Development of cellulose-based films containing salicylic acid for wound dressing applications: Fabrication, properties and in vitro assessment

IF 2.1 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Bioactive and Compatible Polymers Pub Date : 2024-05-31 DOI:10.1177/08839115241253560

Mohd Ibnu Haikal Ahmad Sohaimy, Muhammad Amir Amzar Ismail, Azwani Sofia Ahmad Khiar, Norizah Mhd Sarbon, Nora Salina Md Salim, Hanis Nadia Yahya, Mohd Ikmar Nizam Mohamad Isa

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引用次数: 0

Abstract

A wound dressing is important to ensure an efficient healing process while protecting the wound area. This research study combined 2-hydroxyethyl cellulose (2HEC)—an etherified cellulose derivative with salicylic acid (SA) to develop a single layer and investigate the 2HEC viability as wound dressing material. Nine different samples with different compositions of SA, from 5 wt.% to 40 wt.% (with an interval of 5 wt.%) and one control sample without adding SA were prepared via the solution casting method. The 2HEC-SA films were studied regarding the effects of SA composition on antimicrobial properties ( Staphylococcus aureus) via the well-diffusion method. Additionally, degradability, mechanical properties, X-ray diffraction (XRD), and Fourier transform infrared (FTIR) of 2HEC-SA films have also been tested. The strongest antimicrobial effect of 2HEC-SA film was obtained at 40 wt.% with a 16 mm inhibition zone diameter. There was a noticeable decreasing weight loss pattern in the degradation test and the tensile strength of 2HEC-SA film when the composition of salicylic acid is increased. 2HEC-SA film changes phases from amorphous to crystalline starting at 25 wt.% of salicylic acid as seen through XRD, while FTIR shows that complexation of 2HEC and salicylic acid occurred at 1050 cm−1.

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开发用于伤口敷料的含水杨酸的纤维素基薄膜：制作、性能和体外评估

伤口敷料对于确保伤口有效愈合同时保护伤口区域非常重要。本研究将 2-羟乙基纤维素（2HEC）--一种醚化纤维素衍生物--与水杨酸（SA）相结合，开发出一种单层敷料，并研究了 2HEC 作为伤口敷料的可行性。研究人员通过溶液浇铸法制备了九种不同水杨酸成分的样品（从 5 wt.% 到 40 wt.%，间隔为 5 wt.%），以及一种不添加水杨酸的对照样品。通过井扩散法研究了 SA 成分对 2HEC-SA 薄膜抗菌性能（金黄色葡萄球菌）的影响。此外，还测试了 2HEC-SA 薄膜的降解性、机械性能、X 射线衍射 (XRD) 和傅立叶变换红外 (FTIR)。2HEC-SA 薄膜的抗菌效果在 40 wt.% 时最强，抑制区直径为 16 mm。当水杨酸成分增加时，2HEC-SA 薄膜的降解测试和拉伸强度都出现了明显的减重模式。通过 XRD 可以看出，从水杨酸含量为 25 wt.% 开始，2HEC-SA 薄膜的相位从无定形变为结晶，而傅立叶变换红外光谱显示，2HEC 和水杨酸在 1050 cm-1 处发生了络合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bioactive and Compatible Polymers 工程技术-材料科学：生物材料

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： The use and importance of biomedical polymers, especially in pharmacology, is growing rapidly. The Journal of Bioactive and Compatible Polymers is a fully peer-reviewed scholarly journal that provides biomedical polymer scientists and researchers with new information on important advances in this field. Examples of specific areas of interest to the journal include: polymeric drugs and drug design; polymeric functionalization and structures related to biological activity or compatibility; natural polymer modification to achieve specific biological activity or compatibility; enzyme modelling by polymers; membranes for biological use; liposome stabilization and cell modeling. This journal is a member of the Committee on Publication Ethics (COPE).