Journal of Alzheimer's Disease最新文献_第6页

Associations of metabolic syndrome with risks of dementia and cognitive impairment: A systematic review and meta-analysis. 代谢综合征与痴呆症和认知障碍风险的关系：系统回顾和荟萃分析。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 Epub Date: 2025-03-20 DOI: 10.1177/13872877251326553

Shu-Dong Qiu, Dan-Dan Zhang, Li-Yun Ma, Qiong-Yao Li, Lan-Yang Wang, Yu-Dong Wang, Yong-Chang Wang, Shi-Yin Xiong, Lan Tan

{"title":"Associations of metabolic syndrome with risks of dementia and cognitive impairment: A systematic review and meta-analysis.","authors":"Shu-Dong Qiu, Dan-Dan Zhang, Li-Yun Ma, Qiong-Yao Li, Lan-Yang Wang, Yu-Dong Wang, Yong-Chang Wang, Shi-Yin Xiong, Lan Tan","doi":"10.1177/13872877251326553","DOIUrl":"10.1177/13872877251326553","url":null,"abstract":"BackgroundPrevious studies have linked metabolic syndrome (MetS) to dementia risk.ObjectiveWe conducted a systematic review and meta-analysis to assess the association between MetS and dementia as well as cognitive impairment, with additional focus on individual MetS components.MethodsWe systematically searched the PubMed, Embase, and Cochrane Library databases from inception through July 2024. We used random-effects models to calculate relative risks (RRs) and odds ratios (ORs) with 95% confidence intervals (CIs). Publication bias was evaluated using the Egger's test, while potential sources of heterogeneity were investigated through meta-regression, subgroup, and sensitivity analyses.ResultsOur analysis included 21 studies with a total of 411,810 participants. MetS was associated with increased risks of all-cause dementia (RR = 1.33, 95% CI = 1.03-1.71, I² = 85.8%) and vascular dementia (RR = 2.07, 95% CI = 1.32-3.24, I² = 10.1%), but not Alzheimer's disease (RR = 1.10, 95% CI = 0.64-1.91, I² = 81.8%). Regarding cognitive impairment, longitudinal studies showed an increased risk (OR = 1.38, 95% CI = 1.24-1.53, I² = 3.3%), with similar findings in cross-sectional studies (OR = 1.65, 95% CI = 1.19-2.28, I² = 85.3%).ConclusionsThis study found that MetS is significantly associated with increased risks of dementia and cognitive impairment, with each component potentially being a modifiable factor. These findings may help guide clinicians in recommending lifestyle interventions to prevent cognitive decline and promote brain health.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"15-27"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donanemab eligibility in early Alzheimer's disease: A real-world study. Donanemab在早期阿尔茨海默病中的适用性：一项真实世界的研究。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 DOI: 10.1177/13872877251331243

Daniele Urso, Alessandro Introna, Valentina Gnoni, Alessia Giugno, Davide Vilella, Chiara Zecca, Roberto De Blasi, Stefano Giannoni-Luza, Giancarlo Logroscino

引用次数: 0

Sharing patient technology preferences with care networks: Stakeholders' views of the "Let's Talk Tech" decision aid for dementia care. 与护理网络分享患者技术偏好：利益相关者对痴呆症护理“Let’s Talk Tech”决策援助的看法。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 DOI: 10.1177/13872877251332659

Clara Berridge, Natalie R Turner, William B Lober, George Demiris, Jeffrey Kaye

{"title":"Sharing patient technology preferences with care networks: Stakeholders' views of the \"Let's Talk Tech\" decision aid for dementia care.","authors":"Clara Berridge, Natalie R Turner, William B Lober, George Demiris, Jeffrey Kaye","doi":"10.1177/13872877251332659","DOIUrl":"https://doi.org/10.1177/13872877251332659","url":null,"abstract":"BackgroundLet's Talk Tech (LTT) is a self-administered web intervention for people with memory loss and their care partners that supports decision-making about digital health technologies. In past work, dyads wanted to share LTT preference reports with their larger care networks.ObjectiveThis study aims to understand with whom care dyads want to share their technology preference reports and why, and if and how clinicians want to receive them.MethodsTogether, fifteen dyads of people living with mild cognitive impairment (MCI) or early-stage dementia (n = 15) and a care partner (n = 15) completed LTT and two survey questions. Care partners completed independent follow-up interviews, and 32 clinicians at four Alzheimer's Disease Research Center-affiliated clinics viewed an LTT report and completed a 10-question survey. We used descriptive statistics for survey responses and thematic analysis for interviews.ResultsTwo-thirds of care partners (n = 10) wanted to share the report with family members. Half (n = 8) wanted to share it with clinicians to keep them informed about the dyad's planning and facilitate conversations about technology options. 30 of 32 clinicians reported they would want their patients' technology preferences reports, with 25 wanting to access it via the electronic health record (EHR).ConclusionsFindings demonstrate potential value to both family dyads and providers of sharing technology preferences beyond the care dyad. Clinicians were highly receptive to accessing technology preference reports in EHRs and to having discussions about technology be a part of advance care planning. Future research should test integration in the EHR and the potential of sharing technology preferences to support person-centered technology choices.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251332659"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validate association of gene loci and establish genetic risk prediction models for late-onset Alzheimer's disease in Chinese populations. 验证基因位点的相关性，建立中国人群迟发性阿尔茨海默病的遗传风险预测模型。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.1177/13872877251326283

Fangyu Li, Menghan Zheng, Jianping Jia

{"title":"Validate association of gene loci and establish genetic risk prediction models for late-onset Alzheimer's disease in Chinese populations.","authors":"Fangyu Li, Menghan Zheng, Jianping Jia","doi":"10.1177/13872877251326283","DOIUrl":"10.1177/13872877251326283","url":null,"abstract":"BackgroundMore than 60 independent single-nucleotide polymorphisms (SNPs) have been associated with Alzheimer's disease risk by genome-wide association studies in European.ObjectiveWe aimed to confirm these SNPs in Chinese Han populations and investigate the utility of these genetic markers.MethodsAltogether 1595 late-onset Alzheimer's disease (LOAD) patients and 2474 controls from Chinese population were recruited. We replicated the association of 68 SNPs with LOAD and established polygenetic risk score (PRS) prediction model using significant SNPs. Meta-analysis for MS4A6A rs610932 and PICALM rs3851179 were performed.ResultsAccording to our findings, 14 out of 68 SNPs are validated significantly associated with LOAD (adjusted p < 0.05) after adjusting age and sex in the Chinese population. Besides, after stratification by APOE ε4 status, almost all SNPs retain markedly relationship with LOAD in APOE ε4 noncarriers. However, few loci retain correlation in APOE ε4 carriers. Furthermore, the area under the receiver operating characteristic curve prediction model for distinguishing LOAD patients from normal subjects were 0.614 for PRS and 0.689 for PRS and APOE. In addition, meta-analysis including this study of East Asian populations confirmed that rs610932 and rs3851179 were dramatically related to the LOAD (OR = 0.85, 95% CI = 0.74-0.97; OR = 0.87, 95% CI = 0.83-0.91).ConclusionsDespite genetic heterogeneity, there are still common loci among different races. PRS based on AD risk-associated SNPs may supplement APOE for better assessing individual risk for AD in Chinese. Besides, interactions between genes and gene environment affect the impact of risk allele on diverse populations.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"205-215"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A polymorphism in the BIN1 gene influences its expression and is associated with the risk of Alzheimer's disease: An integrated analysis. BIN1基因的多态性影响其表达并与阿尔茨海默病的风险相关：一项综合分析

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.1177/13872877251326273

Shitao Wang, Guoshuai Luo, Guangxin Sun, Mengen Zhang, Yaqin Qin, Jinghong Lu, Hui Xu, Zongyou Li

{"title":"A polymorphism in the BIN1 gene influences its expression and is associated with the risk of Alzheimer's disease: An integrated analysis.","authors":"Shitao Wang, Guoshuai Luo, Guangxin Sun, Mengen Zhang, Yaqin Qin, Jinghong Lu, Hui Xu, Zongyou Li","doi":"10.1177/13872877251326273","DOIUrl":"10.1177/13872877251326273","url":null,"abstract":"BackgroundThe correlation between rs7561528 and the risk of Alzheimer's disease (AD) has been reported with varying results, and the potential mechanism of rs7561528 in influencing AD risk remains unexplored.ObjectiveThis study aims to examine the impact of rs7561528 on AD risk and to investigate its potential mechanism.MethodsThis study initially synthesized previously published data to investigate the correlation between rs7561528 and AD risk. Subsequently, an expression quantitative trait loci analysis was conducted to determine whether rs7561528 modulates the expression of BIN1 in human brain tissue.ResultsOur findings revealed that the rs7561528A allele notably escalates the risk of AD in the Caucasian population (OR = 1.17, 95% CI = 1.07-1.28, I² = 33.5%). Similarly, the rs7561528AG genotype also significantly heightens the risk of AD in the same population (OR = 1.18, 95% CI = 1.05-1.31, I² = 21.7%). Further analysis demonstrated that the combined rs7561528AA + AG genotype substantially amplifies the risk of AD in the Caucasian population (OR = 1.21, 95% CI = 1.08-1.36, I² = 30.0%). Ultimately, we discovered that rs7561528 modulates the expression of BIN1 in human brain tissue.Conclusionsrs7561528 could potentially affect the risk of AD by regulating the expression levels of BIN1 in human brain tissue. This discovery enhances our understanding of novel mechanisms through which rs7561528 may contribute to AD risk.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"197-204"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social functioning in individuals with Alzheimer's disease and the situation of caregivers. 阿尔茨海默病患者的社会功能和照顾者的情况。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.1177/13872877251326029

Sophia Kraake, Melanie Luppa, Dorothee Saur, Jens Dietzel, Jan-Philipp Bach, Steffi G Riedel-Heller, Janine Stein

{"title":"Social functioning in individuals with Alzheimer's disease and the situation of caregivers.","authors":"Sophia Kraake, Melanie Luppa, Dorothee Saur, Jens Dietzel, Jan-Philipp Bach, Steffi G Riedel-Heller, Janine Stein","doi":"10.1177/13872877251326029","DOIUrl":"10.1177/13872877251326029","url":null,"abstract":"BackgroundChanges in social functioning may be a significant parameter for the early detection of Alzheimer's disease (AD). Currently, research on social functioning in AD across the entire spectrum of the disease is lacking.ObjectiveThe aim of this study was to describe the social functioning of persons with AD at each stage of the disease and to investigate how impaired social functioning affects caregiver burden.MethodsCross-sectional data was derived from memory clinics across Germany as part of the pilot study \"Social functioning in individuals with AD and the situation of caregivers\". A total of N = 87 relatives providing care for individuals with mild (n = 20), moderate (n = 40), and severe (n = 23) AD were included. Social functioning of individuals with AD was measured via the caregiver-rated German version of the Social Functioning in Dementia Scale (SF-DEM); caregiver burden was assessed using the Zarit Caregiver Burden Interview (ZBI-12). Differences between mild, moderate, and severe AD in terms of sociodemographic characteristics and the level of social functioning were examined. A robust linear regression analysis was conducted to examine the association between social functioning and caregiver burden.ResultsSocial functioning was lower in moderate and severe AD than in mild AD. Higher levels of social functioning were associated with less caregiver burden.ConclusionsThis study highlights the importance of integrating social functioning assessments into clinical practice for improving the early detection, diagnosis and interventions for AD. Early interventions to enhance social functioning may diminish caregiver burden.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"77-89"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of anti-seizure medications on Alzheimer's disease (AD) risk and AD-related symptoms: A scoping review. 抗癫痫药物对阿尔茨海默病（AD）风险和AD相关症状的影响：范围综述

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.1177/13872877251324663

Jonathan P Williams, Yiqi Zhu, Ramkrishna K Singh, Kebede Beyene, Rohan Rani, Xian Kapetanakos, Amanda Dias, Katherine McGuire, Ramana Kolady, Kim Lipsey, Sridharan Gopalsamy Ramaswamy, Vishnuvardhan Thotakura, Jean-Francois Trani, Ganesh M Babulal

{"title":"The effect of anti-seizure medications on Alzheimer's disease (AD) risk and AD-related symptoms: A scoping review.","authors":"Jonathan P Williams, Yiqi Zhu, Ramkrishna K Singh, Kebede Beyene, Rohan Rani, Xian Kapetanakos, Amanda Dias, Katherine McGuire, Ramana Kolady, Kim Lipsey, Sridharan Gopalsamy Ramaswamy, Vishnuvardhan Thotakura, Jean-Francois Trani, Ganesh M Babulal","doi":"10.1177/13872877251324663","DOIUrl":"10.1177/13872877251324663","url":null,"abstract":"BackgroundAs the fastest-growing segment of the population, adults over 65 are at the most significant risk for Alzheimer's disease (AD). Older adults often use anti-seizure medications (ASMs), which can negatively impact cognitive function, mood, and behavior, mimicking AD or its symptoms. Understanding the effects of ASMs across diverse older adults is crucial, given that some ethnoracial groups are at higher risk for AD or more severe symptoms compared to non-Hispanic Whites.ObjectiveTo summarize the current evidence on the association of ASMs with AD risk and AD-related symptoms and explore the inclusion of ethnoracial minority groups in these studies.MethodsData sources included PubMed/MEDLINE, EMBASE, and SCOPUS for English-language studies published between 1990-2024. Selected studies were peer-reviewed, cross-sectional, longitudinal, case-control, and clinical trials on AD dementia or related symptoms and ASMs. Study quality was rated by the Oxford Centre for Evidence-Based Research Medicine.ResultsA total of 27 studies with 1,241,796 participants were included. Data on AD risk from level IB-IIIB evidence studies showed mixed results, with some indicating an increased association with ASM use [OR = 1.05-1.16, 95% CI: 1.01-1.24]. Studies on AD-related symptoms from level IB-IV evidence also showed mixed results. Only three North American studies explicitly included race/ethnicity; most were conducted in European countries.ConclusionsASM use may be modestly associated with an increased risk of AD among the older adult population, but current data are inconclusive. The association of ASMs on AD-related symptoms varied. Future studies should emphasize reporting sociodemographic data and include diverse cohorts to enhance the applicability of findings.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"3-14"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-year exercise improves cognition and fitness and decreases vascular stiffness and reactivity to CO2 in amnestic mild cognitive impairment. 一年的锻炼可以改善健忘轻度认知障碍患者的认知和健康状况，降低血管僵硬度和对二氧化碳的反应性。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1177/13872877251325575

Suhaas Penukonda, Srivats Srinivasan, Takashi Tarumi, Tsubasa Tomoto, Min Sheng, C Munro Cullum, Rong Zhang, Hanzhang Lu, Binu P Thomas

{"title":"One-year exercise improves cognition and fitness and decreases vascular stiffness and reactivity to CO2 in amnestic mild cognitive impairment.","authors":"Suhaas Penukonda, Srivats Srinivasan, Takashi Tarumi, Tsubasa Tomoto, Min Sheng, C Munro Cullum, Rong Zhang, Hanzhang Lu, Binu P Thomas","doi":"10.1177/13872877251325575","DOIUrl":"10.1177/13872877251325575","url":null,"abstract":"BackgroundAmnestic mild cognitive impairment (aMCI) is often a precursor stage to Alzheimer's disease (AD). Aerobic exercise (AE) has received increasing attention in the prevention of AD. While there is some evidence that it improves neurocognitive function in older individuals, the effect of exercise in the long-term is not well understood.ObjectiveTo assess the effect of long-term exercise on cognition, fitness, vascular stiffness, and cerebrovascular reactivity (CVR).MethodsIn this prospective clinical trial, 27 aMCI participants were enrolled into two groups and underwent 12 months of intervention. One group (n = 11) underwent AE training (6M/5F, age = 66.2 years), and the control group (n = 16) performed stretch training (ST group, 9M/7F, age = 66.4 years). Both groups performed training three times per week with duration and intensity gradually increased over time. CVR was measured at pre- and post-training using blood-oxygenation-level-dependent MRI.ResultsIn the AE group, aerobic fitness improved (p = 0.034) and carotid artery stiffness decreased (p = 0.005), which was not observed in the ST group. In all participants, decreases in carotid artery stiffness were associated with increases in aerobic fitness (p = 0.043). The AE group displayed decreases in CVR in the anterior cingulate cortex and middle frontal gyrus (p < 0.05, FWE corrected); the ST group did not show significant changes in CVR. Several measures of cognition (i.e., inhibition and delayed recall), neuropsychiatric symptoms, and functional status ratings improved only in the AE group.ConclusionsThese results suggest that AE may alter cerebral hemodynamics in patients with aMCI which may improve cognitive, psychological, and functional status.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"245-257"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of glycoprotein 1b and miR-26a-5p levels with platelet function in Alzheimer's disease. 糖蛋白1b和miR-26a-5p水平与阿尔茨海默病血小板功能的关系

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 Epub Date: 2025-03-20 DOI: 10.1177/13872877251326204

Gülsel Ayaz, Pelin Sordu, Umut Can Küçüksezer, Haşmet Hanağası, Merve Alaylıoğlu, Hakan Gürvit, Duygu Gezen-Ak, Başar Bilgiç, Erdinç Dursun, Turgut Ulutin

{"title":"Association of glycoprotein 1b and miR-26a-5p levels with platelet function in Alzheimer's disease.","authors":"Gülsel Ayaz, Pelin Sordu, Umut Can Küçüksezer, Haşmet Hanağası, Merve Alaylıoğlu, Hakan Gürvit, Duygu Gezen-Ak, Başar Bilgiç, Erdinç Dursun, Turgut Ulutin","doi":"10.1177/13872877251326204","DOIUrl":"10.1177/13872877251326204","url":null,"abstract":"BackgroundAlterations in biochemical and molecular pathways in Alzheimer's disease (AD) may be evident in the brain, blood cells, and vessels. Platelets regulate blood hemostasis and play key roles in neurodegenerative diseases like AD. miR-26a-5p and GP1b may affect platelet functions (PF), with miR-26a-5p as a diagnostic/therapeutic target and GP1b linking vascular and neurological disorders in AD progression.ObjectiveThis study explores the roles of GP1b and hsa-miR-26a-5p in regulating PF in AD.Methods85 participants, including 43 AD, and 45 controls, were included. PF induced by ADP were assessed by optical density and white matter changes by MRI Axial FLAIR. Serum levels of von Willebrand Factor and GP1b were measured by ELISA. Platelet receptor expressions of CD62P and CD42b (GPIb) were measured by flow cytometry, and levels of hsa-miR-26a-5p and hsa-miR-24-3p by qRT-PCR.ResultsADP-induced PF was significantly reduced in AD (p = 0.016). Flow cytometry showed significantly low CD42b and high CD62P expression in AD, respectively (p < 0.0001, p = 0.014). Serum GP1b levels were significantly higher in AD (p = 0.018). Additionally, hsa-miR-26a-5p expression was significantly low in AD (p = 0.001), and a positive correlation was found between the expression levels of hsa-miR-24-3p and hsa-miR-26a-5p in both controls; and AD (r = 0.4149, p = 0.0051, 95% CI = 0.1256-0.6392; r = 0.6820, p = 0.0023, 95% CI 0.4728-0.8184).ConclusionsThis study highlights increased serum GP1b levels with decreased both platelet surface GP1b levels and hsa-miR-26a-5p expressions in AD. GP1b and hsa-miR-26a-5p might have essential roles on PF in AD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"172-185"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A preliminary study on plasma markers across cognitive stages and links to a history of mild traumatic brain injury. 关于各认知阶段血浆标志物及其与轻度脑外伤病史关系的初步研究。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.1177/13872877251325757

Christian LoBue, Barbara E Stopschinski, Nil Saez Calveras, Amber Salter, Doug Galasko, Chris Giza, C Munro Cullum, Peter M Douglas, John Hart

引用次数: 0