Journal of Alzheimer's Disease最新文献

{"title":"Identification of NDUFV2, NDUFS7, OPA1, and NDUFA1 as biomarkers for Alzheimer's disease: Insights from oxidative stress and mitochondrial dysfunction in the hippocampus.","authors":"Junshi Zhang, Tingting Liu, Haojie Wu, Jianshe Wei, Qiumin Qu","doi":"10.1177/13872877251339771","DOIUrl":"https://doi.org/10.1177/13872877251339771","url":null,"abstract":"<p><p>BackgroundAlzheimer's disease (AD) is characterized by amyloid-β deposits, neurofibrillary tangles, and hippocampal neurodegeneration, with oxidative stress and mitochondrial dysfunction playing critical roles in its pathogenesis. Identifying hub genes associated with these processes could advance biomarker discovery and therapeutic strategies.ObjectiveThis study aimed to identify key oxidative stress- and mitochondrial dysfunction-related genes in the AD hippocampus, evaluate their diagnostic potential, and explore therapeutic agents targeting these genes.MethodsWe analyzed datasets GSE48350 and GSE5281, encompassing 56 controls and 29 AD patients. Weighted gene co-expression network analysis (WGCNA) selected genes with significance (adjusted <i>p</i>-value < 0.05 and |logFC| ≥ 0.5). Further studies involved immune cell infiltration, Gene set enrichment analysis (GSEA), and intersecting differentially expressed genes (DEGs) with oxidative stress-related genes (ORGs) and mitochondrial dysfunction-related genes (MDRGs). Functional enrichment and Protein-protein interaction (PPI) analyses were conducted. Experimental validation was done in AD mouse models, and diagnostic potential was tested using datasets GSE28146 and GSE29652. Therapeutic drugs were predicted based on hub genes.ResultsAD showed altered immune cell expression. GSEA linked DEGs to nervous system processes and neurotransmitters. 194 oxidative stress-related DEGs were enriched in neuronal death and mitochondrial processes. PPI analysis identified 24 DEGs related to both oxidative stress and mitochondrial dysfunction (DEO-MDRGs), with diagnostic potential (AUC > 0.5). LASSO regression selected four DEO-MDRGs: NDUFV2, NDUFS7, OPA1, and NDUFA1. Their protein levels were reduced in AD mice with decreased mitochondrial function. These genes showed good diagnostic performance. Potential drugs, like ME-344 and metformin hydrochloride, may be useful in AD treatment.ConclusionsNDUFV2, NDUFS7, OPA1, and NDUFA1 can serve as biomarkers for AD diagnosis.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251339771"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of antidepressants on cognition in Alzheimer's disease with depression: A sub-group analysis of an open-label, observational study.","authors":"Eduardo Cumbo, Daniela Migliore","doi":"10.1177/13872877251340084","DOIUrl":"https://doi.org/10.1177/13872877251340084","url":null,"abstract":"<p><p>BackgroundDepressive symptoms are common in Alzheimer's disease (AD), leading to an increasing use of antidepressants.ObjectiveTo compare the effects of vortioxetine with other conventional antidepressants on cognition in AD patients with depressive symptoms.MethodsThis analysis is a subgroup of a 12-month, prospective, randomized, open-label, parallel-group study involving 108 outpatients receiving either vortioxetine or escitalopram, paroxetine, or bupropion as part of routine care. Data were collected at baseline, 6 and 12 months. Cognitive symptoms were assessed using the Mini-Mental State Examination (MMSE), Attentive Matrices (AM), Coloured Progressive Matrices (CPR), and Digit Span; depressive symptoms using the Hamilton Depression Scale (HAM-D) and the Cornell Scale for Depression in Dementia (CSDD). Results for patients on vortioxetine were compared to those on other antidepressants.ResultsTotal scores on cognitive measures improved in all groups. Improvements versus baseline in MMSE, AM, and CPM were statistically significant in the vortioxetine group (p < 0.001), but not in the other antidepressant groups. Digit Span scores did not differ significantly from baseline. The between-group differences in MMSE, AM, and CPM changes were statistically significant in favor of vortioxetine (p < 0.05), while the Digit Span change showed a trend towards superiority with vortioxetine, but did not reach statistical significance. The between-group differences in HAM-D and CSDD changes were also statistically significant for vortioxetine (p < 0.05).ConclusionsVortioxetine was superior in improving both cognitive and depressive symptoms compared to other antidepressants. Larger studies which may also help to understand whether the beneficial effect observed with vortioxetine was a direct effect or mediated by its specific antidepressant efficacy are required.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251340084"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red flags for remote cognitive diagnostic assessment: A Delphi expert consensus study by the Canadian Consortium on Neurodegeneration in Aging.","authors":"Nathan Hm Friedman, Sophie Hallot, Inbal Itzhak, Richard Camicioli, Alex Henri-Bhargava, Jacqueline A Pettersen, Linda Lee, John D Fisk, Paula McLaughlin, Vladimir Khanassov, Zahinoor Ismail, Morris Freedman, Howard Chertkow, Philippe Desmarais, Megan E O'Connell, Maiya R Geddes","doi":"10.1177/13872877251338186","DOIUrl":"https://doi.org/10.1177/13872877251338186","url":null,"abstract":"<p><p>Despite the potential benefits of remote cognitive assessment for dementia, it is not appropriate for all clinical encounters. Our aim was to develop guidance on determining a patient's suitability for comprehensive remote cognitive diagnostic assessment for dementia. A multidisciplinary expert workgroup was convened under the auspices of the Canadian Consortium on Neurodegeneration in Aging. We applied the Delphi method to determine 'red flags' for remote cognitive assessment of dementia. This resulted in 14 red flags that met the predetermined consensus criteria. We then developed a novel clinical decision-making infographic that integrated these findings to support multidisciplinary clinicians in determining a patient's readiness to undergo comprehensive remote cognitive assessment.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251338186"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in cognitive trajectories and practice effects in a cohort of older Londoners: The role of risk factors.","authors":"Sima Toopchiani, Shireen Sindi, Neil Poulter, Sujin Kang, Chi Udeh-Momoh, Geraint Price, Miia Kivipelto, Lefkos Middleton, Oliver Robinson","doi":"10.1177/13872877251339833","DOIUrl":"https://doi.org/10.1177/13872877251339833","url":null,"abstract":"<p><p>BackgroundSex differences in cognitive abilities have been reported; however, the underlying reasons remain unclear.ObjectiveTo (i) investigate sex differences in cognitive performance, (ii) evaluate the contributions of established dementia risk factors to these differences, and (iii) examine the role of non-modifiable risk factors on sex differences in cognitive performance.MethodsAmong 964 cognitively unimpaired participants (aged 60-85) of the UK CHARIOT-PRO Main Study, we assessed cross-sectional and longitudinal associations, over up to 3 years of follow-up, between sex and cognitive performance, using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).ResultsSex differences, mostly favoring women were observed at baseline across almost all RBANS indices including the total scale (Cohen's d = 0.3, adjusted mean difference in score = -5.4, p < 0.001). Sex differences were observed in Practice effects (PEs), with men showing less PE in almost all cognitive domains including the total scale (adjusted 1.3, p = 0.002). Greater sex differences in PEs, were documented among the 'older' participants in two out of five cognitive domains including the immediate memory index (mean difference: older (69-85 years) group = -3.2, p = 0.002); younger (60-68 years) group = -0.8, p = 0.4). Sex differences were more pronounced among 'Apolipoprotein-Ꜫ4 -carriers' in three out of five domains including the total scale (mean difference in carriers = -2.6, p = 0.002); non-carriers = -0.7, p = 0.3).ConclusionsSex differences in cognition and PE were observed after adjusting for risk factors associated with Alzheimer's disease. Future studies should also consider the effects of sex on non-modifiable risk factors and PEs to identify potential 'masked' neuropathology.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251339833"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-driven natural language processing for identifying linguistic patterns in Alzheimer's disease and mild cognitive impairment: A study of lexical, syntactic, and cohesive features of speech through picture description tasks.","authors":"Cynthia A Nyongesa, Mike Hogarth, Judy Pa","doi":"10.1177/13872877251339756","DOIUrl":"https://doi.org/10.1177/13872877251339756","url":null,"abstract":"<p><p>BackgroundLanguage deficits often occur early in the neurodegenerative process, yet traditional methods frequently fail to detect subtle changes. Natural language processing (NLP) offers a novel approach to identifying linguistic patterns associated with cognitive impairment.ObjectiveWe aimed to analyze linguistic features that differentiate cognitively unimpaired (CU), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups.MethodsData was extracted from picture description tasks performed by 336 participants in the DementiaBank datasets. 53 linguistic features aggregated into 4 categories: lexical, structural, syntactic, and discourse domains, were identified using NLP toolkits. With normal diagnostic cutoffs, cognitive function was evaluated with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).ResultsWith age and education as covariates, ANOVA and post-hoc Tukey's HSD tests revealed that linguistic features such as pronoun usage, syntactic complexity, and lexical sophistication showed significant differences between CU, MCI, and AD groups (p < 0.05). Notably, past tense and personal references were higher in AD than both CU and MCI (p < 0.001), while pronoun usage differed between AD and CU (p < 0.0001). Correlations indicated that higher pronoun rates and lower syntactic complexity were associated with lower MMSE scores and although some features like conjunctions and determiners approached significance, they lacked consistent differentiation.ConclusionsWith the growing adoption of artificial intelligence (AI)-based scribing, these results emphasize the potential of targeted linguistic analysis as a digital biomarker to enable continuous screening for cognitive impairment.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251339756"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the atherogenic index of plasma with cognitive function and oxidative stress: A population-based study.","authors":"Heng Zhang, Lin Shi, Na Tian, Min Zhu, Cuicui Liu, Tingting Hou, Yifeng Du","doi":"10.1177/13872877251334826","DOIUrl":"https://doi.org/10.1177/13872877251334826","url":null,"abstract":"<p><p>BackgroundAtherosclerosis contributes to cognitive dysfunction and Alzheimer's disease-related pathologies. Atherogenic index of plasma (AIP) is a novel and composite biomarker can predict atherosclerosis.ObjectiveThis study aims to (1) examine the association between the AIP and cognitive performance, and (2) explore the mediating role of oxidative stress biomarkers in this relationship.Methods1466 participants over the age of 60 were included from 2011-2014 NHANES. AIP was calculated through log-transformed triglyceride to high-density lipoprotein cholesterol ratios. The assessment of cognition was conducted using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test. Weighted linear regression model and restricted cubic spline were carried out to determine the associations between AIP and CERAD scores. The mediation analyses were conducted to assess whether oxidative stress mediates the association.ResultsHigher AIP levels were associated with lower CERAD learning scores. The highest quartile of AIP showed a 0.67-fold decrease (95%CI: -1.30, -0.03; p = 0.041) on the CERAD total score than that in the lowest quartile. Each 1-unit increase in AIP corresponded to reductions in CERAD total and delayed recall scores of approximately 1.09 and 0.54 points, respectively, in the sub-population under 70 years. Moreover, 25(OH)D, an oxidative stress indicator, partially mediated 24% of the association between AIP and the CERAD total score.ConclusionsAIP has the potential to indicate the risk of cognitive aging, especially that for young-old or female older adults. The supplementation of 25(OH)D may reduce atherosclerosis-related cognitive decline, which could provide some strategies for the prevention of dementia.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251334826"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic association of social participation with cognitive function: A bidirectional Mendelian randomization study.","authors":"Aoqiang Zhai, Ruiqi Zou, Tianrun Lv, Siqi Yang, Yanjie Zhong, Yang Xiong, Fuyu Li, Haijie Hu","doi":"10.1177/13872877251340078","DOIUrl":"https://doi.org/10.1177/13872877251340078","url":null,"abstract":"<p><p>BackgroundCognitive decline poses a significant challenge in aging societies. While some studies suggest that active social participation mitigates cognitive decline, others present conflicting findings.ObjectiveThis bidirectional two-sample Mendelian randomization (MR) study aimed to elucidate the causal relationship between social participation and cognitive function.MethodsThe cognitive performance dataset (n = 257,841) was used as the discovery sample, while cognitive function (n = 22,593) and Alzheimer's disease (AD) datasets (n = 394,705) served as replication samples and proxies for severe cognitive decline. Inverse variance weighting was the primary analytical method, supplemented by weighted median, MR-Egger, MR.RAPS, MR-PRESSO, and maximum likelihood methods for sensitivity analyses.ResultsSocial participation in sports club or gym (β = 0.09, 95% CI: 0.05 to 0.14, p < 0.001), religious group (β = 0.11, 95% CI: 0.08 to 0.14, p < 0.001) and other group activity (β = 0.06, 95% CI: 0.03 to 0.09, p < 0.001) reduced the risk of cognitive decline, while pub or social club (β = -0.06, 95% CI: -0.1 to -0.02, p = 0.005) and social inactivity (β = -0.05, 95% CI: -0.09 to -0.01, p = 0.017) accelerated cognitive decline. Improved cognitive performance promoted participation in beneficial activities and reduced pub or social club participation. Additionally, AD motivated visits to pub or social club (OR = 1.01, 95% CI: 1.00 to 1.03, p = 0.011).ConclusionsSpecific types of social participation may protect against cognitive decline, offering evidence for targeted interventions to prompt cognitive health in aging populations.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251340078"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Alzheimer's disease dementia: Examining inflammatory links to cognitive decline and neuropsychiatric symptoms.","authors":"Carolin Am Koriath, Robert Perneczky","doi":"10.1177/13872877251338467","DOIUrl":"https://doi.org/10.1177/13872877251338467","url":null,"abstract":"<p><p>Obesity is recognized as a risk factor for cardiovascular disease, vascular dementia, and Alzheimer's disease dementia (AD dementia). Emerging evidence indicates that obesity in AD patients is associated with heightened neuropsychiatric symptoms, as reflected by inflammatory biomarkers such as C-reactive protein and complement C3. Neuroinflammation, particularly through certain aspects of microglial activation, plays a significant role in AD development and cognitive decline. While further research is warranted to explore these neuroinflammatory pathways as potential therapeutic targets, proactive weight management starting in middle age may help mitigate both cognitive decline and neuropsychiatric symptoms.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251338467"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and research focus on autophagy in Alzheimer's disease (2003-2023): A bibliometric study.","authors":"Tianyi Wang, Haochen Jiang, Ruwen Zheng, Chuchu Zhang, Xiumei Ma, Yi Liu","doi":"10.1177/13872877251336442","DOIUrl":"https://doi.org/10.1177/13872877251336442","url":null,"abstract":"<p><p>BackgroundAlzheimer's disease (AD) is characterized by amyloid-β plaques and tau aggregates, with autophagy dysfunction playing a key pathogenic role. While autophagy modulation shows therapeutic promise, comprehensive bibliometric analyses are lacking.ObjectiveThis study aims to map the research landscape of autophagy in AD through bibliometric analysis, identifying key trends, contributors, and emerging focus areas.MethodsWe analyzed 4018 publications (2003-2023) from Web of Science using VOSviewer and CiteSpace. Publication trends, influential authors, countries, institutions, and research hotspots were examined through co-occurrence, burst detection, and clustering analyses.ResultsAnnual publications have steadily increased, peaking in 2022. The US led in output and citations, with major contributions from the University of California and New York University. Ralph A. Nixon emerged as the most influential author. Early research (2003-2013) primarily focused on protein degradation mechanisms, whereas recent studies (2014-2023) emphasize mitochondrial dysfunction, apoptosis, and related pathways. Key evolving topics include endoplasmic reticulum stress and chaperone-mediated autophagy, with significant implications for therapeutic innovation.ConclusionsAutophagy plays a critical role in AD pathogenesis and represents a promising therapeutic target. Despite mechanistic advances, clinical translation remains challenging. Future research should prioritize multi-omics integration, drug delivery optimization, and managing risks associated with excessive autophagy activation. These findings provide valuable insights for developing novel AD therapies targeting autophagy.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251336442"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated elevation of 181p-tau in the cerebrospinal fluid is associated with distinct clinical features: Findings from a Danish memory clinic cohort.","authors":"Laura Storm Næsborg Andersen, Anja Hviid Simonsen, Asmus Vogel, Oskar Hoffmann McWilliam, Steen Gregers Hasselbalch, Kristian Steen Frederiksen","doi":"10.1177/13872877251339679","DOIUrl":"https://doi.org/10.1177/13872877251339679","url":null,"abstract":"<p><p>BackgroundDeposition of amyloid-β and tau are key pathological events in Alzheimer's disease and may be assessed by cerebrospinal fluid (CSF) biomarkers. It remains uncertain whether patients who display abnormal phosphorylated tau in isolation differ from patients with other biomarker profiles.ObjectiveThe primary objective was to investigate differences in demographics, comorbidities, and cognitive performance in amyloid-β negative phosphorylated tau positive patients. Further, the aim was also to investigate the relationship between cognitive function and phosphorylated tau level.MethodsA total of 1049 consecutive patients from the Copenhagen Memory Clinic Cohort from 2018 to August 2022 were included and divided into four groups based on the CSF biomarkers amyloid-β₄₂ (A) and phosphorylated tau (T). Data on co-morbidities, abuse, and neuropsychological tests were recorded, and retrospective data analyses were performed across all groups.ResultsA total of 2.8% participants had an A-T+ biomarker profile and were younger (Mean: 65.1 years, SD: 14.2), comprised of more men (65.5%) than the A + T- group and exhibited both more psychiatric illness (p = 0.027) and alcohol and/or drug abuse (p = 0.004) than the A + T+ group. The A-T+ group performed better on both Addenbrooke's Cognitive Examination (p = 0.002) and Mini-Mental State Examination (p = 0.001) as well as immediate (p = 0.026) and delayed recall (p = 0.009) compared to the A + T+ group but showed no difference compared to the A-T- group on all cognitive scores. Further, higher p-tau levels were associated with worse cognitive performance although effects were small.ConclusionsThe findings indicate that patients with the A-T+ biomarker profile have different clinical characteristic that may indicate a non-neurodegenerative background.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251339679"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}