JHEP Reports最新文献

{"title":"Copyright and information","authors":"","doi":"10.1016/S2589-5559(26)00255-7","DOIUrl":"10.1016/S2589-5559(26)00255-7","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101984"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148776527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are FIB-4 and liver stiffness measurement interchangeable for HCC risk stratification in MASLD?","authors":"Yimeng Zhou, Xue Meng","doi":"10.1016/j.jhepr.2026.101852","DOIUrl":"10.1016/j.jhepr.2026.101852","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101852"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes in an international cohort of autoimmune hepatitis","authors":"Yooyun Chung, Meera Garriga, Ilkay Ergenc, Michele Tana, Roxanna A. Irani, Monika Sarkar, Michael A. Heneghan","doi":"10.1016/j.jhepr.2026.101905","DOIUrl":"10.1016/j.jhepr.2026.101905","url":null,"abstract":"<div><h3>Background & Aims</h3><div>Autoimmune hepatitis (AIH) poses challenges in pregnancy, including immunosuppression (IMS) management and risks of adverse pregnancy outcomes. Granular AIH pregnancy data are limited.</div></div><div><h3>Methods</h3><div>This two-center retrospective study included pregnancies in women with AIH at King’s College Hospital and the University of California, San Francisco between 1970 and 2024. Clinical characteristics, IMS regimens and pregnancy outcomes were obtained from chart review. Liver biochemical markers and prognostic scores were assessed as predictive tools for pregnancy outcomes.</div></div><div><h3>Results</h3><div>There were 197 AIH pregnancies in 112 women. AIH pregnancies increased over time (<em>p</em> <0.001). Median age at conception was 29 years. Cirrhosis was present in 43% of pregnancies. IMS was used in 84% of pregnancies. Preconception counseling was provided in 52% of pregnancies and was associated with higher IMS use (61% <em>vs</em>. 31%, <em>p</em> = 0.008). Live birth occurred in 88% of pregnancies, with preterm delivery in 24%. Gestational complications included intrahepatic cholestasis of pregnancy (9%) and preeclampsia (8%). Preterm birth was more common in pregnancies complicated by cirrhosis (33% <em>vs</em>. 16%, <em>p</em> = 0.04), although live birth rates were similar. Loss of biochemical response occurred more frequently postpartum than during pregnancy (25% <em>vs</em>. 6%, <em>p</em> <0.001). The UKELD score was the strongest predictor of live birth (AUROC 0.75), followed by MELD-Na (AUROC 0.73), while preconception AST <33 IU/L predicted maintenance of biochemical response (AUROC 0.65).</div></div><div><h3>Conclusions</h3><div>AIH in pregnancy carries meaningful risks, including a 9% risk of intrahepatic cholestasis and increased preterm birth in women with cirrhosis. Preconception counseling and immunosuppression adherence are associated with favorable outcomes. Preconception UKELD and AST levels may guide individualized risk stratification for live birth and biochemical response.</div></div><div><h3>Impact and implications</h3><div>This large two-center study provides one of the most comprehensive characterizations of autoimmune hepatitis (AIH) in pregnancy, demonstrating high live birth rates but clinically meaningful risks, particularly in women with cirrhosis. It highlights intrahepatic cholestasis of pregnancy and preterm delivery as key complications and shows that disease control and immunosuppression adherence are associated with improved outcomes. Importantly, the study identifies preconception counseling as a modifiable factor linked to better treatment continuation, and introduces UKELD and AST as potential tools for pre-pregnancy risk stratification. These findings support structured preconception care and suggest that validated liver disease scores may help individualise counseling and management in women with AIH considering pregnancy.</div></di","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101905"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Are FIB-4 and liver stiffness measurement interchangeable for HCC risk stratification in MASLD?”","authors":"Georg Semmler, Jan Embacher, Mattias Mandorfer","doi":"10.1016/j.jhepr.2026.101933","DOIUrl":"10.1016/j.jhepr.2026.101933","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101933"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148294183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Comparison of patients with HBV-related HCC with and without MASLD after liver transplantation”","authors":"Chia-Jung Ho, Chun-Ting Ho, Chien-Wei Su","doi":"10.1016/j.jhepr.2026.101944","DOIUrl":"10.1016/j.jhepr.2026.101944","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101944"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial proteomics and cell-cell crosstalk analysis reveal PD-L1 and IL-6 interaction in human primary sclerosing cholangitis","authors":"Giulia Orlandi,&nbsp;Diletta Overi,&nbsp;Rosanna Di Tinco,&nbsp;Alessandra Pisciotta,&nbsp;Giulia Bertani,&nbsp;Sara De Biasi,&nbsp;Stefano Leone,&nbsp;Vincenzo Cardinale,&nbsp;Matteo Franchitto,&nbsp;Selenia Miglietta,&nbsp;Teresa De Luca,&nbsp;Ludovica Ceci,&nbsp;Paolo Onori,&nbsp;Savino Paradiso,&nbsp;Antonio Franchitto,&nbsp;Domenico Alvaro,&nbsp;Guido Carpino,&nbsp;Eugenio Gaudio,&nbsp;Gianluca Carnevale","doi":"10.1016/j.jhepr.2026.101903","DOIUrl":"10.1016/j.jhepr.2026.101903","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Primary sclerosing cholangitis (PSC) is a chronic, immune-mediated cholangiopathy characterized by persistent inflammation and fibrotic remodelling of the biliary tree. We combined spatial proteomics of PSC-affected large bile ducts with a co-culture system of biliary epithelial cells (BECs) and activated peripheral blood mononuclear cells (aPBMCs) to dissect the molecular crosstalk at the epithelial-immune interface.</div></div><div><h3>Methods</h3><div>Spatial proteomic analysis was performed on six PSC-affected bile ducts and five healthy controls by GeoMx® DSP. Single-cell RNA-sequencing analysis from publicly available datasets of human control (n = 22) and PSC-affected (n = 8) livers was performed. We developed an <em>in vitro</em> inflammatory model of PSC by transwell co-culture of BECs (<em>i.e.</em> H69 and primary human biliary tree stem cells) and primary human PBMCs (n = 6). Co-cultures were analysed by transcriptomics on nCounter®, by immunoassays and by culture with/without blocking agents.</div></div><div><h3>Results</h3><div>Peribiliary glands showed higher PD-L1 expression in PSC (score = 1.2 ± 0.4) compared to controls (0.3 ± 0.5; <em>p</em> &lt;0.05), which was associated with apoptosis in neighbouring immune cells on spatial proteomics. <em>In vitro</em>, aPBMCs induced the upregulation of 68 immunoregulatory genes in BECs; PD-L1 and IL-6 upregulation was confirmed at the protein level. BECs induced increased apoptosis in T (CD4⁺/CD8⁺) and NK cells. In co-culture, the exposure of BECs to the IL-6/sIL-6R complex induced significant PD-L1 upregulation (12.7 ± 1.3; <em>p</em> &lt;0.001), which was inhibited by IL-6 receptor blockade (2.6 ± 1.2; <em>p</em> &lt;0.001) or JAK1/2 inhibition.</div></div><div><h3>Conclusions</h3><div>These findings define a critical immunosuppressive axis in PSC driven by BEC-derived IL-6 and PD-L1. Mechanistically, IL-6 acts as an upstream regulator of PD-L1 via JAK/STAT3 and NF-κB signalling, predominantly through IL-6 trans-signalling. This study provides a rationale for targeting epithelial-immune cell interactions as a therapeutic strategy in PSC.</div></div><div><h3>Impact and implications</h3><div>The pathogenic basis of primary sclerosing cholangitis (PSC) is poorly understood, hampering the development of specific therapeutic approaches. We identified IL-6 as a key upstream regulator of PD-L1 via the JAK/STAT3 and NF-κB pathways in biliary epithelial cells, highlighting its central role in regulating epithelial–immune crosstalk during biliary injury. The identification of the PD-L1 pathway in epithelial–immune cell interactions in PSC may improve understanding of the disease, as well as inform the development of therapeutic strategies.</div></div>","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101903"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148054547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of a simple risk stratification for portal hypertension-related clinical deterioration in patients with ascites","authors":"Stefania Gioia,&nbsp;Manuela Merli,&nbsp;Simone Di Cola,&nbsp;Silvia Nardelli","doi":"10.1016/j.jhepr.2026.101829","DOIUrl":"10.1016/j.jhepr.2026.101829","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101829"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of patients with HBV-related HCC with and without MASLD after liver transplantation","authors":"Huigang Li,&nbsp;Jinyan Chen,&nbsp;Chenghao Cao,&nbsp;Shusen Zheng,&nbsp;Xiao Xu,&nbsp;Di Lu","doi":"10.1016/j.jhepr.2026.101877","DOIUrl":"10.1016/j.jhepr.2026.101877","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101877"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional liver imaging score (FLIS): A prognostic biomarker for acute-on-chronic liver failure and liver-related mortality","authors":"Sarah Poetter-Lang,&nbsp;Lorenz Balcar,&nbsp;Ahmed Ba-Ssalamah,&nbsp;Nina Bastati,&nbsp;Raphael Ambros,&nbsp;Antonia Kristic,&nbsp;Julia Krawanja,&nbsp;Katharina Pomej,&nbsp;Benedikt Simbrunner,&nbsp;Georg Semmler,&nbsp;Victor Schmidbauer,&nbsp;Svitlana Pochepnia,&nbsp;Daniel Sobotka,&nbsp;Jacqueline C. Hodge,&nbsp;Ulrike Attenberger,&nbsp;Michael Trauner,&nbsp;Thomas Reiberger,&nbsp;Lucian Beer,&nbsp;Mattias Mandorfer","doi":"10.1016/j.jhepr.2026.101928","DOIUrl":"10.1016/j.jhepr.2026.101928","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>The functional liver imaging score (FLIS; range 0–6, with higher scores indicating better liver function), derived from gadoxetic acid-enhanced MRI, is a prognostic imaging biomarker in advanced chronic liver disease (ACLD). Our aim was to investigate whether semi-quantitative FLIS and quantitative imaging parameters, namely relative liver enhancement (RLE), relative enhancement ratio of the biliary system (REB), and liver-to-portal vein contrast ratio (LPC), predict acute-on-chronic liver failure (ACLF; a syndrome defined by extrahepatic organ failure and high short-term mortality) and liver-related mortality in acute decompensation (AD), the main at-risk population.</div></div><div><h3>Methods</h3><div>We included 210 patients with ACLD who underwent GA-MRI-derived semi-quantitative FLIS assessment, in whom RLE, REB, and LPC were also computed by two independent, experienced radiologists. Patients were stratified into clinically stable ACLD (including compensated or non-acutely decompensated disease) and AD. The prognostic value of semi-quantitative FLIS and quantitative GA-MRI parameters for ACLF/liver-related death was evaluated using competing risk regression analyses, with liver transplantation considered a competing event.</div></div><div><h3>Results</h3><div>FLIS was lower in AD (<em>vs</em>. clinically stable ACLD). Furthermore, low FLIS was an independent risk factor for ACLF development/liver-related death in AD (adjusted subdistribution hazard ratio [aSHR]: 2.37 [95% CI 1.08–5.17], <em>p</em> = 0.031; adjusted for MELD-Na, albumin, and etiological cure), but not in clinically stable ACLD (aSHR: 1.58 [95% CI 0.73–3.45], <em>p</em> = 0.250). Conversely, while RLE, REB, and LPC distinguished between AD and clinically stable ACLD (<em>p</em> &lt;0.001), they did not predict ACLF/liver-related death.</div></div><div><h3>Conclusions</h3><div>The FLIS is a simple prognostic imaging biomarker in acute decompensation that predicts ACLF and liver-related mortality. FLIS-based risk stratification may help identify patients who could benefit from intensified monitoring or timely liver transplant evaluation.</div></div><div><h3>Impact and implications</h3><div>The visual, semi-quantitative functional liver imaging score (FLIS), derived from gadoxetic acid-enhanced MRI, assesses liver function. We found that FLIS predicts acute-on-chronic liver failure and liver-related mortality in patients with acutely decompensated cirrhosis, independent of established risk scores. Conversely, quantitative MRI parameters did not add prognostic value. Thus, FLIS-based risk stratification may help identify patients who could benefit from intensified monitoring or timely liver transplant evaluation.</div></div>","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101928"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hepatocyte-derived GPNMB–RYK signaling axis in MASH progression","authors":"Yuanyuan Fan,&nbsp;Cynthia Ju","doi":"10.1016/j.jhepr.2026.101889","DOIUrl":"10.1016/j.jhepr.2026.101889","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 8","pages":"Article 101889"},"PeriodicalIF":8.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}