JHEP Reports最新文献

{"title":"Rifaximin in the spotlight: Are we ready to target the microbiome?","authors":"Florent Artru , Virginia Hernández-Gea","doi":"10.1016/j.jhepr.2025.101360","DOIUrl":"10.1016/j.jhepr.2025.101360","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 5","pages":"Article 101360"},"PeriodicalIF":9.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Cholangiocarcinoma across England: Temporal changes in incidence, survival and routes to diagnosis by region and level of socioeconomic deprivation’ [JHEP Reports 6 (2024) 100983]","authors":"Daniela Tataru , Shahid A. Khan , Roger Hill , Helen Morement , Kwok Wong , Lizz Paley , Mireille B. Toledano","doi":"10.1016/j.jhepr.2025.101326","DOIUrl":"10.1016/j.jhepr.2025.101326","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 5","pages":"Article 101326"},"PeriodicalIF":9.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “A comment on <Association of physical activity, including amount and maintenance, with the risk of HCC among patients with type 2 diabetes>”","authors":"Mi Na Kim","doi":"10.1016/j.jhepr.2025.101333","DOIUrl":"10.1016/j.jhepr.2025.101333","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 5","pages":"Article 101333"},"PeriodicalIF":9.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Changing epidemiology of hepatocellular carcinoma in the Mediterranean area: A challenge for surveillance?”","authors":"Margarita Sala ,&nbsp;María Varela","doi":"10.1016/j.jhepr.2025.101445","DOIUrl":"10.1016/j.jhepr.2025.101445","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 7","pages":"Article 101445"},"PeriodicalIF":9.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copyright and information","authors":"","doi":"10.1016/S2589-5559(25)00119-3","DOIUrl":"10.1016/S2589-5559(25)00119-3","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 5","pages":"Article 101442"},"PeriodicalIF":9.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board page","authors":"","doi":"10.1016/S2589-5559(25)00117-X","DOIUrl":"10.1016/S2589-5559(25)00117-X","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 5","pages":"Article 101440"},"PeriodicalIF":9.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transjugular diagnostic procedures in hepatology: Indications, techniques and interpretation","authors":"Dominik Bettinger ,&nbsp;Annalisa Berzigotti ,&nbsp;Mattias Mandorfer ,&nbsp;Cristina Ripoll ,&nbsp;Christian Labenz ,&nbsp;Eugen Zizer ,&nbsp;Tony Bruns ,&nbsp;Andrea De Gottardi ,&nbsp;Johannes Emrich ,&nbsp;Cornelius Engelmann ,&nbsp;Benjamin Maasoumy ,&nbsp;Arnulf Ferlitsch ,&nbsp;Valentin Fuhrmann ,&nbsp;Jan Hinrichs ,&nbsp;Christian Jansen ,&nbsp;Karoline Lackner ,&nbsp;Robert Matzberger ,&nbsp;Carsten Meyer ,&nbsp;Behrang Mozayani ,&nbsp;Michael Praktiknjo ,&nbsp;Matthias M. Dollinger","doi":"10.1016/j.jhepr.2025.101437","DOIUrl":"10.1016/j.jhepr.2025.101437","url":null,"abstract":"<div><div>Measurement of the hepatic venous pressure gradient (HVPG) and transjugular liver biopsy have emerged as important tools in clinical hepatology. Measurement of HVPG is considered the gold standard for detecting clinically significant portal hypertension, with an HVPG of ≥10 mmHg being the key prognostic threshold in patients with compensated advanced chronic liver disease (cACLD; compensated cirrhosis). A transjugular liver biopsy can be obtained within the same procedure and may be preferred over percutaneous liver biopsy in patients with coagulopathy, ascites and/or significant obesity. Endoscopic ultrasound-guided procedures are currently under investigation and require standardisation. This article summarises critical technical aspects of HVPG measurements and transjugular liver biopsy and provides a detailed overview of their current role in the context of emerging non-invasive tests and endoscopic approaches.</div></div>","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 8","pages":"Article 101437"},"PeriodicalIF":9.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive hepatectomy vs. thermoablation for single small (≤3 cm) hepatocellular carcinoma: A weighted real-life national comparison","authors":"Felice Giuliante ,&nbsp;Simone Famularo ,&nbsp;Sara Grasselli ,&nbsp;Angelo Sangiovanni ,&nbsp;Alessandro Vitale ,&nbsp;Giuseppe Cabibbo ,&nbsp;Andrea Lauterio ,&nbsp;Federica Cipriani ,&nbsp;Alice Saccomandi ,&nbsp;Marco Arru ,&nbsp;Elisa Pinto ,&nbsp;Maurizia Rossana Brunetto ,&nbsp;Maria Stella Franzè ,&nbsp;Camilla Graziosi ,&nbsp;Claudia Campani ,&nbsp;Fabio Marra ,&nbsp;Mariella Di Marco ,&nbsp;Mariarosaria Marseglia ,&nbsp;Valentina Santi ,&nbsp;Mario Capasso ,&nbsp;Francesca Notte","doi":"10.1016/j.jhepr.2025.101420","DOIUrl":"10.1016/j.jhepr.2025.101420","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background &amp; Aims&lt;/h3&gt;&lt;div&gt;For patients with single small (≤3 cm) hepatocellular carcinoma ablation is the first-line treatment, although a high rate of recurrence has been reported. The aim was to compare videolaparoscopic liver resection (laparoscopic resection group) &lt;em&gt;vs.&lt;/em&gt; percutaneous thermoablation (ablation group) in terms of overall survival, recurrence-free survival and early recurrence in a real-life national scenario.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The study is a retrospective collection with subsequent survival analysis. Data were collected from two Italian HCC registries, ITA.LI.CA and HE.RC.O.LE.S. An inverse probability of treatment weighting analysis was performed to balance baseline differences between groups. The Kaplan–Meier method and double-robust Cox multivariable regression were run to estimate the survival and the risk of mortality and recurrence.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Between 2008 and 2022, 1,465 patients were enrolled. The laparoscopic resection group and ablation group consisted of 496 and 969 patients, respectively. At baseline, the ablation group had more advanced liver disease, with higher rates of cirrhosis (90.7% &lt;em&gt;vs.&lt;/em&gt; 77.3%, &lt;em&gt;p&lt;/em&gt; &lt;0.001) and Child-Pugh B status (18.4% &lt;em&gt;vs.&lt;/em&gt; 8.8%, &lt;em&gt;p&lt;/em&gt; &lt;0.001). After a median follow-up of 59 months and after weighting median overall survival was 60 months (95% CI 52–66) for the ablation group and 93 months (95% CI 75–110) for the laparoscopic resection group (hazard ratio [HR] 0.607, 95% CI 0.533–0.691, &lt;em&gt;p&lt;/em&gt; &lt;0.001). Median recurrence-free survival was 26 months (95% CI 23–29) for the ablation group and 39 months (95% CI 30–55) for the laparoscopic resection group (HR 0.736, 95% CI 0.659–0.822, &lt;em&gt;p&lt;/em&gt; = 0.0013). Laparoscopy was associated with a reduced risk of early recurrence (HR 0.747, 95% CI 0.655–0.853, &lt;em&gt;p&lt;/em&gt; = 0.011).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;This study provides real-world evidence that for patients with single ≤3 cm HCC, videolaparoscopic liver resection offers superior long-term oncological outcomes compared with thermoablation. These findings support the preference for surgical treatment in this patient population.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Impact and implications&lt;/h3&gt;&lt;div&gt;Percutaneous thermoablation is considered an appropriate alternative to liver resection for small (≤3 cm) single hepatocellular carcinoma because of not-inferior overall survival, although several authors reported increased recurrence risk. Whether videolaparoscopic liver resection could guarantee comparable survival but superior oncologic control of the disease is a matter of debate. This study comparing videolaparoscopy &lt;em&gt;vs.&lt;/em&gt; thermoablation in a large national cohort of 1,465 patients observed that the former guaranteed significant prolonged OS (93 months [95% CI 75–110] &lt;em&gt;vs.&lt;/em&gt; 60 months [95% CI 52–66] for the ablation group) and recurrence-free survival (26 months [95% CI 23–29] for ablatio","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 8","pages":"Article 101420"},"PeriodicalIF":9.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphatidylethanol and ethyl glucuronide to categorize alcohol consumption in alcohol-related cirrhosis","authors":"Benedict T.K. Vanlerberghe ,&nbsp;Catalina Dumitrascu ,&nbsp;Nele Van den Eede ,&nbsp;Hugo Neels ,&nbsp;Hannah van Malenstein ,&nbsp;Tom J.G. Gevers ,&nbsp;Matthijs Kramer ,&nbsp;Lukas Van Melkebeke ,&nbsp;Ad A.M. Masclee ,&nbsp;Douwe de Boer ,&nbsp;Schalk van der Merwe ,&nbsp;Frederik Nevens ,&nbsp;Alexander L.N. van Nuijs ,&nbsp;Jef Verbeek","doi":"10.1016/j.jhepr.2025.101433","DOIUrl":"10.1016/j.jhepr.2025.101433","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Phosphatidylethanol (PEth) is an alcohol-use biomarker that could bridge the detection windows of urinary ethyl glucuronide (uEtG) and scalp hair ethyl glucuronide (hEtG), but has been rarely validated in patients with liver disease. Reported detection windows of these biomarkers also vary significantly, and available studies have focused solely on any alcohol use. Yet, categorizing patients with liver disease based on their level of alcohol use would be highly informative. Here, we assessed the diagnostic accuracy and optimal detection windows of whole-blood PEth, uEtG, hEtG, and the novel biomarker fingernail ethyl glucuronide (nEtG), for different levels of alcohol use in patients with alcohol-related cirrhosis.</div></div><div><h3>Methods</h3><div>Patients with alcohol-related cirrhosis were questioned on their alcohol use over the previous 3 months using the Alcohol Timeline Followback (n = 116). In addition, 1–7-day (uEtG), 1–5-week (PEth), and 3-month (hEtG and nEtG) detection windows were assessed for any, increased (women ≥2 units/day or men ≥3 units/day), or excessive alcohol use (women ≥5 units/day or men ≥6 units/day).</div></div><div><h3>Results</h3><div>uEtG, PEth, and hEtG had high diagnostic accuracies for any alcohol use at optimal detection windows of 3 days [area under the receiver operating characteristic curve (AUROC): 0.990 (95% confidence interval (CI): 0.975–1.000)], 3 weeks [AUROC: 0.986 (95% CI: 0.958–1.000)], and 3 months [AUROC: 0.925 (95% CI: 0.862–0.987)], respectively. They had high negative predictive values (&gt;92%) for increased and excessive use. nEtG showed promising results for assessing any alcohol use over the previous 3 months [AUROC: 0.962 (95% CI: 0.924–1.000)].</div></div><div><h3>Conclusions</h3><div>PEth and EtG have excellent and complementary diagnostic accuracies to detect any alcohol use and rule out increased alcohol use in patients with alcohol-related cirrhosis. nEtG provides an alternative for hEtG, but requires further validation.</div></div><div><h3>Impact and implications</h3><div>The correct identification and categorization of alcohol use is a major challenge in the treatment of patients with liver disease. Furthermore, given the new nomenclature toward steatotic liver disease, it has become essential to be able to categorize alcohol use into any, increased, or excessive use. The validation of PEth and urine, scalp hair, and nail EtG in patients with alcohol-related liver disease provides us with reliable options to overcome these issues in both clinical care and pharmacological trials on steatotic liver disease.</div></div><div><h3>Clinical Trials registration</h3><div>The study is registered at <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (NCT04363424).</div></div>","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 8","pages":"Article 101433"},"PeriodicalIF":9.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD4 T cells and B cell help – when exhausted cells can still function","authors":"Jill Weisser,&nbsp;Tobias Boettler","doi":"10.1016/j.jhepr.2025.101435","DOIUrl":"10.1016/j.jhepr.2025.101435","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"7 7","pages":"Article 101435"},"PeriodicalIF":9.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}