Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Biochemical rationale for dietary management of COVID-19 patients: Indian traditional millets as a promising integrative nutritional strategy","authors":"Vivek Ambade,&nbsp;Shilpika Bagh,&nbsp;Sibin Kandi,&nbsp;Prasanna Sanas,&nbsp;Vaibhav Sharma","doi":"10.1016/j.jaim.2026.101376","DOIUrl":"10.1016/j.jaim.2026.101376","url":null,"abstract":"<div><h3>Background</h3><div>Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), imposes a significant metabolic and nutritional burden on the human host. Viral replication requires synthesis of structural proteins (S, E, M, and N), which in turn depends on an adequate supply of amino acids. While the human body can synthesize all nucleotides, it cannot synthesize eight essential amino acids (EAAs), which must be derived from dietary intake or through catabolism of endogenous protein stores such as skeletal muscle and albumin. Despite numerous dietary advisories for COVID-19 patients, including those from international agencies, none are grounded in a biochemical analysis of viral amino acid requirements.</div></div><div><h3>Objectives</h3><div>This study aimed to determine the amino acid distribution of SARS-CoV-2 structural proteins and to identify nutritionally optimal, economically accessible staple and widely consumed foods capable of counteracting the essential amino acid burden during COVID-19.</div></div><div><h3>Materials and methods</h3><div>In this computational study, the amino acid profiling of SARS-CoV-2 structural proteins was performed using bioinformatics analysis of genomic sequences obtained from the GenBank database. The amino acid composition of commonly consumed foods was derived from the Indian Food Composition Tables (IFCT) 2017. Viral amino acid requirements were quantitatively compared with the amino acid profiles of cereals, millets, legumes, nuts, milk, and eggs to assess their suitability in meeting essential amino acid demands.</div></div><div><h3>Results</h3><div>Synthesis of SARS-CoV-2 structural proteins required all 20 amino acids. Essential amino acids constituted 42.8% of the total amino acid requirement, with branched-chain amino acids (valine, leucine, and isoleucine) accounting for approximately 23%. The nutritional load per virion ranged from 1.6% for methionine to 11.3% for leucine. Rice, wheat, maize, legumes, and even expensive nuts like almond, cashew nut, pistachio nuts and walnut were insufficient in meeting the most abundantly required EAAs. In contrast, millet-based diets, particularly combinations of pearl millet with sorghum or foxtail millet, showed superior amino acid complementarity. Cow milk closely matched overall EAA requirements, while foxtail millet supplemented with eggs provided an optimal mixed-diet option.</div></div><div><h3>Conclusion</h3><div>This study provides a biochemical rationale for dietary management of COVID-19 and identifies Indian traditional millets as a nutritionally effective and integrative dietary strategy to mitigate essential amino acid burden during SARS-CoV-2 infection.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101376"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senile lower urinary tract symptoms [LUTS] management through Ayurveda: A case series","authors":"Foram P. Joshi","doi":"10.1016/j.jaim.2026.101360","DOIUrl":"10.1016/j.jaim.2026.101360","url":null,"abstract":"<div><div>Lower urinary tract symptoms (LUTS) refer to a range of symptoms of anatomical and physiological variations of the bladder and urethra in women and also the prostate in men. This involves storage and voiding related pathologies and clinically present with urgency, nocturia, weak stream of urine, incomplete emptying of the bladder, dysuria, hesitancy, frequency, intermittency, etc. Medical and surgical management based upon core pathogeneses is under practice successfully but post-operative complications and high chances of post-operative urethral stricture are also on account. No gold standard management has been validated yet for the management of LUTS in contemporary Ayurveda clinical practice. This study refers to the Ayurvedic management of 10 clinical cases of LUTS through the 21-day protocol of 60 ml <em>Bala Taila Matra Basti</em>, and internal medicines like <em>Haritaki</em> (<em>T. chebula</em> Retz.) powder, <em>Kanchanar</em> Guggul and <em>Varunadi Kwatha</em> for 30 days and their assessment through uroflowmetry, and IPSS Score before and after the treatment. Remarkable improvement was observed in relieving the IPSS (26.97%) symptoms and post-voided residual urine volume (PVRV) (39.54%). Improvement in increasing average flow rate (Qavg), (41%), Maximum flow rate (Qmax.) (43.51%), and total voided volume (53.57%) were also observed in this study. <em>Anulomana</em> (promoting Normal motion of <em>Vata</em>) and <em>Mootrala</em> (diuresis) were the two clinical principles that helped to manage LUTS. Improved Peak flow (Qmax.), Average volume (Qavg.) and total voided volume are the key indicators of improved micturition function. Ayurveda management with <em>Bala Taila Matra Basti</em> can be considered for the management of LUTS.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101360"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring gut harmony - Role of Grahani Chikitsa in the management of irritable bowel syndrome - a case report","authors":"Vaishali N,&nbsp;Suvendu Rout,&nbsp;Vijayarajaa P","doi":"10.1016/j.jaim.2026.101386","DOIUrl":"10.1016/j.jaim.2026.101386","url":null,"abstract":"<div><div>In contemporary society, the prevalence of irregular lifestyles, particularly nocturnal habits, coupled with sub optimal dietary patterns and heightened psychological stress, has significantly contributed to gastrointestinal disturbances. Irritable Bowel Syndrome (IBS), a multi factorial disorder, is often precipitated by stressors such as depression or systemic illnesses. Conversely, IBS itself may serve as a precursor to psychological disorders, underscoring the intricate gut-brain axis interplay. A symptomatic approach to management is insufficient, rather a focus on addressing the underlying pathophysiological mechanisms is imperative for sustained gastrointestinal health and overall well-being. Epidemiological data indicate that IBS affects approximately 12%–15% of the Indian population, with a female predilection, being three times more prevalent in women than men. Ayurveda views <em>Grahani</em> as both an organ and a functional entity, where <em>Grahani Dosha</em> refers to its impaired functioning. If this dysfunction progresses, it leads to <em>Grahani Roga</em>, which is characterized by chronic gastrointestinal symptoms. A comprehensive understanding of <em>Grahani</em>, in its context as an organ, <em>Dosha</em>, and <em>Roga</em>, is necessary to systematically analyze gastrointestinal disturbances. This case study discusses a 25-year-old male with a two-year history of poor appetite, weight loss, nausea, abdominal pain, frequent bowel urges, and alternating episodes of constipation and diarrhea, along with persistent insomnia. A structured treatment protocol was implemented to strengthen the gut-brain axis and manage <em>Grahani Roga</em> through internal and external purification therapies (<em>Antar</em> and <em>Bahir Parimarjana Chikitsa</em>). Over just 10 days, significant improvements were observed in the Rome IV criteria and scales related to IBS and anxiety. The findings highlight that <em>Grahani</em>, which involves altered bowel habits and nutritional deficiencies due to malabsorption, can be classified as a syndrome that results from a complex interaction of various disorders, making it one of the <em>Ashta Mahagada</em>.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101386"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayush systems in India- understanding the Awareness, Utilization, and Out-of-Pocket Expenditure (OOPE): Insights from the 79th round of National Sample Survey (NSS)- 2022–23","authors":"Shobhit Kumar,&nbsp;Shrestha Hazra,&nbsp;Abhijit Dutta,&nbsp;Deepak Londhe,&nbsp;Raman Kaushik","doi":"10.1016/j.jaim.2026.101361","DOIUrl":"10.1016/j.jaim.2026.101361","url":null,"abstract":"<div><h3>Background</h3><div>Ayush systems form a crucial component of India's healthcare system. Despite sustained policy attention, the implementation of the National Ayush Mission scheme and progress in the sector, challenges persist in the availability and utilization of Ayush services in several States/UTs. Drawing on the National Sample Survey (79th Round, 2022–23) on Ayush, this study examines state-wise variations in awareness, usage, and out-of-pocket expenditure (OOPE) on Ayush medicines, alongside the availability of infrastructure, human resources, and financial burden.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional analysis was undertaken using NSSO 79th Round data, supplemented with information on Ayush dispensaries and registered practitioners. Population coverage per dispensary and per practitioner served as proxy indicators for infrastructure and workforce availability. States/UTs were categorized by availability levels and usage relative to the national average (496 users per 1000). Cross-tabulations and comparative categorizations were used to examine inter-state variation.</div></div><div><h3>Results</h3><div>National awareness exceeded 95%, while usage remained around 50%, with substantial variation across States/UTs. 20 States/UTs reported above-national average usage and sixteen below. Infrastructure availability varied widely, with only five States/UTs meeting high dispensary coverage and thirteen exhibiting very low coverage. Practitioner availability was similarly uneven, ranging from zero in several Northeastern States to strong density in Kerala and Maharashtra. Higher availability did not consistently correspond with higher usage. OOPE averaged ₹523 per capita annually, with significant inter-state differences, indicating non-linear associations.</div></div><div><h3>Recommendations and conclusion</h3><div>Despite widespread awareness, Ayush utilization remains uneven due to infrastructure gaps and workforce disparities. Strengthening infrastructure and human resources, improving quality of care, expanding digital systems, enhancing public financing, education and training, promoting evidence-informed communication, and reinforcing research–practice linkages are essential to improve access, utilization and financial protection.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101361"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148463029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symphytum officinale enhances fracture healing in Wistar albino rats by promoting osteogenesis in fracture callus","authors":"S. Tyagi,&nbsp;P.K. Pagaku,&nbsp;V. Shrivastava,&nbsp;D. Dey,&nbsp;A. Aryal,&nbsp;A. Bhattacharya,&nbsp;S. Rani,&nbsp;B. Garg,&nbsp;P. Khanna,&nbsp;A. Goyal,&nbsp;D. Nayak,&nbsp;R.K. Srivastava,&nbsp;A.R. Mridha,&nbsp;S. Sen","doi":"10.1016/j.jaim.2026.101344","DOIUrl":"10.1016/j.jaim.2026.101344","url":null,"abstract":"<div><h3>Background</h3><div>Symphytum officinale (SO) is a medicinal plant. This study investigated if homoeopathic doses of SO could enhance fracture healing in adult male Wistar albino rats after induction of fracture.</div></div><div><h3>Methods</h3><div>Adult male Wistar albino rats underwent open osteotomy (femur), were divided into various treatment groups and received homoeopathic doses of oral SO (mother tincture (MT) and 6C), vehicle control and standard care (control). X-ray imaging and serum analysis evaluated fracture healing. The rats were sacrificed at two time points: at 2 weeks (radiological appearance of early-soft callus) and at 5 weeks (late-hard callus). The fracture callus was evaluated with H&amp;E staining, quantitative bone morphometry, and immunohistochemistry. Bone-specific Alkaline phosphatase (B-ALP), and C-terminal telopeptide of type I collagen (CTX) were evaluated in serum using ELISA.</div></div><div><h3>Results</h3><div>X-rays showed faster formation of callus (both soft and hard callus) in groups treated with MT and 6C doses of oral SO. Quantitative bone morphometry indicated enhanced osteogenesis in both soft (early) and hard (late) callus in animals treated with MT and 6C doses of SO. Immunohistochemical evaluation of soft (early) and hard (late) callus for Col1A1 and Osteocalcin revealed supporting osteogenic mechanisms. Serum levels of B- ALP and CTX indicated osteoanabolic activity in rats treated with the MT dose of SO.</div></div><div><h3>Conclusions</h3><div>Oral administration of homoeopathic doses of Symphytum officinale (especially mother tincture dose), has the potential to enhance fracture healing in adult male Wistar albino rats.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101344"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148463140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicological evaluation of herbo-mineral formulation: Acute and sub-acute oral toxicity in rats","authors":"Mukul S. Tambe,&nbsp;Akshay M. Baheti,&nbsp;Arti G. Swami,&nbsp;Anil T. Pawar","doi":"10.1016/j.jaim.2026.101368","DOIUrl":"10.1016/j.jaim.2026.101368","url":null,"abstract":"<div><h3>Background</h3><div>Toxicity evaluation is an essential component of the preclinical safety assessment for herbal and herbo-mineral formulations intended for repeated use.</div></div><div><h3>Objectives</h3><div>The present study was undertaken to assess the acute and subacute oral toxicity of an Ayurveda-based herbo-mineral formulation (HMF) comprising <em>Tinospora cordifolia</em> (Thunb.) Miers, <em>Withania somnifera</em> (L.) Dunal, and <em>Kukkutandatvak bhasma</em> in rats.</div></div><div><h3>Methods</h3><div>An acute toxicity of a prepared HMF was conducted at a single oral dose of 2000 mg/kg in rats as per OECD guideline 423. Sub-acute toxicity of HMF was evaluated at 250, 500, and 1000 mg/kg by oral administration in rats in accordance with OECD Test Guideline 407.</div></div><div><h3>Results</h3><div>No mortality and clinical signs of toxicity were produced in rats by a single oral administration of a 2000 mg/kg dose of HMF. In the subacute toxicity study, body weight gain and food consumption patterns in the HMF-treated groups were comparable to those of the vehicle control group. Hematological and serum biochemical parameters remained within physiological limits. The relative organ weights did not differ significantly between the control and HMF-treated groups. Histopathological evaluation of the organs of HMF-treated rats revealed normal findings. No delayed or residual toxicity was observed in the satellite group.</div></div><div><h3>Conclusion</h3><div>HMF was found to be safe following a single 2000 mg/kg dose and at a 28-days repeated dose of 1000 mg/kg by the oral route in rats. The study findings support the safety of the HMF and provide a scientific basis for further preclinical and clinical development.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101368"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of measurement instruments for Ayurveda research: A systematic review protocol","authors":"M.S. Anagha,&nbsp;V.P. Ribin,&nbsp;N.K. Arun,&nbsp;T. Anju Aravind,&nbsp;Shalini Rai,&nbsp;Anand B. More","doi":"10.1016/j.jaim.2026.101357","DOIUrl":"10.1016/j.jaim.2026.101357","url":null,"abstract":"<div><div>The growing global recognition of Ayurveda, an ancient holistic system of medicine, highlights the urgent need for well-developed and validated measurement instruments to assess its core constructs and clinical concepts used in diagnosis and treatment. Although several psychometric and clinical tools have been designed to quantify these traditionally qualitative aspects, their evolution has often been marked by methodological inconsistencies and inadequate psychometric validation, limiting their acceptance and practical application in both research and clinical domains. Addressing this gap, the present systematic review aims to comprehensively identify, map, and characterize the existing measurement instruments developed or adapted for Ayurvedic constructs and concepts. It further seeks to delineate the methodological challenges encountered during their development and validation, and to suggest future directions for improving their psychometric rigor, clinical relevance, and scientific robustness to enhance their use in evidence-based Ayurvedic research. A systematic and exhaustive search will be carried out across multiple databases including PubMed, MEDLINE, Scopus, EBSCO, Cochrane Library, AYUSH Research Portal, DHARA, Shodhganga, and Google Scholar, using a combination of controlled vocabulary (such as MeSH terms) and free-text keywords integrated with Boolean operators. In addition, reference lists of selected studies and grey literature sources will be screened to ensure comprehensive coverage. Two independent reviewers will perform study screening, data extraction, and quality assessment following standardized procedures. This protocol has been registered with PROSPERO (registration number: CRD420251102044). Since this is a review protocol, definitive results are not yet available. However, the forthcoming review is expected to present an extensive overview of the current landscape of Ayurvedic measurement instruments, elucidate existing methodological and psychometric gaps, and propose strategies for their refinement. These outcomes will be instrumental in reinforcing the scientific foundation of Ayurveda, promoting methodological rigor, and fostering its integration into global healthcare systems.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101357"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Ayurveda treatment protocol in the management of prediabetes- A randomized controlled clinical trial","authors":"Suman Khanal,&nbsp;Suketha Kumari,&nbsp;Laxmikant S.D.,&nbsp;Asha","doi":"10.1016/j.jaim.2026.101392","DOIUrl":"10.1016/j.jaim.2026.101392","url":null,"abstract":"<div><h3>Background</h3><div>Prediabetes is a subject of intermediate hyperglycaemia and a risk factor for various metabolic and cardiovascular diseases, which are silent in features. Early Screening and preventive measures in terms of diet and lifestyle modification can help reverse the prediabetic stage.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy of Ayurveda-based treatment protocol in the management of prediabetes and to compare it with the standard prediabetic care.</div></div><div><h3>Materials and Methods</h3><div>A total of 40 patients meeting the criteria of HbA1C 5.7-6.4% and Indian diabetic risk Score of ≥60, with the age group of 18-70 years of either sex, participated in the study. They were randomly divided into two groups in which trial group, intervened with Integrated Ayurveda Treatment Protocol (IATP) contains <em>Triphala lauha churna</em> 3 g twice a day along with Ayurveda dietary and lifestyle intervention and control group received placebo powder 3 g twice a day for 90 days along with standard prediabetic care (SPC). The primary endpoints were changes in glycated hemoglobin (HbA1C), fasting blood glucose (FBG), postprandial blood glucose (PPBG), and secondary endpoints were lipid profile, diabetes quality of life (DQOL), and anthropometric measures.</div></div><div><h3>Results</h3><div>Study data indicate that IATP showed significant improvement in HbA1C compared to the SPC (p &lt; 0.001). IATP also showed significant improvement in FBG (p &lt; 0.001), PPBG (p = 0.0003), total cholesterol (p = 0.0004), high density lipoprotein (p = 0.003), low density lipoprotein (p = 0.01), serum triglycerides (p = 0.003), serum creatinine (p = 0.0011) and DQOL (p &lt; 0.001). Comparable outcomes were noted in weight (p = 0.24), BMI (p = 0.05), and waist-hip ratio (p = 0.06).</div></div><div><h3>Conclusion</h3><div>IATP intervention showed significant improvement in glycaemic outcomes, lipid profile compared to the SPC group. Comparable outcomes were observed in anthropometric measures.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 4","pages":"Article 101392"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Yoga on inflammatory markers and its impact on cardiovascular health and rehabilitation: A systematic review","authors":"Swati Kumari Choudhary ,&nbsp;Jyotsna Sharma ,&nbsp;Rajat Sharma ,&nbsp;Sumit Sharma ,&nbsp;Navjeet Saini ,&nbsp;Manjari Rain ,&nbsp;Neelam Dahiya ,&nbsp;Gurmeet Singh ,&nbsp;Akshay Anand","doi":"10.1016/j.jaim.2026.101326","DOIUrl":"10.1016/j.jaim.2026.101326","url":null,"abstract":"&lt;div&gt;&lt;div&gt;One of the main mechanisms in cardiovascular disease (CVD) development is inflammation. Increased risk of CVD has been linked to elevated levels of inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α). According to recent estimates, CVD, which includes ischemic heart disease and stroke, accounted for 19.8 million fatalities globally, or around 32% of all deaths, with an age-standardized death rate of 235 per 100,000. Over 523 million individuals worldwide are affected by prevalence, which is fuelled by risk factors like diabetes and hypertension as well as aging populations. According to the Global Burden of Disease report, low- and middle-income areas continue to have significant burdens.&lt;/div&gt;&lt;div&gt;In the management of CVD, yoga, a mind-body intervention, has been proven to have anti-inflammatory effects. This review intends to investigate the association between heart health and inflammatory indicators, as well as the function of yoga in treating CVD. Atherosclerosis development and cardiovascular disease (CVD) events are driven by chronic inflammation, and severe unfavourable cardiac outcomes in patients with coronary artery disease (CAD) are independently predicted by higher levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α). Even though there are more than 200 million cases of CAD worldwide, traditional cardiac rehabilitation results in poor adherence and a chronic inflammatory burden following percutaneous coronary intervention (PCI). This highlights the need for supplemental, non-pharmacological therapies like yoga that alter autonomic regulation and cytokine networks and its role in rehabilitation.&lt;/div&gt;&lt;div&gt;This systematic review synthesizes unique evidence on yoga's effects on inflammatory markers and their mechanistic links to cardiovascular health improvements in adults with or at risk for CVD.&lt;/div&gt;&lt;div&gt;Comprehensive searches across PubMed, Cochrane Library, Web of Science, Scopus, and Embase (2000-2026) employed MeSH terms and keywords including (\"yoga\" OR \"hatha yoga\" OR pranayama OR \"yoga therapy\") AND (\"inflammatory markers\" OR CRP OR \"hs-CRP\" OR IL-6 OR TNF-α OR cytokine∗) AND (\"cardiovascular diseases\" OR CAD OR \"myocardial infarction\" OR \"endothelial function\" OR \"cardiac rehabilitation\"), restricted to randomised controlled trials (RCTs), humans, and English-language publications. PRISMA guidelines directed study selection, data extraction (mean differences, standardized mean differences for biomarkers like CRP, IL-6, TNF-α, adiponectin), and risk-of-bias assessment via Cochrane RoB 2 tool.&lt;/div&gt;&lt;div&gt;Yoga interventions consistently and reproducibly attenuate systemic inflammation in CVD populations, offering mechanistic support for enhanced cardiovascular risk reduction beyond standard care. These findings advocate standardized yoga protocols relevant for secondary prevention guidelines, warranting large-","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101326"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective, randomized, controlled, open-label blinded end point clinical study of Ayulite in comparison with vitamin E for efficacy and safety in patients with non-alcoholic fatty liver disease","authors":"Vyankatesh Shivane ,&nbsp;Sanjay Tamoli ,&nbsp;Amol Hartalkar ,&nbsp;Kamlakar Gajre ,&nbsp;Hema Shah ,&nbsp;Ameet Mandot ,&nbsp;Sheetal Padalkar ,&nbsp;Rohit Barnabas ,&nbsp;Swapnali Padalkar","doi":"10.1016/j.jaim.2026.101341","DOIUrl":"10.1016/j.jaim.2026.101341","url":null,"abstract":"<div><h3>Objective</h3><div>The incidence of non-alcoholic fatty liver disease is increasing globally including India and the USA. Currently, vitamin E and pioglitazone are the only recommended drug treatments available. We aim to study the safety and efficacy of Ayulite a polyherbal capsule formulation containing combination of 11 herbs in patients with non-alcoholic fatty liver disease in comparison with Vitamin E.</div></div><div><h3>Methods</h3><div>Prospective, randomized, open-label blinded end point controlled clinical study for efficacy and safety of Ayulite in patients with non-alcoholic fatty liver disease (NAFLD) compared to Vitamin E supplements. Ultrasonography was used to grade fatty liver and vibration-controlled transient elastography was used to assess both the hepatic steatosis and fibrosis.</div></div><div><h3>Results</h3><div>A total of 67 patients were randomized (Ayulite group n = 33, vitamin E group n = 34), of which 61 patients were included for final analysis. Mean age of patients in the ayulite group and vitamin E group was 43.69 ± 9.89 years and 44.62 ± 10.42 years respectively with no other statistical difference in demographic characteristics between the groups. 4/29 in Ayulite [grade 1 fatty liver (n = 3), grade 2 (n = 1) and 7/32 patients in vitamin E (grade 1 fatty liver(n = 4), grade 2 fatty liver(n = 3)] completely recovered after 90 days of treatment with no statistical difference between the groups. Controlled Attenuation Parameter increased in Ayulite(p 0.002), decreased Ayulite (p NS). There were 8 and 10 adverse events were noted in ayulite and vitamin E group respectively.</div></div><div><h3>Conclusion</h3><div>The efficacy and safety of Ayulite was comparable to vitamin E which makes it a potential herbal option in the management of patients with grade 1 and 2 fatty liver.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101341"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147995306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}