Journal of Alzheimer's Disease最新文献

{"title":"Institutionalization of persons with Alzheimer's disease in the Czech and Slovak Republics.","authors":"Kristina Randlová, Peter Pažitný, Daniela Kandilaki","doi":"10.1177/13872877251317987","DOIUrl":"https://doi.org/10.1177/13872877251317987","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of Alzheimer's disease (AD) is increasing, and with it comes the demand for specialized services. Current information on the institutionalization of patients with AD is limited.</p><p><strong>Objective: </strong>To determine the level of institutionalization among AD patients in the facilities of the Czech Republic and the Slovak Republic.</p><p><strong>Methods: </strong>A survey of the rate of institutionalization in facilities in the Czech Republic and Slovak Republic. The survey collects data on the institutionalization of patients suffering from AD in relation to the capacity of the facilities and the prevalence of the disease. Data were collected by representative quantitative survey, during years 2019-2021.</p><p><strong>Results: </strong>Patients with AD occupy approximately 25% of the total capacities of institutions in the Czech and Slovak Republics. The rate of institutionalization of patients with AD is estimated at 20.5% in the Czech Republic and 24% in the Slovak Republic. This is more than the estimated worldwide rate of institutionalization of people with AD (16%) but less than the estimated rate of institutionalization of these patients in high-income countries (31%).</p><p><strong>Conclusions: </strong>As the prevalence of AD increases, so do the demands for care. If there is no increase in institutional capacity, this growth will put more pressure on home care. In order to provide specialized care to as many patients as possible, emphasis must be placed on increasing the capacity of institutions.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251317987"},"PeriodicalIF":3.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between attentional control, episodic memory, and Alzheimer's disease biomarkers of tau and neurodegeneration.","authors":"Marta Stojanovic, Peter R Millar, Nicole S McKay, Andrew J Aschenbrenner, David A Balota, Jason Hassenstab, Tammie Ls Benzinger, John C Morris, Beau M Ances","doi":"10.1177/13872877251316801","DOIUrl":"https://doi.org/10.1177/13872877251316801","url":null,"abstract":"<p><strong>Background: </strong>While episodic memory decline is the most common cognitive symptom of Alzheimer's disease (AD), changes in attentional control have also been found to be sensitive to early AD pathology. The relations between longitudinal trajectories of these specific cognitive domains, especially attentional control, and biomarkers of tau and neurodegeneration have not been thoroughly examined.</p><p><strong>Objective: </strong>We examined whether baseline tau positron emission tomography (PET) and cortical thickness, relatively later markers within the AD cascade, predicted cross-sectional and longitudinal changes in episodic memory and attentional control.</p><p><strong>Methods: </strong>Cognitively normal individuals ([Clinical Dementia Rating CDR^®] = 0; n = 249) at baseline completed a magnetic resonance imaging (MRI), tau PET, and multiple assessments of episodic memory and attentional control. Generalized additive mixed-effects models examined whether tau PET summary measure and cortical thickness signature predicted cross-sectional and longitudinal trajectories of attentional control and episodic memory.</p><p><strong>Results: </strong>Higher tau PET and lower MRI cortical thickness were generally associated with worse cross-sectional cognitive performance. Our exploratory analyses found cortex-wide associations between tau PET and episodic memory, with limited suggestions of region-specific associations with attentional control. On longitudinal follow-up, higher tau PET was associated with a greater decline in episodic memory.</p><p><strong>Conclusions: </strong>These results indicate that tau PET is particularly sensitive to detecting longitudinal changes in episodic memory. This further informs relevant endpoints for clinical drug trials in cognitively normal individuals. Future studies might consider longer follow-ups and lag associations between changes in AD biomarkers and changes in cognition.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251316801"},"PeriodicalIF":3.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer's disease in the Kingdom of Saudi Arabia: Current perspectives and genetic insights.","authors":"Amnah A Alharbi, Hanan E Alatwi, Hana Albulaihe, Norah K Algarzae","doi":"10.1177/13872877251316122","DOIUrl":"https://doi.org/10.1177/13872877251316122","url":null,"abstract":"<p><p>The prevalence of dementia and mild cognitive disorder has markedly risen in recent years. Alzheimer's disease (AD) stands out as the most common form of neurodegenerative dementia among the elderly, featuring progressive memory loss and cognitive decline. Although the exact biological causes of AD are complex and multifactorial, genetics is considered a prominent contributor. To date, around 80 genetic loci have been identified, primarily in European ancestry groups, though a considerable portion of AD's genetic architecture remains elusive. Recognizing the impending rise in AD cases, both governmental and private sectors in Saudi Arabia are making efforts to enhance formal care and services for older adults. While few studies have investigated AD-susceptible genes within the Saudi population, further attention is needed to explore the genetic background and identify molecular biomarkers associated with AD. This review provides an overview of the current understanding of AD and recent genetic research in Saudi Arabia.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251316122"},"PeriodicalIF":3.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of glial ApoE secretion by the mevalonate pathway is independent of ApoE isoform.","authors":"Joshua L Milstein, Joshua A Kulas, Aria Kamal, An B Lo, Heather A Ferris","doi":"10.1177/13872877251317732","DOIUrl":"https://doi.org/10.1177/13872877251317732","url":null,"abstract":"<p><strong>Background: </strong>Lipids synthesized in astrocytes are distributed to other brain cells in high-density lipoprotein-like ApoE particles. ApoE, which is a powerful genetic risk factor for developing Alzheimer's disease, is secreted differently depending on genotype. Secretion of ApoE from mouse astrocytes is regulated by the mevalonate pathway.</p><p><strong>Objective: </strong>We aimed to understand if the regulation of ApoE secretion from astrocytes by the mevalonate pathway was the same between mouse ApoE and ApoE from humanized mice, and if this is impacted by ApoE isoform.</p><p><strong>Methods: </strong>Astrocyte-enriched glial cultures from wild-type and humanized ApoE targeted-replacement mice were treated with pharmacological inhibitors of various steps along the mevalonate pathway and ApoE in the conditioned media was measured.</p><p><strong>Results: </strong>We show that statins and prenylation inhibitors, but not specific cholesterol inhibitors, reduce extracellular ApoE lipoparticle levels in astrocyte-enriched glial cultures, and that this occurs in cells harboring either the mouse ApoE or any of the three human ApoE genotypes to a similar extent. We find that geranylgeranylation modulates ApoE release from astrocytes, and it does so independent of ApoE genotype.</p><p><strong>Conclusions: </strong>Our results suggest that prenylation broadly regulates ApoE secretion from astrocytes regardless of ApoE genotype, and that this is mediated specifically by geranylgeranylation. Therefore, our data implicates geranylgeranylation as a general mechanism modulating ApoE release from astrocytes, but likely is not responsible for the reported baseline differences in ApoE secretion seen in vivo and in vitro across genotypes.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251317732"},"PeriodicalIF":3.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dance-like state detection, curiosity, and decentering: A pilot study on artful movement and mindfulness.","authors":"Aston K McCullough, Siobhan Lawless, Bruna Martins-Klein","doi":"10.1177/13872877251315054","DOIUrl":"https://doi.org/10.1177/13872877251315054","url":null,"abstract":"<p><strong>Background: </strong>Curiosity and decentering are two constructs that represent momentary mindfulness. Dance is an art and complex physical activity mode, which may serve as a behavioral correlate of mindfulness.</p><p><strong>Objective: </strong>To characterize momentary mindfulness in relation to a novel, accelerometer-derived measure for characterizing human movement quality (i.e. \"dance-like state\" DLS scores).</p><p><strong>Methods: </strong>Adults (<i>N </i>= 41), ages 18-83 years old, engaged in the following conditions in a lab and completed questionnaires on mindfulness after each: (1) clipping their fingernails; (2) sitting, standing, and walking on a treadmill; and (3) dancing at self-determined reference intensities with and without music. Conditions 2-3 were monitored with accelerometers. DLS score summary statistics (i.e. median and median amplitude deviation [MAD]) were used in linear mixed effects models.</p><p><strong>Results: </strong>On average, curiosity [<i>13.7</i>(1.02)] was significantly associated with median DLS scores (<i>β </i>= 1.79, <i>p </i>= 0.007) over time; adults with a lower median DLS score reported higher levels of curiosity [16.2; 95%C.I. 13.3-19.0], on average, when compared [12.6; 95%C.I., 10.3-14.9] to adults with a higher median DLS score. On average, decentering [<i>14.9</i>(1.01)] was significantly associated with the DLS score MAD (<i>β </i>= 1.28, <i>p </i>= 0.035) over time; adults who had less variability in DLS scores across conditions reported greater experiences of decentering [15.9; 95%C.I. 13.7-18.1], on average, when compared [13.3; 95%C.I. 10.7-15.9] to adults with more variability in DLS scores across conditions.</p><p><strong>Conclusions: </strong>Among ostensibly healthy adults, movement quality was correlated with momentary mindfulness. Additional research is needed to understand if DLS scores are differentially associated with momentary mindfulness among adults with Alzheimer's disease.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251315054"},"PeriodicalIF":3.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of single-session repetitive transcranial magnetic stimulation to identify the optimal brain target in primary progressive aphasia.","authors":"Carlos Moral-Rubio, Paz Suárez-Coalla, Lucia Fernandez-Romero, Carlos Pérez-Izquierdo, Alfonso Delgado-Alvarez, Cristina Delgado-Alonso, Maria Jose Gil-Moreno, Jorge Matias-Guiu, Vanesa Pytel, José L Ayala, Jordi A Matias-Guiu","doi":"10.1177/13872877251315182","DOIUrl":"https://doi.org/10.1177/13872877251315182","url":null,"abstract":"<p><strong>Background: </strong>Non-invasive brain stimulation has shown positive results in maximizing the effects of language therapy in primary progressive aphasia (PPA). Due to the different patterns of brain damage in each aphasia variant, we hypothesized that patients with non-fluent and semantic variants would show a differential response to transcranial magnetic stimulation (TMS).</p><p><strong>Objective: </strong>We aimed to compare the clinical responses after a single session of repetitive TMS in the left inferior frontal gyrus (IFG) and the left dorsolateral prefrontal cortex (DLPC).</p><p><strong>Methodology: </strong>Twenty patients with PPA (14 with non-fluent and 6 with semantic variants) were assessed before and after repetitive TMS over the IFG, DLPC, and vertex with several language tasks, connected speech, and a subjective impression of change scale.</p><p><strong>Results: </strong>IFG stimulation was associated with an improvement in words per minute and the subjective assessment in the non-fluent variant, but no effects were found in the semantic variant. DLPC stimulation was associated with an improvement in words per minute, repetition, and naming latency in the non-fluent variant, and in naming and subjective impression of change in the semantic variant.</p><p><strong>Conclusions: </strong>Our study showed a differential effect of one session of brain stimulation over the IFG and DLPC in patients with non-fluent and semantic PPA variants. These findings suggest that the selection of the target of stimulation may be relevant for the success of brain stimulation and favor the use of DLPC over the IFG.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251315182"},"PeriodicalIF":3.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial electrical stimulation as a therapeutic strategy for Alzheimer's disease: Current uses and challenges.","authors":"Huan Wang, Ning Qin, Dilinuer Maimaitiaili, Jiali Wu, Shuangqin Wang, Yixin Zhou, Jingjue Lu, Yuanli Li","doi":"10.1177/13872877251315777","DOIUrl":"https://doi.org/10.1177/13872877251315777","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is an age-related neurodegenerative disorder for which there are currently rarely effective drug treatments available to halt or slow down its progression. With the aging of the world population, AD as the primary cause of dementia, is rapidly becoming one of the most expensive, lethal, and burdening diseases of this century. In recent years, the new method used to treat nervous system diseases including AD is transcranial electrical stimulation (tES) with non-invasive and for regulating the flexibility of neural circuits operation and behaviors. The rationale of tES for AD neuromodulation is derived from research on animal and clinical trials. In the present paper, we review the current uses of the tES including transcranial direct current stimulation, transcranial alternating current stimulation, and transcranial pulsed electrical stimulation in rehabilitation for AD's core clinical symptom with cognitive dysfunctions, as well as the relevant data from AD animal models have also been discussed. Finally, the regarding applied challenges of tES in AD therapy have been referred for further improvement.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251315777"},"PeriodicalIF":3.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily fluid intake and brain amyloid deposition: A cohort study.","authors":"Jee Wook Kim, Min Soo Byun, Dahyun Yi, Joon Hyung Jung, Nayeong Kong, Yoon Young Chang, Gijung Jung, Hyejin Ahn, Jun-Young Lee, Koung Mi Kang, Chul-Ho Sohn, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee","doi":"10.1177/13872877251314176","DOIUrl":"10.1177/13872877251314176","url":null,"abstract":"<p><strong>Background: </strong>Little information is yet available for the association between daily water intake, a modifiable lifestyle factor, and Alzheimer's disease (AD) pathology and cerebrovascular injury in the living human brain.</p><p><strong>Objective: </strong>Our aim was to explore the correlation between daily fluid intake and in vivo AD pathologies (i.e., amyloid-β (Aβ) and tau) and cerebrovascular injury.</p><p><strong>Methods: </strong>287 cognitively normal (CN) older adults completed extensive clinical assessments, daily fluid intake evaluations, and multimodal brain imaging at both the initial baseline and the subsequent 2-year follow-up.</p><p><strong>Results: </strong>Low daily fluid intake was significantly associated with a higher level or a more rapid increase of Aβ deposition, especially in apolipoprotein E4 negative individuals. Meanwhile, low daily fluid intake was cross-sectionally related with cerebrovascular injury.</p><p><strong>Conclusions: </strong>Our findings suggest that high daily fluid intake is associated with decreased brain amyloid deposition, indicating that sufficient daily fluid intake may be helpful for prevention of AD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251314176"},"PeriodicalIF":3.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic colocalization of cathepsins H, D, and L1 with Alzheimer's disease: Implications for biomarker and therapeutic target discovery.","authors":"Yu-Ting Dong, Xiao Luo, Li-Li Zhang, Yi-Meng Gong, Dan Wang, Dong-Ling Zhong, Yu-Xi Li, Xiao-Min Ma, Rong-Jiang Jin, Juan Li","doi":"10.1177/13872877251314058","DOIUrl":"https://doi.org/10.1177/13872877251314058","url":null,"abstract":"<p><strong>Background: </strong>Cathepsins, a family of lysosomal proteases, have been implicated in Alzheimer's disease (AD) pathogenesis through their involvement in amyloid-β protein precursor processing and neuroinflammation. However, the specific roles of different cathepsins in AD remain unclear.</p><p><strong>Objective: </strong>This study aimed to investigate the genetic associations and potential causal relationships between cathepsins and AD, using Mendelian randomization (MR) to explore their roles as biomarkers and therapeutic targets.</p><p><strong>Methods: </strong>A two-sample MR analysis was conducted using genome-wide association study data for AD and cathepsins. Genetic variants associated with cathepsin expression were used as instrumental variables. Forward MR assessed the causal effect of cathepsins on AD, while reverse MR explored the impact of AD on cathepsin levels. Colocalization analysis was performed to identify shared genetic variants between cathepsins and AD.</p><p><strong>Results: </strong>Cathepsin H was significantly associated with an increased risk of AD (p = 0.0034, OR = 1.04), with consistent results across multiple MR methods. Colocalization analysis revealed a significant genetic overlap between Cathepsin L1 and AD (PP.H4 = 100%), suggesting a shared genetic basis.</p><p><strong>Conclusions: </strong>Cathepsin H may be a potential risk factor for AD, while Cathepsin L1 shows promise as a therapeutic target and biomarker due to its genetic overlap with AD. Further research is needed to explore the mechanisms by which these cathepsins influence AD progression and to assess their therapeutic potential in diverse populations.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251314058"},"PeriodicalIF":3.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid cognitive assessment: Accuracy and discriminant validity of Mini-Cog and process-based Clock Drawing Test.","authors":"Qian Yang, Hao Yang, Wei Long, Sheng Zuo, Defa Zhu, Qihao Guo","doi":"10.1177/13872877251314788","DOIUrl":"https://doi.org/10.1177/13872877251314788","url":null,"abstract":"<p><strong>Background: </strong>The Mini-Cog is a brief cognitive examination comprising a three-item memory recall and a simplified Clock Drawing Test (CDT). There is limited research on the effects of detailed scoring criteria for the Mini-Cog on cognitive screening.</p><p><strong>Objective: </strong>To assess the diagnostic effectiveness of three Mini-Cog versions and a new process-based CDT test in identifying mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to cognitively normal controls (NC).</p><p><strong>Methods: </strong>We prospectively enrolled 950 subjects who underwent standardized neuropsychological assessments and the Mini-Cog test. The CDT was scored using an adapted 10-point scale. The accuracy of three Mini-Cog versions (Mini-Cog1: 3-word delayed recall + 2-point CDT; Mini-Cog2: 3-word immediate recall + 3-word delayed recall + 3-point CDT; Mini-Cog3: 3-word immediate recall + 3-word delayed recall + 10-point CDT) was assessed through the receiver operating characteristic analysis. Sensitivity and specificity were determined for each diagnostic threshold.</p><p><strong>Results: </strong>The optimal cut-off point for Mini-Cog3 is 12/16 for MCI and 10/16 for AD. Mini-Cog3 demonstrated the highest diagnostic efficacy, with AUCs of 0.82 (95% CI: 0.78-0.85) for MCI and 0.95 (95% CI: 0.94-0.97) for AD, with sensitivity of 85% for both MCI and AD. The CDT's AUCs were 0.77 (95% CI: 0.73-0.81) for MCI, and 0.87 (95% CI: 0.84-0.90) for AD, with sensitivity of 89% for MCI, and 82% for AD.</p><p><strong>Conclusions: </strong>A more elaborate scoring system, such as Mini-Cog3, may serve as an effective screening method for the rapid and accurate detection of cognitive dysfunction in patients with MCI and AD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251314788"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}