Journal of Bioactive and Compatible Polymers最新文献_第5页

Corrigendum to “Vancomycin coupled chitosan/PEO nanofibrous scaffold with the desired antibacterial activity as a potential for biomedical application” 万古霉素偶联壳聚糖/PEO纳米纤维支架在生物医学应用中的潜在抗菌活性

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-30 DOI: 10.1177/08839115231207193

引用次数: 0

Design and evaluation of moringa gum-based hydrogel dressings for cutaneous wound healing 辣木胶基水凝胶敷料用于皮肤伤口愈合的设计与评价

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-25 DOI: 10.1177/08839115231199700

Yasir Iqbal, Shahzad Ali Shahid Chatha, Zunera Chauhdary, Abdullah Ijaz Hussain, Ikram Ullah Khan

引用次数: 0

Levan-based bioactive hydrogels containing herbal liposome in treating acute wounds 含草药脂质体的以levan为基础的生物活性水凝胶治疗急性伤口

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-20 DOI: 10.1177/08839115231198528

Özlem Erdal Altıntaş, Pınar Aytar Çelik

{"title":"Levan-based bioactive hydrogels containing herbal liposome in treating acute wounds","authors":"Özlem Erdal Altıntaş, Pınar Aytar Çelik","doi":"10.1177/08839115231198528","DOIUrl":"https://doi.org/10.1177/08839115231198528","url":null,"abstract":"Hydrogels in active wound care products are 3D polymeric scaffolds that provide the desired moisture balance in the wound area with their high water retention capacity. Thanks to their biocompatible properties, flexible and porous structures, and high hydrophilic properties, they have frequently been preferred in the repair and regeneration of cells and tissues and the controlled release of bioactive substances to the target area. In this study, hydrogel structures were developed for the first time with levan produced by Halomonas elongata 153B halophilic bacteria. Extracts from Plantago lanceolata L., commonly known as a wound herb, which has medicinal importance for cell regeneration, ensuring tissue integrity in a short time and reducing infections in the wound area, were obtained and extract-loaded liposome structures were formed for controlled release into the wound area. The wound healing efficacy of the composite material developed by loading herbal liposomes into levan-based hydrogel structures was evaluated in an in vitro wound model. Thus, a natural, biocompatible, biodegradable, and functional wound care product containing herbal liposomes suitable for both clinical applications and point-of-care use has been developed. The developed bioactive hydrogels are a promising therapeutic approach for the healing of acute wounds. Graphical abstract [Formula: see text]","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136308953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the therapeutic effect of chitosan scaffolds loaded with the different concentrations of Hesperidin in bone regeneration in rat model 不同浓度橙皮苷负载壳聚糖支架对大鼠骨再生模型的疗效评价

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-01 DOI: 10.1177/08839115231198529

Mohadese Gharibblouk, Maryam Haji Ghasem Kashani, Meysam Nasiri, Arian Ehterami, Tayebeh Sadat Tabatabai, Majid Salehi

{"title":"Evaluation of the therapeutic effect of chitosan scaffolds loaded with the different concentrations of Hesperidin in bone regeneration in rat model","authors":"Mohadese Gharibblouk, Maryam Haji Ghasem Kashani, Meysam Nasiri, Arian Ehterami, Tayebeh Sadat Tabatabai, Majid Salehi","doi":"10.1177/08839115231198529","DOIUrl":"https://doi.org/10.1177/08839115231198529","url":null,"abstract":"Bone grafts are widely used to improve bone healing but this method is costly and make some serious problems like infection in long-term use. To solve these problems, tissue engineering by using scaffolds made of different materials can be used as a supportive structure to enhance bone healing. In the current study, 3-D chitosan (CS) bone scaffold was developed by freeze-drying techniques for bone tissue engineering. The efficiency of the CS scaffold was improved by loading different concentrations of Hesperidin (Hes). Scaffolds were characterized by different mechanical and biological tests to evaluate their properties. In addition, the effect of scaffolds on bone healing was evaluated by a rat femur defect model. Results showed that the porosity of scaffolds was about 45–257 µm and Hes has a negative effect on the mechanical strength of scaffolds. Also, due to the hydrophilic properties of Hes, the degradation rate increased. Histological and CT-Scan evaluation showed that the treated groups which scaffold loaded with 1% and 10% of Hes were fully replaced by new bone and collagenous matrix compared to control and Hesperidin (0%, 0.01%, 0.1%) treated groups. The Runx2 gene expression was significantly increased by 1% and 10% compared to other groups. These results showed the positive effect of the fabricated scaffold on osteogenesis and bone healing and the possibility of using it in clinical trials.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135347169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan and dextran hydrogel as a filler for possible application in orthopedic implantation surgery 壳聚糖和葡聚糖水凝胶作为填充材料在骨科植入术中的应用前景

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-01 DOI: 10.1177/08839115231195791

Abigail F Wu, Audrey L. Wu, T. Yeh, Pei-Chun Wong, Jia-Lin Wu

引用次数: 0

A double cross-linked hydrogel based on water-soluble chitosan and oxidized hyaluronic acid as an antibacterial dressing 以水溶性壳聚糖和氧化透明质酸为基础的双交联水凝胶作为抗菌敷料

4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-09-01 DOI: 10.1177/08839115231199697

Wenjun Shi, Quan Zhang, Lehan Du, Fan Xie, Junhao Shi, Liang Luan, Jiaju Lu, Xiangdong Kong

{"title":"A double cross-linked hydrogel based on water-soluble chitosan and oxidized hyaluronic acid as an antibacterial dressing","authors":"Wenjun Shi, Quan Zhang, Lehan Du, Fan Xie, Junhao Shi, Liang Luan, Jiaju Lu, Xiangdong Kong","doi":"10.1177/08839115231199697","DOIUrl":"https://doi.org/10.1177/08839115231199697","url":null,"abstract":"Quaternary ammonium chitosan (QCS) is a cationic polymer with high antimicrobial properties, but its cations can cause damage to normal cells. Thus, the biocompatibility of QCS in hydrogel dressings should be concerned. In this study, QCS was used as an additive in the preparation of the carboxymethyl chitosan (CMC) and oxidized hyaluronic acid (OHA) hydrogel, and the effect of its content in the hydrogel on antibacterial and biocompatibility was systematically investigated. First, QCS was mixed at a different ratio with CMC to form a QCS/CMC solution. Then, the QCS/CMC solution was added into the OHA solution to obtain the OHA-CMC/QCS hydrogel, which is a double cross-linked network formed by the Schiff base and electrostatic interaction. With the increase of the QCS content in the hydrogel, its mechanical and antibacterial properties were enhanced. The antibacterial rate of OHA-CMC/QCS5 hydrogel with 5% QCS content against Staphylococcus aureus reached 99.80%, and it also showed biocompatibility under the experimental conditions. This work provides a theoretical basis for the use of QCS to prepare the hydrogels that are both antibacterial and biocompatible. The prepared OHA-CMC/QCS5 hydrogel is an ideal candidate for antimicrobial dressings.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135388300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vancomycin coupled chitosan/PEO nanofibrous scaffold with the desired antibacterial activity as a potential for biomedical application 万古霉素偶联壳聚糖/PEO纳米纤维支架具有良好的抗菌活性，具有潜在的生物医学应用前景

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-08-26 DOI: 10.1177/08839115231195796

A. Gholami, Ali Rahmanian, E. Mirzaei, Fatemeh Mozaffariyan, K. Asadi, N. Omidifar

{"title":"Vancomycin coupled chitosan/PEO nanofibrous scaffold with the desired antibacterial activity as a potential for biomedical application","authors":"A. Gholami, Ali Rahmanian, E. Mirzaei, Fatemeh Mozaffariyan, K. Asadi, N. Omidifar","doi":"10.1177/08839115231195796","DOIUrl":"https://doi.org/10.1177/08839115231195796","url":null,"abstract":"This study aims to evaluate the Vancomycin (VCM) combination with Chitosan (CS)/ Polyethylene oxide (PEO) nanofibers’ intrinsic antibacterial properties causing a synergistic effect against possible serious bacterial infections (PSBI). VCM/CS nanofiber scaffold was fabricated using the electrospinning method. Characterizations are performed by Fourier transform infrared (FT-IR) to examine the functional groups of each compound, scanning electron microscopy (SEM), and transient electron microscopy (TEM) to evaluate nanofiber diameter and structure. Antibacterial activities of the nanofibrous scaffold were assessed against bacterial strains, including standard Staphylococcus aureus ( S. aureus), VCM-sensitive Enterococcus (VSE), methicillin-resistant S. aureus (MRSA), VCM-resistant Enterococcus (VRE), and Streptococcus group A by microdilution broth methods. The FT-IR, SEM, and TEM examination results confirm the CS/PEO nanofiber scaffold fabrication. The antibacterial examination results showed no significant difference between the minimum inhibitory concentration (MIC) values of VCM and with MIC of VCM/CS nanofibers. Still, there were significant differences between the MIC of CS and VCM/CS nanofibers in S. aureus, but this is not more significant than VCM. This study illustrated that VCM coupled to CS nanofibers had acceptable antibacterial activity against the Gram-positive bacterium. This work motivated researchers’ insight into nanostructures’ potential accompanied by antibacterial polymer and antibiotics synergistic effects against PSBI.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84193552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomineralization of carboxymethyl cellulose-sodium alginate infused with cellulose nanocrystals for bone regeneration 羧甲基纤维素-海藻酸钠注入纤维素纳米晶体用于骨再生的生物矿化

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-07-13 DOI: 10.1177/08839115231185762

E. Bakhiet, Nur Fatini Ilyana Mohamat Johari, Fathima Shahitha Jahir Hussain, Farah Hanani Zulkifli

{"title":"Biomineralization of carboxymethyl cellulose-sodium alginate infused with cellulose nanocrystals for bone regeneration","authors":"E. Bakhiet, Nur Fatini Ilyana Mohamat Johari, Fathima Shahitha Jahir Hussain, Farah Hanani Zulkifli","doi":"10.1177/08839115231185762","DOIUrl":"https://doi.org/10.1177/08839115231185762","url":null,"abstract":"The development of novel tissue constructs from both natural and synthetic biopolymers has attracted widespread attention among researchers, prior to its excellent outcomes in bone tissue regeneration. This research aims to investigate the biocompatibility of carboxymethyl cellulose (CMC)/sodium alginate (SA) embedded with cellulose nanocrystals (CNC) and its surface response due to the biomineralization process as potential implant material. The CMC/SA were prepared with and without CNC using water as the only solvent. It was then freeze-dried for up to 72 h before being further immersed in simulated body fluid (SBF) for comparative studies. Morphological observation by scanning electron microscope (SEM) showed that CMC/SA/CNC (SBF) displayed a spherical apatite structure amid interconnected porous materials with an average particle diameter between 95 and 148 nm. The apatite crystal indicated the existence of calcium (Ca) and phosphorus (P) elements, which was confirmed by energy dispersive X-ray analysis (EDX). All scaffolds showed a porosity of up to 90.13% with a moderate degradation rate and a water absorption value of up to 1100%. Overall, all scaffolds had open, interconnected pore sizes ranging from 40 to 400 µm. Attenuated total reflection – Fourier Transform Infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA) curve showed a new existing peak and lower decomposition rate, respectively, for SBF-treated scaffolds. Stress-strain curve disclosed the highest tensile stress of CMC/SA/CNC (SBF) at 16.2 MPa and 15.75% strain effect. Preliminary in vitro cytotoxicity studies performed with human foetal osteoblast (hFOB) cells showed that cytocompatibility was more evident on CMC/SA/CNC (SBF) scaffolds. This study showed that scaffold-embedded CNC with SBF treatment could be hit upon as material selection for bone tissue engineering.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87674098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and evaluation of chitosan-alginate/carrageenan hydrogel for oral drug delivery in the treatment of diabetes 壳聚糖-海藻酸盐/卡拉胶水凝胶治疗糖尿病口服给药的制备及评价

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-06-27 DOI: 10.1177/08839115231183487

Archana George, P. Shrivastav

{"title":"Preparation and evaluation of chitosan-alginate/carrageenan hydrogel for oral drug delivery in the treatment of diabetes","authors":"Archana George, P. Shrivastav","doi":"10.1177/08839115231183487","DOIUrl":"https://doi.org/10.1177/08839115231183487","url":null,"abstract":"Marine beds are an untapped resource of bioactive materials which can be explored for drug delivery applications. In the present study, a hydrogel was developed with an optimal concentration of sodium alginate-chitosan core polyelectrolytic complex loaded with anti-diabetic drug metformin and coated with ĸ-Carrageenan as an efficient oral drug delivery vehicle. The formulation was optimized by changing parameters such as concentration of polymers, amount of cross-linker and the type and amount of coating material. The prepared hydrogels were characterized for their structural integrity using instrumental techniques such as FTIR, XRD, DSC, and SEM while the physical properties were assessed by evaluating its thickness, UV barrier ability and swelling degree. In vitro study demonstrated the influence of presence and type of coating material affecting drug delivery process. The study suggested that coating with 3% ĸ-Carrageenan (A19) was found most suitable for oral drug delivery since it could resist diffusion of drug in the stomach (pH 1.2) so that maximum drug could reach the intestine (pH 7.4) for absorption. Metformin loaded hydrogel (A20) released ~49% drug in the simulated gastric fluid (pH 1.2). In the simulated intestinal fluid (pH 7.4) both the hydrogel exhibited a sustained release pattern lasting for more than 4 h. Investigation of drug release kinetics using different mathematical models showed that Higuchi model was the best fit release model with R2 ⩾ 0.973. The results indicated that the prepared hydrogels could be potential drug delivery vehicle toward intestine as well as for extended release to colon targeted drug delivery.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85850649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preparation and characterization of sodium alginate/Antarctic krill protein/Genipin scaffold for skin tissue engineering 海藻酸钠/南极磷虾蛋白/Genipin皮肤组织工程支架的制备与表征

IF 1.7 4区生物学

Journal of Bioactive and Compatible Polymers Pub Date : 2023-06-13 DOI: 10.1177/08839115231180020

Jianbing Sun, Jingjing Guo, Yan Wang, Jicheng Shan, Juhui Yin, Zheng Cao

{"title":"Preparation and characterization of sodium alginate/Antarctic krill protein/Genipin scaffold for skin tissue engineering","authors":"Jianbing Sun, Jingjing Guo, Yan Wang, Jicheng Shan, Juhui Yin, Zheng Cao","doi":"10.1177/08839115231180020","DOIUrl":"https://doi.org/10.1177/08839115231180020","url":null,"abstract":"In this study, sodium alginate (SA)/Antarctic krill protein(AKP)/Genipin (GP) scaffold was obtained by freeze-drying, in which Antarctic krill protein was used as enhanced the cell adsorption activity of the materials; GP and Ca2+, which have very low cytotoxicity, were selected to cross-link AKP and SA in steps, the interpenetrating network structure of “covalent cross-linking-ion complex-hydrogen bonding” was finally constructed. By changing the content of GP, the structure, surface morphology, mechanical properties, water absorption, water retention, and cytotoxicity of the scaffold were studied using FTIR, SEM, and other test methods. The results showed that the pore area of the prepared SA/AKP/GP scaffolds exhibited an increase and then a decrease with the increase of GP content; the fracture strength and elongation at break exhibited an increase and then a decrease with the increase of GP content. The breaking strength and elongation at break achieved their maximum values of 32.9 MPa and 4.43% when the content of GP hit 0.8%; The scaffold had good water absorption and water retention; The cytotoxicity grade of the scaffold was grade 0, and the addition of AKP made the fibroblasts have good growth and proliferation ability on the scaffold.","PeriodicalId":15038,"journal":{"name":"Journal of Bioactive and Compatible Polymers","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79243694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0