Journal of Alzheimer's Disease最新文献_第3页

The relationship between Alzheimer's disease and intracerebral hemorrhage based on Mendelian randomization. 基于孟德尔随机化的阿尔茨海默病与脑出血的关系。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-28 DOI: 10.1177/13872877251323294

Yu Shen, Quirui Nie, WenWen Xiang, Shenjian Chen, Qian Cao, Daojun Hong

{"title":"The relationship between Alzheimer's disease and intracerebral hemorrhage based on Mendelian randomization.","authors":"Yu Shen, Quirui Nie, WenWen Xiang, Shenjian Chen, Qian Cao, Daojun Hong","doi":"10.1177/13872877251323294","DOIUrl":"https://doi.org/10.1177/13872877251323294","url":null,"abstract":"BackgroundTraditional epidemiologic studies suggest that Alzheimer's disease (AD) may be associated with intracerebral hemorrhage (ICH).ObjectiveTo explore whether there is a causal relationship between AD and ICH and the underlying mechanisms involved.MethodsMendelian randomization (MR) approach was used to explore causal relationships. The genetic instrumental variables of the candidate genetic instrumental variable AD were obtained from genome-wide association studies. The inverse variance weighted method was the primary method for MR analysis and meta-analysis. The obtained single nucleotide polymorphisms were analyzed for corresponding genes for subsequent pathway enrichment and protein-protein interaction analysis.ResultsFor the single AD dataset, our MR analysis of the AD datasets versus the ICH datasets revealed a genetically predicted causal relationship between AD and ICH (OR 5.947, 95%CI 1.165-30.356, pIVW = 0.032). In addition, the MR-Egger method and MR-PRESSO method revealed no horizontal pleiotropic effect of AD on the risk of ICH. Meta-analysis of each dataset using IVW revealed a final calculated OR of 1.08 (95%CI 1.02-1.15, p = 0.01). Subsequent pathway enrichment analysis revealed that the corresponding genes were involved mainly in the metabolic process of amyloid-β (Aβ) and negatively regulated Aβ formation. In the PPI network analysis, proteins such as ApoE, SROL1, CLU, ABCA7, and AβPP were found to be closely related and located in the key position of the center.ConclusionsWe verified the causal relationship between AD and ICH via MR, and identified the possible pathological mechanisms involved. We also discovered that Aβ plays an important role in this process.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251323294"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

APOE ε4 influences the dynamic functional connectivity variability and cognitive performance in Alzheimer's disease. APOE ε4影响阿尔茨海默病的动态功能连接变异性和认知能力

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-28 DOI: 10.1177/13872877251322687

ChengBing Gong, WenTing Song, ZhengYang Zhu, Dan Yang, Xiang Zhao, Yun Xu, Hui Zhao

{"title":"APOE ε4 influences the dynamic functional connectivity variability and cognitive performance in Alzheimer's disease.","authors":"ChengBing Gong, WenTing Song, ZhengYang Zhu, Dan Yang, Xiang Zhao, Yun Xu, Hui Zhao","doi":"10.1177/13872877251322687","DOIUrl":"https://doi.org/10.1177/13872877251322687","url":null,"abstract":"BackgroundApolipoprotein E (APOE) ε4 is the most significant genetic risk factor for sporadic Alzheimer's disease (AD). However, its impact on the dynamic changes in resting-state functional connectivity (FC), particularly concerning network formation, interaction, and dissolution over time, remains largely unexplored in AD.ObjectiveThis study aims to explore the effect of APOE ε4 on dynamic FC (dFC) variability and cognitive performance in AD.MethodsWe analyzed the dFC of AD patients, comparing APOE ε4 carriers (n = 33) with non-carriers (n = 41). The whole-brain dFC was assessed by calculating dynamic fractional amplitude of low-frequency fluctuations (dfALFF) and dynamic regional homogeneity (dReHo). To further explore the relationship between cognitive function and dFC in AD patients, we conducted a correlation analysis. Mediation analysis was also performed to determine whether dFC mediates the link between the APOE ε4 and cognitive decline in AD patients.ResultsAD patients carrying the APOE ε4 exhibited more severe cognitive impairment, along with reduced dReHo and dfALFF in both the left and right posterior cerebellar lobes. In these carriers, the dFC analysis showed lower dFC between the left posterior cerebellar lobe and the left middle temporal gyrus, which was positively correlated with executive function and information processing speed. Additionally, mediation analysis indicated that APOE ε4 influences dFC in this brain region, contributing to executive dysfunction in AD.ConclusionsThese findings offer preliminary evidence that APOE ε4 modulates fluctuating communication within the cerebellar lobe and the dFC between the cerebellar lobe and the temporal gyrus in AD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251322687"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal epigenetic modification of lysosome and lipid regulating genes in Alzheimer's disease. 阿尔茨海默病溶酶体和脂质调节基因的异常表观遗传修饰。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-28 DOI: 10.1177/13872877251322955

Tingting Ruan, Yunxiang Ling, Can Wu, Yanfang Niu, Guili Liu, Chunshuang Xu, Zhongyue Lv, Yalan Yuan, Xinkai Zhou, Qinwen Wang, Shujun Xu

{"title":"Abnormal epigenetic modification of lysosome and lipid regulating genes in Alzheimer's disease.","authors":"Tingting Ruan, Yunxiang Ling, Can Wu, Yanfang Niu, Guili Liu, Chunshuang Xu, Zhongyue Lv, Yalan Yuan, Xinkai Zhou, Qinwen Wang, Shujun Xu","doi":"10.1177/13872877251322955","DOIUrl":"https://doi.org/10.1177/13872877251322955","url":null,"abstract":"BackgroundAbnormal lipid metabolism has been identified as a potential pathogenic mechanism of Alzheimer's disease (AD), which might be epigenetically regulated. Lysosomes are critical organelles for lipid metabolism. However, the epigenetic modifications of lysosome and lipid regulating genes remain unclear in AD patients.ObjectiveExplore the role of abnormal epigenetic modifications, especially methylation of lysosome and lipid metabolism-related genes in AD.MethodsMethylation beadchip and MALDI-TOF mass spectrometry were used to detect genome-wide DNA methylation levels and validate key gene methylation, respectively. Clinical data were collected from all participants. Associations between clinical biochemical characteristics and altered DNA methylation in AD patients were analyzed, and a risk factor model of AD was established.Results41 differentially methylated positions (DMPs) corresponding to 33 genes were identified in AD patients, with 18 hypermethylated and 23 hypomethylated positions. Significant alterations were observed in lipid regulating genes (CTNNB1, DGKQ, SLC27A1) and lysosomal transmembrane gene (TMEM175). Clinical analysis revealed that TP, ALB, IB, ADA, ALP, HCY, GLU, TC, BUN, HDL-C, LDL-C, and APOA1 levels were significantly higher in AD patients, whereas A/G and DB levels were lower. TMEM175 hypermethylation was further verified and found to correlate with TC, HDL-C, LDL-C, APOA1, IB, and HCY. The AUC of the AD risk model, which integrated clinical lipid markers and TMEM175 methylation, reached 0.9519 (p < 0.0001).ConclusionsAbnormal epigenetic regulation of lysosomal gene and lipid dyshomeostasis were high-risk factors in AD. Methylation modifications of lysosome and lipid regulating genes might be key processes in AD pathogenesis.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251322955"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of risk of Alzheimer's disease diagnosis and survival based on variation to life experiences used to operationalize cognitive reserve. 根据用于认知储备操作的生活经历的变化，调查阿尔茨海默氏症的诊断和存活风险。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-26 DOI: 10.1177/13872877251326818

Kerry A Howard, Lauren M Massimo, Brian Witrick, Lu Zhang, Sarah F Griffin, Lesley A Ross, Lior Rennert

{"title":"Investigation of risk of Alzheimer's disease diagnosis and survival based on variation to life experiences used to operationalize cognitive reserve.","authors":"Kerry A Howard, Lauren M Massimo, Brian Witrick, Lu Zhang, Sarah F Griffin, Lesley A Ross, Lior Rennert","doi":"10.1177/13872877251326818","DOIUrl":"https://doi.org/10.1177/13872877251326818","url":null,"abstract":"BackgroundAlzheimer's disease dementia (AD) is a debilitating progressive neurodegenerative disease. Life experiences are hypothesized to build cognitive reserve (CR), a theoretical construct associated with delayed onset of AD symptoms. While CR is a key moderator of cognitive decline, operationalization of CR is varied resulting in inconsistencies within the literature.ObjectiveThis study explored the relationship between life experiences used as proxies of CR and risk of AD diagnosis and death following diagnosis.MethodsWe explored results based on 30 different published CR operationalizations, including two standardized questionnaires and an investigator-developed lifecourse indicator. Using data from the Memory and Aging Project, we applied Cox proportional hazard models to evaluate the impact of operationalization on time to outcomes.ResultsHazard ratios, indicating instantaneous risk of AD or death for a standard deviation increase in the CR proxy utilized as a predictor, ranged from 0.80-1.40 for AD diagnosis and 0.80-1.29 for death following diagnosis. Among nine predictors that showed a significant reduction in risk of AD, there was a decrease of between 12% and 20%. Two predictors were associated with reduced risk of death, with 13%-20% reduction, while three predictors were associated with 18%-22% heightened risk of death following diagnosis.ConclusionsModel results were highly sensitive to CR operationalization. Based on the variation in results, composite measures that incorporate multiple lifecourse variables may still be the most comprehensive and faithful representation of CR. Attention to methodology and refining of measurement are needed to make use of CR and promote healthy aging.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251326818"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A polymorphism in the BIN1 gene influences its expression and is associated with the risk of Alzheimer's disease: An integrated analysis. BIN1基因的多态性影响其表达并与阿尔茨海默病的风险相关：一项综合分析

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-26 DOI: 10.1177/13872877251326273

Shitao Wang, Guoshuai Luo, Guangxin Sun, Mengen Zhang, Yaqin Qin, Jinghong Lu, Hui Xu, Zongyou Li

{"title":"A polymorphism in the BIN1 gene influences its expression and is associated with the risk of Alzheimer's disease: An integrated analysis.","authors":"Shitao Wang, Guoshuai Luo, Guangxin Sun, Mengen Zhang, Yaqin Qin, Jinghong Lu, Hui Xu, Zongyou Li","doi":"10.1177/13872877251326273","DOIUrl":"https://doi.org/10.1177/13872877251326273","url":null,"abstract":"BackgroundThe correlation between rs7561528 and the risk of Alzheimer's disease (AD) has been reported with varying results, and the potential mechanism of rs7561528 in influencing AD risk remains unexplored.ObjectiveThis study aims to examine the impact of rs7561528 on AD risk and to investigate its potential mechanism.MethodsThis study initially synthesized previously published data to investigate the correlation between rs7561528 and AD risk. Subsequently, an expression quantitative trait loci analysis was conducted to determine whether rs7561528 modulates the expression of BIN1 in human brain tissue.ResultsOur findings revealed that the rs7561528A allele notably escalates the risk of AD in the Caucasian population (OR = 1.17, 95% CI = 1.07-1.28, I² = 33.5%). Similarly, the rs7561528AG genotype also significantly heightens the risk of AD in the same population (OR = 1.18, 95% CI = 1.05-1.31, I² = 21.7%). Further analysis demonstrated that the combined rs7561528AA + AG genotype substantially amplifies the risk of AD in the Caucasian population (OR = 1.21, 95% CI = 1.08-1.36, I² = 30.0%). Ultimately, we discovered that rs7561528 modulates the expression of BIN1 in human brain tissue.Conclusionsrs7561528 could potentially affect the risk of AD by regulating the expression levels of BIN1 in human brain tissue. This discovery enhances our understanding of novel mechanisms through which rs7561528 may contribute to AD risk.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251326273"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifespan of male and female APP/PS1 and APP^NL-F/NL-F mouse models of Alzheimer's disease. APP/PS1和APPNL-F/NL-F老年痴呆模型雌雄小鼠寿命的研究

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-26 DOI: 10.1177/13872877251325878

Hannah Roberts, Yimin Fang, Kathleen Quinn, Tiarra Hill, Mackenzie R Peck, Andrzej Bartke, Kevin N Hascup, Erin R Hascup

引用次数: 0

Associations between plasma complement C1q and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: The CABLE study. 在认知完整的成人中，血浆补体C1q与阿尔茨海默病病理的脑脊液生物标志物之间的关系：CABLE研究

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-26 DOI: 10.1177/13872877251322808

Rong-Ji Xue, Pei-Yang Gao, Yan-Ming Chen, Ying Liu, Bao-Lin Han, Yi-Ming Huang, Yin-Chu Mi, Rui-Ping Cui, Yu-Jing Lin, Zuo-Teng Wang, Chen-Chen Tan, Ya-Nan Ou, Lan Tan

{"title":"Associations between plasma complement C1q and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: The CABLE study.","authors":"Rong-Ji Xue, Pei-Yang Gao, Yan-Ming Chen, Ying Liu, Bao-Lin Han, Yi-Ming Huang, Yin-Chu Mi, Rui-Ping Cui, Yu-Jing Lin, Zuo-Teng Wang, Chen-Chen Tan, Ya-Nan Ou, Lan Tan","doi":"10.1177/13872877251322808","DOIUrl":"https://doi.org/10.1177/13872877251322808","url":null,"abstract":"BackgroundC1q is a promoter of the classical pathway of complement and its massive expression may be associated with the development of Alzheimer's disease (AD). However, the relationships between C1q and the major pathological challenges, including amyloid-β (Aβ) and tau deposition, remain undetermined in the preclinical AD phase.ObjectiveThis study aims to investigate the connections between plasma C1q and CSF AD biomarkers.MethodsThe cognitively intact participants (N = 1264) from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study were categorized into four groups, including Stage 0 [normal Amyloid-β1-42 (Aβ1-42), Phosphorylated-tau (P-tau) and Total-tau (T-tau)], Stage 1 (abnormal Aβ1-42, but normal P-tau or T-tau), Stage 2 (abnormal Aβ1-42 and abnormal P-tau or T-tau), and suspected non-Alzheimer disease pathology (SNAP) (abnormal P-tau or T-tau, but normal amyloid levels). The changes in plasma C1q levels among these groups and the correlation between C1q levels and cerebrospinal fluid (CSF) AD biomarkers were performed.ResultsThe results demonstrated plasma C1q levels are lower in Stage 0 (p = 0.010) and SNAP (p < 0.001) compared with Stage 1. A significant association between C1q levels and CSF AD pathology, including Aβ1-42 (β = -0.143, p < 0.001), Aβ1-42/Aβ1-40 (β = -0.173, p < 0.001), P-tau/Aβ1-42 (β = 0.156, p < 0.001), and T-tau/Aβ1-42 (β = 0.130, p < 0.001) has been identified.ConclusionsThe current research elucidates a positive correlation between elevated plasma C1q levels and CSF Aβ pathology, with C1q amplifying concomitantly with the pathological and clinical progression of AD.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251322808"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baseline associations of office and ambulatory blood pressure monitoring with cognitive function and dementia prevalence. 办公室和动态血压监测与认知功能和痴呆患病率的基线关联。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-26 DOI: 10.1177/13872877251322400

Jesus D Melgarejo, Dhrumil Patil, Sokratis Charisis, Kristina P Vatcheva, Silvia Mejia-Arango, Luis J Mena, Claudia L Satizabal, Ciro Gaona, Egle Silva, Eron Manusov, Joseph H Lee, Joseph D Terwilliger, Jose Gutierrez, Sudha Seshadri, Gladys E Maestre

{"title":"Baseline associations of office and ambulatory blood pressure monitoring with cognitive function and dementia prevalence.","authors":"Jesus D Melgarejo, Dhrumil Patil, Sokratis Charisis, Kristina P Vatcheva, Silvia Mejia-Arango, Luis J Mena, Claudia L Satizabal, Ciro Gaona, Egle Silva, Eron Manusov, Joseph H Lee, Joseph D Terwilliger, Jose Gutierrez, Sudha Seshadri, Gladys E Maestre","doi":"10.1177/13872877251322400","DOIUrl":"https://doi.org/10.1177/13872877251322400","url":null,"abstract":"BackgroundHigh blood pressure has been associated with dementia prevalence and incident. However, it is unclear the relationship of office and ambulatory BP monitoring with cognitive function and dementia and in particular, it remains unknown whether ambulatory BP variability relates to dementia.ObjectiveTo investigate the associations of office and 24-h blood pressure (BP) with cognitive function and dementia prevalence.MethodsCross-sectional population-based study of 1435 participants aged ≥40 years with office BP/24-h BP, and cognitive assessments (Mini-Mental State Examination [MMSE] and Selective Reminding Test [SRT]). Dementia was diagnosed with a clinical dementia rating ≥1.0. Statistics included logistic and linear regression models.ResultsThe mean age was 63.8 ± 10.3 years old and 995 (69.3%) were women. Out of the 1435 participants, 46 (3.20%) had dementia at baseline. Office and 24-h BP levels were not associated with dementia but with one SRT. Increasing 24-h systolic BP variability was associated with lower MMSE (adjusted mean, -0.08; 95% confidence interval [CI], -0.13, -0.03), and SRT (adjusted means ranged from -0.13 to -0.06; 95% CI ranging from -0.19 to -0.01) scores and 1.48-fold greater odds of dementia (95% CI, 1.09-2.02) regardless of BP level.ConclusionsElevated 24-h BP variability, not the BP level, seems to have a stronger association with lower cognitive function and dementia prevalence. Prospective studies are needed to address whether 24-h BP variability relates to cognitive decline and dementia incidence.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251322400"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of long-term care and pandemic wave on relative risk of COVID-19-related infection, hospitalization and mortality in people living with dementia: A population-based cohort study. 长期护理和大流行浪潮对痴呆症患者covid -19相关感染、住院和死亡率相对风险的影响：一项基于人群的队列研究

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-25 DOI: 10.1177/13872877251319560

Andrea D Olmstead, Shengjie Zhang, Larry Shaver, Fernanda Ewerling, Bonnie Henry, Xibiao Ye

{"title":"Effect of long-term care and pandemic wave on relative risk of COVID-19-related infection, hospitalization and mortality in people living with dementia: A population-based cohort study.","authors":"Andrea D Olmstead, Shengjie Zhang, Larry Shaver, Fernanda Ewerling, Bonnie Henry, Xibiao Ye","doi":"10.1177/13872877251319560","DOIUrl":"https://doi.org/10.1177/13872877251319560","url":null,"abstract":"BackgroundPeople living with dementia (PLWD) are vulnerable to serious COVID-19 illness and death but the contribution of various factors including long-term care (LTC), pandemic wave, hospitalization, comorbidities, and underlying neurological health remains unclear.ObjectiveTo investigate the relative risk of SARS-CoV-2 infection, hospitalization, and mortality (COVID-19 and non-COVID-19) in PLWD compared to those without dementia, by living circumstance and pandemic wave, while controlling for additional risk factors.MethodsA cohort of people 65 and up with dementia, including Alzheimer's disease, was propensity score matched to a control cohort using linked population-level health records. Relative risk of outcomes was estimated using adjusted Cox proportional hazards modelling. The modifying effects of LTC residence and pandemic wave on all outcomes, and of COVID-19-related hospitalization on COVID-19 mortality were investigated.ResultsCompared to controls without dementia, PLWD had higher risk of infection and COVID-19 mortality whether they lived in LTC or not. For PLWD in LTC, relative risk was often reduced or not significantly different when stratified by wave but remained higher for PLWD not in LTC (32-93%). In LTC, likelihood of hospitalization was 53-64% lower for PLWD compared to those without dementia. PLWD not hospitalized for COVID-19 had higher COVID-19 mortality than non-hospitalized, non-dementia controls both in and not in LTC (32% and 477%, respectively).ConclusionsPLWD repeatedly had higher risk of COVID-19 infection and mortality, but risk varied with changing pandemic circumstances and living environment. Higher mortality may have been associated with reduced hospital transfers, complex care needs and neurological health.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251319560"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of instrumental activities of daily living in patients with cognitive impairment based on their ability to use household appliances. 基于家用电器使用能力的认知障碍患者日常生活工具活动评估。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-03-25 DOI: 10.1177/13872877251320668

Momoyo Shimosaka, Hiroyuki Nishimoto, Sayaka Okahashi, Derong Zeng, Kayoko Fukui, Teruaki Kawasaki, Ichiro Akiguchi, Ayae Kinoshita

{"title":"Assessment of instrumental activities of daily living in patients with cognitive impairment based on their ability to use household appliances.","authors":"Momoyo Shimosaka, Hiroyuki Nishimoto, Sayaka Okahashi, Derong Zeng, Kayoko Fukui, Teruaki Kawasaki, Ichiro Akiguchi, Ayae Kinoshita","doi":"10.1177/13872877251320668","DOIUrl":"https://doi.org/10.1177/13872877251320668","url":null,"abstract":"BackgroundDetecting life disability is crucial in diagnosing dementia; however, early detection has proven challenging with previous assessment scales. This study focused on an individual's ability to use household appliances as a means of detecting life disability.ObjectiveThe objectives of this study are threefold: (1) to compare the ability to use household appliances between the non-dementia and dementia groups, (2) to determine whether the level of life disability based on the ability to use appliances is at the level of diagnosed dementia or non-dementia, and (3) to explore the impact of age and gender on the ability to use appliances.MethodsWe selected 13 essential household appliances for elderly individuals and proposed an instrumental activities of daily living (IADL) assessment tool to evaluate their usage. Our sample consisted of 98 patients with cognitive impairment, divided into a non-dementia group (N = 34) and a dementia group (N = 64). Most participants in the dementia group had Alzheimer's disease or related conditions. Through multiple logistic regression, the model equation aimed to determine whether a subject's functional disability indicated a potential dementia diagnosis.ResultsThe optimal model equation identified the microwave oven and air conditioner as key factors, achieving an area under the curve (AUC) of 0.78. Additionally, analysis by age and gender enhanced the discriminative power of the results.ConclusionsOur proposed scoring system can efficiently determine the degree of life disability by assessing appliance usage, demonstrating comparable discriminatory ability to existing scales.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251320668"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0