Journal of Alzheimer's Disease最新文献_第2页

Postmortem tau in the CA2 region of the hippocampus in older adult men who participated in youth amateur American-style football. 参加青少年业余美式足球的老年男子海马CA2区死后tau。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-26 DOI: 10.1177/13872877251351524

Grant L Iverson, Pouya Jamshidi, Amy Deep-Soboslay, Thomas M Hyde, Joel E Kleinman, Lili-Naz Hazrati, Rudolph J Castellani

{"title":"Postmortem tau in the CA2 region of the hippocampus in older adult men who participated in youth amateur American-style football.","authors":"Grant L Iverson, Pouya Jamshidi, Amy Deep-Soboslay, Thomas M Hyde, Joel E Kleinman, Lili-Naz Hazrati, Rudolph J Castellani","doi":"10.1177/13872877251351524","DOIUrl":"https://doi.org/10.1177/13872877251351524","url":null,"abstract":"BackgroundResearchers have reported that hyperphosphorylated tau (p-tau) accumulates in the Cornu Ammonis 2 subfield (CA2) of the hippocampus with age, preferentially in primary age-related tau astrogliopathy, in association with early Alzheimer's disease, and preferentially in chronic traumatic encephalopathy neuropathologic change.ObjectiveExamine the possible association between preferential p-tau in the CA2 region of the hippocampus and history of playing high school American-style football.MethodsPostmortem brain tissue samples were obtained from the Lieber Institute for Brain Development for 174 men (median age at death = 65 years; range = 50-96). There were 126 with no known history of participation in contact or collision sports and 48 (27.6%) who participated in football.ResultsApproximately half were rated modified Braak stage I (47.1%) and modified CERAD stage 0 (52.0%). Preferential CA2 p-tau was present in 29.9%. The average age for those with versus without preferential CA2 p-tau was 75 and 63, respectively (Cohen's d = -1.27, large effect).The sport history groups did not differ in age (p = 0.607). In both univariate and multivariate logistic regressions, older age groups (odds ratio [OR] = 3.42 and 3.23) and those with greater modified CERAD scores (OR = 1.78 and 1.48) were significantly more likely to have preferential CA2 p-tau. There was not a significant association between football participation and preferential CA2 p-tau.ConclusionsThere was not a significant association between participation in high school football and preferential CA2 p-tau identified after death. These results support other theories in the literature-that preferential CA2 p-tau is associated with aging and with Alzheimer's disease neuropathologic change.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251351524"},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial and socioeconomic influences on the interplay between Alzheimer's disease-related dementia and cardio-cerebrovascular disease in an aging population. 种族和社会经济对老年人群中阿尔茨海默病相关痴呆和心脑血管疾病相互作用的影响

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-26 DOI: 10.1177/13872877251351216

Chathura Siriwardhana, Enrique Carrazana, Kore Liow

{"title":"Racial and socioeconomic influences on the interplay between Alzheimer's disease-related dementia and cardio-cerebrovascular disease in an aging population.","authors":"Chathura Siriwardhana, Enrique Carrazana, Kore Liow","doi":"10.1177/13872877251351216","DOIUrl":"https://doi.org/10.1177/13872877251351216","url":null,"abstract":"BackgroundCardio and cerebrovascular disease (CVD) and Alzheimer's Disease-Related Dementia (ADRD) significantly impact older adult populations, with interlinked pathways influencing risk and progression. In Hawaii, where over 20% of the population is 65 or older and ethnic diversity is among the highest in the U.S., the relationship between ADRD and CVD requires closer examination, especially concerning racial and socioeconomic factors.ObjectiveThis study aims to assess the effects of race, ethnicity, and socioeconomic status on the bidirectional risk pathways between ADRD and CVD among older populations in Hawaii.MethodsUtilizing a multistate modeling framework, we analyzed nine years of longitudinal Medicare data to track transitions between ADRD, CVD, and mortality outcomes. We investigated associations among racial and ethnic groups, including Native Hawaiian and other Pacific Islander (NHPI), Asian Americans (AA) and white populations, accounting for socioeconomic status to identify disparities in risk progression and outcomes.ResultsThe analysis revealed notable racial and socioeconomic disparities in the transitions between ADRD, heart disease (HD), Stroke, and mortality among Hawaii's older population. Overall, lower socioeconomic status indicates increased risks for transitioning to more severe clinical states and mortality. However, such effects were found to be varied among races: AA, NHPI, and whites. Our findings suggest that socioeconomic status modifies the ADRD, HD, Stroke progression dynamics across different ethnicities.ConclusionsThis study highlights the significant role of race/ethnicity and socioeconomic status in the complex progression of ADRD and CVD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251351216"},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between education and rate of cognitive decline among individuals with Alzheimer's disease: A multi-national European observational study. 教育与阿尔茨海默病患者认知能力下降率之间的关系：一项欧洲多国观察性研究

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-26 DOI: 10.1177/13872877251352216

Zachary T Popp, Ting Fang Alvin Ang, Phillip H Hwang, Rhoda Au, Jinying Chen

{"title":"Association between education and rate of cognitive decline among individuals with Alzheimer's disease: A multi-national European observational study.","authors":"Zachary T Popp, Ting Fang Alvin Ang, Phillip H Hwang, Rhoda Au, Jinying Chen","doi":"10.1177/13872877251352216","DOIUrl":"https://doi.org/10.1177/13872877251352216","url":null,"abstract":"BackgroundThe cognitive reserve (CR) hypothesis presumes higher tolerance of Alzheimer's disease (AD)-related pathology without functional decline for those with high education and more rapid decline after AD onset. Evidence supporting the second part of the hypothesis has been largely confined to U.S.-based studies.ObjectiveTo assess the relationship between education and cognitive decline in a multi-national European cohort of older adults living with AD.MethodsWe analyzed data from participants recruited into the GERAS-EU cohort study from AD clinics in the United Kingdom, Germany, and France. Linear mixed models were employed to assess the relationship between education (dichotomized using a 12-year cutoff) and cognitive decline measured by Mini-Mental State Examination (MMSE) scores during 1.5 to 3 years of follow-up, adjusting for age, sex, time from formal diagnosis, country, comorbidities, and AD treatment.ResultsA total of 1313 participants were analyzed, with mean age of 77.3 years (SD = 7.6), 715 (54.5%) females, and 378 (28.8%) with high education (≥12 years). Participants with high education experienced a 0.19-point greater decline (versus low education group) in MMSE scores every 6 months during follow-up (95% Confidence Interval: 0.03-0.35, p = 0.02). The secondary analyses (stratified by disease severity, sex, or country) showed a consistent direction of the association, although only significant in the severe AD group (p = 0.01).ConclusionsOur findings provide partial support for the CR hypothesis. Delayed AD diagnosis in individuals with high education may contribute to faster decline after diagnosis, highlighting the importance of sensitive screening for early signs of cognitive impairment.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251352216"},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daily function outcomes in adults with mild cognitive impairment due to Alzheimer's disease after two years of processing speed training versus a control training protocol. 阿尔茨海默病引起的轻度认知障碍的成人在经过两年的处理速度训练与对照训练方案后的日常功能结果

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-26 DOI: 10.1177/13872877251351341

Virginia G Wadley, Yue Zhang, Tyler Bull, Cheyanne Barba, Yvonne Bolaji, R Nick Bryan, Michael Crowe, Lisa Desiderio, Guray Erus, David S Geldmacher, Rodney Go, Caroline L Lassen-Greene, Olga A Mamaeva, Daniel C Marson, Marianne McLaughlin, Ilya M Nasrallah, Cynthia Owsley, Jesse Passler, Rodney T Perry, Giovanna Pilonieta, Kayla A Steward, Andrea Wood, Richard E Kennedy

{"title":"Daily function outcomes in adults with mild cognitive impairment due to Alzheimer's disease after two years of processing speed training versus a control training protocol.","authors":"Virginia G Wadley, Yue Zhang, Tyler Bull, Cheyanne Barba, Yvonne Bolaji, R Nick Bryan, Michael Crowe, Lisa Desiderio, Guray Erus, David S Geldmacher, Rodney Go, Caroline L Lassen-Greene, Olga A Mamaeva, Daniel C Marson, Marianne McLaughlin, Ilya M Nasrallah, Cynthia Owsley, Jesse Passler, Rodney T Perry, Giovanna Pilonieta, Kayla A Steward, Andrea Wood, Richard E Kennedy","doi":"10.1177/13872877251351341","DOIUrl":"https://doi.org/10.1177/13872877251351341","url":null,"abstract":"BackgroundCognitive processing speed is integral to everyday activities and can be improved with training in persons with mild cognitive impairment (MCI). However, whether this training maintains everyday abilities is not known.ObjectiveWe aimed to determine whether everyday functions key to independence could be preserved with two years of processing speed training.MethodsIn a randomized controlled trial, we objectively evaluated a processing speed training protocol compared to a control training protocol, in 103 persons with MCI (n = 90) or very mild dementia (n = 13) due to Alzheimer's disease (AD). Each protocol involved serial assessments, laboratory training, and home training over a two-year period. We accounted for APOE ε4 carrier status and MRI-based neurodegeneration conducted at baseline. Outcomes were longitudinal changes in performance-based Instrumental Activities of Daily Living (IADLs), community mobility, and on-road driving. We used linear mixed models to evaluate changes in these outcomes over time.ResultsChanges in IADL function, driving, and community mobility did not differ by training assignment. Greater baseline neurodegeneration predicted larger declines in all functional outcomes (p values < 0.001).ConclusionsIn persons with MCI or very mild dementia, processing speed training was no more effective for maintaining everyday functions than training involving common computer activities and games that do not target processing speed. Greater baseline neurodegeneration predicted worse performance over time on all measures of function.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251351341"},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring frailty in dementia with Lewy bodies: A pilot, cross-sectional study. 探索衰弱与路易体痴呆：一个试点，横断面研究。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-26 DOI: 10.1177/13872877251352076

Fabrizia D'Antonio, Massimiliano Panigutti, Alice Teghil, Marco Toccaceli Blasi, Martina Salzillo, Giusi Talarico, Micaela Sepe Monti, Giuseppe Bruno, Marco Canevelli

引用次数: 0

Identifying patients with mild cognitive impairment at high risk of transitioning to Alzheimer's disease using routinely collected data. 使用常规收集的数据识别轻度认知障碍患者向阿尔茨海默病过渡的高风险。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-25 DOI: 10.1177/13872877251351622

Sreevani Katabathula, Mark Gurney, George Perry, Pamela B Davis, Rong Xu

{"title":"Identifying patients with mild cognitive impairment at high risk of transitioning to Alzheimer's disease using routinely collected data.","authors":"Sreevani Katabathula, Mark Gurney, George Perry, Pamela B Davis, Rong Xu","doi":"10.1177/13872877251351622","DOIUrl":"https://doi.org/10.1177/13872877251351622","url":null,"abstract":"BackgroundMild cognitive impairment (MCI) is a heterogeneous condition with variable progression to Alzheimer's disease (AD). Identifying MCI individuals at high risk for progression typically requires cerebrospinal fluid (CSF) biomarkers, magnetic resonance imaging (MRI), which are costly and invasive.ObjectiveThis study aimed to develop a cost-effective approach using routinely collected clinical data to identify a subgroup of MCI individuals at high risk for AD progression.MethodsAnalyses were conducted using the UK Biobank dataset, focusing on 1019 participants identified as having MCI, using the ICD-10 code F06.7 (mild neurocognitive disorder due to known physiological condition) in the absence of a dedicated diagnostic code for MCI. Participants (mean age = 71.7 years; 44% women) were characterized using routinely recorded demographic, comorbidity, and lifestyle data. A mixed-data clustering model was applied to classify individuals into subgroups. Clinical relevance of each cluster was evaluated using Kaplan-Meier survival analysis of MCI-to-AD progression over an average follow-up of 4.5 years.ResultsThree subtypes were identified with distinct progression risks: high-risk (HR), medium-risk (MR), and low-risk (LR). The HR subtype had significantly higher prevalence of hypertension (98%), cardiovascular disease (89%), diabetes (48%), and high cholesterol (67%) than MR and LR (p < 0.05). The HR group was younger on average but had greater comorbidity burden and higher likelihood of AD progression.ConclusionsThis study demonstrates the feasibility of using routinely collected data to identify high-risk MCI individuals. This approach offers a practical preliminary screening tool to prioritize individuals for targeted interventions and further specialized assessments.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251351622"},"PeriodicalIF":3.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Posterior cortical atrophy in the age of anti-amyloid treatments: An 11-year retrospective study of eligible patients from the Leenaards Memory Center. 抗淀粉样蛋白治疗年龄后皮质萎缩：一项对Leenaards记忆中心合格患者的11年回顾性研究。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-25 DOI: 10.1177/13872877251342266

Paolo Salvioni Chiabotti, Mirco Nasuti, Olivier Rouaud, Gilles Allali

引用次数: 0

Association between pineal volume reduction and affective dysregulation in amnestic mild cognitive impairment: The role of mild behavioral impairment. 健忘轻度认知障碍患者松果体体积减少与情感失调的关系：轻度行为障碍的作用。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-24 DOI: 10.1177/13872877251352081

Teruyuki Matsuoka, Ayu Imai, Chikara Nakayama, Jin Narumoto

{"title":"Association between pineal volume reduction and affective dysregulation in amnestic mild cognitive impairment: The role of mild behavioral impairment.","authors":"Teruyuki Matsuoka, Ayu Imai, Chikara Nakayama, Jin Narumoto","doi":"10.1177/13872877251352081","DOIUrl":"https://doi.org/10.1177/13872877251352081","url":null,"abstract":"BackgroundMild behavioral impairment (MBI) and pineal volume reduction are early indicators of Alzheimer's disease (AD). Thus, the pineal volume reduction observed in early AD may be associated with MBI. Given that pineal volume reduction may be specific to AD, it might also be related to amnestic mild cognitive impairment (aMCI).ObjectiveIn this study, we aimed to examine the relationship between MBI and pineal volume reduction in mild cognitive impairment (MCI; including aMCI and non-amnestic MCI) and normal cognition.MethodsThis retrospective study included 86 patients aged ≥ 50 years with either MCI or normal cognition. Stepwise Linear regression analyses were conducted to examine the association between MBI and pineal parenchymal volume (PPV). PPV was manually measured using brain magnetic resonance imaging data. The dependent variable was the MBI Checklist (MBI-C) score. In contrast, independent variables included PPV, total intracranial volume, age, sex, Mini-Mental State Examination score, psychotropic drug use, and antidementia drug use.ResultsPPV was the sole significant predictor of the MBI-C impulse dyscontrol score in the overall sample (adjusted R²: 0.058, p: 0.014, β: 0.263) and the sole significant predictor of the MBI-C affective dysregulation score in individuals with aMCI (adjusted R²: 0.117, p: 0.014, β: -0.371).ConclusionsPineal volume reduction was associated specifically with MBI affective dysregulation symptoms in individuals with aMCI. As affective dysregulation is an early symptom of AD, these findings suggest a potential link between this symptom and pineal volume reduction, a feature potentially specific to AD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251352081"},"PeriodicalIF":3.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of semaglutide with Alzheimer's disease-related dementias in patients with type 2 diabetes: A real-world target trial emulation study. 西马鲁肽与2型糖尿病患者阿尔茨海默病相关痴呆的关联：一项真实世界的目标试验模拟研究

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-24 DOI: 10.1177/13872877251351329

William Wang, Pamela B Davis, Xin Qi, Mark Gurney, George Perry, Nora D Volkow, David C Kaelber, Rong Xu

{"title":"Associations of semaglutide with Alzheimer's disease-related dementias in patients with type 2 diabetes: A real-world target trial emulation study.","authors":"William Wang, Pamela B Davis, Xin Qi, Mark Gurney, George Perry, Nora D Volkow, David C Kaelber, Rong Xu","doi":"10.1177/13872877251351329","DOIUrl":"https://doi.org/10.1177/13872877251351329","url":null,"abstract":"BackgroundAlmost half of the dementia cases are preventable. Semaglutide treats several medical conditions that are risk factors for dementia.ObjectiveWe aim to investigate if semaglutide is associated with a decreased risk of dementia.MethodsWe conducted emulation target trials based on a nationwide population-based database of patient electronic health records (EHRs) in the US among 1,710,995 eligible patients with type 2 diabetes (T2D) comparing semaglutide with other antidiabetic medications. First-time diagnosis of Alzheimer's disease-related dementia (ADRD) including vascular dementia, frontotemporal dementia, Lewy body dementia and other dementias were examined using Cox proportional hazards and Kaplan-Meier survival analyses during a 3-year follow-up. Models were adjusted by propensity-score matching.ResultsWe show that semaglutide was associated with a significantly reduced risk of overall ADRD incidence with a hazard ratio ranging from 0.54 (0.49-0.59) compared with insulin, 0.67 (0.61-0.74) compared with metformin, to 0.80 (0.72-0.89) compared with older generation glucagon-like peptide-1 agonists (GLP-1RAs). The association varied for specific dementia types, with significantly reduced risk of vascular dementia and no evidence of associations with frontotemporal and Lewy body dementias.ConclusionsThese findings provide evidence supporting protective effects of semaglutide on dementias in patients with T2D. Future works are needed to establish the causal relationships through randomized clinical trials and to characterize the underlying mechanisms.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251351329"},"PeriodicalIF":3.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescription-based association of P-glycoprotein substrates with Alzheimer's disease risk: A nested case-control study. 基于处方的p糖蛋白底物与阿尔茨海默病风险的关联：一项巢式病例对照研究

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-06-23 DOI: 10.1177/13872877251351629

Joseph Asante, Corey L Nagel, Steven W Barger

{"title":"Prescription-based association of P-glycoprotein substrates with Alzheimer's disease risk: A nested case-control study.","authors":"Joseph Asante, Corey L Nagel, Steven W Barger","doi":"10.1177/13872877251351629","DOIUrl":"https://doi.org/10.1177/13872877251351629","url":null,"abstract":"BackgroundP-glycoprotein (P-gp) is linked to Alzheimer's disease (AD), as P-gp contributes to clearance of amyloid-β (Aβ) from the CNS. Thus, other P-gp substrates (Pgp-S) could affect Aβ clearance, either negatively through competitive inhibition or positively via cooperative transport, impacting risk for AD.ObjectiveWe probed impacts of Pgp-S on AD risk by querying AD rates among individuals prescribed medications that are considered Pgp-S.MethodsA retrospective cohort study was performed using the PharMetrics Plus database (IQVIA), encompassing 70,340 users of prescription drugs identified as Pgp-S and 352,382 Pgp-S non-users. Users and non-users were matched by age, sex, and geographical region. Cox regression models afforded adjustments for covariates and comorbidities.ResultsPgp-S use was generally associated with a significant reduction in the hazard ratio of AD in both crude (HR = 0.89, 95% CI = 0.79-0.99) and matched (HR = 0.87; 95% CI = 0.78-0.98) analyses. AD risk was higher among subsets diagnosed with comorbidities: depression (HR = 4.44; 95% CI, 3.99-4.94), stroke (HR = 1.98, 95% CI = 1.63-2.41), and hypertension (HR = 1.24, 95% CI = 1.13-1.36). In an analysis of individual drugs, digoxin (OR = 0.52, 95% CI, 0.34-0.77), atorvastatin (OR = 0.80, 95% CI, 0.73-0.87), omeprazole (OR = 0.83, 95% CI, 0.73-0.94), and prednisone (OR = 0.64, 95% CI, 0.46-0.86) were associated with significantly decreased odds of incident AD; rivaroxaban (OR = 1.29, 95% CI = 0.97-1.68) and mirabegron (OR = 1.45, 95% CI = 0.86-2.28) trended toward increased risk.ConclusionsThe findings suggest an association between Pgp-S use and AD, but limitations of the study design impel additional work to confirm the direction of impact for individual drugs.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251351629"},"PeriodicalIF":3.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0