lack of energy etc. They may seem apparently healthy and without any other systemic illness. The prevalence was found to be as high as 18 % in 2012 in United Kingdom. Also, it is a risk factor for diseases like Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases. Conventional management (Modafinil, Sodium Oxybate and Stimulants) addresses only the subjective condition in EDS and is associated with adverse effects compromising the quality of life. In the current health scenario there is a need for alternative interventions to manage this disease. On analyzing this condition through &lt;em&gt;Ayurveda&lt;/em&gt;, we could understand it as &lt;em&gt;Nidradhikya&lt;/em&gt; (Excessive daytime sleepiness) which is caused due to vitiated &lt;em&gt;Kapha Dosha&lt;/em&gt; along with &lt;em&gt;Vriddha Tamoguna&lt;/em&gt; (increased &lt;em&gt;Tamoguna&lt;/em&gt;) that can be managed by &lt;em&gt;Shodhana&lt;/em&gt; (biopurification) followed &lt;em&gt;Shamana&lt;/em&gt; (pacification) therapies.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;This study was aimed to assess the combined effect of &lt;em&gt;Vamana&lt;/em&gt; (therapeutic vomiting) and &lt;em&gt;Sarasvata Churna&lt;/em&gt; in reducing Excessive Daytime Sleepiness.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;p&gt;This was a single-arm exploratory open-label clinical trial. 10 subjects having EDS diagnosed using Modified Epworth Sleepiness Scale (MESS) with a score of 10–24 with proper exclusion were recruited from OPD and IPD, Department of &lt;em&gt;Kāyacikitsa&lt;/em&gt;, Amrita School of Ayurveda. All the participants were clinically examined, sought for medical history and further checked biochemically to exclude any other systemic illness that may lead to this condition. Only healthy subjects with quality night sleep (assessed by PSQI) and without any other systemic illness were selected. The treatment protocol adopted was &lt;em&gt;Vamana Karma&lt;/em&gt; followed by 30 days of &lt;em&gt;Sarasvata Churna&lt;/em&gt; as &lt;em&gt;Shamana Aushadha&lt;/em&gt; (medicine for pacification). Assessment was done using MESS on 0&lt;sup&gt;th&lt;/sup&gt; day and after 30 days of &lt;em&gt;Shamana Aushadha Sevana.&lt;/em&gt; After completion of treatment, the results were statistically analysed using Wilcoxon Signed Rank Test and final conclusion was drawn.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;On analysis of the symptoms using Modified Epworth Sleepiness Scale, the mean total score reduced from 14.8 to 2.8 with 81.08 % relief in these 10 subjects and a significant p value &lt; 0.05 after &lt;em&gt;Vamana&lt;/em&gt; followed by 30 days of &lt;em&gt;Shamana Aushadha Sevana&lt;/em&gt;.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;p&gt;&lt;em&gt;Vamana&lt;/em&gt; helps in &lt;em&gt;Kapha Nirharana&lt;/em&gt; (expelling) which removes the &lt;em&gt;Avarana&lt;/em&gt; (occlusion) of &lt;em&gt;Manas&lt;/em&gt; seen in &lt;em&gt;Nidradhikya&lt;/em&gt;. This results ","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000755/pdfft?md5=614cdfc87ae8f05c98f54c92c8646586&pid=1-s2.0-S0975947624000755-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}