Journal of Innovations in Applied Pharmaceutical Science (JIAPS)最新文献

{"title":"Formulation and evaluation of preungual delivery system containing eugenol for the treatment of onychomycosis","authors":"Mini Elias, Flowerlet Mathew, Gourisree T, Anila Rajan, Ashly Davis","doi":"10.37022/jiaps.v8i3-s.531","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.531","url":null,"abstract":"The purpose of the study was to formulate a Preungual delivery system containing Eugenol for the treatment of Onychomycosis. And to find out the best polymer concentration, concentration of penetration enhancers and to carry out the anti-fungal testing on the best formulation obtained. The in vitro diffusion studies were carried out in Franz diffusion cell using phosphate buffer pH 7.4 and methanol as medium, whereas the permeation studies were carried out using hooves membrane. The percentage of cumulative drug released was determined by a UV spectrophotometer. The formulation containing 10% w/v of ethyl cellulose along with 2.5%w/v thioglycolic acid and 2.5 %v/v of dimethyl sulfoxide showed a good release. Eugenol nail lacquer's sensitivity against Candida albicans was determined by measuring the zone of inhibition by comparing it with a standard drug. The formulation showed a zero-order release pattern and the Higuchi model for the mechanism of release.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"418 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139204042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity profile of chemotherapy regimens for multiple myeloma patients using CTCAE Criteria","authors":"Antony V R, Arpith Antony, Helan Kurian, Jeeva Ann Jiju Jiju, Timy Thomas, Jithin Sunny, Suja Abraham","doi":"10.37022/jiaps.v8i3-s.506","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.506","url":null,"abstract":"Background: Multiple myeloma (MM) is a hematological malignancy of B-cells of plasma cells. The increasing incidence of MM and because of the scarcity of Indian studies on this topic, a detailed study regarding the toxicity profile of chemotherapy regimens for multiple myeloma patients using CTCAE criteria is necessary. Aim: The aim of the study is to investigate the toxicity profile of various chemotherapy regimens in MM patients, specifically using the CTCAE criteria.Methodology: The study is retrospective and clinically based, focusing on MM patients who received different chemotherapy regimens (CyBorD, VD, VRD, TD, and RD) at the Caritas Cancer Institute in Kottayam between 2015 and 2019. Patients meeting specific inclusion and exclusion criteria were selected. Toxicity profiles were analyzed at two-time points: after 4 cycles of treatment (4 months) and at the end of therapy. Results: The study involved 87 patients with a mean age of 64 ± 11.8 years. The majority of patients (83.9%) had MM for less than 2 years. A total of 575 adverse events were reported and categorized based on the CTCAE criteria: 43.5% were Grade 1 (mild), 34.8% were Grade 2 (moderate), 19.1% were Grade 3 (severe), and 2.6% were Grade 4 (life-threatening). The most commonly reported toxicities included anemia, thrombocytopenia, renal failure, and peripheral neuropathy Conclusion: The study's findings suggest that while toxicities were common among MM patients receiving chemotherapy, the majority were of Grade 1 (mild) severity. Very few cases reached Grade 4, which indicates life-threatening consequences. This information can help healthcare professionals and patients make informed decisions regarding the choice of chemotherapy regimens for MM treatment.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139208000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of topical gels incorporated with solid dispersions of an antiinflammatory drug","authors":"Sethu Lekshmi, Therase Jose, Manju Maria Mathews, B. R","doi":"10.37022/jiaps.v8i3-s.536","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.536","url":null,"abstract":"Formulation and development of a most effective product from poorly soluble drugs is one of the most challenging tasks in pharmaceutical industries. Solid dispersion is an efficient solubility enhancement method to overcome the solubility problem. The aim of this study was to formulate topical gels incorporated with solid dispersion of Aceclofenac to enhance permeability through the skin. Aceclofenac solid dispersions were prepared using suitable hydrophilic carriers to increase its aqueous solubility. In this study, solid dispersions of Aceclofenac were prepared by solvent evaporation and co-grinding method with two different hydrophilic carriers such as polyvinyl pyrrolidone (PVPk-30), and HPMC E15 LV. These were used in the ratio of (drug: carrier) 1: 1, 1:2 & 1:3 respectively. Evaluation parameters for formulation optimization were drug content, percentage practical yield, DSC, , in-vitro dissolution studies & FTIR. The optimized SD (F3) solid dispersion is incorporated in topical gels of different concentrations prepared by using two gelling agents such as Carbopol 934 and HPMC K100M. From the results of in-vitro dissolution studies it was found that formulation F3 containing PVP k30 (1 : 3 ratio of drug: PVP k30) shows a higher dissolution rate compared with other formulations and pure drug. Optimized solid dispersion was incorporated into topical gels prepared by using two gelling agents in different concentrations. From the stability data obtained, no significant changes in physical appearance, viscosity, pH, and drug contents were seen. The present research work could be concluded as a successful production of topical gels incorporated with Aceclofenac solid dispersion. Improvement in aqueous solubility and thereby greater skin permeation is expected","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"366 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139203067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro anti-bacterial screening of drynariya quercifolia","authors":"Ashna T, L. M. Joy, Siyara Antony, Sindu T J, Sheeba Mol P, Shiji T S, Soumya K George","doi":"10.37022/jiaps.v8i3-s.537","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.537","url":null,"abstract":"Purpose: To make scientific validation with antibacterial activity of ethnomedical fern Drynaria quercifolia Method and results: The various rhizome extracts were prepared with different solvents   like benzene, Ethyl acetate, chloroform, Ethanol, water and their percentage yield were identified as 7,3,2.3,3.1&6.4 respectively and analytical parameters and histological studies undergone with this fern. Various preliminary phytoconstituent screening was carried out and the ethyl acetate extract showed the maximum presence of active constituents. Bacterial activity was screened with (gram-positive and gram-negative bacteria) and the zone of inhibition was measured. Compared with standard Ampicillin (250µgm) and ethyl acetate was more active and most effective against Bacillus subtilis. Conclusion: In the antibacterial study ethyl acetate extract shows good antibacterial activity even in microgram quantities. It is found to be very effective against Bacillus subtilis. From the studies we have concluded that Drynaria quercifolia can be effectively used as an anti-bacterial agent.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"59 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139198364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient microwave synthesis of coumarin derivatives with evaluation of their antioxidant and anti-inflammatory properties","authors":"Anziya P A, S. T S, A. K, Anjali Krishna, Sini Baby, Divine P Daniel","doi":"10.37022/jiaps.v8i3-s.523","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.523","url":null,"abstract":"Microwave radiation, an electromagnetic radiation, is used as a source of heating in organic synthesis. Coumarin, a benzopyrone derivative, shows various pharmacological activities such as anticoagulant, antimicrobial, analgesic, anti-inflammatory. The prime objective was to compare the synthesis of some coumarin derivatives by microwave assisted methods. Two different coumarin derivatives were synthesized and evaluated for their anti-inflammatory activity and anti-oxidant activity. 3-Acetylcoumarin (3-acetyl-2H-Chromen-2- one) was synthesized by reaction with salicylaldehyde and ethyl acetoacetate in presence of piperidine and the 3-acetyl-6-bromocoumarin (3-acetyl-6-bromo-2H-chromen-2-one) was synthesized by using 5-bromo-salicyladehyde. The synthesized compounds were characterized by MP, TLC, IR and NMR. The antioxidant activity of the compounds was done by reducing power by ferric chloride, nitric oxide and hydrogen peroxide scavenging method. The anti-inflammatory activity of the compounds was done by protein denaturation using BSA method. Out of the two compounds synthesized, bromine-substituted acetyl coumarin showed more anti-oxidant and anti-inflammatory activity when compared to standard.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"368 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139205575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of physical functioning in rheumatoid arthritis patients after rituximab therapy using health assessment questionnaire-disability index","authors":"Maria Joy Anna, Akshara Shaji, Shaniya Mathew, Suja Abraham","doi":"10.37022/jiaps.v8i3-s.505","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.505","url":null,"abstract":"The most frequently used instrument for measuring self-reported physical function in rheumatoid arthritis is the health assessment questionnaire – disability index. The objective of this study was to assess the effects of treatment with rituximab on patient-reported outcomes in severe rheumatoid arthritis patients. Rituximab was initiated in RA-diagnosed patients who experienced treatment failure or decreased response on the administration of conventional disease-modifying anti-rheumatic drugs. Treatment response after 1g of rituximab infusion was assessed at <6 months and > 6 months follow-up period using patient-reported outcome measure tools and laboratory investigations. Functional ability was evaluated using a questionnaire and the overall disability index was calculated. It was found that all patients achieved minimum clinically important difference(>0.2) from baseline HAQ value within 6 months of rituximab. Assessment of the functional ability demonstrated that the majority of the patients experienced significant improvement in all domains of HAQ-DI after rituximab administration. Patient global assessment shared a moderate correlation with almost all domains of HAQ-DI. Physical function as measured by HAQ-DI  showed clinically meaningful improvement within 1 year of rituximab therapy. It has proven to be a safer and more effective treatment option when compared to conventional disease-modifying antirheumatic drugs and has also helped in achieving better responses at a faster pace.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"126 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139197249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of herbal aftershave gel","authors":"Celu Mariya Francis, Riya George, Anaswara Sankar, Ancy I J, Manju Maria Mathews, B. R","doi":"10.37022/jiaps.v8i3-s.521","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.521","url":null,"abstract":"Aftershave gels are cosmetic products that may often contain alcohol which is an antiseptic agent to prevent infection of cuts, as well as to act as an astringent to reduce skin irritation. However, alcohol-based aftershave gels may be prone to cause burns or irritations. The main aim of the present study is to formulate and evaluate aftershave gel with reduced alcohol content using Hemigraphis colorata extract. The Hemigraphis colorata plant possesses wound healing and anti-inflammatory actions. Ethanol was used as solvent for the extraction in our present study.  The gel formulation F0 was made according to the conventional formula having 50% alcohol content. The second formulation F1 was the one that contains three fourth of the alcohol of the above formulation. The final gel F2 was the one with three-fourths of the quantity of alcohol mentioned in the conventional formula and having Hemigraphis colorata extract in the concentration 50mg/ml. Gels were evaluated for pH, viscosity, and anti-bacterial properties. From the studies conducted it was concluded that the formulation used Hemigraphis colorata extracts showed better antimicrobial activity than the conventional “alcohol-only” formulation. So, from the study it can be concluded that plant would be a promising candidate to be used in an aftershave preparation, provided it exhibits astringent activity also.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139199473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of embelin from embeliaribes berries for the development of topical anti–inflammatory preparation","authors":"B. R, Maria S Padathil, Hanna Parveen, Dona Merin Joy, Shahana Majeed, Joycymol S, D. Sen","doi":"10.37022/jiaps.v8i3-s.507","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.507","url":null,"abstract":"Purpose: Embelin is a natural benzoquinone compound, isolated from Embeliaribes berries, known extensively for its anti-inflammatory properties. Due to its hydrophobic nature, it was less explored for topical preparation. Therefore, the purpose of this study was to explore the potential of embelin as an anti-inflammatory agent for topical preparations as well as assess its potential to replace synthetic drugs, which can be resistant to bacterial strains. A topical preparation with embelin would be potentially more effective as well as safer than synthetic drugs. Method: Embelin has been converted into its potassium salt, and a cream was developed, which was then subjected to physiochemical evaluation. The isolated Embelin and Embelin Potassium salts were characterised by various spectral analysis. The in vitro anti-inflammatory activity was determined by the heat-induced hemolysis and albumin denaturation. Docking scores of embelin and diclofenac were compared and the drug content per gram of cream was estimated. Result: The UV spectral absorption peak of Embelin  was determined to be at 274 nm, while that of the potassium salt of Embelin was at 515 nm.. The IR  bands were found at 1328.951cm-1,361.74 cm-1, 1616.35 cm -1,1616.35 cm -1 ,1452.4 cm -1, 748.28 cm -1  and 2947.23 cm -1  respectively due to phenolic OH bending, C=O stretching, aromatic ring bending, methylene bending and methyl stretching  . The IR spectra of Embelin potassium salt exhibited similar pattern as that of Embelin but with shifted band due to presence of potassium salt. Heat-induced hemolysis  using diclofenac as standard and embelin potassium salt as test showed  98.01% inhibition and 92% inhibition, respectively, at50µg/ml. The  binding affinity of diclofenac was determined to be -4.9, while the binding affinity of embelin was -5.7, indicating a higher affinity for embelin. Lastly, the drug content per gram of cream was found to be 95%, indicating the amount of active drug (embelin or embelin potassium salt) present in the cream formulation. Conclusion: Embelin was isolated from Embeliaribes berries and formulated into a herbal cream. The in-vitro studies conducted on the cream showed that it has a significant effect on inflammation . However, in–vivo studies are required for the prepared topical cream to confirm its effectiveness.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139202602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of buccal film of an antihypertensive drug","authors":"Ashinaa Benedict, Irin Rose Paul, Manju Maria Mathews, B. R","doi":"10.37022/jiaps.v8i3-s.528","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.528","url":null,"abstract":"The aim of the study was to formulate and evaluate Losartan potassium buccal films, an angiotensin receptor blocker and is used to treat hypertension. Losartan potassium is having less bioavailability (33%), so the buccal films are expected to increase the bioavailability by avoiding hepatic metabolism. Ten formulations of buccal films were prepared by solvent casting method using HPMC K15 M as the main film-forming polymer in various proportions with various co-polymers such as Eudragit RL. 100, Carbopol 940, Ethyl cellulose. Physicochemical characteristics,in vitro buccal permeation, in vitro release study and residence time were evaluated. In vitro studies revealed that the release rate of Losartan potassium was higher for films containing HPMC K15 M and Eudragit RL100 in 3:1 ratio. The result of stability study indicated that no significant changes have occurredduring the period of study.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"140 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139204452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment and management of rheumatoidarthritis","authors":"Hari Krishna K, Meghana B, Mercia Rani G, Anitha K, Jagadeesh A, Jalaiah M","doi":"10.37022/jiaps.v8i3.515","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3.515","url":null,"abstract":"Rheumatoid arthritis is an autoimmune inflammatory disease characterized mostly by synovitis, which is frequently Clinical manifestations include fever, malaise, edema, pain, and stiffness in several joints are followed with extra-articular organ involvement, such as interstitial pneumonia. After the initial stage, joint degradation progresses swiftly, and once the afflicted areas' deformed joints are obvious, physical dysfunction that cannot be reversed begins to occur. Thus, precise diagnosis and Treatment is required from the moment the problem first appears. While anti-inflammatory drugs and glucocorticoids were used as palliative care, disease-modifying anti-rheumatic drugs (DMARDs) are currently used to slow down and control the advancement of sickness and immunological diseases. By maintaining remission, these drugs have also been shown to halt the advancement of joint degradation and physical disability over a prolonged period of time. Precision medicine, safer and more effective treatment techniques targeted at drug holidays or cures, and therapeutic strategies are some of the future developments in medicine.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139279487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}