Design and evaluation of moringa gum-based hydrogel dressings for cutaneous wound healing

IF 2.1 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-25 DOI:10.1177/08839115231199700

Yasir Iqbal, Shahzad Ali Shahid Chatha, Zunera Chauhdary, Abdullah Ijaz Hussain, Ikram Ullah Khan

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引用次数: 0

Abstract

The study aimed to evaluate moringa gum (MG) and carboxymethyl moringa (CMG) for their possible use in hydrogel-based dressings to treat cutaneous wounds. Initially, MG was characterized for its physical, functional, morphological, and thermal properties. The MG and CMG have shown limited toxicity as indicated by hemolytic assay where values were less than 2.5%. Furthermore, these samples also showed antimicrobial potential. The antioxidant potential of MG was slightly greater than its carboxymethyl derivative. Afterward, MG and CMG were encapsulated in sodium alginate-based hydrogel films. These films showed good physical attributes necessary for the end application. These films were tested in an open wound model in rats. The MG containing films showed the highest % wound contraction on the 10th day, that is,79.42 ± 0.46 with low levels of IL6 and TNF alfa. Out of MG and CMG films, the native moringa gum-based thin film showed comparatively higher potential for wound healing and in the future could be a potential candidate for wound healing dressings.

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辣木胶基水凝胶敷料用于皮肤伤口愈合的设计与评价

本研究旨在评价辣木胶(MG)和羧甲基辣木(CMG)在水凝胶基敷料中治疗皮肤伤口的可能性。最初，MG被表征为其物理、功能、形态和热性能。溶血试验显示，MG和CMG毒性有限，其值小于2.5%。此外，这些样品还显示出抗菌潜力。MG的抗氧化能力略大于其羧甲基衍生物。然后，将MG和CMG包封在海藻酸钠基水凝胶膜中。这些薄膜表现出最终应用所需的良好物理属性。这些薄膜在大鼠开放性伤口模型中进行了测试。含MG膜创面收缩率在第10天最高，为79.42±0.46,il - 6和TNF - α水平较低。在MG和CMG薄膜中，天然辣木胶基薄膜显示出较高的伤口愈合潜力，未来可能成为伤口愈合敷料的潜在候选材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bioactive and Compatible Polymers 工程技术-材料科学：生物材料

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： The use and importance of biomedical polymers, especially in pharmacology, is growing rapidly. The Journal of Bioactive and Compatible Polymers is a fully peer-reviewed scholarly journal that provides biomedical polymer scientists and researchers with new information on important advances in this field. Examples of specific areas of interest to the journal include: polymeric drugs and drug design; polymeric functionalization and structures related to biological activity or compatibility; natural polymer modification to achieve specific biological activity or compatibility; enzyme modelling by polymers; membranes for biological use; liposome stabilization and cell modeling. This journal is a member of the Committee on Publication Ethics (COPE).