Journal of Ayurveda and Integrative Medicine最新文献

{"title":"In silico exploration of phytocompounds from AYUSH-64 medicinal plants against SARS CoV-2 RNA-dependent RNA polymerase","authors":"Srinivasulu Cheemanapalli ,&nbsp;Ramanjaneyulu Golla ,&nbsp;Sudhakar Pagidi ,&nbsp;Seshapani Pantangi","doi":"10.1016/j.jaim.2024.101026","DOIUrl":"10.1016/j.jaim.2024.101026","url":null,"abstract":"<div><h3>Background</h3><div>The AYUSH 64 formulation helps to treat mild to moderate cases of COVID-19. Although several drugs have been proposed to combat COVID-19, no medication is available for SARS-CoV-2 infection. The RNA-dependent RNA polymerase (RdRp) is the pivotal enzyme of SARS-CoV-2 replication, so it could be considered a better drug target for experimental studies.</div></div><div><h3>Objective</h3><div>The AYUSH-64 formulation plants exhibited multiple therapeutic properties; thus, the present study aims to screen the phytocompounds of these plants against SARS CoV2 RdRp to identify specific compounds that could potentially affect COVID-19 infection.</div></div><div><h3>Materials and methods</h3><div>PatchDock and AutoDock tools were used for docking experiments. MD simulations and Density Functional Theory (DFT) calculations of protein-ligand Picroside-I and Remdesivir complexes were carried out in GROMACS v2019.4 and Gaussian 09 software, respectively.</div></div><div><h3>Results</h3><div>Among the tested<strong>,</strong> five phytocompounds (Picroside I, Oleanolic acid, Arvenin I, II, and III) from AYUSH-64 medicinal plants showed possible binding with RdRp catalytic residues (Ser759, Asp760, and Asp761). Of these, Picroside I exhibited hydrogen bond interactions with NTP entry channel residues (Arg553 and Arg555). The MM-PBSA free energy, RMSD, Rg, PCA, and RMSF analysis suggested that the Picroside I complex showed stable binding interactions with RdRp in the 50 ns simulation. In addition to this, Picroside I revealed its robust and attractive nature toward the target protein, as confirmed by DFT.</div></div><div><h3>Conclusion</h3><div>The results of this study have proposed that Picroside I from AYUSH 64 medicinal plant compounds was the selective binder of catalytic and NTP entry channel residues of SARS-CoV2 RdRp thereby; it may considered as a potential inhibitor of SARS-CoV2 RdRp.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic management of hydatid cyst of lungs: A case report","authors":"Praveen K. Yadav ,&nbsp;Pradeep S. Shindhe ,&nbsp;Ramesh S. Killedar ,&nbsp;Mandeep Singh","doi":"10.1016/j.jaim.2024.101000","DOIUrl":"10.1016/j.jaim.2024.101000","url":null,"abstract":"<div><div>Cystic echinococcosis (CE), which is present in all parts of the world, is caused by the bacterium <em>Echinococcus granulosus.</em> One of the most serious parasitic infectious diseases affecting both humans and animals, CE causes hydatid cysts that can lodge in various host organs, including the liver, lungs, heart, and brain, which can be fatal. Treatment options for cystic echinococcosis are active anthelmintics, surgery, and percutaneous aspiration. Numerous scolicidal chemical agents are in practice, but due to increased drug resistance and adverse reactions associated with drugs, usage is limited. Finding alternative therapies with the least or no side effects to manage the condition is the need of the hour. Here, we report a case of an asymptomatic hydatid lung cyst that was managed using Ayurvedic treatment principles. A 57-year-old businessman, asymptomatic, came with a diagnosis of Hydatid lung disease confirmed by CT scan. Surgery was advised, but the patient approached for Ayurveda treatment. The case was treated with oral medicines like <em>Arogyavardhini gutika, Goarka, Kanchanara guggulu, Vidangasava, Kapalabhati pranayama</em> for a period of 8 months. Complete resolution of the cyst was seen, which was evident by a CT scan. Promising results were seen in the present case, but further research in this area is required to produce evidence-based results.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classical ayurveda management of TCH (taxane, carboplatin, and herceptin) based chemotherapy induced peripheral neuropathy- A case report","authors":"Zankhana Buch ,&nbsp;Suprabha Hegde ,&nbsp;Aishwarya Lakshmi ,&nbsp;Swathi Bhat","doi":"10.1016/j.jaim.2024.101044","DOIUrl":"10.1016/j.jaim.2024.101044","url":null,"abstract":"<div><p>Although empirical data on the influence of Ayurveda on Chemo/Radiotherapy-induced side effects are limited, its methodological framework, grounded in a 'systems thinking' perspective, enables the precise delineation of the pathogenic stage of these side effects. This, in turn, facilitates the development of a strategy to address the decline in the quality of life parameters commonly associated with cancer treatment. Ayurveda personalized approach to disease management typically involves providing customized diets, lifestyle adjustments, medications, and detoxification therapies that target the entire body.</p><p>We present a case involving a patient with numbness and pain in the right hand after undergoing chemotherapy who was referred to us by an oncologist for symptom management. This case report demonstrates the Ayurveda approach for establishing the etiology, pathogenesis, pathophysiology, and treatment of Chemotherapy-Induced Peripheral Neuropathy (CIPN) resulting from taxane-based chemotherapy. Following Ayurveda intervention, the patient exhibited significant improvements in symptoms and quality of life parameters.</p><p>This case report systematically illustrates the application of Ayurveda approach in CIPN management.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624001591/pdfft?md5=54366e63e4f13d6b195d6ea5fecbf6b7&pid=1-s2.0-S0975947624001591-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis focusing on the use of ayurvedic medicine in cerebral palsy","authors":"A.M.O. Rocha ,&nbsp;C.A. Len ,&nbsp;F.H. Santos ,&nbsp;S.B.O. Iglesias ,&nbsp;J.R. Bissoto","doi":"10.1016/j.jaim.2024.101035","DOIUrl":"10.1016/j.jaim.2024.101035","url":null,"abstract":"<div><div>Integrative practices have been incorporated into palliative care to provide holistic and multidimensional care for patients.</div><div>This study aims to identify the scope of integrative practices, specifically whole medical systems, and demonstrate its safety and efficacy, specially in children with cerebral palsy.</div><div>Key databases, including Embase, Cochrane, Medline/PubMed, Scopus, Google Scholar, Lilacs and Scielo were searched using specific terms.</div><div>Only randomized and non-randomized clinical trials were included for meta-analysis purposes. Case-control, cohort, cross-sectional or retrospective observational studies were also included for the systematic review. Participants included children aged 0–18 years receiving palliative care for cerebral palsy and undergoing Ayurvedic Medicine practices.</div><div>Descriptive analysis was conducted, including data such as year; author; design; sample size; intervention and comparison; outcomes and conclusion.</div><div>Two interventional studies compared Ayurvedic practices with each other or with physiotherapy in children with cerebral palsy. The meta-analysis demonstrated an improvement in spasticity for children using Ayurvedic medicine. However, there were limitations in terms of heterogeneity in interventions, control groups, and assessed outcomes.</div><div>Integrative practices, including Ayurvedic medicine have the potential to improve quality of life, manage disease symptoms and provide emotional support. However, more robust evidence is needed to support their widespread use. The use of Ayurvedic medicine showed evidence of improvement in spasticity for children with cerebral palsy.</div></div><div><h3>Registration number</h3><div>Prospero CRD 42020198399.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Ayurveda and modern mainstream medicine","authors":"K.P. Mohanan","doi":"10.1016/j.jaim.2024.100997","DOIUrl":"10.1016/j.jaim.2024.100997","url":null,"abstract":"<div><div>This article is an attempt to understand the challenge of integrating the education provided by BAMS programs and MBBS programs, in order to initiate the process of integrating research and practice in Ayurveda and Modern Mainstream Medicine. The specific issues discussed in the article are framed within the broader context of the challenge of integrating any two bodies of knowledge, theories, or knowledge systems in education and research.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction of journal clubs for UG students of Ayurveda, a dire necessity","authors":"Gaurav Soni","doi":"10.1016/j.jaim.2024.100977","DOIUrl":"10.1016/j.jaim.2024.100977","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurinformatics Laboratory- A synergy platform for Ayurveda and technology","authors":"Prashant Kumar Gupta ,&nbsp;Tanuja Manoj Nesari","doi":"10.1016/j.jaim.2024.101019","DOIUrl":"10.1016/j.jaim.2024.101019","url":null,"abstract":"<div><p>The Ayush sector has attained buoyant growth in the past decade as a science, public health, medicine, and industry. Artificial Intelligence, computational drug designing, and other combinatorial techniques could further accelerate the sector's growth. In this edition, we delve into the confluence of Ayurveda and technology, a theme that resonates profoundly in the contemporary healthcare and wellness landscape. The fusion of Ayurveda, an ancient system of medicine rooted in holistic well-being, with cutting-edge technology, is not just a paradigm shift but a necessary evolution in pursuing an integrated healthcare system where all systems have their defined, recognized, and respected contribution. Here, We are highlight one-such fusion initiative \"Ayurinformatics Laboratory\".</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624001347/pdfft?md5=66284fa327c82e9a05891c2fcff945d0&pid=1-s2.0-S0975947624001347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic management of systemic sclerosis - A case report","authors":"Jagruti R. Parmar ,&nbsp;Naiya Upadhyay ,&nbsp;Manish V. Patel ,&nbsp;Shivenarain N. Gupta","doi":"10.1016/j.jaim.2024.100956","DOIUrl":"10.1016/j.jaim.2024.100956","url":null,"abstract":"<div><p>Scleroderma, an autoimmune connective tissue disorder, leads to skin and tissue thickening. In this autoimmune disease condition, the defense mechanism works against the body itself and mistakenly attacks normal cells. Ayurveda links it to <em>vatarakta</em>, initially affecting <em>tvak</em>, <em>rakta</em>, and <em>mamsa</em>. <em>Vata</em> is primarily involved, but as the disease progresses, all <em>doshas</em> and <em>dhatu</em> get involved.</p><p>A 45-year-old woman presented with skin hardening, skin depigmentation all over her body, limb stiffness, weakness, arthralgia, anorexia, constipation and burning in the chest region for the last three years.</p><p>She was diagnosed with diffuse systemic sclerosis (SSc) but as per Ayurveda we can correlate with <em>aamvata</em> and <em>vatarakta</em> based on her <em>lakshanas</em>(symptoms).</p><p>Ayurvedic treatment commenced with <em>vardhamana pippali</em>(<em>Piper longum</em>)<em>rasayan</em>, <em>svedana karma</em>, and <em>virechan karma</em>, followed by <em>basti</em>(enema) <em>chikitsa (pathyadi kvath niruh basti)</em> and oral ayurvedic medication viz., <em>Manjisthadi kvatha</em>, <em>kaishora guggulu</em>, <em>Jatamansi(Nardostachys Jatamansi) churna, mishreya(Foeniculum vulgare) arka, dashang churna</em> with water for local application and daily <em>shamanarth panchtikta ghrit.</em></p><p>After 8 weeks, depigmentation was reduced, new hair growth emerged, mild skin softening occured, chest burning, anorexia, sleeplessness was decreased and enhanced mental well-being.</p><p>The treatment aimed to balance vitiated doshas and dhatu while alleviating symptoms, and enhancing overall well-being, demonstrating the efficacy of the holistic approach in managing scleroderma through Ayurveda.</p><p>Auto-immune disorder, scleroderma, chronic complications, skin tightness, salt pepper depigmentation, sclerodactyly.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000718/pdfft?md5=da9d36f463e172d0440b1f4e0ad8b25e&pid=1-s2.0-S0975947624000718-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Ayurvedic philosophy with modern technologies for drug research and development: A critical need of mechanistic insights for wider acceptability","authors":"Chavan Sandeep ,&nbsp;Vidya Gupta ,&nbsp;Vineeta Deshmukh ,&nbsp;Sadanand Sardeshmukh","doi":"10.1016/j.jaim.2024.100954","DOIUrl":"10.1016/j.jaim.2024.100954","url":null,"abstract":"<div><div>Ayurveda is a holistic science emphasizing healing and maintaining harmony and balance in the body. Medicines from natural resources and in pre-defined dosage forms are integral parts of successful Ayurvedic treatment in various diseases including complex ailments, such as cancer. Ayurvedic medicines are cocktails of several active phyto-compounds and/or natural resources and no isolated/purified molecules are used in the treatment. However, various unique methods employed using natural media, such as water, lipids, buttermilk, and lemon juice, just to name a few, lead to the elimination of unwanted constituents/impurities and enhance the bioavailability and efficacy of the drug. Such plausible alterations, selection, and/or retention of signature phytocompounds in the raw materials, during the process, and in the final drug need to be studied for precise product identification and analysis. Critical standardization of the manufacturing procedures is, therefore, mandatory for quality fidelity, assurance, and optimum efficacy. Moreover, the simultaneous multi-level and/or multi-targeted actions of Ayurvedic medicines against various dysfunctions due to their complex nature makes it extremely challenging to understand the mechanistic aspects during pre-clinical and clinical studies.</div><div>The present article focuses on probable challenges and ideal roadmaps for standardization and characterization of such herbal as well as metallic-mineral Ayurvedic medicines being used for various simple and complex diseases like cancer and their treatments. It is emphasized that Ayurvedic manufacturing procedures should be followed meticulously and the finished product be characterized thoroughly using advanced pharmaceutical and analytical techniques. It is also accentuated that detailed monographs or dossiers including shelf-life studies need to be officially published for knowledge dissemination and worldwide acceptance. Finally, safety and efficacy studies as per modern pharmacology ought to be conducted in suitable animal models for the judicious use of these medicines. Mainstream or adjuvant treatment of dreadful diseases such as cancer with Ayurvedic medicines will only be fruitful through rational experimentation and ethical reporting.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Arvind Kulkarni,&nbsp;Swapna Kulkarni,&nbsp;Vasanti Godse,&nbsp;Shrinivas Datar,&nbsp;Sushama Bhuvad,&nbsp;Shweta Gujar,&nbsp;Sameer Gore,&nbsp;Bhagyashree Sardeshmukh,&nbsp;Vinita Awalkanthe,&nbsp;Anita Shingte,&nbsp;Sneha Dalvi,&nbsp;Vijay Radye,&nbsp;Sandeep Chavan","doi":"10.1016/j.jaim.2024.101070","DOIUrl":"10.1016/j.jaim.2024.101070","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of brain tumors poses a significant threat, particularly with high-grade tumors that exhibit rapid growth and can significantly impair the patient's quality of life, despite treatment modalities. Ayurveda, a natural system of medicines helps to enhance health benefits when used as a complementary therapy in combination with conventional treatment through various herbal, herbo-mineral or herbo-mineral-metallic formulations. One of such formulations, <em>Raupya Suvarna Sutshekhara (RSS),</em> has <em>Raupya bhasma</em> and <em>Suvarna bhasma</em> (incinerated Silver and Gold respectively) ingredients and they are described as <em>Rasayana</em> (immunomodulatory) and possess <em>Medhya</em> (enhances the brain functions and intelligence) activity.</div></div><div><h3>Objective</h3><div>The study documents effects of <em>Raupya Suvarna Sutshekhara</em> in alleviating symptoms of malignant brain tumors.</div></div><div><h3>Materials and methods</h3><div>This retrospective cohort study was done for malignant brain tumor patients (n = 110) registered at our centre who were treated with <em>Raupya Suvarna Sutshekhara</em> 125 mg–250 mg (a herbo-mineral metallic formulation) as a treatment of choice of neural tonic along with supporting Ayurvedic medicines. Treatment response evaluation period ranged from 3 months to 5 years (median period 29 weeks). Clinical symptoms, weight, Karnofsky Performance Score (KPS), Quality of Life (QoL) score, and survival data with respect to treatment with RSS were analyzed.</div></div><div><h3>Results</h3><div>RSS showed a very significant (<em>p</em> &lt; 0.001) effect on symptoms related to memory loss, headache, imbalance, loss of appetite, and generalized weakness while significant (<em>p</em> &lt; 0.05) decrease in urinary incontinence, seizures, difficulty in thinking/articulating, and weakness in one part/side of the body. However, a not-quite significant change was seen in symptom confusion/disorientation. No significant improvement was seen in vision changes, facial numbness or tingling, swallowing difficulties, and tingling in extremities. Body weight and KPS also showed improvement. Patients with treatment between 2 and 5 years showed median survival up to 62 months.</div></div><div><h3>Conclusions</h3><div>It was observed that adjunct Ayurvedic treatment with RSS helped to reduce the severity of symptoms due to the tumor itself or side-effects of conventional treatments, maintain the quality of life of malignant brain tumor patients and has shown to increase survival with respect to the duration of the treatment.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}