Journal of Alzheimer's Disease最新文献

{"title":"Association between plant-based dietary patterns and cognitive function in middle-aged and older residents of China.","authors":"Jianying Peng, Xiaolong Li, Jie Wang, Fengping Li, Jianfeng Gao, Yan Deng, Benchao Li, Tingting Li, Yuanyuan Li, Sui Tang, Likang Lu, Peiyang Zhou, Shuang Rong","doi":"10.1177/13872877241300253","DOIUrl":"10.1177/13872877241300253","url":null,"abstract":"<p><strong>Background: </strong>Plant-based diets may protect against cognitive impairment; however, observational data have not been consistent.</p><p><strong>Objective: </strong>This study aimed to evaluate the association between plant-based dietary patterns and cognitive function.</p><p><strong>Methods: </strong>The study recruited 937 participants who were asked to complete food frequency questionnaires to assess the quality of their plant-based diets using the overall plant-based diet index (PDI), the healthful PDI (hPDI), and the unhealthful PDI (uPDI). Cognitive function evaluated using the Montreal Cognitive Assessment (MoCA) test. Logistic regression was used to explore the association between plant-based dietary patterns and the prevalence of mild cognitive impairment (MCI), while multiple linear regression was used to analyze the association between plant-based dietary patterns and cognitive scores.</p><p><strong>Results: </strong>The prevalence of MCI was 26% among the 937 participants. There was a significant association between higher uPDI scores and higher odds of MCI, with Quintile 4 compared with Quintile 1 showing an odds ratio of 2.21 (95% confidence interval 1.35, 3.60). Higher uPDI scores were associated with a lower total MoCA score and poorer performance in various cognitive domains. There were no significant associations between the PDI, the hPDI, and cognitive function. Consuming whole grains, nuts, and eggs once a week or more were associated with a lower risk of MCI, whereas frequently consumption of pickled vegetables was associated with an increased risk of MCI.</p><p><strong>Conclusions: </strong>Unhealthy plant-based diets were associated with cognitive impairment, while whole grains, nuts, and eggs may protect cognitive function; pickled vegetables are associated with cognitive impairment.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"282-292"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142836512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnic and racial influences on blood biomarkers for Alzheimer's disease: A systematic review.","authors":"Daniel Kjaergaard, Anja Hviid Simonsen, Gunhild Waldemar, T Rune Nielsen","doi":"10.1177/13872877241299047","DOIUrl":"10.1177/13872877241299047","url":null,"abstract":"<p><strong>Background: </strong>Little is known about confounding factors influencing Alzheimer's disease (AD) blood biomarker concentrations.</p><p><strong>Objective: </strong>The objective of this systematic review was to explore the available evidence for the influences of ethnicity and race on AD blood biomarker concentrations.</p><p><strong>Methods: </strong>We conducted a comprehensive systematic search in PubMed and Web of Science databases spanning from inception until 15 June 2023. We included studies that utilized plasma or serum biomarkers (amyloid-β [Aβ], total tau [t-tau], phosphorylated tau [p-tau], neurofilament light [NfL], and glial fibrillary acidic protein [GFAP]), compared individuals with AD to healthy controls, and included a minimum of two ethnic or racial groups for comparison. A total of 10 studies were included in the qualitative synthesis. All studies were conducted in the US.</p><p><strong>Results: </strong>Seven studies reported differences in blood biomarker concentrations between ethnic or racial groups. However, after adjusting for medical conditions and social determinants of health, the differences became non-significant in two of the studies. The included studies differed in their included covariates and their statistical approaches, which complicated the interpretation of the observed differences.</p><p><strong>Conclusions: </strong>The available evidence suggests that ethnicity and race may influence blood biomarker concentrations. However, it remains unclear to what extent these differences are mediated by differences in social determinants of health and medical conditions. Future studies are needed to explore ethnic and racial differences in blood biomarkers, including studies in diverse samples outside the US.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"81-91"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tele-neuropsychological multidomain assessment in Italian people with cognitive disorders: Reliability and user satisfaction.","authors":"Miriana Maria Bressan, Anna Maria Musso, Tommaso Bovi, Bruno Bonetti, Chiara Zucchella","doi":"10.1177/13872877241300186","DOIUrl":"10.1177/13872877241300186","url":null,"abstract":"<p><strong>Background: </strong>Tele-neuropsychology has already been employed in neurocognitive disorders, however, in Italy, the evidence of its psychometric quality and satisfaction is still limited.</p><p><strong>Objective: </strong>This study aimed to: (1) evaluate the reliability of a standardized battery of neuropsychological screening and domain-specific tests delivered at home via videoconference to a sample of Italian people with cognitive disorders, compared with traditional face-to-face administration; (2) assess the feasibility and satisfaction about remote administration.</p><p><strong>Methods: </strong>This crossover study enrolled patients with subjective cognitive disorder, mild neurocognitive disorder, or dementia. All participants performed a brief neuropsychological screening assessment in face-to-face or remote mode. People with milder cognitive disorders (Mini-Mental State Examination ≥ 20) also performed an extended neuropsychological battery. After 15 days, each participant repeated the same assessment in the opposite mode. Finally, participants completed a satisfaction questionnaire.</p><p><strong>Results: </strong>114 participants were initially enrolled in the study and 100 individuals performed both face-to-face and remote assessments (14 dropouts). All neuropsychological tests showed agreement between the two modes of administration, except for the Digit Span Forward (<i>p </i>= 0.009) and oral-Symbol Digit Modalities Test (<i>p </i>< 0.001). According to Lin's concordance correlation coefficient (LCCCs), tests also showed good or excellent reliability (LCCCs between 0.609 and 0.964); only the Digit Span Backward and the Stroop test showed moderate reliability (LCCCs =0.514-0.441, respectively). Among 100 participants, 65 patients answered the satisfaction questionnaire, declaring high satisfaction for the remote evaluation.</p><p><strong>Conclusions: </strong>Tele-neuropsychology seems to work with in-home assessments among Italian patients with cognitive disorders and seems to be acceptable to them.</p><p><strong>Trial registration: </strong><i>ClinicalTrials.gov</i>, Identifier: NCT06078332 (October 17, 2023).</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"268-281"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional and prognostic associations of baseline [¹⁸F]GTP1 tau PET signal and white matter lesion volumes for cognitive and functional decline in prodromal-to-mild Alzheimer's disease.","authors":"Nancy E Ruiz-Uribe, Paul Manser, Brandon Butcher, Yihao Li, Mira Blendstrup, Suzanne Baker, Sandra Sanabria Bohorquez, Edmond Teng","doi":"10.1177/13872877241302497","DOIUrl":"10.1177/13872877241302497","url":null,"abstract":"<p><strong>Background: </strong>In Alzheimer's disease (AD), tau and white matter lesion pathology are associated with clinical severity and subsequent decline, but their relative relationships with clinical assessments remain uncertain.</p><p><strong>Objective: </strong>To examine cross-sectional and prognostic associations between baseline [¹⁸F]GTP1 tau positron emission tomography (PET) standardized uptake value ratio (SUVRs) and T1 white matter hypointensity (WMHypo) volumes with clinical indices.</p><p><strong>Methods: </strong>We analyzed participants with biomarker-confirmed prodromal (n = 127) or mild (n = 233) AD with baseline [¹⁸F]GTP1 tau PET and MRI and longitudinal Clinical Dementia Rating-Sum of Boxes (CDR-SB), 13-item version of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog13), Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Mini-Mental Status Examination (MMSE), and Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) data.</p><p><strong>Results: </strong>Higher baseline [¹⁸F]GTP1 SUVRs were independently associated with poorer baseline performance and faster rates of subsequent decline on all five clinical outcome measures. Higher baseline WMHypo volumes were independently associated with poorer baseline performance on the CDR-SB, ADAS-Cog13, RBANS, and MMSE and faster rates of subsequent decline on the CDR-SB and ADCS-ADL.</p><p><strong>Conclusions: </strong>The independent associations of tau and white matter lesion pathology with clinical decline in AD suggest future prognostic models should include both imaging modalities.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"465-475"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of formononetin as a novel natural agent in Alzheimer's disease and osteoporosis comorbidity.","authors":"Zhigang Wang, Qiaoyi Liang, Zhaoqiu Lin, Hongyang Li, Xin Chen, Zhenyou Zou, Jingxin Mo","doi":"10.1177/13872877241299104","DOIUrl":"10.1177/13872877241299104","url":null,"abstract":"<p><strong>Background: </strong>The growing aging population has led to an increase in the prevalence of Alzheimer's disease (AD) and osteoporosis (OP), both of which significantly impair quality of life. The comorbid nature of these conditions suggests a shared genetic etiology, the understanding of which is crucial for developing targeted therapies.</p><p><strong>Objective: </strong>This study aims to explore the shared genetic etiology underlying AD and OP, using a system biology approach to identify potential therapeutic targets and natural compounds for treatment.</p><p><strong>Methods: </strong>We employed Weighted Gene Co-Expression Network Analysis (WGCNA) with molecular docking strategies to uncover the genetic links between AD and OP. MT2A and CACNA1C were identified as key pleiotropic hub genes potentially linking AD and OP. Molecular docking was utilized to screen for compounds with therapeutic potential, leading to the identification of formononetin as a compound with significant binding affinity to these hub genes. Quantitative real-time PCR (qRT-PCR) validation was conducted to confirm the gene expression changes in disease models.</p><p><strong>Results: </strong>Our study indicate that formononetin exhibits strong binding affinity to the identified hub genes, MT2A and CACNA1C. qRT-PCR validation confirmed the upregulation of these genes in disease models, which was mitigated upon treatment with formononetin, suggesting a reversal of disease markers.</p><p><strong>Conclusions: </strong>This study advances our understanding of the genetic intersections between AD and OP and positions formononetin as a promising natural agent for further translational research. Formononetin's multi-target potential makes it a valuable candidate for managing these comorbid conditions, meriting further investigation and development as a therapeutic strategy.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"361-371"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of visit-to-visit blood pressure variability and time in target range in predicting risk for cognitive outcomes in the SPRINT trial.","authors":"Isabel J Sible, Daniel A Nation","doi":"10.1177/13872877241303378","DOIUrl":"10.1177/13872877241303378","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure (BP) variability (BPV) and time in target range (TTR) are emerging vascular risk factors for dementia, independent of traditionally targeted mean BP.</p><p><strong>Objective: </strong>Determine whether BPV or TTR is most strongly associated with cognitive risk.</p><p><strong>Methods: </strong>In this post hoc analysis of the SPRINT trial, 8034 participants underwent repeated BP measurement and cognitive testing at baseline and follow-up. Visit-to-visit BPV was calculated as average real variability. TTR was the percent of time in desired treatment arm target range (standard: 120-140 mmHg systolic BP; intensive: 110-130 mmHg systolic BP). Adjudicated clinical outcomes were no cognitive impairment, mild cognitive impairment (MCI), and probable dementia. We investigated a direct comparison of BPV and TTR in predicting cognitive risk, stratified by BP treatment group.</p><p><strong>Results: </strong>Elevated BPV was associated with increased risk for MCI (adjusted HR: 1.21 [95% CI 1.10, 1.33], <i>p </i>< 0.001) and MCI/dementia (HR: 1.17 [95% CI 1.07, 1.27], <i>p </i>< 0.001) in the standard group, and dementia (HR: 1.17 [95% CI 1.01, 1.36], <i>p </i>= 0.039) in the intensive group. Higher TTR was related to lower dementia risk (HR: 0.72 [95% CI 0.60, 0.86], <i>p </i>< 0.001) in the intensive group only.</p><p><strong>Conclusions: </strong>Visit-to-visit BPV outperformed TTR in predicting risk for MCI and MCI/dementia. TTR was more strongly associated with dementia risk under intensive treatment. Findings were independent of mean BP in a cohort with rigorously controlled BP and suggest newer aspects of BP control may be harnessed to further reduce cognitive risk.</p><p><strong>Clinical trial information: </strong>ClinicalTrials.gov; NCT01206062.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"396-405"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142836523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articulatory precision from connected speech as a marker of cognitive decline in Alzheimer's disease risk-enriched cohorts.","authors":"Lingfeng Xu, Kewei Chen, Kimberly D Mueller, Julie Liss, Visar Berisha","doi":"10.1177/13872877241300149","DOIUrl":"10.1177/13872877241300149","url":null,"abstract":"<p><strong>Background: </strong>Mild cognitive impairment (MCI) has been recognized as a possible precursor to Alzheimer's disease (AD). Recent research focusing on connected speech has uncovered various features strongly correlated with MCI due to AD and related dementias. Despite these advancements, the impact of early cognitive decline on articulatory precision has not been thoroughly investigated.</p><p><strong>Objective: </strong>This study introduced the phoneme log-likelihood ratio (PLLR) to assess the articulatory precision of speakers across different cognitive status levels and compared its effectiveness to existing well-studied acoustic features.</p><p><strong>Methods: </strong>The study utilized speech recordings from a picture description task, which included data from 324 cognitively unimpaired participants with low amyloid-β burden (CU, Aβ(<math><mo>-</mo></math>)), 47 cognitively unimpaired participants with high amyloid-β burden (CU, Aβ(<math><mo>+</mo></math>)), 69 participants with MCI, and 20 participants with dementia. Nine acoustic features were extracted from the speech recordings, covering three categories: speech fluency, speech pace, and articulatory precision. Welch's <math><mi>t</mi></math>-test and Hedge's <math><mi>g</mi></math> were adopted to assess their discriminative ability.</p><p><strong>Results: </strong>A reduction in speech fluency and pace was observed among participants in the MCI and dementia groups. The PLLR shows large effect sizes in distinguishing between cognitively unimpaired participants with low Aβ burden and those diagnosed with MCI or dementia. Additionally, the test-retest reliability experiment indicated moderate repeatability of the features under study.</p><p><strong>Conclusions: </strong>The study reveals PLLR as a sensitive indicator capable of detecting subtle articulatory variations across groups, while also providing further support for the association between reduced articulatory precision and early cognitive decline.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"476-486"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind's eye in the Alzheimer's disease spectrum continuum.","authors":"Giulia Bechi Gabrielli, Fabrizia D'Antonio, Antonella Di Vita, Roberta Margiotta, Massimiliano Panigutti, Maddalena Boccia, Laura Piccardi, Liana Palermo, Emanuela Salati, Micaela Sepe Monti, Giuseppina Talarico, Giuseppe Bruno, Cecilia Guariglia","doi":"10.1177/13872877241299134","DOIUrl":"10.1177/13872877241299134","url":null,"abstract":"<p><strong>Background: </strong>Visual mental imagery (VMI) is the ability to represent stimuli in the mind without sensory visual input. Previous studies have shown alterations in VMI in Alzheimer's disease (AD). However, VMI has not been investigated in the AD prodromal stage, mild cognitive impairment (MCI).</p><p><strong>Objective: </strong>We investigated VMI ability in mild AD and MCI patients, hypothesizing that VMI ability could be compromised since early disease stage.</p><p><strong>Methods: </strong>We enrolled 14 patients with mild AD, 19 amnestic MCI (aMCI), and 23 healthy control subjects (HC), matched for sex, age, and education. VMI assessment included: 1) the O'clock test that allows disentangling the possible role of visuo-perceptual difficulties in the VMI task's performance; 2) a modified version of The Complete Visual Mental Imagery Battery (CVMIB), including tasks evaluating the different VMI processes (generation, maintenance, inspection and transformation).</p><p><strong>Results: </strong>Results indicated that AD patients performed worse than HC in both perceptual and imaginal tasks of the O'clock test and in all CVMIB's tasks but maintenance. On the contrary, aMCI patients showed difficulties in the generation process and in the imaginal task of the O'clock test.</p><p><strong>Conclusions: </strong>Visual images generation, inspection and transformation processes are impaired in mild AD. Moreover, the generation process is selectively impaired in aMCI patients, suggesting that VMI deficits are already present in the prodromal stage of AD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"194-207"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic light scattering of the eye in the diagnosis of Alzheimer's disease.","authors":"Jeffrey N Weiss","doi":"10.1177/13872877241301802","DOIUrl":"10.1177/13872877241301802","url":null,"abstract":"<p><p>The early detection of Alzheimer's disease, before symptoms have appeared, is integral to the development of effective treatments. Dynamic light scattering spectroscopy measures the Brownian movement of proteins at the molecular level. This technique may facilitate early Alzheimer's disease diagnosis and the discovery of pharmaceuticals that may prevent symptom development.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"349-352"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study.","authors":"Minos Kritikos, Juin-Wan Zhou, Chuan Huang, Sam Gandy, Alison C Pellecchia, Stephanie Santiago-Michels, Melissa A Carr, Shabab Islam, Yuan Yang, Megan K Horton, Roberto G Lucchini, Ana M Franceschi, Lev Bangiyev, Paul Vaska, Sean Ap Clouston, Benjamin J Luft","doi":"10.1177/13872877241302350","DOIUrl":"10.1177/13872877241302350","url":null,"abstract":"<p><strong>Background: </strong>Amyloid-β proteins, a hallmark of Alzheimer's disease, are believed to play an adaptive role in the cerebral immune response.</p><p><strong>Objective: </strong>Amyloid is believed to play a role in cerebral immune response and could play a similar role in response to air pollution exposures. In the present study, we examined whether WTC exposure duration was associated with cerebral amyloidosis in WTC responders.</p><p><strong>Methods: </strong>WTC responders (aged 44-65 years) who varied in exposure duration but did not use personalized protective equipment were assessed using positron-emission tomography with [¹⁸F]-Florbetaben. The outcome was the cortical [¹⁸F]-Florbetaben burden, measured using regional standardized uptake value ratios (SUVRs) in 34 Desikan-Killiany regions of interest. Spearman's <i>ρ</i> and generalized linear models were used to estimate correlations between WTC exposure duration and cortical [¹⁸F]-Florbetaben SUVR. Cognitive and behavioral symptoms were measured. Magnetic resonance imaging was used to measure cortical thickness and diffusivity.</p><p><strong>Results: </strong>The mean age of imaged responders was 56 years old. WTC exposure duration was associated with olfactory [¹⁸F]-Florbetaben SUVR (Spearman's <i>ρ</i> = 0.43, p = 0.011), which was in turn associated with elevated [¹⁸F]-Florbetaben SUVR in ventral regions (<i>ρ</i> = 0.41, p = 0.016). Cortical [¹⁸F]-Florbetaben in ventral regions was associated with reduced response speed (<i>ρ</i> = -0.72, p < 0.001), was co-located with cortical diffusivity across regions in the parietal and frontal lobes and reduced cortical thickness in the isthmus cingulate (<i>ρ</i> = -0.53, p = 0.001).</p><p><strong>Conclusions: </strong>Low-grade amyloidosis in the olfactory and frontal lobes was associated with WTC exposure duration. Future work should examine whether low-grade amyloidosis is correlated with the location or distribution of neurofibrillary tangles in WTC responders.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"383-395"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}