Turn-On Luminescent Detection of Liver Cancer Biomarker β-Glucuronidase Using a Terbium-Based Paper Sensor.

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2025-06-10 DOI:10.1002/asia.202401975

Shruthi Sakthivel, Ananya Biswas, Uday Maitra

引用次数: 0

Abstract

We report the first turn-on lanthanide luminescent probe for time-gated detection of liver cancer biomarker β-glucuronidase. This innovative assay offers unprecedented rapidity, simplicity, and sensitivity, requiring minimal sample volumes and boasting exceptionally low detection limits (LOD of 40 ng/mL). The protocol was simplified and made "instrument-free" by developing TbCh gel-immobilized paper sensors and measuring the luminescence response after enzyme addition using ImageJ software.

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基于铽基纸传感器的肝癌生物标志物β-葡萄糖醛酸酶的发光检测

我们报道了首个用于肝癌生物标志物β-葡萄糖醛酸酶时间门控检测的镧系发光探针。这种创新的检测方法提供了前所未有的快速、简单和灵敏度，需要最少的样本量，并且具有极低的检测限（LOD为40 ng/mL）。通过开发TbCh凝胶固定化纸传感器，并使用ImageJ软件测量加酶后的发光响应，简化了方案，实现了“无仪器”。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).