Stephanie R Rainey-Smith, Kelsey R Sewell, Belinda M Brown, Hamid R Sohrabi, Ralph N Martins, Samantha L Gardener
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引用次数: 0
摘要
在全球范围内,咖啡和茶被广泛消费,可能通过抗炎和抗氧化应激作用提供神经保护。目的探讨咖啡和茶摄入量与认知功能的关系。方法在一项纵向前瞻性队列研究中,无痴呆患者(n = 8715;来自英国生物银行(UK Biobank)的年龄在60.0-85.2岁之间的老年人自我报告了过去一年的咖啡和茶摄入量;“从不”、“适度”(1-3杯/天)或“高”(≥4杯/天)。参与者在≥2个时间点(平均9.11年)完成认知评估。结果“从不”喝咖啡和“适度”喝咖啡的人(β = 0.06, p = 0.005;β = 0.07, p = 0.06, p = 0.009;β = 0.06, p = 0.003)患儿的流体智力下降较慢。此外,那些“从不”喝咖啡和“适度”喝咖啡的人配对错误的增加速度较慢(β = -0.05, p = 0.022;β = 0.05, p = 0.013),与“高”消费者相比。结论:“适量”咖啡、“适量”和“高”茶摄入量可能是防止认知能力下降的保护因素。需要随机对照试验来建立因果关系,从而得出关于咖啡和茶摄入益处的循证建议。
Moderate coffee and tea consumption is associated with slower cognitive decline.
BackgroundGlobally, coffee and tea are consumed extensively, potentially providing neuroprotection through anti-inflammatory and antioxidative stress effects.ObjectiveThis study aimed to investigate associations between coffee and tea intake and cognitive function.MethodsIn a longitudinal prospective cohort study, dementia-free (n = 8715; age range 60.0-85.2 years) older adults from the UK Biobank self-reported coffee and tea intake over the previous year; 'never', 'moderate' (1-3 cups/day), or 'high' (≥4 cups/day). Participants completed cognitive assessments at ≥2 timepoints (mean of 9.11 years).ResultsThose 'never' consuming coffee and 'moderate' coffee consumers (β = 0.06, p = 0.005; β = 0.07, p < 0.001, respectively), as well as 'moderate' tea consumers and 'high' tea consumers (β = 0.06, p = 0.009; β = 0.06, p = 0.003, respectively) had slower fluid intelligence decline. Additionally, those 'never' consuming coffee and 'moderate' coffee consumers had a slower increase in pairs matching errors (β = -0.05, p = 0.022; β = 0.05, p = 0.013) compared to 'high' consumers.Conclusions'Moderate' coffee, and 'moderate' and 'high' tea intake may be a protective factor against cognitive decline. Randomized controlled trials are required to establish causal relationships leading to evidence-based recommendations regarding benefits of coffee and tea intake.
期刊介绍:
The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.