Iranian Journal of Otorhinolaryngology最新文献_第6页

Evaluation of Nasal Obstruction Following Septoturbinoplasty Using the VAS and NOSE Scale. 使用 VAS 和 NOSE 量表评估鼻塞成形术后的鼻腔阻塞情况

Iranian Journal of Otorhinolaryngology Pub Date : 2024-01-01 DOI: 10.22038/IJORL.2023.75824.3541

Esteban Merino-Galvez, Javier Gómez-Hervás

{"title":"Evaluation of Nasal Obstruction Following Septoturbinoplasty Using the VAS and NOSE Scale.","authors":"Esteban Merino-Galvez, Javier Gómez-Hervás","doi":"10.22038/IJORL.2023.75824.3541","DOIUrl":"10.22038/IJORL.2023.75824.3541","url":null,"abstract":"Introduction: Patient satisfaction with septoturbinoplasty was measured using the subjective visual analogue scale (VAS) and Nasal Obstruction Symptom Evaluation (NOSE) scale. In addition, those factors that impacted satisfaction were confirmed.Materials and methods: We conducted an observational study of patients who underwent septoturbinoplasty. Age, sex, smoking habit, duration of improvement, postoperative complications, type of packing and surgeon were analysed. The results were compared using the VAS and NOSE scale.Results: The improvement experienced with surgery corresponded to 69.80±26.97 points on the VAS 42.65±22.9 points (p <0.01) on the NOSE scale. A strong, direct correlation between the two scales (r = 0.79; p <0.01) was achieved. Surgeon, presence of complications, smoking habit and type of packing were not associated with the improvement experienced on the VAS or NOSE scale. Patients under 30 years of age and patients with permanent improvement achieved higher levels of satisfaction on both scales (p <0.01). Women showed a stronger tendency to perceive their improvement as temporary (p <0.01).Conclusions: Patients who underwent septoturbinoplasty experienced a subjectively measured improvement in nasal obstruction. The VAS and the NOSE scale were strongly correlated with one another. Sex, age and duration of improvement (temporary versus permanent) impacted patient perception; surgeon, smoking habit and type of packing did not.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"36 1","pages":"335-342"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10800140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139520951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Outcomes of Cochlear Implantation in Patients with Solid Organ Transplant. 实体器官移植患者人工耳蜗植入术的效果。

Iranian Journal of Otorhinolaryngology Pub Date : 2024-01-01 DOI: 10.22038/ijorl.2024.76676.3571

Seyed Basir Hashemi, Leila Monshizadeh, Tayebeh Kazemi, Seyed Reza Cheraghzadeh, Seyed Ali Malek-Hosseini

{"title":"The Outcomes of Cochlear Implantation in Patients with Solid Organ Transplant.","authors":"Seyed Basir Hashemi, Leila Monshizadeh, Tayebeh Kazemi, Seyed Reza Cheraghzadeh, Seyed Ali Malek-Hosseini","doi":"10.22038/ijorl.2024.76676.3571","DOIUrl":"10.22038/ijorl.2024.76676.3571","url":null,"abstract":"Introduction: As far as it is known, long-lasting immunosuppressive therapy might put patients with solid organ transplantation (SOT) at increased risk for severe to profound sensorineural hearing loss, eventually leading to cochlear implantation (C.I). So, the main aim of the present study is to evaluate their auditory perception performance after cochlear implantation.Materials and methods: This case-series study assessed the auditory perception performance of our center's six cochlear-implanted patients who had undergone solid organ transplantation before. The patients' age range was between 3 to 68 years old. Two participants (Female/ male) had received liver transplantation, and the rest (two males and two females) had undergone kidney transplantation. The assessment was conducted through the CAP (Categories of Auditory Performance) test in the first month of cochlear implantation and 12 months later.Results: Except for one patient (A 3-year-old girl) who has recently received a cochlear implantation device, and her rehabilitation program is in progress, the auditory perception performance of others improved from 2 to at least six scores. Also, no wound infection, mastoiditis, or bacterial meningitis occurred after cochlear implantation.Conclusion: Immunosuppressive therapy, hemodialysis, infections, and long-lasting medication might lead to severe to profound sensory neural hearing loss in organ-transplanted patients. In recent years, cochlear implantation has been considered a final solution to help this group of patients to hear and communicate better.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"36 6","pages":"663-667"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Deleterious MYO15A Gene Mutation Causes Nonsyndromic Hearing Loss. 一种新型致畸 MYO15A 基因突变导致非综合征性听力损失。

Iranian Journal of Otorhinolaryngology Pub Date : 2024-01-01 DOI: 10.22038/IJORL.2023.69889.3372

Mostafa Neissi, Adnan Issa Al-Badran, Javad Mohammadi-Asl

引用次数: 0

The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis. 三种局部皮质类固醇对鼻窦息肉病的影响

Iranian Journal of Otorhinolaryngology Pub Date : 2024-01-01 DOI: 10.22038/IJORL.2023.75247.3524

Matin Ghazizadeh, Ali Goljanian Tabrizi, Najmeh Rajabi

{"title":"The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis.","authors":"Matin Ghazizadeh, Ali Goljanian Tabrizi, Najmeh Rajabi","doi":"10.22038/IJORL.2023.75247.3524","DOIUrl":"10.22038/IJORL.2023.75247.3524","url":null,"abstract":"Introduction: Since sinonasal polyposis (SNP) has a high recurrence rate after surgery, various studies have investigated the effect of corticosteroid medications to prevent disease recurrence. The present study was designed to compare the effect of three forms of local corticosteroids on preventing SNP recurrence post-operatively.Materials and methods: This double-blind, randomized clinical trial study was conducted on 108 patients with SNP who underwent functional endoscopic sinus surgery (FESS). Permuted Block Randomization randomly assigned patients into three groups of 36 people: budesonide spray, betamethasone drop, and budesonide nebulizing suspension groups. One and six months after surgery, the patients were evaluated for recurrence of SNP by nasal endoscopy. SNOT 22 questionnaire was used to assess patients' subjective improvement rate pre- and post-operatively.Results: According to the scores obtained in the Modified Lund-Kennedy Scoring, budesonide nebulizing suspension showed better effects on preventing the recurrence of sino-nasal polyps after FESS compared with betamethasone nasal drops. The score was significantly lower in the budesonide nebulizing suspension group compared to the betamethasone drop group (P=0.043). There was no statistically significant difference in the scores between the budesonide nebulizing suspension group and the betamethasone spray group (P=0.178). Also, we observed significant improvement in facial fullness in patients who received Budesonide nebulizing suspension.Conclusions: Budesonide nebulizing suspension, compared to betamethasone nasal drops, showed better effects on preventing the recurrence of SNP after FESS.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"36 1","pages":"349-353"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10800139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139520977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Intratympanic Dexamethasone on Bell's palsy: A Clinical Trial. 鼓室内地塞米松治疗贝尔麻痹的临床研究。

Iranian Journal of Otorhinolaryngology Pub Date : 2024-01-01 DOI: 10.22038/ijorl.2024.74635.3510

Ali Bagherihagh, Ardavan Tajdini, Reza Ansari, Behzad Moradi, Mehraveh Sadeghi Ivraghi, Farrokh Heidari

{"title":"Effect of Intratympanic Dexamethasone on Bell's palsy: A Clinical Trial.","authors":"Ali Bagherihagh, Ardavan Tajdini, Reza Ansari, Behzad Moradi, Mehraveh Sadeghi Ivraghi, Farrokh Heidari","doi":"10.22038/ijorl.2024.74635.3510","DOIUrl":"10.22038/ijorl.2024.74635.3510","url":null,"abstract":"Introduction: The main objective of this study is to examine the hypothesis that intratympanic corticosteroids can benefit the treatment of Bell's palsy and shorten the period needed for recovery.Materials and methods: This study was conducted prospectively using double-blind clinical trials. A total of 321 patients with acute unilateral facial paralysis were included in the survey, with 144 patients excluded due to exclusion criteria and 177 patients included. These patients were divided into an intervention group (54 patients) and a control group (123 patients). Prednisolone and acyclovir were given orally to both groups. Intratympanic dexamethasone was given to the intervention group as an additional treatment.Results: Patients' House-Brackmann (H.B.) scores were recorded when they were visited three days, one week, three weeks, three months, and six months after receiving intratympanic dexamethasone. It was discovered that there was no significant difference in H.B. scores between the intervention and control groups. The first day of symptom improvement in the intervention group was 1.81 days after starting treatment, while it took 2.91 days in the control group, which is a significant difference.Conclusion: Intratympanic dexamethasone injection, in addition to the 10-day prednisolone-acyclovir therapy regimen, did not affect patients recovering from Bell's palsy in the short term (three weeks) or long term (six months) but is significantly effective in the first day of recovery as measured by the House-Brackmann scale.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"36 6","pages":"631-637"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epistaxis in Pregnant Women in the Covid-19 Era. 新冠肺炎时代孕妇鼻出血

Iranian Journal of Otorhinolaryngology Pub Date : 2024-01-01 DOI: 10.22038/ijorl.2024.76230.3553

Mustafa Shamkhi Abbood, Eftekhar Shamkhee, Samah Abbas Hammadi

{"title":"Epistaxis in Pregnant Women in the Covid-19 Era.","authors":"Mustafa Shamkhi Abbood, Eftekhar Shamkhee, Samah Abbas Hammadi","doi":"10.22038/ijorl.2024.76230.3553","DOIUrl":"10.22038/ijorl.2024.76230.3553","url":null,"abstract":"Introduction: Epistaxis is common throughout pregnancy and is usually not a cause for concern; severe nosebleeds are rare. An increased rate of nasal bleeding was observed during the COVID-19 epidemic.Materials and methods: The study sample comprised 3,362 pregnant women who sought care at the Gynecologic and Obstetrics Department/ Al-Yarmouk Teaching Hospital and Al-Karkh Maternity Hospital between May 2020 and April 2021. All were asked to fill out a questionnaire.Results: Nine hundred forty-one pregnant women experienced an episode of epistaxis during the last pregnancy. One thousand seven hundred forty-eight pregnant women had a corona-positive history. Pregnant women with a positive history of coronavirus infection have a higher incidence of epistaxis (612 pregnant women) than pregnant women with a corona-negative history (329 pregnant women) P value (0.039%).Conclusions: Oxygen and blood-thinning drugs are the leading causes of the increased rate of nosebleeds among pregnant women during the Corona pandemic.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"36 6","pages":"669-674"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Affecting Factors on Acceptance with CPAP on the First Night of PAP Titration in Sleep Clinic on Patients with Obstructive Sleep Apnea. 确定影响阻塞性睡眠呼吸暂停患者在睡眠门诊中使用 CPAP 的第一晚接受 CPAP 的因素。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-11-01 DOI: 10.22038/IJORL.2023.68296.3325

Reihaneh Heidari, Ayeh Shamsadini, Arezu Najafi, Reza Erfanian

{"title":"Identifying Affecting Factors on Acceptance with CPAP on the First Night of PAP Titration in Sleep Clinic on Patients with Obstructive Sleep Apnea.","authors":"Reihaneh Heidari, Ayeh Shamsadini, Arezu Najafi, Reza Erfanian","doi":"10.22038/IJORL.2023.68296.3325","DOIUrl":"https://doi.org/10.22038/IJORL.2023.68296.3325","url":null,"abstract":"Introduction: This research examined the causes of low acceptance with Continuous Positive Airway Pressure Continuous Positive Airway Pressure (CPAP) especially anatomical causes and if eliminating them would result in increasing its adherence.Materials and methods: This cross sectional study was performed on patients with moderate to severe Obstructive Sleep Apnea Obstructive Sleep Apnea (OSA) undergoing PAP titration in the sleep clinic. CPAP acceptance was evaluated by visual analog scale (VAS) about mask and sleep satisfaction and the possibility of using CPAP in the future, mask complications, physical examination of the upper airway and polysomnographic (PSG) results before and after titration.Results: participants were divided into three groups of non-acceptant, semi-acceptant and acceptant with CPAP based on the satisfaction of the mask and sleep. There were no significant differences between groups based on age, gender, education, BMI and polysomnographic variables. With a study of mask complication, there were significant differences among groups for dry mouth, mask leakage and cold air. (p<0.05) The severity of septal deviation, high arch palate, mallampati, retrognathia and maxillary hypoplasia in the acceptant group was less than the other two groups, but it was not statistically significant.Conclusions: Satisfaction with the sleep and the mask on the first night of titration will significantly increase the likelihood of using CPAP in the future. A number of the pathological physical examinations were lower in the acceptant group than two other groups, but were not significant.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 131","pages":"303-309"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138798062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omega-3 Adjunctive Therapy in Idiopathic SSNHL: A Randomised, Triple-Blind, Placebo-Controlled Trial. 奥米加-3 对特发性 SSNHL 的辅助治疗：一项随机、三联盲、安慰剂对照试验。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-11-01 DOI: 10.22038/IJORL.2023.71955.3444

Benyamin Rahmaty, Kayvan Aghazadeh, Sasan Dabiri, Masoud Motasaddi Zarandy, Ali Kouhi, Nasrin Yazdani, Reza Erfanian, Ardavan Tajdini, Saeed Sohrabpour, Fatemeh Safi, Reza Shamsa, Hamideh Ravand, Neda Jafari

{"title":"Omega-3 Adjunctive Therapy in Idiopathic SSNHL: A Randomised, Triple-Blind, Placebo-Controlled Trial.","authors":"Benyamin Rahmaty, Kayvan Aghazadeh, Sasan Dabiri, Masoud Motasaddi Zarandy, Ali Kouhi, Nasrin Yazdani, Reza Erfanian, Ardavan Tajdini, Saeed Sohrabpour, Fatemeh Safi, Reza Shamsa, Hamideh Ravand, Neda Jafari","doi":"10.22038/IJORL.2023.71955.3444","DOIUrl":"https://doi.org/10.22038/IJORL.2023.71955.3444","url":null,"abstract":"Introduction: Idiopathic Sudden Sensorineural Hearing Loss as a subset of sensorineural hearing loss will be confirmed by a progressive hearing loss of at least 30 dB at three contiguous frequencies over 72 hours or less. A sudden or abrupt hearing loss correlates with the time course, and a vascular event is presumptive aetiology. There is an inverse association between Omega-3 consumption and hearing loss. This study aimed to evaluate the efficacy of Omega-3 adjunctive therapy in Idiopathic Sudden Sensorineural Hearing Loss by audiometric assessments.Materials and methods: In this randomised, triple-blind, placebo-controlled trial, all participants aged 18-70 with a history of sudden deafness (within 12 hours and ≤ 30 days) were eligible for enrollment. They were included if audiology diagnostic tests confirmed the SSNHL. Ultimately, they were randomised to the Omega-3 group and the placebo group.Results: Thirty-three patients were randomly allocated to the Omega-3 group and thirty-two to the placebo group. Vertigo (32.3% of all patients) and underlying conditions had significant relationships with complete response (C.R.)-final hearing level ≤of 25 dB in pure-tone average (P < 0.05). There was no significant difference between both groups before and after treatment. Although it was not statistically significant, patients in the Omega-3 group had faster recovery than placebo.Conclusions: Omega-3 adjunctive therapy did not have a therapeutic effect on SSNHL patients. Moreover, C.R. happened in half the patients. Vertigo and underlying conditions considerably worsen the recovery from SSNHL.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 131","pages":"311-319"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138798174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sinonasal Neuroendocrine Carcinoma in Adult Proteus Syndrome. 成人普罗蒂斯综合征中的鼻窦神经内分泌癌

Iranian Journal of Otorhinolaryngology Pub Date : 2023-11-01 DOI: 10.22038/IJORL.2023.73128.3472

Giorgos Sideris, Thomas Nikolopoulos, Antigone Sourla, Penelope Korkolopoulou, Pavlos Papadakis, Alexander Delides

{"title":"Sinonasal Neuroendocrine Carcinoma in Adult Proteus Syndrome.","authors":"Giorgos Sideris, Thomas Nikolopoulos, Antigone Sourla, Penelope Korkolopoulou, Pavlos Papadakis, Alexander Delides","doi":"10.22038/IJORL.2023.73128.3472","DOIUrl":"https://doi.org/10.22038/IJORL.2023.73128.3472","url":null,"abstract":"Introduction: Proteus syndrome (PS) is a rare genetic disorder usually caused by mutations in AKT1 or PTEN genes, characterized by multiple, asymmetric tissue overgrowth with high clinical variability. Sinonasal neuroendocrine carcinomas (SNEC) are exceptionally rare tumors encountered in the ethmoid sinus, nasal cavity, or maxillary sinus.Case report: We report a 35-year-old patient with PS, who underwent successful surgical removal of a well-differentiated SNEC obstructing his nasal cavity and highlight the role of the otolaryngologist for safe airway management, minimal surgical intervention and coordination of the multidisciplinary care. Histologically, focally hyperplastic mucosal epithelium of respiratory type of the nasal chamber was noticed along with seromucinous glands and capillary congestion of the subepithelial fibrovascular tissue. The limited presence of neoplastic tissue with histomorphological and immunophenotypic features of a neuroendocrine neoplasm was focally observed. Tumor cells grow in the form of islets within a vascular stroma; these neoplastic cells are immunohistochemically positive for synaptophysin, CD56, EMA, Ki67 (low expression, cell proliferation rate: 2%), CD31, chromogranin and pancytokeratin AE1 / AE3 as well as for S-100 protein (weak intensity).Conclusions: This first description of a SNEC in a PS patient, might hint towards a common basis between the two conditions, due to the mosaic AKT1 variant and an activated AKT/PIK3CA/PTEN pathway.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 131","pages":"321-324"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138798268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Immunohistochemical Expression of TRAP in Odontogenic Cysts. 牙源性囊肿中 TRAP 的免疫组化表达比较。

Iranian Journal of Otorhinolaryngology Pub Date : 2023-11-01 DOI: 10.22038/IJORL.2023.63350.3169

Hamideh Kadeh, Shirin Saravani, Ali Jamshidi

{"title":"A Comparative Immunohistochemical Expression of TRAP in Odontogenic Cysts.","authors":"Hamideh Kadeh, Shirin Saravani, Ali Jamshidi","doi":"10.22038/IJORL.2023.63350.3169","DOIUrl":"https://doi.org/10.22038/IJORL.2023.63350.3169","url":null,"abstract":"Introduction: Tartrate-resistant acid phosphatase (TRAP) is an acid phosphatase metalloprotein enzyme expressed in osteoclasts and is related to bone resorption. The molecular mechanisms involved in the different behavior of odontogenic keratocysts have not yet been fully elucidated. The purpose of this study was to compare TRAP expression in odontogenic keratocysts, radicular cysts, and dentigerous cysts.Materials and methods: In this cross-sectional study, we selected 60 samples, including 20 cases of each one of the odontogenic keratocysts (OKC), radicular cysts (RC) and dentigerous cysts (DC). The samples were stained with TRAP monoclonal antibodies using immunohistochemistry. The data were analyzed using the Chi-Square and Kruskal-Wallis tests.Results: In this study, TRAP expression was observed in the lining epithelium of 50% of OKC cases and 5% of RC cases, while it was negative in the lining epithelium of DC. This difference was statistically significant (p<0.001). Moreover, the TRAP staining intensity in the lining epithelium had a significant difference between the groups (P<0.001). TRAP expression in the connective tissue of OKC, RC, and DC was positive in 35%, 30%, and 20% of the cases, respectively. This difference was not statistically significant (P=0.788). Also, staining intensity of TRAP-positive cells in the connective tissue of the lesions was not significant (P=0.634).Conclusion: In this study, we found a higher expression of TRAP in the lining epithelium of OKC, which may be one of the reasons for the aggressive behavior of OKC compared to other cysts. This finding supports the classification of OKC as an odontogenic tumor.","PeriodicalId":14607,"journal":{"name":"Iranian Journal of Otorhinolaryngology","volume":"35 131","pages":"295-301"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0