Journal of Bioactive and Compatible Polymers最新文献_第4页

Development and characterization of skin substitutes from electrospun polycaprolactone/silk fibroin 电纺聚己内酰胺/蚕丝纤维素皮肤替代品的开发和特性分析

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-12-07 DOI: 10.1177/08839115231216998

Gulsah Yildiz, Y. E. Arslan, Burak Derkuş, Billur Sezgin, Yusuf Ziya Menceloglu, G. R. Bayar

{"title":"Development and characterization of skin substitutes from electrospun polycaprolactone/silk fibroin","authors":"Gulsah Yildiz, Y. E. Arslan, Burak Derkuş, Billur Sezgin, Yusuf Ziya Menceloglu, G. R. Bayar","doi":"10.1177/08839115231216998","DOIUrl":"https://doi.org/10.1177/08839115231216998","url":null,"abstract":"Tissue-engineered skin substitutes have great potential to treat chronic wounds and high-degree burns. Existing solutions, such as Integra Dermal Template, are extensively used for skin defects. However, these templates are still lacking in terms of recreating the functionality of the native tissue and providing scarless healing. In this study, polycaprolactone/silk fibroin (PCL/SF)-based nanofibers with varying blends were fabricated and characterized to develop a novel skin substitute. Morphological analysis showed that the nanofiber distribution of each sample was homogenous without showing any beads. In terms of mechanical properties, all the samples other than SF showed sufficient mechanical strength. It was observed that adding a specific amount of SF into the PCL nanofiber improves the tensile strength of the samples due to the introduction of intermolecular interactions from the functional groups of SF. In addition, incorporating SF into PCL improved Young’s modulus of the PCL nanofibers since SF provides stiffness and structural integrity to the overall structure. Water contact angle analysis was performed as the hydrophilicity of a biomaterial is a significant factor in cell functionality. Each sample had a contact angle between 33° and 48°, indicating the adequate hydrophilicity of nanofibers for advanced cell proliferation other than PCL. Cell proliferation and viability studies were conducted with the seeding of primary human keratinocytes on the samples. It was examined that scaffolds containing blends of PCL and SF resulted in higher cell proliferation and viability after 7 days compared to pure PCL and SF nanofibers.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"28 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138594471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymer-induced liquid precursors: How are they being used and what is the effect on dentin remineralization? A scoping review 聚合物诱导液体前体：它们是如何使用的，对牙本质再矿化有何影响？范围审查

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-12-06 DOI: 10.1177/08839115231216997

M. A. A. Fraga, C. S. Garfias, Patricia Akemi Nishitani Shibasaki, A. Correr, M. D. De Goes, R. Puppin-Rontani

{"title":"Polymer-induced liquid precursors: How are they being used and what is the effect on dentin remineralization? A scoping review","authors":"M. A. A. Fraga, C. S. Garfias, Patricia Akemi Nishitani Shibasaki, A. Correr, M. D. De Goes, R. Puppin-Rontani","doi":"10.1177/08839115231216997","DOIUrl":"https://doi.org/10.1177/08839115231216997","url":null,"abstract":"To identify the effectiveness of polymer-induced liquid precursors (PILP) on dentin remineralization and the assessment approaches used to evaluate remineralization. The analyses were done into six stages: (1) Identifying the research question; (2) Identifying the studies; (3) Selecting relevant studies; (4) Plotting the data; (5) Reporting results; and (6) Risk of bias. The searches were carried out in the following databases: PubMed, Web of Science, and Scopus. A total of 247 articles were identified in the electronic database search. After applying the eligibility criteria, only 12 articles were included for data extraction. The outcomes of dentin remineralization patterns were plotted in association to PILP agent type and application mode. The intrafibrillar mineralization occurred in 78% of studies where polyaspartic acid (pAsp) was used, and 50% when the polyacrylic acid (PAA) was used. All the studies where PILP was used in a restorative material (resin composite, glass ionomer, and adhesive system)—extra and intrafibrillar mineralization pattern was found. The association of PILP agents with other materials with potential for mineralization showed beneficial results in remineralization, since they provide a medium to high concentration of calcium and phosphate. The pAsp showed better results for interfibrillar remineralization when compared to PAA. The association with Ca/P release materials or solution Ca P are essentials for mineralization via PILP agent. Further studies are needed to assess the effectiveness of remineralization through PILP agents because the level of evidence of the studies was low.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"49 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138597522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication, characterization, and in vivo implantation of eugenol-loaded nanogels and PCL/Cs electrospun nanofibers for wound healing applications 丁香酚负载纳米凝胶和PCL/Cs静电纺纳米纤维在伤口愈合中的制备、表征和体内植入

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-11-01 DOI: 10.1177/08839115231207337

Fariba Noori, Mahmoud Osanloo, Hamid Reza Moradi, Hamidreza Ghaderi Jafarbeigloo, Mozhgan Jirehnezhadyan, Seyed Amin Kouhpayeh, Mahtab Tirgare, Azam Bozorgi, Arash Goodarzi

{"title":"Fabrication, characterization, and in vivo implantation of eugenol-loaded nanogels and PCL/Cs electrospun nanofibers for wound healing applications","authors":"Fariba Noori, Mahmoud Osanloo, Hamid Reza Moradi, Hamidreza Ghaderi Jafarbeigloo, Mozhgan Jirehnezhadyan, Seyed Amin Kouhpayeh, Mahtab Tirgare, Azam Bozorgi, Arash Goodarzi","doi":"10.1177/08839115231207337","DOIUrl":"https://doi.org/10.1177/08839115231207337","url":null,"abstract":"Developing wound dressings with a high potential to cover damaged skin tissue and facilitate cell adhesion and migration at the injury site is crucial in skin tissue engineering to accelerate wound healing. Electrospun nanofibers from natural/synthetic polymers are amongst the favorable wound dressings with appropriate physicochemical and biological properties. As well, nanoformulations of phenolic phytochemical “eugenol” have been shown to fasten wound healing via various anti-inflammatory and anti-oxidant effects. Herein, we developed a bi-component wound dressing of PCL/Cs electrospun nanofibers and eugenol nanogel to investigate its effects on tissue healing in vivo. PCL/Cs nanofibers were fabricated using an electrospinning method at the 15:1 ratio, and eugenol-loaded nanogels were synthesized by adding carboxymethylcellulose as the gelling agent, and their physicochemical characteristics were assessed. Scaffolds were implanted in a full-thickness excision wound model in Wistar rats, followed up for 21 days. The results showed that electrospun nanofibers had an average diameter of 228 nm with uniform and smooth morphology aligned randomly. Eugenol-loaded nanogel showed an average size distribution of 126 nm. Eugenol-loaded nanogel and nanogel + nanofiber groups significantly reduced wound surface area over 21 days. Histological evaluations showed that Eugenol-loaded nanogel and nanogel + nanofiber groups developed the full-thickness epidermis with the complete epithelium and stratum corneum, angiogenesis, and low macrophage infiltration in which predominantly mature collagen fibers were poorly and well organized, respectively. The combination of eugenol-loaded nanogel + PCL/Cs nanofiber accelerated wound healing by reducing inflammation, and edema along with enhancing angiogenesis, collagen synthesis, and re-epithelialization.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"63 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135566899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of chitosan/polyvinylpyrrolidone hydrogels for controlled amoxicillin release 壳聚糖/聚乙烯吡咯烷酮控制释放阿莫西林凝胶的合成与表征

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-11-01 DOI: 10.1177/08839115231207817

Zerihun Feyisa, Neeraj K Gupta, Gemechu Deressa Edossa, Anandhakumar Sundaramurthy, Ashish Kapoor

{"title":"Synthesis and characterization of chitosan/polyvinylpyrrolidone hydrogels for controlled amoxicillin release","authors":"Zerihun Feyisa, Neeraj K Gupta, Gemechu Deressa Edossa, Anandhakumar Sundaramurthy, Ashish Kapoor","doi":"10.1177/08839115231207817","DOIUrl":"https://doi.org/10.1177/08839115231207817","url":null,"abstract":"Hybrid crosslinked hydrogel-based drug delivery systems can deliver therapeutically beneficial drug release effects through controlled release on a temporal and spatial scale. Due to their tuneable physicochemical properties and the ability to prevent drug degradation, these systems facilitate different physicochemical interactions that control drug release. This research aims to synthesize a potent pH-sensitive crosslinked chitosan/polyvinylpyrrolidone hydrogel using different ratios of both the polymers and varying the glutaraldehyde crosslinking agent amount by the solution casting technique for controlled amoxicillin-release properties to mitigate gastrointestinal tract bacterial infection. The effect of polymer ratios and glutaraldehyde amount is investigated by the developing porosity, gel fraction, and extent of swelling in simulated physiological fluids of pH 1.2, 6.8, and 7.4 and in vitro biodegradation at pH 7.4. Interaction between the polymers with the formation of crosslinked structures, good stability, amorphous phase nature, and honeycomb-like structures of the hydrogels is revealed by Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. Based on these properties, a chitosan/polyvinylpyrrolidone hydrogel (ratio of 60:40) crosslinked with 600 μL glutaraldehyde in 8 g of the polymers displaying adequate swelling in acidic to basic pH and in vitro biodegradation at pH 7.4 is chosen for the in situ loading of 200 mg of the drug amoxicillin. The cumulative drug release in simulated physiological fluids and the drug release kinetics using different models show that the best-fit Korsmeyer-Peppas model suggests amoxicillin release from the matrix follows diffusion and swelling-controlled time-dependent non-Fickian transport related to hydrogel erosion. This composition displays excellent antimicrobial activity against Streptococcus pyogenes and Escherichia coli.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"242 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135371139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A silk fibroin scaffold that accelerates both biodegradation and cell proliferation by incorporating sericin 一种丝素蛋白支架，通过结合丝胶蛋白加速生物降解和细胞增殖

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-11-01 DOI: 10.1177/08839115231207815

Wenjing Zhang, Xiaoxiao Sun, Peng Pan, Xueping Liu, Cheng Hu, Mengmeng Wang, Mingzhong Li, Yu Liu

{"title":"A silk fibroin scaffold that accelerates both biodegradation and cell proliferation by incorporating sericin","authors":"Wenjing Zhang, Xiaoxiao Sun, Peng Pan, Xueping Liu, Cheng Hu, Mengmeng Wang, Mingzhong Li, Yu Liu","doi":"10.1177/08839115231207815","DOIUrl":"https://doi.org/10.1177/08839115231207815","url":null,"abstract":"When 3D silk fibroin scaffolds are used for the regeneration of soft tissues with fast regeneration rates, such as skin dermis, one concern is to accelerate the biodegradation of scaffolds and to match the degradation rate of scaffolds with the regeneration rate of tissues. In this study, sericin was incorporated into 3D silk fibroin scaffolds through crosslinking and followed by freeze-drying. The effects of incorporating sericin on the pore wall microstructure within the scaffolds, the biodegradability of scaffolds and cell proliferation within scaffolds were investigated. It was found that a large number of secondary pores and nanoscale particles were generated on the pore walls within the scaffolds due to the incorporation of sericin and that the number of secondary pores and the size of the particles increased with increasing sericin proportion. The results of in vitro biodegradation and coculture with human umbilical vein vascular endothelial cells demonstrated that the incorporation of sericin not only significantly accelerated the degradation of 3D silk fibroin scaffolds, but also promoted cell adhesion and proliferation. The secondary pores and particles generated on the pore walls inside the fibroin/sericin hybrid scaffolds had a positive contribution to promoting cell adhesion and proliferation. This study provides a biocompatible method for the modification of silk fibroin scaffolds, which can not only accelerate the biodegradation of the scaffold but also promote the adhesion and proliferation of seeded cells.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"240 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135371154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Vancomycin coupled chitosan/PEO nanofibrous scaffold with the desired antibacterial activity as a potential for biomedical application” 万古霉素偶联壳聚糖/PEO纳米纤维支架在生物医学应用中的潜在抗菌活性

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-30 DOI: 10.1177/08839115231207193

引用次数: 0

Design and evaluation of moringa gum-based hydrogel dressings for cutaneous wound healing 辣木胶基水凝胶敷料用于皮肤伤口愈合的设计与评价

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-25 DOI: 10.1177/08839115231199700

Yasir Iqbal, Shahzad Ali Shahid Chatha, Zunera Chauhdary, Abdullah Ijaz Hussain, Ikram Ullah Khan

{"title":"Design and evaluation of moringa gum-based hydrogel dressings for cutaneous wound healing","authors":"Yasir Iqbal, Shahzad Ali Shahid Chatha, Zunera Chauhdary, Abdullah Ijaz Hussain, Ikram Ullah Khan","doi":"10.1177/08839115231199700","DOIUrl":"https://doi.org/10.1177/08839115231199700","url":null,"abstract":"The study aimed to evaluate moringa gum (MG) and carboxymethyl moringa (CMG) for their possible use in hydrogel-based dressings to treat cutaneous wounds. Initially, MG was characterized for its physical, functional, morphological, and thermal properties. The MG and CMG have shown limited toxicity as indicated by hemolytic assay where values were less than 2.5%. Furthermore, these samples also showed antimicrobial potential. The antioxidant potential of MG was slightly greater than its carboxymethyl derivative. Afterward, MG and CMG were encapsulated in sodium alginate-based hydrogel films. These films showed good physical attributes necessary for the end application. These films were tested in an open wound model in rats. The MG containing films showed the highest % wound contraction on the 10th day, that is,79.42 ± 0.46 with low levels of IL6 and TNF alfa. Out of MG and CMG films, the native moringa gum-based thin film showed comparatively higher potential for wound healing and in the future could be a potential candidate for wound healing dressings.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135815691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Levan-based bioactive hydrogels containing herbal liposome in treating acute wounds 含草药脂质体的以levan为基础的生物活性水凝胶治疗急性伤口

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-20 DOI: 10.1177/08839115231198528

Özlem Erdal Altıntaş, Pınar Aytar Çelik

{"title":"Levan-based bioactive hydrogels containing herbal liposome in treating acute wounds","authors":"Özlem Erdal Altıntaş, Pınar Aytar Çelik","doi":"10.1177/08839115231198528","DOIUrl":"https://doi.org/10.1177/08839115231198528","url":null,"abstract":"Hydrogels in active wound care products are 3D polymeric scaffolds that provide the desired moisture balance in the wound area with their high water retention capacity. Thanks to their biocompatible properties, flexible and porous structures, and high hydrophilic properties, they have frequently been preferred in the repair and regeneration of cells and tissues and the controlled release of bioactive substances to the target area. In this study, hydrogel structures were developed for the first time with levan produced by Halomonas elongata 153B halophilic bacteria. Extracts from Plantago lanceolata L., commonly known as a wound herb, which has medicinal importance for cell regeneration, ensuring tissue integrity in a short time and reducing infections in the wound area, were obtained and extract-loaded liposome structures were formed for controlled release into the wound area. The wound healing efficacy of the composite material developed by loading herbal liposomes into levan-based hydrogel structures was evaluated in an in vitro wound model. Thus, a natural, biocompatible, biodegradable, and functional wound care product containing herbal liposomes suitable for both clinical applications and point-of-care use has been developed. The developed bioactive hydrogels are a promising therapeutic approach for the healing of acute wounds. Graphical abstract [Formula: see text]","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136308953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the therapeutic effect of chitosan scaffolds loaded with the different concentrations of Hesperidin in bone regeneration in rat model 不同浓度橙皮苷负载壳聚糖支架对大鼠骨再生模型的疗效评价

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-01 DOI: 10.1177/08839115231198529

Mohadese Gharibblouk, Maryam Haji Ghasem Kashani, Meysam Nasiri, Arian Ehterami, Tayebeh Sadat Tabatabai, Majid Salehi

{"title":"Evaluation of the therapeutic effect of chitosan scaffolds loaded with the different concentrations of Hesperidin in bone regeneration in rat model","authors":"Mohadese Gharibblouk, Maryam Haji Ghasem Kashani, Meysam Nasiri, Arian Ehterami, Tayebeh Sadat Tabatabai, Majid Salehi","doi":"10.1177/08839115231198529","DOIUrl":"https://doi.org/10.1177/08839115231198529","url":null,"abstract":"Bone grafts are widely used to improve bone healing but this method is costly and make some serious problems like infection in long-term use. To solve these problems, tissue engineering by using scaffolds made of different materials can be used as a supportive structure to enhance bone healing. In the current study, 3-D chitosan (CS) bone scaffold was developed by freeze-drying techniques for bone tissue engineering. The efficiency of the CS scaffold was improved by loading different concentrations of Hesperidin (Hes). Scaffolds were characterized by different mechanical and biological tests to evaluate their properties. In addition, the effect of scaffolds on bone healing was evaluated by a rat femur defect model. Results showed that the porosity of scaffolds was about 45–257 µm and Hes has a negative effect on the mechanical strength of scaffolds. Also, due to the hydrophilic properties of Hes, the degradation rate increased. Histological and CT-Scan evaluation showed that the treated groups which scaffold loaded with 1% and 10% of Hes were fully replaced by new bone and collagenous matrix compared to control and Hesperidin (0%, 0.01%, 0.1%) treated groups. The Runx2 gene expression was significantly increased by 1% and 10% compared to other groups. These results showed the positive effect of the fabricated scaffold on osteogenesis and bone healing and the possibility of using it in clinical trials.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135347169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan and dextran hydrogel as a filler for possible application in orthopedic implantation surgery 壳聚糖和葡聚糖水凝胶作为填充材料在骨科植入术中的应用前景

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-01 DOI: 10.1177/08839115231195791

Abigail F Wu, Audrey L. Wu, T. Yeh, Pei-Chun Wong, Jia-Lin Wu

引用次数: 0