Journal of Alzheimer's Disease最新文献

{"title":"Validation of the Brief Assessment of Impaired Cognition and Brief Assessment of Impaired Cognition Questionnaire in a multicultural memory clinic sample across six European countries.","authors":"T Rune Nielsen, Kasper Jørgensen, Marco Canevelli, Simone Pomati, Alfonso Delgado-Álvarez, Sanne Franzen, Alvaro Lozano-Ruiz, Maria Özden, Juliette Palisson, Naaheed Mukadam, Gunhild Waldemar","doi":"10.1177/13872877251320259","DOIUrl":"https://doi.org/10.1177/13872877251320259","url":null,"abstract":"<p><p>BackgroundWith the changing demographic landscape in most countries worldwide, accurate and brief culture-sensitive case-finding instruments are needed to identify patients with possible cognitive disorders.ObjectiveTo investigate the discriminative validity of the Brief Assessment of Impaired Cognition (BASIC) and BASIC Questionnaire (BASIC-Q) in a multicultural memory clinic sample across six European countries.MethodsThe study was a European cross-sectional multi-center study. Receiver operating characteristic curve analysis was used to examine discriminative validity of BASIC and BASIC-Q in identifying cognitive impairment (mild cognitive impairment (MCI) or dementia) as compared to specialist diagnosis. Regression analysis was used to assess the influence of sociodemographic variables and assessment in a second language on scores.ResultsThe study included a total of 479 participants of which 169 (36%) had immigrant background. BASIC and BASIC-Q had high diagnostic accuracy for cognitive impairment (MCI or dementia) with areas under the curve (AUC) of 0.93 and 0.92, respectively. Age had a significant, but small effect on BASIC, while both BASIC and BASIC-Q were unaffected by sex, education, immigrant status, and assessment in a second language. Among patients with affective/anxiety disorder, 80% scored below cutoff for cognitive impairment on BASIC and 94% on BASIC-Q. However, applying an Objective Performance vs. Subjective Complaints ratio to differentiate between patients with cognitive impairment and affective/anxiety disorder resulted in high overall classification accuracies, with AUC values of 0.80 and 0.74, respectively.ConclusionsThe present study suggests that BASIC and BASIC-Q are valid brief case-finding instruments for cognitive impairment in a multicultural setting.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251320259"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of dietary protein and amino acid intakes with disability-adjusted life years for Alzheimer's disease in Japanese people.","authors":"Kazuko Ishikawa-Takata, Kazuki Fujiwara, Takayuki Tanaka, Keiji Nakamura, Hisamine Kobayashi, Shinobu Okada","doi":"10.1177/13872877251319535","DOIUrl":"https://doi.org/10.1177/13872877251319535","url":null,"abstract":"<p><p>BackgroundThe number of patients with dementia is increasing worldwide. In Japan, dementia is the most significant reason recognized for people requiring nursing care. Protein is one of the possible preventive nutrients for dementia; however, adequate intake levels can differ according to usual protein intakes and protein sources.ObjectiveThis study examined the relationships between disability-adjusted life years (DALYs) for Alzheimer's disease and protein or amino acid intakes.MethodsGlobal Burden of Disease Study data (DALYs for each sex and age group in each year) and de-identified individual records from the National Health and Nutrition Survey Japan (data from 46,831 subjects) from 2001 to 2019 were used. Multiple regression analyses were conducted to assess the relationships between DALYs and protein or amino acid intakes with lifestyle factors and sociodemographic index as confounding factors.ResultsHigher protein-to-energy ratios were correlated with lower DALYs in women in their 70 s (partial regression coefficient [Coeff.] = -349.488, <i>p</i> = 0.034), in men in their 60 s (Coeff. = -51.484), and in both sexes combined in their 60 s (Coeff. = -26.696, <i>p</i> = 0.015) even after adjusting for other possible nutrient intakes. Additionally, elevated isoleucine, lysine, tyrosine, histidine, arginine, alanine, asparagine, and glycine levels were correlated with lower DALYs in women in their 70 s (Coeff. = -2.752 to -0.141).ConclusionsAdequate protein and specific amino acid intakes may be associated with DALYs for Alzheimer's disease.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251319535"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domestic violence in Lewy body dementia: A national study.","authors":"Emmanuel Morain, Alexandra Fayel, Philippe De Linares, Julien Dumurgier, Emmanuel Cognat, Claire Paquet","doi":"10.1177/13872877251325584","DOIUrl":"https://doi.org/10.1177/13872877251325584","url":null,"abstract":"<p><p>A descriptive study using a transversal national online survey to evaluate the prevalence and characteristics of behavioral and psychological symptoms (BPSD) of dementia with Lewy bodies (DLB), and specifically, the perpetration of violent acts against primary caregivers. 196 responses, obtained in one month, were analyzed. Delirium, hallucinations, anxiety, and apathy were the most frequently reported BPSD symptoms (over 80% of responders). Primary caregivers expressed the highest degree of distress from agitation and aggressive behavior. Moreover, 45.9% of primary caregivers reported being the target of violent behaviors from DLB patients. No statistical association was found between the presence of BPSD and violent acts.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251325584"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project.","authors":"Dongyu Wang, Alexandra Scalici, Yanbing Wang, Honghuang Lin, Achilleas Pitsillides, Nancy Heard-Costa, Carlos Cruchaga, Ellen Ziegemeier, Joshua C Bis, Myriam Fornage, Eric Boerwinkle, Philip L De Jager, Ellen Wijsman, Josée Dupuis, Alan E Renton, Sudha Seshadri, Alison M Goate, Anita L DeStefano, Gina M Peloso","doi":"10.1177/13872877251320375","DOIUrl":"10.1177/13872877251320375","url":null,"abstract":"<p><p>BackgroundPrior studies examined variants within presenilin-2 (<i>PSEN2</i>), presenilin-1 (<i>PSEN1</i>), and amyloid precursor protein (<i>APP</i>) genes. However, previously-reported clinically-relevant variants and other predicted damaging missense (DM) variants have not been characterized in a newer release of the Alzheimer's Disease Sequencing Project (ADSP).ObjectiveTo characterize previously-reported clinically-relevant variants and DM variants in <i>PSEN2, PSEN1, APP</i> within the participants from the ADSP.MethodsWe identified rare variants (MAF < 1%) in <i>PSEN2</i>, <i>PSEN1,</i> and <i>APP</i> in 14,641 individuals with whole genome sequencing and 16,849 individuals with whole exome sequencing available (N_total= 31,490). We additionally curated variants from ClinVar, OMIM, and Alzforum and report carriers of variants in clinical databases as well as predicted DM variants in these genes.ResultsWe detected 31 previously-reported clinically-relevant variants with alternate alleles observed within the ADSP: 4 variants in <i>PSEN2</i>, 25 in <i>PSEN1</i>, and 2 in <i>APP</i>. The overall variant carrier rate for the 31 clinically-relevant variants in the ADSP was 0.3%. We observed that 79.5% of the variant carriers were cases compared to 3.9% were controls. In those with AD, the mean age of onset of AD among carriers of these clinically-relevant variants was 19.6 ± 1.4 years earlier compared with noncarriers (p = 7.8 × 10^-57). Additionally, we identified 197 rare variants (MAF < 1%) within ADSP participants not reported in known clinical databases.ConclusionsA small proportion of individuals in the ADSP are carriers of a previously-reported clinically-relevant variant allele for AD and these participants have significantly earlier age of AD onset compared to noncarriers.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251320375"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular dysfunction in Alzheimer's disease: Exploring the potential of aerobic and resistance exercises as therapeutic strategies.","authors":"Larissa Alves, Debora Hashiguchi, Cássio Morais Loss, Henriette van Praag, Beatriz Monteiro Longo","doi":"10.1177/13872877251321118","DOIUrl":"https://doi.org/10.1177/13872877251321118","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the leading cause of morbidity and mortality worldwide, as a result of cognitive decline and neurological dysfunction. In AD, reduced cerebral blood flow and impaired vascularization result from capillary bed degeneration and decreased angiogenesis, as observed in both patients and animal models. Physical exercise is recognized as a potential intervention to delay AD progression and reduce disease risk. While most studies have focused on the benefits of aerobic exercise (AE), emerging evidence suggests that resistance exercise (RE) also exerts positive effects on overall health and cognitive function in aging and AD. However, a notable gap in knowledge remains regarding the effects of RE on cerebral blood flow and vascular structure. This review explores the processes by which AE and RE influence brain vascularization in aging and AD, including blood flow, endothelial function, angiogenesis and neurotrophic factor levels. Based on pre-clinical and clinical studies, we conclude that both AE and RE contribute to improved cerebral blood flow and vascular function, promoting vascular repair in the aging and AD-affected brain. By examining the relationship between exercise modalities and brain vascularization, this review expands knowledge regarding the processes underlying the neuroprotective effects of exercise in neurodegenerative and aging conditions.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251321118"},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting future risk of developing cognitive impairment using ambulatory sleep EEG: Integrating univariate analysis and multivariate information theory approach.","authors":"Shahab Haghayegh, Ruben Herzog, David A Bennett, Susan Redline, Kristine Yaffe, Katie L Stone, Agustin Ibáñez, Kun Hu","doi":"10.1177/13872877251319742","DOIUrl":"10.1177/13872877251319742","url":null,"abstract":"<p><p>BackgroundEarly identification of individuals at risk for cognitive impairment is crucial, as the preclinical phase offers an opportunity for interventions to slow disease progression and improve outcomes.ObjectiveWhile sleep electroencephalography (EEG) has shown significant promise in detecting cognitive impairment, this study aims to 1) develop and validate overnight EEG biomarkers for the prediction of future cognitive impairment risk, 2) assess their predictive performance within 5 years, and 3) explore the feasibility of using wearable, low-density EEG devices for convenient at-home monitoring.MethodsOvernight polysomnography was performed on 281 cognitively normal women in the Study of Osteoporotic Fractures (SOF). Cognitive reassessments were conducted approximately five years later. Features such as relative EEG power across different frequency bands and channel interactions, quantified using generalized mutual information measures, were extracted and used as inputs for machine learning models. Binary classification models distinguished participants who developed cognitive impairment from those who remained cognitively normal. Optimal feature subsets and frequency bands for classiffiation were identifed, with additional analyses testing the contribution of demographic data, sleep macrostructure, and <i>APOE</i> genotype.ResultsThe optimal model, utilizing univariate and multivariate EEG features, achieved an AUC of 0.76. Features from the N3 sleep stage and gamma band exhibited the largest effect sizes. Adding demographics, sleep macrostructure, and <i>APOE</i> genotype did not enhance performance.ConclusionsOvernight EEG analyses demonstrate a promising, cost-effective approach for early cognitive impairment risk assessment. Larger studies with more diverse populations are required to validate and expand these findings in diverse populations.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251319742"},"PeriodicalIF":3.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise on older adults with mild cognitive impairment: A systematic review and network meta-analysis.","authors":"Mingyuan Jia, Fengting Hu, Yuxuan Hui, Jin Peng, Weiran Wang, Jia Zhang","doi":"10.1177/13872877251321176","DOIUrl":"https://doi.org/10.1177/13872877251321176","url":null,"abstract":"<p><p><b>Background:</b> Mild cognitive impairment (MCI) represents a transitional stage between normal aging and Alzheimer's disease (AD), with a significantly elevated risk of progressing to AD. In recent years, accumulating evidence has indicated that exercise interventions may mitigate cognitive decline in individuals with MCI and reduce the risk of conversion to AD, potentially through mechanisms such as enhancing cerebral blood flow and promoting neuroplasticity. <b>Objective:</b> To explore which type of exercise is most effective in improving global cognition in older adults with MCI and to investigate whether exercise can enhance their balance abilities. <b>Methods:</b> Randomized controlled trials were retrieved from four databases. Stata software was used for Network Meta-Analysis and traditional meta-analysis. <b>Results:</b> A total of 33 studies were included, of which 28 were used to determine the best exercise modality. The results indicated that multicomponent exercise (SUCRA = 76.5%) and moderate-intensity aerobic exercise (SUCRA = 73.6%) are two effective modalities. The results of the traditional meta-analysis showed that exercise combined with cognitive training, moderate-intensity aerobic exercise, resistance exercise, and land-based kayaking training can improve balance ability. <b>Conclusions:</b> Multicomponent exercise may be the optimal exercise modality for enhancing global cognition in older adults with MCI, and various exercise modalities can improve balance abilities. However, more studies with larger sample sizes and higher quality are needed to provide further evidence.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251321176"},"PeriodicalIF":3.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal magnetic resonance imaging analysis of early mild cognitive impairment.","authors":"Shuai Xu, Yingao Fan, Chenglu Mao, Zheqi Hu, Zhiyuan Yang, Longjie Qu, Yun Xu, Linjie Yu, Xiaolei Zhu","doi":"10.1177/13872877251321187","DOIUrl":"https://doi.org/10.1177/13872877251321187","url":null,"abstract":"<p><strong>Background: </strong>Early mild cognitive impairment (EMCI) represents a prodromal stage of dementia, and early detection is crucial for delaying dementia progression. However, accurately identifying its neuroimaging features remains challenging.</p><p><strong>Objective: </strong>To comprehensively evaluate structural and functional neuroimaging changes in EMCI using multimodal magnetic resonance imaging (MRI) techniques.</p><p><strong>Methods: </strong>One hundred and eleven participants were included from the Alzheimer's Disease Neuroimaging Initiative (ADNI): 36 with cognitively normal (CN), 30 with EMCI, 32 with late mild cognitive impairment (LMCI), and 13 with Alzheimer's disease (AD). FreeSurfer software was employed to segment hippocampal and amygdala subregions. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), and functional connectivity were processed using Data Processing & Analysis for Brain Imaging toolbox. Graph Theoretical Network Analysis toolbox was utilized to evaluate global functional network.</p><p><strong>Results: </strong>The volume of most hippocampal and amygdala subregions was decreased in AD group than those of EMCI group in structural MRI. Significant differences were found between EMCI and AD group in fALFF (right insula) and ReHo (bilateral caudate regions). EMCI group exhibited stronger functional connectivity between left hippocampus and right inferior temporal gyrus (compared to CN), left inferior temporal gyrus (compared to LMCI), and cerebellum crus 8 (compared to AD). EMCI group exhibited stronger connectivity between right hippocampus and left anterior cingulate gyrus compared to AD. Network metrics showed no significant differences among these groups, but all exhibited small-world properties.</p><p><strong>Conclusions: </strong>Multimodal MRI analysis revealed the neuroimaging characteristics of EMCI and promoted the understanding of the mechanisms underlying neuroimaging changes in EMCI.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251321187"},"PeriodicalIF":3.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measures of retinal health successfully capture risk for Alzheimer's disease and related dementias at midlife.","authors":"Ashleigh Barrett-Young, Aaron Reuben, Avshalom Caspi, Kirsten Cheyne, David Ireland, Jesse Kokaua, Sandhya Ramrakha, Yih-Chung Tham, Reremoana Theodore, Graham Wilson, Tien Yin Wong, Terrie Moffitt","doi":"10.1177/13872877251321114","DOIUrl":"https://doi.org/10.1177/13872877251321114","url":null,"abstract":"<p><strong>Background: </strong>Identification of at-risk individuals who would benefit from early intervention for Alzheimer's disease and related dementias (ADRD) is critical as new treatments are developed. Measures of retinal health could offer accessible and low-cost indication of pre-morbid disease risk, but their association with ADRD risk is unknown.</p><p><strong>Objective: </strong>To determine whether midlife retinal neuronal and microvascular measures are associated with ADRD risk-index scores and individual domains of ADRD risk.</p><p><strong>Methods: </strong>Data were from the Dunedin Multidisciplinary Health and Development Study, a population-representative longitudinal New Zealand-based birth cohort study. 94.1% (N = 938) of living Study members were seen at age 45 (2017-2019). Retinal neuronal (retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL)) and microvascular (arterioles and venules) measures were used as predictors. Outcome measures were four top ADRD risk indexes (CAIDE, LIBRA, Lancet, and ADU-ADRI), and a comprehensive midlife ADRD risk index, the DunedinARB.</p><p><strong>Results: </strong>Poorer retinal microvascular health (narrower arterioles and wider venules) was associated with greater ADRD risk (βs = 0.16-0.31; <i>p</i>s < 0.001). Thinner RNFL was modestly associated with higher ADRD risk (βs = 0.05-0.08; <i>p</i>s = 0.02-0.13). Follow-up tests of distinct domains of ADRD risk indicated that while RNFL associations reflected cardiometabolic risk only, microvascular measures were associated with diverse ADRD risk factors.</p><p><strong>Conclusions: </strong>Measures of retinal health, particularly microvascular measures, successfully capture ADRD risk across several domains of known risk factors, even at the young midlife age of 45 years. Retinal microvascular imaging may be an accessible, scalable, and relatively low-cost method of assessing ADRD risk among middle-aged adults.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251321114"},"PeriodicalIF":3.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic geroscience and Alzheimer's disease: The pleiotropy is the point!","authors":"Michelle Shardell, Chixiang Chen","doi":"10.1177/13872877251321182","DOIUrl":"10.1177/13872877251321182","url":null,"abstract":"<p><p>Geroscience aims to understand how the biology of aging serves as a shared contributor to multiple age-related health conditions. Genetic variants that influence multiple traits are said to exert pleiotropic effects. The study by Pan and colleagues applied a modern statistical model to identify genetic variants with potentially pleiotropic effects by assessing their joint association with Alzheimer's disease and related dementias and another age-related comorbidity (e.g., coronary heart disease, hyperlipidemia, cancer). Motivated by Pan and colleagues, this commentary introduces the concept of genetic geroscience as a paradigm for identifying genetic variants with potentially pleotropic effects on multiple age-related health conditions.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251321182"},"PeriodicalIF":3.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}