Journal of Innovations in Applied Pharmaceutical Science (JIAPS)最新文献

{"title":"Overview of ingredients in media formulation for recombinant protein production","authors":"Venkata Sri Krishna Kona, Deepthi Sri Kanigiri, Lekha Arrolla, Azharuddin Mohammed","doi":"10.37022/jiaps.v8i2.467","DOIUrl":"https://doi.org/10.37022/jiaps.v8i2.467","url":null,"abstract":"Chemically defined media (CD) have been used in the production of a wide variety of therapies, including growth factors, antibody fragments, and Fc-fusion proteins. However, commercial fermentation with complex ingredients may exhibit variable performance, which can impair product output and quality. In this context, employing CD medium for commercial fermentation becomes a viable option. In spite of the fact that CD medium is often associated with sluggish growth and/or poor productivity, recent research has demonstrated that growth in CD medium may attain a growth profile and protein titer that are comparable to those of its complex medium equivalent. In the process of producing recombinant proteins by fermentation, specified media are particularly useful in cases in which the auxotrophic phenotype of the plasmid being selected for is the driving selection pressure. Fermentation processes are heavily dependent on the development of superior strains through mutagenesis and random screening procedures, as well as the optimization of the environment to which an organism is exposed.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"188 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139352546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Pharmacovigilance: Unleashing the Potential of Generative AI in Drug Safety Monitoring","authors":"J. Praveen","doi":"10.37022/jiaps.v8i2.464","DOIUrl":"https://doi.org/10.37022/jiaps.v8i2.464","url":null,"abstract":"Pharmacovigilance plays a crucial role in ensuring drug safety and promoting patient well-being throughout the life cycle of medicinal products. However, this field faces several challenges, including underreporting of adverse events, data quality issues, and the complexity of signal detection in large datasets. To address these challenges and enhance drug safety monitoring, there is a growing interest in harnessing the potential of generative artificial intelligence (AI) techniques. This article explores the applications and implications of generative AI in pharmacovigilance. It provides an overview of popular generative models and their working principles, highlighting their ability to analyse drug databases, medical literature, and real-world data sources to identify drug-drug interactions, adverse events, and potential safety signals. Moreover, it emphasizes the importance of human validation and expert oversight in interpreting and acting on the insights generated by generative AI algorithms. The integration of generative AI with traditional pharmacovigilance methods creates a synergistic approach, combining the computational power of AI with human expertise. This integration can lead to improved signal detection, efficient case report generation, proactive risk assessment, and optimized resource allocation. Additionally, the article addresses challenges related to data quality, interpretability, and model validation in generative AI applications, emphasizing the need for standardized protocols and collaborative efforts among stakeholders. Overall, the potential of generative AI in pharmacovigilance is vast. By leveraging its capabilities, we can enhance drug safety monitoring, facilitate early detection of adverse events, and improve patient outcomes. However, it is crucial to address ethical considerations, ensure data privacy, and maintain human oversight to foster responsible and effective implementation of generative AI in pharmacovigilance practices.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132227416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug utilization patterns in pediatric population in tertiary care hospital – an observational study","authors":"Anand karunakar Raju M.S","doi":"10.37022/jiaps.v8i2.458","DOIUrl":"https://doi.org/10.37022/jiaps.v8i2.458","url":null,"abstract":"Objective: This observational study aimed to investigate the drug utilization patterns in the pediatric population at a tertiary care hospital. Methodology: The structured questionnaire was specially designed including demographic profiles, illness history, prescription regimen of pediatric group patients. Data were collected from medical records and prescriptions of pediatric patients who visited the hospital from (starting date) and (end date). The study analyzed the diagnosed condition and medication usage trends among recruited pediatric patients. Results: A total of 320 prescriptions (75% OPD and 18% IPD) of children visited in pediatric department were analyzed; with an age group of between 0 to 1 year (42%) and 1 to 2 year (32%). Among 320 participants, males were (51.2%) and females were (48.8%). The study observed the significant uses of drugs prescribed for fever (52%), acute diarrhea (48%), respiratory diseases (24.5%), gastrointestinal disorders (17.3%), and infectious diseases (15.6%). Most commonly prescribed drugs were paracetamol syrup (52%), phenylephrine (48%), zinc (41%), oral rehydration solution (44%), vitamin (46%), levocetirizine (25%), and antibiotics (34%). Most widely prescribed antibiotic group was Cephalosporins. Other prescribed medicines were domperidone, ondansetron, diazepam, etc. Conclusion: The study provided valuable insights into the drug utilization patterns, including commonly prescribing medications, adherence to guidelines and potential areas for improvement in pediatric healthcare.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131114150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Neuroprotective Activity of Chrysin Nanoparticles Using Scopalamine Induced Neuroinflammation in the Rat Model of Alzheimer’s Disease","authors":"Sirigiri Venkat Karthik, C. V, S. S","doi":"10.37022/jiaps.v8i2.452","DOIUrl":"https://doi.org/10.37022/jiaps.v8i2.452","url":null,"abstract":"Background: scopolamine induced neuroinflammation limits its long-term clinical use. Several agents/strategies were attempted to prevent scopolamine neuroinflammatory but were not found suitable for clinical use. \u0000Objective: To investigate the neuroprotective activity of chrysin nanoparticle on scopolamine induced neuroinflammation. \u0000Material and Method: Male Albino wistarrats (180- 230 grms) were evenly divided into 5 groups. Group I&II served as control (distilled  water  10ml/kg) and diseases control (scopolamine) 100mg/kg per os treated for 4 weeks, group III served as standard group which received Donepezil (1.5mg/kg) on ,while group IV and V are simultaneously treated with (50mg/kg and 100 mg/kg) orally with chrysin nanoparticle up to 4 weeks. On 29 and 30 day behavioral parameters and brain were isolated for biochemical parameters at the same time rat brains were used for histological studies. \u0000Results: Treatment of scopolamine caused neuroinflammation as the evidence by marked elevation in AchE, GSH, catalase, super oxide Dismutase, Elevated plus maze,Y-maze and Open field test. SLN chrysin decrease in AchE, catalase, super oxide dismutase, GSH time respectively. SLN chrysin increase activities of SOD, crossing, Rearing, Grooming. Histopathological changes also showed the protective nature SLN chrysin induced neuroinflammation","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120984368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of impact of structured education regarding COVID – 19 among higher secondary school children among selected schools of Kalaburagi City","authors":"A. Jose, V. A, Anith Rajeev, Amal Raj B S, V. Immanuel","doi":"10.37022/jiaps.v8i1.431","DOIUrl":"https://doi.org/10.37022/jiaps.v8i1.431","url":null,"abstract":"Background: The Coronavirus disease-2019 (COVID-19) is considered as an emerging respiratory disease that is highly infectious, and was detected in December 2019 in Wuhan, China. According to WHO, Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases. Understanding people’s perceptions of disease will provide tools to improve strategies to limit its transmission. This study aims to assess the knowledge, attitude and practices (KAP) associated with the disease among higher secondary school students. Objectives: The primary objective was to assess the knowledge, attitude and practices regarding COVID-19. The secondary objective was to improve and compare the knowledge, attitude and practices regarding COVID-19 among the school children. Materials and Methods: A community based prospective educational study was conducted among higher secondary school children of randomly selected schools in Kalaburagi city. All the selected students in the study were provided with a data collection form and assent form including self-structured questionnaires. After pre-test all the students were educated regarding COVID-19 by means of PowerPoint presentations, videos and information- leaflets on COVID-19. Post-test has been conducted after a gap of 14 days of education by means of same questionnaires. Data were collected and entered into excel and results were analyzed. Pre-test and post-test intervention data were compared using student t- test. Result: A statistically significant difference between secondary school students’ knowledge, attitudes, and practices before and after educational intervention. In the post-test, all 220 students had a good knowledge (95.7%), attitude (94.2%), and practice (92.5%) level with a very highly statistical significance which improved after structured education. Conclusion: The findings have revealed that secondary school students' knowledge, attitude, and practice have been improved after the structured education by clinical pharmacist.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128050010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of immediate drug release dosage forms","authors":"Dhanakishore B, V. M, Naidu Narapusetty","doi":"10.37022/jiaps.v8i1.423","DOIUrl":"https://doi.org/10.37022/jiaps.v8i1.423","url":null,"abstract":"Tablets are currently the most widely used dosage form due to their ease of self-administration, compactness, and simple production. In many situations, rapid action is necessary rather than conventional therapy. Immediate release dosage forms have become an alternative to traditional oral dose forms in order to address these shortcomings. Immediately after administration, immediate medication release dose forms dissolve more quickly. Super disintegrants such carboxymethylcellulose (Croscarmellose), sodium starch glycolate (Primogel, Explotab), cross-linked polyvinylpyrrolidone (Polyplasdone), and others are employed as the fundamental method in the manufacture of tablets. After being administered to the stomach, these powerful disintegrants instantly dissolve tablets. In this area, parenteral dosage forms and instant release liquid dosage forms have both been introduced for the treatment of patients. It is possible to administer suspensions in liquid dose form using common dispersion agents as hydroxypropyl methylcellulose, AOT (dioctyl sulfosuccinate), etc. Many medications, including neuroleptics, cardiovascular medications, analgesics, antihistamines, and other medications, can be thought of as candidates for this dose form as a result of the advent of immediate release therapy. Pharmaceutical companies frequently create a certain medication entity in a new and improved dosage form as the drug entity's patent life is about to expire. While providing its patient group with a more practical dosage form or dosing schedule, a new dosage form enables a producer to extend market exclusivity.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122820432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on different kinds of analytical methods are performed for the analysis of food preservatives in food","authors":"Anil Kumar Tallam, A. Sahithi, Mohana Vamsi Nuli","doi":"10.37022/jiaps.v8i1.414","DOIUrl":"https://doi.org/10.37022/jiaps.v8i1.414","url":null,"abstract":"The onslaught of pathogens (disease-causing microbes) like bacteria and mold is responsible for the majority of cases of food deterioration. The various techniques for food preservation that have been developed are all intended to lessen or completely get rid of harmful ingredients. The term \"food preservation\" refers to methods for preserving food. Food preservative improves human health by eradicating or restricting the growth of bacteria and organisms responsible for food deterioration. There has been an increase in recent decades in the consumption of foods with high preservative content. By using several analytical techniques, including Uv-Visible, Calorimetry, HPLC, GC, LCMS, and Electrophoresis, the proposed methods were employed to identify various preservatives in a variety of food products.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"222 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134433232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhydra flutuans lour with its pharmacological application: a review","authors":"M. P, D. P, R. R, P. S, Rajeswari G, Swathi Krishna K","doi":"10.37022/jiaps.v7i3.407","DOIUrl":"https://doi.org/10.37022/jiaps.v7i3.407","url":null,"abstract":"Enhydra Fluctuans Lour a medicinal plant commonly known as halencha belonging to family asteraceae. It played an important role since ancient times in treating various kinds of diseases. It enlarging great important for its therapeutic potential. Enhydra Fluctuans is one such plant which is semiaquatic herbaceous vegetable plant with serrate leaves which is available abundantly in India especially in the North Estern states. It has immense potential as medicinal plant and also has many benefiacial effect. The leaves are slightly bitter, cure inflammation, skin diseases, laxatives, bronchitis, leucoderma, billiousness and good in small pox. It also reported having anticancer, antioxidant, antidiabetic, antidiarrheal, hepatoprotective even neuropharmaco-logical effect. These acivities can be attributed mainly to presence of phytochemicals such as flavonoid, alkaloid, saponins, tannins, phenols, and carbohydrates and nutritional value including βcarotene, enhydrin, and so on. This review aims at compling the potential benefits of Enhydra Fluctuans Lour based on its pharmacological activity.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130883024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation & evaluation of cyclodextrin complexed tablets by enhancing the dissolution rate","authors":"Gowtham Mandadapu, Prachetha Kolli, Venkata Gopaiah Kurra","doi":"10.37022/jiaps.v7i3.375","DOIUrl":"https://doi.org/10.37022/jiaps.v7i3.375","url":null,"abstract":"In the present work, studies design, formulation development and evaluation of immediate release tablets of Lercanidipine inclusion complex with a view to improve its aqueous solubility, dissolution rate and oral bioavailability.The inclusion complexes of Lercanidipine were prepared with β-cyclodextrin by physical mixture, Kneading method and solvent evaporation method. The complexes were prepared in different molar ratios of drug and β-cyclodextrin namely 1:1M, 1:2M with β-cyclodextrin.The phase solubility diagram for the complex formation between Lercanidipine and β-cyclodextrin in water are AL type. Phase solubility diagram of Lercanidipine with β-cyclodextrin illustrate the solubility enhancement capacity of cyclodextrin.  The aqueous solubility of Lercanidipine increased linearly (R2=0.989) as the function of β-cyclodextrin concentration. The stability constant “Kc” was found to be 164.557M-1.Invitro dissolution studies for pure drug and inclusion complexes and prepared tablets were carried out in 900 ml of 0.1N HCL using USP II paddle type dissolution apparatus.It is evident that the complex and tablets prepared were exhibited a faster dissolution when compared to pure drug dissolution data.A marked improvement in the dissolution rates observed with LK2 prepared by Kneading method. The higher dissolution rates observed with inclusion complexes and tablets prepared by Kneading may be due to better interaction of drug β- cyclodextrin. The prepared complexes were characterized by FT-IR Studies.The inclusion complex of Lercanidipinei.e.LK2 complex and F6 tablets containing LK2 complex were subjected to short-term stability studies by storing them at room temperature and at 400C and relative Humidity of 75%RH. The samples were analyzed at an interval of one week, three weeks and six weeks for their physical appearance, drug content values and dissolution profiles. No appreciable changes observed with the above parameters.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121922692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automation in pharmacovigilance: artificial intelligence and machine learning for patient safety","authors":"C. V., D. P, Susmita A, S. P, Ramya Ch, Chandini K","doi":"10.37022/jiaps.v7i3.374","DOIUrl":"https://doi.org/10.37022/jiaps.v7i3.374","url":null,"abstract":"Automation promises to be a game- change for pharmacovigilance decreasing the cost of case reporting and improving data quality to truly add value, including signal detection in drug safety. Pharmacovigilance analytic and benefit – risk assessment.Technology advances are playing a major role in pharmaceutical PV strategy updates. For example more companies are looking towards cloud- based solutions, mobile applications, robotic automation, artificial intelligence and big data analytics as a vital part of clinical safety and regulatory operations in the pharmaceutical industry. Applying innovative technology automation tools and processes to PV strategies is now a critical requirement for managing the safety of pharmaceutical products. The role of artificial intelligence and machine learning in pharmacovigilance can enhance the productivity in identification, detection, management and reporting of ADRs. The main objective ofArtificial intelligence is meant to challenges to implementing intelligent automatic solutions include finding / having appropriate training data for machine learning models and the need for harmonised regulatory guidance. AI can analyse and interpret data at lightning speed, never gets tried or sick and can simply work by 24/7. Thousands of adverse effects are processed every month by ICSR in PV that incudes native automation and standalone technologies like AI and ML that reduce the manual effort.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122364191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}