Journal of Advances in Medicine and Medical Research最新文献

{"title":"Sexuality and Reproductive Health in Adolescence: An Integrative Review","authors":"Jefferson Carlos de Oliveira, Henrique Almeida Assis Costa, Plínio Regino Magalhães, Joana Beatriz de Lima Silva, Marcia Maria Hernandes de Abreu de Oliveira Salgueiro, Abraão Vergasta Reis, Roseane Pereira Jesus Lima, Normelia Santos Oliveira, Lucilia Rocha Lopes Augusto, Maria Luzinete Rodrigues da Silva","doi":"10.9734/jammr/2024/v36i35391","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i35391","url":null,"abstract":"Adolescence is a phase characterized by physical and behavioral changes that impact the sexual and reproductive health of individuals of both genders. While the World Health Organization (WHO) defines adolescence as the period from 10 to 19 years old, in Brazil it is recognized as the age range from 12 to 18 years old. This distinction is important for epidemiological investigations, as well as the development of public policies, social programs, and targeted interventions. This work is grounded in an Integrative Review conducted from August 2019 to October 2019, utilizing electronic databases available in Portuguese, English, and Spanish, including the Latin American and Caribbean Literature on Health Sciences (LILACS), Scientific Electronic Library Online (SCIELO), Nursing Database BDENF, and PubMed. The review process involved several stages: formulating the main research question, selecting articles based on inclusion criteria, excluding irrelevant studies, evaluating the selected articles, interpreting the results, and presenting the integrative review. Through critical analysis of the literature, relevant information was extracted and validated by a researcher. A total of 10 articles were included in this study, sourced from various databases: 5 from VHL, 2 from SciELO, 2 from LILACS, 3 from PubMed, and 3 from BDENF. This study underscores the importance of adopting a clinical practice approach to enhance professional resourcefulness and suggests avenues for future research.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"17 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Effect of Photobiomodulation on pH and Salivary Flow and Its Preliminary Outcome","authors":"Juliana Terra Fernandes, Ana Carolina Santos Menezes Barros, Heloísa Rafaela Lira Ramos dos Reis, Rosana Ferreira dos Santos, Luísa Mazzeo Buchara Iora, Samantha Patrícia Matuck Rocha, Samir Nammour, Aldo Brugnera Júnior, A. Horliana, S. Bussadori, L. Motta","doi":"10.9734/jammr/2024/v36i35383","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i35383","url":null,"abstract":"Xerostomia, a common side effect of radiotherapy, can significantly impact patients' quality of life. This study aimed to compare the immediate effects of infrared light photobiomodulation on salivary flow and pH in individuals experiencing xerostomia. Twenty adults with xerostomia participated in the study, divided into two groups: Group 1 (G1) received extraoral photobiomodulation treatment, and Group 2 (G2) received both intra and extraoral treatment. Stimulated saliva was collected before and immediately after light application. In G1, the photobiomodulation was applied using a cluster (808 nm, 120 mW, 24J), while G2 received treatment with a pointer (808 nm, 100mW, 6J per point). The results confirmed our hypothesis, showing a statistically significant increase in immediate salivary flow stimulation with the headgear technique (G1) (p= 0.037). Analyzing the percentage of volume variation (ml) per minute, the average salivary flow increased from 0.86 ml/min to 1.2 ml/min after extraoral application with an infrared laser cluster, representing a 7% increase. In conclusion, the protocol involving only extraoral application was effective in stimulating salivary flow. Further research is needed to understand the specific mechanisms behind these differences and optimize photobiomodulation techniques for xerostomia management. This study found that using external infrared photobiomodulation can immediately increase salivary flow in xerostomia patients, potentially offering a comfortable and effective symptom management method. It emphasizes the need for refining these techniques and further research to understand long-term effectiveness.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"44 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous Nylon Suture Versus Transcutaneous Skin Stapling for Closure of Midline Incision in Elective Abdominal Surgery: Assessment of Surgical Site Infections and Cosmesis in a Nigerian Tertiary Health Facility","authors":"Omolaiye A. Owolabi, Andrew Dongo, O. Alatise, F. Ogbetere","doi":"10.9734/jammr/2024/v36i35380","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i35380","url":null,"abstract":"Background: Wound closure is as important as any other procedure done by the surgeon. Skin staples are an alternate method to regular sutures in offering an aesthetically acceptable scar in abdominal surgeries. \u0000Objectives: To compare the clinical outcome of staples versus nylon in skin closure of elective midline incision in laparotomy patients in terms of superficial surgical site infection and scar cosmesis. \u0000Materials and methods: This was a prospective comparative hospital-based study. Sixty -six patients who met the criteria were randomized into two equal groups. Group A had their incision closed with skin staples while Group B had their incision closed with nylon suture. The post operative outcomes of the wounds were documented. \u0000Data collection and analysis: A proforma prepared for the purpose of this study was used to collect data. Data analysis was done using the SPSS 22 for windows SPSS Inc. Chicago Illinois. Calculations of mean and standard deviation were done. Associations between variables were tested for statistical significance. For all statistical test p<0.05 was significant. Results were displayed using tables. \u0000Results: There was no superficial surgical site infection in both groups, however scar cosmesis was better in the group A with low mean POSAS total score than group B. \u0000Conclusion: Scar cosmesis was close to normal in group A, with no superficial surgical site infection in elective midline laparotomy incision closure in both groups.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"49 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140434064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology Based Approaches to Enhance Therapeutic Efficacy of Chloroquine and Hydroxychloroquine– A Review","authors":"Vitória Maryana da Silva Borrero, Luiza Regina Voigt, Luciana Oliveira de Fariña, Isabela Angeli de Lima","doi":"10.9734/jammr/2024/v36i35382","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i35382","url":null,"abstract":"Background: Chloroquine (CQ) and hydroxychloroquine (HCQ) are widely used in the treatment of endemic diseases such as malaria and autoimmune conditions like rheumatoid arthritis. Their anti-apoptotic activity, cost-effectiveness, and convenient oral administration make them effective treatments, either as standalone therapies or in combination with other drugs. However, their use is limited by a narrow therapeutic window, which can lead to potential complications due to organ accumulation and non-specific actions in healthy cells. This risk necessitates exploration into safer clinical applications using nanotechnology. \u0000Aim: This scoping review aims to comprehensively assess and analyze the application of nanotechnology to enhance the therapeutic efficacy and safety of CQ and HCQ. \u0000Methods: A meticulous search for original studies on nanoparticle formulations of “chloroquine” and “hydroxychloroquine” was conducted. Two reviewers screened titles and abstracts, followed by a detailed assessment of the full articles. Inclusion criteria encompassed original studies in English, Spanish, or Portuguese, focusing on in vitro, in vivo, and ex vivo evaluations. \u0000Results: After an exhaustive search across selected databases, 30 articles were meticulously chosen for comprehensive evaluation. The most common properties found for nanoparticles included sizes ranging from 100 to 300 nm, a zeta potential lower than -10, with dendritic derivatives being the most encountered types. Materials used in both production and coating varied, influencing the release and specificity of the nanocarrier. Among therapeutic activities, antimalarial and antitumor activities were the most studied. \u0000Conclusion: Studies have demonstrated distinct characteristics acquired by these drugs after encapsulation in various nanoparticles, including reduced toxicity, increased specificity, prolonged systemic circulation, absence of toxic peaks, and potential for different therapeutic approaches.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"42 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140434296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematoma of the Abdominal Sheath Induced by Cough, A Rare Finding in Clinical Practice: A Case Report","authors":"Chin-Chu Wu, A. C. Lin","doi":"10.9734/jammr/2024/v36i35381","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i35381","url":null,"abstract":"We report herein a case of rectus sheath hematoma (RSH) following a cough paroxysm treated as surgical intervention. RSH is a rare clinical condition of acute abdomen and often misdiagnosed in the emergency department. A 67-year-old woman presented to the emergency department with complaint of 2-day history of abdominal pain localized in left upper region. The pain was persistent. The patient reported that her pain worsened with coughing and certain movements. Abdominal muscle forceful contraction during coughing causes direct tear of the rectus muscle or rupture of epigastric arteries leading to formation of RSH, which is the accumulation of blood within anterior rectus abdominis muscle.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"35 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Interventions in the Management of Alport Syndrome: A Systematic Review","authors":"Mohamed Sami, Uchechukwu Christiana Nwankwo, Ome Valentina Akpughe, M. Goshe, Riyotta T. Cutliff, Saanchia Andria Madtha, Nadiya Grynchak, N. L. Ho-Sang, Farzana Rahman, Khudija Nayab, Saeed Razaq, Henry Onyemarim, Kibrom Hailemariam Mesfin, Thitna Surafeal Berhe, Mark Majid Haddad","doi":"10.9734/jammr/2024/v36i35379","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i35379","url":null,"abstract":"Background: Alport syndrome is a genetic disorder primarily affecting the kidney, with significant renal and extrarenal complications. Despite progress in the management of Alport syndrome, effective treatment options are limited. This systematic review aimed to synthesize current evidence regarding potential therapeutic interventions for Alport syndrome. \u0000Methods: A comprehensive literature search was conducted across databases including PubMed, Embase, and Cochrane Library. The eligibility criteria included studies involving patients with Alport syndrome undergoing interventions such as bardoxolone methyl, ramipril, or losartan. Both randomized control trials and non-randomized clinical trials were considered. Key outcomes were changes in renal function parameters and disease progression. Study selection, data extraction, and synthesis were conducted according to standard systematic review guidelines. \u0000Results: A total of 137 studies were identified initially, with four studies meeting the eligibility criteria. These studies collectively included 313 patients with a mean age range of 8.8 to 39.2 years. Three pharmacological interventions were evaluated - bardoxolone methyl, ramipril, and losartan. All demonstrated beneficial impacts on kidney function parameters. Bardoxolone methyl and ramipril showed potential in slowing disease progression, while losartan significantly lowered proteinuria. An additional finding was that the severity of the genetic variant of the disease might impact disease progression and treatment outcomes. \u0000Conclusion: The findings of this systematic review suggest that bardoxolone methyl, ramipril, and losartan may offer promising interventions for managing Alport syndrome, potentially slowing disease progression and improving kidney function. However, the need for larger, more rigorous trials is evident to substantiate these findings and to explore the impact of genetic variant severity on disease progression and treatment response. This review underscores the importance of continued research efforts in improving therapeutic strategies and personalizing treatment for patients with Alport syndrome.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"11 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use and Efficacy of Insulin Eye Drops in Neurotrophic Corneal Ulcers: A Systematic Literature Review","authors":"Ryan Jorge Amorim, José Jesu Sisnando D'Araujo Filho, Cantidio João Silva da trindade Júnior, Tássio Cruz Xavier, Kelly Cristina Costa Guedes Nascimento, Glenda Figueira Guimarães, Evelly Christinne da Silva Moraes, Daniele Salgado de Sousa, Patrick Souza de Alencar, Rodrigo Rodrigues Virgolino, Janaína M. Cardim, Vitor Hugo Auzier Lima","doi":"10.9734/jammr/2024/v36i35378","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i35378","url":null,"abstract":"This research aimed to analyse the use and efficacy of insulin eye drops in the treatment of neurotrophic corneal ulcers by means of a systematic literature review. To this end, relevant studies found in various databases were analysed, including PubMed, Scopus, Science Direct, Scielo, Bireme, Google Scholar and Web of Science. The selected studies were assessed in terms of their objectives, methodology, results and conclusions, with the aim of providing a comprehensive understanding of the current state of evidence on the subject. From the articles by Serrano-Giménez et al. [1], Wang et al. [2] Jaworski et al ([3],  Tong et al. [4], Khilji et al. [5], Moreker et al. [6], Soares et al. [7], CUARTERO-MARTINEZ et al. [8], Lorente-Pascua et al. [9], Erin et al. [10], Diaz-Valle et al [11], Dana et al. [12] and Ruiz-Lozano et al. [13], trends, knowledge gaps and recommendations for clinical practice and future research were identified. As a result, the studies analysed showed a variety of outcomes in relation to the efficacy and safety of insulin eye drops in the treatment of neurotrophic corneal ulcers. There was also a lack of standardisation in the methods used and the evaluation measures, highlighting the need for a more uniform approach in subsequent studies. The main trends identified indicate that insulin eye drops can be effective in treating corneal neurotrophic ulcers, especially in refractory stages. However, there is a need for further research to define more precise diagnostic criteria and more standardised assessment measures. In conclusion, this systematic review has provided a solid basis for future research into the use of insulin eye drops in the treatment of corneal neurotrophic ulcers. The recommendations resulting from this study have the potential to inform clinical practice and guide future research in this field, with the aim of improving these procedures for patients with this specific ophthalmological condition.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical Study of Septal Aperture in Human Humerus in a Population from Southwest Region of Brazil","authors":"Luana Soares De Godoy, Neillyan Mayra Silveira De Carvalho, Vitória Daolio Cruz, B. C. Ferreira-Pileggi, L. N. Watanabe, F. Prado, A. C. Rossi, A. Freire","doi":"10.9734/jammr/2024/v36i35377","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i35377","url":null,"abstract":"Aim: To evaluate the influence of septal aperture (SA) according to sex and side of human skeletons in a sample of the Brazilian population. \u0000Methodology: 103 dried human humeri of both sexes (65 male and 24 female) were used, aged between 18 and 80 years. The morphometry of the SA dimensions was carried out, including the measurement of horizontal diameter and vertical diameter, using a digital caliper. Statistical analysis was performed, considering a significance level of 5%. The ANOVA test (unpaired) was performed to verify whether there was a difference between the sexes (male and female) on each side (right and left). For multiple comparisons, the Tukey test was used. When a normal distribution of data was not found, the Kruskal-Wallis test was performed to evaluate whether there was a difference between the sexes (male and female) on each side (right and left). In this case, for multiple comparisons, the Dunn test was used. \u0000Results: From 103 bones, the SA appeared in 18 bones, regardless of sex and side, resulting in a total incidence of 17.4%. In the general sample, the incidence of SA was 12.6% for males and 4.85% for females. When considering the side, the left side had a higher incidence than the right side, presenting 9.7% and 7.7% respectively. The most common morphological aspect was Oval on both sides and in both sexes. There were no statistical differences regarding morphometry, considering sex and side. \u0000Conclusion: SA is more common in males, on the left side and with an oval morphology in a population from southeastern Brazil.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"358 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Adverse Events: Insights from Health Managers and Strategies to Support Second Victims, in Healthcare Institutions","authors":"Jorge Fernando Dias Vergilio, Karen Ferreira Fernandes Braz, L. D. Sanches, Giseli Cipriano Rodacoski, Elaine Rossi Ribeiro","doi":"10.9734/jammr/2024/v36i25376","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25376","url":null,"abstract":"Introduction: The second victims are the healthcare professionals involved in an unexpected adverse event in patient care. \u0000Aims: To apprehend the perception of healthcare managers regarding the assumptions related to the second victim and understand the strategies adopted by healthcare managers for the support and assistance of the second victim. \u0000Study Design:  This is qualitative research. \u0000Place and Duration of Study: It was conducted in a healthcare institution in the southeastern region of São Paulo, Brazil over a period of two months. \u0000Methodology: The 12 participants were managerial professionals of the institution who responded to a semi-structured interview. The information was analyzed according to Bardin's theoretical framework. \u0000Results: The group of participants consists of managers with different levels of experience, contributing to a diversity of experiences in the field of work, with 83.33% having more than 10 years of professional training. The following categories were apprehended: Safety culture and professional practice, Management and the practice of support, and Healthcare managers and competencies in approaching the second victim. The study highlighted that the second victim management process depends on defining roles and proactive attitudes, involving managers and healthcare professionals, as well as preparing professionals to enhance patient safety and provide appropriate attention to the second victim. \u0000Conclusions: The results suggest, based on the meanings that were apprehended, that the experience of being actors involved in patient safety and adverse events related to the second victim is still in its early stages, and there are paradigms to be shattered and different concepts to be reflected upon. In addition, the institution should prepare its managers and senior management professionals to be welcoming, through continuing education.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"339 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin and Gynecologic Disorders: A Literature Review","authors":"Igor de Oliveira Ferreira, Mariângela Barbon, Júlia Tarter da Rosa, Ana Paula Costella, A. Brietzke, Gabriela Laste","doi":"10.9734/jammr/2024/v36i25375","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i25375","url":null,"abstract":"The present study aimed to review the relevant literature for studies describing the treatment of gynecologic disorders with melatonin, and the clinical relevance of melatonin supplementation in the field of gynecology. We searched the following databases for articles published between 2011 and 2022 that investigated the pathophysiology of the relationship between melatonin and gynecological pathologies in humans: PubMed, MEDLINE, and Embase databases. The 10 included studies primarily focused on the effects of melatonin on patients with polycystic ovarian syndrome (PCOS), as a treatment to reduce pain and improve sleep quality in gynecological pathologies, and as a treatment option for endometriosis. The findings of the present literature review suggested that melatonin can be beneficial in the treatment of PCOS, dysmenorrhea, and endometriosis. The effects of melatonin on MR1A and MR1B receptors, which are present  in the epithelial cells of the endometrial gland, in addition to its known analgesic, anti-inflammatory, and antioxidant properties were also addressed. We concluded that there is a vast field of research on melatonin supplementation and its effects on gynecologic disorders. We also verified the prospects of its use as a therapeutic agent in the auxiliary treatment of gynecological diseases.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"84 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140448079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}