非认知症状和事件的纵向在线每周报告可以区分偶发性轻度认知障碍和稳定的认知健康老年人。

IF 3.1 3区 医学 Q2 NEUROSCIENCES
Christine McClure, Nora Mattek, Zachary Beattie, Nicole Sharma, Thomas Riley, Joel Steele, Jeffrey Kaye
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引用次数: 0

摘要

背景:老年人情绪、孤独、疼痛和需要帮助等非认知症状的变化可能是轻度认知障碍(MCI)和阿尔茨海默病及相关疾病(ADRD)的潜在早期标志。这些变化可能是微妙的和波动的,因此很容易错过间歇性门诊就诊。目的探讨自我感知的内在状态和需求变化与认知功能障碍发展的关系。研究人员对参与俄勒冈生命实验室的老年人进行了长达2.9年的与MCI相关的健康相关活动和情绪的每周在线报告评估,该研究使用基于家庭的身体、认知、行为、生理和健康相关活动的不干扰遥感。结果分析样本包括129名认知健康志愿者,平均随访2.9±1.2年。平均年龄83.5±7.8岁,平均文化程度15.7±2.7岁,女性占76%。22名参与者(17%)发展为轻度认知障碍或痴呆,而107名参与者保持认知健康。随着时间的推移,与认知健康的参与者相比,更多的MCI参与者报告:(1)孤独(p = 0.049),(2)情绪低落(p = 0.08),(3)疼痛强度(p = 0.03)和疼痛干扰(p = 0.01),以及(4)需要家庭帮助(p = 0.02)。评估这些症状的基线评分在临床上没有相关性,不能预测轻度认知损伤,组间也没有显著差异。结论基于家庭的非认知功能或内部状态(孤独、情绪、疼痛、需要更多帮助)的纵向在线评估可以作为导致MCI和ADRD的脑功能变化的敏感早期指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Longitudinal online weekly reports of non-cognitive symptoms and events can differentiate incident mild cognitive impairment from stable cognitively healthy older adults.

BackgroundChanges in noncognitive symptoms such as mood, loneliness, pain, and need for assistance may be potential early markers of mild cognitive impairment (MCI) and Alzheimer's disease and related disorders (ADRD) in older adults. These changes can be subtle and fluctuating, and thus easily missed during intermittent clinic visits.ObjectiveTo assess the relationship of changes in self-perceived internal states and needs to the development of cognitive impairment over time.MethodsWeekly online reports of health-related activities and mood in relation to MCI were assessed for up to 2.9 years in older adults participating in the Oregon Life Laboratory, a study using home-based unobtrusive remote sensing of physical, cognitive, behavioral, physiological, and health-related activities.ResultsThe analytic sample included 129 cognitively healthy volunteers followed for a mean of 2.9 ± 1.2 years. Mean age was 83.5 ± 7.8 years, mean education was 15.7 ± 2.7 years, and 76% were female. Twenty-two participants (17%) developed MCI or dementia while 107 remained cognitively healthy. Over time, more of the participants destined to develop MCI reported: (1) loneliness (p = 0.049), (2) low mood (p = 0.08), (3) pain intensity (p = 0.03) and pain interference (p = 0.01), and (4) needing in-home assistance (p = 0.02) than those remaining cognitively healthy. Baseline scores assessing these symptoms were not clinically concerning, predictive of MCI, nor significantly different between groups.ConclusionsLongitudinal home-based online assessment of non-cognitive aspects of function or internal states (loneliness, mood, pain, needing more assistance) can be sensitive early indicators of changes in brain function leading to MCI and ADRD.

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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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