JHEP Reports最新文献

{"title":"Corrigendum to ‘B-cell activating factor and IL-21 levels predict treatment response in autoimmune hepatitis’ [J Hepatol (2022) doi: 10.1016/j.jhepr.2022.100460]","authors":"Maaike Biewenga , Sebastiaan Heidt , Manon Vergunst , Camiel J.M. Marijnissen , Rob A. de Man , Annemiek A. van der Eijk , Adriaan J. van der Meer , Leendert A. Trouw , Bart van Hoek","doi":"10.1016/j.jhepr.2025.101447","DOIUrl":"10.1016/j.jhepr.2025.101447","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 7","pages":"Article 101447"},"PeriodicalIF":9.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on opinion paper on the diagnosis and treatment of progressive familial intrahepatic cholestasis","authors":"Emmanuel Gonzales , Richard J. Thompson , Emmanuel Jacquemin","doi":"10.1016/j.jhepr.2025.101361","DOIUrl":"10.1016/j.jhepr.2025.101361","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 6","pages":"Article 101361"},"PeriodicalIF":9.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to ‘Use of artificial intelligence for liver diseases: A survey from the EASL congress 2024’ [JHEP Reports (2024) doi https://doi.org/10.1016/j.jhepr.2024.101209]","authors":"Laura Žigutytė , Thomas Sorz-Nechay , Jan Clusmann , Jakob Nikolas Kather","doi":"10.1016/j.jhepr.2025.101446","DOIUrl":"10.1016/j.jhepr.2025.101446","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 6","pages":"Article 101446"},"PeriodicalIF":9.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copyright and information","authors":"","doi":"10.1016/S2589-5559(25)00139-9","DOIUrl":"10.1016/S2589-5559(25)00139-9","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 6","pages":"Article 101461"},"PeriodicalIF":9.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board page","authors":"","doi":"10.1016/S2589-5559(25)00137-5","DOIUrl":"10.1016/S2589-5559(25)00137-5","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 6","pages":"Article 101459"},"PeriodicalIF":9.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Comment on opinion paper on the diagnosis and treatment of progressive familial intrahepatic cholestasis”","authors":"Patrick McKiernan , Jesus Quintero Bernabeu , Muriel Girard , Giuseppe Indolfi , Eberhard Lurz , Palak Trivedi","doi":"10.1016/j.jhepr.2025.101402","DOIUrl":"10.1016/j.jhepr.2025.101402","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 6","pages":"Article 101402"},"PeriodicalIF":9.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between stage migration and overall survival after radiation-based therapies in patients with hepatocellular carcinoma","authors":"Suraj Pai ,&nbsp;Amit G. Singal ,&nbsp;Shengchen Hao ,&nbsp;Sruthi Yekkaluri ,&nbsp;Anjana Pillai ,&nbsp;Andrew M. Moon ,&nbsp;Ted K. Yanagihara ,&nbsp;Nima Kokabi ,&nbsp;Jane Brown ,&nbsp;Vir J. Kalaria ,&nbsp;Michael C. Mohnasky ,&nbsp;Jonathan Melendez-Torres ,&nbsp;Muhammad M. Tahir ,&nbsp;Aamir Ali ,&nbsp;Muhammad S. Malik ,&nbsp;Isaiah Brown ,&nbsp;Mikin V. Patel ,&nbsp;Jared Christensen ,&nbsp;Theodore Lawrence ,&nbsp;Mishal Mendiratta-Lala ,&nbsp;Neehar D. Parikh","doi":"10.1016/j.jhepr.2025.101434","DOIUrl":"10.1016/j.jhepr.2025.101434","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Stereotactic body radiation therapy (SBRT) and transarterial radioembolization (TARE) are common locoregional therapies for hepatocellular carcinoma (HCC). However, lack of surrogate endpoints has limited the feasibility of conducting comparative effectiveness clinical trials.</div></div><div><h3>Methods</h3><div>We conducted a multicenter retrospective cohort study of adult patients with HCC who received SBRT or TARE as initial treatment between 2008 and 2019. We excluded those with Barcelona Clinic Liver Cancer (BCLC) stage D disease. The primary outcome was overall survival, with transplantation as a competing risk. The independent variable of interest was stage migration to a more advanced BCLC stage (<em>e.g.</em> BCLC stage B → C) within 6 months of treatment. Survival analysis was completed using Kaplan–Meier, and multivariable Cox proportional hazard models were used to identify predictors of survival.</div></div><div><h3>Results</h3><div>We included 257 patients with a median age of 65 years; 77% male and 66% White. Most (75%) had Child–Pugh class A cirrhosis. Stage migration within 6 months was observed in 45 (18%) patients. Patients who experienced stage migration within 6 months of receiving SBRT or TARE had significantly shorter survival than those without stage migration (median 192 days [IQR 108–397 days]) median <em>vs.</em> 1,259 days [IQR 591–2,135 days], respectively; <em>p</em> &lt;0.001). In multivariable analysis, stage migration was significantly associated with worse survival (hazard ratio: 5.1, 95% CI: 4.3–6.0), however the correlation between stage migration and survival was not sufficient for surrogacy. The results were consistent in an independent external validation cohort and in relevant subgroup analyses.</div></div><div><h3>Conclusions</h3><div>Stage migration at 6 months is associated with overall survival in patients with HCC undergoing SBRT or TARE.</div></div><div><h3>Impact and implications</h3><div>Stage migration in patients with receiving hepatocellular carcinoma (HCC) treatment is a multi-faceted measure of tumor function, functional status, and liver function. In this study we were able to show that worsening Barcelona Clinic Liver Cancer stage within 6 months of receipt of radiation treatment is associated with overall survival. Stage migration could be further explored as an endpoint in future clinical trials in patients with HCC receiving radiation therapies.</div></div>","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 7","pages":"Article 101434"},"PeriodicalIF":9.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rifaximin in the spotlight: Are we ready to target the microbiome?","authors":"Florent Artru ,&nbsp;Virginia Hernández-Gea","doi":"10.1016/j.jhepr.2025.101360","DOIUrl":"10.1016/j.jhepr.2025.101360","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 5","pages":"Article 101360"},"PeriodicalIF":9.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Cholangiocarcinoma across England: Temporal changes in incidence, survival and routes to diagnosis by region and level of socioeconomic deprivation’ [JHEP Reports 6 (2024) 100983]","authors":"Daniela Tataru ,&nbsp;Shahid A. Khan ,&nbsp;Roger Hill ,&nbsp;Helen Morement ,&nbsp;Kwok Wong ,&nbsp;Lizz Paley ,&nbsp;Mireille B. Toledano","doi":"10.1016/j.jhepr.2025.101326","DOIUrl":"10.1016/j.jhepr.2025.101326","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 5","pages":"Article 101326"},"PeriodicalIF":9.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “A comment on <Association of physical activity, including amount and maintenance, with the risk of HCC among patients with type 2 diabetes>”","authors":"Mi Na Kim","doi":"10.1016/j.jhepr.2025.101333","DOIUrl":"10.1016/j.jhepr.2025.101333","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 5","pages":"Article 101333"},"PeriodicalIF":9.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}