Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Evaluation of Yograj Guggulu, Ashwagandha Churna and Narayana Taila in management of Osteoarthritis Knee: A study in tribal dominant community","authors":"Kalpana Kachare ,&nbsp;Deepa Makhija ,&nbsp;Abha Sharma ,&nbsp;Sunita ,&nbsp;N. Srikanth ,&nbsp;B.S. Sharma ,&nbsp;Rakesh Rana ,&nbsp;Arunabh Tripathi ,&nbsp;B.C.S. Rao ,&nbsp;Purnendu Panda ,&nbsp;Ekta ,&nbsp;Raghavendra Naik ,&nbsp;K. Nishanth ,&nbsp;U.R. Shekhar Namburi ,&nbsp;Vimal Tiwari ,&nbsp;S.B. Singh ,&nbsp;Monika ,&nbsp;P. Srinivas ,&nbsp;Vipin Sharma ,&nbsp;Anil Avhad ,&nbsp;Abhaydev","doi":"10.1016/j.jaim.2024.101077","DOIUrl":"10.1016/j.jaim.2024.101077","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) is the most prevalent joint disease and a major cause of joint impairment and physical debility, common in elderly, women and laborious workers. The available non-steroidal anti-inflammatory drugs (NSAID) are being prescribed to manage the condition; however, newly discovered alternatives are looked upon by the practitioners. Thus, the study was aimed to provide an effective and safer alternative through Ayurveda for the management of OA.</div></div><div><h3>Objective</h3><div>To document the role of the selected Ayurveda formulations in the management of OA and to assess the tolerability of the formulations.</div></div><div><h3>Material and methods</h3><div>It was an open-label, multicentric, single-arm, prospective, study conducted at 14 peripheral institutes of the Central Council for Research in Ayurvedic Sciences, New Delhi. 483 participants of any gender between the age 40 to 65 years diagnosed with OA knee as per the ACR diagnostic criteria (2012) and willing to provide consent were enrolled in the study. Oral administration of Ayurvedic formulations Yograj Guggulu, Ashwagandha Churna and the local application of Narayana Taila was given for 12 weeks and assessment was done by means of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Modified-CRD, Pune version Score, Visual Analogue Scale score and disease-specific symptoms on 28th, 56th, 84th and 112th day.</div></div><div><h3>Results</h3><div>Significant change (P&lt;0.001) was observed in WOMAC score, VAS score and cardinal symptoms of OA knee. No adverse events reported in the study and the study drugs were well tolerated by the participants.</div></div><div><h3>Conclusion</h3><div>The study substantiates that administration of Yograj guggulu, Ashwagandha Churna and Narayana Taila, is well acceptable and tolerable. The interventions effectively alleviate the cardinal symptoms of OA knee.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101077"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-invasive Ayurveda management of venous leg ulccer- A case report","authors":"Archana Muraleedharan,&nbsp;Sree R. Nair,&nbsp;P.N. Rajeshwari","doi":"10.1016/j.jaim.2024.101073","DOIUrl":"10.1016/j.jaim.2024.101073","url":null,"abstract":"<div><div>Venous leg ulcer (VLU) is a severe complication of chronic venous insufficiency that commonly affects older individuals. It is a long-standing consequence of venous insufficiency and accounts for 70%–80% of lower limb ulcers seen in outpatient departments. These ulcers are often unresponsive to treatment and can significantly impact patients' quality of life, causing pain, sleep disturbances, and decreased mobility. Managing varicose leg ulcers is a significant challenge for physicians.A 55-year-old male presented with symptoms including pain, stiffness, discoloration, swelling in the left lower limb, and a history of non-healing ulcer. The patient was treated with <em>Patrad</em><em>a</em><em>na</em> using leaves of <em>Ricinus communis</em> (<em>Eranda patra</em>) and <em>Grihadhum</em><em>a</em><em>di lepa</em> along with oral medications such as <em>Triphal</em><em>a</em> <em>Guggulu</em> and <em>Gandhaka Ras</em><em>a</em><em>yana</em>. Each day, the change was carefully observed and documented, revealing a notable improvement by the end of the treatment (10 days). The pain, swelling, and stiffness exhibited significant reduction, accompanied by wound healing after the first follow-up of 14 days. The complete wound healing was achieved and quality of life showed improved. The patient has beenunder observation and has not reported any recurrence of ulcer in the 4 months of follow up.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101073"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe and effective management of psoriasis through Ayurveda: A case report","authors":"Guruprasad C. Nille ,&nbsp;Monisha Bhuyan ,&nbsp;Laxmi Narayan Gupta ,&nbsp;Anand Kumar Chaudhary","doi":"10.1016/j.jaim.2024.101091","DOIUrl":"10.1016/j.jaim.2024.101091","url":null,"abstract":"<div><div>Ayurveda, an ancient system, offers in-depth insights into various skin disorders. It provides detailed understanding of causative factors and pathomechanisms, along with time-tested traditional treatments based on its principles. We report a 16-year chronic case of psoriasis (36-year-old male patient) with plaques and peeling erythrodermic skin rashes over the back and front of the trunk area and both legs. The scalp area and nail beds were also affected. The early involvement of joints was also noted. A two-year multimodal Ayurveda treatment has shown notable efficacy in managing chronic plaque and erythrodermic psoriasis, with no reported adverse events or side effects. The progressive events were documented in the form of photographs with the proper consent of the patient. The Ayurveda medicines, strict dietary regimen, and regular follow-ups together resulted in promising outcomes, revalidating the potential of Ayurveda in controlling psoriasis and its complications.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101091"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting cell cycle arrest in breast cancer by phytochemicals from Caryto urens L. fruit ethyl acetate fraction: in silico and in vitro validation","authors":"Ghanshyam Parmar,&nbsp;Jay Mukesh Chudasama,&nbsp;Ashish Shah,&nbsp;Chintan Aundhia,&nbsp;Sunil Kardani","doi":"10.1016/j.jaim.2024.101095","DOIUrl":"10.1016/j.jaim.2024.101095","url":null,"abstract":"<div><h3>Background</h3><div><em>Caryota urens</em>, also known as Shivjata, has been documented in ancient Indian texts for its therapeutic benefits, addressing conditions from seminal weakness to gastric ulcers. This study aims to investigate its contemporary medicinal potential in treating breast cancer.</div></div><div><h3>Objectives</h3><div>The study focuses on exploring the therapeutic potential of <em>Caryota urens</em> fruit against breast cancer, specifically targeting cell cycle genes CDK1, CDC25A, and PLK1 through bioinformatics, network pharmacology, and in vitro validation.</div></div><div><h3>Materials and methods</h3><div>Using mass spectrometry and nuclear magnetic resonance (NMR), 60 key phytoconstituents from <em>Caryota urens</em> fruit were identified. Bioinformatics analysis, integrating Gene Cards and GEO databases, 15,474 breast cancer-associated genes focusing on the HR+/HER2-subtype were identified. Molecular docking and qPCR validated the interactions of key phytoconstituents, particularly Episesamin, with CDK1, CDC25A, and PLK1. In vitro studies were conducted on the MCF7 cell line, supplemented by ROC and survival analyses to evaluate diagnostic and therapeutic potential.</div></div><div><h3>Results</h3><div>The bioinformatics analysis identified CDK1, CDC25A, and PLK1 as pivotal genes regulating cell cycle progression and breast cancer tumorigenesis. Network pharmacology and in vitro studies indicated that phytoconstituents, especially Episesamin, downregulated these genes in breast cancer cells. Molecular docking and qPCR confirmed these interactions, and ROC and survival analyses underscored their diagnostic and therapeutic significance.</div></div><div><h3>Conclusions</h3><div>This study suggests that <em>Caryota urens</em> fruit extract, particularly Episesamin, may inhibit breast cancer metastasis by downregulating CDK1, CDC25A, and PLK1, offering promising new strategies for targeting the cell cycle in breast cancer and emphasizing the value of integrating bioinformatics with experimental methods in cancer research.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101095"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular insights into anti-inflammatory activities of selected Indian herbs","authors":"Saumya Upadhyay ,&nbsp;Rajan swami ,&nbsp;Shweta Shrivastava ,&nbsp;Manish Kumar Jeengar","doi":"10.1016/j.jaim.2024.101081","DOIUrl":"10.1016/j.jaim.2024.101081","url":null,"abstract":"<div><div>Inflammation is a universal response of mammalian tissue to harm, comprising reactions to injuries, pathogens, and foreign particles. Chronic inflammation, often present in allergies and autoimmune disorders, poses significant risks, potentially leading to conditions such as rheumatoid arthritis, Alzheimer's disease, asthma, and inflammatory bowel disease. It can also be a common precursor to cancer. However, Contemporary therapies like NSAIDs and corticosteroids often provide incomplete relief from chronic inflammation and carry significant side effects, underscoring the need for exploring traditional and plant-based medicines for new, effective treatments. As such, there is a growing demand for natural bioactive substances for health maintenance and disease risk reduction. Traditional and plant-based medicines, long-used in managing inflammation and other disorders, hold promise for the discovery of bioactive lead compounds and subsequent drug development for treating inflammatory disorders. This review encompasses an extensive study of the anti-inflammatory potential of selected traditional Indian herbal medicines and the associated pharmacological mechanisms of action. The inflammatory process often entails the activation of transcription factors, induction of various signaling cascades, gene expression, activation of inflammatory enzymes, and release of pro-inflammatory cytokines in inflammatory or immune cells. Detailed exploration of active components in traditional herbal medicines such as the Neem (<em>Azadirachta indica</em>), Salai guggul (<em>Boswellia serrata</em>), Green tea (<em>Camellia sinensis</em>), Saffron (<em>Crocus sativus</em>), Turmeric (<em>Curcuma longa</em>), Mangosteen (<em>Garcinia mangostana</em>), Indian mulberry (<em>Morinda citrifolia</em>), Black cumin (<em>Nigella sativa</em>), Ashwagandha (<em>Withania somnifera</em>), and Ginger (<em>Zingiber officinale</em>) reveals their potential anti-inflammatory properties. The in-depth study of these plants provides insight into their potential applications in managing inflammatory disorders. Further research and development are necessary to substantiate these findings and translate them into clinically effective therapeutics.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101081"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute urinary retention following frequent administration of Guggulu Tiktakam Kwatha and its management - a case report","authors":"Praveen Balakrishnan,&nbsp;Abhayadev A,&nbsp;Emy S. Surendran,&nbsp;Lisha S. Raj","doi":"10.1016/j.jaim.2024.101086","DOIUrl":"10.1016/j.jaim.2024.101086","url":null,"abstract":"<div><div>A 72-year-old male patient, a diagnosed case of infective spondylodiscitis, was admitted in our hospital for severe pain in the right hip and lower back (in the lumbo-sacral region) in a non-ambulatory mode. Considering the criticality, we administered <em>Kwatha</em> in a <em>Muhurmuhu</em> (frequent administration) schedule. The initial medicines reduced pain, but not the elevated C-reactive protein (CRP). To reduce this elevated CRP, we administered <em>Amruthotharam Kwatha</em> and <em>Guggulu Tiktakam Kwatha</em> (GTK) in the dosage of 30 ml every 2 h for eight times. CRP started reducing, but we encountered an acute urinary retention as an adverse drug reaction. Naranjo Adverse Drug Reaction Probability Scale recording gave a score of eight, which shows that the AE could be probably due to administration of <em>Guggulu Tiktakam Kwatha</em> (GTK) in <em>Muhurmuhu</em> schedule. When the patient did not void urine for more than 6 hours, we did <em>Marma</em> therapy on left <em>Mootthira Kala Marma</em>. The patient voided urine within half an hour of <em>Marma</em> therapy. Clinically, after the medications, pain reduced considerably, CRP came to normal, and the patient came to an ambulatory mode. This case report shows that medicines like GTK should cautiously be administered, as it may complicate. This case report also focusses light on the fact that <em>Marma</em> therapy could be a possible mode of tackling acute conditions.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101086"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of a Chemo-Recovery Kit with Ayurvedic formulations - containing coral in managing chemotherapy adverse effects and maintaining quality of life in breast cancer patients","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Tushar Patil,&nbsp;Shweta Gujar,&nbsp;Vasanti Godse,&nbsp;Swapna Kulkarni,&nbsp;Shrinivas Datar,&nbsp;Dhananjay Deshpande,&nbsp;Nilambari Sardeshmukh,&nbsp;Sushma Bhuvad,&nbsp;Bhagyashree Sardeshmukh,&nbsp;Sandeep Chavan,&nbsp;Vidya Gupta","doi":"10.1016/j.jaim.2024.101012","DOIUrl":"10.1016/j.jaim.2024.101012","url":null,"abstract":"<div><h3>Background</h3><div>Breast cancer is one of the major concerns in women globally. Treatment for breast cancer comprises surgery, chemotherapy, hormonal therapy, targeted therapy, and palliative care. Though chemotherapy is an important component of treatment, it induces adverse effects, which are mainly caused by the inability of chemotherapeutic drugs to distinguish between dividing cancer cells and normal cells leading to increase in oxidative stress and hampered immune status.</div></div><div><h3>Objective</h3><div>To investigate the benefits of Ayurvedic medicines in breast cancer patients for managing chemotherapy adverse effects.</div></div><div><h3>Material and methods</h3><div>In this retrospective study, 27 female breast cancer patients who underwent surgery, posted for chemotherapy, and complying inclusion were included. These patients were divided into two groups. Study group of 13 patients were treated with Ayurvedic formulation - Chemo-Recovery Kit with coral [filed as a herbo-mineral kit for Indian patent (201921018273- published) and US Patent (17/609,601- published)] along with chemotherapy, while 14 patients were not provided with any additional Ayurvedic medicines and were treated with chemotherapy alone (control group).</div></div><div><h3>Results</h3><div>Out of commonly observed adverse effects, statistically significant improvement is noted in symptoms such as fatigue (p &lt; 0.0001), vomiting (p = 0.001), nausea (p = 0.003) and skin discoloration (p = 0.005) in patients treated with adjunct Ayurvedic medicines. The remaining symptoms such as constipation, stomatitis and fever were also less prominent in this group. Karnofsky score (p &lt; 0.0001) and quality of life assessed were well maintained in patients treated with Ayurvedic medicines.</div></div><div><h3>Conclusion</h3><div>Chemo-Recovery Kit with coral is highly effective in management of chemotherapy induced nausea, vomiting, fatigue and skin discoloration and thus to improve Quality of Life.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101012"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific characterization of the Siddha medicine Pavala parpam manufacturing","authors":"A.S. Ganesh Kumar ,&nbsp;Selvaraj Senthilvelan ,&nbsp;V.M. Ravichandran ,&nbsp;P. Selva Shunmugam ,&nbsp;V. Kamalanathan","doi":"10.1016/j.jaim.2024.101079","DOIUrl":"10.1016/j.jaim.2024.101079","url":null,"abstract":"<div><h3>Background</h3><div>In general, various Siddha medicine manufacturing methods are reported without comprehensive scientific quantification of the process and product at various manufacturing stages.</div></div><div><h3>Objective</h3><div>The current work aimed to study the standard manufacturing method involved in the <em>pavala parpam</em> medicine preparation and characterization.</div></div><div><h3>Materials and methods</h3><div>The raw material for the <em>pudam</em> process was prepared by purifying the <em>pavalam</em> using lemon juice and ground with <em>thelkodukku</em> (Heliotropium indicum) decoction. Raw material was taken in a sealed <em>agal</em> for the <em>pudam</em> process cow dung cakes. The process parameter of the <em>pudam</em> process was recorded. After the <em>pudam</em> process, the finished medicine was ground using <em>nannikal kalvam</em>. The <em>pavala parpam</em> was characterized using Thermogravimetry (TG), X-ray diffraction analysis (XRD), X-ray fluorescence (XRF), Energy dispersive X-ray analysis (EDAX), Fourier transforms infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and a particle size analyzer.</div></div><div><h3>Results</h3><div>The maximum temperature of 680°C during the <em>pudam</em> process was recorded at the top location of the sealed <em>agal</em>, and the holding time above 500°C was observed to be 55 min, 75 min, and 122 min at the top, inside, and bottom locations, respectively. The analytical testing of <em>pavala parpam</em> shows the presence of calcium carbide, calcium oxide, and magnesium oxide.</div></div><div><h3>Conclusion</h3><div>The pressure developed during the <em>pudam</em> process was only 25–30 mbar, and it can be assumed that the <em>pudam</em> process happens at atmospheric pressure. 1 kg of raw materials yields 920 g of <em>pavala parpam</em>. The characterization of <em>pavala parpam</em> was done using modern scientific testing methods.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101079"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective, randomized, open label, parallel group, comparative clinical trial to evaluate the safety and efficacy of combination of herbal oral capsule and rectal medication to improve gut health of type 2 diabetic patients having chronic kidney disease (CKD)","authors":"Suresh Patankar ,&nbsp;Anupama Gorde ,&nbsp;Sagar Patankar ,&nbsp;Rajesh Raje ,&nbsp;Chandu Devanpally ,&nbsp;Pranjal Ausekar ,&nbsp;Gaurav Patil ,&nbsp;Shraddha Chitale","doi":"10.1016/j.jaim.2024.100992","DOIUrl":"10.1016/j.jaim.2024.100992","url":null,"abstract":"<div><h3>Background</h3><div>Chronic kidney disease (CKD) is a major health concern globally, with more than 850 million people suffering from it. Several studies have been carried out to reduce inflammation in CKD patients; and to study the relationship between gut microbiota and inflammation.</div></div><div><h3>Objective</h3><div>The effect of herbal formulations to improve the gut flora and reduce inflammation has not been studied earlier. The study aims to evaluate effect of herbal formulation combined with standard of care (SOC) treatment compared to SOC.</div></div><div><h3>Methods</h3><div>A prospective, randomized, parallel group clinical trial was planned on 90 patients split equally into standard of care (SOC) with herbal treatment (IP) and only SOC groups. The change in the abdominal pain score, percent change in the pathogenic and non-pathogenic microbiome were the key endpoints of interest. The safety assessment was in terms of adverse events, changes in hematological and biochemical parameters.</div></div><div><h3>Results</h3><div>The demographic and other patient characteristics showed statistically non-significant differences between two groups. On day 90, the median abdominal score in SOC + IP group (2.00) was significantly lower than that of SOC group (3.00) (p = 0.002). The quality of life score improved significantly in SOC + IP group (p &lt; 0.001), unlike SOC group. There was significant reduction in pathogenic microbes in SOC + IP group; however, the reduction in non-pathogenic microbes was non-significant in this group. The adverse events (AEs) were in mild form, and the proportion of patients with AEs differed non-significantly between two groups.</div></div><div><h3>Conclusion</h3><div>The IP supplementation along with SOC significantly improved the GUT micro flora, and improved the overall quality of life of CKD patients. This treatment combination can be practiced for effective patient management.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 100992"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Ayurvedic treatment given to cancer patients in the prevention of COVID-19 – A Retrospective Cohort Study at Integrated Cancer Treatment and Research Centre, Wagholi","authors":"Sadanand Sardeshmukh,&nbsp;Vineeta Deshmukh,&nbsp;Vidya Gupta,&nbsp;Vasanti Godse,&nbsp;Shweta Gujar,&nbsp;Swapna Kulkarni,&nbsp;Sneha Dalvi,&nbsp;Nilambari Sardeshmukh,&nbsp;Bhagyashree Sardeshmukh,&nbsp;Sushama Bhuvad,&nbsp;Sandeep Chavan,&nbsp;Vinita Awalkanthe,&nbsp;Shrinivas Datar,&nbsp;Anita Shingte,&nbsp;Abhishek Salunkhe,&nbsp;Amruta Salunkhe,&nbsp;Sneha Nabar,&nbsp;Dhananjay Deshpande,&nbsp;Trupti Dafare","doi":"10.1016/j.jaim.2024.101045","DOIUrl":"10.1016/j.jaim.2024.101045","url":null,"abstract":"<div><h3>Background</h3><div>Cancer patients are considered to have a higher risk of developing severe Coronavirus Disease 2019 (COVID-19) and a higher mortality rate. Moreover, poor prognosis observed in them is associated with multiple co-morbidities. Ayurveda can prove to be effective in preventing COVID-19 as well as improving clinical outcomes against COVID-19 in cancer patients.</div></div><div><h3>Objectives</h3><div>To evaluate the effect of Ayurvedic treatments given to cancer patients as also a preventive modality against COVID-19 infections.</div></div><div><h3>Methods</h3><div>700 cancer patients were enrolled in the study. The demographic information regarding their age, sex, organs involved, stage, pre-existing comorbidities, Karnofsky score, addictions, undergoing conventional cancer treatment, type of conventional treatment, and duration of Ayurvedic cancer treatment was collected from the institutional records. These patients were interviewed telephonically or in person to obtain information related to their COVID-19 status from March 2020 to Sep 2021, which included a) whether they were affected with COVID-19 or not, b) If affected, the severity of COVID-19 symptoms, c) vaccination status, d) mortality, and e) if in contact with relative affected by COVID-19.</div></div><div><h3>Results</h3><div>The surveyed cohort had 56 years as the median age, more female patients, Karnofsky score between 80 and 100, and hypertension as well as diabetes as major co-morbidities. During the 1st and 2nd waves, 34 (4.85%) and 65 patients (10.09 %) were COVID-19 positive while 4.91 % and 11.11% of patients with addictions were covid positive, respectively, the rest remained unaffected.</div><div>There was no specific trend in % of COVID-19-positive cancer patients concerning stage, but those with stage IV undergoing conventional treatment showed increased prevalence (p &lt; 0.001). Prolonged Ayurvedic treatment exhibited a decreasing trend in % COVID-19 positive patients, which is highly significant (p &lt; 0.001). Specifically, those undergoing conventional therapy, and also received Ayurvedic treatment simultaneously for more than 3 years remained unaffected by COVID-19, which was statistically significant in both waves (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Ayurvedic treatments given to cancer patients are effective in preventing COVID-19 infections in these patients.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 2","pages":"Article 101045"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}