Journal of Alzheimer's Disease最新文献

{"title":"Virtual reality-based interventions for individuals with dementia: A potential further treatment and new perspectives.","authors":"Renato Sobral Monteiro-Junior","doi":"10.1177/13872877251328723","DOIUrl":"https://doi.org/10.1177/13872877251328723","url":null,"abstract":"<p><p>This commentary highlights issues regarding virtual reality (VR)-based interventions for individuals with Alzheimer's disease, emphasizing their potential to improve cognitive function and delay decline. The aim of this manuscript is to present current findings and critically synthesize the practical applications of VR interventions. A recent meta-analysis demonstrates promising results, with VR interventions enhancing memory, executive functions, and overall cognition. Despite the limited number of studies and small sample sizes, findings suggest that engaging VR environments can motivate patients, fostering adherence to treatment. This commentary underscores the need for further research to validate these results and establish standardized methodologies for the effective use of VR in dementia care. Several methodological aspects and new perspectives are highlighted herein.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251328723"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validate association of gene loci and establish genetic risk prediction models for late-onset Alzheimer's disease in Chinese populations.","authors":"Fangyu Li, Menghan Zheng, Jianping Jia","doi":"10.1177/13872877251326283","DOIUrl":"https://doi.org/10.1177/13872877251326283","url":null,"abstract":"<p><p>BackgroundMore than 60 independent single-nucleotide polymorphisms (SNPs) have been associated with Alzheimer's disease risk by genome-wide association studies in European.ObjectiveWe aimed to confirm these SNPs in Chinese Han populations and investigate the utility of these genetic markers.MethodsAltogether 1595 late-onset Alzheimer's disease (LOAD) patients and 2474 controls from Chinese population were recruited. We replicated the association of 68 SNPs with LOAD and established polygenetic risk score (PRS) prediction model using significant SNPs. Meta-analysis for <i>MS4A6A</i> rs610932 and <i>PICALM</i> rs3851179 were performed.ResultsAccording to our findings, 14 out of 68 SNPs are validated significantly associated with LOAD (adjusted p < 0.05) after adjusting age and sex in the Chinese population. Besides, after stratification by <i>APOE</i> ε4 status, almost all SNPs retain markedly relationship with LOAD in <i>APOE</i> ε4 noncarriers. However, few loci retain correlation in <i>APOE</i> ε4 carriers. Furthermore, the area under the receiver operating characteristic curve prediction model for distinguishing LOAD patients from normal subjects were 0.614 for PRS and 0.689 for PRS and <i>APOE</i>. In addition, meta-analysis including this study of East Asian populations confirmed that rs610932 and rs3851179 were dramatically related to the LOAD (OR = 0.85, 95% CI = 0.74-0.97; OR = 0.87, 95% CI = 0.83-0.91).ConclusionsDespite genetic heterogeneity, there are still common loci among different races. PRS based on AD risk-associated SNPs may supplement <i>APOE</i> for better assessing individual risk for AD in Chinese. Besides, interactions between genes and gene environment affect the impact of risk allele on diverse populations.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251326283"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a developed cognitive training system based on virtual reality with smart mirror for expert in community older cognitive disabled persons setting.","authors":"Bo-Ra Kang, Young-Hyeon Bae, Seong Hun Park, Hye-Yun Kang","doi":"10.1177/13872877251330147","DOIUrl":"https://doi.org/10.1177/13872877251330147","url":null,"abstract":"<p><p>BackgroundNumerous stroke survivors reintegrating into the community experience cognitive challenges that restrict their engagement, subsequently contributing to additional cognitive decline and adversely affecting their quality of life.ObjectiveThis study seeks to feasibility a cognitive training system based on virtual reality with a smart mirror designed for cognitive disabled persons with chronic stroke in the community setting.MethodsTen cognitive disabled persons with chronic stroke aged 60 years older, each with independent mobility in the community, were involved in this study. The validation process included a 30-min cognitive training session administered twice a week for eight weeks. The feasibility of cognitive function assessments employed the MoCA-K and CoSAS. Additionally, a usability test was performed at the end of the experiment using SUS and the Adapted IMI. The Wilcoxon signed rank test was then employed to compare pre- and post-cognitive function results.ResultsThe feasibility of the implemented cognitive training system based on virtual reality with smart mirror revealed significant differences in the total score, delayed recall, and orientation items of the MoCA-K (p < 0.05). Additionally, a notable improvement was observed in the accuracy and response time of task performance in the CoSAS (p < 0.05). Usability test results indicated an SUS mean score of 73.5 (SD 17.25) and an Adapted IMI score of 5.63 (SD 1.55), surpassing suggested thresholds for usability tests.ConclusionsProviding a cognitive training system tailored for the community, this approach aims to the prevention and recovery of cognitive issues in the older cognitive disabled persons with chronic stroke.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251330147"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social functioning in individuals with Alzheimer's disease and the situation of caregivers.","authors":"Sophia Kraake, Melanie Luppa, Dorothee Saur, Jens Dietzel, Jan-Philipp Bach, Steffi G Riedel-Heller, Janine Stein","doi":"10.1177/13872877251326029","DOIUrl":"https://doi.org/10.1177/13872877251326029","url":null,"abstract":"<p><p>BackgroundChanges in social functioning may be a significant parameter for the early detection of Alzheimer's disease (AD). Currently, research on social functioning in AD across the entire spectrum of the disease is lacking.ObjectiveThe aim of this study was to describe the social functioning of persons with AD at each stage of the disease and to investigate how impaired social functioning affects caregiver burden.MethodsCross-sectional data was derived from memory clinics across Germany as part of the pilot study \"Social functioning in individuals with AD and the situation of caregivers\". A total of N = 87 relatives providing care for individuals with mild (n = 20), moderate (n = 40), and severe (n = 23) AD were included. Social functioning of individuals with AD was measured via the caregiver-rated German version of the Social Functioning in Dementia Scale (SF-DEM); caregiver burden was assessed using the Zarit Caregiver Burden Interview (ZBI-12). Differences between mild, moderate, and severe AD in terms of sociodemographic characteristics and the level of social functioning were examined. A robust linear regression analysis was conducted to examine the association between social functioning and caregiver burden.ResultsSocial functioning was lower in moderate and severe AD than in mild AD. Higher levels of social functioning were associated with less caregiver burden.ConclusionsThis study highlights the importance of integrating social functioning assessments into clinical practice for improving the early detection, diagnosis and interventions for AD. Early interventions to enhance social functioning may diminish caregiver burden.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251326029"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of anti-seizure medications on Alzheimer's disease (AD) risk and AD-related symptoms: A scoping review.","authors":"Jonathan P Williams, Yiqi Zhu, Ramkrishna K Singh, Kebede Beyene, Rohan Rani, Xian Kapetanakos, Amanda Dias, Katherine McGuire, Ramana Kolady, Kim Lipsey, Sridharan Gopalsamy Ramaswamy, Vishnuvardhan Thotakura, Jean-Francois Trani, Ganesh M Babulal","doi":"10.1177/13872877251324663","DOIUrl":"https://doi.org/10.1177/13872877251324663","url":null,"abstract":"<p><p>BackgroundAs the fastest-growing segment of the population, adults over 65 are at the most significant risk for Alzheimer's disease (AD). Older adults often use anti-seizure medications (ASMs), which can negatively impact cognitive function, mood, and behavior, mimicking AD or its symptoms. Understanding the effects of ASMs across diverse older adults is crucial, given that some ethnoracial groups are at higher risk for AD or more severe symptoms compared to non-Hispanic Whites.ObjectiveTo summarize the current evidence on the association of ASMs with AD risk and AD-related symptoms and explore the inclusion of ethnoracial minority groups in these studies.MethodsData sources included PubMed/MEDLINE, EMBASE, and SCOPUS for English-language studies published between 1990-2024. Selected studies were peer-reviewed, cross-sectional, longitudinal, case-control, and clinical trials on AD dementia or related symptoms and ASMs. Study quality was rated by the Oxford Centre for Evidence-Based Research Medicine.ResultsA total of 27 studies with 1,241,796 participants were included. Data on AD risk from level IB-IIIB evidence studies showed mixed results, with some indicating an increased association with ASM use [OR = 1.05-1.16, 95% CI: 1.01-1.24]. Studies on AD-related symptoms from level IB-IV evidence also showed mixed results. Only three North American studies explicitly included race/ethnicity; most were conducted in European countries.ConclusionsASM use may be modestly associated with an increased risk of AD among the older adult population, but current data are inconclusive. The association of ASMs on AD-related symptoms varied. Future studies should emphasize reporting sociodemographic data and include diverse cohorts to enhance the applicability of findings.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251324663"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local and distant atrophy mediate the relationship between tau pathology and cognition in temporoparietal region in Alzheimer's disease.","authors":"Xinru Xu, Xian Mo, Wen Zhang, Dongming Liu, Qian Chen, Jiaming Lu, Yajing Zhu, Jiu Chen, Xin Zhang, Zhengyang Zhu, Yingxin Chen, Qingxue Shi, Yingxin Dai, Miao Liu, Yanan Tong, Jinghua Zhang, Guoxu Zhang, Zhiguo Wang, Bing Zhang","doi":"10.1177/13872877251322539","DOIUrl":"https://doi.org/10.1177/13872877251322539","url":null,"abstract":"<p><p>BackgroundTau pathology is closely associated with brain atrophy and cognitive decline, but how it specifically influences local and distant gray matter volume (GMV) and cognitive function remains unclear.ObjectiveThis study aims to explore the spatial relationships between tau pathology, GMV and cognition using hybrid positron emission tomography/magnetic resonance imaging (PET/MRI).MethodsTwenty amyloid-β (Aβ)-positive Alzheimer's disease (AD) patients, 14 mild cognitive impairment (MCI) patients, and 22 Aβ-negative normal controls (NC) underwent standardized neuropsychological assessments and ¹⁸F-fortaucipir PET/MRI scans. We investigated the associations between regional tau standardized uptake value ratio (SUVR) and GMV in AD signature regions. Mediation analyses were conducted to explore the potential mediating effects of local and distant GMV in the relationship between tau pathology and cognition.ResultsThe study indicated that increased ¹⁸F-fortaucipir SUVR and decreased GMV were related to cognitive performance in MCI and AD patients. Compared to NC group, the number of brain regions with local and distant correlations between GMV and SUVR was greater in AD/MCI group. Mediation analysis revealed that GMV served as a significant mediator between tau pathology and cognition in local regions. Furthermore, distant effects were also observed, with hippocampal atrophy partially mediated the relationship between entorhinal cortex tau pathology and cognition. Meanwhile, medial parietal lobe atrophy partially mediated the relationship between medial temporal lobe tau deposition and cognition.ConclusionsOur findings provide an anatomically detailed insight into relationships between tau, GMV and cognition, especially in entorhinal cortex-hippocampus, temporal-parietal lobe cortical circuits.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251322539"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced GABA_{A, slow} synaptic inhibition in Alzheimer's disease.","authors":"M Bruce MacIver, Robert A Pearce","doi":"10.1177/13872877251328940","DOIUrl":"https://doi.org/10.1177/13872877251328940","url":null,"abstract":"<p><p>Altered synaptic physiology clearly contributes to memory loss and other CNS symptoms in Alzheimer's disease. A new paper in this issue of the <i>Journal of Alzheimer's Disease,</i> from Zhe Jin's group in Uppsala, Sweden, adds important new information to help us understand how. A powerful, yet largely uncharacterized form of neuronal inhibition-GABA_{A, slow} synaptic current-was studied using whole-cell recordings in hippocampal brain slices from AD model mice (tg-APPSwe). The investigators found that GABA_{A, slow} inhibition was significantly reduced in dentate granule neurons from aged AD mice, compared to both wild type and adult non-aged AD mice. This reduction would nicely explain the change in excitatory-inhibitory balance previously reported in this and other AD model animals, as well as impairments in pattern separation and theta-gamma cross-frequency coupling that are early manifestations of AD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251328940"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring interdisciplinary perspectives on the implementation of <i>personalized medicine</i> and <i>patient-orchestrated care</i> in Alzheimer's disease: A qualitative study within the ABOARD research project.","authors":"Tanja J de Rijke, Dianne Vasseur, Wiesje M van der Flier, Mirella Mn Minkman, Hanneke Fm Rhodius-Meester, Nicolaas A Verwey, Ellen Ma Smets, Leonie Nc Visser","doi":"10.1177/13872877251326166","DOIUrl":"https://doi.org/10.1177/13872877251326166","url":null,"abstract":"<p><p>BackgroundThe concepts of '<i>personalized medicine</i>' and '<i>patient-orchestrated care</i>' in Alzheimer's disease (AD) lack standard conceptualization, which presents challenges for collaborative and interdisciplinary care.ObjectiveWe explored the interpretations and perspectives of professionals involved in interdisciplinary work on a large-scale project, \"ABOARD\", with the aim to implement <i>personalized medicine</i> and <i>patient-orchestrated care</i> in AD.MethodsSemi-structured interviews were conducted with 30 professionals and audio-recorded. Two researchers independently coded the data inductively, followed by a thematic analysis.ResultsAccording to professionals across different disciplinary backgrounds (mean age 45.7 years; 53.3% female), <i>personalized medicine</i> pertains to the relevant options that an individual has, informed by biomedical and psychosocial factors, whereas <i>patient-orchestrated care</i> captures factors relevant to the decision-making process. Professionals differed in their views on <i>patient-orchestrated care</i> regarding its desirability and feasibility. The concepts were viewed as similar by professionals, as both involve personal preferences while ultimately assigning responsibility to the clinician. However, implementation challenges persist, and no thematic differences were found between clinicians and other AD-related professionals.ConclusionsAD professionals have shared interpretations and perspectives on implementation of <i>personalized medicine</i> but differed in their views on patient-orchestrated care. Personal preferences are seen as part of <i>personalized medicine</i>, but not yet reflected in definitions in the AD field and beyond. Critical discussions on the challenges and existing doubts are necessary for both <i>personalized medicine</i> and <i>patient-orchestrated care</i>. Multi-level implementation changes are needed for both concepts, which warrants stakeholder involvement as well as support and resources from the entire AD field.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251326166"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A statistical method for predicting amyloid-β deposits from severity, extend, and ratio indices of the ^99mTc-ECD SPECT.","authors":"Takashi Asada, Tatsuyuki Kakuma, Mieko Tanaka, Wataru Araki, Adam Jon Lebowitz, Toshimitsu Momose, Hiroshi Matsuda","doi":"10.1177/13872877251324222","DOIUrl":"https://doi.org/10.1177/13872877251324222","url":null,"abstract":"<p><p>BackgroundAmyloid-β (Aβ) deposit prediction accuracy is necessary for clinicians treating patients desiring Alzheimer's disease (AD) modifying drugs. Aβ-PET imaging is useful for diagnosis, but high in cost compared to brain perfusion SPECT. However, SPECT displays regional cerebral blood flow (rCBF) and does not detect Aβ deposits, therefore requiring additional clinical information.ObjectiveThis article describes a novel statistical method to predict amyloid deposits via PET images (Aβ+ or Aβ-) using the three indices of the ^99mTc-ECD SPECT - severity, extend, and ratio - for the three ROIs.MethodsCandidate patients (N = 114 patients [55% male], 81 Aβ+ 33 Aβ-, mean age 74.2 ± 6.6 years, mean MMSE score 23.7 ± 2.8) underwent MRI and ^99mTc-ECD SPECT scanning. After examining SPECT index, demographic, and age data, age and sex were treated as confounders in one, two, and three-index logistic additive models with severity, extend, and ratio as explanatory variables. Area under curve (AUC), sensitivity and specificity were used as statistical indices for model fitness and accuracies. Three-hold cross validation analyses were conducted to evaluate error rates.ResultsAccording to ROC analysis, best scores for fitness and accuracy were obtained from the three-index model with patients' age and sex for the configured ROIs including precuneus, posterior cingulate and temporal-parietal region of SPECT (AUC: 0.818, Sensitivity: 0.803, Specificity: 0.727).ConclusionsThis technique using ^99mTc-ECD SPECT data can predict amyloid deposits with acceptable accuracy. To confirm the reliability and validity, a multicenter SPECT study is needed.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251324222"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary study on plasma markers across cognitive stages and links to a history of mild traumatic brain injury.","authors":"Christian LoBue, Barbara E Stopschinski, Nil Saez Calveras, Amber Salter, Doug Galasko, Chris Giza, C Munro Cullum, Peter M Douglas, John Hart","doi":"10.1177/13872877251325757","DOIUrl":"10.1177/13872877251325757","url":null,"abstract":"<p><p>Potential implications of a history of mild traumatic brain injury (mTBI) during aging are understudied. Seven plasma markers were measured in matched participants having normal cognition, mild cognitive impairment (MCI) and dementia of the Alzheimer's type (DAT) with and without a history of mTBI. Phosphorylated tau₁₈₁ showed a moderate effect size for being greater in mTBI + individuals having MCI and DAT, and effect sizes for lower amyloid-β 42/40 and higher neurofilament light were seen for mTBI + DAT individuals. This preliminary report shows a potential role of plasma-derived markers in detecting associations between mTBI history and the development of Alzheimer's disease and related disorders.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251325757"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}