Journal of Alzheimer's Disease最新文献

{"title":"Perceived risk of Alzheimer's disease: Insights into the Black and African American male perspective.","authors":"Lilcelia A Williams, Lauren Terhorst, Ishan C Williams, Elizabeth Skidmore, Jennifer H Lingler","doi":"10.1177/13872877251317151","DOIUrl":"https://doi.org/10.1177/13872877251317151","url":null,"abstract":"<p><strong>Background: </strong>Non-Hispanic Black and African American men are more likely to have Alzheimer's disease (AD) than non-Hispanic White peers. Despite this, little is known about how Black and African American men perceive dementia risk, which is foundational to prevention.</p><p><strong>Objective: </strong>Acknowledging that personal vantage point influences behavior, our study examined Black and African American male perceptions about their anticipated risk for AD.</p><p><strong>Methods: </strong>We conducted a secondary analysis of Black and African American adult male responses to the Recruitment Innovations for Diversity Enhancement electronic survey study. We examined associations between perceived risk of AD and age, education, employment status, household income adequacy, marital status, living status, prior experience with AD, and subjective memory performance using generalized linear models.</p><p><strong>Results: </strong>Respondents (<i>n </i>= 112) were age 18 to 79 years (<i>M </i>= 51.05, <i>SD </i>= 13.44), and 35% reported prior experience with AD through a friend or family member. Respondents' perceived risk of developing AD ranged from 0 to 100% (<i>M </i>= 33.46, <i>SD </i>= 28.29). Spearman rho correlations revealed modest but significant correlations between perceived risk and age (r = 21, p = 0.03) and marital status (r = -0.22 p = 0.02). The best fitting generalized linear model revealed low perceived risk for AD was associated with younger age, income adequacy and being married or living as married (χ<i>²</i>= 8.76, <i>p </i>= 0.03).</p><p><strong>Conclusion: </strong>Selected social determinants of health were associated with perceived risk. Future studies should examine additional social determinants of health (e.g., social and physical environment) and measures of cognitive and physical health to further explore relationships with perceived risk of AD in Black and African American males.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251317151"},"PeriodicalIF":3.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short communication: Evaluating roles of plasma glial fibrillary acidic protein as Alzheimer's disease biomarker in real-world multi-center memory clinics in Thailand.","authors":"Thanapoom Taweephol, Thanakit Pongpitakmetha, Kittithatch Booncharoen, Jedsada Khieukhajee, Watayuth Luechaipanit, Thanaporn Haethaisong, Adipa Chongsuksantikul, Yuttachai Likitjaroen, Poosanu Thanapornsangsuth","doi":"10.1177/13872877251316546","DOIUrl":"https://doi.org/10.1177/13872877251316546","url":null,"abstract":"<p><p>The roles of reactive astrocytes in Alzheimer's disease (AD) and the correlation between plasma glial fibrillary acidic protein (GFAP) and amyloid-β are emerging. Among 133 patients with cognitive complaints from multi-center memory clinics in Thailand, 73 had AD as defined either by cerebrospinal fluid core biomarkers or amyloid PET. Plasma GFAP demonstrated an AUC of 0.74 (95%CI: 0.65-0.83) for detecting AD and showed large effects on identifying AD status with Cohen's d = 0.81 (95%CI 0.44-1.18). LOESS regression illustrated that plasma GFAP increased from the early stages of AD. Plasma GFAP has potential applications across diverse populations.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251316546"},"PeriodicalIF":3.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian network modeling of statistical dependency within cognitive domains and clinical dementia severity ratings for Western and Indian cohorts.","authors":"Wupadrasta Santosh Kumar, Sayali Rajendra Bhutare, Neelam Sinha, Thomas Gregor Issac","doi":"10.1177/13872877251315018","DOIUrl":"https://doi.org/10.1177/13872877251315018","url":null,"abstract":"<p><strong>Background: </strong>Dementia is studied rigorously in the current times, to assess the potential factors that contribute towards its progression, such as demographic factors, geographical background as well as to understand its impact on essential life skills. Alzheimer's disease, the most common form of dementia, is a major focus due to its prevalence and lack of curative treatments.</p><p><strong>Objective: </strong>We aim to study dementia progression across two geographically distinct populations, by analyzing Clinical Dementia Rating (CDR) scores and its domain-specific components, which reflect the decline in essential life skills. This analysis may support clinicians in designing targeted interventions.</p><p><strong>Methods: </strong>This study investigates the statistical dependencies between the CDR and its six defining domain scores across two distinct aging datasets: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Longitudinal Aging Study of India (LASI). We analyzed the dependencies among domain scores and their influence on the global CDR in both datasets using data-driven directed acyclic graphs, within Bayesian network models.</p><p><strong>Results: </strong>Distinct notable similarities and differences in the associations and the edge strengths between the Western and Indian populations were identified. Memory showed similar prominence in contributing towards global CDR, while the incoming edges on memory domain reduced in LASI over ADNI, specifically from the domains, Home and hobbies, and Community affairs.</p><p><strong>Conclusions: </strong>The analysis highlights a stronger dependency of CDR scores on memory functions in both datasets. The results overall elucidate population-specific differences and similarities in dementia progression across diverse demographic contexts.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251315018"},"PeriodicalIF":3.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing loss and the risk of dementia: A longitudinal analysis of the Korean National Health Insurance Service Senior Cohort.","authors":"Jae-Won Jang, Seung-Hwan Lee, Taesu Kim, Eunju Lee, Sang Won Park, Na Young Yeo, Young-Ju Kim","doi":"10.1177/13872877251316805","DOIUrl":"https://doi.org/10.1177/13872877251316805","url":null,"abstract":"<p><strong>Background: </strong>Hearing loss is a potentially modifiable risk factor implicated in dementia, with recent research suggesting an association between age-related hearing degradation and dementia.</p><p><strong>Objective: </strong>This study aims to elucidate the relationship between hearing decline and dementia risk.</p><p><strong>Methods: </strong>We analyzed data from 511,953 subjects from the Korean National Health Insurance Service-Senior Cohort (2002-2008). After excluding those diagnosed with dementia in 2002, 511,935 subjects were included. Subjects with hearing loss between 2002 and 2008 were selected and matched with a control group without hearing impairment based on age and gender. Statistical analyses, including Pearson's chi-squared test and the Cox proportional hazards model, were conducted, controlling for confounding variables such as household income and residential area. Subgroup analysis was also performed for Alzheimer's disease and vascular dementia.</p><p><strong>Results: </strong>Subjects with hearing loss had a 1.245 times higher risk of all-cause dementia compared to those without hearing loss (adjusted hazard ratio over 3 years, 95% CI = 1.201-1.290), adjusting for gender, age, residence, and income. The adjusted hazard ratios for Alzheimer's disease over 3, 5, 7, and 10 years from the index date were 1.259 (95% CI = 1.211-1.308), 1.258 (95% CI = 1.208-1.310), 1.269 (95% CI = 1.215-1.325), and 1.235 (95% CI = 1.170-1.304), respectively. No significant association was found for vascular dementia, except for 3 years.</p><p><strong>Conclusions: </strong>Hearing loss consistently increased the risk of all-cause dementia and Alzheimer's disease across timespans, suggesting a complex link between hearing loss and neurodegenerative diseases. These findings highlight the importance of early intervention and cognitive monitoring for individuals with hearing loss.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251316805"},"PeriodicalIF":3.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-penetrant histone deacetylase inhibitor RG2833 improves spatial memory in females of an Alzheimer's disease rat model.","authors":"Kelechi Ndukwe, Peter A Serrano, Patricia Rockwell, Lei Xie, Maria E Figueiredo-Pereira","doi":"10.1177/13872877251314777","DOIUrl":"10.1177/13872877251314777","url":null,"abstract":"<p><strong>Background: </strong>Nearly two-thirds of Alzheimer's disease (AD) patients are women. Therapeutics for women are critical to lowering their elevated risk of developing this major cause of adult dementia. Moreover, targeting epigenetic processes such as histone acetylation that regulate multiple cellular pathways is advantageous given the multifactorial nature of AD. Histone acetylation takes part in memory consolidation, and its disruption is linked to AD.</p><p><strong>Objective: </strong>Determine whether the investigational drug RG2833 has repurposing potential for AD. RG2833 is a histone deacetylase HDAC1/3 inhibitor that is orally bioavailable and permeates the blood-brain-barrier.</p><p><strong>Methods: </strong>RG2833 effects were determined on cognition, transcriptome, and AD-like pathology in 11-month TgF344-AD female and male rats. Treatment started early in the course of pathology when therapeutic intervention is predicted to be most effective.</p><p><strong>Results: </strong>RG2833-treatment of 11-month TgF344-AD rats: (1) Significantly improved hippocampal-dependent spatial memory in females but not males. (2) Upregulated expression of immediate early genes, such as Arc, Egr1 and c-Fos, and other genes involved in synaptic plasticity and memory consolidation in females. Remarkably, out of 17,168 genes analyzed for each sex, no significant changes in gene expression were detected in males at p < 0.05, false discovery rate <0.05, and fold-change equal or > 1.5. (3) Failed to improve amyloid beta accumulation and microgliosis in female and male TgF344-AD rats.</p><p><strong>Conclusions: </strong>Our study highlights the potential of histone-modifying therapeutics such as RG2833 to improve cognitive behavior and drive the expression of immediate early, synaptic plasticity and memory consolidation genes, especially in female AD patients.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251314777"},"PeriodicalIF":3.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to intervention components: The key to success? Analysis on health-related outcomes of the AgeWell.de intervention to preserve cognition.","authors":"Felix G Wittmann, Alexander Pabst, Andrea Zülke, Melanie Luppa, Maria I Cardona, Melanie Boekholt, Thomas Fankhänel, Solveig Weise, Robert Philipp Kosilek, Linda Sanftenberg, Christian Brettschneider, Juliane Döhring, Martin Williamson, Birgitt Wiese, Jochen René Thyrian, Wolfgang Hoffmann, Jochen Gensichen, Hans-Helmut König, Hanna Kaduszkiewicz, Thomas Frese, Steffi G Riedel-Heller","doi":"10.1177/13872877251314892","DOIUrl":"https://doi.org/10.1177/13872877251314892","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to analyze the impact of adherence to the intervention components on the effectiveness of AgeWell.de, a multi-domain lifestyle intervention against cognitive decline, on function in everyday activities, quality of life, depressiveness and social isolation.</p><p><strong>Objective: </strong>Studying the effect of adherence on health-related outcomes.</p><p><strong>Methods: </strong>Participants were aged 60-77 years at baseline and at risk (Cardiovascular Risk Factors, Ageing and Dementia Score (CAIDE) ≥9). Adherence to the components nutrition, enhancement of physical and social activities and cognitive training was analyzed in two ways, first continual within the intervention group (n = 378, mean age = 69.1 years, 52.7% female) and second as dichotomous split (75% adherence) and in reference to the control group (received infomaterial and regular health advice; n = 441, mean age = 69 years, 53% female). Generalized linear regression models were then run on the health outcomes functioning in everyday activities, quality of life, depressive symptoms, and social inclusion.</p><p><strong>Results: </strong>Health-related quality of life and depressiveness were improved in participants with better adherence to nutritional counselling and enhancement of physical and social activities. Better adherence to social activities was relevant for function in everyday activities. Effects of high adherence to cognitive training was found for improvements in depressiveness when comparing it to the control group. No effect was found on social inclusion when considering the particular components.</p><p><strong>Conclusions: </strong>The extent of adherence to most components influenced health-related outcomes such as health-related quality of life and depressiveness. With this study, the effectiveness of AgeWell.de can be understood in greater depth.</p><p><strong>Trial registration: </strong>German Clinical Trial Register (DRKS; ID: DRKS00013555).</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251314892"},"PeriodicalIF":3.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of acupuncture as a complementary treatment for Alzheimer's disease: Pushing the boundaries forward.","authors":"Rhuann Pontes Dos Santos Silva, Breno José Alencar Pires Barbosa","doi":"10.1177/13872877251316572","DOIUrl":"https://doi.org/10.1177/13872877251316572","url":null,"abstract":"<p><p>Acupuncture has emerged as a promising adjunctive symptomatic therapy for Alzheimer's disease, demonstrating potential benefits in cognitive function and neuroprotection. Recent meta-analyses and randomized clinical trials have investigated the potential of acupuncture to improve cognitive assessments, signaling pathways, and gut regulation in Alzheimer's disease, underscoring its potential clinical application. However, the limited number of studies, small sample sizes, and lack of detailed mapping of acupuncture's core targets must be considered when interpreting these positive results.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251316572"},"PeriodicalIF":3.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of whole-head 810 nm near-infrared therapy on cognitive and neuropsychiatric symptoms in Alzheimer's disease: A pilot study.","authors":"Rong Guo, Deyu Li, Fang Li, Linna Ji, Hongying Liu, Huiting Qiao, Zeping Lv, Yi Tang, Daifa Wang","doi":"10.1177/13872877251313819","DOIUrl":"https://doi.org/10.1177/13872877251313819","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by significant cognitive and behavioral impairments. Near-infrared (NIR) light treatment has shown potential in cognitive improvement in previous studies. However, clinical trials of NIR for AD remain limited.</p><p><strong>Objective: </strong>This study investigated the safety and effects of whole-head 810 nm NIR therapy in AD patients, including long-term efficacy.</p><p><strong>Methods: </strong>An open-label pilot study on whole-head NIR treatment for AD patients was conducted. Nine AD patients completed 4-month treatment (810 nm, 100 mW/cm², 30 min/session, 6 sessions weekly). Safety and efficacy were evaluated at baseline, months 2 and 4, and 2-month post-treatment.</p><p><strong>Results: </strong>After four months of whole-head NIR treatment, mean changes from baseline on the Mini-Mental State Examination were 3.2 (<i>p </i>= 0.02). Mean changes from baseline on the Alzheimer's Disease Assessment Scale-Cognitive were -5.0 (<i>p </i>= 0.05), mean changes from baseline on the Montreal Cognitive Assessment were 1.9 (<i>p </i>= 0.12). Mean changes from baseline on the Neuropsychiatric Inventory were -4.2 (<i>p </i>= 0.47). These benefits were sustained two months at least. With no device-related adverse effects were reported.</p><p><strong>Conclusions: </strong>Whole-head 810 nm NIR light is safe and offers promising benefits for AD patients. To fully confirm its efficacy, durability, and underlying mechanisms, further large-scale randomized controlled trials are necessary.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251313819"},"PeriodicalIF":3.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal and concurrent C-reactive protein and diet associations with cognitive function in the population-based Tromsø study.","authors":"Olena Iakunchykova, Henrik Schirmer, James M Roe, Øystein Sørensen, Tom Wilsgaard, Laila A Hopstock, Anne Elise Eggen, Michael E Benros, Chi-Hua Chen, Yunpeng Wang","doi":"10.1177/13872877251317624","DOIUrl":"https://doi.org/10.1177/13872877251317624","url":null,"abstract":"<p><strong>Background: </strong>Immune dysregulation has been implicated in Alzheimer's disease; however, precise mechanisms and timing have not been established.</p><p><strong>Objective: </strong>To investigate the concurrent and longitudinal associations of serum C-reactive protein (CRP) and dietary inflammatory index (DII) with cognitive decline as observed in Alzheimer's disease.</p><p><strong>Methods: </strong>The study was based on 7613 individuals who participated in Tromsø6 (2007-2008) and Tromsø7 (2015-2016). We analyzed the relationship between CRP levels, DII, and cognitive function cross-sectionally using linear regression. We used mediation analysis to examine if CRP mediates the effects of DII on cognitive function. Further, we related baseline serum CRP to cognitive function and to change in cognitive function after 7 years of follow up. We used linear mixed models to relate changes in CRP levels to changes in cognitive function measured at two time points with 7 years apart.</p><p><strong>Results: </strong>Both CRP level and DII were cross-sectionally inversely associated with cognitive function (psychomotor speed, executive function). There was no prospective relationship between CRP level at baseline and cognitive function after 7 years of follow up. Increase in CRP levels was associated with decrease in cognitive function (psychomotor speed, executive function, and verbal memory) observed between two measurements 7 years apart. The mediation model did not show convincing evidence of a mediating effect of CRP in the association between diet and cognitive function.</p><p><strong>Conclusions: </strong>After comprehensive analysis of associations between CRP, DII and cognitive function, we conclude that CRP is likely to reflect the changes in inflammatory environment occurring in parallel with cognitive decline.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251317624"},"PeriodicalIF":3.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglial polarization in Alzheimer's disease: Mechanisms, implications, and therapeutic opportunities.","authors":"Xinmao Yang, Jie Wang, Xiaotao Jia, Yaqian Yang, Yan Fang, Xiaoping Ying, Hong Li, Meiqian Zhang, Jing Wei, Yanfang Pan","doi":"10.1177/13872877241313223","DOIUrl":"https://doi.org/10.1177/13872877241313223","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, neurofibrillary tangles, and chronic neuroinflammation. Microglial cells, the resident immune cells in the central nervous system, play a crucial role in the pathogenesis of AD. Microglia can undergo polarization, shifting between pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes in response to different stimuli. Dysregulation of microglial polarization towards the pro-inflammatory phenotype leads to the release of inflammatory cytokines, oxidative stress, and synaptic dysfunction. These processes contribute to neuronal damage and cognitive decline in AD. However, several challenges remain in this field. The complex molecular mechanisms governing microglial polarization in AD need to be further elucidated. In this review, we discuss the mechanisms underlying microglial polarization in AD and its implications in disease progression.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877241313223"},"PeriodicalIF":3.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}