Calendula officinalis extract-loaded conduits improved sciatic nerve injury repair through upregulation of BDNF and GFAP

IF 2.1 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Bioactive and Compatible Polymers Pub Date : 2024-06-22 DOI:10.1177/08839115241258150

Feng Xu, GuiBin Su

引用次数: 0

Abstract

In the current research, the nanofibrous neural channels were produced by electrospinning of PCL/Gelatin solution loaded with Calendula officinalis extract. The produced scaffolds properties were studied using various in vitro characterization methods. Then, the conduits’ healing potential was investigated in a rat model of PNS injury. In vitro results showed that scaffolds were not toxic and quenched DPPH free radicals. In addition, the extract-loaded conduits exhibited significant anti-inflammatory activity. In vivo study showed that the regular treadmill exercise significantly improved the healing efficacy of the Calendula officinalis-delivering conduits by upregulating BDNF and GFAP proteins.

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金盏花提取物负载导管通过上调 BDNF 和 GFAP 改善坐骨神经损伤修复

在当前的研究中，通过电纺丝技术将添加了金盏花提取物的 PCL/明胶溶液制成了纳米纤维神经通道。使用各种体外表征方法研究了所制支架的特性。然后，在大鼠神经管损伤模型中研究了导管的愈合潜力。体外实验结果表明，支架没有毒性，并能淬灭 DPPH 自由基。此外，含有提取物的导管还具有显著的抗炎活性。体内研究表明，通过上调 BDNF 和 GFAP 蛋白，定期进行跑步机运动可明显提高金盏花输送导管的愈合效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bioactive and Compatible Polymers 工程技术-材料科学：生物材料

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： The use and importance of biomedical polymers, especially in pharmacology, is growing rapidly. The Journal of Bioactive and Compatible Polymers is a fully peer-reviewed scholarly journal that provides biomedical polymer scientists and researchers with new information on important advances in this field. Examples of specific areas of interest to the journal include: polymeric drugs and drug design; polymeric functionalization and structures related to biological activity or compatibility; natural polymer modification to achieve specific biological activity or compatibility; enzyme modelling by polymers; membranes for biological use; liposome stabilization and cell modeling. This journal is a member of the Committee on Publication Ethics (COPE).