Improved cognitive function, efficiency, saccadic eye movement, and depressive symptoms in mild cognitive impairment with transcranial photobiomodulation.

IF 3.1 3区 医学 Q2 NEUROSCIENCES
Tsz-Lok Lee, Timothy Chi-Yui Kwok, Linda Chiu-Wa Lam, Helene Hoi-Lam Fung, Mei-Chun Cheung, Yvonne Ming Yee Han, Agnes Sui-Yin Chan
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Abstract

BackgroundMild cognitive impairment (MCI) is a critical stage with higher progression to Alzheimer's disease, yet effective interventions are still lacking.ObjectiveSome empirical studies have shown that transcranial photobiomodulation (tPBM) may be effective in enhancing cognitive function. To further investigate its effectiveness, a controlled experiment was conducted.MethodsIn this study, 36 community-dwelling older adults with MCI were assigned to receive either real tPBM (experimental group; n = 25) and others without intervention (control group; n = 11) over three weeks. Participants underwent comprehensive assessments before and after the intervention, including neuropsychological tests, measurements of oxygenated hemoglobin (HbO) using function near-infrared spectroscopy during a visual working memory task, saccadic movement measurement using an eye-tracking device, and a questionnaire assessing depressive symptoms.ResultsCompared to the control group, the experimental group demonstrated significant improvements. They showed enhanced cognitive efficiency, as evidenced by improved visual working memory performance, reduced anti-saccade latency, higher scores in the Montreal Cognitive Assessment, and faster completion time in the Shape Trail Test B. In addition, significantly more participants in the experimental group showed improvement in depressive symptoms after the intervention.ConclusionsThese findings provide preliminary evidence that tPBM may effectively improve neuropsychological, physiological, and psychological outcomes in individuals with MCI. This trial was registered in the Chinese Clinical Trial Registry (http://www.chictr.org.cn, registration number: ChiCTR2400090408).

经颅光生物调节改善轻度认知障碍患者的认知功能、效率、跳眼运动和抑郁症状。
轻度认知障碍(MCI)是阿尔茨海默病发展的关键阶段,但目前仍缺乏有效的干预措施。目的一些实证研究表明经颅光生物调节(tPBM)可能具有增强认知功能的作用。为了进一步验证其有效性,进行了对照实验。在这项研究中,36名社区居住的轻度认知障碍老年人被分配到接受真正的tPBM(实验组;N = 25)和未经干预者(对照组;N = 11)超过三周。参与者在干预前后接受了全面的评估,包括神经心理测试、在视觉工作记忆任务期间使用功能近红外光谱测量氧合血红蛋白(HbO)、使用眼动追踪设备测量眼跳运动以及评估抑郁症状的问卷调查。结果与对照组相比,实验组有明显改善。他们表现出增强的认知效率,如改善的视觉工作记忆表现,减少的抗扫视潜伏期,蒙特利尔认知评估得分更高,形状轨迹测试b的完成时间更快。此外,实验组中更多的参与者在干预后表现出抑郁症状的改善。结论tPBM可有效改善轻度认知损伤患者的神经心理、生理和心理预后。本试验已在中国临床试验注册中心注册(http://www.chictr.org.cn,注册号:ChiCTR2400090408)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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