Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Evaluation of fertility toxicity and embryo-fetal developmental toxicity profile of Ayush AG, a compound herbo-mineral Ayurvedic formulation","authors":"Shrirang B. Jamadagni ,&nbsp;Mukul Tambe ,&nbsp;M. Srinivasan ,&nbsp;Sudesh Gaidhani ,&nbsp;Goli Penchala Prasad ,&nbsp;Sudhir Matte","doi":"10.1016/j.jaim.2025.101154","DOIUrl":"10.1016/j.jaim.2025.101154","url":null,"abstract":"<div><h3>Background</h3><div>It is essential to generate the reproduction toxicity data of any drug that will be used in pregnancy or during the reproductive phase of life. Ayush AG, a compound herbo-mineral Ayurvedic formulation that is developed for promoting the health of the fetus and mother, was tested to assess its reproductive toxicity profile as per the standard guidelines.</div></div><div><h3>Materials and method</h3><div>In the fertility toxicity study, Ayush AG, the test drug was administered in three graded doses to Wistar rats (40 male and 40 female) during the premating, mating period, gestation, and lactation periods. Parameters such as estrous cycle, body weight, feed consumption, hematology, serum biochemistry, pup body weight, hematology and biochemistry, histopathology of reproductive organs and reproductive indices were studied. In the embryo-fetal developmental toxicity study, the test drug was administered from day 7 to day 9 of the gestation period in 18 pregnant rats and sacrificed on gestation day 20. Parameters such as body weight during gestation, uterus weight, fetus and placenta weight, gross examination of fetuses for sex, external and visceral anomalies were studied.</div></div><div><h3>Results</h3><div>In the fertility toxicity study, no adverse effect on mating behaviour, estrus cycle, conception rate, body weight, hematological and biochemical parameters, pup growth, or histopathology was found at dose level of 750 mg/kg of Ayush AG. No teratogenic changes were observed in the fetuses in the embryo-fetal developmental toxicity study at dose level of 750 mg/kg.</div></div><div><h3>Conclusion</h3><div>Ayush AG, the compound herbo-mineral Ayurvedic formulation, has been demonstrated to be safe at the dose of 750 mg/kg in fertility toxicity and embryo-fetal developmental toxicity studies in Wistar rats.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101154"},"PeriodicalIF":1.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of eight-week therapy with Ashwagandha root extract in improvement of sexual health in healthy men: Findings of a prospective, randomized, double-blind, placebo-controlled study","authors":"Amit Shrenikraj Mutha ,&nbsp;Sonali Amit Mutha ,&nbsp;Anupama Hem Tejuja ,&nbsp;Amit Shashikant Beldar ,&nbsp;Alok Mahendra Mulay ,&nbsp;Deepak Langade","doi":"10.1016/j.jaim.2025.101155","DOIUrl":"10.1016/j.jaim.2025.101155","url":null,"abstract":"<div><h3>Background</h3><div>Ashwagandha, a traditional Indian Ayurvedic remedy, an adaptogen, may improve sexual dysfunction in men and women.</div></div><div><h3>Objective</h3><div>This 8-week prospective, double-blind, randomized, placebo-controlled study evaluated the efficacy and safety of Ashwagandha Root Extract (ARE) on improving sexual health in healthy adult men.</div></div><div><h3>Method</h3><div>A total of 100 healthy men aged 30–50 years were randomly assigned to receive ARE 300 mg twice daily (n = 50), or identical placebo (n = 50) in a 1:1 ratio for 8 weeks. Study assessments such as Satisfying Sexual Events (SSEs), the Sexual Desire Inventory (SDI-2), the International Index of Erectile Function (IIEF) score, semen parameters and the Quality of Life (QOL) were done using the SF-12 tool at baseline, week 2, week 4, and week 8. Three participants from ARE and four participants from the placebo group were excluded due to follow-up loss. The efficacy analyses were done on Per-Protocol (PP) dataset of 93, whereas safety analyses were done on all 100 participants.</div></div><div><h3>Results</h3><div>Significant improvements were observed with ARE for semen volume (p = 0.005), sperm number (p = 0.006), sperm concentration (p = 0.007), and sperm morphology (p = 0.007). The improvement in scores was better with ARE for SDI-2 (p &lt; 0.05), orgasm and sexual desire domains of IIEF (p &lt; 0.05), and SF-12 (p &lt; 0.0001). No adverse events were reported in the study.</div></div><div><h3>Conclusion</h3><div>Ashwagandha improved the orgasmic function, sexual desire and overall sexual satisfaction with the 8-week of oral administration. It was well tolerated as it showed no significant changes in hepatic and renal parameters in blood.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101155"},"PeriodicalIF":1.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards standardization of Prakriti Evaluation: A scoping review of modern assessment tools and their psychometric properties in Ayurvedic medicine","authors":"Ankit Gupta ,&nbsp;Varsha Singh ,&nbsp;Sushil Chandra ,&nbsp;Rahul Garg","doi":"10.1016/j.jaim.2025.101157","DOIUrl":"10.1016/j.jaim.2025.101157","url":null,"abstract":"<div><h3>Background</h3><div>Ayurveda is an ancient Indian medical system that emphasizes individualized care based on the concept of <em>Prakriti</em>, which represents an individual's relative proportion of three <em>doshas</em> (humour) at the time of conception. <em>Prakriti</em> is believed to remain unchanged throughout one's life span, and based on the relative preponderance of <em>doshas</em>, it has been classified into ten types. Researchers and practitioners have developed various assessment tools, such as questionnaires, algorithmic and machine learning-based methods, and devices to bring objectivity and replicability to the <em>Prakriti</em> evaluation procedure. However, a systematic evaluation of their effectiveness and psychometric properties is currently lacking in the literature.</div></div><div><h3>Objective</h3><div>To identify <em>Prakriti</em>, classical Ayurveda texts suggest various techniques, but subjective variations and bias in interpretation have been reported among practitioners.</div></div><div><h3>Methods</h3><div>This scoping review aims to identify modern <em>Prakriti</em> assessment tools available in scientific literature and describe their psychometric properties to contribute to the development of more effective and standardized methods for <em>Prakriti</em> evaluation. Employing Arksey and O'Malley's five-stage methodological framework, the review critically assesses <em>Prakriti</em> evaluation tools, such as questionnaires, machine learning algorithms, and devices, to provide insights into the robustness and accuracy of these assessment methods.</div></div><div><h3>Results</h3><div>Thirty-two studies meeting the inclusion criteria were included in the review. Sixteen studies utilized questionnaires for <em>Prakriti</em> assessment, of which three were validated, six had established reliability, and three had both reliability and validity confirmed. Five studies employed algorithm-based methods, with three of these using validated machine learning models. Eleven studies utilized devices to assess <em>Prakriti</em> types, with only one device validated and providing access to data for reproducibility. Questionnaires were the most commonly used tools for <em>Prakriti</em> evaluation, followed by algorithm-based methods and devices.</div></div><div><h3>Conclusion</h3><div>Questionnaires are the most validated tools presently for <em>Prakriti</em> assessment despite their limited psychometric robustness. Machine learning based models show potential but suffers challenges in accuracy, replicability and finding the ground truth in a robust manner, and devices are the most objective assessment tools though none of them have been appropriately validated. Despite these limitations, <em>Prakriti</em> diagnosis is a promising field that requires robust procedures to establish standardized, replicable and reliable measures for its evaluation.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101157"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated treatment approach to Miller Fisher syndrome, a variant of Guillain-Barre syndrome – A case report","authors":"Pankaj Yadav ,&nbsp;Vaishali Kuchewar ,&nbsp;Nikita Bhusari ,&nbsp;Tanika Yadav","doi":"10.1016/j.jaim.2025.101159","DOIUrl":"10.1016/j.jaim.2025.101159","url":null,"abstract":"<div><div>Guillain-Barre syndrome (GB Syndrome) is an acute inflammatory immune-mediated polyneuropathy having, progressive weakness, and pain in limbs. An extended illness can potentially be devastating due to respiratory problems and autonomic dysfunction. Despite the effectiveness of IV Ig and plasma exchange, most GBS patients develop severe weakness and have a prolonged disease course, typically with incomplete recovery. This is a case of a 51-year-old male patient diagnosed with Guillain-Barre syndrome (acute motor axonal neuropathy with Miller Fisher syndrome). GBS was correlated with <em>sarvangagata vata</em> and was treated by an integrated approach including Ayurveda treatment, Physiotherapy and some modern medication. There was significant improvement in motor functions and he recovered completely within 60 days. According to the case facts, it may be inferred that an integrated therapeutic approach may facilitate a speedy recovery in Guillain-Barre syndrome.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101159"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of the traditional Pudam process in the manufacturing of Siddha medicine Anna Pavala Chendooram by using an innovative electrical device","authors":"A.S. Ganesh Kumar ,&nbsp;Senthilvelan Selvaraj ,&nbsp;V.M. Ravichandran ,&nbsp;P Selva Shunmugam ,&nbsp;V. Kamalanathan","doi":"10.1016/j.jaim.2025.101156","DOIUrl":"10.1016/j.jaim.2025.101156","url":null,"abstract":"<div><div><strong>Background:</strong> The Siddha medicine system is one of the oldest traditional medicine systems and requires engineering equipment to reduce skill dependency for medicine manufacturing without compromising the efficacy of the medicine. <strong>Objective:</strong> The objective of the current work was to study the standard manufacturing method for a Siddha medicine <em>anna pavala chendooram</em> as per the conventional method and manufacture it in an electrical device designed for <em>pudam</em> process characterize it. <strong>Material and methods:</strong> <em>Annabedhi</em> (Ferrous sulfate) and <em>kodipavalam</em> (Coral) were taken as raw materials, <em>anna pavala chendooram</em> was prepared in the pit per conventional methods, and the same medicine was prepared in an electrical device for <em>pudam</em>; the prepared medicine from the pit and the device were characterized using modern scientific methods. <strong>Results:</strong> The maximum pressure built inside the sealed <em>agal</em> during the <em>pudam</em> was 35 mbar, and the maximum temperature during the <em>pudam</em> captured was 635 °C at the bottom. The XRD analysis reveals that the raw material consists of Fe₂O₃ (H₂O)₄, 2Fe (OH) SO₄, and CaSO₄ (H₂O)_4, and the finished medicine consists of Fe₂O₃ and CaSO₄. The XRF analysis reveals that the major oxides in finished medicines were Fe₂O₃(T), SO₃, CaO, and MgO. The average particle size of finished medicine from the pit is 6.52 μm, and the finished medicine from the device with <em>seelaimann</em> is 6.45 μm, and from the device without <em>seelaimann</em> is 6.28 μm. <strong>Conclusion:</strong> The <em>pudam</em> process for making <em>anna pavala chendooram</em> can be done using the device for <em>pudam</em> with the temperature profile obtained from the pit.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101156"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Withania somnifera derived natural products as promising inhibitors of Mycobacterium tuberculosis Pantothenate Kinase-PanK: An integrated in silico and in vitro approach","authors":"Ankita Singh ,&nbsp;Usha Mina ,&nbsp;Pardeep Yadav","doi":"10.1016/j.jaim.2025.101158","DOIUrl":"10.1016/j.jaim.2025.101158","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis remains a pervasive and enduring global health challenge, with the alarming rise of drug-resistant variants. <em>Mycobacterium tuberculosis</em> (<em>M. tuberculosis</em>), bacterium responsible for tuberculosis, deploys a complex arsenal of virulence factors to evade the host’s immune defences. The quest for novel targets or compounds to combat drug-resistant <em>M. tuberculosis strains</em> is of paramount importance. PanK is an essential enzyme for Co-enzyme A (CoA) biosynthesis pathway, targeting inhibition of its activity by <em>Withania somnifera</em> phytochemicals may provide an effective therapeutic strategy against resistant strains.</div></div><div><h3>Objective</h3><div>The study aims to identify the potential of natural compounds derived from <em>Withania somnifera</em> as inhibitors of the PanK enzyme (novel target) in <em>M. tuberculosis</em>.</div></div><div><h3>Methodology</h3><div><em>In silico</em> computational approach, includes steps-structure based virtual screening of 83 Withania compounds followed by molecular docking and dynamic simulations spanning 100 ns, to assess the binding affinity and stability between screen key compounds and PanK. <em>In vitro</em> anti-tuberculosis bioassays was also performed to validate the <em>In silico</em> experiments finding.</div></div><div><h3>Result</h3><div>Through <em>in silico</em> experiments, four key compounds of <em>Withania somnifera were</em> —Morkotin A, Rutin, Withaoxylactone, and 2,3-Dihydrowithanolide E were identified. They exhibited strong potential to inhibit PanK enzyme activity. The <em>In silico</em> as well as <em>In vitro</em> findings suggest that <em>Withania somnifera</em>-derived natural compounds could serve as effective candidates for targeting vital enzymes in <em>M. tuberculosis</em>.</div></div><div><h3>Conclusion</h3><div><em>Withania somnifera</em> can be explored as valuable resource for developing novel drugs for PanK as a target to combat tuberculosis.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101158"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents","authors":"Mukul S. Tambe ,&nbsp;Shreyas R. Shinde ,&nbsp;Akshay M. Baheti ,&nbsp;Shuchi Nagar ,&nbsp;Anil T. Pawar","doi":"10.1016/j.jaim.2024.101088","DOIUrl":"10.1016/j.jaim.2024.101088","url":null,"abstract":"<div><h3>Background</h3><div><em>Withania somnifera</em> (L.) Dunal, commonly known as ashwagandha, is an Ayurvedic herb belonging to the family Solanaceae.</div></div><div><h3>Objectives</h3><div>This study aims to explore the analgesic, anti-inflammatory and anti-arthritic potential of phytoconstituents of <em>Withania somnifera</em> (L.) Dunal (<em>W. somnifera</em>) by network pharmacology and <em>in-silico</em> docking studies.</div></div><div><h3>Methods</h3><div>Five major phytoconstituents, namely ashwagandhanolide, quercetin, withaferin A, withanone and withanolide A, were selected for the network pharmacology study. All five phytoconstituents were further evaluated for their binding properties using molecular docking (MD) and simulation tools. The compounds that exhibited significant binding affinities were further studied for pharmacokinetic and toxicity (ADMET) predictions.</div></div><div><h3>Results</h3><div>The network pharmacology study showed that out of the five selected constituents, withaferin A, withanolide A and quercetin can interact with various inflammation and pain-related genes. In <em>in-silico</em> studies, all five constituents were found to have significant interactions with inflammatory and nociception proteins cyclooxygenases, lipoxygenase, myeloperoxidase and cathepsin B. Further, ADMET studies predicted that all five phytoconstituents could not cross the blood-brain barrier but have high gastrointestinal absorption and bioavailability. Quercetin was predicted to have mutagenic potential and the other three constituents (withaferin A, withanone and withanolide A) were predicted to have immunotoxicity. The MD simulation studies showed that the complexes lipoxygenase_ashwagandhanolide and cathepsin B_ashwagandhanolide exhibit lower RMSD, RMSF, and higher H-bonding, indicating greater stability of ashwagandhanolide with lipoxygenase and cathepsin B.</div></div><div><h3>Conclusion</h3><div>Ashwagandhanolide, quercetin, withaferin A, withanone, and withanolide A from <em>W. somnifera</em> may show the potential for analgesic, anti-inflammatory, and anti-arthritic activities. These findings provide a foundation for future <em>in</em>-<em>vitro</em> and <em>in</em>-<em>vivo</em> studies to confirm the therapeutic efficacy of these phytoconstituents from <em>W. somnifera</em>.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101088"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Epidermolysis Bullosa through Ayurveda- a case report of two siblings","authors":"Kuldeep Kavathiya ,&nbsp;Jitesh Verma ,&nbsp;Umakant Tiwari ,&nbsp;Bharat Bhoyar ,&nbsp;Anamika","doi":"10.1016/j.jaim.2025.101149","DOIUrl":"10.1016/j.jaim.2025.101149","url":null,"abstract":"<div><div>Epidermolysis bullosa (EB) is a group of inherited rare skin disorders that causes the skin to become fragile and blister easily due to minor trauma or friction. Blisters can appear anywhere on the body. There are limitations in treating this disease in the conventional system of medicine. This paper elaborates on the case of two siblings who presented with blisters all over the body with itching, discharge, difficulty in walking, and disfigurement of fingers, toes, and feet. Based on Ayurvedic clinical assessment, the condition was diagnosed as <em>Kapha-pitta</em> dominant <em>Tridoshaja Visphota</em>. They were treated through Ayurveda on the line of <em>Visphota</em> (a type of <em>Kushtha</em>/skin disorder) with the use of <em>Dipana</em> (digestion and metabolism-enhancing), <em>Pachana</em> (enhancing digestion), and <em>Mridu Shodhana</em> (mild bio-cleansing) medicines. Both patients have shown improvement with a reduction in EBDASI (Epidermolysis bullosa disease activity and scaring index) from 174 to 45 and 176 to 39, respectively, in the first and second sibling with 4 months of ayurvedic medication. No relapse was seen in both patients during the next one year. The case study is unique as EB is a genetic disorder with limitations in its management in the conventional system of medicine. Moreover, the authors could not find any published case of EB managed through Ayurveda treatment. Thus, it opens new areas of research in the management of EB through traditional systems of medicine like Ayurveda.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101149"},"PeriodicalIF":1.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 14 years overall survival of a patient with stage IV carcinoma of cervix with lung metastasis - A case report of Ayurveda based integrative approach","authors":"Sadanand Prabhakar Sardeshmukh,&nbsp;Vineeta Vasant Deshmukh,&nbsp;Arvind Vishnu Kulkarni,&nbsp;Shweta Rakesh Gujar,&nbsp;Nilambari Sushrut Sardeshmukh,&nbsp;Bhagyashree Sukumar Sardeshmukh,&nbsp;Vinita Sanjog Awalkanthe,&nbsp;Suchita Kishor Shiraskar,&nbsp;Dhananjay Ravindra Deshpande,&nbsp;Sandeep Bhagwan Chavan,&nbsp;Vidya Shrikant Gupta","doi":"10.1016/j.jaim.2024.100990","DOIUrl":"10.1016/j.jaim.2024.100990","url":null,"abstract":"<div><h3>Background</h3><div>Carcinoma of the cervix is a leading cause of cancer-related mortality in women. The commonest metastatic site in cervical cancers is lung. Prognosis of cervical cancer with lung metastasis is very poor.</div></div><div><h3>Case presentation</h3><div>The present patient, an inhabitant of rural India, was diagnosed with squamous cell carcinoma of cervix in stage III, grade II in July 2011. She underwent radical course of pelvic radiotherapy along with concurrent weekly chemotherapy, also received two sittings of brachytherapy after completing external beam radiotherapy. Before initiating radical radiotherapy in 2011, she received a combination of personalised/tailored herbo-mineral Ayurvedic medicines for 1 year and 10 months with an aim to minimise the side effects of radiotherapy. After completing radiotherapy, she was treated with a set of Ayurvedic medicines mainly to boost her immunity and to prevent recurrence. She was asymptomatic with good quality of life; all her radiological and biochemical parameters were within normal range till 2016. During her routine periodic investigations in March 2016, X-ray chest revealed nodular opacity on peripheral aspect of left mid zone. Patient underwent CT guided left lung mass biopsy which confirmed the diagnosis as squamous cell carcinoma of left lung (non-small cell type). At this point, the primary cancer was metastasized to lung and upgraded from stage III to stage IV. For this, she was treated with palliative course of radiotherapy. She has been taking regularly oral Ayurvedic medicines till date.</div></div><div><h3>Conclusion</h3><div>Progression free survival of six years and overall survival of 14 years along with exceptional good quality of life has been observed in Stage IV cervical cancer patient with lung metastasis. This has been achieved by integrative approach of conventional cancer treatment of radiotherapy and personalised adjunct Ayurvedic treatment containing combination of oral herbo-mineral metallic medicines.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 100990"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions, knowledge, attitude, practices and barriers towards research among Ayurveda interns: A cross - sectional pilot study","authors":"Arati Darvajkar ,&nbsp;Urmila Shirke ,&nbsp;Amruta Kakade ,&nbsp;Asmita Wele ,&nbsp;Jijaba Shirke","doi":"10.1016/j.jaim.2025.101150","DOIUrl":"10.1016/j.jaim.2025.101150","url":null,"abstract":"<div><h3>Background</h3><div>Research in Ayurveda takes the form of discovery of many scientific principles that guide innovations and evidence based clinical practice. It has been essential part of basic Ayurvedic education for over a decade, which provides ground for evaluation.</div></div><div><h3>Objective</h3><div>This study aims to evaluate the perceptions, knowledge, attitude, practices and barriers towards research among Ayurveda interns, and to identify factors that may influence them.</div></div><div><h3>Methods</h3><div>A cross sectional study was carried out between the period of September 30, 2023 and October 30, 2023 amongst Ayurveda interns from all over India. Data was collected using a validated questionnaire and disseminated via google forms. The questionnaire was based on Perception, Knowledge, Attitude, Practice and Barriers towards research domains. A total of 28 questions were included in the questionnaire. 21 questions were assessed using Likert scale, 3 questions with 1–10 Rating Scale and 4 questions were yes and no type.</div></div><div><h3>Results</h3><div>A total of 199 participants from 31 different colleges and from 9 states responded to the survey<strong>.</strong> The mean age of study participants was 23.73 (SD = 1.854). Most of the students had a positive approach and willingness to participate in medical research, but the most challenging factor in maintaining their interest was mentoring and guidance. This survey highlights a few barriers like time constraints, insufficient motivation, mentorship gaps and limited awareness of sources of funding for research among Ayurveda graduates. Appropriate measures to overcome these barrier might be very useful in changing the perception, willingness and attitude of the students.</div></div><div><h3>Conclusion</h3><div>Fresh graduates in Ayurveda are open to meaningful research if they can find competent mentors and guidance.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 4","pages":"Article 101150"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}