Journal of Alzheimer's Disease最新文献_第10页

Virtual group singing programs for well-being in healthy older adults and persons with neurocognitive disorders during early COVID-19 pandemic: A perspective from Chicago. 在COVID-19大流行早期，为健康老年人和神经认知障碍患者提供幸福的虚拟团体歌唱项目：来自芝加哥的视角。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251333155

Borna Bonakdarpour, Rhiana Schafer, Clara Takarabe, Elena Barbieri, Jonathan Miller, Sandra Siegel Miller

{"title":"Virtual group singing programs for well-being in healthy older adults and persons with neurocognitive disorders during early COVID-19 pandemic: A perspective from Chicago.","authors":"Borna Bonakdarpour, Rhiana Schafer, Clara Takarabe, Elena Barbieri, Jonathan Miller, Sandra Siegel Miller","doi":"10.1177/13872877251333155","DOIUrl":"https://doi.org/10.1177/13872877251333155","url":null,"abstract":"BackgroundDuring the COVID-19 pandemic, older adults experienced health declines due to isolation. Group singing is known to enhance social, emotional, and physical well-being, but its feasibility in virtual formats was unclear.ObjectiveTo assess the feasibility of virtual group singing for cognitively healthy (CH) adults and individuals with neurocognitive disorders (NcD) during the pandemic.MethodTwo teleconferencing programs were conducted for participants aged >55: (1) a sing-along series with 52 weekly sessions of familiar music and (2) a choir program with structured weekly rehearsals culminating in a virtual concert. Retrospective surveys assessed anxiety reduction, social connection, and physical well-being using Likert scales and participants provided open-ended responses. Quantitative data were analyzed with ordinal regression and probability modeling, while qualitative themes were explored with Fisher's exact test.ResultsParticipants reported high levels of satisfaction across all measures. Sing-along programs provided greater satisfaction, particularly through reminiscence (p = 0.003). Choir participants noted enhanced intellectual well-being (p = 0.017). NcD participants were less satisfied with social connection but showed similar overall satisfaction levels compared to CH participants.ConclusionsVirtual group singing was feasible during periods of isolation as supported by satisfaction of the participants with pertaining to anxiety reduction, social connection and physical well-being. Sing-along programs provided emotional satisfaction through reminiscence (connection to past), while choir programs offered intellectual stimulation through multiple rehearsals. These findings highlight the potential of virtual singing to promote stability, connection, and well-being for older adults during times of disruption.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251333155"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild cognitive impairment, Alzheimer's disease dementia, and predictors of driving cessation: A 7-year longitudinal prospective study. 轻度认知障碍、阿尔茨海默病痴呆和停止驾驶的预测因素：一项7年纵向前瞻性研究。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251333705

Petros Stamatelos, Ion N Beratis, Panagiota Hatzaki, Alexandra Economou, Nikolaos Andronas, Dimosthenis Pavlou, Styliani P Fragkiadaki, Dionysia Kontaxopoulou, Anastasios Bonakis, Leonidas Stefanis, George Yannis, Sokratis G Papageorgiou

{"title":"Mild cognitive impairment, Alzheimer's disease dementia, and predictors of driving cessation: A 7-year longitudinal prospective study.","authors":"Petros Stamatelos, Ion N Beratis, Panagiota Hatzaki, Alexandra Economou, Nikolaos Andronas, Dimosthenis Pavlou, Styliani P Fragkiadaki, Dionysia Kontaxopoulou, Anastasios Bonakis, Leonidas Stefanis, George Yannis, Sokratis G Papageorgiou","doi":"10.1177/13872877251333705","DOIUrl":"https://doi.org/10.1177/13872877251333705","url":null,"abstract":"BackgroundPatients with dementia face driving difficulties and, at some point, cease driving.ObjectiveWe sought to identify predictors of driving cessation among patients with mild cognitive impairment (MCI) or mild Alzheimer's disease dementia (AD).MethodsWe enrolled in this longitudinal study patients with MCI, AD (Clinical Dementia Rating < 2) and cognitively normal (NC) individuals. At baseline evaluation, participants underwent a neurological, neuropsychological and driving simulator assessment. Re-evaluations after 48 and 84 months included a structured interview with the patients and their caregiver. Primary endpoints were driving cessation, death and progression to dementia.Results109 individuals were included (32 NC, mean age 65.8 years/47 MCI, mean age 69.1 years/30 AD, mean age 72.8 years). Dangerous driving events during follow-up were referred for 45% and 59% of MCI and AD patients, respectively. 18 MCI (38%, mean time to cease 35 months) and 25 AD (83%, mean time to cease 15 months) patients ceased driving during follow-up. 36% of MCI patients progressed to dementia during follow-up. Cox Regression multivariate analysis revealed age (Hazard Ratio-HR 1.080), semantic verbal fluency-SVF (HR 0.822) and Tandem Walking Test modified with simultaneous reverse number counting-mTWT (HR 1.099) as significant predictors of driving cessation. Simulator accident probability reached statistical significance only in the univariate model (HR 1.040).ConclusionsAge, SVF and mTWT are significant predictors of driving cessation among MCI and AD patients. Driving simulator may be a promising component of driving evaluation. Large-scale studies are prerequisite for the implementation of a multi-disciplinary driving fitness evaluation protocol.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251333705"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and attitudes about dementia and dementia genetics in a cohort of geriatric clinic attendees in Nigeria. 尼日利亚一群老年临床参会者对痴呆和痴呆遗传学的知识和态度。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251333816

David Oluwasayo Babalola, Boluwatife Adeleye Adewale, Kenechukwu Franklin Okwunze, Teslim Timilehin Mohammed, Ifeoluwa Oluwasegun Oduguwa, Hilda Amauche Igwe, Temitope Farombi, Rufus Olusola Akinyemi

{"title":"Knowledge and attitudes about dementia and dementia genetics in a cohort of geriatric clinic attendees in Nigeria.","authors":"David Oluwasayo Babalola, Boluwatife Adeleye Adewale, Kenechukwu Franklin Okwunze, Teslim Timilehin Mohammed, Ifeoluwa Oluwasegun Oduguwa, Hilda Amauche Igwe, Temitope Farombi, Rufus Olusola Akinyemi","doi":"10.1177/13872877251333816","DOIUrl":"https://doi.org/10.1177/13872877251333816","url":null,"abstract":"BackgroundPopulation ageing in Africa will increase the burden of Alzheimer's disease and related dementias within the next few decades. Despite the potential for discovery of novel genetic risks in African populations, there is still a paucity of dementia genetic research among indigenous Africans.ObjectiveWe aimed to investigate the knowledge and attitudes of elderly population in Nigeria about dementia and dementia genetics.MethodsOne hundred clinic attendees (aged ≥60 years) recruited at the University College Hospital, Ibadan, Nigeria were surveyed using an interviewer-administered questionnaire consisting of the Dementia Knowledge Assessment Scale (DKAS) and other items assessing knowledge and attitudes about dementia genetics.ResultsThe mean age (±SD) of participants was 71.0 (±7.1) years, and the mean (±SD) DKAS score was 8.87 (±10.84). Only 10% were considered to have good knowledge of dementia (i.e., DKAS score ≥26). Attempts by participants to translate \"dementia\" in their local languages revealed misleading themes in their perception of the condition. Of the 42 participants who claimed to know what dementia is, 32 (76.2%) of them had poor knowledge (i.e., DKAS <26). Twenty-one participants were aware of the existence of genetic risk factors for dementia, but none could name a dementia risk gene. Seventy participants expressed willingness to undergo genetic testing to assess their risk of dementia.ConclusionsThere is a poor level of knowledge about dementia and dementia genetics among the elderly population in Nigeria. Public health education and community engagement is important for maximizing the impact of dementia genetic studies in Africa.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251333816"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance on the Rey-Osterrieth complex figure test in non-demented middle-aged and elderly Koreans. 非痴呆中老年韩国人在Rey-Osterrieth复杂形体测试中的表现。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251332663

Hyejin Ahn, Woo-Jin Cha, Do Hyeon Woo, Seunghyuk Ha, Kyungtae Kim, Hyeji Choi, Min Soo Byun, Gijung Jung, Dahyun Yi, Dong Young Lee

{"title":"Performance on the Rey-Osterrieth complex figure test in non-demented middle-aged and elderly Koreans.","authors":"Hyejin Ahn, Woo-Jin Cha, Do Hyeon Woo, Seunghyuk Ha, Kyungtae Kim, Hyeji Choi, Min Soo Byun, Gijung Jung, Dahyun Yi, Dong Young Lee","doi":"10.1177/13872877251332663","DOIUrl":"https://doi.org/10.1177/13872877251332663","url":null,"abstract":"BackgroundExisting studies on Rey-Osterrieth Complex Figure (ROCF) performance in South Korea have not fully accounted for key demographic factors and often include limited sample sizes. This study examines ROCF performance in a non-demented aging sample to explore cognitive variability and provide comparative data for future research.ObjectiveThis study investigates the effects of age, education, and gender on performance on the ROCF test copy, immediate recall, and delayed recall trials for middle-aged and elderly Koreans.MethodsThe ROCF was administered to 461 community-dwelling, non-demented adults aged 50 to 90 years (M = 70.1, SD = 8.4), with 0 to 25 years of education (M = 11.4, SD = 4.7). We analyzed cognitive performance across age groups (50-59, 60-69, 70-79, and 80-90 years), education levels (0-8, 9-12, ≥13 years), and gender to characterize cognitive variability in a non-demented aging sample. Analysis of variance and stepwise multiple regression analyses were conducted to assess the relative contributions of the demographic variables.ResultsLower education levels, advanced age, and female gender were associated with poorer performance. Education accounted for the greatest variation in the copy trials, whereas age accounted for the largest portion of the variance in the recall trials.ConclusionsThe findings highlight the necessity of accounting for age, education, and gender when interpreting ROCF test scores in aging populations, especially in South Korea where educational attainment among older adults varies widely. Based on these findings, we established reference values stratified by these demographic variables for middle-aged and older Korean adults.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251332663"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resilient together for dementia: A qualitative study of couples' treatment preferences to address distress early after diagnosis. 弹性一起痴呆：夫妇的治疗偏好的定性研究，以解决早期诊断后的困扰。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251332658

Sarah M Bannon, Sydney McCage, Kristin Walker, Julie Brewer, Nina Ahmad, Talea Cornelius, Robert A Parker, Kristen Dams-O'Connor, Bradford Dickerson, Christine S Ritchie, Ana-Maria Vranceanu

{"title":"Resilient together for dementia: A qualitative study of couples' treatment preferences to address distress early after diagnosis.","authors":"Sarah M Bannon, Sydney McCage, Kristin Walker, Julie Brewer, Nina Ahmad, Talea Cornelius, Robert A Parker, Kristen Dams-O'Connor, Bradford Dickerson, Christine S Ritchie, Ana-Maria Vranceanu","doi":"10.1177/13872877251332658","DOIUrl":"https://doi.org/10.1177/13872877251332658","url":null,"abstract":"BackgroundDespite technological advances and earlier and more confident diagnoses, there is a lack of post-diagnosis support for couples navigating the challenges of early dementia. Clinically elevated emotional distress is common for both partners after diagnosis, and interferes with the health, relationships, and adjustment of both partners if not addressed.ObjectiveOur objective was to gather in-depth information on couples' preferences to inform the development of a proposed dyadic intervention addressing emotional distress early (within 6 months) after one partners' receipt of a dementia diagnosis.MethodsWe recruited couples after a recent dementia diagnosis (N = 16 dyads; 32 participants) from a large academic medical center via direct provider referrals for 60-min virtual dyadic interviews. Data were analyzed using a hybrid inductive-deductive approach to thematic analysis.ResultsWe identified themes within 3 a-priori determined domains. For dyadic intervention format (domain 1), couples preferred to participate in sessions together and to have flexible options for telehealth and in-person participation. Preferences for intervention content (domain 2) included information on dementia, skills to reduce distress and promote resiliency, and support to communicate about the diagnosis and related stress. Barriers and facilitators (domain 3) included denial or hesitation, resource constraints, and interests in learning skills and connecting to others.ConclusionsWe gathered comprehensive information that could be used to adapt existing dyadic interventions and to tailor support to match couples' preferences early after dementia diagnoses. Early interventions should prioritize flexible delivery of information and skills to couples to support adaptive coping following dementia diagnoses.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251332658"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns and trends in the burden of Alzheimer's disease and related dementias in China (1990-2021) and predictions to 2040. 中国阿尔茨海默病和相关痴呆负担的模式和趋势（1990-2021年）以及到2040年的预测

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251333108

Hui Min Chen, Kuo Shen, Ling Ji, Colman McGrath, Hui Chen

{"title":"Patterns and trends in the burden of Alzheimer's disease and related dementias in China (1990-2021) and predictions to 2040.","authors":"Hui Min Chen, Kuo Shen, Ling Ji, Colman McGrath, Hui Chen","doi":"10.1177/13872877251333108","DOIUrl":"https://doi.org/10.1177/13872877251333108","url":null,"abstract":"BackgroundThe epidemiology of Alzheimer's disease and related dementias (ADRD) in China is understudied as compared to global levels.ObjectiveThe aim of this study was to examine the trend of dementia epidemiology in China from 1990 to 2021 and provide predictions for the next two decades.MethodsThe Global Burden of Disease study (GBD) 2021 were used to analyze the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) rates due to ADRD in China and globally. Joinpoint regression analysis was used to analyze the epidemiological trends from 1990 to 2021. A forecast of ADRD prevalence trends was conducted utilizing Autoregressive Integrated Moving Average (ARIMA) models.ResultsChina was experiencing a growing burden of ADRD. As of 2021, the number of people with dementia in China had risen to 56.85 million (95%CI: 49.38, 64.98), up from 21.80 (95%CI: 19.07, 24.84) million in 1990. The prevalence, incidence, mortality, and DALY rates all indicated a greater disease burden among the Chinese population compared to global levels, with a significantly higher burden in the female group. The projected prevalence rate was expected to increase by 60% compared to the current prevalence rate.ConclusionsAs the population in China continues to age, ADRD presents an undeniable challenge. To mitigate the growing burden of ADRD and improve the overall health of the population, it is essential to establish a comprehensive plan that focuses on increasing public awareness and enhancing the quality of life for all, with special attention given to women.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251333108"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of obesity on neuropsychiatric symptoms in Alzheimer's disease: Insights from the ADNI cohort. 肥胖对阿尔茨海默病神经精神症状的影响：来自ADNI队列的见解

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251331974

Shuoshi Wang, Jingnian Ni, Mingqing Wei, Ting Li, Jing Shi, Jinzhou Tian

{"title":"Impact of obesity on neuropsychiatric symptoms in Alzheimer's disease: Insights from the ADNI cohort.","authors":"Shuoshi Wang, Jingnian Ni, Mingqing Wei, Ting Li, Jing Shi, Jinzhou Tian","doi":"10.1177/13872877251331974","DOIUrl":"https://doi.org/10.1177/13872877251331974","url":null,"abstract":"BackgroundObesity is a major global health issue linked to increased risks of dementia, including Alzheimer's disease (AD). While the association between obesity and neuropsychiatric symptoms (NPS) in AD remains underexplored, identifying these links could aid in weight management in AD patients.ObjectiveThis study investigates the relationship between body mass index (BMI) and NPS in AD dementia patients, focusing on the potential mediating role of systemic inflammation.MethodsWe employed Generalized Additive Models (GAMs) to explore the relationship between BMI and NPS, as measured by the Neuropsychiatric Inventory Questionnaire (NPI-Q). Participants were classified into ideal, overweight, and obese groups based on WHO criteria. Longitudinal analyses assessed the trajectory of NPI-Q scores in different groups over a one-year follow-up.ResultsBMI significantly affects NPI-Q total scores and specific symptoms, including delusions, hallucinations, agitation/aggression, elation/euphoria, disinhibition, irritability/lability, aberrant motor behavior, nighttime disturbances, and appetite/eating disturbances. Obese patients exhibited higher NPI-Q total scores and greater severity in symptoms such as hallucinations, agitation/aggression, elation/euphoria, apathy/indifference, disinhibition, aberrant motor behavior, and nighttime disturbances. Additionally, CRP and complement C3 were identified as mediators in the relationship between obesity and NPS, highlighting the role of systemic inflammation.ConclusionsThis study demonstrates that obesity is associated with a heightened burden of NPS in AD dementia patients. The identification of CRP and complement C3 as mediators suggests inflammation plays a crucial role in the association between obesity and NPS. These findings underscore the importance of addressing obesity and its inflammatory consequences in managing NPS among this vulnerable population.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251331974"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision neurocognition: An emerging diagnostic paradigm leveraging digital cognitive assessment technology. 精确神经认知：利用数字认知评估技术的新兴诊断范式。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251325725

David J Libon, Rodney Swenson, Dianne Teresa Langford, Stephanie Cosentino, Catherine C Price, Melissa Lamar, Sheina Emrani, Rhoda Au, Stacy Andersen, Michelle H Chen, Lee Ashendorf, Louisa Thompson

{"title":"Precision neurocognition: An emerging diagnostic paradigm leveraging digital cognitive assessment technology.","authors":"David J Libon, Rodney Swenson, Dianne Teresa Langford, Stephanie Cosentino, Catherine C Price, Melissa Lamar, Sheina Emrani, Rhoda Au, Stacy Andersen, Michelle H Chen, Lee Ashendorf, Louisa Thompson","doi":"10.1177/13872877251325725","DOIUrl":"https://doi.org/10.1177/13872877251325725","url":null,"abstract":"Strategies that may modify Alzheimer's disease (AD) and other dementia disorders are being developed. To maximize the benefits of these strategies, it is critical that indicators suggesting neurocognitive decline are identified as early as possible. 'Precision neurocognition' is a heuristic that seeks to develop methodologies capable of identifying subtle behavior(s) that may flag emerging AD and other dementia related syndromes. Recent research suggests that digital neuropsychological assessment technology may be the platform that can realize the goals of precision neurocognition, i.e., the early detection of neurocognitive difficulties that are prognostic for mild cognitive impairment (MCI) and dementia. Past research associating 100% correct or statistically within normal limits responding using neuropsychological tests with time-based parameters obtained while participants undergo assessment is reviewed. Recent research with community dwelling and memory clinic participants examined test scores obtained using commonly available neuropsychological tests. This research extracted a number of discrete latency measures that clearly dissociate between groups, despite final test scores that are either 100% correct or statistically within normal limits. In sum, past research using digitally administered neuropsychological tests suggests that the goals of precision neurocognition as related to the early identification of neurodegenerative illness may be realized via an analysis of time derived, process-based behavior using digital assessment technology. Latency or time-based parameters as described in recent research could form the basis of a range of neurocognitive biomarkers for identifying people at risk for developing AD, other dementing disorders, and MCI.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251325725"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of C-reactive protein and interleukin-3 on mild cognitive impairment with APOE ɛ4. c -反应蛋白和白介素-3对轻度认知障碍apoe4的影响。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251333149

Xinyi Yang, Lei Chi, Meizhao Qiao, Anxing Huang, Huimin Wu, Shanshan Chen, Jia Fan, Xingjian Lin, Jiu Chen

{"title":"The effect of C-reactive protein and interleukin-3 on mild cognitive impairment with APOE ɛ4.","authors":"Xinyi Yang, Lei Chi, Meizhao Qiao, Anxing Huang, Huimin Wu, Shanshan Chen, Jia Fan, Xingjian Lin, Jiu Chen","doi":"10.1177/13872877251333149","DOIUrl":"https://doi.org/10.1177/13872877251333149","url":null,"abstract":"BackgroundThe apolipoprotein E ε4 allele (APOE ε4) and inflammation are associated with Alzheimer's disease (AD) pathology. Mild cognitive impairment (MCI) is considered the preclinical and early stage of AD. However, the comprehensive effects of APOE ε4 and inflammatory mediators on MCI patients with specific APOE ε4 genotypes remain poorly understood.ObjectiveOur study aimed to explore how different numbers of the APOE ε4 alleles affect plasma C-reactive protein (CRP) and interleukin-3 (IL-3) levels and their associations with brain structure.MethodsA total of 339 MCI patients from the Alzheimer's Disease Neuroimaging Initiative study were enrolled. We compared their plasma concentrations of CRP and IL-3, cognitive performance, and cerebrospinal fluid (CSF) AD biomarkers levels across different APOE ε4 genotypes. Structural magnetic resonance imaging was utilized to measure gray matter volume outcomes. Pearson correlation analysis was used to explore the associations between the above indicators.ResultsPlasma CRP levels increased in the APOE ε4 carriers, but IL-3 expression notably decreased, and the homozygous state is the most significant. A negative correlation between CRP and several cognitive abilities was observed only in APOE ε4 homozygotes. Additionally, a positive correlation between IL-3, cognitive scores, and CSF biomarker levels was confirmed only in APOE ε4 homozygotes. Imaging data demonstrated that the gray matter volume of the right middle frontal gyrus was associated with CRP only in APOE ε4 non-carriers.ConclusionsOur study demonstrated that peripheral inflammatory mediators' effect on cognitive function and brain structure in MCI patients differs based on their APOE ε4 allele carrier status.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251333149"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal deterioration of subjective cognitive decline in apolipoprotein ε4 carriers and improvement of subjective cognitive decline by multi-domain intervention for prevention of dementia: The cognitive function instrument assessment. 载脂蛋白ε4携带者主观认知能力下降的纵向恶化及多领域干预预防痴呆对主观认知能力下降的改善：认知功能仪器评估

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-04-22 DOI: 10.1177/13872877251332647

Tohmi Osaki, Yutaro Oki, Ryoko Kumagai, Rei Ono, Hisafumi Yasuda, Yoji Nagai, Hisatomo Kowa

{"title":"Longitudinal deterioration of subjective cognitive decline in apolipoprotein ε4 carriers and improvement of subjective cognitive decline by multi-domain intervention for prevention of dementia: The cognitive function instrument assessment.","authors":"Tohmi Osaki, Yutaro Oki, Ryoko Kumagai, Rei Ono, Hisafumi Yasuda, Yoji Nagai, Hisatomo Kowa","doi":"10.1177/13872877251332647","DOIUrl":"https://doi.org/10.1177/13872877251332647","url":null,"abstract":"BackgroundSubjective cognitive decline represents an early stage of mild cognitive impairment, with the Cognitive Function Instrument (CFI) serving to subjectively evaluate the decline in daily living activities associated with this minor cognitive decline.ObjectiveTo examine how CFI scores change with apolipoprotein E ε4 (ApoE4) carriage, objective cognitive decline, and dementia prevention intervention. We aimed to assess CFI's usefulness in the early dementia risk identification.MethodsThis study involved 196 older adults with normal cognition in a randomized controlled intervention trial. CFI was assessed every six months from baseline to 18 months, using the Alzheimer's Disease Cooperative Study-Preclinical Alzheimer Cognitive Composite (ADCS-PACC) to measure cognitive decline. We employed a mixed model for repeated measures to compare the CFI scores at 18 months in the ApoE4, ADCS-PACC, and allocation groups.ResultsCFI scores increased in ApoE4 carriers and decreased in the intervention group, with significant differences observed in the CFI score changes at 18 months between carriers and non-carriers and among the allocation groups (p = 0.002, p = 0.026, respectively). However, there was no significant difference in the CFI score change among ADCS-PACC groups (p = 0101).ConclusionsWe observed CFI scores worsening over time in individuals with ApoE4 and showing a tendency to deteriorate over time in those with objective cognitive decline. These findings suggest that the CFI may be able to identify high-risk individuals for dementia at an early stage. Furthermore, the improvement in the CFI score is considered a significant finding when considering future measures for subjective cognitive decline.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251332647"},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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