JHEP Reports最新文献

{"title":"Reply to: “Unaddressed concerns of potential follow-up bias in the International PSC Registry”","authors":"Bregje Mol , Johannes A. Bogaards , Cyriel Y. Ponsioen","doi":"10.1016/j.jhepr.2026.101851","DOIUrl":"10.1016/j.jhepr.2026.101851","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 6","pages":"Article 101851"},"PeriodicalIF":7.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copyright and information","authors":"","doi":"10.1016/S2589-5559(26)00182-5","DOIUrl":"10.1016/S2589-5559(26)00182-5","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 6","pages":"Article 101911"},"PeriodicalIF":7.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148230670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unaddressed concerns of potential follow-up bias in the international PSC registry","authors":"William Shanahan, Eoin Slattery","doi":"10.1016/j.jhepr.2026.101785","DOIUrl":"10.1016/j.jhepr.2026.101785","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 6","pages":"Article 101785"},"PeriodicalIF":7.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board page","authors":"","doi":"10.1016/S2589-5559(26)00180-1","DOIUrl":"10.1016/S2589-5559(26)00180-1","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 6","pages":"Article 101909"},"PeriodicalIF":7.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148231062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board page","authors":"","doi":"10.1016/S2589-5559(26)00151-5","DOIUrl":"10.1016/S2589-5559(26)00151-5","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 5","pages":"Article 101880"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A thioacrylamide-based compound directly counteracts hepatic fibrosis with profound anti-obesity action","authors":"Elisabeth Rohbeck , Corinna Niersmann , Bedair Dewidar , Karl Köhrer , Thorsten Wachtmeister , Bruno Guigas , Volker M. Lauschke , D. Margriet Ouwens , Michael Roden , Juergen Eckel","doi":"10.1016/j.jhepr.2026.101792","DOIUrl":"10.1016/j.jhepr.2026.101792","url":null,"abstract":"<div><h3>Background & Aims</h3><div>Obesity-associated metabolic dysfunction–associated steatotic liver disease (MASLD) and its progression to steatohepatitis (MASH) with advanced fibrosis pose a major global health challenge. Targeting γ-aminobutyric acid (GABA)ergic system has shown promise in mitigating liver injury. Therefore, we investigated HK3, a positive allosteric modulator of the GABA<sub>A</sub> receptor, as a potential therapy for MASH, with a particular focus on liver fibrosis and obesity.</div></div><div><h3>Methods</h3><div>Human-derived 3D MASH spheroids (n = 4-27) and hepatic stellate cells (LX2, n = 3-5) were treated with increasing concentrations of HK3 or its derivative HK1 to assess their anti-steatotic, anti-inflammatory and anti-fibrotic efficacy. Molecular and transcriptional responses were assessed by immunoblotting, ELISA, reverse-transcription PCR and RNA sequencing. The <em>in vivo</em> effects of HK3 (10 or 25 mg/kg) were evaluated in carbon tetrachloride-induced fibrosis (n = 10) or diet-induced obesity (n = 6-7) mouse models. Adipocytes (3T3-L1, n = 5-8) and visceral adipose tissue from C57BL/6 mice (n = 6) were treated with HK3 or HK1 to determine their impact on mitochondrial respiratory function by extracellular flux analysis and high-resolution respirometry.</div></div><div><h3>Results</h3><div>The most effective concentration of HK3 reduced intracellular lipid content, interleukin secretion and pro-collagen 1αI levels (<em>p <</em>0.0001, <em>p <</em>0.05, <em>p <</em>0.01) in the organotypic 3D human MASH model. In hepatic stellate cells, HK3 and HK1 dose-dependently attenuated TGF-β1-induced fibrotic and inflammatory biomarker expression (<em>p <</em>0.0001) and diminished cell migration (<em>p <</em>0.0001). <em>In vivo</em>, HK3 prevented fibrosis progression (<em>p <</em>0.05) in a carbon tetrachloride mouse model and reduced body fat mass (<em>p <</em>0.0001) in a diet-induced obesity mouse model. Accordingly, HK3 increased proton leakage and mitochondrial uncoupling efficiency in adipocytes (<em>p <</em>0.0001) and visceral adipose tissue (<em>p <</em>0.001).</div></div><div><h3>Conclusion</h3><div>HK3 attenuates hepatic fibrosis in preclinical MASH models, while reducing body fat through adipocyte mitochondrial uncoupling. Thus, HK3 offers a promising multi-targeted first-in-class pharmacological approach for obesity-associated MASLD.</div></div><div><h3>Impact and implications</h3><div>Obesity-related fatty liver disease can progress to severe liver scarring, yet effective treatments targeting both liver damage and metabolic dysfunction remain rare. This study investigates HK3, a novel small molecule, which reduced liver fat, inflammation, and scarring while also lowering body fat in multiple preclinical models. These findings are particularly relevant for patients with obesity-related fatty liver disease, where current therapies often fail to adequately address fibrosis,","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 5","pages":"Article 101792"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copyright and information","authors":"","doi":"10.1016/S2589-5559(26)00153-9","DOIUrl":"10.1016/S2589-5559(26)00153-9","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 5","pages":"Article 101882"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative immunotherapy to reduce recurrence in resectable hepatocellular carcinoma - lessons learned from the CARES-009 trial","authors":"Laia Aceituno , Arndt Vogel","doi":"10.1016/j.jhepr.2026.101820","DOIUrl":"10.1016/j.jhepr.2026.101820","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 5","pages":"Article 101820"},"PeriodicalIF":7.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board page","authors":"","doi":"10.1016/S2589-5559(26)00111-4","DOIUrl":"10.1016/S2589-5559(26)00111-4","url":null,"abstract":"","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 4","pages":"Article 101840"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EASL position paper on palliative care in advanced chronic liver disease","authors":"Sumita Verma ,&nbsp;Matthias Pinter ,&nbsp;Lucia Macken ,&nbsp;Patrizia Künzler-Heule ,&nbsp;Lise Lotte Gluud ,&nbsp;Bart Takkenberg ,&nbsp;Rui Nunes ,&nbsp;Liana Gheorghe ,&nbsp;Wendy Prentice ,&nbsp;Ben Hudson","doi":"10.1016/j.jhepr.2025.101686","DOIUrl":"10.1016/j.jhepr.2025.101686","url":null,"abstract":"<div><div>Deaths from advanced chronic liver disease have increased significantly across Europe, with most affected patients not receiving a liver transplant. Despite this increasing burden, inequities in the provision of palliative care persist. Many patients are referred to specialist palliative care only in the final days or weeks of life and may continue to undergo futile invasive procedures. Drawing on the best available evidence, this position paper offers guidance to clinicians on the provision of palliative care to patients with advanced chronic liver disease, with the aim of improving the quality of life of this vulnerable cohort.</div></div>","PeriodicalId":14764,"journal":{"name":"JHEP Reports","volume":"8 4","pages":"Article 101686"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}