Formulation and evaluation of preungual delivery system containing eugenol for the treatment of onychomycosis

Abstract

The purpose of the study was to formulate a Preungual delivery system containing Eugenol for the treatment of Onychomycosis. And to find out the best polymer concentration, concentration of penetration enhancers and to carry out the anti-fungal testing on the best formulation obtained. The in vitro diffusion studies were carried out in Franz diffusion cell using phosphate buffer pH 7.4 and methanol as medium, whereas the permeation studies were carried out using hooves membrane. The percentage of cumulative drug released was determined by a UV spectrophotometer. The formulation containing 10% w/v of ethyl cellulose along with 2.5%w/v thioglycolic acid and 2.5 %v/v of dimethyl sulfoxide showed a good release. Eugenol nail lacquer's sensitivity against Candida albicans was determined by measuring the zone of inhibition by comparing it with a standard drug. The formulation showed a zero-order release pattern and the Higuchi model for the mechanism of release.