Chemistry - An Asian Journal最新文献

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Supported Nickel Nanoparticles as Catalyst in Direct sp3 C-H Alkylation of 9H-Fluorene Using Alcohols as Alkylating Agent. 以醇为烷化剂,将支撑镍纳米颗粒作为 9H-Fluorene 直接 sp3 C-H 烷基化反应的催化剂。
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2025-01-02 Epub Date: 2024-11-12 DOI: 10.1002/asia.202400989
Vageesh M, Harsh Joshi, Anupriya A S, Raju Dey
{"title":"Supported Nickel Nanoparticles as Catalyst in Direct sp<sup>3</sup> C-H Alkylation of 9H-Fluorene Using Alcohols as Alkylating Agent.","authors":"Vageesh M, Harsh Joshi, Anupriya A S, Raju Dey","doi":"10.1002/asia.202400989","DOIUrl":"10.1002/asia.202400989","url":null,"abstract":"<p><p>Herein, we report an inexpensive first-row transition metal Ni heterogeneous catalytic system for the C<sub>sp</sub> <sup>3</sup>-mono alkylation of fluorene using alcohols as alkylating agents via borrowing hydrogen strategy. The catalytic protocol displayed versatility with high yields of the desired products using various types of primary alcohols, including aryl/hetero aryl methanols, and aliphatic alcohols as alkylating agents. The catalyst Ni NPs@N-C was synthesized via high-temperature pyrolysis strategy, using ZIF-8 as the sacrificial template. The Ni NPs@N-C catalyst was characterized by XPS, HR-TEM, HAADF-STEM, XRD and ICP-MS. The catalyst is stable even in the air at room temperature, displayed excellent activity and could be recycled 5 times without appreciable loss of its activity.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202400989"},"PeriodicalIF":3.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Spacers as a Probe in Variation of Photoluminescence Properties of Mono- and Bi-Nuclear Boron Compounds. 作为单核和双核硼化合物光致发光特性变化探针的间隔物的作用。
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2025-01-02 Epub Date: 2024-11-16 DOI: 10.1002/asia.202401113
Rahul Kumar Yadav, Darakshan Parveen, Bijan Mondal, Dipak Kumar Roy
{"title":"The Role of Spacers as a Probe in Variation of Photoluminescence Properties of Mono- and Bi-Nuclear Boron Compounds.","authors":"Rahul Kumar Yadav, Darakshan Parveen, Bijan Mondal, Dipak Kumar Roy","doi":"10.1002/asia.202401113","DOIUrl":"10.1002/asia.202401113","url":null,"abstract":"<p><p>A series of N,O donor-based mono- and binuclear four-coordinated boron complexes were synthesized. Depending on the substitution and spacer, these complexes exhibit intense blue, green and yellow emission in solution states. Notably, the fluorescence quantum yields (Φ<sub>F</sub>) and fluorescence decay (lifetime, τ) of mononuclear boron complexes (2 a-2 e) were higher than the binuclear boron complexes (2 f-2 k). The lowest lifetime and quantum yield in binuclear boron complexes were due to intramolecular rotation induced non radiative processes. The disulphide spacer-based boron complexes 2 i-2 k showed aggregation-caused quenching in the THF/H<sub>2</sub>O mixture whereas no other complexes were ACQ responsive. These complexes show large Stokes shift, one of them i. e. 2 e has the highest Stokes shift of 130 nm. Further, the electrochemical study suggests the presence of two redox incidences. Theoretical studies show close corroboration between the TD-DFT computed and experimentally measured absorption maxima as well as DFT (GIAO) calculated and experimentally measured <sup>11</sup>B NMR values. This complements the appropriate selection of the theoretical methods to shed light on the electronic transitions in the mono- and binuclear BF<sub>2</sub> complexes.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401113"},"PeriodicalIF":3.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in enzyme-activated dual-locked probes for biological applications.
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2025-01-01 DOI: 10.1002/asia.202401647
Yanhua Li, Gangwei Jiang, Junliang Zhou, Ling Shi, Lin Yuan
{"title":"Recent advances in enzyme-activated dual-locked probes for biological applications.","authors":"Yanhua Li, Gangwei Jiang, Junliang Zhou, Ling Shi, Lin Yuan","doi":"10.1002/asia.202401647","DOIUrl":"https://doi.org/10.1002/asia.202401647","url":null,"abstract":"<p><p>Enzymes catalyze reactions involved in diverse physiological, pathological, and pharmacological processes. By employing the optical probe, fluorescence imaging enables non-invasive, real-time detection and assessment of disease states based on enzymatic activity. However, most enzyme-activated probes are single-locked probes that respond to a single biomarker. In comparison to single-locked probes, enzyme-activated dual-locked probes can effectively minimize the occurrence of false-positive signals, circumvent the problem of low specificity associated with biologically active substances, and facilitate precise imaging. This review systematically summarizes the design and application of dual-locked probes in disease diagnosis, with the aim of providing inspiration for researchers in the field.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401647"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Alkali Metal Ions in Cooperative Electrocatalysis by Bifunctional Co-Mn-Mixed Phosphates.
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2024-12-31 DOI: 10.1002/asia.202401177
Ramaswamy Murugavel, Savi Chaudhary
{"title":"The Role of Alkali Metal Ions in Cooperative Electrocatalysis by Bifunctional Co-Mn-Mixed Phosphates.","authors":"Ramaswamy Murugavel, Savi Chaudhary","doi":"10.1002/asia.202401177","DOIUrl":"https://doi.org/10.1002/asia.202401177","url":null,"abstract":"<p><p>Developing cost-effective, non-precious metal bifunctional electrocatalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is crucial for advancing sustainable energy storage and conversion technologies, including zinc-air batteries, fuel cells, and water electrolyzers. This study presents a one-pot synthesis of cobalt-manganese mixed phosphates as effective bifunctional electrocatalysts for both ORR and OER. Among the catalysts tested, Na-Co-Mn-P [NaCo1.5Mn1.5(HPO4)2(PO4)] exhibited the highest catalytic activity, with a minimal ΔE of 0.86 V, indicating superior performance. The incorporation of alkali metals and the synergistic effects of metal and phosphate components enhance conductivity, electrochemical surface area, and mixed valency of transition metals, contributing to improved electrocatalytic activity. This work highlights a straightforward synthesis method and the beneficial role of metal-phosphate synergy in oxygen electrocatalysis.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401177"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Luminescent Co-assemblies of Donor-Acceptor Dimeric Cyanostilbenes with (Bio)Anionic Polymeric Templates.
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2024-12-31 DOI: 10.1002/asia.202401163
Supratim Banerjee, Susmit Som, Sharanabasava D Hiremath, Richeek Sarkar
{"title":"Luminescent Co-assemblies of Donor-Acceptor Dimeric Cyanostilbenes with (Bio)Anionic Polymeric Templates.","authors":"Supratim Banerjee, Susmit Som, Sharanabasava D Hiremath, Richeek Sarkar","doi":"10.1002/asia.202401163","DOIUrl":"https://doi.org/10.1002/asia.202401163","url":null,"abstract":"<p><p>Amphiphilic dimeric cyanostilbenes with two donor-acceptor moieties connected through variable aliphatic linkers displayed aggregation in aqueous media to produce red emissive nano-assemblies. In the presence of anionic biopolymers such as ctDNA and heparin, they formed electrostatically driven co-assemblies with enhanced luminescence. Moreover, due to the chiral nature of the bio-templates DNA and heparin, the co-assemblies demonstrated induced chirality features. Although the central double bond in cyanostilbenes is known to undergo various photochemical conversions, these dimeric donor-acceptor cyanostilbenes, in their self-assembled state, essentially remained photoinactive under UV irradiation. However, in the bio-templated co-assemblies, they showed comparatively higher photo-reactivity, which was especially prominent for the ctDNA based co-assemblies. We also found that these co-assemblies can be used as artificial light-harvesting systems by incorporating acceptor dyes and this led to the generation of amplified emission from the acceptor dyes in the NIR range of the spectrum. Furthermore, the co-assemblies demonstrated selective fluorescence quenching in the presence of metal ions such as Cu²⁺ and Fe²⁺, highlighting their potential for metal-ion sensing applications.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401163"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ni(II)-Directed Supramolecular Metallogel: Stimuli Responsiveness and Semiconducting Device Fabrication.
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2024-12-30 DOI: 10.1002/asia.202401429
Surajit Singh, Shant Chhetri, Debasish Haldar
{"title":"Ni(II)-Directed Supramolecular Metallogel: Stimuli Responsiveness and Semiconducting Device Fabrication.","authors":"Surajit Singh, Shant Chhetri, Debasish Haldar","doi":"10.1002/asia.202401429","DOIUrl":"https://doi.org/10.1002/asia.202401429","url":null,"abstract":"<p><p>Metal-organic gels (MOGs) are a type of supramolecular complex that have become highly intriguing due to their synergistic combination of inorganic and organic elements. We report the synthesis and characterization of a Ni-directed supramolecular gel using chiral amino acid L-DOPA (3,4-dihydroxy phenylalanine) containing ligand, which coordinates with Ni(II) to form metal-organic gels with exceptional properties. The functional Ni(II)-gel was synthesized by heating nickel(II) acetate hexahydrate and the L-DOPA containing ligand in DMSO at 70 °C. The rheological tests have verified the gel with its mechanical stability, while a SEM image has shown a spherical aggregate morphology. The gel is photo-responsive in nature and exhibits gel to sol transformation upon adsorption of toxic gases like NH<sub>3</sub> or H<sub>2</sub>S. Notably, electrical conductivity of the gel was observed in electronic metal-semiconductor (MS) junctions' devices with a measured conductivity of 0.9×10<sup>-6</sup> Sm<sup>-1</sup>. These devices also exhibited Schottky barrier diode characteristics, underscoring the multifunctional potential of the Ni(II)-gel.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401429"},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Mitochondria-Targeted Iridium(iii) Phosphorescent Probe for Selective Detection of Hypochlorite in Living Cells.
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2024-12-30 DOI: 10.1002/asia.202401351
Wenjuan Xu, Haoxuan Wang, Ying Guang, Zhiqiang Pan, Kai Chen, Tingchun Ma, Jing Zhang
{"title":"A Mitochondria-Targeted Iridium(iii) Phosphorescent Probe for Selective Detection of Hypochlorite in Living Cells.","authors":"Wenjuan Xu, Haoxuan Wang, Ying Guang, Zhiqiang Pan, Kai Chen, Tingchun Ma, Jing Zhang","doi":"10.1002/asia.202401351","DOIUrl":"https://doi.org/10.1002/asia.202401351","url":null,"abstract":"<p><p>Hypochlorous acid(HClO)/hypochlorite ion (ClO-) is a highly reactive oxygen species (ROS) that play a crucial role in various biological processes. In this paper, a \"turn-on\" phosphorescent probe (Ir-TPP) for detecting ClO- in mitochondria was designed and synthesized. In solution, Ir-TPP is minimal emission due to rapid isomerization of C=N-OH as an efficient non-radiative decay process. When Ir-TPP was reacted with ClO- to form an oxidized carboxylate product, there is a significant enhancement both in absorbance and emission intensity, resulting in approximately 19-fold increase in phosphorescence signal. Furthermore, the probe demonstrates high selectivity towards other anions and ROS. It also exhibits specific targeting ability towards mitochondria with a co-staining coefficient of 94% compared to commercial dyes, enabling \"turn-on\" detection of ClO- within mitochondria.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401351"},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metal-mediated Protein Engineering within live Cells.
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2024-12-30 DOI: 10.1002/asia.202401669
Pritam Ghosh
{"title":"Metal-mediated Protein Engineering within live Cells.","authors":"Pritam Ghosh","doi":"10.1002/asia.202401669","DOIUrl":"https://doi.org/10.1002/asia.202401669","url":null,"abstract":"<p><p>Metal mediated several organic reactions are known which can be used inside the cellular medium for protein modifications, eventually for targeting diseases. Indeed, due to ease of handling-rapid solubility-fast cell penetration metals are superior than any other competitor as a stimulus/mediator in organic reactions relevant with protein modifications. Metal mediated most effective reactions as a chemical biology tool are Cu(I)-catalyzed azide-alkyne cycloaddition(CuAAC)/click reactions or Pd mediated multiple chemical reactions for intra/extra cellular protein modifications etc. A few examples of Au(III), Ru(III) are also known. Among these, the click reaction has high potential for the management of biomolecules within cells, and thus this methodology is adopted broadly in chemistry, biology towards therapeutic applications in pharmacology. Fast kinetics in aqueous medium at ambient to normal temperature with specificity between precursors (e.g., azide and alkyne for click reactions which are bio-orthogonal to cells) are essential aspects behind the success of metal mediated intracellular reactions. This review dealt with specifically metal mediated protein modifications within live cells, the achievements and challenges.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401669"},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C(sp3)-H Bond Functionalization of 8-Methylquinolines.
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2024-12-30 DOI: 10.1002/asia.202401266
Diksha Parmar, Rohit Kumar, Upendra Sharma
{"title":"C(sp3)-H Bond Functionalization of 8-Methylquinolines.","authors":"Diksha Parmar, Rohit Kumar, Upendra Sharma","doi":"10.1002/asia.202401266","DOIUrl":"https://doi.org/10.1002/asia.202401266","url":null,"abstract":"<p><p>Quinolines have emerged as essential components in various medicinal agents, playing a key role in treating various ailments. Numerous drugs with a quinoline core have been recognized for their antimalarial, antibacterial, and anticancer activities and have been successfully commercialized, including chloroquine, ciprofloxacin, topotecan, etc. Over the past two decades, we have witnessed a tremendous expansion in the C-H bond functionalization of quinoline scaffolds to widen this chemical space for drug discovery further. This review article summarizes the efforts toward C(sp3)-H functionalization of 8-methylquinolines for C(sp3)-C/X bond formation under metal and metal-free strategies. Each section briefly overviews the C(sp3)-H functionalization of 8-methylquinoline, highlighting the metal and metal-free approaches.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401266"},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic Assisted DNA Logic Gate Nanomachine Based on CRISPR/Cas12a for Recognition of Dual miRNAs.
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2024-12-30 DOI: 10.1002/asia.202401209
Huiping Liang, Xiaomei Mu, Yong Huang, Shulin Zhao, Jianniao Tian
{"title":"Magnetic Assisted DNA Logic Gate Nanomachine Based on CRISPR/Cas12a for Recognition of Dual miRNAs.","authors":"Huiping Liang, Xiaomei Mu, Yong Huang, Shulin Zhao, Jianniao Tian","doi":"10.1002/asia.202401209","DOIUrl":"https://doi.org/10.1002/asia.202401209","url":null,"abstract":"<p><p>The anomalous expression of microRNA poses a serious threat to human life and health safety, and serves as an important biomarker for cancer detection. In this study, a novel magnetic-assisted DNA logic gate nanomachine triggered by miRNA-21 and miRNA-155 was designed based on the trans-cleavage activity of CRISPR/Cas12a activated by a split DNA activator, using only a single crRNA and signal probe, which simplified the detection procedure and complex nucleic acid amplification. The presence of target molecules, miRNA-21 and miRNA-155, can stimulate the DNA walker machine assembled on magnetic beads, which releases activator under the action of DNAzyme. Then the trans-cleavage activity of CRISPR/Cas12a is initiated and the system signal significantly increases. Based on this, an AND logic gate nanomachine was constructed for simultaneous analysis of miRNA-21 and miRNA-155. The detection limits of miRNA-21 and miRNA-15 were 9.00 pM and 42.00 pM, respectively, and this method was successfully applied to miRNA analysis in cell samples. This nanomachine combined the DNA walker with DNA logic circuit and CRISPR/Cas12a system, providing a new approach for simultaneous detection of multiple targets and further expanding the application of gene editing in the analysis and sensing of multiple target substances.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401209"},"PeriodicalIF":3.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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