Journal of Alzheimer's Disease最新文献

{"title":"Relationship between body composition and mortality in older patients with mild cognitive impairment and Alzheimer's disease: NCGG-STORIES.","authors":"Kazuaki Uchida, Taiki Sugimoto, Takeshi Nakagawa, Taiji Noguchi, Ayane Komatsu, Rei Ono, Yoko Yokoyama, Ayaka Onoyama, Takashi Sakurai, Tami Saito","doi":"10.1177/13872877261476079","DOIUrl":"10.1177/13872877261476079","url":null,"abstract":"<p><p>BackgroundAlthough a lower body mass index (BMI) has been identified as a prognostic risk factor among older adults with cognitive impairment, it remains unclear which body composition are associated with prognosis.ObjectiveThis study investigated the relationship between body composition and mortality in older adults with mild cognitive impairment (MCI) and Alzheimer's disease (AD).MethodsThis longitudinal study, using data from a memory clinic in Japan, included patients aged ≥65 years who were clinically diagnosed with MCI or AD. Mortality data (date and cause of death) were obtained using a proxy questionnaire. Body composition (muscle mass, fat-free mass, fat mass, %FM) was measured using bioelectrical impedance analysis, and muscle mass index (MMI), fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Body composition index was divided into tertiles (lowest, middle, and highest). To evaluate associations between body composition and mortality, we conducted survival analyses using Cox proportional hazards model (ref. lowest group).ResultsA total of 1575 patients were included in the analysis (mean age, 78.2 years; 63.2% women). The highest FMI and %FM groups had a lower risk of mortality than that in the lowest group (hazard ratio [95% confidence interval]: FMI, 0.55 [0.37-0.81]; %FM, 0.49 [0.33-0.71]), and this association was significant in women with MCI and AD. No significant associations were observed between MMI, FFMI, and mortality.ConclusionsLower FM may be a potential risk factor for poor prognosis, emphasizing the need to monitor it from an early stage of cognitive decline.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1182-1191"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression from mild cognitive impairment to dementia in Alzheimer's disease: Whole cortex voxelwise functional connectivity analysis with multivariate distance matrix regression.","authors":"Luiz Kobuti Ferreira, Eric Westman, Lars-Olof Wahlund, Rosaleena Mohanty","doi":"10.1177/13872877261477016","DOIUrl":"10.1177/13872877261477016","url":null,"abstract":"<p><p>BackgroundDifferentiating individuals with mild cognitive impairment who convert to dementia due to Alzheimer's disease (MCI-C) from those who do not convert (MCI-NC) is increasingly important. Functional connectivity (FC) derived from resting state functional MRI (rs-fMRI) has been investigated as a potential biomarker. However, improved data analysis strategies are needed. One underexplored approach is pairwise voxel-to-voxel analysis.ObjectiveTo describe differences in FC between amyloid positive MCI-C and MCI-NC using a whole-cortex voxel-to-voxel pairwise approach.MethodsBaseline rs-fMRI from the Alzheimer's Disease Neuroimaging Initiative was retrieved for amyloid positive MCI participants. Voxel-to-voxel, pairwise, cortical FC was computed. Multivariate distance matrix regression was used to identify voxels presenting FC patterns that were significantly different between MCI-C and MCI-NC.Results21 MCI-C and 28 MCI-NC were included. The primary analysis with voxel-level threshold at p < 0.001 combined with cluster-level p < 0.05 yielded no significant results. At voxel-level p < 0.01 and the same cluster-level threshold, three significant clusters on the right visual cortex were found. These clusters, however, were not robust to head motion, fMRI protocol and additionally clinical or biological severity.ConclusionsProgression from Alzheimer-related MCI to dementia was not significantly associated with FC in the primary analysis. However, a less stringent threshold yielded FC differences in the occipital lobe in alignment with previous studies but were not robust to methodological and biological covariates between groups. Our findings highlight the need for larger samples and careful control of covariates to identify robust FC alterations related to dementia conversion.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1384-1395"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased cerebrospinal fluid NDRG2 is associated with non-Alzheimer's disease derived mild cognitive impairment.","authors":"Qing-Ning Zhang, Wei Wu, Yong-Ming Zhou, Lan-Ke Yu, Xin-Yuan Zhang, Jia-Lin Wu, Si-Yuan Song, Zhao-Hui Yao","doi":"10.1177/13872877261477113","DOIUrl":"10.1177/13872877261477113","url":null,"abstract":"<p><p>BackgroundMild cognitive impairment (MCI) lacks clear clinical biomarkers. N-Myc downstream-regulated gene 2 (NDRG2) is predominantly localized in astrocytes and is implicated in cognitive function.ObjectiveThis study aims to explore whether cerebrospinal fluid (CSF) NDRG2 could predict MCI and investigate its underlying mechanisms of cognitive decline.MethodsA total of 650 CSF samples were collected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, comprising 157 normal individuals, 366 MCI patients, and 127 Alzheimer's disease (AD) patients. One-way analysis of covariance (ANCOVA) was employed to assess differences in CSF NDRG2 levels among groups. Linear regression was used to analyze the correlation between NDRG2 and amyloid-β (Aβ), phosphorylated tau (p-tau), ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET), albumin quotient (Qalb), and growth-associated protein 43 (GAP43). Receiver operating characteristic (ROC) curves were used to examine the diagnostic performance of NDRG2 for MCI.ResultsCSF NDRG2 levels were significantly reduced in MCI, most prominently in non-Aβ and non-tau subgroups. NDRG2 discriminated Aβ-negative MCI with an area under the curve (AUC) of 0.719, but showed limited discriminatory capacity in Aβ+, tau+, and apolipoprotein E ε4 (<i>APOE</i> ε4) carrier groups. Furthermore, CSF NDRG2 levels were positively correlated with GAP-43, a marker of synaptic plasticity.ConclusionsThe present study demonstrates that NDRG2 is a potential biomarker for non-AD derived MCI and suggests its involvement in synaptic plasticity impairment.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1420-1439"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms and low cognitive performance in Chinese older adults: A severity-graded epidemiological analysis and a BARNN-inspired prospective risk-prediction framework with strict participant-level temporal validation.","authors":"Qiang Zhang, Xiao Cai, Yifan Zhao, Xinsong Ren, Dongwei Yan","doi":"10.1177/13872877261482053","DOIUrl":"10.1177/13872877261482053","url":null,"abstract":"<p><p>BackgroundLate-life depression is robustly associated with subsequent cognitive impairment, yet the dose-response gradient and temporally validated, uncertainty-aware prediction tools remain understudied in Chinese older adults.ObjectiveTo characterize the severity-graded epidemiological association between depressive symptoms and low cognitive performance, and to develop and validate a prospective risk-prediction framework with explicit uncertainty estimation.MethodsWe analyzed 31,570 observations from 12,494 participants aged ≥45 years in the China Health and Retirement Longitudinal Study (2011-2020). Depressive symptoms were measured with the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10); low cognitive performance was defined as total cognition score < 10. Layer 1 reported severity-graded prevalence and adjusted odds ratios. Layer 2 implemented a BARNN-inspired prospective state-transition predictor via a diverse tree ensemble, yielding predictive probability and epistemic uncertainty. Both layers used strict participant-level temporal validation.ResultsClinically significant depressive symptoms (CESD-10 ≥ 10) were associated with twofold higher odds of low cognitive performance (OR = 2.07, 95% CI 1.97-2.18), with a monotonic dose-response gradient across severity tiers (20.8% to 46.0%, p < 0.001). In prospective validation, the ensemble achieved comparable discrimination (AUC-ROC 0.838 versus 0.839 for logistic regression, P = 0.85) but superior calibration (Brier score 0.099 versus 0.126), plus per-sample uncertainty estimates and an explicit algorithmic deferral tier. The frozen four-tier rule produced a steep risk gradient (Low 5.8%, Moderate 24.9%, High 63.0%; OR high versus low=27.8).ConclusionsDepressive symptom severity shows a robust graded association with low cognitive performance in Chinese older adults. The framework supports reliable ordinal risk stratification with algorithmic deferral, providing a transferable template for population-level cognitive monitoring.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1797-1809"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-life candidate vascular plasma biomarkers are associated with MRI markers of vascular brain injury and amyloid- and tau-PET in cognitively healthy adults.","authors":"Martin D Mulligan, Ruiqi Wang, Qiong Yang, Alexa S Beiser, Pauline Maillard, Claudia Satizabal, Saptaparni Ghosh, Jeremy Tanner, Keith A Johnson, Charles DeCarli, Russell P Tracy, Daniel Levy, Emelia J Benjamin, Georges El Fakhri, Ramachandran S Vasan, Sudha Seshadri, Emer R McGrath","doi":"10.1177/13872877261480733","DOIUrl":"10.1177/13872877261480733","url":null,"abstract":"<p><p>BackgroundIdentifying candidate biomarkers for preclinical dementia could improve our understanding of underlying biological pathways leading to vascular brain injury (VBI) and neurodegeneration.ObjectiveTo identify plasma protein markers of MRI markers of VBI and amyloid- and tau-PET burden in cognitively healthy adults.Methods125 plasma proteins were measured in dementia-free Framingham third Generation cohort participants between 2002-2005 (mean age 46 [SD 8]) with available MRI brain (n = 1039), ¹¹C-Pittsburgh Compound-B (PiB)- (n = 279), and/or ¹⁸F-Flortaucipir (FTP)-PET (n = 239) performed ∼13-15 years after blood sampling. Outcomes included white matter hyperintensities, peak width of skeletonized mean diffusivity, and free water); precuneus-, posterior cingulate- and frontal, lateral and retrosplenial cortices-Aβ deposition; and global- and entorhinal cortex-tau.ResultsGrowth differentiation factor-15 (GDF-15) was associated with increased VBI (p ≤ 0.02), while soluble receptor for advanced glycation end products (sRAGE) and insulin-like growth factor 1 (IGF-1) were associated with reduced VBI (p ≤ 0.04). Plasma tau, renin, and ApoB were associated with increased Aβ deposition (p ≤ 0.02), while sRAGE was associated with reduced Aβ deposition in all regions (p ≤ 0.03). Brain natriuretic peptide (NT-proBNP) and purine nucleoside phosphorylase (PNP) were associated with increased tau deposition (p ≤ 0.02), while low density lipoprotein cholesterol (LDL-C) and GDF-15 were associated with reduced tau deposition (p ≤ 0.04).ConclusionsCandidate vascular plasma proteins measured in dementia-free, asymptomatic adults at late mid-life were associated with subsequent neuroimaging markers of VBI and tau and amyloid deposition. Our findings highlight potential novel candidate vascular biomarkers for preclinical dementia but will require validation.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1674-1699"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis between complement proteins and Alzheimer's disease.","authors":"Ying-Tong Lu, Zi-Ming Guo, Meng-Yuan Liu, Cheng-Hong Ji, Yu-Ting Luo, Shu-Yun Zhou, Tao Ma, Xi-Chen Zhu","doi":"10.1177/13872877261475358","DOIUrl":"10.1177/13872877261475358","url":null,"abstract":"<p><p>BackgroundThe prominent pathological features of Alzheimer's disease (AD) are amyloid-β (Aβ) plaques and tau pathology. The complement cascade is closely related to AD-associated pathological processes; however, the precise mechanisms underlying its contributions remain incompletely elucidated.ObjectiveWe aim to investigate the changes in complement protein expression during AD progression.MethodsThis study enrolled 285 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Participants were classified into biomarker-defined groups based on predefined cutoff values for Aβ₄₂ and phosphorylated tau (P-tau). We compared cerebrospinal fluid (CSF) levels of complement proteins (C1q, C2, C3, C4a, C5, C6, C8b, and factor B) across these subgroups. Furthermore, we explored their associations with core AD biomarkers (Aβ₄₂, P-tau, and T-tau) and clinical characteristics. Additionally, we investigated age-related changes in complement gene expression within the cerebral cortex of 3xTg mice using single-nucleus RNA sequencing.ResultsComplement protein levels in the CSF of A + subjects were significantly lower than those in A- subjects, and complement protein levels were positively correlated with Aβ pathology. Complement protein levels were influenced by factors such as age, gender, body mass index, <i>APOE</i> genotype, and hypertension. Compared with control mice, the complement gene C1qa in microglia was upregulated throughout the entire pathological cycle in 3xTg AD mice.ConclusionsComplement proteins undergo significant changes during the pathogenesis of AD, and alterations in their levels may reflect early pathological changes in AD and warrant further investigation. Notably, our findings suggest that microglia may contribute to complement-mediated pathological processes associated with AD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1119-1136"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual eligibility and neuropsychiatric symptoms and treatment disparities among Medicare Part D beneficiaries with Alzheimer's disease and related dementias.","authors":"Sara Alsharayri, Sara Knox, Maxwell Cutty, Abe Mollalo","doi":"10.1177/13872877261478140","DOIUrl":"10.1177/13872877261478140","url":null,"abstract":"<p><p>BackgroundNeuropsychiatric symptoms (NPS) are common and clinically consequential in Alzheimer's disease and related dementias (ADRD), yet their recognition and treatment may vary across socioeconomic groups. Dual-eligible Medicare-Medicaid beneficiaries represent a vulnerable population, but differences in NPS documentation and management remain unclear.ObjectiveTo examine whether dual eligibility is associated with differences in (1) documented NPS and (2) prescription fills among Medicare beneficiaries with ADRD who received home health (HH) care.MethodsWe conducted a cross-sectional study of 167,484 Medicare Part D beneficiaries with ADRD who received HH care and were identified using the Chronic Conditions Warehouse flag. Dual eligibility was the primary exposure. NPS were identified using diagnosis codes from medical claims. Prescription fills for NPS-related medications were identified using Medicare Part D prescription drug event data (≥2 prescription fills for anxiety-related medications and antidepressants). Logistic regression models estimated associations of dual eligibility with NPS documentation and prescription fills, adjusting for demographic characteristics, original Medicare entitlement, and comorbidity burden.ResultsDual-eligible beneficiaries comprised 30.7% of the cohort. Documented confusion and anxiety were the most prevalent symptoms. Dual-eligible beneficiaries had a higher prevalence of confusion (83.5% versus 82.0%) and anxiety (57.0% versus 53.2%) compared with Medicare-only beneficiaries. After adjustment, dual eligibility was associated with higher odds of documented confusion (aOR 1.18, 95% CI 1.14-1.22) and anxiety (aOR 1.19, 95% CI 1.15-1.22). Dual eligibility was also associated with slightly higher odds of anxiety-related prescription fills (aOR 1.21, 95% CI 1.17-1.26), whereas antidepressant prescription fills did not differ (aOR 1.00, 95% CI 0.95-1.05).ConclusionsDual eligibility was associated with modest differences in NPS documentation and prescription fills, suggesting differences in recognition and management of NPS among beneficiaries with ADRD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1449-1457"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bazedoxifene restores myelin changes and attenuates cognitive deficits in a mouse model of Alzheimer's disease.","authors":"Man-Yu Xu, Yu-Di Bai, Xiao-Qin Zeng, Cheng-Rong Tan, Yu-Jie Lai, Yan-Jiang Wang","doi":"10.1177/13872877261490479","DOIUrl":"https://doi.org/10.1177/13872877261490479","url":null,"abstract":"<p><p>BackgroundDemyelination and remyelination are critical processes in the pathogenesis of Alzheimer's disease (AD). The selective estrogen receptor modulator bazedoxifene (BZA) has been shown to promote remyelination, suggesting its potential therapeutic efficacy.ObjectiveThis study aimed to evaluate the therapeutic efficacy of BZA in addressing demyelination and associated cognitive deficits in a mouse model of AD.MethodsThe changes in myelin and oligodendrocyte-related indicators in the brains of APP/PS1 mice were assessed via immunostaining. 5 × FAD transgenic mice received oral administration of BZA or vehicle for 3 months. The therapeutic outcomes were evaluated through behavioral tests, immunostaining and western blotting.ResultsAD mice exhibited pronounced myelin loss and oligodendrocytes depletion. BZA treatment attenuated cognitive decline, restored myelin changes and mitigated neurodegeneration in the brain. These effects were observed independently of alterations in amyloid-β deposition.ConclusionsThese findings provide compelling evidence supporting the involvement of demyelination in AD and suggest that BZA may represent a promising therapeutic agent for AD by targeting myelin repair mechanisms.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877261490479"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explainable 3D deep learning from full-head MRI suggests scalp and skull involvement in Alzheimer's disease.","authors":"Mona Ebadi Jalal, Ramin Hamidi, Bryan Harris, Adel Elmaghraby, Robert P Friedland","doi":"10.1177/13872877261478312","DOIUrl":"10.1177/13872877261478312","url":null,"abstract":"<p><p>BackgroundEmerging evidence suggests that extracranial tissues and immune-glymphatic interactions may contribute to neurodegenerative processes in Alzheimer's disease (AD). In this context, neuroimaging studies typically focus on intracranial brain structures, often excluding extracranial structures and adjacent meningeal regions through preprocessing steps.ObjectiveTo investigate whether full-head MRI contains potentially relevant information beyond the brain and whether explainable deep learning can identify spatial patterns associated with AD, mild cognitive impairment (MCI), and cognitively normal (CN) subjects.MethodsAn explainable full-head 3D deep learning framework based on DenseNet-121 with transfer learning from MedicalNet was proposed and applied to T1 MP-RAGE MRI data from the ADNI dataset. The model was trained on full-head MRI volumes without skull stripping using subject-level splits and evaluated across clinically relevant classification scenarios. Grad-CAM was used to localize regions contributing to model predictions.ResultsIn the three-class task (AD, CN, MCI), the model achieved 75.00% accuracy and 86.09% ROC-AUC. Performance was highest for distinguishing AD from CN (91.07% accuracy, 95.16% ROC-AUC) and remained strong for the combined (AD + MCI) versus CN (85.58% accuracy, 96.17% ROC-AUC). Explainability analysis revealed consistent saliency patterns not only within intracranial regions but also in peripheral regions, which may correspond to extracranial structures, such as scalp and skull.ConclusionsFull-head MRI may contain complementary, potentially diagnostically relevant information beyond the brain. Peripheral saliency patterns identified by our framework suggest a broader anatomical context for signals associated with AD. These findings are hypothesis-generating and require further validation across independent datasets and clinical studies, motivating targeted investigation.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1478-1492"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of previous parity in the relationship between lifetime physical activity and later life cognition: The Rancho Bernardo study.","authors":"Vanja Petrović, Emilie T Reas, Raylene A Reimer, Cindy K Barha","doi":"10.1177/13872877261477010","DOIUrl":"10.1177/13872877261477010","url":null,"abstract":"<p><p>BackgroundParity history influences dementia risk and cognitive aging, and recent evidence suggests it may also influence the association between physical activity and cognition in later life.ObjectiveTo examine associations between total lifetime and life-stage-specific physical activity and later life cognition in postmenopausal females with differing parity histories.MethodsThis cross-sectional analysis using data from the Rancho Bernardo Study included 867 postmenopausal females with complete data, categorized into three parity groups (number of pregnancies >6-months): nulliparous, 1-2 pregnancies, and grand-multiparous (≥3 pregnancies). Cognitive outcomes included executive functions and memory. Physical activity was assessed using a self-report questionnaire capturing retrospective activity during adolescence, age 30, age 50, and current activity in later life. Covariates included age, education, health composite score, body mass index, and hysterectomy status. Linear models examined associations between physical activity and domain-specific later life cognitive outcomes stratified by parity.ResultsGreater total lifetime physical activity was associated with higher executive functions in nulliparous and grand-multiparous females. Moderate activity in nulliparous females and high activity in grand-multiparous females during adolescence and at age 30 were associated with higher executive functions. High physical activity at age 50 and currently was associated with higher executive functions in nulliparous females.ConclusionsThe findings suggest the relationship between self-reported physical activity and cognition was strongest in the two groups at greater risk for cognitive decline and Alzheimer's disease, the nulliparous and grand-multiparous groups. Further research is needed to understand the mechanisms driving parity differences.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"1370-1383"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}