Expression of miR-21 in Colorectal Cancer and Its Relationship with Clinicopathological Characteristics of Colorectal Cancer

Jia Lei
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Abstract

Objective: To investigate the expression of miR-21 in colorectal cancer cells, and to analyze the relationship between the level of miR-21 and the clinicopathological characteristics of colorectal cancer patients. Methods: 210 patients with colorectal cancer treated in our hospital from January 2016 to June 2019 were selected. Cancer tissue specimens (study group) and adjacent normal tissue specimens (control group) were surgically collected, and the quantitative quantitative PCR was used to detect and compare the miR-21 expression of the two groups. Results: The expression of miR-21 in the study group was higher than that in the control group, and the difference was statistically significant (P <0.05). There were significant differences among patients with early and intermediate TNM, patients with low differentiation and patients with moderate to high differentiation, patients with lymph node metastasis and patients without lymph node metastasis, patients with high infiltration and patients with low infiltration, patients with high CEA levels, and patients with low CEA, and the difference was statistically significant (P <0.05). Conclusion: In colorectal cancer, miR-21 is highly expressed, which is closely related to stage and differentiation, and can be used to reflect the patient’s condition.
miR-21在结直肠癌中的表达及其与结直肠癌临床病理特征的关系
目的:研究miR-21在结直肠癌细胞中的表达情况,分析miR-21水平与结直肠癌患者临床病理特征的关系。方法:选取2016年1月至2019年6月在我院治疗的结直肠癌患者210例。手术采集癌组织标本(研究组)和邻近正常组织标本(对照组),采用定量定量PCR检测并比较两组miR-21的表达。结果:研究组miR-21的表达高于对照组,差异有统计学意义(P <0.05)。早期与中期TNM患者、低分化患者与中高分化患者、淋巴结转移患者与无淋巴结转移患者、高浸润患者与低浸润患者、CEA高水平患者与CEA低水平患者的差异均有统计学意义(P <0.05)。结论:在结直肠癌中,miR-21高表达,与分期、分化密切相关,可用于反映患者病情。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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