Journal of Advances in Medicine Science最新文献

{"title":"Evaluation on the Influence of the Timing of Twin Pregnancy Termination on the Outcome of Mother and Infants","authors":"Yuying Chen","doi":"10.30564/JAMS.V4I2.3035","DOIUrl":"https://doi.org/10.30564/JAMS.V4I2.3035","url":null,"abstract":"Objective: To observe the maternal and infant outcomes of pregnant women with twins terminating their pregnancy at different timings.  Methods: Among the twin pregnant women admitted to our hospital from August 2019 to August 2020, 50 primiparous women who opted to terminate their pregnancies at 5 different timings of “34——34+6 weeks”, “35——35+6 weeks”, “36——36+6 weeks”, “37——37+6 weeks”, “38——38+6 weeks” were selected as the research subjects. According to the timing of pregnancy termination, they were divided into 5 groups, each with 10 cases of pregnant women, and the impact of the timing of pregnancy termination on the outcome of the mothers and infants were compared.  Results: The “37——37+6 weeks” group had the largest amount of postpartum hemorrhage, and the difference in Hb level before and after delivery was the largest. With the increase in gestational week, the weight of both large and small fetuses increased. In terms of neonatal diseases, the comparison between “34——34+6 weeks”, “35——35+6 weeks”, “36——36+6 weeks” and “37——37+6 weeks”, “38——38+6 weeks”, P＜0.05, the comparison between “37——37+6 weeks” and “38——38+6 weeks”, P>0.05.  Conclusion: The extension of the gestational week of twin pregnancies has no effect on postpartum hemorrhage, but it can improve the outcome of infants.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90355742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Metformin on Lactate Metabolism in Normal Hepatocytes under High Glucose Stress in Vitro","authors":"Xinxin Zhou, Xinliang Liu, Ling Zhang, Yong-jing Chen, Shao-Chen Guo, Yiying Yu, Zhilu Li, Pingping Yan","doi":"10.30564/JER.V3I1.2864","DOIUrl":"https://doi.org/10.30564/JER.V3I1.2864","url":null,"abstract":"Objective: To study the effect of metformin on lactate metabolism in hepatocytes in vitro under high glucose stress. Method: LO2 hepatocytes was cultured in vitro, hepatocytes were randomly divided into blank control group, 25 mmol/L glucose solution, 27 mmol/L glucose solution, 29 mmol/L glucose solution, 31 mmol/L glucose solution, 33 mmol/L glucose solution, 35 mmol/L glucose solution treatment group, after determining the optimal concentration as 31 mmol/L, use 30 mmol/L metformin solution, and then divided into blank control group, normal hepatocytes + the optimal concentration of glucose solution, normal hepatocytes + metformin solution , normal hepatocytes+. The optimal concentration of glucose solution normal hepatocytes + metformin solution, calculate the number of hepatocytes on cell count plate respectively in the 12 h, 24 h, 48 h, and use the lactic acid kit to determine the lactic acid value of the cell culture medium of normal liver cells + optimal concentration glucose solution and normal liver cells + optimal concentration glucose solution + metformin solution at 12 h, 24 h, and 48 h, respectively. Results: There was no significant change in the lactic acid concentration but significant increase in the number of surviving hepatocytes in the high-glycemic control group compared with that in the high-glycemic control group without metformin. Conclusions: Metformin has no significant effect on lactic acid metabolism of hepatocytes under high glucose stress in vitro, and has a protective effect on hepatocytes under high glucose stress. Based on this, it is preliminarily believed that metformin is not the direct factor leading to diabetic lactic acidosis.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86228767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of miR-21 in Colorectal Cancer and Its Relationship with Clinicopathological Characteristics of Colorectal Cancer","authors":"Jia Lei","doi":"10.30564/jams.v3i3.1639","DOIUrl":"https://doi.org/10.30564/jams.v3i3.1639","url":null,"abstract":"Objective: To investigate the expression of miR-21 in colorectal cancer cells, and to analyze the relationship between the level of miR-21 and the clinicopathological characteristics of colorectal cancer patients. Methods: 210 patients with colorectal cancer treated in our hospital from January 2016 to June 2019 were selected. Cancer tissue specimens (study group) and adjacent normal tissue specimens (control group) were surgically collected, and the quantitative quantitative PCR was used to detect and compare the miR-21 expression of the two groups. Results: The expression of miR-21 in the study group was higher than that in the control group, and the difference was statistically significant (P <0.05). There were significant differences among patients with early and intermediate TNM, patients with low differentiation and patients with moderate to high differentiation, patients with lymph node metastasis and patients without lymph node metastasis, patients with high infiltration and patients with low infiltration, patients with high CEA levels, and patients with low CEA, and the difference was statistically significant (P <0.05). Conclusion: In colorectal cancer, miR-21 is highly expressed, which is closely related to stage and differentiation, and can be used to reflect the patient’s condition.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79519383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of miR-21 in Colorectal Cancer and Its Relationship with Clinicopathological Characteristics of Colorectal Cancer","authors":"佳 雷","doi":"10.30564/jams.v4i1.1756","DOIUrl":"https://doi.org/10.30564/jams.v4i1.1756","url":null,"abstract":"Expression of miR-21 in Colorectal Cancer and Its Relationship with Clinicopathological Characteristics of Colorectal Cancer","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77206910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Detection of Mean Platelet Volume and Immunoglobins as a Strategy for the Diagnosis of Systemic Lupus Erythematosus","authors":"Changzhi Xu, Zhizhi Xie, Yanhua Yi, Donglin Zhu, Yun Xi","doi":"10.30564/jams.v2i4.1228","DOIUrl":"https://doi.org/10.30564/jams.v2i4.1228","url":null,"abstract":"Objective:To explore the possibility of diagnosing and monitoring patients with systemic lupus erythematosus (SLE) using the combination of mean platelet volume (MPV) and routine immunoglobulin test. Method:116 patients with SLE were divided into 3 groups according to their clinical characteristics, including 29 patients with renal impairment, 44 cases of active stage and 43 cases of inactive patients. 40 healthy subjects were randomly selected as controls. Subjects were tested for routine blood test and plasma Immunoglobins, such as IgG, IgA, IgM, C3, C4, CH50, CRP. The results were analyzed and the characteristics of each group of subjects were determined, the correlation between test results and diagnosis were studied. Result: In comparison to the control group, the serum level of MPV, C3 and C4 were decreased (P<0.05), and C reactive protein level was elevated (P<0.001) in the three groups of SLE patients. The IgG level in active and inactive SLE patients was increased (P<0.0001), CH50 level was decreased in patients with inactive SLE (P<0.05), IgA level of active SLE subjects was found to be elevated (P<0.05), IgM in patients with renal impairment was decreased (P<0.05). Other than that, no other significant characteristic were found. Conclusion: The pathogenesis of SLE is a complex process involving multiple factors. The changes of MPV, IgG, IgA, IgM, C3, C4, CH50 and CRP in SLE patients are characteristic parameters. The combination of the above indicators can help to determine the diagnosis and staging of SLE. The timely diagnosis and treatment of SLE patients has important clinical significance in protecting the organ function of SLE patients and improving the prognosis.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90254345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Antibacterial Activity of Galla Chinensis Combined with Different Antibacterial Drugs against Carbapenem-Resistant E.Coli","authors":"Zhizhi Xie, Changzhi Xu, Yanhua Yi, Donglin Zhu, Yun Xi","doi":"10.30564/jams.v2i4.1229","DOIUrl":"https://doi.org/10.30564/jams.v2i4.1229","url":null,"abstract":"Objective: To evaluate the antibacterial effects of meropenem and levofloxacin respectively combined with Galla chinensis on carbapenem-resistant Escherichia coli in vitro. Methods： The protocol was designed with checkerboard method and the carbapenem-resistant E.coli was isolated in our hospital. The minimum inhibitory concentrations(MICs) of G. chinensis alone and combined with 2 antimicrobial agents against carbapenem-resistant E.coli were determined by broth dilution method and the fractional inhibitory concentration index (FICI) was calculated according to MICs results. Result： the combined use of G. chinensis and meropenem (or levofloxacin) significantly decreased both MIC50 and MIC90; After the combination of G. chinensis and meropenem, the synergistic effect was 86.7%, and the additive effect was 13.3%, no irrelevant and antagonistic effects. After combined use of G. chinensis and levofloxacin, the synergistic effect was 66.7%, and the additive effect was 33.3%. No irrelevant and antagonistic effects. Conclusion： Galla chinensis combined with meropenem or levofloxacin has synergistic and additive antibacterial effect, with certain combined antibacterial activity.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81114661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration and Discussion on Drug Management in the Operating Room","authors":"Jin-hong Ma","doi":"10.30564/jams.v2i4.1230","DOIUrl":"https://doi.org/10.30564/jams.v2i4.1230","url":null,"abstract":"Operating room drug management work directly related to the safety of medication and the scientific nature of medication, the most important content of operating room drug management is to ensure the rational and safe use of drugs, to avoid drug abuse and misuse. This paper mainly explores the problems existing in the current operating room drug management process, points out the specific drug management model, and hopes to give full play to the role of drug management to ensure that drugs can be applied scientifically.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74422458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Distribution and Drug Resistance of 224 Strains of Pseudomonas Aeruginosa","authors":"Zhizhi Xie, Changzhi Xu, Donglin Zhu, Yun Xi","doi":"10.30564/jams.v2i4.1212","DOIUrl":"https://doi.org/10.30564/jams.v2i4.1212","url":null,"abstract":"Objective: To provide evidence for a rational and effective prevention and treatment of Pseudomonas aeruginosa, the clinical characteristics and the resistance to various antibiotics of were investigated.Methods：A retrospective analysis of 224 strains of Pseudomonas aeruginosa isolated from various specimens from various clinical departments of our hospital (April 1, 2018 to June 31, 2019) were conducted. Identification and drug susceptibility test of isolated strains was performed using a fully automatic bacterial identification analyzer (MicroScan WalkAway-96 plus), and data analysis was performed using WH0NET5.6 software. Result：Among all the bacteria isolated in our hospital during the above period, Pseudomonas aeruginosa accounted for 10.09% of them all and 12.57% of Gram-negative bacilli, respectively. These isolates were mainly derived from sputum specimens (68.75%), mainly from male patients (70.54%), and mostly 61-70 (27.23%) or 51-60 (22.77%) years old. Pseudomonas aeruginosa isolates are mainly from Rehabilitation Ward, ICU, and Liver Transplantation Unit, accounted for 29.91%, 12.95% and 10.27% of all isolates, respectively. The sensitivity of Pseudomonas aeruginosa to various antibacterial drugs, in the order of high to low were carbapenems, aztreonam, quinolones, cephalosporins, piperacillin/ tazobactam, aminoglycoside, with a lowest resistance rate (2.4%) to amikacin and a highest resistance rate to imipenem (33.0%). Conclusion：The isolation rate of Pseudomonas aeruginosa was relatively stable during the study period, and among all the P. aeruginosa detected, most of them were from the respiratory secretions of elderly male patients. The resistance rate of Pseudomonas aeruginosa isolates to various antibiotics is mainly within 30%. Clinical units such as Rehabilitation Ward, ICU, and Liver Transplantation Unit have a high detection rate, therefore, these departments should be monitored in a focused manner. Our research provide a scientific basis for the rational use of antibiotics and a better control of Pseudomonas aeruginosa infection.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73844417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Exploration of the Clinical Treatment of Chronic Atrophic Gastritis","authors":"Eerdunbagena Ning","doi":"10.30564/jams.v2i4.1118","DOIUrl":"https://doi.org/10.30564/jams.v2i4.1118","url":null,"abstract":"Purpose: To explore the effect of the clinical treatment of chronic atrophic gastritis Method: 70 patients with chronic atrophic gastritis treated in our hospital from October 2017 to November 2018 were selected and randomly divided into an observation group and a control group with 35 patients in each group. The control group received standard triad treatment with gastroprokinetic drug orally. On the basis of the control group, patients in the observation group received Xianlu Pazhu Wan. The treatment efficiency, eradication rate of helicobacter pylori (H. pylori), incidence of adverse effects and length of stay were compared between the two groups. Result: Compared with the control group, patients in the observation group had a higher treatment efficiency, higher H. pylori eradication rate, lower incidence of adverse effects, and shorter length of stay with statistical significance (P< 0.05). Conclusion: In the clinical treatment of patients with chronic atrophic gastritis, adding Xianlu Pazhu Wan into the basic medication plan can have a better treatment efficiency, reduce the incidence of adverse effects, and shorten the length of stay. Therefore, Xianlu Pazhu Wan should be promoted in the practice. ","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80197041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief Talking about the Development of Medical Device Industry in China","authors":"Y. Bao","doi":"10.30564/jams.v2i4.1030","DOIUrl":"https://doi.org/10.30564/jams.v2i4.1030","url":null,"abstract":"With the continuous development of China's economy and the improvement of Chinese’ living standards, people's awareness of health care has gradually increased, so the demand for medical devices products is also strengthen. In addition, China is gradually entering an aging society and policy support for the medical device industry. China's medical device industry is developing rapidly.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"19 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91507865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}