Journal of Innovations in Applied Pharmaceutical Science (JIAPS)最新文献

{"title":"Formulation and evaluation of controlled porosity oral osmotic pump tablets of furosemide","authors":"Teena Chackochen Thekkal, Reba Renju, Manju Maria Mathews, B. R","doi":"10.37022/jiaps.v8i3-s.535","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.535","url":null,"abstract":"Oedema is an abnormal accumulation of fluid in the interstitium located beneath the skin and in the cavities of the body which can cause severe pain. Furosemide has been shown to be effective and safe in patients with hypertension and/ or coronary heart disease. Osmotic pump tablets deliver the drug in an optimized manner to maintain drug concentration within the therapeutic window and minimize toxic effects. The major objective of the study was to prepare and evaluate oral controlled porosity osmotic pump tablets of furosemide, to reduce the dosing frequency and thereby side effects, and to release the drug for a prolonged period in a controlled manner that is independent of pH and hydrodynamic activity. Pre-formulation studies and pre-compression parameters of tablet blends of osmotic pump tablets of furosemide were carried out. Oral-controlled porosity osmotic pump tablets of furosemide were prepared and subjected to different evaluation tests. Precompression parameters indicated that granules have a good flow property. All the formulations showed good mechanical strength. All the nine formulations showed a drug release of more than 60% in the 12th hour. Optimised formulation showed a drug release of 99.21% in 12th hr. Stability studies conducted indicate that the product is stable.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139198896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross sectional study to analyse the ADR reported in a hospital during the past three years","authors":"Sangeetha Sukumaran, Varsha Elizabeth Joby, A. Joseph, Aparna Jestin, Jithin N P, Sumayya B Muhammed, Sunu Sebastian, J. Vilapurathu","doi":"10.37022/jiaps.v8i3-s.530","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.530","url":null,"abstract":"Introduction: Cross sectional study is a type of observational study that analyzes data from apopulation, or a representative subset, at a specific point in time-that is, cross sectional data. The causality appraisal is assessment of the probability that the detected adverse event is produced by a specific medication. The most commonly used causality assessment scales are Naranjo Probability Scale and the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) causality scales. The study is to analyze the adverse drug reaction reported in a hospital for the past three years. Aim: A cross sectional study to analyze the ADR reported in a hospital during the past three years. Methodology: A cross sectional observational study was conducted at Nirmala medical centre, Muvattupuzha. ADR reported in the past three years in this hospital were analyzed. Drug leading to ADR, department .gender, observed reaction, severity, Naranjo probability scale and WHO UMC causality assessment were done. Classification of drugs according to their drug class, classification of ADR according to the system, based on severity, sex, Naranjo score, WHO UMC criteria were done. The datas were analysed and represented into graphs. Result: A total of 342 ADR reports were analyzed in this study. The key findings of this study include: Skin-related ADRs were the most frequently reported, affecting 27.83% of cases. The majority of reported ADRs were of moderate severity (56.7%).Naranjo probability scale and WHO-UMC causality assessment indicated that most cases were in the probable category, with 63% and 76%, respectively. The general medicine department had the highest number of reported ADRs. Males accounted for the majority of reported ADRs (57.18%).Cardiovascular agents and antibiotics were the drug classes most commonly associated with reported ADRs, at 25.6% and 22.28%, respectively. Among cardiovascular agents, diuretics were found to be the primary culprits, causing 38.66% of reported ADRs. Conclusion: This study highlights the importance of monitoring, assessing, and documenting ADRs in healthcare facilities, as it provides valuable insights into the prevalence, severity, and causality of adverse drug reactions. This information can contribute to improving patient safety and the rational use of medications in clinical practice.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139202035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cosmetic use related adverse events and need for cosmetovigilance","authors":"Merrin Joseph, Karishma Shaji, Mahin T M, Nandana P B, Krishna Das","doi":"10.37022/jiaps.v8i3-s.524","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.524","url":null,"abstract":"Cosmetics are applied to human body for cleansing, beautifying, promoting attractiveness or altering appearance. Cosmetics are causing adverse events to users, yet evidence about its magnitude is limited among students due self-diagnosis and self-medication .To know about the cosmetic use related adverse events and to enhance awareness regarding cosmetovigilance among the students of Nirmala College of pharmacy, Muvattupuzha by an educational intervention. To assess the prevalence of cosmetics, use among the students of Nirmala college of pharmacy, Muvattupuzha.To identify the cosmetics related adverse events and knowledge , To improve the awareness regarding cosmetovigilance. By online survey using google form. The questionnaire consisted of three parts, demographic profile, utilization pattern, participant's experience of cosmetics-related adverse reactions for the last two years.an awareness program about cosmetovigilance system.  Access the knowledge of students one month after awareness.502 participants,55.2% with pimple ,55.2% with hair loss,41.4% with allergic reaction, dryness of skin, etc.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"538 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139203451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and characterisation of topical emulgel containing neem oil for its antidandruff properties","authors":"Eby George, Dhanish Joseph, Abitha N Jabbar, Khansa Beegam M A, Nimisha Joseph, Mahima Francis, Anju Boban, Ann Maria Alex","doi":"10.37022/jiaps.v8i3-s.508","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.508","url":null,"abstract":"Emulgel is a novel drug delivery system for controlled release of drug. It is suitable for the dual release of drugs. This study focuses on the development and characterization of topical emulgel containing neem oil for its anti-dandruff properties. Neem oil is emulsified using suitable surfactant in the ratio 4:2:1 and the prepared emulsion is incorporated with Carbopol gel base in ratio1:1. A total of 5 formulations were prepared using the polymer carbopol-934. Topical emulgel of neem oil was formulated and subjected to evaluation studies such as organoleptic properties, pH, Viscosity, Spreadibility, Invitro diffusion studies, Accelerated stability studies using ultracentrifugation, SEM analysis and Invitro antifungal properties. Formulation F5 subjected to in vitro oil diffusion study had shown a total release of 65.27% after 8 hours. Korsmeyer-Peppa’s plot had shown that the mechanism of diffusion was non-fickian. Emulgel of neem oil shown zone of inhibition on invitro antifungal study using Candida albicans as fungi. Formulation F5 show highest zone of inhibition of 12mm as compared to other formulations. It was concluded that, formulation of neem oil as a semi solid dual release control emulgel formulation with a time dependant oil diffusion, also add up all the advantage of a semisolid dosage compared to liquids with optimum Spreadibility, stability, aesthetic appearance, adherence to the affected scalp area and with pH that is similar scalp.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139198408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of implantable drug delivery system of embelin for the treatment of breast cancer","authors":"Rincy. K K, Dhanish Joseph, Binsha Urumees, Ann Mariya Jose, Athira Anilan","doi":"10.37022/jiaps.v8i3-s.509","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.509","url":null,"abstract":"Embelin is a traditional herbal medicine that exhibits anti-cancer effects in human breast cancer cells. However, the therapeutic effect of Embelin as Implantable Drug Delivery System is not yet determined. Embelin is having drawbacks like poor bioavailability and toxicity in systemic circulation, so we opt for Implantable Drug Delivery System. In this study, we optimised, developed and evaluated the Implantable Drug Delivery System of Embelin as pellets. The prime objective of the study is to prolong the drug release as much as possible using a combination of naturally occurring biodegradable polymer such as Guar gum, Chitosan, Xanthan gum, Locust bean gum. In this study, integration of Embelin and Chitosan was achieved via Granulation, with the aid of Guar gum as an excipient, followed by Extrusion /spheronisation. In vitro drug release study revealed the chitosan blended Embelin loaded implant possesses a longer, yet steadier, sustained drug release behaviour than the other three bio polymeric implants. It exhibits prolonged drug release of up to nine days and Korsmeyer’s-peppas plot were exhibited.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"240 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139205989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study of clinical profile of viper bite cases in selected hospitals in central kerala","authors":"Anumol Saju, A. Tom, Aby Paul, Swapna Saju, Donavon B. Johnson, Jesyln Joe Thomas, Kuttikkaden Joy Steffi, Joyal M Joll","doi":"10.37022/jiaps.v8i3-s.525","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.525","url":null,"abstract":"Viper bite is a commonly occurring  occupational health hazard to people involved mainly in agricultural sector in tropical and sub-tropical areas.    The aim of the study was to assess the clinical pattern of poisonous snakebites from four selected hospitals in central Kerala. Study site: Carithas Hospital (Kottayam), Little Flower Hospital and Research Centre (Angamaly), Paalana Institute of Medical Sciences (Palakkad) and Charis Medical Mission (Muvattupuzha). Percentage of cases collected from Carithas hospital, Little Flower hospital, Paalana hospital and Charis hospital were 51. The various clinical profile was assessed such as Hb level , symptoms, total leukocyte count, platelet count prothrombin time etc. Conclusion: Practice of locally developed treatment protocol for optimised treatment of viper bite is required.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139201303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of floating controlled drug delivery of anti-ulcer drug loaded microballoons","authors":"Bindumol K C, Flowerlet Mathew, S. Sunil, Angel Jose","doi":"10.37022/jiaps.v8i3-s.532","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.532","url":null,"abstract":"An attempt has been made to develop floating drug delivery system for improving the drug bioavailability by prolongation of gastric residence time of Famotidine in the stomach. The floating microballoons were prepared using polymer Eudragit RS100, HPMC K100M and Ethyl Cellulose. Famotidine was used as the model drug. Nine formulations (F1 to F9) were prepared by varying the ratio of polymers. The prepared Famotidine loaded micro balloons were characterized for percentage yield, particle size analysis, surface morphology, micromeritic properties, drug entrapment efficiency, buoyancy studies and in-vitro drug release. The formulated micro balloons were free flowing. The micro balloons with Eudragit RS100 showed higher buoyancy when compared with HPMC K100M and Ethyl Cellulose. On the basis of micromeritic properties, particle size, percentage yield, morphology, buoyancy study, drug entrapment, optimum in-vitro drug release and satisfactory release kinetics, formulation F2 was selected as an optimum formulation","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"46 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139206999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Insilico Docking Study Involving Antagonistic Activity of CoumarinDerivatives on EGFR and CDK2","authors":"Riya Ann Thomas, Eva Sara Sunil, Anna Abel Fernandez, Soorya Anil, Anjana Antony, Ann Maria Davis, Godwin Thomas, S. T S, Greeshma Sreeram, Elizabeth Abraham P","doi":"10.37022/jiaps.v8i3-s.518","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.518","url":null,"abstract":"Epidemiological evidence suggests that about 25% of cancer occurs due to chronic inflammation, thus it is clear that cancer and inflammation are related. Piroxicam is the one of the drug that is used in the treatment of both cancer and inflammation, but it is having some side effects like constipation, blurring of vision ,skin rashes etc. Coumarin is having both anti-inflammatory and anti-cancer activity so the purpose of this study is to screen the best target among EGFR and CDK2. Docking analysis was carried out using AutoDock4.  From the study it was found that EGFR showed better result compare to CDK2. Also methyl substitution at 8th position and chlorine substitution at 5th position of coumarin showed better activity than standard drug piroxicam and phytoconsitutents isofraxidin  andscopoletin.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139197636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective survey to ascertain the symptoms, health issues and subsequent otc mediction usage during menstruation among college students","authors":"Mintu George, Anagha Melbin, Mary Paul Dominic, Reshma Dominic, Aysha Saja P S, J. Vilapurathu","doi":"10.37022/jiaps.v8i3-s.529","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.529","url":null,"abstract":"Up to 14 days before your period begins, you might see bulging, Migraines, temperament swings, or other physical and enthusiastic changes. These Month to month side effects are known as premenstrual disorder, or PMS. Around 85% of ladies experience some level of PMS. A couple have more serious. Manifestations that disturb work or individual connections, known as premenstrual Dysphoric problem (PMDD). The etiology of these disorders remains uncertain, Research suggests that altered regulation of neurohormones and neurotransmitters is involved.  Study Site: college students studying in Nirmala College of pharmacy Muvattupuzha. Design: The study will be done as an online survey using Google form. The Developed questionnaire consists of knowledge of premenstrual syndrome, Quality of Life, Medication. Conclusion: Premenstrual syndrome and premenstrual dysphoric disorder are Complex but highly treatable disorder and can improved by providing patient education on Premenstrual symptoms and counseling women on lifestyle interventions.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139199237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of patient knowledge, practice and adverse events of insulin administration and storage techniques in patients with diabetes","authors":"A. Tom, Namitha Antony, Pavithra Ashok, M. Ps, Juhy Jojo","doi":"10.37022/jiaps.v8i3-s.520","DOIUrl":"https://doi.org/10.37022/jiaps.v8i3-s.520","url":null,"abstract":"Diabetes mellitus is a group of  metabolic disorder characterised by hyperglycaemia. For effective therapy, correct injection procedures, adequate storage, insulin dose adjustment, meal timing, site rotation, and compliance. The aim of this work is to assess the knowledge and practice of insulin administration and storage techniques in diabetes patients. It is a survey based cross sectional study conducted through  both online and offline modes among diabetic patients consuming insulin in  Ernakulam district. 213 cases were included and it consist of diabetic patients on insulin therapy. About 54.4% of patients were males and 45.6% patients were females. Majority 57.3% experienced hypoglycaemia and 17.3% never experienced it. 51.6% patients were educated by nurse, 25.6% by doctors and only 17.6% were educated by pharmacist. The study presented an insight into the practices of insulin administration and awareness to the diabetic patients, study also extended to other health care professionals in the society.","PeriodicalId":151037,"journal":{"name":"Journal of Innovations in Applied Pharmaceutical Science (JIAPS)","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139199631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}