Journal of Alzheimer's Disease最新文献

Spanish norms focused on learning measures for the picture version of the free and cued selective reminding test with immediate recall. 西班牙语规范侧重于图片版本的自由和线索选择性提醒测试与即时回忆的学习措施。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251376906

Andrea Luque-Tirado, Ernesto García-Roldán, Melisa González-Acosta, Andrea Herrera-Pozo, Julio Hernández Mendoza, Ángela Almodóvar-Sierra, Marta Marín-Cabañas, María Bernal Sánchez-Arjona, Juan Pedro Vargas-Romero, Emilio Franco-Macías

{"title":"Spanish norms focused on learning measures for the picture version of the free and cued selective reminding test with immediate recall.","authors":"Andrea Luque-Tirado, Ernesto García-Roldán, Melisa González-Acosta, Andrea Herrera-Pozo, Julio Hernández Mendoza, Ángela Almodóvar-Sierra, Marta Marín-Cabañas, María Bernal Sánchez-Arjona, Juan Pedro Vargas-Romero, Emilio Franco-Macías","doi":"10.1177/13872877251376906","DOIUrl":"https://doi.org/10.1177/13872877251376906","url":null,"abstract":"BackgroundThe Free and Cued Selective Reminding Test (FCSRT) is a gold-standard among memory tests. Administration focused on learning measures may be more feasible for settings with limited face-to-face time per patient.ObjectiveTo obtain norms based on learning measures for the picture version of the FCSRT with Immediate Recall (pFCSRT + IR) from Spanish population.MethodsA prospective normative study. Cognitively unimpaired volunteers were systematically recruited if eligible (age ≥50, no memory complaints, and a total TMA-93 score at or above the 10th percentile). In a second and independent session, the pFCSRT-IR was administered and its free recall and total recall (learning measures) were scored (range of score: 0-48 points). If a variable showed a high ceiling effect it was dichotomized; otherwise, a regression-based method was followed.ResultsThe final sample included 257 participants. Mean age and years of schooling were 67.46 (SD = 9.42, range = 50-88) years and 10.30 (SD = 5.81, range = 0-30) years, respectively. 68.9% were females. Scores for total recall showed ceiling effect, with 90.7% of the participants scoring > 46, which allowed dichotomizing the cutoff point at 46/47 (10th percentile). Free recall scores exhibited variability and were influenced by years of schooling, as well as by an age-by-sex interaction identified in the regression analysis.ConclusionsThe study provides norms based on learning measures for using the pFCSRT + IR in Spain. The 46/47 cutoff point for total recall may be a reliable and easy-to-use measure for diagnosing memory impairment. Norms for free recall must also take an age-by-sex interaction into account.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251376906"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurovascular coupling dysfunction associated with cognition and glial fibrillary acidic protein along the Alzheimer's disease continuum. 阿尔茨海默病连续体中认知和胶质纤维酸性蛋白相关的神经血管偶联功能障碍。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251375476

Huijuan Chen, Yihao Guo, Zhanrong Zhang, Weiyuan Huang, Kun Zhang, Haodong Qin, Feiyun Wu, Tao Liu, Feng Chen

{"title":"Neurovascular coupling dysfunction associated with cognition and glial fibrillary acidic protein along the Alzheimer's disease continuum.","authors":"Huijuan Chen, Yihao Guo, Zhanrong Zhang, Weiyuan Huang, Kun Zhang, Haodong Qin, Feiyun Wu, Tao Liu, Feng Chen","doi":"10.1177/13872877251375476","DOIUrl":"https://doi.org/10.1177/13872877251375476","url":null,"abstract":"BackgroundEarly neurovascular coupling (NVC) dysfunction in Alzheimer's disease (AD) remains poorly understood despite being a key pathological feature.ObjectiveThis study aimed to investigate NVC alterations across the AD continuum, including individuals with AD, mild cognitive impairment (MCI), and cognitively normal (CN) individuals, and to examine their associations with cognitive performance and plasma biomarkers.MethodsThis study included 23 CN participants, 80 MCI, and 33 AD patients. Neuronal activity was assessed using amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo), which were derived from blood oxygen level-dependent functional magnetic resonance imaging signals, whereas cerebral blood flow (CBF) maps measured perfusion. Neurovascular coupling was quantified via the ALFF-CBF and ReHo-CBF. Group differences were evaluated using analysis of variance, and associations with cognitive scores and plasma biomarkers were analyzed.ResultsThe AD group exhibited lower ALFF-CBF coupling values in the left anterior cingulate and middle cingulate gyri compared with the CN and MCI groups. Reduced coupling values were positively correlated with Mini-Mental State Examination scores. In cognitively impaired groups, left anterior cingulate coupling was negatively correlated with plasma glial fibrillary acidic protein (GFAP) levels. AD patients showed decreased ReHo-CBF coupling in the left inferior frontal and middle temporal gyri.ConclusionsNeurovascular coupling dysfunction is significantly linked to cognitive impairment along the AD continuum. Reduced coupling values in key regions correlated with impaired cognition and higher plasma GFAP levels, underscoring vascular-metabolic and astroglial contributions. These findings support ALFF-CBF coupling as a promising non-invasive biomarker for early AD detection and disease monitoring.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251375476"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the potential of the Digits-in-Noise test as a hearing screening tool for older adults with cognitive impairment. 揭示噪音数字测试作为认知障碍老年人听力筛查工具的潜力。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251376949

Patcharaorn Limkitisupasin, Pimpanee Nilchaeng, Anthipa Chokesuwattanaskul, Sookjaroen Tangwongchai, Doris-Eva Bamiou, Nattawan Utoomprurkporn

{"title":"Unveiling the potential of the Digits-in-Noise test as a hearing screening tool for older adults with cognitive impairment.","authors":"Patcharaorn Limkitisupasin, Pimpanee Nilchaeng, Anthipa Chokesuwattanaskul, Sookjaroen Tangwongchai, Doris-Eva Bamiou, Nattawan Utoomprurkporn","doi":"10.1177/13872877251376949","DOIUrl":"https://doi.org/10.1177/13872877251376949","url":null,"abstract":"BackgroundThe Digits-in-Noise (DIN) test is recognized as a promising hearing screening tool due to its feasibility and reliability, particularly in noisy environments. Although endorsed by the World Health Organization for general population hearing screening, it has not been validated in older adults with cognitive impairment, such as mild cognitive impairment (MCI), and dementia, including Alzheimer's disease.ObjectiveTo address this gap, this study aimed to evaluate diagnostic accuracy of DIN compared to pure-tone audiometry, marking the first validation of the DIN test in this specific group.MethodsParticipants with MCI and dementia were recruited from memory clinics. Each participant underwent an audiologic evaluation, including the Hearing Handicap Inventory for Elderly, pure-tone audiometry, and smartphone-based DIN test. Additionally, the Montreal Cognitive Assessment, was administered.ResultsAmong 93 adults (mean age 71.9), an optimal speech reception threshold (SRT) cutoff of -3.5 dB yielded 90.5% sensitivity and 50% specificity for detecting moderate hearing loss. The area under the curve was 0.649 for mild hearing loss and 0.746 for moderate. A significant weak positive correlation was observed between SRT and pure tone average (ρ= 0.35, p < 0.001)ConclusionOur findings underscore the potential of the DIN test in detecting disabling hearing loss among cognitively impaired individuals, which warrants immediate hearing intervention to improve their quality of life.Trial RegistrationThai Clinical Trials Registry (TCTR20221222004), https://www.thaiclinicaltrials.org/.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251376949"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of comorbidities and chronically used medications in patients with mild cognitive impairment aged 60-74 years. 60-74岁轻度认知障碍患者的合并症和长期用药分析

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251376674

Andrzej Bożek, Aleksandra Spyra, Natalia Tekiela, Maksymilian Dobosz, Aleksandra Mitka, Martyna Miodońska

引用次数: 0

Long-term exposure to air pollution and cognitive aging: Findings from a United States cohort of older adults. 长期暴露于空气污染和认知老化：来自美国老年人队列的研究结果。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251373050

Sindana D Ilango, Claire E Adam, Xinmei Huang, Cindy S Leary, Erin O Semmens, Annette L Fitzpatrick, Paul K Crane, Joel D Kaufman, Anjum Hajat

{"title":"Long-term exposure to air pollution and cognitive aging: Findings from a United States cohort of older adults.","authors":"Sindana D Ilango, Claire E Adam, Xinmei Huang, Cindy S Leary, Erin O Semmens, Annette L Fitzpatrick, Paul K Crane, Joel D Kaufman, Anjum Hajat","doi":"10.1177/13872877251373050","DOIUrl":"https://doi.org/10.1177/13872877251373050","url":null,"abstract":"BackgroundGrowing epidemiologic evidence suggests long-term exposure to air pollution increases the risk of Alzheimer's disease and related dementias (ADRD) in older adults but research on its effect on early indicators of ADRD is limited.ObjectiveWe examined the effect of fine particulate matter (PM2.5) and nitrogen dioxide (NO2) on cognitive performance and decline in a cohort of older adults.MethodsThis analysis draws from the Ginkgo Evaluation of Memory Study, a clinical trial aimed at understanding ADRD prevention. Participants aged 75 years and older completed an annual neuropsychological battery for up to 8 years. Air pollution was estimated using fine-scale models and accounted for residential history. Cognitive performance at baseline and trajectories of cognitive function across levels of air pollution were estimated using linear mixed regression models. Longitudinal analyses incorporated inverse probability weights to account for differential selection across visits.ResultsThis study included 3044 individuals. Exposure to PM2.5 was associated with slightly worse performance at intercepts for all domains. Higher exposure was not associated with faster declines in cognitive performance over follow-up. Results for NO2 follow a similar pattern.ConclusionsFindings support associations between exposure to higher concentrations of air pollution and worse cognitive performance at baseline, but not cognitive decline.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251373050"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive performance and blood biomarkers: Insights into their relationship and predicting high Amyloid Probability Score in cognitively impaired older adults. 认知表现和血液生物标志物：认知障碍老年人的关系和高淀粉样蛋白概率评分预测。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251372958

Thi Quynh Tho Chu, Kohei Morimoto, Hisatomo Kowa

{"title":"Cognitive performance and blood biomarkers: Insights into their relationship and predicting high Amyloid Probability Score in cognitively impaired older adults.","authors":"Thi Quynh Tho Chu, Kohei Morimoto, Hisatomo Kowa","doi":"10.1177/13872877251372958","DOIUrl":"https://doi.org/10.1177/13872877251372958","url":null,"abstract":"BackgroundUnderstanding associations between cognitive performance and blood biomarkers supports diagnosis and treatment of Alzheimer's disease (AD); however, this relationship remains unclear.ObjectiveExploring associations between the Amyloid Probability Score (APS; PrecivityAD® blood test) and cognitive performance, and between Mini-Mental State Examination (MMSE) and Cogstate Brief Battery (CBB) in cognitively impaired older adults.MethodsOlder adults aged ≥ 60 years with MMSE from 10 to 27, recruited from a cohort in Japan, were assessed with the CBB, and plasma biomarkers to calculate APS. We used Spearman correlation to explore relationships; receiver operating curves and cross-validation to identify the best model for predicting high APS.ResultsAmong 46 participants (mean age = 78.3 ± 5.9; mean MMSE = 20.3 ± 4.6), 39.1% did not complete at least one test in the CBB. Lower MMSE were observed in those who were non-completers. MMSE correlated with Detection (Psychomotor function), Identification (Attention), and their composite (r = 0.34-0.52; p < 0.05; 95%CI excluding null value). Higher APS was seen in those who did not complete the One Card Learning (OCL-visual learning and short-term memory). The best model for predicting High APS included OCL completion status, MMSE and Years of Education, achieving accuracy = 0.808 and kappa = 0.606 in participants with MMSE < 21.ConclusionsOur findings suggest a consideration of incompletion when using CBB in cognitively impaired older adults and a potential approach to differentiate High APS group among those with moderate to severe dementia based on visual learning and short-term memory, global cognition and education level.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251372958"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gonadal hormones and aquaporin-4: Preclinical insights into glymphatic regulation and amyloid clearance. 性腺激素和水通道蛋白-4:glymatic调节和淀粉样蛋白清除的临床前见解。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251377790

Muhammed Zahid Sahin, Abdulkadir Yildirim

{"title":"Gonadal hormones and aquaporin-4: Preclinical insights into glymphatic regulation and amyloid clearance.","authors":"Muhammed Zahid Sahin, Abdulkadir Yildirim","doi":"10.1177/13872877251377790","DOIUrl":"https://doi.org/10.1177/13872877251377790","url":null,"abstract":"Aquaporin-4 (AQP4)-mediated water transport at astrocytic end-feet is pivotal for glymphatic clearance, a process increasingly recognized as a determinant of brain health and resilience to neurodegeneration. Nevertheless, existing literature has not yet systematically clarified how sex hormones influence AQP4 biology and, in turn, glymphatic efficiency, leaving a critical gap in our understanding of sex-specific vulnerability to disorders such as Alzheimer's disease. To address this gap, we investigated how gonadal hormones influence AQP4 expression and polarity within the context of neuroinflammatory processes, drawing on evidence from preclinical models. We conducted a comprehensive review of in vivo and in vitro studies across ischemic stroke, traumatic brain injury, hypoxia-ischemia, osmotic stress, and viral neuroinflammation models, extracting standardized data on hormonal status, AQP4 metrics, neuroinflammatory markers, and fluid-clearance outcomes. The collated findings reveal that loss of estrogen, progesterone, or testosterone amplifies microgliosis, NF-κB activation, cytokine release (IFN-γ, IL-6, IL-8), and AQP4 mislocalization, whereas physiological hormone replacement reverses these changes, restores AQP4 polarity, and stabilizes the blood-brain barrier. These results indicate that sex-dependent regulation of AQP4 and glymphatic flow is a plausible contributor to the higher incidence and faster progression of Alzheimer's disease in postmenopausal women. Our synthesis underscores the need for real-time glymphatic imaging combined with targeted hormonal or anti-inflammatory interventions to determine whether re-establishing proper hormone signaling or AQP4 polarity can slow proteopathic accumulation and modify disease trajectories.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251377790"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cross-sectional associations between enlarged perivascular spaces and mild behavioral impairment in dementia-free older adults. 无痴呆老年人血管周围空间增大与轻度行为障碍的横断面关联。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251372566

Dinithi Mudalige, Dylan X Guan, Graham A McLeod, Eric E Smith, Aravind Ganesh, Zahinoor Ismail

{"title":"The cross-sectional associations between enlarged perivascular spaces and mild behavioral impairment in dementia-free older adults.","authors":"Dinithi Mudalige, Dylan X Guan, Graham A McLeod, Eric E Smith, Aravind Ganesh, Zahinoor Ismail","doi":"10.1177/13872877251372566","DOIUrl":"https://doi.org/10.1177/13872877251372566","url":null,"abstract":"BackgroundEnlarged perivascular spaces (EPVS) and mild behavioral impairment (MBI) are associated with greater dementia risk.ObjectiveWe investigated cross-sectional associations between EPVS burden and MBI presence and symptom severity.MethodsParticipants were dementia-free older adults in the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) study. EPVS were assessed using a validated visual rating scale applied to T2-weighted magnetic resonance imaging. MBI was measured using the informant-reported MBI Checklist (MBI-C) with a cut-point of >5 for MBI presence. Multivariable logistic and zero-inflated negative binomial regressions modelled EPVS associations with MBI presence and symptom severity, respectively, adjusting for age, education, Montreal Cognitive Assessment score, and presence of hypertension with an EPVS*sex interaction term.ResultsAmong 363 participants (52.9% female), every 1-point rise in total EPVS score was associated with 1.28-fold greater odds of having MBI (95%CI:1.06-1.53, p = 0.009). When examining regional EPVS burden, those with higher centrum semiovale scores had greater odds of MBI (aOR = 1.47, 95%CI:1.08-2.00, p = 0.01), but this association was not significant for the basal ganglia (aOR = 1.37, 95%CI:0.95-1.97, p = 0.09) or midbrain (aOR = 1.49, 95%CI:0.80-2.79, p = 0.21). Total and regional EPVS scores were not associated with MBI symptom severity. None of the associations were moderated by sex.ConclusionsOlder adults with greater global and centrum semiovale EPVS burden are more likely to have MBI. These findings suggest that early microvascular pathology may contribute to later-life emergent and persistent behavioral symptoms, although longitudinal data are required, along with other indicators of vascular pathology.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251372566"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay of Glut1 alteration and Alzheimer's disease: A narrative review on glucose transport and energy metabolism. Glut1改变与阿尔茨海默病的相互作用：葡萄糖转运和能量代谢的叙述性综述。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251377793

Sodiq Fakorede, Toheeb Ayodeji Sodiq, Abayomi Oyeyemi Ajagbe, Adewale James Adeleke, Okeoghene Marcel Edafetanure-Ibeh, Taiwo Ayomide Awobona, Abdullahi Tunde Aborode

{"title":"Interplay of Glut1 alteration and Alzheimer's disease: A narrative review on glucose transport and energy metabolism.","authors":"Sodiq Fakorede, Toheeb Ayodeji Sodiq, Abayomi Oyeyemi Ajagbe, Adewale James Adeleke, Okeoghene Marcel Edafetanure-Ibeh, Taiwo Ayomide Awobona, Abdullahi Tunde Aborode","doi":"10.1177/13872877251377793","DOIUrl":"https://doi.org/10.1177/13872877251377793","url":null,"abstract":"Alzheimer's disease (AD) is a prevalent neurodegenerative disorder primarily affecting the aging population, characterized by progressive cognitive decline. Traditional models of AD pathogenesis, including the amyloid cascade and tau hypotheses, have not yielded definitive therapeutic breakthroughs. Emerging research suggests that metabolic dysfunction, particularly in glucose transport, plays a central role in AD progression. The glucose transporter 1 (GLUT1), which facilitates glucose entry across the blood-brain barrier, is crucial for maintaining brain energy metabolism. Studies have shown reduced GLUT1 expression in AD brains, impairing cerebral glucose uptake and contributing to neuronal dysfunction and neurodegeneration. This review synthesizes current evidence on the interplay between GLUT1 alteration and AD, highlighting how disruptions in glucose transport can exacerbate the disease's neuropathological features, including amyloid and tau pathologies. Furthermore, we explore potential therapeutic strategies aimed at restoring GLUT1 function, such as gene therapy, ketogenic diets, and small molecules that enhance GLUT1 expression. These approaches may offer promising avenues to mitigate the metabolic dysfunction driving AD and improve patient outcomes. This work underscores the importance of integrating metabolic insights into AD research to develop innovative therapeutic targets and interventions.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251377793"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The bidirectional effect of attention on gamma sensory stimulation: 40 Hz entrainment is weakened by externally-induced distraction but enhanced by internally-induced distraction. 注意对感官刺激的双向效应：40 Hz夹带被外源性分心削弱，而被内源性分心增强。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-09-12 DOI: 10.1177/13872877251376383

Shih-Chiang Ke, Yu-Hui Lo, Philip Tseng

{"title":"The bidirectional effect of attention on gamma sensory stimulation: 40 Hz entrainment is weakened by externally-induced distraction but enhanced by internally-induced distraction.","authors":"Shih-Chiang Ke, Yu-Hui Lo, Philip Tseng","doi":"10.1177/13872877251376383","DOIUrl":"https://doi.org/10.1177/13872877251376383","url":null,"abstract":"BackgroundForty-hertz gamma sensory entrainment has been shown to influence neural oscillations, reduce amyloid-β plaques and tau phosphorylation, and improve cognitive functioning in Alzheimer's disease. However, the role of the user's attentional states in modulating this entrainment effect remains poorly understood.ObjectiveHere we manipulated users' attentional state to investigate the effect of focused vs. distracted attention on 40 Hz entrainment.MethodsDuring 40 Hz auditory stimulation, participants' attentional states were manipulated to 3 attentional conditions: (1) attentive (i.e., attention directed towards 40 Hz clicking sound), (2) internally distracted (attention directed towards memory/thought), and (3) externally distracted (i.e., attention directed towards a podcast interview that is overlaid with 40 Hz auditory stimulation).ResultsWe observed strong 40 Hz oscillation in the attentive condition, and even stronger oscillation in the internal distraction condition, but minimal activation in the external distraction condition. These patterns are possibly driven by internally-generated stochastic resonance in the internal distraction condition, and sensory competition in the external distraction condition.ConclusionsIn real-world applications, researchers should exercise caution when introducing features aimed at minimizing user boredom and discomfort, as these may create sensory competition and reduce entrainment. Instead, features that guide users' internal attention may offer a promising direction for future research and implementation. Large-scale studies that employ larger sample size and more diverse participant pool are warranted to verify the findings reported here for better market implementations of the 40 Hz sensory entrainment.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251376383"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0