Journal of Bioactive and Compatible Polymers最新文献_第2页

Development of a chitosan/propolis-based polymeric system: Characterization, biocompatibility, and modulation of transcription factor expression 开发壳聚糖/卫矛聚合系统：特性、生物相容性和转录因子表达调控

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-08-03 DOI: 10.1177/08839115241267819

Raquel Velázquez-Rodríguez, Amaury Pozos-Guillén, Martha Gabriela Chuc-Gamboa, Juan Valerio Cauich-Rodríguez, Héctor Flores-Reyes, Francisco Javier Tejeda-Nava, Fernando Javier Aguilar-Perez, Diana Maria Escobar Garcia

{"title":"Development of a chitosan/propolis-based polymeric system: Characterization, biocompatibility, and modulation of transcription factor expression","authors":"Raquel Velázquez-Rodríguez, Amaury Pozos-Guillén, Martha Gabriela Chuc-Gamboa, Juan Valerio Cauich-Rodríguez, Héctor Flores-Reyes, Francisco Javier Tejeda-Nava, Fernando Javier Aguilar-Perez, Diana Maria Escobar Garcia","doi":"10.1177/08839115241267819","DOIUrl":"https://doi.org/10.1177/08839115241267819","url":null,"abstract":"Chitosan (CHT) and propolis (P) are natural materials with antiseptic, anti-inflammatory, antimicrobial, and mucoadhesive properties with many applications in orthopaedia dentistry. The objective of this study was to develop a low molecular weight (LMW) and medium molecular weight (MMW) chitosan polymeric system with propolis at different concentrations (0.31%, 0.62%, 1.25%, 2.5%, and 5%) and to evaluate the effect in terms of their cell interaction with dental pulp fibroblasts. FTIR spectra of both molecular weights CHT’s films with propolis show increased transmittance bands at 1730–1720 cm−1 and 1460 cm−1, indicating the presence of propolis ethanolic extract in the organic matrix. Contact angles test to determine hydrophobicity CHT films functionalized with propolis exhibit a more hydrophobic surface as propolis concentration increases. Cytotoxicity showed synergy between chitosan and propolis; the highest proliferation was observed in LMW CHT with 0.31% of propolis. Membranes made with CHT of both molecular weights plus propolis in an inflammatory stage (cells previously treated with LPS) can inhibit the expression of NF-k-B, MAPK, and VEGF. A polymeric system based on chitosan/ethanolic extract propolis could be a future alternative treatment for oral ulcers.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"88 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination eEF2K gene and drug delivery for treatment of breast cancer 结合 eEF2K 基因和药物输送治疗乳腺癌

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-08-03 DOI: 10.1177/08839115241267809

Cansu Umran Tunc, Nitish Khurana, Hamidreza Ghandehari

{"title":"Combination eEF2K gene and drug delivery for treatment of breast cancer","authors":"Cansu Umran Tunc, Nitish Khurana, Hamidreza Ghandehari","doi":"10.1177/08839115241267809","DOIUrl":"https://doi.org/10.1177/08839115241267809","url":null,"abstract":"Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed in a wide variety of cancer types, including hormone receptor positive breast cancer. Targeting of eEF2K has demonstrated anti-tumor activity with the potential of enhanced treatment efficacy in combination with chemotherapy. Here, we describe gold nanoparticle (AuNPs) based delivery of siRNAs enabling eEF2K knockdown in combination with doxorubicin (DOX) to estrogen receptor (ER) positive breast cancer (MCF7) cells. The siRNAs and DOX were co-delivered on the same NP or delivered on separate NPs in a mixture at various siRNA:drug ratios. Effective inhibition of eEF2K expression was provided together with delivery of DOX leading to the enhanced inhibition of cancer cell proliferation compared to DOX delivery alone. siRNA:DOX ratio of 1:2.25 demonstrated synergistic inhibition of cancer cell proliferation. Delivery of eEF2K siRNAs and DOX on separate NPs showed anti-proliferative activity superior to co-delivery on the same NP. These results suggest that eEF2K inhibition enhanced the anticancer activity of chemotherapy on MCF7 breast cancer cells and that the delivery method of the therapeutics had an influence on cytotoxicity.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"54 5 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced nephrotoxicity of epichlorohydrin-crosslinked β-cyclodextrin nanoparticles (βCDNPs) and its enhanced binding with hydrophobic compounds 环氧氯丙烷交联β-环糊精纳米颗粒（βCDNPs）的肾毒性降低及其与疏水性化合物的结合力增强

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-08-03 DOI: 10.1177/08839115241268608

Anh Thi Ngoc Doan, Natsuki Kojima, Kazuo Sakurai

{"title":"Reduced nephrotoxicity of epichlorohydrin-crosslinked β-cyclodextrin nanoparticles (βCDNPs) and its enhanced binding with hydrophobic compounds","authors":"Anh Thi Ngoc Doan, Natsuki Kojima, Kazuo Sakurai","doi":"10.1177/08839115241268608","DOIUrl":"https://doi.org/10.1177/08839115241268608","url":null,"abstract":"This paper explores the development and characterization of epichlorohydrin-crosslinked β-cyclodextrin nanoparticles (βCDNPs) for drug delivery, focusing on their interaction with hydrophobic drugs and biocompatibility. We synthesized βCDNPs using β-cyclodextrin (βCD) and epichlorohydrin (ECH). Our study assessed the biocompatibility and safety of βCDNPs, particularly in avoiding nephrotoxicity commonly associated with βCD, by examining their interaction with cholesterol and conducting survival analyses in mice at various dosing concentrations. Additionally, we highlight the advantages of using diffusion-ordered NMR spectroscopy (DOSY) to determine the enhanced binding constants of βCDNPs with hydrophobic compounds, in comparison with the solubility method, Job plot analysis, and isothermal titration calorimetry (ITC). We demonstrated the enhanced binding capacity of βCDNPs compared to βCD alone and established the polymerization of βCD as a significant factor in this enhancement. Our findings suggest that βCDNPs show promise as drug delivery systems due to their improved solubility, stability, and safety profiles.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"37 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calendula officinalis extract-loaded conduits improved sciatic nerve injury repair through upregulation of BDNF and GFAP 金盏花提取物负载导管通过上调 BDNF 和 GFAP 改善坐骨神经损伤修复

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-06-22 DOI: 10.1177/08839115241258150

Feng Xu, GuiBin Su

引用次数: 0

Synthesis and characterization of amine functionalized cellulose nanogel for transdermal drug delivery 用于透皮给药的胺功能化纤维素纳米凝胶的合成与表征

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-06-21 DOI: 10.1177/08839115241261421

Antoniyar Arockia Raj, Subramanian Sundaramoorthy

{"title":"Synthesis and characterization of amine functionalized cellulose nanogel for transdermal drug delivery","authors":"Antoniyar Arockia Raj, Subramanian Sundaramoorthy","doi":"10.1177/08839115241261421","DOIUrl":"https://doi.org/10.1177/08839115241261421","url":null,"abstract":"This study presents the synthesis and characterization of an amine-functionalized cellulose nanogel (AFCNG) for potential biomedical applications. AFCNG is synthesized using a combination of acid hydrolysis, TEMPO oxidation, and EDC/NHS-mediated coupling via amide linkage. Biodegradable AFCNG is formulated with a mean size of 74 nm through a regeneration process. The characterization of AFCNG is performed using various techniques such as FTIR spectroscopy, XRD, XPS, Zeta potential, DLS, HRSEM, and TGA. The result reveals that the anionic AFCNG is amorphous, highly stable in colloidal form, and has a higher degradation temperature and water absorption capacity. Biodegradation of AFCNG is also assessed by incubating it with lysozyme for 5 weeks, which results in a degradation level of 83%. There is negligible hemolytic activity and less cytotoxicity toward 3T3 cells induced by the AFCNG. The model drug, curcumin, is effectively loaded on AFCNG, which is highly released at an acidic pH by using the Franz diffusion method. The anionic ligand-based CAFCNG is effectively conjugated with the cationic folic acid receptors on the surface of B16-F10 cell lines through receptor-mediated endocytosis. The resulting CAFCNG shows notable cytotoxicity to B16-F10 cells. The results imply that CAFCNG is a suitable candidate for the treatment of skin cancers by using an effective transdermal drug carrier.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"38 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tribute 致敬

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-06-21 DOI: 10.1177/08839115241260096

Kathryn Uhrich

引用次数: 0

Development of cellulose-based films containing salicylic acid for wound dressing applications: Fabrication, properties and in vitro assessment 开发用于伤口敷料的含水杨酸的纤维素基薄膜：制作、性能和体外评估

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-05-31 DOI: 10.1177/08839115241253560

Mohd Ibnu Haikal Ahmad Sohaimy, Muhammad Amir Amzar Ismail, Azwani Sofia Ahmad Khiar, Norizah Mhd Sarbon, Nora Salina Md Salim, Hanis Nadia Yahya, Mohd Ikmar Nizam Mohamad Isa

{"title":"Development of cellulose-based films containing salicylic acid for wound dressing applications: Fabrication, properties and in vitro assessment","authors":"Mohd Ibnu Haikal Ahmad Sohaimy, Muhammad Amir Amzar Ismail, Azwani Sofia Ahmad Khiar, Norizah Mhd Sarbon, Nora Salina Md Salim, Hanis Nadia Yahya, Mohd Ikmar Nizam Mohamad Isa","doi":"10.1177/08839115241253560","DOIUrl":"https://doi.org/10.1177/08839115241253560","url":null,"abstract":"A wound dressing is important to ensure an efficient healing process while protecting the wound area. This research study combined 2-hydroxyethyl cellulose (2HEC)—an etherified cellulose derivative with salicylic acid (SA) to develop a single layer and investigate the 2HEC viability as wound dressing material. Nine different samples with different compositions of SA, from 5 wt.% to 40 wt.% (with an interval of 5 wt.%) and one control sample without adding SA were prepared via the solution casting method. The 2HEC-SA films were studied regarding the effects of SA composition on antimicrobial properties ( Staphylococcus aureus) via the well-diffusion method. Additionally, degradability, mechanical properties, X-ray diffraction (XRD), and Fourier transform infrared (FTIR) of 2HEC-SA films have also been tested. The strongest antimicrobial effect of 2HEC-SA film was obtained at 40 wt.% with a 16 mm inhibition zone diameter. There was a noticeable decreasing weight loss pattern in the degradation test and the tensile strength of 2HEC-SA film when the composition of salicylic acid is increased. 2HEC-SA film changes phases from amorphous to crystalline starting at 25 wt.% of salicylic acid as seen through XRD, while FTIR shows that complexation of 2HEC and salicylic acid occurred at 1050 cm−1.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"88 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141194328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indigenous Ethiopian traditional medicinal plant leaf extract, Croton macrostachyus, loaded PCL electrospun nanofibrous mat as potential wound dressing: In vitro analysis 埃塞俄比亚本土传统药用植物巴豆叶提取物负载 PCL 电纺纳米纤维垫，可作为潜在的伤口敷料：体外分析

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-05-25 DOI: 10.1177/08839115241256950

Adamu Biruk Fentahun, Gao Jing, Yuan Xiangnan, Tan Shaojie

{"title":"Indigenous Ethiopian traditional medicinal plant leaf extract, Croton macrostachyus, loaded PCL electrospun nanofibrous mat as potential wound dressing: In vitro analysis","authors":"Adamu Biruk Fentahun, Gao Jing, Yuan Xiangnan, Tan Shaojie","doi":"10.1177/08839115241256950","DOIUrl":"https://doi.org/10.1177/08839115241256950","url":null,"abstract":"The main aim of this study was to investigate the potential application of an indiginous Ethiopian medicinal plant, Croton macrostachyus, into PCL nanofibers through electrospinning for the first time. Croton macrostachyus (CM) leaf has antibacterial and wound healing properties. Croton macrostachyus of 1%, 3%, 5%, and 7% (w/v) incorporated PCL nanofibrous mats were produced through electrospinning. The produced nanofibrous mats morphology observed by scanning electron microscopy (SEM) was found to be continuous, bead-free, and interconnected. The average diameters of PCL, PCL-1%CM, PCL-3%CM, PCL-5%CM, and PCL-7%CM nanofibrous mat is 309 ± 114, 271 ± 66, 235 ± 56, 226 ± 65, and 216 ± 42 nm, respectively. According to the FTIR results, the CM leaf extract was successfully incorporated into the PCL nanofibers. The bacterial reduction percentage value of PCL-1%CM, PCL-3%CM, PCL-5%CM, and PCL-7%CM nanofiber mats against S. aureus is 77.00%, 99.88%, 99.91%, and 99.99%, and 35.00%, 78.00%, 90.00%, and 99.30% against E. coli. The in vitro release study showed that there was an immediate release of CM within 24 h and then a steady sustained release of 51.36, 53.92, 54.99, and 57.12% up to 72 h at 1%, 3%, 5%, and 7% concentration, respectively. The presence of CM leaf extract in the PCL nanofiber increased the hydrophilicity of the pure PCL nanofiber (100% hydrophilic at 7% leaf extract concentration). In general, the results of the in vitro study confirmed that the PCL nanofibrous mats loaded with CM leaf extract are suitable for use as an effective wound dressing with a broad spectrum of antimicrobial activity and hydrophilic properties.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"22 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141151493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogels in biosensing and medical diagnostics 水凝胶在生物传感和医疗诊断中的应用

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-05-10 DOI: 10.1177/08839115241253260

Hossein Omidian, Sumana Dey Chowdhury, Arnavaz Akhzarmehr

{"title":"Hydrogels in biosensing and medical diagnostics","authors":"Hossein Omidian, Sumana Dey Chowdhury, Arnavaz Akhzarmehr","doi":"10.1177/08839115241253260","DOIUrl":"https://doi.org/10.1177/08839115241253260","url":null,"abstract":"This article presents an in-depth examination of recent advancements in medical and biotechnological sensing technologies, focusing on the forefront of innovation in hydrogel-based sensors within the domains of biomedical engineering and regenerative medicine. It delves into cutting-edge sensing technologies that facilitate non-invasive glucose monitoring, highlights progress in the development of intelligent solutions for wound care, and discusses the application of optical and fluorescence-based sensors for real-time diagnostics within the body. Further, it reviews the latest glucose monitoring devices, alongside wearable and implantable sensors designed for the continuous monitoring of health, including the measurement of physiological strain and stress. The exploration extends to the latest in non-invasive and minimally invasive technologies for ongoing health assessment, and to imaging and visualization techniques critical for medical diagnostics and therapeutic procedures. These advancements mark a pivotal move toward more efficient, precise, and patient-focused healthcare technologies, signaling new avenues for diagnosis, monitoring, and treatment in the healthcare sector.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"71 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140926199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the efficacy of catha edulis extract-loaded nanofibrous scaffolds seeded with bone marrow-derived stem cells for diabetic wound healing: A preclinical investigation 探究以骨髓干细胞为种子的鱼腥草提取物纳米纤维支架对糖尿病伤口愈合的疗效：临床前研究

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2024-04-26 DOI: 10.1177/08839115241248190

Yinsen Song, Sisen Zhang, Tianli Fan, Zhenzhen Yang, Peiliang Li, Lu Zhang, Na Gao, Wei Mei

{"title":"Exploring the efficacy of catha edulis extract-loaded nanofibrous scaffolds seeded with bone marrow-derived stem cells for diabetic wound healing: A preclinical investigation","authors":"Yinsen Song, Sisen Zhang, Tianli Fan, Zhenzhen Yang, Peiliang Li, Lu Zhang, Na Gao, Wei Mei","doi":"10.1177/08839115241248190","DOIUrl":"https://doi.org/10.1177/08839115241248190","url":null,"abstract":"Objectives:The aim of this study was to investigate the potential of incorporating catha edulis extract into polycaprolacton/gelatin scaffolds using electrospinning technique for the treatment of diabetic wounds in a rat model.Methods:The in vitro characterization of the scaffolds was performed using various assays, including anti-inflammatory assay, microstructure study, DPPH radical scavenging assay, cell viability assay, hemocompatibility assay, and bacterial penetration assays. The scaffolds were then seeded with bone marrow-derived stem cells and cultured before implantation into the rat model.Results:The results of the in vitro study showed that the produced scaffolds were nanofibrous, antioxidative, and non-toxic to skin cells. In vivo study demonstrated that the stem cell and catha edulis extract-loaded scaffolds had the highest rate of wound closure and histomorphometric parameters compared to other groups. Moreover, gene expression studies showed that the developed wound dressings increased the expression of VEGF gene and reduced the expression of glutathione peroxidase gene.Conclusion:These findings suggest that the catha edulis extract-loaded polycaprolacton/gelatin scaffolds could be a promising therapeutic option for diabetic wounds.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":"52 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140803022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0