Application of the Cogstate Brief Battery in assessing cognitive function in older Japanese individuals.

IF 3.1 3区 医学 Q2 NEUROSCIENCES
Takuya Ataka, Noriyuki Kimura
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引用次数: 0

Abstract

BackgroundAccurate and simple detection of cognitive decline is important for the prediction of dementia and identification of drug indications. The Cogstate Brief Battery (CBB) is useful in assessing cognitive function during the preclinical and mild cognitive impairment stages. However, whether it is beneficial for assessing brain function in older Japanese adults remains unclear.ObjectiveThis study aimed to assess the association of the CBB score with those of traditional cognitive tests and brain imaging in assessing cognitive function in older Japanese adults with normal cognitive function and those with mild cognitive impairment.MethodsCommunity-dwelling older adults in Usuki city underwent CBB, traditional cognitive tests, magnetic resonance imaging, and amyloid positron emission tomography. The association of the CBB score with the Japanese version of the Montreal Cognitive Assessment (MoCA-J), Japanese version of Mini-Mental State Examination (MMSE), hippocampal atrophy on magnetic resonance imaging, and brain amyloid deposition on 11C-Pittsburgh compound-B positron emission tomography was examined.ResultsIn total, 170 participants were included in this study. Among them, 59 were positive for the C-Pittsburgh compound-B. The CBB score was significantly associated with the MoCA-J and MMSE score in all patients. Further, it was significantly associated with hippocampal atrophy in the amyloid-positive group.ConclusionsThe CBB is associated with the MoCA-J and MMSE scores and may thus be a useful tool for the assessing cognitive decline in Japanese older adults.

认知状态简短电池在日本老年人认知功能评估中的应用。
背景准确、简单地检测认知能力下降对于预测痴呆和确定药物适应症非常重要。认知状态简短电池(CBB)在评估临床前和轻度认知障碍阶段的认知功能是有用的。然而,对于评估日本老年人的大脑功能是否有益仍不清楚。目的探讨认知功能正常和轻度认知障碍的日本老年人的认知功能评估中,CBB评分与传统认知测试和脑成像评分的相关性。方法对臼市社区老年人进行CBB、传统认知测试、磁共振成像和淀粉样正电子发射断层扫描。探讨CBB评分与日文版蒙特利尔认知评估(MoCA-J)、日文版迷你精神状态检查(MMSE)、磁共振海马萎缩、11C-Pittsburgh化合物- b正电子发射断层扫描(11C-Pittsburgh复合物- b)脑淀粉样蛋白沉积的相关性。结果本研究共纳入170名受试者。其中59例C-Pittsburgh - b阳性。所有患者的CBB评分与MoCA-J和MMSE评分显著相关。此外,在淀粉样蛋白阳性组,它与海马萎缩显著相关。结论CBB与MoCA-J和MMSE评分相关,因此可能是评估日本老年人认知能力下降的有用工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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