Journal of Alzheimer's Disease最新文献

{"title":"Interactive effects of <i>APOE</i> ɛ4 status and vascular burden on white matter microstructural integrity in aging with and without neurocognitive decline.","authors":"Srijan Konwar, Riccardo Manca, Matteo De Marco, Hilkka Soininen, Annalena Venneri","doi":"10.1177/13872877251320660","DOIUrl":"https://doi.org/10.1177/13872877251320660","url":null,"abstract":"<p><p>BackgroundCarrying the Apolipoprotein (<i>APOE</i>) ε4 allele lowers age of onset and increases Alzheimer's disease (AD) risk. Neuropathological findings suggest a mixed etiology in many AD patients, and vascular pathology is common.ObjectiveThis study tested the interactive effect of <i>APOE</i> status and multiple vascular comorbidities on white matter (WM) microstructure in aging and early AD.Methods195 participants from the VPH-DARE@IT dataset were stratified in low/high vascular burden based on the Framingham Risk Score (BMI version). Tract-based spatial statistics was used for WM analyses.ResultsThere was a main effect of <i>APOE</i>, with <i>APOE</i> ɛ4 carriers having higher fractional anisotropy (FA) and lower axial diffusivity (AxD), mean diffusivity (MD), and radial diffusivity (RD) than non-carriers. There was a main effect of vascular burden with lower FA and higher AxD, MD, and RD in the high-burden than the low-burden group. A significant interaction between <i>APOE</i> genotype and vascular burden was also found for all diffusion indices. <i>Post-hoc</i> comparisons revealed lower left hemisphere WM integrity when comparing the low risk group (i.e., non-carriers low burden) to intermediate risk groups (i.e., non-carriers high burden or ɛ4 carriers low burden). The contrasts between the two intermediate risk groups showed altered WM integrity bilaterally. Only the non-carriers high burden showed greater alterations in WM integrity when compared with the high risk group (i.e., ɛ4 carriers high burden) mainly in right hemisphere tracts.ConclusionsThese findings indicate an interactive effect of a risk gene and vascular comorbidities on WM integrity in aging and early AD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251320660"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life-long music and dance relationships and therapeutic impressions in individuals with and without mild cognitive impairment to inform the design of music- and dance-based therapies.","authors":"Meghan E Kazanski, Sahrudh Dharanendra, Michael C Rosenberg, Danyang Chen, Emma Rose Brown, Laura Emmery, J Lucas McKay, Trisha M Kesar, Madeleine E Hackney","doi":"10.1177/13872877241294090","DOIUrl":"10.1177/13872877241294090","url":null,"abstract":"<p><p>BackgroundNo effective therapies exist to prevent neurodegenerative mild cognitive impairment (MCI) related to Alzheimer's disease. Therapies integrating music and/or dance are promising non-pharmacological options to effectively mitigate cognitive decline.ObjectiveTo deepen our understanding of individuals' relationships (i.e., histories, experiences, and attitudes) with music and dance, in order to incorporate such knowledge into the design of music- and dance-based interventions, thereby improving therapeutic outcomes.MethodsEleven older adults with MCI and five of their care partners/ spouses (4 M/12F; Black: n = 4, White: n = 10, Hispanic/Latino: n = 2; Age: 71.4 ± 9.6 years) first completed questionnaires, then participated in focus groups that captured aspects of their relationships with music and dance. Emergent themes were extracted from four major topics, including: (1) experience and history, (2) enjoyment and preferences, (3) confidence and barriers, and (4) impressions of music and dance as therapeutic tools.ResultsThematic analysis revealed participants' positive impressions of music and dance as potential therapeutic interventions, citing perceived neuropsychological, emotional, and physical benefits. Participants viewed music and dance as integral to their lives, histories, and identities within a culture, family, and/ or community. Participants also identified lifelong engagement barriers that, in conjunction with negative feedback, instilled persistent low self-efficacy regarding dancing and active music engagement. Questionnaires verified individuals' moderately-strong music and dance relationships, which were strongest in passive forms of music engagement (e.g., listening).ConclusionsOur findings support that individuals' music and dance relationships and the associated perceptions toward music and dance therapy may offer valuable insights that enhance the design of efficacious and engaging non-pharmacological therapies for individuals with MCI.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877241294090"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validating a brief performance-based measure of cognition and daily functioning in amnestic mild cognitive impairment and mild Alzheimer's disease.","authors":"Sydney Y Schaefer, Alexandra M Reed, Kevin Duff","doi":"10.1177/13872877251320379","DOIUrl":"https://doi.org/10.1177/13872877251320379","url":null,"abstract":"<p><p>BackgroundThe Clinical Dementia Rating (CDR) scale is widely used as a cognitive and functional measure in Alzheimer's disease (AD) clinical trials. Given its time and personnel burden, there is a need to more efficiently identify patients who warrant further evaluation or clinical trial qualification. To potentially address this need, a novel performance-based test of cognition and daily functioning has been developed for use in AD research and clinical care.ObjectiveTo test whether this novel performance-based test is associated with levels of daily functioning in both impaired and unimpaired individuals.MethodsOne-hundred-seventy-one participants (72 cognitively unimpaired; 53 amnestic mild cognitive impairment; 46 mild AD) completed the novel performance-based test of cognition and daily functioning, as well as the Quick Dementia Rating System (QDRS) for estimating global CDR.ResultsThe novel test was significantly associated with the QDRS Total, as well as the Behavioral and Cognitive subdomains, and differentiated between estimated global CDR scores of 0 versus ≥0.5. No significant effect of age, sex, or education on the performance-based test was observed.ConclusionsThe performance-based test used in this study can be considered a measure of cognition and daily functioning. As such, it may be a quick, objective method for identifying impaired individuals who may qualify for clinical trial enrollment or may warrant further evaluation without the need for informant input.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251320379"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 diabetes and late-onset Alzheimer's disease and related dementia: A longitudinal cohort study integrating polygenic risk score.","authors":"Sohyun Jeong, Lisha Lin, Alvaro-Pascual Leone, Yi-Hsiang Hsu","doi":"10.1177/13872877251326107","DOIUrl":"https://doi.org/10.1177/13872877251326107","url":null,"abstract":"<p><p>BackgroundThe inherent genetic effects were not established between type 2 diabetes (T2DM) and Alzheimer's disease and related dementia (ADRD).ObjectiveWe aimed to investigate the association between T2DM and ADRD by integrating T2DM polygenic risk score (PRS) and applying matching in every subgroup.MethodsWe utilized UK Biobank First-occurrences datasets. T2DM were 1:1 matched to non-T2DM using propensity scores generated by 8 covariates; age at diagnosis, sex, cerebrovascular disease, ischemic heart disease, hypertensive disorders, lipid disorders, obesity, and mood disorders. T2DM PRS was additionally matched in T2DM PRS matched analysis. Subgroup analyses by age at diagnosis, sex, and <i>APOE4</i> genotype were performed with the same matching criteria within each subgroup. Cox proportional hazard and Fine & Gray competing risk model were utilized.ResultsIn T2DM PRS unmatched cohort, 24,583 T2DM were 1:1 matched to non-T2DM. The mean age at diagnosis was around 62 years old, with females constituting around 40%. Up to 25-year follow-up, ADRD rate/1000 person-years was 0.88 versus 1.52 (Non-T2DM versus T2DM); PRS unmatched (cHR: 1.72, 95% CI: 1.46-2.03) and matched (cHR:1.75, 95% CI: 1.47-2.09). Except for older age onset (≥75 years), the other subgroups demonstrated significantly increased ADRD risks in T2DM. T2DM PRS was higher in non-ADRD group across all subgroups. Contrarily, T2DM PRS was higher in ADRD in younger onset group (<55 years).ConclusionsT2DM is one of the strong risk factors of ADRD but genetic T2DM effect does not contribute to ADRD risk. However, a genetic link might be present in younger age onset group.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251326107"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition and vascular factors: Insights from carotid intima-media thickness and ankle-brachial index in a cohort.","authors":"Kai-Jing Yeh, Meng-Jie Sun, Shin-Joe Yeh, Sung-Chun Tang, Jeng-Min Chiou, Yen-Ching Chen, Jen-Hau Chen","doi":"10.1177/13872877251319557","DOIUrl":"https://doi.org/10.1177/13872877251319557","url":null,"abstract":"<p><p>BackgroundLimited research has explored the intercorrelation between peripheral and central vascular factors on cognition incorporated longitudinal cognitive measures.ObjectiveExplore associations between central and peripheral vascular factors and cognition.MethodsThis prospective cohort study recruited 516 older adults at baseline (2011-2013) with three follow-ups until 2019. Global and domain-specific cognition (memory, executive function, verbal fluency) were assessed biennially. The ankle-brachial index (ABI) and carotid intima-media thickness (CIMT) were the peripheral and central vascular markers. Generalized linear mixed models were utilized to explore the relationship between vascular factors and cognition adjusting for relevant covariates.ResultsOver time, one unit increment in the ABI was associated with decreased attention performance (<math><mrow><mover><mi>β</mi><mo>^</mo></mover></mrow></math> = -1.26). At baseline, one unit increase in CIMT (1 mm) was associated with better attention performance (<math><mrow><mover><mi>β</mi><mo>^</mo></mover></mrow></math> = 0.93) while the association decreased over time (<math><mrow><mover><mi>β</mi><mo>^</mo></mover></mrow></math> = -0.23). Over time, a unit increase in CIMT was associated with poor performance in global cognition (<math><mrow><mover><mi>β</mi><mo>^</mo></mover></mrow></math> = -0.52), memory (<math><mrow><mover><mi>β</mi><mo>^</mo></mover></mrow></math> = -0.21), executive function (<math><mrow><mover><mi>β</mi><mo>^</mo></mover></mrow></math> = -0.16), and verbal fluency (<math><mrow><mover><mi>β</mi><mo>^</mo></mover></mrow></math> = -0.15). These associations were particularly evident in <i>APOE</i> ε4 non-carriers, participants without lacunar infarct, and participants with hyperintensities. A significant interaction was found between lacunar infarct and CIMT on attention performance over time. Participants with both abnormal ABI (either low or high) and elevated CIMT showed the most pronounced decline in attention and memory domains, suggesting that the joint effect of these vascular markers affects cognitive performance.ConclusionsPeripheral and central vascular factors differentially and jointly affect cognitive performance, emphasizing the importance of promoting vascular health to prevent dementia in the preclinical phase.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251319557"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving executive functioning and reducing the risk of Alzheimer's disease with music therapy: A narrative review of potential neural mechanisms.","authors":"Benjamin Slade, Ben Williams, Romy Engelbrecht, Joseph Ciorciari","doi":"10.1177/13872877251327762","DOIUrl":"https://doi.org/10.1177/13872877251327762","url":null,"abstract":"<p><p>The incidence of Alzheimer's disease (AD) and the concurrent cost of healthcare will increase as the population continues to age. Pharmaceutical interventions effectively manage symptoms of AD but carry side effects and ineffectively address underlying causes and disease prevention. Non-pharmaceutical interventions for AD, such as music training and therapy do not carry these side effects and can improve symptoms, and should therefore be explored as stand-alone or co-therapy for AD. In addition, music encapsulates modifiable lifestyle factors, such as cognitive stimulation, that have been shown to delay progression of and prevent AD. However, the neural mechanisms underpinning how music improves AD symptoms are not fully understood and whether music can target compensatory processes, activate neural networks, or even slow or prevent AD needs further research. Research suggests neural mechanism may involve stimulating brain areas to promote neurogenesis, dopaminergic rewards systems, and the default mode network (DMN). Alternatively, this review proposes that music improve symptoms of AD via the fronto-parietal control network (FPCN), the salience network (SN) and DMN, and neural compensation. This review will then present evidence for how music could activate the FPCN, SN, and DMN to improve their efficiency, organization, and cognitive functions they govern, protecting the brain from damage, slowing progression, and possibly preventing AD. Establishing how music improves symptoms of AD can lead to tailored music therapy protocols that target functional neural networks responsible for impaired executive functions common in AD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251327762"},"PeriodicalIF":3.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of 2 and 4 weeks repetitive transcranial magnetic stimulation inducing neuroplasticity on cognitive improvement.","authors":"Xian Shi, Wen-Ao Zheng, Xin-Le Hou, Ya Chen, Hai-Feng Chen, Wei-Na Yao, Ting-Yu Lv, Feng Bai","doi":"10.1177/13872877251320124","DOIUrl":"https://doi.org/10.1177/13872877251320124","url":null,"abstract":"<p><p>BackgroundRepetitive transcranial magnetic stimulation (rTMS) is an efficient intervention for alleviating cognitive symptoms in Alzheimer's disease (AD), but the optimal treatment duration for high efficacy remains unclear.ObjectiveThis study investigates the effects of 2-week and 4-week rTMS on neural network plasticity and cognitive improvement, aiming to identify the optimal treatment duration for cognitive impairment.MethodsrTMS was administered to cognitively impaired patients over 2-week and 4-week periods, exploring its effects on cognitive improvement and induced neural circuits. The study also examines the predictive value of these neural circuits for individual treatment responses.ResultsThe 4-week rTMS treatment significantly outperformed the 2-week course in improving cognitive function. Neural activity analysis identified the precuneus as a key region for episodic memory. Changes in brain regions, particularly within the default mode network (DMN), visual network (VN), and motor network (MN), were associated with cognitive improvements. Baseline functional connectivity in these regions predicted changes in general cognition (r = 0.724, p < 0.001) and episodic memory (r = 0.447, p = 0.022) after rTMS.ConclusionsExtended rTMS treatment enhances cognitive performance in cognitive impairment patients, with the 4-week course showing superior effects. Reduced connectivity in the DMN following rTMS was linked to cognitive improvements. The neural network baseline can predict patients' treatment responses.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251320124"},"PeriodicalIF":3.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TMA-93 (binding by images): Cutoffs optimization based on Alzheimer's disease biomarkers.","authors":"José Enrique Arriola-Infante, Ernesto García-Roldán, David García-Solís, Alba Marta Marín-Cabañas, Andrea Luque-Tirado, Ángela Almodóvar-Sierra, María Bernal Sánchez-Arjona, Didier Maillet, Emilio Franco-Macías","doi":"10.1177/13872877251325759","DOIUrl":"https://doi.org/10.1177/13872877251325759","url":null,"abstract":"<p><p>BackgroundWith the arrival of new disease-modifying treatments for Alzheimer's disease (AD), feasible cognitive tests, also for illiterate patients, are needed to screen those requiring deeper evaluation among individuals presenting with memory complaints. The TMA-93, a brief binding memory test, has proven useful for diagnosing early AD, and is supported by normative data that accounts for age and cognitive reserve.ObjectiveTo compare the sensitivity of different TMA-93 cutoffs in detecting AD pathology.MethodsA retrospective analysis was performed on a biobank sample of patients with confirmed AD pathology via amyloid PET or cerebrospinal fluid (CSF) biomarkers. The sensitivity of six TMA-93 cutoffs was evaluated: the 10th, 15th, and 20th percentiles based on traditional norming (TN) and regression-based norming (RBN). False negatives (FN) characteristics were also analyzed.ResultsA total of 270 AD-positive patients (96 by amyloid-PET, 174 by CSF biomarkers) were included, comprising 224 with mild cognitive impairment and 46 with mild dementia. The 15th percentile using RBN demonstrated substantial sensitivity (80.4%), higher than that of the 10th percentile, and also provided a more uniform distribution across normative groups compared to the TN approach. Higher global cognition (Mini-Mental State Examination score) and, in patients over 70, lower cognitive reserve (Cognitive Reserve Questionnaire), were linked to a greater likelihood of FN results.ConclusionsThe 15th percentile cutoff based on RBN, accounting for age and cognitive reserve, improves sensitivity for detecting AD pathology, making it a valuable screening tool for memory complaints. Future normative data from biomarker-negative subjects may enhance the sensitivity of cognitive tests.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251325759"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal fluid HSP90AA1, HSPA4, and STUB1/CHIP levels in Alzheimer's disease, mild cognitive impairment, and frontotemporal dementia.","authors":"Pelin Sordu, Merve Alaylıoğlu, Bedia Samancı, Ersel Bulu, Zeynep Ece Kaya Güleç, Başar Bilgiç, Haşmet Ayhan Hanağası, İbrahim Hakan Gürvit, Turgut Ulutin, Erdinç Dursun, Duygu Gezen-Ak","doi":"10.1177/13872877251329540","DOIUrl":"https://doi.org/10.1177/13872877251329540","url":null,"abstract":"<p><p>BackgroundThe data that we gathered from a protein-protein interaction (PPI) prediction tool, FpClass, and a limited number of studies indicated that the chaperones HSP90AA1, HSPA4, STUB1/CHIP might interact with amyloid-β (Aβ) and/or tau and could subsequently be co-released into the cerebrospinal fluid (CSF). Therefore, we investigated CSF levels of HSP90AA1, HSPA4, and STUB1/CHIP in Alzheimer's disease (AD), Non-AD mild cognitive impairment (Non-AD MCI), and frontotemporal dementia (FTD) cases.MethodsThe CSF levels of HSP90AA1, HSPA4, STUB/CHIP, and core AD biomarkers were determined by ELISA in AD (n = 90), Non-AD MCI (n = 27), FTD (n = 15), and subjective cognitive impairment (SCI) (n = 20) subjects.ResultsHSP90AA1 levels were significantly higher in AD cases compared to the SCI subjects. The CSF levels of STUB1/CHIP were significantly lower in AD, Non-AD MCI and FTD cases compared to the SCI subjects. STUB1/CHIP levels of FTD cases were significantly lower than all other groups. HSPA4 levels was correlated with core AD biomarkers (Aβ 1-42, p-Tau, t-Tau) regardless of disease. Non-<i>APOE</i> ε4 carrier FTD cases also had significantly lower STUB1/CHIP levels than other groups.ConclusionsThe STUB1/CHIP holds promise as a potential biomarker for distinguishing between SCI subjects, AD, and FTD. Furthermore, <i>APOE</i> might serve as an additional discriminatory factor that might be integrated with this chaperone for enhanced discrimination.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251329540"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"V-set and immunoglobulin domain containing 4 as a potential predictor of Alzheimer's disease and advanced aging.","authors":"Bowen Yang, Aygun Teymur, Chenling Tang, Tianfu Wu","doi":"10.1177/13872877251329463","DOIUrl":"https://doi.org/10.1177/13872877251329463","url":null,"abstract":"<p><p>BackgroundV-set and immunoglobulin domain containing 4 (VSIG4) emerges as a significant player in the immune system pathways. It has been previously identified as a potential hub gene for Alzheimer's disease (AD) and aging, underscoring its importance in understanding these conditions.ObjectiveThis study aimed to evaluate the diagnostic potential of serum VSIG4 and identify trends in serum VSIG4 in relationship with other biomarkers and neurological tests.MethodsELISA was used to measure the serum concentration of VSIG4 in AD, compared to healthy subjects. The relationship between VSIG4 levels and the age of the subjects, as well as other AD-related serum proteins and various measures of cognition was examined.ResultsVSIG4 was significantly elevated in the serum of AD patients compared to healthy controls (p = 0.0074). Significant correlations were identified between serum VSIG4 and other notable proteins related to AD and inflammation, such as total tau, neurofilament light (NfL), YKL-40, CD14, FABP3, and TNF-α. Significant correlations were also identified between VSIG4 concentration and the results of neurological tests.ConclusionsSerum VSIG4 may reflect neuroinflammation and altered lipid processing, affecting the cognitive performance of AD and aging.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251329463"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}