Journal of Advances in Medicine and Medical Research最新文献

{"title":"The Influence of the Clinical Pharmacist in the Management of Depression: A Systematic Review","authors":"Bárbara Mendes Paz Chao, Amanda Razera, Maria Fernanda Lopes, Suellen Aparecida Grosko, Amanda Makohin Machado, M. Cordeiro, Luciana Erzinger Alves de Camargo, Catiuscie Cabreira da Silva Tortorella, A. Bini","doi":"10.9734/jammr/2024/v36i25374","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25374","url":null,"abstract":"Background: Mental disorders are among the top ten causes of overload in health systems worldwide. Although traditional pharmaceutical interventions have proven effective in treating depression, the role of the pharmacist in personalized pharmaceutical care for depressed patients is still an emerging area of research and clinical practice, which may be even more effective. \u0000Methods: This study aimed to perform an integrative literature review using the NCBI/PubMed and EMBASE databases, in articles published until the year 2023, according to pre-established inclusion and exclusion criteria. \u0000Results: 360 publications were identified. Following the eligibility criteria, 210 duplicate publications were excluded and 145 were discarded because they did not meet the pre-established eligibility criteria. Thus, 5 original articles from 3 countries were included in the present study. \u0000Conclusion: According to the publications analyzed, it is demonstrated that depression has better response when there is pharmaceutical intervention, as well as multiprofessional. It is noted that factors such as adherence to treatment, control of adverse events related to medications, and quality of life of the patient are directly influenced by the intervention of the clinical pharmacist.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"80 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140451737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing the Bilirubin-Albumin Ratio as a Predictive Marker for Bilirubin-Induced Neurologic Dysfunction: A Comparative Analysis in Two Referral Hospitals in Abeokuta","authors":"Emmanuel Oluwaseun Alaba, I. O. Dedeke, D. D. Agbo","doi":"10.9734/jammr/2024/v36i25373","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25373","url":null,"abstract":"Aim: We aim to assess the predictive value of Bilirubin Albumin Ratio (BAR) for evaluating bilirubin-induced neurologic dysfunction (BIND). Bilirubin-induced neurologic dysfunction is a major cause of morbidity in neonates with highest burden in Sub-Saharan Africa and other resource-limited settings. Bilirubin Albumin Ratio (BAR) has been purported to correlate better with BIND than total serum bilirubin (TSB) which is the conventional tool used in evaluating babies with severe hyperbilirubinemia. There is however paucity of studies utilizing BAR in evaluating BIND. \u0000Study Design: The study design was cross-sectional. \u0000Place and Duration of Study: Neonatal Units of two referral hospitals; Federal Medical Centre Abeokuta and Sacred Heart Hospital Abeokuta in Ogun State, Nigeria between October 2019 – May 2020. \u0000Methods: We included 84 late preterm and term babies with severe hyperbilirubinemia in the first 14 days of life. Babies were grouped into those with and without BIND using the modified BIND score, their sera was assessed for total serum bilirubin, and albumin and the BAR was calculated by dividing the plasma bilirubin level by serum albumin and findings were compared between the two groups. \u0000Results: Bilirubin-induced neurologic dysfunction was present in 67.9% of babies with severe hyperbilirubinemia with a male: female ratio of 1.8:1. The mean BAR for babies with and without BIND were 7.77 ± 1.76 and 5.43 ± 1.27 mg/g respectively. Babies with BIND had a significantly higher BAR than those without BIND (p < .001). Using the receiver operating characteristic curve analysis, the cut-off value for BAR was 6.46 mg/g with sensitivity, and specificity of 84.2% and 81.5% respectively. \u0000Conclusion: The prevalence of BIND among babies with severe hyperbilirubinemia is high and BAR has a high predictive value in evaluating babies at risk of developing BIND.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"89 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus in Pregnancy: The Role of Melatonin","authors":"Gabriela Laste, Jorge de Oliveira Mateus","doi":"10.9734/jammr/2024/v36i25371","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25371","url":null,"abstract":"The effects of COVID-19 on pregnant individuals are unclear due to a series of physiological changes and immune system adaptations that may affect the development of the fetus. There is evidence supporting the role of melatonin in human pregnancy, and it appears that melatonin is essential for a successful pregnancy. However, in pathological conditions, such as during SARS-CoV-2 infection, melatonin levels can be significantly inhibited. In addition, melatonin, a powerful endogen antioxidant, free radical scavenger, and anti-inflammatory molecule, has been reported to exert beneficial effects on viral diseases such as COVID-19. This review focuses on the current evidence regarding the physiopathology of COVID-19 in pregnancy conditions, the role of melatonin during pregnancy, and the use of melatonin as a promising treatment. Addressing these points should help us understand the knowledge currently available about COVID-19 during pregnancy and explore the possible beneficial effects of melatonin. Physiological and immunological adaptations during pregnancy may result in systemic effects that greatly contribute to the development of acute viral infectious diseases such as COVID-19. Melatonin as an adjuvant in COVID-19 treatment has anti-inflammatory, anti-oxidative, and immune response regulatory functions. The strategy that melatonin offers is to slow the cytokine storm observed and reduce oxidative damage to enhance the resistance of individuals and provide additional survival time. Although the direct evidence of melatonin application in COVID-19 is unclear, both its use in experimental animal models and studies on humans has consistently documented its efficacy and safety, and its use by COVID-19 patients would be highly beneficial.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"31 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Functional State of the Adrenal Cortex and Thyroid Gland in Children with Covid-19 during the Recovery Period","authors":"Bobomuratov Turdikul Akramovich, Abdullaeva Mukhlisa Masrurovna","doi":"10.9734/jammr/2024/v36i25372","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25372","url":null,"abstract":"The available literature provides limited data on the demographic and clinical features of SARS-CoV-2 infection in children. This information is especially important because pneumonia is the single leading cause of death in children worldwide. Research in this direction is particularly important to clarify and better understand the global impact of COVID-19 on the pediatric population. Unlike adults, most infected children have a milder course and have better results overall. This article also provides an analysis of the violation of the functional state of the adrenal cortex and thyroid gland in children, features of laboratory and biochemical changes based on a study of the history of the disease in children receiving treatment for coronavirus infection. At the same time, the level of thyroid-stimulating hormone, total T3, total T4 and cortisol in children who had a coronavirus infection was assessed. The last stage demonstrates the prevention and rehabilitation of children after coronavirus infection.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"127 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140454788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Functional Outcome of Arthroscopic Capsular Release in Adhesive Capsulitis (Frozen Shoulder)- A Research Study from North India","authors":"Altaf Hussain, M. Farooq, Sharat Agarwal","doi":"10.9734/jammr/2024/v36i15357","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i15357","url":null,"abstract":"Introduction: Frozen shoulder is a disabling and painful condition that is commonly managed in the primary care setting. Frozen shoulder has a protracted natural history that usually ends in resolution. It is a condition characterised by functional restriction of both active and passive shoulder motion for which radiographs of the glenohumeral joint are essentially unremarkable except for the possible presence of osteopenia or calcific tendonitis. \u0000Aims and Objectives: To evaluate the functional outcome of arthroscopic release of capsule in adhesive capsulitis (frozen shoulder). \u0000Materials and Methods: A prospective study conducted on patients diagnosed as having frozen shoulder. A total of 25 patients were taken who underwent Arthroscopic capsular release. \u0000Results: The mean forward elevation improved from 100.52 to 156.60 at final follow up. Mean abduction improved from 97.12 to 156.36 at final follow up. Mean external rotation 32.76 to 38.96 at final follow up. Mean internal rotation 18.88 to 37.0 at final follow up. The mean UCLA score improved from 13.16 to 32.16 at final follow. Excellent results were seen in 12 patients (48%), Good in 8 patients (32%), Fair in 4 patients (16%) and Poor in 1 patient (4%). \u0000Conclusion: Arthroscopic release of capsule in frozen shoulder (adhesive capsulitis) is a safe and effective procedure with very few complications. It gives further advantage of evaluating any glenohumeral joint and subacromial pathology & rapid rehabilitation is possible in comparison to open procedures.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"9 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139683469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Endodontic Restoration: A Comprehensive Review of Pre and Post Treatment Techniques","authors":"B. S. K. Prasad, Kuchimanchi Sneha Aishwarya","doi":"10.9734/jammr/2024/v36i15352","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i15352","url":null,"abstract":"Endodontic treatments are made much more difficult by the fact that teeth that need them frequently have damaged structures. For these teeth, pre-endodontic restoration is therefore an important strategy that dentists should take into account. Compared to a typical tooth restoration, an endodontic treatment necessitates a more sophisticated restoration because of things like significant cavities, post-treatment root canal dentin, and even the patient's financial situation. It is the dentist's responsibility to repair the tooth and return its shape, functionality, and aesthetics. According to reports, restoration failure—rather than the endodontic treatment itself—is the main reason why endodontic treatments fail. Consequently, the effectiveness of endodontic therapy depends critically on a suitable post-endodontic restoration. Thus the aim of the present paper summarizes on different pre and post endodontic restorative techniques based on the requirement of the case.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"102 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140476355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tackling Infectious Diseases with Special Reference to India: Need for Multidimensional Approach","authors":"Yasmeena Hassan, Ishfaq Majeed Dar, Jahangir Mohi Uddin, Sadaf Saleem, Mohd Younis Rather, A. Waza","doi":"10.9734/jammr/2024/v36i15353","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i15353","url":null,"abstract":"Infectious diseases have long been a major cause for concern since they frequently result in pandemics. Undoubtedly, we have some degree of infection control, but the recent COVID-19 outbreak has reduced us to powerless bystanders watching people perish. The majority of infection-related deaths are caused by respiratory viral diseases, including tuberculosis. The oncovirus as a cause of cancer is a severe health issue that demands attention. The emergence of new harmful forms worsens the problem of infectious diseases. The antigenic profile of pathogens is constantly shifting, which reduces the effectiveness of vaccines or encourages the emergence of medication resistance. The necessity for an all-inclusive strategy is apparent after undertaking a thorough analysis of the scientific knowledge now in existence regarding genesis, transmission, pathophysiology, and availability, as well as the efficacy of medications against infections. There are many grey regions that require attention. For instance, we need to comprehend the biology of the diseases that new infections cause as well as the origin of those infections, the processes and factors that make some hosts vulnerable while others are resistant, the comorbid factors in a population that favours certain infections, and the potential oncogenic viruses of common cancers. We only have a few antimicrobial medicines or vaccines, and many of them are losing their efficacy daily due to bacteria' development of clever neutralizing defences. To find novel therapeutic targets, we must launch a comprehensive research effort. As an alternative, we must go the other way by utilizing passive immunity strategies or researching antiviral medicinal plant products, created chemical analogues, probiotics, and their derived bacteriocins that will demonstrate effective effects against pathogenic bacteria. The action's mechanism can then be understood. As a result, it is imperative that everyone work together to complement one another's skills in order to launch a multifaceted strategy to fill in all the knowledge gaps related to infectious diseases.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"429 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140471982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Study of Organic Compounds from Dipteryx odorata with SARS-COV-2 Targets by Molecular Docking and ADME-TOX Analysis","authors":"Hellen Cris Araújo Souza, Maycon Douglas Araújo Souza, Cássio Silva Sousa, Edilanne Katrine Amparo Viana, Sabrina Kelly Silva Alves, Alex Oliveira Marques, Arthur Serejo Neves Ribeiro, Vanessa de Sousa do Vale, J. A. Rocha","doi":"10.9734/jammr/2024/v36i15351","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i15351","url":null,"abstract":"Introduction: The new coronavirus SARS-CoV-2, identified in December 2019 as the cause of COVID-19, has triggered an outbreak of potentially fatal atypical pneumonia. The constant search for new molecules or strategies to combat this disease continues. Thus, the objective of this work was to evaluate, using in silico methods, the compounds present in Dipteryx odorata as inhibitors of crucial targets of SARS-COV-2. \u0000Methodology: The methodology included the selection of plant compounds from the Pubchem database and obtaining the structures of SARS-COV-2 proteins (6vxx, 6lu7, 1R42) from the Protein Data Bank (PDB). The molecular docking analysis was performed using the Autodock Tools 1.5.6 and Autodock Vina programs, LigPlus to obtain amino acids, and Chimera v.13.1 to generate 3D images. The absorption, distribution, metabolism, excretion and toxicity (ADME-TOX) properties of the most promising compounds were evaluated with the pkCSM tool. \u0000Results: In total, 672 molecular dockings were carried out, tested with 168 ligands, resulting in 17 compounds with binding energies lower than -7.9 kcal.mol-¹. A highlight was the exceptional interaction of the vouacapenic acid compound with the Spike protein, recording an energy of -9.9 kcal.mol-¹. The study revealed that compounds such as vouacapenic acid, taraxasterol and luteolin showed notable interactions with the Spike protein, in addition to positive results in the ADMET-TOX profile. \u0000Conclusion: These findings indicate the potential of these compounds and point to the need for in vivo and in vitro studies to validate their antiviral efficacy as therapeutic agents against SARS-COV-2.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"166 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of Laparoscopic Appendectomy Complications in a Private Hospital in the Northern Region of Brazil, Eastern Amazon","authors":"Fernando Henrique Vasconcelos dos Santos, Ana Caroline Sobrinho Dias, Henrique Acácio Barbosa, Sara Oliveira Rocha, Ana Karoline Kalif Siqueira, Yasmin Hanna Couto Brandão, Rodrigo Hideki Sousa Omoto, Rodrigo Rodrigues Virgolino, Daniele Salgado de Sousa, Janaína M. Cardim, Vitor Hugo Auzier Lima","doi":"10.9734/jammr/2024/v36i15350","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i15350","url":null,"abstract":"Acute appendicitis (AA) is caused by inflammation of the vermiform appendix, with many hypotheses justifying the aetiology of this disease. One of the main aetiologies is obstruction of the appendicular lumen, either by faeces, vegetable seeds, a foreign body or a neoplasm, which increases the luminal pressure of the appendix, with consequent impairment of the vascular supply to the appendicular wall and, therefore, inflammation, necrosis and perforation. Laparoscopic appendectomy is the gold standard surgical procedure currently used for acute appendicitis. It is minimally invasive and has many advantages. Laparoscopic appendectomy has shown a significant advantage over open surgery, as it has the benefit of shorter hospitalisation times, less post-operative pain, a lower rate of complications after surgery and mortality, and lower costs. For this reason, this study aimed to analyse the data obtained on complications associated with laparoscopic appendectomies performed on patients at a private hospital in the northern region between 2020 and 2022. This is an observational, retrospective and descriptive study analysing medical records with a cross-sectional quantitative analysis of the complications of laparoscopic appendectomy. The aim was to describe the main complications in patients undergoing laparoscopic appendectomy and contribute to the scientific framework on the subject.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"41 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Obesity and its Association with Academic Performance and Other Factors among Jazan University Medical Students: A Cross-Sectional Study","authors":"Eman Hurissi, Maram Allami, Altaf Alhazmi, Halimah Alsomaili, Sarah O Gharawi, A. Kamili, Jawahir Homadi, Fadiyah Ageeli, Amirah J. Moafa, A. Abdelmola, Asmaa Zanquti, Abdulaziz H. Alhazmi, Saleh Ghulaysi","doi":"10.9734/jammr/2024/v36i15347","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i15347","url":null,"abstract":"Obesity is a condition when excessive adipose tissue accumulates in the body and that negatively affects health through predisposition to the development of many diseases and complications such as diabetes mellitus, cardiovascular disease, hypertension, and hyperlipidemia. Previous studies reported that obesity could influence the academic performance of the affected individual. Thus, we aimed in this study to measure the prevalence of obesity and its associated risk factors among medical students at Jazan University, and how it could affect academic performance.This is a descriptive, observational cross-sectional study that was conducted on medical students of Jazan University, Saudi Arabia, using questions that assess students’ demographic, academic performance and obesity. Data analyzed using t-test and chi-square test. We included 331 participants, most of them female (74%). About half of the participants have normal weight and recorded a high-grade point average (GPA) of 4 or more (out of 5). The highest GPA (4 or more out of 5) was achieved by 31% of students with normal weight, compared to 12% of underweight, 8% of overweight, and 5% of obese students. Being non-obese is associated with a higher GPA. Further, a significant relationship was observed between obesity and GPA (p-value= 0.013), in which obesity has a negative impact on the GPA of the affected students.In conclusion, our study showed that the medical students at Jazan University with normal weight achieved higher GPAs than other weight groups. We also found that food consumption is increasing with stress in overweight and obese students. This result highlights the importance of prevention measures and awareness to improve academic performance among affected students as obesity has well-known complications.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"24 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}