Journal of Bioactive and Compatible Polymers最新文献

Gellan gum as a promising transplantation carrier for differentiated progenitor cells in ophthalmic therapies 结冷胶是眼科疗法中一种前景看好的分化祖细胞移植载体

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-09-17 DOI: 10.1177/08839115241278739

Mthabisi Talent George Moyo, Terin Adali

{"title":"Gellan gum as a promising transplantation carrier for differentiated progenitor cells in ophthalmic therapies","authors":"Mthabisi Talent George Moyo, Terin Adali","doi":"10.1177/08839115241278739","DOIUrl":"https://doi.org/10.1177/08839115241278739","url":null,"abstract":"Stem cell-based therapies for various ocular conditions are increasingly gaining traction in ophthalmic treatments, with hydrogel-based polymers playing a pivotal role. Current stem cell delivery methods face challenges such as limited cell retention, immunological rejection, and uneven dispersion. Hence, there is a critical demand for innovative delivery systems to enhance the viability, localization, and integration of transplanted stem cells while minimizing adverse effects. Central to this advancement is the meticulous selection of appropriate materials. Among the promising options, gellan gum, a versatile polysaccharide, is emerging as a potential carrier for differentiated progenitor cells in regenerative medicine, particularly in ophthalmology. This study explores the utilization of gellan gum hydrogels as carriers, focusing on their biocompatibility, customizable gelation properties, and ability to encapsulate, transplant, and biofunctionalize cells. Through a review of literature, the impact of gellan gum hydrogels on cell viability parameters is investigated, revealing their potential for promoting tissue regeneration and functional recovery in ocular diseases. Furthermore, this study compares gellan gum systems utilizing natural and synthetic polymers, discerning differences in efficacy, biocompatibility, and suitability for diverse applications in regenerative ophthalmology. This review highlights the promising role of gellan gum in ophthalmic therapies, providing valuable insights into future directions and hurdles in this evolving field.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Textile waste-based biosensors for medical monitoring 基于纺织废物的医疗监测生物传感器

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-09-17 DOI: 10.1177/08839115241279867

Monica Sikka

引用次数: 0

Sport technology in combination with neural guidance channels loaded with Inula helenium extract for peripheral nervous system repair 运动技术与神经引导通道相结合，含有茵陈提取物，可修复周围神经系统

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-09-10 DOI: 10.1177/08839115241257204

Weiyuan Ying

引用次数: 0

Dual drug release profiles of salicylate-based polymers and encapsulated chlorhexidine as potential periodontitis treatments 作为潜在牙周炎治疗药物的水杨酸盐基聚合物和包封洗必泰的双重药物释放特征

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-09-10 DOI: 10.1177/08839115241279855

Kenya Whitaker-Brothers, M Ragib Hasan, Umme Tamima, Kathryn E Uhrich

{"title":"Dual drug release profiles of salicylate-based polymers and encapsulated chlorhexidine as potential periodontitis treatments","authors":"Kenya Whitaker-Brothers, M Ragib Hasan, Umme Tamima, Kathryn E Uhrich","doi":"10.1177/08839115241279855","DOIUrl":"https://doi.org/10.1177/08839115241279855","url":null,"abstract":"Salicylate-based poly(anhydride-esters; SAPAEs) have demonstrated wound healing properties due to salicylic acid (SA) release during polymer degradation. Additionally, the polymers are deformable and self-adhesive due to their low Young’s modulus, lower glass transition temperature ( Tg), and inherent tackiness at body temperature. These properties make them particularly well-suited for therapeutic use in the bacteria-laden environment of the oral cavity. To enhance their therapeutic capabilities, the antiseptic chlorhexidine dihydrochloride was physically incorporated into SAPAEs for dual release of antiseptic and anti-inflammatory upon degradation. This study analyzes the thermomechanical properties of two SAPAE compositions (adipate homopolymer and 50:50 adipate:sebacate copolymer) and the release of chlorhexidine (incorporated at 10% (w/w)) from these polymers. Polymer adhesivity was monitored as a function of chlorhexidine incorporation and in vitro degradation time. Throughout in vitro degradation, the polymer systems had a low Young’s modulus and a Tg at or near body temperature. Incorporation of the antiseptic further decreased Young’s modulus and increased both the Tg and adhesivity. The release profiles were also evaluated and determined to be similar for the homopolymer and copolymer, although the homopolymer degradation occurred over a longer time period. Overall, the SAPAE systems have favorable properties for periodontal disease treatments by virtue of their controlled degradability, deformability, adhesivity, and release profiles with encapsulated antiseptic.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of pH-sensitive polymeric micelle drug carries for potential cancer chemotherapy applications 合成 pH 值敏感的聚合物胶束药物载体，用于潜在的癌症化疗应用

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-09-02 DOI: 10.1177/08839115241273908

Uyen Thu Pham, Nguyen Thi Dung, Nhung Thi Dinh, My Hanh Do Thi, Mai Anh Nguyen, Toan Quoc Tran, Hung Tien Le, Dung Thuy Nguyen Pham, Duong Thanh Nguyen

{"title":"Synthesis of pH-sensitive polymeric micelle drug carries for potential cancer chemotherapy applications","authors":"Uyen Thu Pham, Nguyen Thi Dung, Nhung Thi Dinh, My Hanh Do Thi, Mai Anh Nguyen, Toan Quoc Tran, Hung Tien Le, Dung Thuy Nguyen Pham, Duong Thanh Nguyen","doi":"10.1177/08839115241273908","DOIUrl":"https://doi.org/10.1177/08839115241273908","url":null,"abstract":"Alpha mangostin, a natural xanthone derivative from mangosteen fruit pericarp, exhibits antiproliferative and apoptotic effects on different cancer cells by inhibiting cell cycle progression, inducing apoptosis, and modulating signaling pathways. However, this candidate is limited in medical treatment due to the poor water solubility. Nanoparticles have emerged as promising drug delivery systems to improve drug delivery efficiency but one of the problem of nanoparticles is the capability of endosomal escape. Therefore, pH-sensitive polymer nanosystems were utilized for targeted drug delivery, and enhanced efficacy by offering controlled release and endosomal escape capabilities. This study aimed to synthesize PEG- P(Asp-Hyd-Man) copolymer and create micelle for alpha mangostin delivery. The micelles were measured with particle size average of 80.2 ± 15 nm, and the PDI of 0.17. Additionally, the release behavior of alpha mangostin was examined in vitro that show pH-sensitive polymeric micelles rapidly release at pH 5.0 compared with the arterial pH 7.4. The findings of this study are significant in the development of an effective drug delivery system using alpha mangostin and other therapeutic agents.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin E-poly(2-oxazolin)-ciprofloxacin conjugates that enter bacterial cells via their efflux pumps 通过外排泵进入细菌细胞的维生素 E-聚（2-恶唑啉）-环丙沙星共轭物

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-08-26 DOI: 10.1177/08839115241267807

Alina Romanovska, Jonas Tophoven, Volker Brandt, Marina Breisch, Joerg C. Tiller

{"title":"Vitamin E-poly(2-oxazolin)-ciprofloxacin conjugates that enter bacterial cells via their efflux pumps","authors":"Alina Romanovska, Jonas Tophoven, Volker Brandt, Marina Breisch, Joerg C. Tiller","doi":"10.1177/08839115241267807","DOIUrl":"https://doi.org/10.1177/08839115241267807","url":null,"abstract":"Rendering established antibiotics by derivatization or formulation is a promising way to quickly obtain higher active antibiotics and to address antibiotic resistant bacterial strains. The antibiotic ciprofloxacin (CIP) conjugated with amphiphilic blockcopoly(2-oxazoline)s (POx) shows greatly enhanced antimicrobial activity, reduces resistance formation, and is active against CIP-resistant bacterial cells with overexpressed efflux pumps. In order to design CIP conjugates with comparable performance, but higher biocompatibility, the hydrophobic POx-block was substituted by a modified α-Tocopherol (VitE), which is predominantly referred to as vitamin E. Modification of VitE with 4-bromomethylbenzoyl bromide leads to a highly active initiator for POx synthesis. Using this initiator for the living cationic polymerization of 2-methyl-2-oxazoline leads to fully end-group functionalized PMOx. Conjugation of these polymers with CIP results in non-cytotoxic conjugates with improved CIP activity. These VitE-PMOx-EDA-xCIP conjugates enter E. coli cells via their efflux pumps. In case of E. coli with overexpressed efflux pumps (typical for resistant bacteria), the molar activity of the novel CIP conjugates is up to 100 times higher than free CIP, indicating potential of polymer conjugation with antibiotics to overcome bacterial resistances.[Formula: see text]","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium phosphate graphene with tailorable phosphate and oxygen content for increased osteogenic activity 磷酸钙石墨烯具有可定制的磷酸和氧含量，可提高成骨活性

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-08-19 DOI: 10.1177/08839115241267796

Jason D Orlando, Chenyun Deng, Anne M Arnold, Jing-yi Zhou, Walker Vickery, Stefanie Sydlik

{"title":"Calcium phosphate graphene with tailorable phosphate and oxygen content for increased osteogenic activity","authors":"Jason D Orlando, Chenyun Deng, Anne M Arnold, Jing-yi Zhou, Walker Vickery, Stefanie Sydlik","doi":"10.1177/08839115241267796","DOIUrl":"https://doi.org/10.1177/08839115241267796","url":null,"abstract":"The treatment of critical bone injuries using autografts and metallic hardware, though effective, carries drawbacks yet to be addressed by modern interventions. One way that researchers have sought to avoid these complications is using bioresorbable synthetic grafts. Ideally, these materials possess mechanical properties like that of bone and support the site of injury until absorbed and replaced by native bone. In this work we seek to continue the work of optimizing the synthesis of one synthetic graft candidate, calcium phosphate graphene (CaPG). CaPG is a functional graphenic material (FGM) made using the Arbuzov reaction to covalently seed polyphosphates on the graphenic backbone. This material releases calcium and phosphate ions and has been shown to induce osteogenesis. Herein, we investigate reaction conditions and demonstrate the ability to tailor the functionalization of CaPG. The differences in these properties were found to affect mechanical properties, ion elution, as well as calcium deposition of stem cells when measured via Alizarin Red S (ARS). These results continue to demonstrate the potential of CaPG scaffolds as tunable materials to promote bone regeneration.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and antibacterial ability of photodynamic antibacterial nanoparticles with ammonium cationic groups 带有阳离子铵基团的光动力抗菌纳米粒子的制备和抗菌能力

IF 2.1 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-08-09 DOI: 10.1177/08839115241268926

Zunyu Jiang, Rong Yang, Yang Sheng, Yixin Sun, Jian Li, Mark Bradley, Rong Zhang

{"title":"Preparation and antibacterial ability of photodynamic antibacterial nanoparticles with ammonium cationic groups","authors":"Zunyu Jiang, Rong Yang, Yang Sheng, Yixin Sun, Jian Li, Mark Bradley, Rong Zhang","doi":"10.1177/08839115241268926","DOIUrl":"https://doi.org/10.1177/08839115241268926","url":null,"abstract":"With the increasing infection of drug-resistant bacteria, it has become a great challenge for researchers to find new approaches to eradicate drug-resistant bacteria and their biofilms. Photodynamic antimicrobial chemotherapy (PACT) is an indispensable part of the new anti-bacterial strategy because of its unique anti-bacterial mechanism, which can effectively inactivate drug-resistant bacteria without inducing further drug resistance. In this work, nanoparticles with N-isopropylacrylamide and methacryloxyethyltrimethyl ammonium chloride as monomers, and loaded with a fluorescent conjugated polymer were successfully prepared by microemulsion polymerization. The average particle size ranged from 100 to 200 nm. The nanoparticles could disperse in water steadily according to their zeta potential analysis. The nanoparticles generated singlet oxygen upon exposing to light with wavelength of 500–700 nm. Their PACT efficiency was investigated against Escherichia coli, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus respectively. The results indicated that the antibacterial ability of nanparticles were excellent as the concentration was more than 0.01 mg/mL and the illumination time was 30 min. When the mass concentration of the nanoparticles was equal to or more than 0.05 mg/mL, the antibacterial mechanism was dominated by cation action, and when the concentration was equal or lower than 0.01 mg/mL, the antibacterial ability of the nanoparticles was improved effectively by photodynamic action. The antibacterial rate of the nanoparticle solutions against the bacteria in the biofilm was quantitatively studied, and it was proved that the nanoparticles eliminated bacteria in the biofilm effectively with a nanoparticle concentration of 0.2 mg/mL or more. The results indicated that the nanoparticles could effectively penetrate the biofilm to kill bacteria inside the biofilm by light illumination.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a chitosan/propolis-based polymeric system: Characterization, biocompatibility, and modulation of transcription factor expression 开发壳聚糖/卫矛聚合系统：特性、生物相容性和转录因子表达调控

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-08-03 DOI: 10.1177/08839115241267819

Raquel Velázquez-Rodríguez, Amaury Pozos-Guillén, Martha Gabriela Chuc-Gamboa, Juan Valerio Cauich-Rodríguez, Héctor Flores-Reyes, Francisco Javier Tejeda-Nava, Fernando Javier Aguilar-Perez, Diana Maria Escobar Garcia

{"title":"Development of a chitosan/propolis-based polymeric system: Characterization, biocompatibility, and modulation of transcription factor expression","authors":"Raquel Velázquez-Rodríguez, Amaury Pozos-Guillén, Martha Gabriela Chuc-Gamboa, Juan Valerio Cauich-Rodríguez, Héctor Flores-Reyes, Francisco Javier Tejeda-Nava, Fernando Javier Aguilar-Perez, Diana Maria Escobar Garcia","doi":"10.1177/08839115241267819","DOIUrl":"https://doi.org/10.1177/08839115241267819","url":null,"abstract":"Chitosan (CHT) and propolis (P) are natural materials with antiseptic, anti-inflammatory, antimicrobial, and mucoadhesive properties with many applications in orthopaedia dentistry. The objective of this study was to develop a low molecular weight (LMW) and medium molecular weight (MMW) chitosan polymeric system with propolis at different concentrations (0.31%, 0.62%, 1.25%, 2.5%, and 5%) and to evaluate the effect in terms of their cell interaction with dental pulp fibroblasts. FTIR spectra of both molecular weights CHT’s films with propolis show increased transmittance bands at 1730–1720 cm−1 and 1460 cm−1, indicating the presence of propolis ethanolic extract in the organic matrix. Contact angles test to determine hydrophobicity CHT films functionalized with propolis exhibit a more hydrophobic surface as propolis concentration increases. Cytotoxicity showed synergy between chitosan and propolis; the highest proliferation was observed in LMW CHT with 0.31% of propolis. Membranes made with CHT of both molecular weights plus propolis in an inflammatory stage (cells previously treated with LPS) can inhibit the expression of NF-k-B, MAPK, and VEGF. A polymeric system based on chitosan/ethanolic extract propolis could be a future alternative treatment for oral ulcers.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination eEF2K gene and drug delivery for treatment of breast cancer 结合 eEF2K 基因和药物输送治疗乳腺癌

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-08-03 DOI: 10.1177/08839115241267809

Cansu Umran Tunc, Nitish Khurana, Hamidreza Ghandehari

{"title":"Combination eEF2K gene and drug delivery for treatment of breast cancer","authors":"Cansu Umran Tunc, Nitish Khurana, Hamidreza Ghandehari","doi":"10.1177/08839115241267809","DOIUrl":"https://doi.org/10.1177/08839115241267809","url":null,"abstract":"Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed in a wide variety of cancer types, including hormone receptor positive breast cancer. Targeting of eEF2K has demonstrated anti-tumor activity with the potential of enhanced treatment efficacy in combination with chemotherapy. Here, we describe gold nanoparticle (AuNPs) based delivery of siRNAs enabling eEF2K knockdown in combination with doxorubicin (DOX) to estrogen receptor (ER) positive breast cancer (MCF7) cells. The siRNAs and DOX were co-delivered on the same NP or delivered on separate NPs in a mixture at various siRNA:drug ratios. Effective inhibition of eEF2K expression was provided together with delivery of DOX leading to the enhanced inhibition of cancer cell proliferation compared to DOX delivery alone. siRNA:DOX ratio of 1:2.25 demonstrated synergistic inhibition of cancer cell proliferation. Delivery of eEF2K siRNAs and DOX on separate NPs showed anti-proliferative activity superior to co-delivery on the same NP. These results suggest that eEF2K inhibition enhanced the anticancer activity of chemotherapy on MCF7 breast cancer cells and that the delivery method of the therapeutics had an influence on cytotoxicity.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0