Journal of Alzheimer's Disease最新文献_第2页

The long arm of divorce and death: Loss, loneliness, and cognition in mid and later life. 离婚与死亡的长臂：中老年生活中的失落、孤独与认知。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-05 DOI: 10.1177/13872877251394316

Jeffrey E Stokes, Erika A Pugh, Emily Briggs, Gina Lee, Amanda N Leggett, Mónika López-Anuarbe

{"title":"The long arm of divorce and death: Loss, loneliness, and cognition in mid and later life.","authors":"Jeffrey E Stokes, Erika A Pugh, Emily Briggs, Gina Lee, Amanda N Leggett, Mónika López-Anuarbe","doi":"10.1177/13872877251394316","DOIUrl":"https://doi.org/10.1177/13872877251394316","url":null,"abstract":"BackgroundEarly life adversities can have lifelong consequences for health, including for cognitive functioning and Alzheimer's disease and related dementias. Moreover, early-life disadvantages stemming from parental death and divorce have been linked with later life social, mental, and physical well-being outcomes, including social isolation. Therefore, loneliness stands out as an intervenable aspect of well-being that may mediate long-term consequences of early life exposure to parental death and divorce for midlife and older adults' cognitive decline.ObjectiveThe present study aims to determine whether early life exposures to parental death and/or divorce are associated with cognitive functioning in later life, and whether loneliness in midlife mediates such effects.MethodsWe used the 2014-2020 Health and Retirement Study (HRS), 2015 HRS Life History data and longitudinal structural equation modeling to address our research questions.ResultsEarly-life exposure to parental divorce, but not death, was associated with greater loneliness in late midlife and older age, and loneliness predicted more rapid declines to cognitive functioning over time. Mediation was statistically significant (p < 0.05).ConclusionsAlthough racial/ethnic minorities had higher exposure to both parental death and divorce, the effects of parental death and divorce were similar across race/ethnicity. Our results underscore the long-term impacts of parental divorce on well-being and health in adulthood and highlight loneliness as a critical determinant of cognitive declines and disparities in later life.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251394316"},"PeriodicalIF":3.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of childhood residential change with later life memory function and rate of decline in the US Health and Retirement Study. 美国健康与退休研究：童年居住改变与晚年记忆功能和衰退率的关系

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-05 DOI: 10.1177/13872877251394333

Dana M Alhasan, Abbey M Hamlin, Helen Cs Meier, Mark Manning, Xuexin Yu, Sirena Gutierrez, Noah J Webster

{"title":"Association of childhood residential change with later life memory function and rate of decline in the US Health and Retirement Study.","authors":"Dana M Alhasan, Abbey M Hamlin, Helen Cs Meier, Mark Manning, Xuexin Yu, Sirena Gutierrez, Noah J Webster","doi":"10.1177/13872877251394333","DOIUrl":"https://doi.org/10.1177/13872877251394333","url":null,"abstract":"BackgroundChildhood residential change may affect later-life memory function and risk for Alzheimer's disease. However, few studies have examined this relationship, particularly in minoritized racial/ethnic groups.ObjectiveTo assess the association between number of residences and moving due to financial difficulties in childhood with memory trajectories in later life.MethodsData were from the U.S. Health and Retirement Study. Childhood residential change was measured by the self-reported number of residences before age 16 (0-1, 2, 3, 4 or more; n = 4704). Moving due to financial difficulties before age 16 was categorized as yes versus no (n = 4651). Memory function was measured using composite memory z-scores incorporating direct and proxy assessments from 1996-2016. We utilized mixed-effects linear regression models with subject-specific random slopes and intercepts adjusting for sociodemographic characteristics to estimate associations between residential change and memory overall and by race/ethnicity and parental education.ResultsThe mean age at baseline was 57.6 ± 6.1 years, 78.7% self-identified as non-Hispanic (NH) White, 15.7% as NH-Black, and 5.6% as Other/Unknown. Descriptively, NH-Black adults reported fewer residential changes and had lower baseline memory performance compared to NH-White participants. More frequent residential change in childhood was associated with a slower rate of memory decline but not baseline memory function. Moving due to financial difficulties during childhood was not associated with initial memory levels or rates of memory decline. We did not observe effect modification by race/ethnicity or parental education.ConclusionsResults suggest that childhood residential change may contribute to later life memory trajectories.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251394333"},"PeriodicalIF":3.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of adverse childhood experiences and life course relationship quality with late-life cognitive health: Moderation by race/ethnicity and gender. 不良童年经历和生命历程关系质量与晚年认知健康的关联：种族/民族和性别的调节作用

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-05 DOI: 10.1177/13872877251394324

Monica E Walters, Roger Wong, Kiana A Scambray, Toni C Antonucci, Wassim Tarraf

{"title":"The association of adverse childhood experiences and life course relationship quality with late-life cognitive health: Moderation by race/ethnicity and gender.","authors":"Monica E Walters, Roger Wong, Kiana A Scambray, Toni C Antonucci, Wassim Tarraf","doi":"10.1177/13872877251394324","DOIUrl":"https://doi.org/10.1177/13872877251394324","url":null,"abstract":"BackgroundAdverse childhood experiences (ACEs) may increase Alzheimer's disease risk. How particular ACEs differentially relate to cognition and what role life course relationship quality (LCRQ) plays are unclear.ObjectiveAssess how ACEs subgroups relate to cognition and whether associations are impacted by LCRQ.MethodsAdults (ages 50-64 at baseline) from the Health and Retirement Study participated (n = 3225; 2006/2008 = baseline; 2018/2020 = follow-up). Latent class and profile analyses identified ACEs and LCRQ subgroups, respectively. Linear and multinomial logistic regressions related ACEs and LCRQ subgroups to global cognition, cognitive impairment, not dementia (CIND), and dementia at follow-up.ResultsWe identified 4 ACEs (High Adversity, Family Disruptions, Elevated Household Trauma, Low Adversity) and 3 LCRQ (\"Strong\", \"Mixed\", \"Weak\" Ties) classes. Racially/ethnically minoritized adults were more likely to belong to Family Disruptions and Weak Ties classes than White adults. Participants with Family Disruptions (versus Low Adversity) had worse cognition (global: b = -0.78, 95% CI [-1.19;-0.37]; CIND: RRR = 1.50, 95% CI [1.13;1.99]); controlling for LCRQ and sociodemographics attenuated associations. Participants with Weak Ties (versus Strong) had worse cognition (global: b = -2.90, 95% CI [-3.53;-2.26]; CIND: RRR = 3.16, 95% CI [2.12;4.70]; dementia: RRR = 3.64, 95% CI [1.92;6.90]); associations were not explained by covariates.ConclusionsFamily Disruptions negatively impacted cognition, but associations were attenuated by sociodemographics. Assessing life course resources as contributors to resilience may help explain the untenable ACEs-cognition association. However, negative LCRQ was consistently harmful to cognition. Targeting life course social relationships may benefit cognition.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251394324"},"PeriodicalIF":3.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroid plexus volume in Alzheimer's disease: A systematic review and meta-analysis. 阿尔茨海默病脉络膜丛容积：系统回顾和荟萃分析。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-04 DOI: 10.1177/13872877261447404

Farhad Mahmoudi, Mohammad Yazdan Panah, Danial Dehghani Firouzabadi, Saeed Vaheb, Hamed Ghoshouni, Ramon Flores Gonzalez, Vahid Shaygannejad, Omid Mirmosayyeb

{"title":"Choroid plexus volume in Alzheimer's disease: A systematic review and meta-analysis.","authors":"Farhad Mahmoudi, Mohammad Yazdan Panah, Danial Dehghani Firouzabadi, Saeed Vaheb, Hamed Ghoshouni, Ramon Flores Gonzalez, Vahid Shaygannejad, Omid Mirmosayyeb","doi":"10.1177/13872877261447404","DOIUrl":"https://doi.org/10.1177/13872877261447404","url":null,"abstract":"BackgroundAlzheimer's disease (AD) is marked by amyloid-β and tau accumulation, processes increasingly linked to impaired protein clearance and neuroinflammation. The choroid plexus (CP), which regulates cerebrospinal fluid (CSF) production and immune signaling, may contribute to these mechanisms. This review aimed to evaluate alterations in CP volume (CPV) in AD and their clinical significance.MethodsPubMed, Embase, Scopus, and Web of Science were searched up to March 2025. Eligible MRI-based studies comparing CPV between AD patients and healthy controls (HCs), as well as investigations examining associations of CPV with demographic, cognitive, structural, and pathological variables, were included. Random-effects models estimated pooled effect sizes, while narrative synthesis explored associations with clinical and pathological features.ResultsSixteen studies (2004 AD; 883 HCs) met inclusion criteria. Pooled findings demonstrated significantly larger CPV in AD relative to HCs (SMD = 1.05, 95% CI: 0.67 to 1.43; p < 0.01). Narrative review indicated consistent links between CP enlargement and worse cognition, hippocampal and cortical atrophy, ventricular expansion, and increased amyloid and tau deposition. CP changes were also associated with impaired glymphatic clearance and systemic inflammation. Notably, enlargement was observed in mild cognitive impairment, suggesting early involvement in the disease course.ConclusionsCP enlargement may represent a neuroimaging feature of AD, reflecting the interplay between impaired clearance mechanisms and neuroinflammatory processes. Given its visibility on routine MRI, CPV may hold considerable potential as an imaging marker for disease stratification and longitudinal monitoring of AD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877261447404"},"PeriodicalIF":3.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projected burden of Alzheimer's disease and other dementias in the Western Pacific, 2023-2050. 2023-2050年西太平洋地区阿尔茨海默病和其他痴呆症的预计负担。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-04 DOI: 10.1177/13872877261441774

Roy Rillera Marzo, Man Li, Qizhi Yang, Hana Chen, Rany Sam, Maryam Farooqui, Manah Chandra Changmai, Zhumabekova Bibigul, Aubakirova Karlygash, Titik Respati, Dandan Xu, Hongpeng Zhang, Wegayehu Sheferaw, Zelalem Meraf Wolde

{"title":"Projected burden of Alzheimer's disease and other dementias in the Western Pacific, 2023-2050.","authors":"Roy Rillera Marzo, Man Li, Qizhi Yang, Hana Chen, Rany Sam, Maryam Farooqui, Manah Chandra Changmai, Zhumabekova Bibigul, Aubakirova Karlygash, Titik Respati, Dandan Xu, Hongpeng Zhang, Wegayehu Sheferaw, Zelalem Meraf Wolde","doi":"10.1177/13872877261441774","DOIUrl":"https://doi.org/10.1177/13872877261441774","url":null,"abstract":"BackgroundAlzheimer's disease and other dementias (ADODs) are increasing rapidly with population aging, yet region-specific projections for the Western Pacific remain limited.ObjectiveTo project ADOD disability-adjusted life-years (DALYs) and deaths in the Western Pacific to 2050 and evaluate how modifying key risk factors could inform policy and planning.MethodsUsing the Global Burden of Disease 2021 scenario framework, we modeled ADOD burden for 37 Western Pacific countries/areas (2023-2050), stratified by age and sex. Primary outcomes were all-age DALY and death rates per 100,000. Projections included a reference and four counterfactual scenarios. Uncertainty was estimated using 1000 Monte Carlo draws, summarized with 95% uncertainty intervals (UIs).ResultsRegional DALY rates rise from 777.6 (95% UI 375.5-1714.8) in 2023 to 1980.9 (964.7-4176.9) in 2050 (+154.7%), while death rates increase from 41.1 (10.5-110.2) to 119.7 (30.5-302.8) (+191.3%). Female rates exceed male rates throughout, widening absolute sex gaps. By 2050, ages 80-94 account for ∼62% of DALYs and ∼69% of deaths; ≥95 contribute ∼10% and ∼17%. Japan remains highest, while the Republic of Korea approaches comparable levels. China and Singapore show the steepest absolute increases. Scenario curves remain similar until the 2040s; small differences by 2050 reflect survival-driven cohort expansion at high-risk ages.ConclusionsDemographic aging will dominate Western Pacific dementia burden through mid-century. Prevention remains critical to delay onset, compress disability, and improve overall healthy aging, but demographic aging will still drive substantial growth in service needs. Health systems must scale dementia-capable primary care, long-term and palliative services, caregiver support, and gender-responsive planning.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877261441774"},"PeriodicalIF":3.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketogenic diet enhances cognitive-behavioral function and hippocampal neurogenesis while attenuating amyloid pathology in Tg-SwDI mice. 生酮饮食增强Tg-SwDI小鼠的认知行为功能和海马神经发生，同时减弱淀粉样蛋白病理。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-04 DOI: 10.1177/13872877261445916

Victoria E Pulido-Correa, Ariana V Hernandez, Eleanor J Wind, YingYing Zhu, Chana Vogel, Shaina Binu, Mikayla Jeneske, Dylan Kuni, Vedika Chiduruppa, Bianca Echeverria, Lauren Rosenberg, Lisa S Robison

{"title":"Ketogenic diet enhances cognitive-behavioral function and hippocampal neurogenesis while attenuating amyloid pathology in Tg-SwDI mice.","authors":"Victoria E Pulido-Correa, Ariana V Hernandez, Eleanor J Wind, YingYing Zhu, Chana Vogel, Shaina Binu, Mikayla Jeneske, Dylan Kuni, Vedika Chiduruppa, Bianca Echeverria, Lauren Rosenberg, Lisa S Robison","doi":"10.1177/13872877261445916","DOIUrl":"https://doi.org/10.1177/13872877261445916","url":null,"abstract":"BackgroundThe ketogenic diet (KD), characterized by high-fat, low-carbohydrate, and moderate protein intake, has gained attention for its therapeutic potential in patients with neurodegenerative diseases, including Alzheimer's disease (AD). Studies in AD rodent models report that KD and/or ketogenic supplements attenuate cognitive-behavioral impairments, neuroinflammation, amyloid-β (Aβ) plaques, and tau pathology. However, it is unknown whether KD can similarly benefit individuals with cerebral amyloid angiopathy (CAA), a prevalent condition in which Aβ accumulates in cerebral vessels. CAA is highly comorbid with AD and, on its own, increases the risk of stroke, cognitive impairment, and dementia, yet no effective treatments currently exist.ObjectiveTo determine whether KD can improve cognitive-behavioral and neuropathological outcomes in a mouse model with CAA.MethodsMale Tg-SwDI mice were fed either a standard chow or KD from 3.5 to 7.5 months of age. Following ∼3 months of dietary intervention, glucose and ketone body levels were assessed, then mice underwent a battery of behavioral tests to evaluate locomotor activity, anxiety-related behaviors, and cognition. Immunohistochemistry was performed to assess amyloid pathology, vascular density, neuroinflammation, white matter integrity, and hippocampal neurogenesis.ResultsIn addition to KD inducing nutritional ketosis and achieving metabolic benefits, mice on KD exhibited increased activity, enhanced spatial learning and memory, and a trend toward improved spatial working memory. These cognitive benefits were accompanied by an attenuation of amyloid pathology and increased hippocampal neurogenesis.ConclusionsThese findings suggest that a KD may be safe and effective in AD and dementia patients with CAA.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877261445916"},"PeriodicalIF":3.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causes of death in patients with dementia: A study in a geriatric hospital in São Paulo, Brazil. 痴呆症患者的死亡原因：巴西圣保罗一家老年医院的研究。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-04 DOI: 10.1177/13872877261445578

Yngrid Dieguez Ferreira, Carolina Braga Moura, Amanda Carneiro Rodrigues, Anderson Matheus Pereira Da Silva, Diogo Haddad Santos, Maria Fernanda Mendes

{"title":"Causes of death in patients with dementia: A study in a geriatric hospital in São Paulo, Brazil.","authors":"Yngrid Dieguez Ferreira, Carolina Braga Moura, Amanda Carneiro Rodrigues, Anderson Matheus Pereira Da Silva, Diogo Haddad Santos, Maria Fernanda Mendes","doi":"10.1177/13872877261445578","DOIUrl":"https://doi.org/10.1177/13872877261445578","url":null,"abstract":"BackgroundDementia contributes to morbidity and mortality in aging populations, with infectious diseases as frequent terminal events. In Brazil, data on causes of death in dementia and hospital-based end-of-life care are limited.ObjectiveTo describe causes of death, clinical characteristics, and pharmacological treatment patterns during the last month of life among patients with dementia hospitalized in a geriatric hospital in São Paulo, Brazil.MethodsThis retrospective observational study included all patients with clinically diagnosed dementia who died between 2015 and 2023 in a specialized geriatric hospital. Demographic, clinical, and pharmacological data were extracted from electronic medical records. Causes of death were classified using ICD-10 codes. Associations between dementia subtypes and infection-related deaths were evaluated using logistic regression adjusted for age, sex, and comorbidities. Statistical analyses were performed using R, with p < 0.05 considered significant.ResultsA total of 122 patients were included (mean age 83.6 ± 7.4 years; 61.5% female). Alzheimer's disease was the most frequent subtype (52.5%), followed by vascular (26.2%) and mixed dementia (21.3%). Infectious diseases accounted for 67.2% of deaths, mainly pneumonia (48.3%) and sepsis (18.9%). Antibiotics were prescribed in 76.2% of cases, and antipsychotics in 58.1%. Palliative care measures were documented in 41.0% of cases.ConclusionsInfectious diseases were the most frequent causes of death among hospitalized patients with dementia, with high antibiotic use and limited palliative care documentation. These findings indicate the need for integrated end-of-life protocols and improved recognition of palliative needs.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877261445578"},"PeriodicalIF":3.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting after learning facilitates memory consolidation and reverses spatial reorientation impairments in female 3xTg-AD mice. 学习后休息有助于记忆巩固并逆转3xTg-AD雌性小鼠的空间定向障碍。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-04 DOI: 10.1177/13872877261429996

Alina C Stimmell, Leslie J Alday, Emily M Salvador, Johanna Marquez Diaz, Shawn C Moseley, Sarah D Cushing, Yicheng Zheng, Jordan D Ogg, Sydney M Ragsdale, Aaron A Wilber

{"title":"Resting after learning facilitates memory consolidation and reverses spatial reorientation impairments in female 3xTg-AD mice.","authors":"Alina C Stimmell, Leslie J Alday, Emily M Salvador, Johanna Marquez Diaz, Shawn C Moseley, Sarah D Cushing, Yicheng Zheng, Jordan D Ogg, Sydney M Ragsdale, Aaron A Wilber","doi":"10.1177/13872877261429996","DOIUrl":"https://doi.org/10.1177/13872877261429996","url":null,"abstract":"BackgroundSleep is an essential component of memory consolidation and waste clearance, including pathology associated with Alzheimer's disease (AD). Facilitation of sleep decreases amyloid-β (Aβ) and tau accumulation and is important for memory consolidation.ObjectiveWe previously found that 6-month female 3xTg-AD mice were impaired at spatial reorientation learning and memory. Given the association between sleep and AD, we assessed the impact of added rest on impaired spatial reorientation that we previously observed.MethodsWe randomly assigned 3xTg-AD mice to a sleep (n = 7; 50-60 min pre- & post-task induced rest) or a non-sleep group (n = 7; remained in home cage pre- & post- task). Mice in both groups were compared to non-Tg, age-matched, non-sleep controls (n = 6). To confirm that our rest condition induced sleep, we performed the same experiment with rest sessions for both 3xTg-AD and non-Tg mice (n = 5/group) implanted with recording electrodes to capture local field potentials, which were used to classify sleep states. Markers of pathology (AT8, 6E10, M78, and M22) were also assessed in the parietal-hippocampal network, where we previously showed pTau (AT8) positive cell density predicted spatial reorientation ability.ResultsWe found that 3xTg-AD sleep mice were unimpaired at spatial reorientation compared to non-Tg mice and performed better than 3xTg-AD non-sleep mice (replicating our previous work). This recovered behavior was apparent despite no change in the density of pathology-positive cells. Further, theta-gamma coupling during sleep may explain the facilitated cognition in 3xTg-AD sleep mice, suggesting brain activity patterns during sleep may mediate the restored cognition.ConclusionsImproving sleep in early stages of AD pathology offers a promising approach for facilitating memory consolidation and improving cognition.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877261429996"},"PeriodicalIF":3.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of longitudinal change in proper name recall with pTau217 as a marker of early cognitive decline in cognitively unimpaired adults at risk for Alzheimer's disease dementia. pTau217在阿尔茨海默病痴呆风险的认知功能正常的成年人中作为早期认知能力下降标志的正名记忆纵向变化的验证

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-04 DOI: 10.1177/13872877261446477

Kristin Basche, Deling He, Rebecca Langhough, Erin Jonaitis, Lianlian Du, Davide Bruno, Rachael Wilson, Bruce Hermann, Sterling Johnson, Kimberly Mueller

{"title":"Validation of longitudinal change in proper name recall with pTau217 as a marker of early cognitive decline in cognitively unimpaired adults at risk for Alzheimer's disease dementia.","authors":"Kristin Basche, Deling He, Rebecca Langhough, Erin Jonaitis, Lianlian Du, Davide Bruno, Rachael Wilson, Bruce Hermann, Sterling Johnson, Kimberly Mueller","doi":"10.1177/13872877261446477","DOIUrl":"https://doi.org/10.1177/13872877261446477","url":null,"abstract":"BackgroundPrevious work has shown that proper name recall from the Logical Memory (LM) task is sensitive to PET and cerebrospinal fluid biomarkers of Alzheimer's disease (AD) in older adult populations. These findings indicate potential utility in identifying preclinical AD.ObjectiveThe purpose of this study is to validate previous findings of the association of proper name recall and blood-based plasma pTau217.MethodsParticipants came from the Wisconsin Registry for Alzheimer's Prevention study. We fit linear mixed effects models of longitudinal LM and proper name recall as a function of most recent pTau217 values. Follow-up analyses added interaction terms to models for group differences in sex and APOE ε4 allele carriage. As an exploratory aim, logistic regression models were used to examine if proper name recall aided in predicting clinical diagnosis.ResultsParticipants with higher concentrations of pTau217 showed a steeper decline on both conventional LM and proper name recall. APOE ε4 allele carriers with higher concentrations of pTau217 showed a greater decline in longitudinal task performance, while there was no significant interaction for sex, indicating that men and women with high pTau217 show similar rates of decline.ConclusionsOur findings validate that proper name recall is sensitive to blood-based pTau217. Measuring proper name recall may be an efficient marker assessing early cognitive change that could be leveraged when designing future cognitive tests.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877261446477"},"PeriodicalIF":3.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on the current state of speech and language testing in Alzheimer's disease. 阿尔茨海默病言语和语言测试现状的最新进展。

IF 3.1 3区医学

Journal of Alzheimer's Disease Pub Date : 2026-05-04 DOI: 10.1177/13872877261446637

Shloka Dhareshwar, Melissa Kane, Courtney Lewis, Ruby Mineur, Kylie Yao, Peter J Snyder, Jessica Alber, Catherine Robb, Yen Ying Lim, Adam P Vogel

引用次数: 0