Journal of Alzheimer's Disease最新文献_第5页

Cognitive care at your fingertips: A systematic review of telemedicine potential and barriers in rehabilitation for dementia. 指尖上的认知护理：对痴呆症康复中远程医疗潜力和障碍的系统回顾。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1177/13872877251365565

Andrea Calderone, Angela Marra, Desirèe Latella, Paolo De Pasquale, Loris Pignolo, Maria Grazia Maggio, Rocco Salvatore Calabrò

{"title":"Cognitive care at your fingertips: A systematic review of telemedicine potential and barriers in rehabilitation for dementia.","authors":"Andrea Calderone, Angela Marra, Desirèe Latella, Paolo De Pasquale, Loris Pignolo, Maria Grazia Maggio, Rocco Salvatore Calabrò","doi":"10.1177/13872877251365565","DOIUrl":"10.1177/13872877251365565","url":null,"abstract":"BackgroundDementia is characterized by a deterioration in cognitive functions that impacts everyday tasks and overall life quality, with Alzheimer's disease (AD) being the most prevalent form. As dementia progresses, cognitive rehabilitation, often utilized in conjunction with telemedicine, offers significant support via targeted interventions that enhance autonomy and overall quality of life (QoL).ObjectiveThis systematic review aims to explore the potential and barriers of telemedicine-based cognitive stimulation and training programs for individuals with dementia and mild cognitive impairment (MCI).MethodsStudies were identified from an online search of PubMed, Web of Science, Embase, PsychINFO, and Scopus databases conducted up to 19 February 2025. This systematic review has been registered on PROSPERO under the following number: CRD42024615619.ResultsThe studies establish that digital health interventions and telehealth approaches add to the improvement in cognitive rehabilitation among patients with dementia and MCI, by indicating striking improvements not only in cognitive functioning but also in increased support for caregivers. The higher adherence and satisfaction rates with such interventions can be attributed to telemedicine itself and newer technologies such as virtual reality (VR) and transcranial direct current stimulation, which can provide options for personalized and accessible care in neurodegenerative disease management.ConclusionsTelemedicine-based cognitive rehabilitation in dementia patients, not only achieves improved cognitive functioning but also a better QoL and reduced caregiver burden. Further studies are needed to ensure equal implementation and long-term sustainability of these interventions, possibly with the inclusion of newer technologies such as VR and neuromodulation.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"910-959"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of plastic-associated chemicals with Alzheimer's disease amyloid-β and cognitive status. 塑料相关化学物质与阿尔茨海默病淀粉样蛋白β和认知状态的关联。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-03 DOI: 10.1177/13872877251364559

Rodrigo Canovas, James D Doecke, Christopher J Fowler, Jurgen Fripp, Xianyu Wang, Jochen F Mueller, Ayomi Jayarathne, Chang He, Ahmed Elagali, Sarah Dunlop, Colin L Masters

引用次数: 0

Linking genetics to MRI-DTI: HFE polymorphism delays Alzheimer's disease white matter degeneration in APOE4 carriers. 将遗传与MRI-DTI联系起来：HFE多态性延缓APOE4携带者的阿尔茨海默病白质变性。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-03 DOI: 10.1177/13872877251363211

Ran Pang, Jianli Wang, Samika Kanekar, Prasanna Karunanayaka, Gela Beselia, Sangam Kanekar, Mark Meadowcroft, James R Connor, Qing X Yang

{"title":"Linking genetics to MRI-DTI: HFE polymorphism delays Alzheimer's disease white matter degeneration in APOE4 carriers.","authors":"Ran Pang, Jianli Wang, Samika Kanekar, Prasanna Karunanayaka, Gela Beselia, Sangam Kanekar, Mark Meadowcroft, James R Connor, Qing X Yang","doi":"10.1177/13872877251363211","DOIUrl":"10.1177/13872877251363211","url":null,"abstract":"BackgroundWhile APOE4 mutation impacts normal myelination through disruptions of iron and lipid homeostasis, the HFE (homeostatic iron regulatory gene) polymorphism directly participates in white matter (WM) myelination and neuroinflammations processes via modulating iron homeostasis.ObjectiveThis study investigated effects of HFE polymorphism in APOE4 gene carriers in the context of WM degeneration and neuroinflammation in Alzheimer's disease (AD).MethodsWM degeneration in AD subjects of APOE4 carriers with and without HFE H63D polymorphism was evaluated and compared with age- and sex-matched cognitive normal (CN) groups using diffusion tensor imaging (DTI) data from the Alzheimer's Disease Neuroimaging Initiative database.ResultsDTI radial and mean diffusivity demonstrated an extensive and precipitous age-related WM degeneration in all the AD groups compared to the CN cohorts. This AD-related WM degeneration, however, was significantly attenuated with HFE H63D polymorphism than that of wildtype along with reduced cognitive decline in the AD group. To link the observed protective effect of HFE H63D polymorphism to WM degeneration and cognitive decline in AD, a mediation model was developed and verified using structure equation modeling. This protective effect of HFE H63D polymorphism on WM is also associated with higher cerebrospinal fluid sTREM2 level.ConclusionsThis is the first genetic-to-imaging study linking HFE polymorphism to WM degeneration and consequentially to cognitive declines in AD. Our data provide original information on the role of iron homeostasis specifically in WM degeneration, which suggests that manipulating iron homeostasis could be incorporated into the overall AD prevention and intervention strategies.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1114-1128"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A brain health framework with application to the study of neurodegeneration. 脑健康框架及其在神经变性研究中的应用。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-04 DOI: 10.1177/13872877251364867

Simon Duchesne, Olivier Potvin, Carol Hudon, Christian Bocti

{"title":"A brain health framework with application to the study of neurodegeneration.","authors":"Simon Duchesne, Olivier Potvin, Carol Hudon, Christian Bocti","doi":"10.1177/13872877251364867","DOIUrl":"10.1177/13872877251364867","url":null,"abstract":"An all-encompassing framework seems necessary for understanding brain health in the context of neurodegeneration, particularly due to Alzheimer's disease (AD). We argue that current views, dominated by the amyloid-beta hypothesis, oversimplify the complexity of brain degeneration. We propose a multi-scale, multi-entity approach, treating the brain as a complex system composed of interacting subsystems across various scales, from the nanoscale (genes and proteins) to the macroscale (cognition) and beyond. By redefining brain health through mathematical complexity, we emphasize the importance of integrating diverse biological, environmental, and lifestyle factors to account for the heterogeneity in AD presentations. This framework suggests that failures at different levels of brain function can lead to cascading effects that influence neurodegenerative trajectories. Additionally, it calls for a shift toward personalized treatment approaches that target multiple yet specific pathological mechanisms affecting an individual. We propose computational models as essential tools for simulating and testing these complex interactions. Through this framework, we aim to provide a deeper understanding of neurodegeneration, and advocate for more comprehensive and multi-factorial approaches in both research and clinical practice to advance the treatment of brain health disorders such as AD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"960-972"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in white matter amplitude of low-frequency fluctuation associated with cognitive performance across the Alzheimer's disease continuum. 在阿尔茨海默病连续体中，与认知表现相关的低频波动白质振幅的性别差异。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1177/13872877251364722

Xiao Chen, Shanshan Zhou, Wenrui Wang, Ziwen Gao, Wei Ye, Wanqiu Zhu, Yun Lu, Ju Ma, Xiaohu Li, Yongqiang Yu, Xiaoshu Li

{"title":"Sex differences in white matter amplitude of low-frequency fluctuation associated with cognitive performance across the Alzheimer's disease continuum.","authors":"Xiao Chen, Shanshan Zhou, Wenrui Wang, Ziwen Gao, Wei Ye, Wanqiu Zhu, Yun Lu, Ju Ma, Xiaohu Li, Yongqiang Yu, Xiaoshu Li","doi":"10.1177/13872877251364722","DOIUrl":"10.1177/13872877251364722","url":null,"abstract":"BackgroundSex differences in Alzheimer's disease (AD) progression offer insights into pathogenesis and clinical management. White matter (WM) amplitude of low-frequency fluctuation (ALFF), reflecting neural activity, represents a potential disease biomarker.ObjectiveTo explore whether there are sex differences in regional WM ALFF among AD patients, amnestic mild cognitive impairment (aMCI) patients, and healthy controls (HCs), how it is related to cognitive performance, and whether it can be used for disease classification.MethodsResting-state functional magnetic resonance images and cognitive assessments were obtained from 85 AD (36 female), 52 aMCI (23 female), and 78 HCs (43 female). Two-way ANOVA examined group × sex interactions for regional WM ALFF and cognitive scores. WM ALFF-cognition correlations and support vector machine diagnostic accuracy were evaluated.ResultsSex × group interaction effects on WM ALFF were detected in the right superior longitudinal fasciculus (F = 20.08, pFDR_corrected < 0.001), left superior longitudinal fasciculus (F = 5.45, pGRF_corrected < 0.001) and right inferior longitudinal fasciculus (F = 6.00, pGRF_corrected = 0.001). These WM ALFF values positively correlated with different cognitive performance between sexes. The support vector machine learning best differentiated aMCI from AD in the full cohort and males (accuracy = 75%), and HCs from aMCI in females (accuracy = 93%).ConclusionsSex differences in regional WM ALFF during AD progression are associated with cognitive performance and can be utilized for disease classification.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1026-1037"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Danish Dementia Research Centre: Integrating patient care, clinical research, and national educational services. 丹麦痴呆症研究中心：整合病人护理、临床研究和国家教育服务。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1177/13872877251365195

Steen Gregers Hasselbalch, Birgitte Bo Andersen, Patrick Ejlerskov, Kristian Steen Frederiksen, Jørgen Erik Nielsen, Thomas Rune Nielsen, Anja Hviid Simonsen, Asmus Vogel, Gunhild Waldemar

{"title":"The Danish Dementia Research Centre: Integrating patient care, clinical research, and national educational services.","authors":"Steen Gregers Hasselbalch, Birgitte Bo Andersen, Patrick Ejlerskov, Kristian Steen Frederiksen, Jørgen Erik Nielsen, Thomas Rune Nielsen, Anja Hviid Simonsen, Asmus Vogel, Gunhild Waldemar","doi":"10.1177/13872877251365195","DOIUrl":"10.1177/13872877251365195","url":null,"abstract":"The Copenhagen Memory Clinic was established in 1995 and since 2007 a new national center for research and education was established, together forming the Danish Dementia Research Centre (DDRC). Our research and innovation programs have continuously been informed by clinical experience and inspired by the needs of our patients. The link between patient care, research, and education forming together a comprehensive dementia center is therefore of crucial importance. In this review, we present an overview of the clinical program at the Copenhagen Memory Clinic, currently receiving 2.000 new referrals per year. We also present the Copenhagen Memory Clinic Cohort and the associated biobank, as well as clinical, translational and epidemiological research programs performed at DDRC during the past 30 years. Funded in part by the Danish Ministry of Health, our national outreach, professional networks and educational programs are also outlined. From its inception and onwards the primary focus of the DDRC has been with the patients, aiming to continuously improve our clinical service based on research and innovation and to improve the quality of care nationwide. We welcome requests for collaboration on research, innovation and education from international colleagues and research centers.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"883-898"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposures and conditions prior to age 16 are associated with incidence of dementia status among adults in the United States Health and Retirement Study. 在美国健康和退休研究中，16岁之前的暴露和条件与成人痴呆状态的发病率有关。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-14 DOI: 10.1177/13872877251365283

Scarlet Cockell, Herong Wang, Kelly S Benke, Erin B Ware, Kelly M Bakulski

{"title":"Exposures and conditions prior to age 16 are associated with incidence of dementia status among adults in the United States Health and Retirement Study.","authors":"Scarlet Cockell, Herong Wang, Kelly S Benke, Erin B Ware, Kelly M Bakulski","doi":"10.1177/13872877251365283","DOIUrl":"10.1177/13872877251365283","url":null,"abstract":"BackgroundDementia and cognitive impairment are prevalent conditions, and susceptibility likely begins years before symptoms. Early life has not been comprehensively tested for potential risk factors for dementia.ObjectiveTo explore the associations between childhood conditions and exposures and cognitive impairment in adulthood.MethodsIn the US Health and Retirement Study (normal baseline cognition; n = 16,509; 2008-2018 waves), 31 exposures before age 16 were retrospectively assessed with ten-year incident cognitive status (dementia, impaired, normal). Using parallel modified Poisson models, each exposure was tested with incident cognition, adjusting for sex, baseline age, follow-up, race/ethnicity, personal/parental education.ResultsAmong the analytic sample, participants were mean 61 years of age at baseline and all had normal cognition. During up to 10 years of follow-up, 14.5% developed cognitive impairment and 5.3% developed dementia. Participants with depression during childhood had 1.49 (95%CI:1.2,1.84) times higher risk of incident impairment, relative to normal cognition. Participants with headaches/migraines during childhood had 1.43 (95%CI:1.14,1.79) times higher risk of incidence of dementia. Participants with learning problems during childhood had 1.71 (95%CI:1.44,2.03) times higher risk of incident impairment. Childhood self-rated health of fair (1.59, 95%CI:1.2,2.1) and poor (2.42, 95%CI:1.62,3.61) had higher risk of incidence of dementia, relative to excellent self-rated health. Associations between additional exposures and either incident impairment or dementia did not reach the multiple testing threshold (false discovery rate < 0.01).ConclusionsConditions and exposures during the early life period may be important for later life cognitive impairment or dementia. These findings support extending the relevant dementia risk window to evaluate childhood.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1168-1186"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144846578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of drugs targeting the renin-angiotensin system and global cognition in aging. 针对肾素-血管紧张素系统与衰老整体认知的药物比较。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1177/13872877251365541

Claudene J George, Kay Thwe Kyaw, Charles B Hall, Erica F Weiss, Joe Verghese, Peter Abadir

{"title":"A comparison of drugs targeting the renin-angiotensin system and global cognition in aging.","authors":"Claudene J George, Kay Thwe Kyaw, Charles B Hall, Erica F Weiss, Joe Verghese, Peter Abadir","doi":"10.1177/13872877251365541","DOIUrl":"10.1177/13872877251365541","url":null,"abstract":"BackgroundHypertension (HTN) is a major risk factor for Alzheimer's disease (AD) and related dementias. Renin-angiotensin system (RAS) medications, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), have been proposed to mitigate cognitive decline, but evidence remains inconsistent.ObjectiveCompare global cognition over time among ARB, ACEI, and non-RAS drug users.MethodsData from the Rush Memory and Aging Project (1997-2006) included 2019 participants. Global cognition was assessed using a composite z-score of 19 cognitive tests. Participants were categorized by medication use: ARB, ACEI, or non-RAS. Analysis of covariance (ANCOVA) was performed to compare cognitive outcomes over 9 years, adjusting for baseline cognition, social determinants, and medical factors. Subgroup analyses evaluated cognitive domains and the impact of HTN.ResultsAt baseline, ARB and ACEI users had more vascular risk factors and medical conditions than non-RAS users. At 9 years, ARB users had slightly better global cognitive outcomes compared to ACEI (LS-mean difference: 0.015, 95% CI [-0.175, 0.205]) and non-RAS users (LS-mean difference: 0.06, 95% CI [-0.11, 0.23]), though differences were not statistically significant. ACEI users showed significant improvement in working memory compared to non-RAS users (LS-mean: 0.157, 95% CI [0.002, 0.313]). Among participants without HTN, ACEI use was associated with significantly reduced cognitive decline compared to non-RAS use.ConclusionsARBs may benefit global cognitive function, while ACEIs may yield improvements in specific domains like working memory. Further studies are needed to confirm these findings and explore the impact of drug characteristics such as blood-brain-barrier penetration.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1200-1208"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and comparison of alternate forms of the Loewenstein-Acevedo Scales for Semantic Interference and Learning-Digital Version (LASSI-D) in older participants with amnestic mild cognitive impairment and normal cognition. Loewenstein-Acevedo语义干扰量表和学习数字版量表（lasi - d）在老年遗忘轻度认知障碍和正常认知障碍受试者中的开发与比较

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-29 DOI: 10.1177/13872877251379363

Breanna Huang-Ouyang, Rosie E Curiel Cid, Sara J Czaja, Peter Kallestrup, Andrea Rivera Molina, Annalee Mueller, Elizabeth A Crocco, David A Loewenstein, Philip D Harvey

{"title":"Development and comparison of alternate forms of the Loewenstein-Acevedo Scales for Semantic Interference and Learning-Digital Version (LASSI-D) in older participants with amnestic mild cognitive impairment and normal cognition.","authors":"Breanna Huang-Ouyang, Rosie E Curiel Cid, Sara J Czaja, Peter Kallestrup, Andrea Rivera Molina, Annalee Mueller, Elizabeth A Crocco, David A Loewenstein, Philip D Harvey","doi":"10.1177/13872877251379363","DOIUrl":"https://doi.org/10.1177/13872877251379363","url":null,"abstract":"BackgroundEarly detection of amnestic mild cognitive impairment (aMCI) is crucial for early intervention. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) identify risk for cognitive decline by measuring proactive semantic interference (PSI). PSI correlates with critical Alzheimer's disease (AD) biomarkers, predicting decline. A digital version of the LASSI™, the LASSI-D™, was highly convergent with the LASSI-L in older participants.ObjectiveWe developed three alternative forms of the LASSI-D™, examining convergence across forms and retest changes, to evaluate utility as a repeated-measure.MethodsAlternative forms were developed in English and Spanish. 77 participants meeting criteria for aMCI and 92 participants with normal cognition were tested twice at a 2-week interval. Participants who were assessed first with the LASSI-D were retested with the LASSI-L and vice versa. Critical variables for the LASSI™ are indices of PSI, including reduced learning of the second word list and recall intrusions when attempting to recall the second list.ResultsThere were no form or group differences on any PSI-related variable across alternative forms, all ps > 0.6, with the digital forms and LASSI-L equivalently sensitive to aMCI, (all ps < 0.01). Intrusion errors were essentially identical for LASSI forms across, (all p > 0.86), without significant practice effects. Performance did not differ across language for any variable across groups, forms, and assessments, all ps > 0.010.ConclusionsThree digital alternative forms of the LASSI™ were highly convergent with each other and the LASSI-L. The findings provide evidence of the utility of a cloud-based, self-administered cognitive challenge test with alternative forms.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251379363"},"PeriodicalIF":3.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of middle-latency somatosensory evoked magnetic field waveforms associated with the pathophysiological states of Alzheimer's disease. 与阿尔茨海默病病理生理状态相关的中潜伏期体感诱发磁场波形的调节。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-26 DOI: 10.1177/13872877251379466

Emi Tanaka, Takashi Nihashi, Takashi Kato, Yutaka Arahata, Akinori Takeda, Keita Sakurai, Katsunori Yokoi, Kaori Iwata, Kersten Diers, Burkhard Maess, Akinori Nakamura

{"title":"Modulation of middle-latency somatosensory evoked magnetic field waveforms associated with the pathophysiological states of Alzheimer's disease.","authors":"Emi Tanaka, Takashi Nihashi, Takashi Kato, Yutaka Arahata, Akinori Takeda, Keita Sakurai, Katsunori Yokoi, Kaori Iwata, Kersten Diers, Burkhard Maess, Akinori Nakamura","doi":"10.1177/13872877251379466","DOIUrl":"https://doi.org/10.1177/13872877251379466","url":null,"abstract":"BackgroundAlzheimer's disease (AD) frequently causes epilepsy and myoclonus. These symptoms are thought to be associated with neuronal hyperexcitability, highlighting the need for biomarkers that reflect synaptic functional alterations.ObjectiveWe aimed to examine changes in neuronal excitability associated with AD progression using magnetoencephalography (MEG). Furthermore, we investigated the relationship between alterations in electromagnetic signals and other neuroimaging biomarkers.MethodsWe measured middle-latency somatosensory evoked magnetic fields (m-SEFs) following right median nerve stimulation in 45 individuals, comprising 6, 8, and 31 individuals with AD dementia (ADD), mild cognitive impairment (MCI), and cognitively healthy older adults, respectively. Cortical reactivity relative to the primary somatosensory response (N20 m) was assessed using normalized m-SEF waveforms. Additionally, we analyzed associations between these waveforms and amyloid-β (Aβ) deposition, regional glucose metabolism, and gray matter volume using positron-emission tomography and magnetic resonance imaging.ResultsThe m-SEF waveform exhibited six components (M2-M7) within 150 ms of the N20 m (M1) response. The m-SEF waveforms tended to be enlarged in ADD and MCI, with a significant enhancement of M2 in ADD. The amplitude of M7 at approximately 100 ms latency was significantly and positively correlated with local Aβ deposition in the sensorimotor cortex. Moreover, regional glucose hypometabolism in the hippocampus and pulvinar was significantly associated with enlargement of the M4, M6, and M7 components.ConclusionsThese findings indicate that cortical responses to somatosensory stimulation are modulated by AD progression. M-SEF may serve as a potential marker for evaluating cortical excitability in the sensorimotor cortex.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251379466"},"PeriodicalIF":3.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0