Chemistry - An Asian Journal最新文献_第9页

Front Cover: All-Carbon Quaternary Center Containing Tetrahydro-5H-benzo[c]fluorenes via Highly Stereoselective Transannular Carbocation Cyclization (Chem. Asian J. 11/2025) 封面：通过高立体选择性跨环碳正离子环化，含四氢- 5h -苯并[c]芴的全碳季中心亚洲J. 11/2025)

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-21 DOI: 10.1002/asia.202581101

Kasam Poonswat, Sineenart Attanonchai, Paratchata Batsomboon, Chatphorn Theppitak, Kittipong Chainok, Somsak Ruchirawat, Poonsakdi Ploypradith

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Cover Feature: Exploring the Potential of Metal–Organic Frameworks as Reverse Osmosis Membranes for Water Desalination (Chem. Asian J. 11/2025) 封面专题：探讨金属-有机框架作为水淡化反渗透膜的潜力（化学）。亚洲J. 11/2025)

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-21 DOI: 10.1002/asia.202581102

Qiang Lyu, Li-Chiang Lin

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Molecular Insights into Osmolyte-Mediated Adaptation of Lipid Membrane of Extremophiles. 渗透介导的极端微生物脂膜适应的分子研究。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-20 DOI: 10.1002/asia.202500590

Nirupma Rani, Venkatesh Nagaraj, Snehasis Daschakraborty

{"title":"Molecular Insights into Osmolyte-Mediated Adaptation of Lipid Membrane of Extremophiles.","authors":"Nirupma Rani, Venkatesh Nagaraj, Snehasis Daschakraborty","doi":"10.1002/asia.202500590","DOIUrl":"10.1002/asia.202500590","url":null,"abstract":"Extremophiles survive and thrive in extreme conditions on Earth, which pose challenges to their survivability. Osmotic stress, caused by different extreme conditions, such as water loss due to evaporation in hot and dry conditions, osmotic imbalance due to hypersalinity or excessive pressure, and freeze-drying, causes water loss, which severely affects cell membranes by altering the physicochemical properties of the lipid bilayer. While the organisms employ various adaptive strategies, osmolyte-mediated adaptation (OMA) plays a crucial role in maintaining membrane stability under desiccation. Osmolytes such as sugars, polyols, and amino acids function as molecular stabilizers by regulating hydration, preventing deleterious phase transitions, and modulating lipid packing. While the protective roles of osmolytes in stabilizing cellular membranes are well documented in the literature, the molecular mechanism remains less explored. This article focuses on the molecular mechanism underlying OMA of the lipid bilayer under desiccation stress. We have extensively reviewed the experimental studies on OMA in lipid membranes and highlighted molecular dynamics simulation studies, including contributions from our group. We have finally discussed the future research directions in this area and their broader applications in biotechnology and astrobiology.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00590"},"PeriodicalIF":3.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Competitive Relaxation Pathways of Dibenzophenanthroline Isomer Emission: Charge-Transfer, Excimer Formation. 二苯并菲罗啉异构体发射的竞争弛豫途径：电荷转移，准分子形成。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-20 DOI: 10.1002/asia.202500658

Yichen Zhou, Junxiang Huang, Animesh Ghosh, Andrew C Grimsdale, Saran Long, Qi Tao, Gagik G Gurzadyan

{"title":"Competitive Relaxation Pathways of Dibenzophenanthroline Isomer Emission: Charge-Transfer, Excimer Formation.","authors":"Yichen Zhou, Junxiang Huang, Animesh Ghosh, Andrew C Grimsdale, Saran Long, Qi Tao, Gagik G Gurzadyan","doi":"10.1002/asia.202500658","DOIUrl":"10.1002/asia.202500658","url":null,"abstract":"The photophysical properties and excited-state dynamics of the nonlinear heteroacene derivative DBP6 (bis-phenylethynyl-substituted dibenzophenanthroline) were systematically investigated through steady-state spectroscopy, time-resolved fluorescence measurements, and density functional theory (DFT) calculations. This study focuses on the competitive relaxation pathways after excitation to the lowest excited band of phenanthroline, that is, charge-transfer (CT), and intramolecular benzene excimer formation, which govern its dual-emission behavior. After excitation of the lowest excited band of dibenzophenanthroline, with λexc = 500 nm DBP6 in DCM exhibits dominant excimer emission at 570 nm with a long-lived fluorescence lifetime of 12 ns. This emission is attributed to stable π-π interactions between side phenyl rings. In contrast, excitation λexc = 440 nm leads, in addition to excimer formation, also to weak S1 emission at 480 nm (t = 0.34 ns). Higher-energy excitation λexc < 370 nm reveals ultrafast CT state formation as an intermediate bridging S1 depopulation and excimer generation. Solvent polarity-dependent studies demonstrate a progressive red-shift in S1 emission (455 nm in toluene to 515 nm in ethanol) confirming CT state stabilization in polar environments. DFT simulations corroborate experimental results, predicting S1 emission at 495 nm. By varying excitation wavelength and solvent polarity, DBP6's dual emission can be tuned, highlighting its potential for ratiometric sensing, stable organic light-emitting diodes (OLEDs), and energy conversion systems. This work advances the understanding of nonlinear heteroacenes and provides a framework for designing optoelectronic materials with tailored excited-state interactions.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00658"},"PeriodicalIF":3.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Small Molecule Inhibitors Targeting the Bacterial Lipoprotein Transport System (Lol) in Gram-Negative Bacteria. 针对革兰氏阴性菌细菌脂蛋白转运系统（Lol）的小分子抑制剂研究进展。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-19 DOI: 10.1002/asia.202500350

Saemee Song, Su Yong Shim

{"title":"Advances in Small Molecule Inhibitors Targeting the Bacterial Lipoprotein Transport System (Lol) in Gram-Negative Bacteria.","authors":"Saemee Song, Su Yong Shim","doi":"10.1002/asia.202500350","DOIUrl":"https://doi.org/10.1002/asia.202500350","url":null,"abstract":"The escalating threat of antimicrobial resistance (AMR) necessitates the urgent development of novel antibiotics, particularly those against multidrug-resistant gram-negative bacteria. These pathogens possess formidable structural defenses, including an impermeable outer membrane (OM) and robust efflux pumps, which hinder antibiotic efficacy. A promising therapeutic target is the lipoprotein transport system (Lol), which is essential for bacterial viability. The LolABCDE complex ensures the precise localization of lipoproteins, which is crucial for maintaining outer membrane integrity and cell survival. Disruption of this system results in severe structural and functional defects that lead to bacterial cell death. This review explores the recent advances in small-molecule inhibitors targeting the Lol system and examines the mechanisms of LolABCDE function, along with the structural and biochemical characteristics of its components. We also summarize the progress made in the discovery and optimization of inhibitors, including their modes of action, resistance mechanisms, and therapeutic potential. Despite significant progress, challenges, such as limited drug permeability and emerging resistance, continue to hinder therapeutic success. Overcoming these challenges necessitates strategies to enhance inhibitor selectivity and bypass the intrinsic defense mechanisms of gram-negative bacteria. This review aims to provide insights into the potential of targeting the Lol system as a novel strategy for combating antimicrobial resistance and developing effective therapies against gram-negative bacterial infections.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00350"},"PeriodicalIF":3.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Ruthenium and Palladium Supported on Copper Materials in Selective Synthesis of N-Benzylanilinyl-Benzoimidazole and Benzoimidazoquinazoline Derivatives. 钌钯负载铜材料在n -苄基苯胺基苯并咪唑和苯并咪唑喹唑啉衍生物选择性合成中的应用。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-19 DOI: 10.1002/asia.202500398

Xiaoyong Chen, Bin Pan, Anruo Mao, Jiahao Li, Dawei Wang

引用次数: 0

Uniform Spray-Coated Flexible SERS Substrates for Enhanced Molecular Detection. 增强分子检测的均匀喷涂柔性SERS衬底。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-19 DOI: 10.1002/asia.202500405

Shen Wang, Zhaoxin Wang, Xiaoxu Cao, Gang Wang, Rongshen Guo, Yemawaysh Zewdie, Shengkai Li, Liang Zhang, Qian Dong, Zhuo Chen

{"title":"Uniform Spray-Coated Flexible SERS Substrates for Enhanced Molecular Detection.","authors":"Shen Wang, Zhaoxin Wang, Xiaoxu Cao, Gang Wang, Rongshen Guo, Yemawaysh Zewdie, Shengkai Li, Liang Zhang, Qian Dong, Zhuo Chen","doi":"10.1002/asia.202500405","DOIUrl":"https://doi.org/10.1002/asia.202500405","url":null,"abstract":"Regulating uniformity and stability of substrates remains a key challenge in developments of flexible surface enhanced Raman spectroscopy (SERS) sensors. Herein, we fabricated a flexible SERS platform by integrating ultra-stable nitrogen-doped graphite-coated gold nanoparticles (Au@NG) with a polydimethylsiloxane (PDMS) film via optimized microarray spray-coating techniques, forming a composite substrate denoted as Au@NG@PDMS. The structure and chemical stability of the Au@NG nanoparticles were confirmed by TEM and Raman spectroscopy. The presence of a thin, nitrogen-doped graphite shell effectively protected the Au core against acidic, alkaline, and oxidative environments. Benefiting from the superior mechanical flexibility of PDMS, the Au@NG@PDMS substrate maintained excellent SERS signal reproducibility under repeated bending and stretching cycles. Furthermore, we demonstrated that adjusting the solvent evaporation rate by selecting solvents in spraying process significantly improved the uniformity, reproducibility, and overall SERS performance of the substrate. Using this platform, we achieved highly sensitive and quantitative detection of crystal violet across a concentration range from 10 nM to 10 µM and successfully identified trace levels (20 ng/mL) of thiram residues directly on the surface of apples. The resulting flexible SERS substrate exhibits outstanding structural stability, signal uniformity, and surface conformability making it highly promising for practical applications in on-site pesticide residue detection in agricultural monitoring.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00405"},"PeriodicalIF":3.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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1,7-Dithienyl and 3,5-Di-tert-Butyl Substituted aza-BODIPY with the Large Stokes Shift. 1,7-二硫乙烯基和3,5-二叔丁基以大斯托克斯位移取代偶氮偶氮。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-19 DOI: 10.1002/asia.202500495

Jie Lu, Ran Li, Zhengpeng Qin, Yue Shen, Xin-Dong Jiang

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Nanoscopic [(NH₄)₆V₁₀O₂₈.6H₂O]_n Where n = 27882-90189 Soft-Oxometalates-Based Photocatalyst for Conversion of Benzene to Phenol under Ambient Conditions. 纳米级[(NH4)6V10O28.6H2O]n其中n = 27882-90189软金属氧酸盐基光催化剂在环境条件下苯转化为苯酚

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-19 DOI: 10.1002/asia.70120

Nidhi Kumari, Joyeeta Lodh, Andrew C Bates, Kateryna Kostenkova, Debbie C Crans, Soumyajit Roy

{"title":"Nanoscopic [(NH4)6V10O28.6H2O]n Where n = 27882-90189 Soft-Oxometalates-Based Photocatalyst for Conversion of Benzene to Phenol under Ambient Conditions.","authors":"Nidhi Kumari, Joyeeta Lodh, Andrew C Bates, Kateryna Kostenkova, Debbie C Crans, Soumyajit Roy","doi":"10.1002/asia.70120","DOIUrl":"https://doi.org/10.1002/asia.70120","url":null,"abstract":"In a quest to find new routes for the functionalization of very strong C─H bonds, such as those found in benzene, we have reported nanoscopic soft-oxometalates-based photocatalytic oxidation of benzene to phenol by dioxygen (O2) in acetonitrile-water (1:1) solvent under visible light irradiation at room temperature using Eosin Y (EY) as a photosensitizer and (NH4)6V10O28.6H2O as the pre-catalyst. Studies reveal that photosensitizer Eosin Y (EY) transfers an electron to the catalyst VV 10O28 6- under visible light irradiation for in- situ generation of H2O2 from O2, which is followed by efficient hydroxylation of benzene to phenol with a high turnover number of 156.8. The present study is a blueprint for efficient C─H activation via a synergistic combination of photocatalysis and vanadium catalysis, giving excellent yield and selectivity.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e70120"},"PeriodicalIF":3.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Luminescent Benzoselenadiazole Derivatives: Comparison with Benzothiadiazoles, Properties, Applications, and Trends. 发光苯并硒二唑衍生物的研究进展：与苯并噻唑的比较、性质、应用及发展趋势。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-06-19 DOI: 10.1002/asia.202500004

Brenno A D Neto, John Spencer, Alexandre A M Lapis

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