Japanese Journal of Oral Biology最新文献_第2页

Functional Characterization of the Receptor Activator of NF-.KAPPA.B(RANK) Extracellular Domain. NF-.KAPPA.B(RANK)胞外结构域受体激活因子的功能表征。

Japanese Journal of Oral Biology Pub Date : 2003-06-20 DOI: 10.2330/JORALBIOSCI1965.45.130

T. Imai, M. Shibata, A. Mizuno, Y. Kato

引用次数: 0

Histopathological Study of Caries and Aging on the Lung Tissue of Rats 大鼠肺组织龋病与衰老的组织病理学研究

Japanese Journal of Oral Biology Pub Date : 2003-06-20 DOI: 10.2330/JORALBIOSCI1965.45.121

K. Kuyama, Yasuto Ohta, S. Fifita, Hirotsugu Yamamoto

引用次数: 1

Overexpression of H-ras and pERK 1/2 Related to Lymph Node Metastasis in Oral Squamous Cell Carcinomas 口腔鳞状细胞癌中H-ras和pERK 1/2过表达与淋巴结转移的关系

Japanese Journal of Oral Biology Pub Date : 2003-06-20 DOI: 10.2330/JORALBIOSCI1965.45.113

Li-hong Wang, K. Kurose, Lin Jia, Huiqou Wang, N. Okada, M. Takagi

{"title":"Overexpression of H-ras and pERK 1/2 Related to Lymph Node Metastasis in Oral Squamous Cell Carcinomas","authors":"Li-hong Wang, K. Kurose, Lin Jia, Huiqou Wang, N. Okada, M. Takagi","doi":"10.2330/JORALBIOSCI1965.45.113","DOIUrl":"https://doi.org/10.2330/JORALBIOSCI1965.45.113","url":null,"abstract":"本研究では, 免疫組織化学方法により, Ras/Raf/MEK/ERKのシグナル伝達経路にあるH-rasおよびpERK 1/2タンパク質の過剰発現, および活性化と口腔扁平上皮癌の転移との関連性について検討した. 口腔扁平上皮癌38症例と正常口腔粘膜上皮17例, 合計55症例を検索対象とした. 口腔扁平上皮癌症例においては, H-rasとpERK 1/2タンパクの発現は, 正常口腔粘膜上皮より高頻度である傾向が認められた (p 0.05). H-rasタンパクの高レベルの発現は, リンパ節転移の有無と有意の関連性があり (p<0.05), リンパ節転移を伴った症例では, H-ras, pERK 1/2のおのおのの単独の発現と比べ, H-rasとpERK 1/2タンパクの共通発現の亢進が高度で, H-rasとpERK 1/2タンパクの両者の発現を示すものが多かった (p<0.05). このことから, Ras/Raf/MEK/ERKのシグナル伝達経路にあるH-ras, pERK 1/2のタンパク質発現は, 口腔扁平上皮癌の悪性度の指標である腫瘍の転移や組織分化度と相関する大きな意義を有していることが示唆された.","PeriodicalId":14631,"journal":{"name":"Japanese Journal of Oral Biology","volume":"11 1","pages":"113-120"},"PeriodicalIF":0.0,"publicationDate":"2003-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87662298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Multifunctional Role of PRIP lnvolved in Dynamic Regulation of GABAA Receptors PRIP在GABAA受体动态调控中的多功能作用

Japanese Journal of Oral Biology Pub Date : 2003-06-20 DOI: 10.2330/JORALBIOSCI1965.45.93

T. Kanematsu

{"title":"Multifunctional Role of PRIP lnvolved in Dynamic Regulation of GABAA Receptors","authors":"T. Kanematsu","doi":"10.2330/JORALBIOSCI1965.45.93","DOIUrl":"https://doi.org/10.2330/JORALBIOSCI1965.45.93","url":null,"abstract":"現代社会の加速度的な技術革新や高度情報化の波は, 現代人にきわめて強いストレスを与え,処方される抗不安薬などの使用量は,増加の一途をたどっているという。現在,臨床で頻用される抗不安薬の1つに,ベンゾジアゼピン系の薬物がある。この薬物は,γ-アミノ酪酸 (GABA)をトランスミッターとする抑制性神経伝達を増強することで,その薬理作用(抗不安作用)を発揮する。またGABA受容体の異常は,不眠・不安・緊張・けいれん・てんかんなどのさまざまな病態を引き起こすことが知られ,GABA受容体の正常な働きは,複雑な脳・精神機能を形成する分子的基盤の重要な一角をなしている。すなわち,GABA受容体を含めた抑制性シナプス構築の分子メカニズムを解明することは,人間の情動・精神活動を理解するうえで非常に重要である。最近,GABAA受容体の構築や輸送にかかわる分子の報告が相次いでおり,その分子基盤を解明する機運が高まっている。われわれは,当教室で発見したイノシトール1,4,5-三リン酸[Ins(1,4,5)P3]結合性タンパク質 (PRIP-1)が,GABAA受容体の情報伝達系を調節する分子でもあることを最近明らかにした。本稿では,PRIP-1 発見からGABAA受容体の構築や輸送にPRIP-1がいかにかかわるか,これまでの知見と今後の展望についてまとめる。新しいタンパク質ファミリー(PRIP)の発見","PeriodicalId":14631,"journal":{"name":"Japanese Journal of Oral Biology","volume":"6 1","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2003-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76899119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Parathyroid Hormone-Related Protein in Intramembranous Bone Formation and Tooth Development and Eruption 甲状旁腺激素相关蛋白在膜内骨形成和牙齿发育及萌出中的作用

Japanese Journal of Oral Biology Pub Date : 2003-06-20 DOI: 10.2330/JORALBIOSCI1965.45.103

N. Suda

{"title":"The Role of Parathyroid Hormone-Related Protein in Intramembranous Bone Formation and Tooth Development and Eruption","authors":"N. Suda","doi":"10.2330/JORALBIOSCI1965.45.103","DOIUrl":"https://doi.org/10.2330/JORALBIOSCI1965.45.103","url":null,"abstract":"副甲状腺ホルモン関連ペプチド(parathyroid hormone-related protein: PTHrP)は,もともと乳がんなどの悪性腫瘍において明らかな骨転移を伴わないにもかかわらず,しばしば併発する高カルシウム血症を引き起こす原因因子として発見され,副甲状腺ホルモン(PTH) との構造上の類似性からこのような命名を受けた1-3)。その後,その遺伝子欠損マウスの四肢と成長板軟骨が著しく短縮することが報告され4,5),軟骨細胞が発現する PTHrPが軟骨細胞自身の分化・増殖や軟骨内骨化の進行制御を担う重要な局所因子であることが明らかとなった4-9)。ところで筆者らは,さまざまな分化段階の骨芽細胞も PTHrPとその主たる受容体であるtype1 PTH/ PTHrP receptorを発現することを報告し10,11),この因子の膜性骨形成における機能に興味をもって研究を続けてきた。また最近,歯(歯胚)の上皮組織がPTHrPを発現することが報告され12-14),その生理的意義が注目されている。本稿ではこれらの点について,筆者らがこれまで詳細に行ってきたPTHrP遺伝子欠損マウスの解析9,15-22)を中心に論じていく。骨芽細胞のPTHrP発現","PeriodicalId":14631,"journal":{"name":"Japanese Journal of Oral Biology","volume":"71 1","pages":"103-112"},"PeriodicalIF":0.0,"publicationDate":"2003-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80747895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Human Saliva on the Formation of Calcium Phosphate Precipitates in the Presence of Glycyrrhiza and Tannic Acid 在甘草酸和单宁酸存在下，人唾液对磷酸钙沉淀形成的影响

Japanese Journal of Oral Biology Pub Date : 2003-04-20 DOI: 10.2330/JORALBIOSCI1965.45.64

S. Hidaka

引用次数: 4

Relationship between Physical Properties of a Food Bolus and Initiation of Swallowing 食物丸的物理性质与开始吞咽的关系

Japanese Journal of Oral Biology Pub Date : 2003-04-20 DOI: 10.2330/JORALBIOSCI1965.45.59

K. Shiozawa, K. Kohyama, K. Yanagisawa

{"title":"Relationship between Physical Properties of a Food Bolus and Initiation of Swallowing","authors":"K. Shiozawa, K. Kohyama, K. Yanagisawa","doi":"10.2330/JORALBIOSCI1965.45.59","DOIUrl":"https://doi.org/10.2330/JORALBIOSCI1965.45.59","url":null,"abstract":"To clarify the relationship between the physical properties of a food bolus and the initiation of swallowing, we measured the texture of food boluses collected from the oral cavity at three different stages of mastication: M stage, the halfway stage of mastication; L stage, immediately prior to swallowing; and +20% stage, the number of chewing strokes 20% beyond a point at which swallowing would usually occur. Eleven healthy adult participants masticated highly adhesive rice cakes (RC), hard and brittle peanuts (P) and hard biscuits (HB). The texture of the bolus was measured by texture profile analysis. Hardness of the bolus decreased significantly from the M to L stage during mastication of all three types of food. This finding suggests that the decrease in hardness of a bolus may be a necessary factor for the initiation of swallowing, although it is not a sufficient factor by itself for the initiation of swallowing. For both the P and HB boluses, adhesiveness had a maximum value at the L stage immediately prior to swallowing, and cohesiveness increased significantly from the M to L stage. In contrast, adhesiveness of the RC bolus decreased significantly (p<0.001) from the M to L stage, with cohesiveness remaining unchanged. These findings suggest that the initiation of swallowing during mastication of hard and brittle food commences once a clump bolus formed, while swallowing of highly adhesive food is triggered when adhesiveness of the bolus is sufficiently reduced to meet the swallowing threshold.","PeriodicalId":14631,"journal":{"name":"Japanese Journal of Oral Biology","volume":"18 1","pages":"59-63"},"PeriodicalIF":0.0,"publicationDate":"2003-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82445864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Localization of Ebk/MDK1 in Mouse Oral Development Ebk/MDK1在小鼠口腔发育中的定位

Japanese Journal of Oral Biology Pub Date : 2003-04-20 DOI: 10.2330/JORALBIOSCI1965.45.52

Takehiko Shimizu, T. Maeda

引用次数: 0

Proteomic Analysis of Protein Expressed in Odontoblastic Differentiation of Bovine Dental Pulp Cells 牛牙髓细胞成牙细胞分化过程中蛋白表达的蛋白质组学分析

Japanese Journal of Oral Biology Pub Date : 2003-02-20 DOI: 10.2330/JORALBIOSCI1965.45.1

S. Fujiwara, K. Imai, M. Seiki, K. Sanada

引用次数: 1

Effects of Long-term Oral Administration of Fluoride on the Physico-chemical Properties of Porcine Bone Mineral: Comparison between Cortical and Trabecular Bones 长期口服氟化物对猪骨矿物质理化性质的影响:皮质骨和小梁骨的比较

Japanese Journal of Oral Biology Pub Date : 2003-02-20 DOI: 10.2330/JORALBIOSCI1965.45.16

Teruhisa Iidaka, H. Yagishita, A. Richards, O. Fejerskov

引用次数: 0