Journal of Alzheimer's Disease最新文献

{"title":"The effects of two Alzheimer's disease related genes <i>APOE</i> and <i>MAPT</i> in healthy young adults: An attentional blink study.","authors":"Jianmin Zeng, Ziyun Gao, Xiong Xiong, Xingrong Hou, Huihui Qin, Yong Liu, Howard Bowman, Craig Ritchie, John T O'Brien, Li Su","doi":"10.1177/13872877241299124","DOIUrl":"10.1177/13872877241299124","url":null,"abstract":"<p><strong>Background: </strong>Genetic risk factors start to affect the brain and behavior in Alzheimer's disease (AD) before clinical symptoms occur. Although AD is mainly associated with memory deficits, attention and executive dysfunctions can present at the early presymptomatic stages in middle age for those with non-modifiable risks.</p><p><strong>Objective: </strong>Here, we investigated whether known risk genes for AD already affected attention in young adulthood.</p><p><strong>Methods: </strong>A total of 392 healthy young adults aged around 20 years underwent genetic testing for risks of dementia (<i>APOE</i> and <i>MAPT</i>) and performed a computerized cognitive test for temporal attention called the Attentional Blink (AB) task, in which patients with dementia tested in previous studies often showed reduced performance. Here, the AB task was analyzed using repeated-measurements analysis of variance for the ability of visual perception, attention deployment and temporal memory encoding/binding performance.</p><p><strong>Results: </strong>The results showed that all participants exhibited AB effects. Importantly, genetic risk factors had statistically significant influence on temporal attention depending on sex in healthy young adults. <i>APOE4</i> status was associated with enhanced attention deployment in males but not females, while <i>MAPT</i> AA carriers had poorer performance in AB but only in females. No genetic effects were found for visual perception and temporal memory binding errors between high and low risk groups.</p><p><strong>Conclusions: </strong>We provided evidence that both <i>APOE</i> and <i>MAPT</i> start to affect attentional function as early as young adulthood. Furthermore, unlike previous findings in older people, these genes had a differential effect for males and females in young adults.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"167-179"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality interventions and their effects on the cognition of individuals with Alzheimer's disease: A systematic review and meta-analysis.","authors":"Vanessa Daudt Santos, Adriana Coelho Costa, Nelson Carvas Junior, François Jean Delaere, Sebàstien Serlet, Marcia Cristina Nascimento Dourado","doi":"10.1177/13872877241299037","DOIUrl":"10.1177/13872877241299037","url":null,"abstract":"<p><strong>Background: </strong>Dementia due to Alzheimer's disease (AD) is the most prevalent neurocognitive disorder in the world and impacts the individual's cognitive functions and functionality in the early stages of the condition. Virtual reality (VR) interventions can assist in non-pharmacological treatment in a more ecological way, positively impacting cognitive abilities. However, there are few studies on VR exclusively involving people with AD in randomized controlled trials.</p><p><strong>Objective: </strong>To evaluate the effects of VR intervention on the cognitive functions of people with AD.</p><p><strong>Methods: </strong>A systematically conducted search was carried out in MEDLINE, EMBASE, BVS, Web of Science, and Scopus. Eligible studies were randomized controlled trials comparing the efficacy of VR and traditional cognitive interventions in people with AD. Methodologic quality was assessed with the Cochrane risk of bias tool, and outcomes were calculated as risk ratios (for dichotomous outcomes) and mean differences (for continuous outcomes) with 95% confidence interval.</p><p><strong>Results: </strong>A total of three randomized controlled trials with 75 participants were included. An improvement in the performance of the VR group was observed in memory, especially when comparing the usual treatment [MD = 0.99; CI95%: 0.33; 1.66; I²= 0%]. VR has little or no effect on participants' executive function [MD = 1.36; 95%CI: -1.12; 3.85; I²= 0%] compared to the usual treatment.</p><p><strong>Conclusions: </strong>Our study results cautiously suggest, despite the small number of participants, that VR intervention may be a suitable memory treatment for individuals diagnosed with AD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"68-80"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ensuring continuity of care in times of crisis: A longitudinal analysis of dementia care delivery during armed conflict.","authors":"Zorian Radomyslsky, Sara Kivity, Yaniv Alon, Mor Saban","doi":"10.1177/13872877241299123","DOIUrl":"10.1177/13872877241299123","url":null,"abstract":"<p><strong>Background: </strong>Individuals with dementia are particularly vulnerable during emergency situations due to challenges with cognition, mobility, and daily functioning. However, little is known about how disruptive events may specifically impact the health of those with dementia.</p><p><strong>Objective: </strong>To evaluate changes in health outcomes for individuals with and without dementia surrounding the Israel-Gaza war in October 2023. Specifically, we analyzed and compared changes in mental health status, medication adherence, healthcare service utilization, and associated costs between individuals with dementia (Study Group) and those without dementia (Control Group) during the period surrounding the Israel-Gaza war in October 2023.</p><p><strong>Method: </strong>A prospective cohort study compared outcomes between individuals with dementia (Study Group, n = 24,178) and without (Control Group, n = 250,652) before and after the crisis onset. The conflict precipitously threw national systems into disarray, recruited healthcare personnel to the war effort, and disrupted supply chains.</p><p><strong>Results: </strong>Compared to baseline, analysis revealed alterations in patterns of dementia diagnoses, healthcare service utilization, medication adherence, and associated costs during the crisis period for both groups. However, the Study Group experienced comparatively larger declines.</p><p><strong>Conclusions: </strong>Findings provide insights into how humanitarian emergencies, through disruption of health systems and care networks, differentially impact continuity of dementia care. This underscores the need for tailored crisis response strategies to address the heightened vulnerabilities of patients with dementia.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"159-166"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer's disease prediction and prevention in a public health perspective: Ethical considerations and collaborations beyond the biomedical paradigm.","authors":"Dorothee Horstkötter","doi":"10.1177/13872877241308299","DOIUrl":"https://doi.org/10.1177/13872877241308299","url":null,"abstract":"<p><p>The prevention of dementia is increasingly a task for public health promotion and aims at the general public. This likewise holds for potentially modifiable lifestyle risk factors and biomarkers indicating susceptibility. This commentary argues that from a public health ethical perspective, there is a significant overlap between the implications and requirements of the biomedical domain and lifestyle approaches. What's more, once public awareness of Alzheimer's disease prevention or risk reduction is further established, the public will likely intermix options and advice. Public health ethical recommendations should pro-actively reflect on upcoming questions, concerns, and remedies, combine but not separate both domains and anticipate their conceivable interactions.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877241308299"},"PeriodicalIF":3.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of adapted dance on mood and physical function among persons living with Alzheimer's disease.","authors":"Crystal G Bennett, Rodney P Guttmann, Madeleine E Hackney, Raid Amin, Savannah Weaver","doi":"10.1177/13872877241298529","DOIUrl":"https://doi.org/10.1177/13872877241298529","url":null,"abstract":"<p><strong>Background: </strong>Most individuals living with Alzheimer's disease and related dementias (ADRD) experience one or more neuropsychiatric symptoms, such as agitation which negatively impacts their quality of life. Adapted dance integrates recorded music and movement that is appropriate for people with cognitive limitations. Adapted dance may be an enjoyable activity for persons living with ADRD and may provide psychological and physical benefits.</p><p><strong>Objective: </strong>The purpose of this pilot study was to assess the feasibility of an adapted dance intervention with persons with ADRD and the impacts of 12 weeks of adapted dancing on agitation, balance, gait, lower extremity strength, and caregiver burden.</p><p><strong>Methods: </strong>This study used an experimental design with repeated measures. Participants with ADRD were randomly assigned to a usual care or adapted line dance group that met 60 min twice a week. At pre-test, 4-, 8-, and 12 weeks of intervention, measures were collected for agitation, balance, gait, lower extremity strength, and caregiver burden.</p><p><strong>Results: </strong>The sample consisted of 4 males and 12 females (n = 16) with ADRD whose age ranged from 69-97 years. Twelve weeks of adapted line dance was found acceptable by ADRD participants. Participants attended ≥90% of dance sessions and did not experience loss of balance or fall. ADRD participants danced an average of 70 min per week. Both groups had improvements in agitation from baseline to 12 weeks.</p><p><strong>Conclusions: </strong>Twelve weeks of adapted dance was shown to be feasible and enjoyable for persons living with ADRD. Clinicians should consider adapted dance as part of an exercise prescription.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877241298529"},"PeriodicalIF":3.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal neuroimaging biomarkers and subtle cognitive decline in a population-based cohort without dementia.","authors":"Andrea M Weinstein, Fang Fang, Chung-Chou H Chang, Ann Cohen, Brian J Lopresti, Charles M Laymon, Neelesh K Nadkarni, Howard J Aizenstein, Victor L Villemagne, M Ilyas Kamboh, C Elizabeth Shaaban, Marissa A Gogniat, Minjie Wu, Thomas K Karikari, Mary Ganguli, Beth E Snitz","doi":"10.1177/13872877241303926","DOIUrl":"https://doi.org/10.1177/13872877241303926","url":null,"abstract":"<p><strong>Background: </strong>The relationship between subtle cognitive decline and Alzheimer's disease (AD) pathology as measured by biomarkers in settings outside of specialty memory clinics is not well characterized.</p><p><strong>Objective: </strong>To investigate how subtle longitudinal cognitive decline relates to neuroimaging biomarkers in individuals drawn from a population-based study in an economically depressed, small-town area in southwestern Pennsylvania, USA.</p><p><strong>Methods: </strong>A subset of participants without dementia (N = 115, age 76.53 years ± 6.25) from the Monongahela Youghiogheny Healthy Aging Team (MYHAT) study completed neuroimaging including magnetic resonance imaging (MRI) measures of AD-signature region cortical thickness and white matter hyperintensities (WMH), Pittsburgh compound B (PiB)-positron emission tomography (PET) for amyloid-β (Aβ) deposition, and [¹⁸F]AV-1451-PET for tau deposition. Neuropsychological evaluations were completed at multiple timepoints up to 11 years prior to neuroimaging. Aβ positivity was determined using a regional approach. We used linear mixed models to examine neuroimaging biomarker associations with retrospective cognitive slopes in five domains and a global cognitive composite.</p><p><strong>Results: </strong>Among Aβ(+) participants (38%), there were associations between (i) tau Braak III/IV and language decline (p < 0.05), (ii) cortical thickness and both memory decline (p < 0.001) and global cognitive decline (p < 0.01), and (iii) WMH and decline in executive function (p < 0.05) and global cognition (p < 0.05). Among Aβ(-) participants, there was an association between tau Braak III/IV and decline on tests of attention/psychomotor speed (p < 0.05).</p><p><strong>Conclusions: </strong>These findings confirm an Aβ-dependent early AD biomarker pathway, and suggest a possible Aβ-independent, non-AD process underlying subtle cognitive decline in a population-based sample of older adults without dementia.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877241303926"},"PeriodicalIF":3.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive function and its longitudinal predictability by intensity of physical activity in Chinese middle-aged and older adults.","authors":"Worku Animaw Temesgen, Ho Yu Cheng, Yuen Yu Chong","doi":"10.1177/13872877241305828","DOIUrl":"https://doi.org/10.1177/13872877241305828","url":null,"abstract":"<p><strong>Background: </strong>The aging population faces several health problems, including cognitive decline that can progress to Alzheimer's disease. Regular physical activity is widely recognized for its extensive benefits, including physical and mental health improvements especially for older adults.</p><p><strong>Objective: </strong>This study aimed to examine the prediction of physical activity intensities on cognitive function of older adults.</p><p><strong>Methods: </strong>Data from 8 years prospective survey among Chinese population aged 45 years and older is used. Cognitive function was measured by word recall, orientation, numeric subtraction, and copying a picture. Physical activity was assessed with three intensity levels. General estimating equations (GEE) with unstructured correlation matrix is used to test the prediction of physical activity intensity on cognitive function.</p><p><strong>Results: </strong>Cognitive function of participants significantly declined from 9.81 at baseline to 8.81 after 8 years. Moderate-intensity physical activity for 3 days/week was strongest positive predictor of cognitive function with a betta coefficient of 0.64. Light-intensity physical activity also positively predicted cognitive function, however vigorous physical activity for more than 3 days/week negatively predicted cognitive function.</p><p><strong>Conclusions: </strong>Cognitive function of the Chinese population is found to continuously decline after 60 years old age. Fortunately, this decline can be delayed with age-tolerable light to moderate-intensity physical activities.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877241305828"},"PeriodicalIF":3.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory study of French healthcare workers' experiences of anosognosia in Alzheimer's disease and related disorders.","authors":"Julie Vignolo, Jean-Pierre Jacus, Thierry Darnaud, Christine Vanessa Cuervo-Lombard","doi":"10.1177/13872877241307045","DOIUrl":"https://doi.org/10.1177/13872877241307045","url":null,"abstract":"<p><strong>Background: </strong>Anosognosia or lack of insight is a common feature of Alzheimer's disease (AD) and associated disorders. It is an impairment in the ability to recognize the disease and related symptoms. Anosognosia is associated among patients with poor compensatory strategies, behavioral disorders, apathy and caregiver burden. Therefore, its early identification by healthcare workers is a major challenge in order to provide support for both patients and caregivers.</p><p><strong>Objective: </strong>To explore the knowledge, attitudes and experiences of French healthcare workers relating to anosognosia in AD and related disorders.</p><p><strong>Methods: </strong>An online self-completed questionnaire was created for the study. It was anonymous and divided into three dimensions: general knowledge, confidence, and subjective experiences of anosognosia. One hundred and eleven healthcare workers completed the questionnaire. Mann Whitney and Kruskal Wallis tests were used to determine the variables associated with the total knowledge and confidence scores. Ordinal logistic regressions were performed to explore the associations between subjective experiences and demographics.</p><p><strong>Results: </strong>The participants had moderate knowledge. Knowledge scores were influenced by their experience in the geriatric field, type of profession, workplaces and training. The areas where knowledge was poorest were anosognosia assessment and management. The participants with the lowest knowledge levels were those interacting the most with patients, especially at home. Overall, they identified difficulties related to anosognosia and did not seem confident about their ability to deal with this condition.</p><p><strong>Conclusions: </strong>This study determines specific areas for training on anosognosia, such as identification, assessment and management of this condition.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877241307045"},"PeriodicalIF":3.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of visit-to-visit blood pressure variability and time in target range in predicting risk for cognitive outcomes in the SPRINT trial.","authors":"Isabel J Sible, Daniel A Nation","doi":"10.1177/13872877241303378","DOIUrl":"https://doi.org/10.1177/13872877241303378","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure (BP) variability (BPV) and time in target range (TTR) are emerging vascular risk factors for dementia, independent of traditionally targeted mean BP.</p><p><strong>Objective: </strong>Determine whether BPV or TTR is most strongly associated with cognitive risk.</p><p><strong>Methods: </strong>In this post hoc analysis of the SPRINT trial, 8034 participants underwent repeated BP measurement and cognitive testing at baseline and follow-up. Visit-to-visit BPV was calculated as average real variability. TTR was the percent of time in desired treatment arm target range (standard: 120-140 mmHg systolic BP; intensive: 110-130 mmHg systolic BP). Adjudicated clinical outcomes were no cognitive impairment, mild cognitive impairment (MCI), and probable dementia. We investigated a direct comparison of BPV and TTR in predicting cognitive risk, stratified by BP treatment group.</p><p><strong>Results: </strong>Elevated BPV was associated with increased risk for MCI (adjusted HR: 1.21 [95% CI 1.10, 1.33], <i>p </i>< 0.001) and MCI/dementia (HR: 1.17 [95% CI 1.07, 1.27], <i>p </i>< 0.001) in the standard group, and dementia (HR: 1.17 [95% CI 1.01, 1.36], <i>p </i>= 0.039) in the intensive group. Higher TTR was related to lower dementia risk (HR: 0.72 [95% CI 0.60, 0.86], <i>p </i>< 0.001) in the intensive group only.</p><p><strong>Conclusions: </strong>Visit-to-visit BPV outperformed TTR in predicting risk for MCI and MCI/dementia. TTR was more strongly associated with dementia risk under intensive treatment. Findings were independent of mean BP in a cohort with rigorously controlled BP and suggest newer aspects of BP control may be harnessed to further reduce cognitive risk.</p><p><strong>Clinical trial information: </strong>ClinicalTrials.gov; NCT01206062.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877241303378"},"PeriodicalIF":3.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142836523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Item response theory for the color-picture version of Boston naming test in a Chinese sample with neurodegenerative diseases.","authors":"Dan Li, Xining Liu, Jiaming Yu, Yifei Zhang, Nan Hu, Yuanyuan Lu, Fangling Sun, Min Zhang, Xiaowei Ma, Fen Wang","doi":"10.1177/13872877241305820","DOIUrl":"https://doi.org/10.1177/13872877241305820","url":null,"abstract":"<p><strong>Background: </strong>Although Boston Naming Test has been thoroughly validated at a global level, there is limited assessment of item-level properties using modern psychometric methods.</p><p><strong>Objective: </strong>This study aimed to investigate the construct validity and item-level properties of the color-picture version of Boston Naming Test (CP-BNT) in a Chinese cohort with neurodegenerative diseases.</p><p><strong>Methods: </strong>This retrospective study included 424 participants, consisting of 118 normal controls, 152 with Alzheimer's disease, 101 with primary progressive aphasia, and 53 with other neurodegenerative diseases. All participants underwent a comprehensive neuropsychological assessment that included the CP-BNT. Factor analysis and item response theory were conducted.</p><p><strong>Results: </strong>The CP-BNT exhibits a multidimensional structure with three factors: Factor 1, consisting of nine items with moderate difficulty levels, demonstrated peak measurement function for mild anomia (the highest information value = 33.7, ability estimated value = -0.8, reliability = 0.97); Factor 2, comprising eleven items with lower difficulty levels, performed well in cases of mild to moderate anomia (the highest information value = 34.1, ability estimated value = -1.2, reliability = 0.97); and Factor 3, including ten items with higher difficulty levels, provided the most measurement information for normal naming (the highest information value = 9.9, ability estimated value = 0, reliability = 0.90). All items, except item <i>igloo</i>, showed good discrimination (discrimination parameter ranged from 5.46 to 1.15). Most items had a different difficulty position versus the original version, thereby generating a novel item sequence with an ascending difficulty hierarchy for Chinese samples.</p><p><strong>Conclusions: </strong>These findings support that the CP-BNT has good validity, reliability, and cultural appropriateness in the Chinese context, improving its utility in clinical assessments and interventions.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877241305820"},"PeriodicalIF":3.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142836553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}