Journal of Alzheimer's Disease最新文献_第3页

Klotho protein in Alzheimer's disease: Diet leading to immortality? 阿尔茨海默病中的Klotho蛋白：饮食导致长生不老？

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 DOI: 10.1177/13872877251350125

Kamil Walczak, Weronika Kołodziejczyk, Magdalena Pszczołowska, Magdalena Kozłowska, Jan Aleksander Beszłej, Jerzy Leszek

{"title":"Klotho protein in Alzheimer's disease: Diet leading to immortality?","authors":"Kamil Walczak, Weronika Kołodziejczyk, Magdalena Pszczołowska, Magdalena Kozłowska, Jan Aleksander Beszłej, Jerzy Leszek","doi":"10.1177/13872877251350125","DOIUrl":"https://doi.org/10.1177/13872877251350125","url":null,"abstract":"Alzheimer's disease (AD) is the most common cause of dementia, leading to progressive cognitive decline and premature death. Despite decades of research, the exact cause of AD remains unknown, and current treatments only slow disease progression without addressing its root cause. Recent studies suggest that endogenous factors such as the Klotho protein may have neuroprotective properties and influence AD progression. This review aims to explore the role of Klotho protein in AD, with a particular focus on its biological functions, expression, and potential therapeutic implications. Additionally, it examines the relationship between Klotho levels and dietary patterns. A literature review was conducted to analyze existing research on Klotho protein, its neuroprotective effects, and its correlation with different dietary factors in the context of AD. Evidence suggests that Klotho protein plays a crucial role in cellular metabolism and neuroprotection. Higher levels of Klotho have been linked to better cognitive function and reduced neurodegeneration. Emerging research also indicates that certain dietary patterns, particularly the Mediterranean diet, may positively influence Klotho expression. Klotho protein represents a promising therapeutic target in AD, potentially slowing disease progression through its neuroprotective effects. Further research is needed to better understand the mechanisms regulating Klotho levels, particularly the impact of diet, and how they can be leveraged for AD prevention and treatment.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251350125"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PTEN inhibition induces neuronal differentiation and neuritogenesis in SH-SY5Y cells via AKT signaling pathway. PTEN抑制通过AKT信号通路诱导SH-SY5Y细胞的神经元分化和神经细胞发生。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 DOI: 10.1177/13872877251352194

Natália Chermont Dos Santos Moreira, Larissa de Oliveira Piassi, Jéssica Ellen Barbosa de Freitas Lima, Geraldo Aleixo Passos, Elza Tiemi Sakamoto-Hojo

{"title":"PTEN inhibition induces neuronal differentiation and neuritogenesis in SH-SY5Y cells via AKT signaling pathway.","authors":"Natália Chermont Dos Santos Moreira, Larissa de Oliveira Piassi, Jéssica Ellen Barbosa de Freitas Lima, Geraldo Aleixo Passos, Elza Tiemi Sakamoto-Hojo","doi":"10.1177/13872877251352194","DOIUrl":"https://doi.org/10.1177/13872877251352194","url":null,"abstract":"BackgroundPTEN is a key regulator of neuronal differentiation and neurogenesis. Its role in modulating the PI3K/AKT pathway and oxidative stress responses in neuronal models remains an area of active investigation.ObjectiveThis study aimed to assess the effects of PTEN knockdown on neuronal differentiation, neuritic growth, and PI3K/AKT pathway activation in SH-SY5Y cells.MethodsSH-SY5Y cells were treated with PTEN siRNA to induce PTEN knockdown. The level of PTEN inhibition was confirmed, and assays were performed to evaluate neurogenesis and neuritogenesis at 3- and 7-days post-treatment. Protein expression analysis of key components in the AKT/GSK3-β/Tau pathway was conducted to assess their role in neurogenesis. Additionally, the PI3K inhibitor LY294002 was used to examine its impact on PTEN knockdown-induced neuronal differentiation.ResultsPTEN knockdown significantly increased neurite lengths and reduced cytoplasmic size, indicating neuronal differentiation. Protein analysis showed that PTEN inhibition modulated the expression of components in the AKT/GSK3-β/Tau pathway. The PI3K inhibitor LY294002 prevented neuronal differentiation, confirming the involvement of the PI3K/AKT pathway in mediating the effects of PTEN knockdown.ConclusionsOur findings demonstrate that PTEN plays a crucial role in regulating neuronal differentiation in SH-SY5Y cells. The PI3K/AKT pathway mediates the effects of PTEN knockdown, suggesting PTEN as a potential therapeutic target for neurodegenerative diseases where its dysregulation may contribute to disease progression.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251352194"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The complementary role of automated brain volumetry to stratify ADNI participants within the ATN framework. 自动脑容量测量在ATN框架内对ADNI参与者分层的补充作用。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-05-13 DOI: 10.1177/13872877251339840

Ilaria Ricchi, Alessandra Griffa, Ricardo Corredor-Jerez, Jonas Richiardi, Jean-François Démonet, Gilles Allali, Bénédicte Maréchal, Olivier Rouaud

{"title":"The complementary role of automated brain volumetry to stratify ADNI participants within the ATN framework.","authors":"Ilaria Ricchi, Alessandra Griffa, Ricardo Corredor-Jerez, Jonas Richiardi, Jean-François Démonet, Gilles Allali, Bénédicte Maréchal, Olivier Rouaud","doi":"10.1177/13872877251339840","DOIUrl":"10.1177/13872877251339840","url":null,"abstract":"BackgroundThe amyloid, tau, neurodegeneration (ATN) framework provides a biological staging model of Alzheimer's disease (AD) using magnetic resonance imaging (MRI), cerebrospinal fluid (CSF), or positron emission tomography (PET) biomarkers. MRI, being non-invasive, accessible, and cost-effective, holds promise as a biomarker.ObjectiveTo evaluate the utility of MRI-based automated brain volumetry in classifying cognitive impairment severity-cognitively unimpaired (CU), mild cognitive impairment (MCI), and dementia-as well as ATN profiles, independently.MethodsWe analyzed 394 subjects from the Alzheimer's Disease Neuroimaging Initiative. First, we assessed how well MRI volumetry stratifies cognitive stages. Next, we tested its ability to distinguish A + T + N+ from A-T-N- individuals while classifying clinical stages. Finally, we evaluated its predictive power for cognitive severity in A + T+ and A-T- subgroups, irrespective of neurodegeneration (N), to examine the added value of volumetry across AT profiles.ResultsMRI volumetry showed comparable performance to established biomarkers in identifying CU, MCI, and dementia, and offered complementary value when combined with phosphorylated tau. Hippocampal and temporal gray matter volumes distinguished A + T + N+ from A-T-N- classes with accuracies of 0.81 and 0.78, respectively. In A + T+ versus A-T- comparisons, the highest classification performance for cognitive severity was observed in the A-T- group.ConclusionsMRI-based brain volumetry can effectively classify cognitive stages and distinguish biological subtypes in AD. It is a promising tool for clinical staging and predicting impairment severity, especially when used alongside phosphorylated tau.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"245-258"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and Alzheimer's disease dementia: Examining inflammatory links to cognitive decline and neuropsychiatric symptoms. 肥胖和阿尔茨海默病痴呆：检查炎症与认知能力下降和神经精神症状的联系。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-05-06 DOI: 10.1177/13872877251338467

Carolin Am Koriath, Robert Perneczky

引用次数: 0

Trends and research focus on autophagy in Alzheimer's disease (2003-2023): A bibliometric study. 自噬在阿尔茨海默病中的趋势和研究重点（2003-2023）：一项文献计量学研究。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-05-06 DOI: 10.1177/13872877251336442

Tianyi Wang, Haochen Jiang, Ruwen Zheng, Chuchu Zhang, Xiumei Ma, Yi Liu

{"title":"Trends and research focus on autophagy in Alzheimer's disease (2003-2023): A bibliometric study.","authors":"Tianyi Wang, Haochen Jiang, Ruwen Zheng, Chuchu Zhang, Xiumei Ma, Yi Liu","doi":"10.1177/13872877251336442","DOIUrl":"10.1177/13872877251336442","url":null,"abstract":"BackgroundAlzheimer's disease (AD) is characterized by amyloid-β plaques and tau aggregates, with autophagy dysfunction playing a key pathogenic role. While autophagy modulation shows therapeutic promise, comprehensive bibliometric analyses are lacking.ObjectiveThis study aims to map the research landscape of autophagy in AD through bibliometric analysis, identifying key trends, contributors, and emerging focus areas.MethodsWe analyzed 4018 publications (2003-2023) from Web of Science using VOSviewer and CiteSpace. Publication trends, influential authors, countries, institutions, and research hotspots were examined through co-occurrence, burst detection, and clustering analyses.ResultsAnnual publications have steadily increased, peaking in 2022. The US led in output and citations, with major contributions from the University of California and New York University. Ralph A. Nixon emerged as the most influential author. Early research (2003-2013) primarily focused on protein degradation mechanisms, whereas recent studies (2014-2023) emphasize mitochondrial dysfunction, apoptosis, and related pathways. Key evolving topics include endoplasmic reticulum stress and chaperone-mediated autophagy, with significant implications for therapeutic innovation.ConclusionsAutophagy plays a critical role in AD pathogenesis and represents a promising therapeutic target. Despite mechanistic advances, clinical translation remains challenging. Future research should prioritize multi-omics integration, drug delivery optimization, and managing risks associated with excessive autophagy activation. These findings provide valuable insights for developing novel AD therapies targeting autophagy.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"5-17"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between dementia symptoms and caregiver and relationship health: A prominent role for speech and language. 痴呆症状与照顾者和关系健康之间的联系：言语和语言的突出作用。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-05-21 DOI: 10.1177/13872877251340578

Robert W Levenson, Jennifer Merrilees, Maya L Henry, Nina F Dronkers

{"title":"Associations between dementia symptoms and caregiver and relationship health: A prominent role for speech and language.","authors":"Robert W Levenson, Jennifer Merrilees, Maya L Henry, Nina F Dronkers","doi":"10.1177/13872877251340578","DOIUrl":"10.1177/13872877251340578","url":null,"abstract":"BackgroundDementia is a significant public health issue globally. People with dementia (PWD) exhibit symptoms in multiple domains (e.g., cognition, emotion, motor, speech/language) that can vary in their impact on the caregiver and the PWD-caregiver relationship.ObjectiveWe assessed the relative impact of various dementia symptoms on caregiver health and well-being and on the PWD-caregiver relationship using a broad sampling of PWD symptoms and caregiver/relationship outcome measures.MethodsData were analyzed from 54 primary caregivers of PWDs who completed seven questionnaires assessing caregiver health and well-being and PWD-caregiver relationship quality. An exploratory factor analysis of these questionnaires revealed two primary factors: (a) General Distress (anxiety, burden, depression, general health, loneliness), and (b) Relationship Quality (interpersonal closeness, relationship satisfaction). Caregivers also rated nine categories of PWD symptoms (memory, executive functions, speech/language, visual/spatial, motor, changes in behavior, sleep, medical/sensory, activities of daily living).ResultsGreater caregiver General Distress was associated with greater PWD speech/language and sleep symptoms. Lower caregiver Relationship Quality was associated (at trend, p < 0.10, levels) with greater PWD speech/language and activities of daily living symptoms. Correlations with the seven individual caregiver outcome measures revealed that speech/language symptoms were the most robust predictors (correlated with five measures), followed by sleep and activities of daily living symptoms (correlated with two measures), and memory, visual/spatial, and motor symptoms (correlated with one measure).ConclusionsFindings highlight the profound adverse effects that PWD speech and language deficits may have on caregivers and underscore the importance of addressing these deficits in dementia care.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"206-217"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated elevation of 181p-tau in the cerebrospinal fluid is associated with distinct clinical features: Findings from a Danish memory clinic cohort. 脑脊液中181p-tau的孤立升高与独特的临床特征相关：来自丹麦记忆诊所队列的研究结果。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-05-06 DOI: 10.1177/13872877251339679

Laura Storm Næsborg Andersen, Anja Hviid Simonsen, Asmus Vogel, Oskar Hoffmann McWilliam, Steen Gregers Hasselbalch, Kristian Steen Frederiksen

{"title":"Isolated elevation of 181p-tau in the cerebrospinal fluid is associated with distinct clinical features: Findings from a Danish memory clinic cohort.","authors":"Laura Storm Næsborg Andersen, Anja Hviid Simonsen, Asmus Vogel, Oskar Hoffmann McWilliam, Steen Gregers Hasselbalch, Kristian Steen Frederiksen","doi":"10.1177/13872877251339679","DOIUrl":"10.1177/13872877251339679","url":null,"abstract":"BackgroundDeposition of amyloid-β and tau are key pathological events in Alzheimer's disease and may be assessed by cerebrospinal fluid (CSF) biomarkers. It remains uncertain whether patients who display abnormal phosphorylated tau in isolation differ from patients with other biomarker profiles.ObjectiveThe primary objective was to investigate differences in demographics, comorbidities, and cognitive performance in amyloid-β negative phosphorylated tau positive patients. Further, the aim was also to investigate the relationship between cognitive function and phosphorylated tau level.MethodsA total of 1049 consecutive patients from the Copenhagen Memory Clinic Cohort from 2018 to August 2022 were included and divided into four groups based on the CSF biomarkers amyloid-β42 (A) and phosphorylated tau (T). Data on co-morbidities, abuse, and neuropsychological tests were recorded, and retrospective data analyses were performed across all groups.ResultsA total of 2.8% participants had an A-T+ biomarker profile and were younger (Mean: 65.1 years, SD: 14.2), comprised of more men (65.5%) than the A + T- group and exhibited both more psychiatric illness (p = 0.027) and alcohol and/or drug abuse (p = 0.004) than the A + T+ group. The A-T+ group performed better on both Addenbrooke's Cognitive Examination (p = 0.002) and Mini-Mental State Examination (p = 0.001) as well as immediate (p = 0.026) and delayed recall (p = 0.009) compared to the A + T+ group but showed no difference compared to the A-T- group on all cognitive scores. Further, higher p-tau levels were associated with worse cognitive performance although effects were small.ConclusionsThe findings indicate that patients with the A-T+ biomarker profile have different clinical characteristic that may indicate a non-neurodegenerative background.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"111-119"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered hemispheres lateralization of brain functional gradients in Alzheimer's disease. 阿尔茨海默病脑功能梯度的半球侧化改变。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-05-22 DOI: 10.1177/13872877251339761

Hao Liu, Yunfei Li, Zheng Sun, Xiaoyu Xu, Bicong Yan, Yuehua Li, Xiaohu Zhao

{"title":"Altered hemispheres lateralization of brain functional gradients in Alzheimer's disease.","authors":"Hao Liu, Yunfei Li, Zheng Sun, Xiaoyu Xu, Bicong Yan, Yuehua Li, Xiaohu Zhao","doi":"10.1177/13872877251339761","DOIUrl":"10.1177/13872877251339761","url":null,"abstract":"BackgroundThe human brain demonstrates intrinsic hemispheric asymmetry across structural, functional, and biochemical domains. While cortical gradients provide a multiscale framework for understanding brain network organization, their hemispheric divergence in Alzheimer's disease (AD) remains unexplored.ObjectiveTo characterize interhemispheric gradient lateralization patterns across the AD continuum and evaluate their clinical correlates.MethodsResting-state fMRI data of 45 normal controls (NC), 45 patients with mild cognitive impairment (MCI), and 45 patients with AD underwent gradient networks processing. Interhemispheric comparisons of mean gradient values were conducted across these groups. A lateralization index (L value) was defined for 17 networks, and differences among the three groups were analyzed using one-way ANOVA. Additionally, correlations between network L values and cognitive scores were examined.ResultsNC and MCI participants exhibited left lateralization of gradient values in the second gradient. In contrast, AD patients showed a loss of interhemispheric lateralization. Notably, AD patients demonstrated reduced lateralization in default mode network (DMN) and control network. The degree of lateralization in DMN was significantly positively correlated with cognitive function.ConclusionsOur findings indicated that patients with AD demonstrated a diminished lateralization in gradient networks. Quantifying gradient laterality may serve as a multimodal biomarker for early AD detection and therapeutic monitoring.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"139-150"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EPRCN exerts neuroprotective function by regulating gut microbiota and restoring gut immune homeostasis in Alzheimer's disease model mice. 在阿尔茨海默病模型小鼠中，EPRCN通过调节肠道菌群和恢复肠道免疫稳态发挥神经保护作用。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-05-05 DOI: 10.1177/13872877251339762

Ming-Jie Li, Meng-Ning Lan, Yao-Xuan Du, Yue Liu, Hua-Yue Zhang, Min Guo, Shi-Wei Liu, Hai-Yang Xia, Zheng-Jun Wu, Hua-Jun Zheng

{"title":"EPRCN exerts neuroprotective function by regulating gut microbiota and restoring gut immune homeostasis in Alzheimer's disease model mice.","authors":"Ming-Jie Li, Meng-Ning Lan, Yao-Xuan Du, Yue Liu, Hua-Yue Zhang, Min Guo, Shi-Wei Liu, Hai-Yang Xia, Zheng-Jun Wu, Hua-Jun Zheng","doi":"10.1177/13872877251339762","DOIUrl":"10.1177/13872877251339762","url":null,"abstract":"BackgroundNo effective drug treatment is currently available for Alzheimer's disease (AD), highlighting the urgent need to develop efficient therapeutic options. We have developed a formula based on medicine and food homology (MFH) consisting of egg yolk oil, perilla seed oil, raphani seed oil, cinnamon oil, and noni puree (EPRCN), and demonstrated that it can treat AD by alleviating neuroinflammation and oxidative stress. However, whether EPRCN can improve AD by regulating gut microbiota remains unknown.ObjectiveThe current study aimed to evaluate the effect of EPRCN on regulating gut microbiota and neuroprotection.Methods16S rRNA sequencing was used to assess the structure of gut microbiota. Hematoxylin-eosin (HE) staining, qRT-PCR, and ELISA were used to evaluate gut inflammation. Detected indexes associated with cholinergic dysfunction and neuronal damage to investigate the neuroprotective effects of EPRCN.Results16S rRNA gene analysis revealed that EPRCN remodeled the gut microbiota, inhibited gut metabolic disorders, and promoted CoA biosynthesis in scopolamine-induced mice. EPRCN can ameliorates gut inflammation by activating the cholinergic anti-inflammatory pathway. The results further indicated that EPRCN improved cholinergic dysfunction by inhibiting the activity of acetylcholinesterase and restoring cholinergic receptors. Additionally, EPRCN administration suppressed the neuronal loss and elevated brain derived neurotrophic factor expression in hippocampus. Correlation analysis found that alteration of several gut microbes was associated with indexes improved by EPRCN.ConclusionsThese findings suggest that EPRCN may serve as a promising dietary intervention for treating AD by regulating the microbiota-gut-brain axis and exerting neuroprotective function.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"151-166"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence-driven natural language processing for identifying linguistic patterns in Alzheimer's disease and mild cognitive impairment: A study of lexical, syntactic, and cohesive features of speech through picture description tasks. 人工智能驱动的自然语言处理用于识别阿尔茨海默病和轻度认知障碍的语言模式：通过图片描述任务研究语音的词汇、句法和衔接特征。

IF 3.4 3区医学

Journal of Alzheimer's Disease Pub Date : 2025-07-01 Epub Date: 2025-05-07 DOI: 10.1177/13872877251339756

Cynthia A Nyongesa, Mike Hogarth, Judy Pa

{"title":"Artificial intelligence-driven natural language processing for identifying linguistic patterns in Alzheimer's disease and mild cognitive impairment: A study of lexical, syntactic, and cohesive features of speech through picture description tasks.","authors":"Cynthia A Nyongesa, Mike Hogarth, Judy Pa","doi":"10.1177/13872877251339756","DOIUrl":"10.1177/13872877251339756","url":null,"abstract":"BackgroundLanguage deficits often occur early in the neurodegenerative process, yet traditional methods frequently fail to detect subtle changes. Natural language processing (NLP) offers a novel approach to identifying linguistic patterns associated with cognitive impairment.ObjectiveWe aimed to analyze linguistic features that differentiate cognitively unimpaired (CU), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups.MethodsData was extracted from picture description tasks performed by 336 participants in the DementiaBank datasets. 53 linguistic features aggregated into 4 categories: lexical, structural, syntactic, and discourse domains, were identified using NLP toolkits. With normal diagnostic cutoffs, cognitive function was evaluated with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).ResultsWith age and education as covariates, ANOVA and post-hoc Tukey's HSD tests revealed that linguistic features such as pronoun usage, syntactic complexity, and lexical sophistication showed significant differences between CU, MCI, and AD groups (p < 0.05). Notably, past tense and personal references were higher in AD than both CU and MCI (p < 0.001), while pronoun usage differed between AD and CU (p < 0.0001). Correlations indicated that higher pronoun rates and lower syntactic complexity were associated with lower MMSE scores and although some features like conjunctions and determiners approached significance, they lacked consistent differentiation.ConclusionsWith the growing adoption of artificial intelligence (AI)-based scribing, these results emphasize the potential of targeted linguistic analysis as a digital biomarker to enable continuous screening for cognitive impairment.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"120-138"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0