Chemistry - An Asian Journal最新文献_第8页

Supramolecular Pathway Complexity of a Host-Guest System Revealed in the Single-Crystal Structural Snapshots 单晶结构快照揭示主客体系统的超分子通路复杂性

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-16 DOI: 10.1002/asia.70945

Kateryna Kravets, Mykola Kravets, Oksana Danylyuk

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Variation of Arene Moiety in Ruthenium (II) Arene Halido Complexes of Quinoline and Benzazole-Derived Ligands: Development and Antiprostate Cancer Potential 喹啉和苯唑类配体的钌（II）芳烃卤代配合物中芳烃部分的变化：发展和抗前列腺癌的潜力

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-16 DOI: 10.1002/asia.70946

Tanveer A. Khan, Anubha Yadav, Priyal Malpani, Kishalay Bhar, Vinit Kumar, Anuj K. Sharma

{"title":"Variation of Arene Moiety in Ruthenium (II) Arene Halido Complexes of Quinoline and Benzazole-Derived Ligands: Development and Antiprostate Cancer Potential","authors":"Tanveer A. Khan, Anubha Yadav, Priyal Malpani, Kishalay Bhar, Vinit Kumar, Anuj K. Sharma","doi":"10.1002/asia.70946","DOIUrl":"https://doi.org/10.1002/asia.70946","url":null,"abstract":"<div>\u0000 \u0000 Castration-resistant prostate cancer (CRPC) is an advanced, treatment-refractory disease with high mortality and limited therapeutic options, necessitating novel metallodrugs with enhanced potency and reduced toxicity. Herein, we report the design and syntheses of two quinoline–benzazole hybrid bidentate ligands—2-(1H-benzo[d]imidazol-2-yl)quinoline (L1) and 2-(quinolin-2-yl)benzo[d]thiazol (L2)—along with four new half-sandwich ruthenium(II) arene chlorido complexes of the general formula [(η6-arene)(L)RuCl]PF6, where arene = benzene (Bz) or hexamethylbenzene (Hmb), yielding complexes 1–4. The ligands and complexes were fully characterized by spectroscopic (1H/13C NMR, IR, UV–vis) and analytical methods (elemental analysis, ESI-MS), with aqueous stability profiles confirming their suitability for biological evaluation. Cytotoxicity assays against the PC-3 CRPC cell line identified potent antiproliferative activity in selected complexes. Mechanistic studies revealed predominant G2/M phase cell cycle arrest, induction of apoptosis, and moderate-to-strong DNA binding affinities suggestive of intercalative/groove-binding modes. These results highlight the potential of quinoline–benzazole Ru(II) arene scaffolds as promising candidates for CRPC therapy, meriting further optimization.\u0000 </div>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"21 16","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Improved Synthesis of Sodium and Potassium Salts of Tetrakis (Pentafluorophenyl)Borates 四（五氟苯）硼酸盐钠、钾盐的改进合成

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-16 DOI: 10.1002/asia.70952

Emily A. Murray-Nobbs, Jarrod R. Thomas, Cameron M. Gould, John M. Cusick, Scott A. Sulway

引用次数: 0

Mitochondria-Targeted Cancer Therapy Using an Endogenous Stimuli-Responsive Prodrug With Aggregation-Induced-Emission Features 利用具有聚集诱导发射特性的内源性刺激反应前药进行线粒体靶向癌症治疗

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-15 DOI: 10.1002/asia.70885

Priyanka Patra, Sreejesh Sreedharan, Anitha Ethirajan, Sumit Kumar Pramanik

{"title":"Mitochondria-Targeted Cancer Therapy Using an Endogenous Stimuli-Responsive Prodrug With Aggregation-Induced-Emission Features","authors":"Priyanka Patra, Sreejesh Sreedharan, Anitha Ethirajan, Sumit Kumar Pramanik","doi":"10.1002/asia.70885","DOIUrl":"https://doi.org/10.1002/asia.70885","url":null,"abstract":"<div>\u0000 \u0000 Theranostic agents derived from aggregation-induced emission luminogens (AIEgens) offer significant potential, yet platforms that provide controlled drug release, organelle-specific action, and self-reporting capability are highly desired. Herein, we report a mitochondria-targeted prodrug system that integrates an AIE fluorophore with excited-state intramolecular proton transfer (ESIPT) characteristics, covalently linked to the anticancer drug dasatinib. The amphiphilic prodrug self-assembled into nanoparticles of around 210 nm with a spherical morphology. The probe is initially non-fluorescent due to ESIPT inhibition. Following cellular internalization, intracellular esterases cleave the carbonate linker, initiating two simultaneous processes: (1) the cytosolic release of dasatinib to inhibit proliferation-associated tyrosine kinases, and (2) the restoration of ESIPT and subsequent aggregation of the fluorophore, yielding a ratiometric fluorescence turn-on signal for real-time monitoring. The liberated probe, appended with a triphenylphosphine moiety, then selectively targets mitochondria, where it generates reactive oxygen species (ROS), inducing mitochondrial damage and promoting apoptosis. This combination of cytosolic kinase inhibition and mitochondria-targeted ROS production creates a powerful synergistic anticancer effect, demonstrating significantly enhanced efficacy over dasatinib alone. This multifunctional design pioneers a theranostic approach that merges precise drug activation, dynamic imaging, and organelle-specific therapy.\u0000 </div>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"21 16","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synergistic Effect of Co-VN-Supported Nitrogen-Doped Porous Carbon to Enhance the Catalytic Activity and Stability of Cathode in Lithium–Sulfur Batteries co - vn负载的氮掺杂多孔碳对提高锂硫电池正极催化活性和稳定性的协同作用

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-05 DOI: 10.1002/asia.70911

Xuefeng Zhang, Qian Lv, Shan Ji, Hui Liu, Zaiyong Mo, Chaoyang Sun, Vladimir Linkov, Hui Wang

{"title":"Synergistic Effect of Co-VN-Supported Nitrogen-Doped Porous Carbon to Enhance the Catalytic Activity and Stability of Cathode in Lithium–Sulfur Batteries","authors":"Xuefeng Zhang, Qian Lv, Shan Ji, Hui Liu, Zaiyong Mo, Chaoyang Sun, Vladimir Linkov, Hui Wang","doi":"10.1002/asia.70911","DOIUrl":"10.1002/asia.70911","url":null,"abstract":"<div>\u0000 \u0000 Transition metal-supported nitrogen-doped carbon materials possess the advantages of high catalytic activity and large specific surface area; therefore, they are considered to be the most promising cathode catalysts for lithium–sulfur batteries. However, their practical application has been impeded by poor rate performance and cycling stability due to sluggish reaction kinetics and the polysulfide shuttling effect. Herein, bimetallic cobalt and vanadium nitride supported on porous nitrogen-doped carbon materials (Co-VN/NC) were prepared in a molten salt medium at high temperatures. The as-prepared Co-VN/NC exhibits a large specific surface area, which provides ample space for loading the metal-based compounds. Furthermore, the bimetallic compounds supported on porous N-doped carbon provide abundant active sites on the surface, which enhance the sulfur-fixing ability while accelerating the conversion of polysulfides. The discharge specific capacity of the Co-VN/NC-based Li-S battery is as high as 1170 mAh g−1 at 0.2 C, and it retains 821 mAh g−1 at 1 C. During cycling stability tests, the average decay rate per cycle is only 0.046% over 400 continuous cycles at 1 C. These electrochemical results demonstrate that the Co-VN/NC is a promising cathode material for practical application in Li–S batteries.\u0000 </div>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"21 15","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synthesis and Studies of BODIPY-Ferrocene Conjugates: An Overview bodipy -二茂铁缀合物的合成与研究综述。

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-05 DOI: 10.1002/asia.70919

Mushtaque A. S. Shaikh, Priti Khedkar, Shilpi Misra, Tamanna K. Khan

{"title":"Synthesis and Studies of BODIPY-Ferrocene Conjugates: An Overview","authors":"Mushtaque A. S. Shaikh, Priti Khedkar, Shilpi Misra, Tamanna K. Khan","doi":"10.1002/asia.70919","DOIUrl":"10.1002/asia.70919","url":null,"abstract":"<div>\u0000 \u0000 Boron(III) difluoro dipyrromethene (BODIPY) dyes are known for their strong absorption, high fluorescence quantum yields, narrow emission bands, and high photostability. These properties make them suitable for sensing, imaging, and therapeutic applications. The incorporation of the redox-active ferrocene unit into the BODIPY framework yields donor–acceptor hybrid systems with fascinating electronic and photophysical properties. In these systems, photoinduced electron transfer often triggers fluorescence quenching and facilitates reversible electrochemical control of excited states. Structural modification of the BODIPY core, particularly through the incorporation of π-conjugated linkers (e.g., C═C and C≡C bonds) at the meso- and pyrrolic positions, extends the conjugation. These modifications enhance electronic communication between donor ferrocene and acceptor BODIPY and allow the incorporation of auxiliary units like porphyrin, pyrene, fullerene, and biotin. This review highlights recent advances in the synthesis of BODIPY-ferrocene conjugates using Sonogashira coupling, Knoevenagel condensation, and click chemistry. Their spectroscopic, electrochemical, and computational investigations are also described, including their tunable photophysical, redox properties, and prospective applications in sensors, molecular switches, and optoelectronic materials.\u0000 </div>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"21 15","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occurrence of Isomorphism and Quasi-Isostructurality in the Crystal Chemistry of Halogen-Substituted Phenylbenzimidamides 卤素取代苯基苯并咪胺晶体化学中同形性和准同构性的发生。

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-05 DOI: 10.1002/asia.70927

Shubham Som, Peuli Ghosh, Manasmita Panda, Deepak Chopra

{"title":"Occurrence of Isomorphism and Quasi-Isostructurality in the Crystal Chemistry of Halogen-Substituted Phenylbenzimidamides","authors":"Shubham Som, Peuli Ghosh, Manasmita Panda, Deepak Chopra","doi":"10.1002/asia.70927","DOIUrl":"10.1002/asia.70927","url":null,"abstract":"<div>\u0000 \u0000 The phenomenon of polymorphism and isostructurality, though conceptually distinct, is governed by the role of intermolecular interactions that are of importance in crystal packing. Here, we report the synthesis and structural characterization of mono- and di-substituted chloro/bromo phenyl benzimidamides to explore these phenomena. Extensive screening of the compounds resulted in (Z)-N'-(4-bromophenyl)benzimidamide existing as dimorphs, which, despite differences in crystal density and thermal stability, exhibit nearly isostructural packing, as confirmed by structure similarity analysis. Interaction energy calculations confirmed their isoenergetic nature and established them as being ‘quasi-isostructural polymorphs’, an intermediate state between polymorphism and isostructurality. Other halogen-substituted derivatives displayed similar unit cell parameters, and their structural similarity analysis confirmed the same. Three-dimensional isostructurality with a low dissimilarity index value, yielding isomorphous chloro/bromo pairs. The crystal packing analysis and intermolecular interaction energy calculations further revealed comparable interaction topologies and energetic contributions across these isostructural pairs. Quantitative investigation demonstrated consistent intermolecular interaction motifs, dominated by strong N…H hydrogen bonds, together with Cl/Br…H interactions. Together, these results provide deep insights into how subtle changes in the position of the same or different functional groups govern crystal packing and energetics in halogen-substituted molecules.\u0000 </div>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"21 15","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Selective Synthesis and Photothermal Conversion Properties of U- and S-Shaped Flexible Double-Metallacycle Assemblies U形和s形柔性双金属循环组件的选择性合成及其光热转换性能。

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-05 DOI: 10.1002/asia.70917

Yao He, Ming-Yu Lu, Jian-Xin Yang, Ying Zhao, Li-Long Dang, Yu-Ming Guo, Lu-Fang Ma

{"title":"The Selective Synthesis and Photothermal Conversion Properties of U- and S-Shaped Flexible Double-Metallacycle Assemblies","authors":"Yao He, Ming-Yu Lu, Jian-Xin Yang, Ying Zhao, Li-Long Dang, Yu-Ming Guo, Lu-Fang Ma","doi":"10.1002/asia.70917","DOIUrl":"10.1002/asia.70917","url":null,"abstract":"<div>\u0000 \u0000 Molecular double-metallacycles have drawn considerable interest for their unique architectures and broad application prospects, yet selective synthesis remains a significant challenge. This work reports a novel triimidazolyl flexible ligand precursor L1 containing a phenyl unit with three methyl groups and three methylene spacers that enable flexibility for the coordination of imidazole units. Together with three half-sandwich rhodium building blocks (B1–B3) of varying conjugation sizes, L1 was assembled via coordination-driven self-assembly and silver-ion bridging to afford one U-shaped and two S-shaped double-metallacycles in high yields. The greater steric demand of B2 and B3 favored the S-shaped topology. The formation of all target structures was clearly confirmed by SC-XRD (Single-crystal x-ray diffraction analysis), NMR (Nuclear magnetic resonance) spectroscopy, IR (Infrared) spectroscopy, and ESI-TOF-MS (Electrospray Ionization-Time of Flight Mass) spectrometry. TGA (Thermogravimetric analysis) indicated good thermal stability for compounds 1–3. Photothermal conversion experiments revealed that S-shaped double-metallacycle 3 achieves notable photothermal conversion efficiency (21.46%–22.95%) in the NlR (near-infrared) region. EPR (Electron paramagnetic resonance) studies further corroborated that radical generation from the building blocks enhances photothermal performance.\u0000 </div>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"21 15","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical Study on Passive Behavior of Hastelloy C-276 in Ammonium Chloride Solution With Sodium Thiosulphate 哈氏合金C-276在含硫代硫酸钠氯化铵溶液中钝化行为的电化学研究。

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-05 DOI: 10.1002/asia.70916

Shakir Hussain Koondhar, Muhammad Ali Siddiqui, H. M. Ahsen Ilyas, Di Taishen, Liu Huaizhu, Chen Liangchao, Jinping Xiong

{"title":"Electrochemical Study on Passive Behavior of Hastelloy C-276 in Ammonium Chloride Solution With Sodium Thiosulphate","authors":"Shakir Hussain Koondhar, Muhammad Ali Siddiqui, H. M. Ahsen Ilyas, Di Taishen, Liu Huaizhu, Chen Liangchao, Jinping Xiong","doi":"10.1002/asia.70916","DOIUrl":"10.1002/asia.70916","url":null,"abstract":"<div>\u0000 \u0000 The corrosion behavior of C-276 alloy in 5 M ammonium chloride solution containing different concentrations of sodium thiosulfate (0–0.4 M) was investigated using Potentiodynamic polarization, cyclic voltammetry, electrochemical impedance spectroscopy and Mott-Schottky analysis. Sodium thiosulphate increasing shows the increasing corrosion current density icorr and passive current density, pitting potential also shift to lower values shows degradation of passive film. Cv analysis revealed anodic peak shifts to lower potentials with increasing thiosulfate concentration, suggested easier passive film transformation. EIS results showed a decrease in charge transfer resistance and an increase in capacitance, showed reduced film stability and increased surface heterogeneity. Mott-Schottky analysis demonstrated both n-type and p-type semiconductor behavior, with increasing donor and acceptor densities confirmed higher defect concentration in the passive film.\u0000 The passive film is interpreted as a multi-component oxide/hydroxide layer consisting of a Cr rich inner barrier layer and an outer hydroxide layer containing Mo and Ni. The corrosion mechanism is explained using the Point Defect Model (PDM), where defect generation, migration, and accumulation lead to passive film breakdown and localized corrosion. The synergistic effect of chloride and thiosulfate ions accelerates passive film degradation and enhances corrosion susceptibility of the alloy.\u0000 </div>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"21 15","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen-Bond DonorAssisted Cycloaddition of CO2 to Epoxides Catalyzed by Schiff Base Derived Ionic Liquids: Catalytic, Mechanistic, and Kinetic Studies 由希夫碱衍生离子液体催化的氢键供体辅助CO2环加成环氧化物：催化、机理和动力学研究。

IF 3.2 3区化学

Chemistry - An Asian Journal Pub Date : 2026-08-05 DOI: 10.1002/asia.70915

Saurav Paul, Surabhi Lahkar, Sanfaori Brahma

{"title":"Hydrogen-Bond DonorAssisted Cycloaddition of CO2 to Epoxides Catalyzed by Schiff Base Derived Ionic Liquids: Catalytic, Mechanistic, and Kinetic Studies","authors":"Saurav Paul, Surabhi Lahkar, Sanfaori Brahma","doi":"10.1002/asia.70915","DOIUrl":"10.1002/asia.70915","url":null,"abstract":"<div>\u0000 \u0000 Four new salicylaldehyde, o-vanillin, 5-nitrosalicylaldehyde and benzaldehyde derived Schiff base ionic liquids (ILs) with bromide counterion (IL-Sal, IL-Van, IL-NSal, and IL-Bz) have been facilely synthesized. The co-existing phenolic-OH and counteranion, Br− in IL-Sal, IL-Van, and IL-NSal are employed as bifunctional organocatalysts for epoxide-CO2 coupling reaction, where -OH activates the epoxide via hydrogen bonding and Br− promotes ring opening. Experimental evidence from controlled experiments, FT-IR and NMR spectroscopy corroborates a catalytic mechanism involving catalyst-epoxide hydrogen bonding. A control experiment using IL-Bz, lacking phenolic-OH, shows inferior activity compared to IL-Sal [cf. substrate: butyl glycidyl ether; conversion: 9% (cat. IL-Bz); 90% (cat. IL-Sal)], confirming the crucial role of -OH as HBD in epoxide activation. Further, NMR spectroscopic investigation reveals H-bonding via downfield shifts with slightly reduced intensity, supported by FT-IR through shifting of the O-H stretching band. Kinetic studies indicate first-order kinetics with rate constants of 1.2 × 10−5 s−1, 2.2 × 10−5 s−1 and 2.7 × 10−5 s−1 at 40°C, 60°C, and 80°C, respectively. Activation parameters are ΔH# = 7.50 ± 0.40 kJ·mol−1 and ΔS# = −244.5 ± 1.21 J·mol−1·K−1. The catalyst also shows good recyclability with conversions of 94%, 89%, and 85% in three consecutive cycles.\u0000 </div>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"21 15","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0