Journal of Alzheimer's Disease最新文献_第10页

To know or to not know: The importance of assessing awareness of cognitive function in the early stages of Alzheimer's disease. 知道还是不知道：评估阿尔茨海默病早期认知功能意识的重要性。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-16 DOI: 10.1177/13872877251350138

Patrizia Vannini, Giovanna Zamboni

引用次数: 0

Presence of Alzheimer's disease variants in circular RNA of PSEN1 and PSEN2. PSEN1和PSEN2环状RNA中阿尔茨海默病变体的存在。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-16 DOI: 10.1177/13872877251350112

Ian P Johnson, Tia M Peterson, Kathryn Gudsnuk, C Dirk Keene, Thomas D Bird, Suman Jayadev, Paul N Valdmanis, Meredith M Course

引用次数: 0

Vitamin D and cognition: Demographic disparities in memory recall and word intrusion in a multiethnic cohort. 维生素D与认知：多种族队列中记忆回忆和单词入侵的人口统计学差异。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-16 DOI: 10.1177/13872877251344604

Juan C Lopez-Alvarenga, Isabel Omaña-Guzmán, Oscar Rosas-Carrasco, Jose E Cavazos, Michael C Mahaney, Gladys E Maestre

{"title":"Vitamin D and cognition: Demographic disparities in memory recall and word intrusion in a multiethnic cohort.","authors":"Juan C Lopez-Alvarenga, Isabel Omaña-Guzmán, Oscar Rosas-Carrasco, Jose E Cavazos, Michael C Mahaney, Gladys E Maestre","doi":"10.1177/13872877251344604","DOIUrl":"https://doi.org/10.1177/13872877251344604","url":null,"abstract":"BackgroundVitamin D3 is essential for calcium metabolism and exerts pleiotropic effects, including neuroprotective activities in cognition. Its insufficiency has been linked to dementia, Alzheimer's disease, and cognitive impairments. The association between vitamin D3 and particular cognitive functions, including memory recall and word intrusion, remains imprecise, particularly among diverse ethnic and socioeconomic groups.ObjectiveTo examine the relationship between vitamin D3 levels with memory recall and word intrusion in individuals aged 60 and above, emphasizing demographic differences.MethodsData was collected from 2759 individuals in the NHANES 2011-2014 surveys. Cognitive performance was evaluated with the CERAD Word Learning, Animal Fluency, and Digit Symbol Substitution assessments. Factor analysis was employed to identify two cognitive domains: F1 'Memory Recall' and F2 'Word Intrusion'. Linear and quantile regression models, controlled for demographic variables, were performed to assess the association between vitamin D3 levels and cognitive domains. Bootstrap techniques were used for standard error estimation, and nonparametric regression was applied to identify non-linear correlations.ResultsVitamin D3 levels positively correlated in linear models and quantile regression with F1 'Memory Recall' at diminished cognitive function levels. F2 was not associated with vitamin D3. Socioeconomic factors influenced these correlations, revealing inequalities among ethnic and income groups.ConclusionsElevated vitamin D3 levels correlate with improved memory recall, especially in individuals with lower cognitive percentiles. These findings suggest the potential of vitamin D3 to alleviate cognitive decline, including Alzheimer's disease, highlighting the need for focused interventions, particularly in underrepresented demographic groups.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251344604"},"PeriodicalIF":3.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of comprehensive geriatric assessment intervention on serum S100β levels and clinical outcomes in patients with Alzheimer's disease. 老年综合评估干预对阿尔茨海默病患者血清S100β水平及临床结局的影响

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-10 DOI: 10.1177/13872877251344544

Da-Wei Wang, Xue-Ting Qin, Gang Wang, Juan Liu, Yu-Ping Xu, Yuan Tian, Bin Liu

{"title":"Effect of comprehensive geriatric assessment intervention on serum S100β levels and clinical outcomes in patients with Alzheimer's disease.","authors":"Da-Wei Wang, Xue-Ting Qin, Gang Wang, Juan Liu, Yu-Ping Xu, Yuan Tian, Bin Liu","doi":"10.1177/13872877251344544","DOIUrl":"https://doi.org/10.1177/13872877251344544","url":null,"abstract":"BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder that significantly impairs cognitive function, emotional health, and daily living activities. Comprehensive Geriatric Assessment (CGA) is a multidisciplinary approach designed to optimize health outcomes in older adults, but its effectiveness in managing AD remains to be fully elucidated.ObjectiveTo evaluate the impact of CGA intervention on serum S100β levels and clinical outcomes in patients with AD.MethodsIn this prospective study, 120 patients diagnosed with AD were randomly assigned to either a Control group or an Intervention group. The Control group received standard treatment and routine care, while the Intervention group received individualized care plans based on CGA in addition to standard management. Primary outcomes included serum S100β levels, Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Neuropsychiatric Inventory-Questionnaire (NPI-Q), Geriatric Depression Scale (GDS) scores, Mini-Nutritional Assessment (MNA) scores, Activities of Daily Living (ADLs), Instrumental Activities of Daily Living (IADLs), and Parkinson's Disease Questionnaire (PDQ-39) scores, assessed at baseline and during follow-up.ResultsSerum S100β levels remained stable in the Control group but significantly decreased in the Intervention group at 6 months. ADLs and IADLs scores were consistently higher in the Intervention group. Although ADAS-Cog and NPI-Q scores improved in both groups, the Intervention group demonstrated significantly lower NPI-Q scores at 6 months.ConclusionsCGA intervention effectively enhances cognitive function, emotional well-being, mobility, and social interaction in patients with AD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251344544"},"PeriodicalIF":3.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drivers with dementia: Forecasting the future. 痴呆司机：预测未来。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-04 DOI: 10.1177/13872877251344873

Mark Rapoport, Patrick A Byrne, Kim Pho, Gary Naglie

{"title":"Drivers with dementia: Forecasting the future.","authors":"Mark Rapoport, Patrick A Byrne, Kim Pho, Gary Naglie","doi":"10.1177/13872877251344873","DOIUrl":"https://doi.org/10.1177/13872877251344873","url":null,"abstract":"BackgroundA decline in driving skills is well documented in people with dementia.ObjectiveTo provide a current estimate and future forecast of drivers with dementia in Ontario, Canada, taking into account sex differences and longitudinal estimates of driving cessation in dementia.MethodsWe used historical provincial licensing data, population estimates and projections, as well as estimates of diagnosable dementia from the Landmark study of the Alzheimer's Society of Canada to create current estimates and forecasts of drivers with dementia in the province of Ontario, the most populous province of Canada, from 2024 to 2046. Sensitivity analyses were used to determine the impact of sex and assumptions regarding the rate of driving cessation.ResultsAssuming that an estimated 35% of people with diagnosable dementia stop driving very shortly after symptom onset followed by a more gradual decline over time, and that females stop driving twice as fast as men, we forecast approximately 154,000 drivers with dementia in the province of Ontario in 2046.ConclusionsAs dementia prevalence increases, our study provides a novel set of projections for drivers with dementia over the coming two decades, estimating a 221% to 226% increase. This work adds to the myriad of concerns about health and public services that will be needed to treat and support this population effectively, to detect early signs of dangerous driving among the cognitively impaired, and to provide alternative transportation options, once driving is no longer viable.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251344873"},"PeriodicalIF":3.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the directional associations of handgrip strength asymmetry and cognitive function in American males and females. 研究美国男性和女性握力不对称与认知功能的定向关联。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-04 DOI: 10.1177/13872877251346722

Ryan McGrath, Jeremy M Hamm, Bong-Jin Choi, Jagdish Singh, Donald A Jurivich, Sherri N Stastny, Chloe Carling, Jacob Kieser, Kyle J Hackney

{"title":"Examining the directional associations of handgrip strength asymmetry and cognitive function in American males and females.","authors":"Ryan McGrath, Jeremy M Hamm, Bong-Jin Choi, Jagdish Singh, Donald A Jurivich, Sherri N Stastny, Chloe Carling, Jacob Kieser, Kyle J Hackney","doi":"10.1177/13872877251346722","DOIUrl":"https://doi.org/10.1177/13872877251346722","url":null,"abstract":"BackgroundWhile low handgrip strength (HGS) and cognitive impairment could be bidirectionally associated through shared neurological systems, the role of HGS asymmetry for this directional association is not well-understood in males and females.ObjectiveThe purpose of this investigation was to determine the directional associations between HGS asymmetry and cognitive impairment in Americans by sex.MethodsThe analytical sample included 5298 male and 7070 female participants aged at least 50-years from the 2006-2018 waves of the Health and Retirement Study. HGS was measured with a handgrip dynamometer. The highest recorded HGS on both hands were included in the quantification of HGS asymmetry. Cognitive function was assessed with the Telephone Interview of Cognitive Status. Individual generalized estimating equations evaluated the directional associations of HGS asymmetry and impaired cognitive function.ResultsCategorical asymmetric HGS was associated with 1.25 (95% confidence interval (CI): 1.01-1.54) greater odds for future cognitive impairment in males. Every unit increase in continuous HGS asymmetry ratio was also associated with 1.37 (CI: 1.04-1.80) greater odds for future cognitive impairment in males. However, cognitive impairment, in males, was not significantly associated with future asymmetric HGS (odds ratio: 1.18; CI: 0.97-1.44). No significant directional associations between asymmetric HGS and impaired cognitive function were observed in females.ConclusionsAsymmetric HGS, as another marker of muscle dysfunction, may provide direction for the association between muscle and cognitive function, particularly in males. While more research is needed for examining the prognostic value of asymmetric HGS, including asymmetry is feasible in conventional HGS protocol guidelines.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251346722"},"PeriodicalIF":3.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer's disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine efficacy in aged mice. 老年小鼠阿尔茨海默病相关基因型对慢性诱发癫痫结果和抗癫痫药物疗效的影响存在差异。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-03 DOI: 10.1177/13872877251343321

Kevin M Knox, Stephanie Davidson, Leanne M Lehmann, Erica Skinner, Alexandria Lo, Suman Jayadev, Melissa Barker-Haliski

{"title":"Alzheimer's disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine efficacy in aged mice.","authors":"Kevin M Knox, Stephanie Davidson, Leanne M Lehmann, Erica Skinner, Alexandria Lo, Suman Jayadev, Melissa Barker-Haliski","doi":"10.1177/13872877251343321","DOIUrl":"10.1177/13872877251343321","url":null,"abstract":"BackgroundAlzheimer's disease (AD) patients are at greater risk of focal seizures than similarly aged adults, which may accelerate cognitive decline. Older people with epilepsy generally respond well to antiseizure medications (ASMs). However, whether specific ASMs can differentially control seizures in AD is unknown. The corneal kindled model of chronic seizures allows for precisely timed drug administration studies to expediently evaluate efficacy and tolerability of investigational treatments in AD-associated mouse models.ObjectiveWe hypothesized that mechanistically distinct ASMs would differentially control seizures of aged AD mice (9-14 months), thereby informing rational ASM selection for AD.MethodsPSEN2-N141I and APPswe/PS1dE9 mice underwent corneal kindling at 9-14 months old to quantify latency to kindled criterion versus matched wild-type mice. Dose-related response to commonly prescribed ASMs for older adults with epilepsy (valproic acid, levetiracetam, lamotrigine, phenobarbital, and gabapentin) was then assessed.ResultsSex and AD genotype differentially impacted seizure susceptibility. Male PSEN2-N141I mice required more kindling stimulations to reach criterion (χ2 = 5.521; p < 0.05). Male APP/PS1 mice were no different in kindling rate versus controls, but did have more severe seizures. There were significant ASM class-specific differences in acute seizure control and dose-related tolerability. APP/PS1 mice were more sensitive to valproic acid, levetiracetam, and gabapentin. PSEN2-N141I mice were more sensitive to valproic acid and lamotrigine.ConclusionsAD genotypes may differentially impact ASMs activity in vivo with advanced biological age. These findings highlight the heterogeneity of seizure risk in AD and suggest that precisely selected ASMs may beneficially control seizures in AD to slow cognitive decline.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251343321"},"PeriodicalIF":3.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pterosin D-activated protein kinase A mitigates Alzheimer's disease in 5xFAD mice. 翼鸟色素d活化蛋白激酶A减轻5xFAD小鼠的阿尔茨海默病。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-02 DOI: 10.1177/13872877251344627

Ha Na Kim, Won Hee Jang, Nam Sook Kang, Sungsub Kim, Kwang-Eun Choi, Anand Balupuri, Seong Su Hong, Yun-Hyeok Choi, Eun-Jae Lee, Lynkyung Choi, Jae-Young Koh, Gil Hong Park

{"title":"Pterosin D-activated protein kinase A mitigates Alzheimer's disease in 5xFAD mice.","authors":"Ha Na Kim, Won Hee Jang, Nam Sook Kang, Sungsub Kim, Kwang-Eun Choi, Anand Balupuri, Seong Su Hong, Yun-Hyeok Choi, Eun-Jae Lee, Lynkyung Choi, Jae-Young Koh, Gil Hong Park","doi":"10.1177/13872877251344627","DOIUrl":"https://doi.org/10.1177/13872877251344627","url":null,"abstract":"BackgroundProtein kinase A (PKA) is a key activator of cAMP response element-binding protein signaling; it plays a pivotal role in cognition, memory, and adult neurogenesis. Phosphodiesterase (PDE) inhibitors that indirectly activate PKA through cAMP are promising candidates for Alzheimer's disease (AD) therapeutics.ObjectiveWe examined whether pterosins bind directly to PKA as activators and enhance cognition and memory.MethodsWe investigated PKA phosphorylation and performed in silico docking analysis using the cAMP-binding domains (CBD1, CBD2) of bovine PKA. Our focus was on exploring the effects of oral pterosin D on learning and memory in a 5xFAD mouse model of AD.ResultsWe demonstrated that C3-hydroxylated pterosins directly activated PKA in neuronal cells but not in astrocytes and did not affect intracellular cAMP levels or inhibit PDE. In silico modeling implied that C3-hydroxylated pterosins fitted the CBD of PKA. Pterosins enhanced long-term potentiation mossy fiber-CA1 in the mouse hippocampus without affecting normal synaptic transmission. Pterosins more potently accelerate neuronal proliferation and neurite outgrowth in primary mouse cortical neurons than dibutyryl-cAMP does. Pterosin D significantly restored cognition and memory in 5xFAD mice on the Morris water maze.ConclusionsC3-hydroxylated pterosins, as activators of PKA, have substantial potential as disease-modifying/-slowing therapeutic agent for AD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251344627"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is frustrating the search for treatment of dementia? Fraud or ideas? 是什么阻碍了痴呆症治疗的研究？欺诈还是创意？

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-02 DOI: 10.1177/13872877251346044

Jonathan Stone

引用次数: 0

Glutathione peroxidase activity in Alzheimer's disease patients: A systematic review and meta-analysis. 阿尔茨海默病患者谷胱甘肽过氧化物酶活性：系统回顾和荟萃分析。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-02 DOI: 10.1177/13872877251346981

Meire Ellen Pereira, Júlia Vicentin de Souza, Gabriella Giandotti Gomar, Isabeli Lopes Kruk, Cláudia Sirlene Oliveira

{"title":"Glutathione peroxidase activity in Alzheimer's disease patients: A systematic review and meta-analysis.","authors":"Meire Ellen Pereira, Júlia Vicentin de Souza, Gabriella Giandotti Gomar, Isabeli Lopes Kruk, Cláudia Sirlene Oliveira","doi":"10.1177/13872877251346981","DOIUrl":"https://doi.org/10.1177/13872877251346981","url":null,"abstract":"BackgroundOxidative stress can trigger and even aggravate Alzheimer's disease (AD). Glutathione peroxidase (GPX) can regulate oxidative stress by controlling the accumulation of hydrogen peroxide.ObjectiveThis study aimed to evaluate the GPX activity in patients with AD through a systematic review and meta-analysis.MethodsFollowing the PRISMA guidelines, data were retrieved from four electronic databases, including those containing cohort and case-control studies, published up to December 2024. Statistical analyses were conducted using RevMan, and risk of bias was evaluated with the Newcastle-Ottawa Scale.ResultsA total of 1999 scientific papers were collected, and 30 papers were included in this systematic review; 20 were included in the meta-analysis. GPX activity was measured in different tissues, such as erythrocytes, plasma, and postmortem brain. The analyses showed that erythrocytes and plasma GPX activity in most studies were inhibited in AD patients compared to healthy controls.ConclusionsThe analyses showed that GPX activity was decreased in AD patients compared to healthy controls in most of the included studies. More detailed research is needed to better assess the effects of GPX activity on AD-associated cognitive impairment and oxidative stress.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251346981"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0