Journal of Alzheimer's Disease最新文献_第9页

Interpersonal synchrony in dance/movement therapy: Neural underpinnings for individuals with dementia. 舞蹈/运动疗法中的人际同步：痴呆症患者的神经基础。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-17 DOI: 10.3233/JAD-240239

Rebekka Dieterich-Hartwell

引用次数: 0

Exploring the association between physical activity and cognitive function among people living with dementia. 探索痴呆症患者的体育锻炼与认知功能之间的关系。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-17 DOI: 10.3233/JAD-230594

Deborah A Jehu, Faheem Pottayil, Yanbin Dong, Haidong Zhu, Richard Sams, Lufei Young

{"title":"Exploring the association between physical activity and cognitive function among people living with dementia.","authors":"Deborah A Jehu, Faheem Pottayil, Yanbin Dong, Haidong Zhu, Richard Sams, Lufei Young","doi":"10.3233/JAD-230594","DOIUrl":"10.3233/JAD-230594","url":null,"abstract":"BackgroundPhysical activity preserves cognitive function in people without dementia, but the relationship between physical activity and cognitive domains among people living with dementia is unclear.ObjectiveThe objective of this study was to explore the association between physical activity and cognition domains among people living with dementia.MethodsParticipants living with dementia in residential care facilities (complete case analysis: n = 24/42) completed a battery of cognitive tests (global cognition: Montreal Cognitive Assessment; executive function: Trail-Making Test, Digit Span Forward Test; perception and orientation: Benton Judgement of Line Orientation Test; language: Boston Naming Test; learning and memory: Rey Auditory Verbal Learning Test; complex attention: Digit Symbol Substitution Test). Participants wore an actigraphy monitor on their non-dominant wrist over seven days. We conducted a linear regression for total physical activity (independent variable) with race (white/black), fall risk (Morse Fall Scale), and the number of comorbidities (Functional Comorbidities Index) as covariates, and cognitive tests as variables of interest.ResultsParticipants were primarily male (75%), white (87.5%), and 50%had unspecified dementia (Alzheimer's disease: 33%). Greater physical activity was associated with poorer global cognition, better executive function, and better learning and memory (ps < 0.05). Physical activity was not related to visuospatial perception, language, or complex attention.ConclusionsPhysical activity may preserve executive function and learning and memory among people living with dementia. Wandering is more common in later stages of dementia, which may explain greater physical activity observed with lower global cognition. Regularly assessing physical activity may be useful in screening and monitoring cognitive changes.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"JAD230594"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139741096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The management of mild neurocognitive disorder in primary care: A Delphi consensus study. 初级保健中轻度神经认知障碍的管理：德尔菲共识研究。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-17 DOI: 10.1177/13872877251322750

Davide Quaranta, Camillo Marra, Enrico Mossello, Alessandro Pirani, Annachiara Cagnin, Federico Adinolfi, Stefano Remiddi

{"title":"The management of mild neurocognitive disorder in primary care: A Delphi consensus study.","authors":"Davide Quaranta, Camillo Marra, Enrico Mossello, Alessandro Pirani, Annachiara Cagnin, Federico Adinolfi, Stefano Remiddi","doi":"10.1177/13872877251322750","DOIUrl":"https://doi.org/10.1177/13872877251322750","url":null,"abstract":"BackgroundStrategies to identify and treat mild neurocognitive disorder (mild NCD) are still unclear.ObjectiveThe detection and management of mild NCD are crucial to prevent or delay its progression to major NCD, and to help those affected cope with cognitive impairment. The Cartesio Project aimed to reach a consensus on the management of mild NCD in primary care.MethodsThe Advisory Board of five experts (three neurologists, one geriatrician and one general practitioner (GP)), identified four domains of mild NCD: case finding; differential diagnosis; non-pharmacological, and pharmacological intervention. A literature review was performed by consulting the PubMed, PsycNET and Scopus databases from 2017 until August 2022, and guidelines, reviews and meta-analyses on mild NCD were reviewed. A care pathway involving 18 statements was then proposed and voted on by 61 participants (39% neurologists, 31% geriatricians, 25% GPs and 5% psychiatrists).ResultsAgreement was reached on 14 out of 18 statements. The practice of case finding in primary care and the need for a two-level diagnostic approach was supported, including referral to memory clinics. With regard to non-pharmacological treatments, no consensus was reached on nutritional supplementation. There was support for the use of nootropic drug treatments, but not for drugs to treat Alzheimer's disease.ConclusionsThe Cartesio Project developed a consensus to identify the best care for mild NCD. The consensus highlights educational interventions on timely detection and appropriate management of mild NCD in primary care, which may be of relevance for those patients who eventually develop Alzheimer's disease.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251322750"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic associations of amyloid-β and phosphorylated tau with tau aggregation and cognitive decline in Alzheimer's disease. 淀粉样蛋白β和磷酸化tau蛋白与阿尔茨海默病中tau蛋白聚集和认知能力下降的协同关联

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-17 DOI: 10.1177/13872877251322196

Chunhua Zhang, Yaojun Tai, Min Kong, Pengyuan Jia, Guozhao Ma, Maowen Ba

{"title":"Synergistic associations of amyloid-β and phosphorylated tau with tau aggregation and cognitive decline in Alzheimer's disease.","authors":"Chunhua Zhang, Yaojun Tai, Min Kong, Pengyuan Jia, Guozhao Ma, Maowen Ba","doi":"10.1177/13872877251322196","DOIUrl":"https://doi.org/10.1177/13872877251322196","url":null,"abstract":"BackgroundThe pathological hallmarks of Alzheimer's disease (AD) include the amyloid-β (Aβ) plaques and phosphorylated tau (p-tau) forming neurofibrillary tangles. Understanding the pathophysiological cascade related to Aβ and tau process is crucial.ObjectiveTo investigate the impact of Aβ positron emission tomography (PET) and cerebrospinal fluid (CSF) p-tau on tau pathology and cognitive decline in AD.MethodsWe analyzed 319 older individuals from the Alzheimer's Disease Neuroimaging Initiative (ADNI) who underwent Aβ (18F-florbetapir or 18F-florbetaben) and tau (18F-flortaucipir) PET scans, along with CSF and cognitive assessments. Aβ positivity (A+) was determined by global standardized uptake value ratio thresholds of ≥1.11 for 18F-florbetapir or ≥1.08 for 18F-florbetaben, while p-tau positivity (T+) was defined as CSF p-tau181 levels ≥23 pg/ml. Linear mixed regression models were used to assess the effects of PET Aβ and CSF p-tau181 levels on tau accumulation in predefined Braak regions and cognitive function over time.ResultsOur results revealed significant differences in PET tau pathology and cognitive decline between A + and A- individuals. We observed that interactions between Aβ and p-tau proteins were associated with tau accumulation and cognitive decline. Additionally, A-/T + individuals exhibited higher levels of tau accumulation in all Braak regions compared to A-/T- counterparts, suggesting a potential independent role of p-tau in tau pathology in the absence of Aβ.ConclusionsOur findings suggest that Aβ positivity and elevated CSF p-tau181 levels were associated with tau accumulation and cognitive decline, highlighting the relevance of soluble p-tau as a potential biomarker for further investigation.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251322196"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in transcriptional regulation in the temporal lobe in patients with Alzheimer's disease. 阿尔茨海默病患者颞叶转录调节的变化。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-17 DOI: 10.1177/13872877251322536

Yujie Yang, Yinhu Li, Yu Chen

{"title":"Changes in transcriptional regulation in the temporal lobe in patients with Alzheimer's disease.","authors":"Yujie Yang, Yinhu Li, Yu Chen","doi":"10.1177/13872877251322536","DOIUrl":"https://doi.org/10.1177/13872877251322536","url":null,"abstract":"BackgroundAlzheimer's disease (AD) is a complex neurodegenerative disorder with intricate pathophysiological mechanisms. Transcriptome analysis has been used to investigate the pathogenesis of AD from the perspectives of mRNA expression, alternative splicing, and alternative polyadenylation. However, these 3 transcriptomic regulatory layers have not been comprehensively explored, limiting our understanding of the transcriptomic landscapes of AD pathogenesis.ObjectiveWe aimed to describe the transcriptomic landscapes of AD pathogenesis, detect the contributions of different regulatory layers to the total transcriptional variance, and identify diagnostic candidates for AD prediction.MethodsWe collected RNA sequencing data derived from the temporal lobes of 257 patients with AD and 97 controls, performed joint transcriptional analysis with multi-omics factor analysis (MOFA2) and weighted gene co-expression network analysis (WGCNA), and evaluated the signals with regression models.ResultsWe found that increasing Braak stage is associated with progressive downregulation of SYT1, CHN1, SNAP25, VSNL1, and ENC1 as well as upregulation of TNS1, SGK1, CPM, PPFIBP, and CLMN. Subsequent MOFA2 revealed that alternative splicing contributes most (R2 = 0.558) to the transcriptional variance between patients with AD and controls followed by alternative polyadenylation (R2 = 0.449) and mRNA expression (R2 = 0.438). In addition, the regression model constructed with SNAP25, VSNL1, and ENC1 expression could distinguish between patients with AD and controls (AUC = 0.752).ConclusionsWe systematically detailed the transcriptional landscapes in patients with AD and report mRNA signals associated with AD, offering novel insights into AD pathogenesis and therapeutic development.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251322536"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of cardiovascular-kidney-metabolic health and apolipoprotein E4 genotype with risk of dementia and mortality. 心血管-肾脏-代谢健康和载脂蛋白E4基因型与痴呆和死亡风险的关系

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-17 DOI: 10.1177/13872877251324093

Xinghe Huang, Jie Liang, Junyu Zhang, Jiayi Fu, Yige Chen, Wuxiang Xie, Fanfan Zheng

{"title":"Association of cardiovascular-kidney-metabolic health and apolipoprotein E4 genotype with risk of dementia and mortality.","authors":"Xinghe Huang, Jie Liang, Junyu Zhang, Jiayi Fu, Yige Chen, Wuxiang Xie, Fanfan Zheng","doi":"10.1177/13872877251324093","DOIUrl":"https://doi.org/10.1177/13872877251324093","url":null,"abstract":"BackgroundPoor cardiovascular-kidney-metabolic (CKM) health is becoming prevalent; however, sparse data exist regarding the association of CKM health with incident dementia and all-cause mortality.ObjectiveThis study aimed to examine whether poor CKM health is associated with a higher risk of dementia and all-cause mortality, regardless of APOE4 carrier status.MethodsIn this prospective cohort study, 352,364 participants from the UK Biobank were included. CKM syndrome was identified as a medical condition with the presence of metabolic risk factors, cardiovascular disease, and chronic kidney disease, and was classified into five stages (stage 0 to 4). Cox proportional hazards models were applied to explore the association of CKM health with incident dementia and all-cause mortality.ResultsParticipants in stage 2-3 and stage 4 had 1.12-fold (95% CI: 1.02-1.23, p = 0.023) and 2.18-fold (95% CI: 1.96-2.43, p < 0.001) increased risk of incident all-cause dementia compared with those in stage 0. Similarly, participants in stage 4 also had an increased risk of Alzheimer's disease (HR = 1.51, 95% CI: 1.28-1.78, p < 0.001) and vascular dementia (HR = 4.62, 95% CI: 3.54-6.03, p < 0.001). Participants in later stages were at higher risk of all-cause mortality. We found an interaction between CKM health and APOE4 carrier status (p for interaction <0.001), and the relationship between CKM health and dementia was more pronounced in non-APOE4 carriers. Moreover, there were significant additive interactions between APOE4 carrier status and CKM health on the risk of dementia.ConclusionsPoor CKM health is independently associated with an increased risk of dementia, regardless of APOE4 carrier status, and all-cause mortality. These findings imply that promoting CKM health may help to reduce the risk of subsequent dementia and mortality.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251324093"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The associations of cerebrospinal fluid ApoE and C1q with Alzheimer's disease biomarkers. 脑脊液ApoE和C1q与阿尔茨海默病生物标志物的关系

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-17 DOI: 10.1177/13872877251320419

Yu-Jing Lin, Ying Liu, Ze-Hu Sheng, Yan Fu, Ling-Zhi Ma, Zi-Hao Zhang, Lan-Yang Wang, Liang-Yu Huang, Min Liu, Zuo-Teng Wang, Lan Tan

{"title":"The associations of cerebrospinal fluid ApoE and C1q with Alzheimer's disease biomarkers.","authors":"Yu-Jing Lin, Ying Liu, Ze-Hu Sheng, Yan Fu, Ling-Zhi Ma, Zi-Hao Zhang, Lan-Yang Wang, Liang-Yu Huang, Min Liu, Zuo-Teng Wang, Lan Tan","doi":"10.1177/13872877251320419","DOIUrl":"https://doi.org/10.1177/13872877251320419","url":null,"abstract":"BackgroundThe roles of complement 1q (C1q) and Apolipoprotein E (ApoE) in driving Alzheimer's disease (AD) progression might be explained by their associations with neuroinflammation and AD pathology which were previously reported.ObjectiveWe examined the associations of cerebrospinal fluid (CSF) C1q and ApoE with CSF neuroinflammatory biomarkers and AD core biomarkers, as well as explored whether C1q mediated the associations of CSF ApoE with these biomarkers.MethodsHere, we analyzed CSF proteomics data from Alzheimer's Disease Neuroimaging Initiative (ADNI) using two different ADNI proteomics datasets-SomaScan (n = 579)and multiple reaction monitoring (MRM[n = 207]). Linear regression analyses were conducted to explore the association of CSF ApoE and C1q. The mediation model and structural equation model (SEM) were conducted to explore the associations of ApoE and C1q with AD biomarkers.ResultsMultiple linear regression showed that CSF ApoE was positively associated with CSF C1q in total participants and Alzheimer's continuum participants. Mediation analyses indicated that C1q mediated the associations of CSF ApoE with CSF T-tau, P-tau, sTREM2 and GFAP (mediation proportions range from 15.06 to 44.64%; all the p values < 0.05) but not with CSF amyloid-β and progranulin (PGRN). The SEM yielded similar results.ConclusionsOur findings suggest that C1q is linked to ApoE, and it mediates the associations of ApoE with T-tau, P-tau, sTREM2, GFAP, indicating C1q association with ApoE might be involved in AD progression.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251320419"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Western Mediterranean diet predicts 9-year changes in episodic memory in an adult lifespan sample of Americans. 西式地中海饮食可预测美国成人寿命样本中外显记忆的 9 年变化。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-17 DOI: 10.1177/13872877251320861

Kelly Rb Parker, Ryan McGrath, Yeong Rhee, Jeremy Hamm

{"title":"Western Mediterranean diet predicts 9-year changes in episodic memory in an adult lifespan sample of Americans.","authors":"Kelly Rb Parker, Ryan McGrath, Yeong Rhee, Jeremy Hamm","doi":"10.1177/13872877251320861","DOIUrl":"https://doi.org/10.1177/13872877251320861","url":null,"abstract":"BackgroundThe Mediterranean Diet (MD) is well-studied for slowing cognitive declines. Few studies have examined how a Western MD (wMD) may impact cognitive function.ObjectiveThis study examined whether a wMD predicted less cognitive decline over 9 years in a national sample of American adults. The measures were episodic memory (EM) and executive functioning (EF) at baseline and 9 years follow-up.MethodsThis is a secondary analysis of the Midlife in the United States Study (MIDUS), using a longitudinal cohort design with cross-sectional dietary data. Participants in this study had data from Waves 2 and 3 of MIDUS (n = 833, 46 ± 12 years; 45% male). Regression analyses tested whether wMD adherence predicted 9-year changes in EM and EF. Moderator analyses determined whether the relationship between wMD, EM, and EF differed across sociodemographic characteristics.ResultswMD score at Wave 2 predicted attenuated declines in EM 9 years later (β = 0.06, p = 0.04). The association between wMD and EM was not moderated by age, sex, race, education, or income and thus is consistent across sociodemographic subpopulations. wMD did not predict EF (fully adjusted wMD β = 0.00, p = 0.86). Contextualized effect sizes showed that individuals who strongly adhered to the wMD (+1 SD) experienced ∼50-60% less decline in 9-year EM when compared to those with average adherence.ConclusionsA wMD was related to slowed EM declines across sociodemographic populations in a national U.S. sample. Education is needed about healthful dietary habits, including increased fruit and vegetable intake.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251320861"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Alzheimer's disease genetic risk with age-dependent changes in plasma amyloid-β_42:40 in Veterans. 退伍军人阿尔茨海默病遗传风险与血浆淀粉样蛋白-β42:40年龄依赖性变化的关系

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-14 DOI: 10.1177/13872877251321183

Meghan E Pierce, Mark Logue, Richard Sherva, Mark Miller, Bertrand R Huber, William Milberg, Jasmeet P Hayes

{"title":"Association of Alzheimer's disease genetic risk with age-dependent changes in plasma amyloid-β42:40 in Veterans.","authors":"Meghan E Pierce, Mark Logue, Richard Sherva, Mark Miller, Bertrand R Huber, William Milberg, Jasmeet P Hayes","doi":"10.1177/13872877251321183","DOIUrl":"https://doi.org/10.1177/13872877251321183","url":null,"abstract":"BackgroundIdentifying biomarkers of Alzheimer's disease (AD) is critical for early diagnosis and AD risk assessment.ObjectiveWe examined the hypothesis that the plasma amyloid-β 42 and 40 (Aβ42:40) ratio has a curvilinear relationship with age among individuals who are at higher genetic risk for AD.MethodsThis study investigated the relationship between plasma amyloid-β 42 and 40 (Aβ42:40) ratio and age in 315 men and women Veterans, including those at genetic risk for AD. Hierarchical regression models investigated linear and nonlinear relationships between age, genetic risk, and Aβ42:40.ResultsWe observed a curvilinear relationship between age and Aβ42:40 in individuals with higher genetic risk, characterized by an increase in the Aβ42:40 during midlife followed by a decrease in older age.ConclusionsThese findings highlight distinct patterns in Aβ metabolism among genetically predisposed individuals, suggesting that early metabolic shifts may play a role in the progression of AD. Understanding these nuanced changes is essential for refining the use of Aβ42:40 ratio as a biomarker, potentially leading to more accurate risk stratification and earlier intervention strategies in AD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251321183"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between neuropsychiatric symptoms and pathology in clinicopathologically defined Alzheimer's disease, Alzheimer's disease with Lewy bodies, and dementia with Lewy bodies. 临床病理学定义的阿尔茨海默病、伴路易体的阿尔茨海默病和伴路易体的痴呆症的神经精神症状与病理之间的关联。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-14 DOI: 10.1177/13872877251320670

Cecilia Tremblay, Neha Shakir, Nan Zhang, Charles H Adler, Holly A Shill, Shyamal Mehta, Erika Driver-Dunckley, Christine M Belden, Alireza Atri, Thomas G Beach, Geidy E Serrano, Parichita Choudhury

{"title":"Associations between neuropsychiatric symptoms and pathology in clinicopathologically defined Alzheimer's disease, Alzheimer's disease with Lewy bodies, and dementia with Lewy bodies.","authors":"Cecilia Tremblay, Neha Shakir, Nan Zhang, Charles H Adler, Holly A Shill, Shyamal Mehta, Erika Driver-Dunckley, Christine M Belden, Alireza Atri, Thomas G Beach, Geidy E Serrano, Parichita Choudhury","doi":"10.1177/13872877251320670","DOIUrl":"https://doi.org/10.1177/13872877251320670","url":null,"abstract":"BackgroundNeuropsychiatric symptoms (NPS) are frequent in Alzheimer's disease (AD) dementia, but a higher NPS burden is found in dementia with Lewy bodies (DLB). Lewy body (LB) pathology frequently co-occurs with AD pathology and may not meet neuropathological criteria for DLB (ADLB). NPS trajectories over disease course in these subgroups is not well understood.ObjectiveWe investigated changes in NPS severity over time, at two time points, comparing clinicopathologically defined cohorts of AD (without LB), ADLB, DLB, and controls.MethodsCases with two available Neuropsychiatric Inventory-Questionnaire (NPIQ), at the time of enrollment and within 2.5 years of death, were selected from the Arizona Study of Aging and Neurodegenerative Disorders. Differences and rate of change in NPIQ scores were compared between AD (n = 75), ADLB (n = 48) DLB (n = 65), and controls (n = 32) with covariates for age, sex, and cognition.ResultsFirst NPIQ scores were highest in ADLB when compared to AD (p = 0.04) and controls (p = 0.01) but not different from DLB. A significant increase in NPS severity was observed in DLB and AD (p < 0.001) over a mean follow up time of 4.9 ± 3.0 years, and the rate of change was significantly greater in DLB when compared to other groups. Final NPIQ scores were highest in DLB when compared to AD (p = 0.03) but not ADLB, and in DLB, ADLB, and AD than controls (all p < 0.001).ConclusionsEarly NPS burden as well as NPS severity progression rate, independently of cognitive status, might be useful clinical metrics and may help predict underlying pathological diagnoses.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251320670"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0