Chemistry - An Asian Journal最新文献_第9页

Cover Feature: Structural Effect of N-7 Alkylation in 6-Chloropurine on Cu (II) Binding: Effect of Anions and Magnetic Studies (Chem. Asian J. 2/2025)

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-17 DOI: 10.1002/asia.202580203

Subhra Jyoti Panda, Suraj Kumar Agrawalla, Chandra Shekhar Purohit

引用次数: 0

Silver N-Heterocyclic Biscarbene Complexes: Potent Inhibitors of Thioredoxin Reductase with Anticancer Activity in Vitro and in Vivo. 银n -杂环比卡宾复合物：体内和体外具有抗癌活性的硫氧还蛋白还原酶的有效抑制剂。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-17 DOI: 10.1002/asia.202401672

Igor V Esarev, Chengnan Wu, Anna A Kirsanova, Sebastian Türck, Petra Lippmann, Peter G Jones, Maria V Babak, Ingo Ott

{"title":"Silver N-Heterocyclic Biscarbene Complexes: Potent Inhibitors of Thioredoxin Reductase with Anticancer Activity in Vitro and in Vivo.","authors":"Igor V Esarev, Chengnan Wu, Anna A Kirsanova, Sebastian Türck, Petra Lippmann, Peter G Jones, Maria V Babak, Ingo Ott","doi":"10.1002/asia.202401672","DOIUrl":"10.1002/asia.202401672","url":null,"abstract":"Silver N-heterocyclic carbene (NHC) complexes are known to form biscarbene species from monocarbene analogs in protic polar solvents. However, the effect of the respective species of silver NHC complexes on their biological activity against bacteria or cancer cells has not been systematically explored, either in vitro or in vivo. The direct and simple conversion of monocarbene silver N-heterocyclic carbene (NHC) halide complexes (NHC)AgX, (X=Cl, Br) 1 a/b-5 a/b to their biscarbene analogues (NHC)2AgX 1 c/d-5 c/d is reported. The biscarbenes demonstrated generally lower activity against bacteria compared to the monocarbene complexes; however, both types showed similar activity against tumor cells and a non-tumor reference cell line. Selected mono- and biscarbene complexes 3 a and 3 c showed similar strong inhibitory effects on thioredoxin reductase in vitro and in cellulo and had a similar level of metal uptake into A549 cells. The subsequent evaluation of their effects in vivo revealed relatively low toxicity and high antitumoral efficacy of both selected complexes in mice. The biscarbene silver organometallic 3 c showed the most pronounced reduction of tumor growth in animals. The results indicate that both (NHC)AgX and (NHC)2AgX complexes could trigger their anticancer activity as biscarbene complexes, making this the preferred form for future anticancer metallodrug development.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401672"},"PeriodicalIF":3.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Feature: Platinum Stabilises a Molten-Globule Conformation of a Small Globular Cytosolic Protein SUMO1 (Chem. Asian J. 2/2025)

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-17 DOI: 10.1002/asia.202580202

Suman Tiwari, Sri Rama Koti Ainavarapu

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Stabilization of Alkyltin γ-Keggin Clusters by 2, 5-Dihydroxyterephthalate Ligands. 2,5 -二羟基对苯二甲酸酯配体对烷基锡γ-Keggin簇的稳定作用

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-17 DOI: 10.1002/asia.202401290

Qian Zhou, Yu Zhu, Peng Li, Wei-Hui Fang, Dong-Sheng Li

{"title":"Stabilization of Alkyltin γ-Keggin Clusters by 2, 5-Dihydroxyterephthalate Ligands.","authors":"Qian Zhou, Yu Zhu, Peng Li, Wei-Hui Fang, Dong-Sheng Li","doi":"10.1002/asia.202401290","DOIUrl":"10.1002/asia.202401290","url":null,"abstract":"The Keggin clusters are one kind of the most representative molecular structures in the field of metal-oxo clusters. Although the different types of Keggin clusters with various components were reported, the research about γ-Keggin isomer remains less developed. This is ascribed to the difficulty in obtaining the stable pure γ-Keggin cluster for the structural isomerization. In this study, we adopted a ligand stabilization strategy to get the stable pure γ-Keggin structure [(n-BuSn)12(NaO4)(OH)24](DHTA)2.5 ⋅ DMF ⋅ H2O (CTGU-SnC-10). Different from the reported mixed neutral-charge alkytin β, γ isomers, the NaSn12 cluster in the CTGU-SnC-10 is a cationic pentavalent γ-Keggin structure without isomerization. Besides the electrostatic interaction, the NaSn12 cationic clusters have a strong hydrogen-bond interaction with polycarboxylic ligands, resulting in the formation of a 3D hydrogen-bonded framework. These are conducive to stabilizing the γ-Keggin structure. Moreover, the CTGU-SnC-10 exhibits high hydrophobicity and a small band gap due to the organic functional groups of the framework.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401290"},"PeriodicalIF":3.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naphthalimide and Carbazole Based Mechanochromic Molecular Dyads and Triads for Selective Lysosome Imaging. 基于萘酰亚胺和咔唑的机械变色分子二联体和三联体用于选择性溶酶体成像。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-16 DOI: 10.1002/asia.202401386

Akkarakkaran Thayyil Muhammed Munthasir, Poonam Rani, Pandi Dhanalakshmi, Silvano Geremia, Neal Hickey, Pakkirisamy Thilagar

{"title":"Naphthalimide and Carbazole Based Mechanochromic Molecular Dyads and Triads for Selective Lysosome Imaging.","authors":"Akkarakkaran Thayyil Muhammed Munthasir, Poonam Rani, Pandi Dhanalakshmi, Silvano Geremia, Neal Hickey, Pakkirisamy Thilagar","doi":"10.1002/asia.202401386","DOIUrl":"10.1002/asia.202401386","url":null,"abstract":"In this study, we report the design and development of a stable fluorescent probe that is selectively localized in the cytosol of Hela cells. We designed two probes, 1 and 2, with D-π-A (carbazole (Cbz)-vinyl-naphthalimide (NPI)) and A-π-D-π-A (NPI-vinyl-Cbz-vinyl-NPI) architecture, respectively. Probes 1 and 2 exhibit broad photoluminescence (PL) spectra ranging from green (550 nm) to far-red (800 nm) in solutions and aggregated states. In the solid-state, the PL of these probes shows a bathochromic shift, which can be attributed to intermolecular interactions. In a water-rich medium, Probe 1, with a single NPI moiety, shows aggregation-caused quenching (ACQ) but retains a moderate quantum yield of 13.7 % (Φsoln=61.4 %). On the other hand, probe 2, with two NPI units, showed aggregation-induced enhanced emission AIEE, where the PLQY is increased nearly 4 times (Φsoln=3.5 %, Φagg=12.8 %). In-vitro cell studies revealed that these probes are non-toxic and effectively stain cells in green and red channels. Notably, Probe 1 demonstrated excellent cellular uptake and selectivity for lysosome, with a Pearson overlap coefficient of 0.91.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401386"},"PeriodicalIF":3.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of K-doping on Activation in Co-Free Li-Rich Cathodes. k掺杂对无co富锂阴极活化的影响。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-16 DOI: 10.1002/asia.202400185

Trent Seaby, Tongen Lin, Xia Huang, Ardeshir Baktash, Lianzhou Wang

{"title":"The Effect of K-doping on Activation in Co-Free Li-Rich Cathodes.","authors":"Trent Seaby, Tongen Lin, Xia Huang, Ardeshir Baktash, Lianzhou Wang","doi":"10.1002/asia.202400185","DOIUrl":"https://doi.org/10.1002/asia.202400185","url":null,"abstract":"The activation mechanism of Li-rich cathode has been discussed for many years, yet there is still debate on different theories. Potassium doping can assist the investigation on activation mechanism through its unique function in terms of blocking TM migration during activation. K-doping works by occupying Li sites even after Li has been extracted, increasing stability by blocking transition metals from migrating into these sites, which can help us distinguish the pathway of activation. We use in-situ XRD to show that K-doping significantly lowers the rate of transition metal migration during initial charging, and that this is correlated with less activation extent. However, the ex-situ XAS results show that anionic redox is more reversible in the K-doped material. These results cannot be easily explained by existing theories alone; therefore, we propose that K-doping hinders TM migration during activation and therefore favours a Reductive Coupling Mechanism over a dynamic TM migration mechanism. These findings have significant practical and theoretical implications for the development of Lithium-Rich cathodes.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202400185"},"PeriodicalIF":3.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Cationic Bolaamphiphiles for Protein and DNA Binding, Gene Delivery, and Antimicrobial Applications. 用于蛋白质和DNA结合、基因传递和抗菌应用的新型阳离子亲水分子。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-16 DOI: 10.1002/asia.202401582

Pabitra Mondal, Sadhana Roy, Dipanwita Patra, Somdeb Bose Dasgupta, Joykrishna Dey

{"title":"Novel Cationic Bolaamphiphiles for Protein and DNA Binding, Gene Delivery, and Antimicrobial Applications.","authors":"Pabitra Mondal, Sadhana Roy, Dipanwita Patra, Somdeb Bose Dasgupta, Joykrishna Dey","doi":"10.1002/asia.202401582","DOIUrl":"10.1002/asia.202401582","url":null,"abstract":"In this study, we have designed and developed a cationic bolaform C12-(2,3-dihydroxy-N, N-dimethyl-N-(2-ureidoethyl)propan-1-aminium chloride)2 (C12(DDUPAC)2) that is derived from biocompatible molecules. The bolaform C12(DDUPAC)2 has hydroxyl (OH) functionality at both the cationic head groups. The impact of head group structure on the self-assembly and effectiveness of gene transfection and antimicrobial activity was investigated and compared with that of the hydrochloride salt C12-(N, N-dimethyl-N-(2-ureidoethan-1-aminium chloride)2 (C12(DUAC)2) of its precursor molecule. The formation of spherical as well as rod-like self-assembled structures was found to occur above a relatively low critical aggregation concentration (CAC) by the bolaforms. The results of calorimetric measurements demonstrated thermodynamically favorable aggregation in water. Interaction studies of the cationic bolaforms with the calf thymus DNA revealed stronger binding of C12(DDUPAC)2 in comparison to C12(DUAC)2, which explained higher in vitro gene transfection efficiency of C12(DDUPAC)2 than C12(DUAC)2. Both bolaforms interact weakly with the bovine serum albumin protein. MTT-based in vitro cytotoxicity assay was performed and both bolaforms were found to have marginal cytotoxicity. Further, both bolaforms exhibit advantageous antibacterial activity against E. coli and potent antifungal activity against Fusarium oxysporum at high dosages.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401582"},"PeriodicalIF":3.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Humic Acid Glazed Magnetite Material for the Adsorptive Desulfurization of Model Fuel. 腐植酸釉面磁铁矿材料吸附脱硫模型燃料。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-16 DOI: 10.1002/asia.202401472

M Christina Nilavu, A Santhana Krishna Kumar, Himanshu Aggarwal, N Rajesh

{"title":"Humic Acid Glazed Magnetite Material for the Adsorptive Desulfurization of Model Fuel.","authors":"M Christina Nilavu, A Santhana Krishna Kumar, Himanshu Aggarwal, N Rajesh","doi":"10.1002/asia.202401472","DOIUrl":"10.1002/asia.202401472","url":null,"abstract":"Impact of climate change that stems from gaseous emissions require sustainable materials to eliminate sulfur. This study involves the modification of humic acid with magnetite nanoparticles (Fe₃O₄ NPs) by a microwave-assisted synthesis of an absorbent with reasonable pore volume and diameter for elimination of thiophenic compounds from fuel. The magnetic nano adsorbent designated Fe3O4@HA was characterized using advanced spectroscopic techniques, while their structure and morphology were analyzed through DLS, XPS, XRD, FT-IR, TGA, FESEM-EDX, VSM, and BET-N2 techniques. These findings indicated that the synthesized magnetic nano adsorbent (Fe3O4@HA) has appropriate oxygen functionalities with a specific surface area of 335 m2 g-1 and a mesoporous structure with a pore diameter of 9 nm. The adsorption capacity for sulfur was determined to be 62.73 mg g-1. The kinetic and isotherm models, coupled with thermodynamic characteristics, confirmed that the adsorption of sulfur onto the adsorbent was spontaneous, exothermic, and followed pseudo-first-order kinetics. The adsorbent material demonstrated reusability for sulfur adsorption for up to six cycles. The economic and environmental advantages of the preparation process provide humic acid modified with magnetite nanoparticles (Fe₃O₄ NPs) as an interesting candidate for real-world applications.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401472"},"PeriodicalIF":3.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemistry and Gold Catalysis: Unusual Allies in Redox Mediated Organic Reactions. 电化学和金催化：氧化还原介导的有机反应中的异常盟友。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-15 DOI: 10.1002/asia.202401048

Chandrasekar Praveen, Giuliano C Clososki

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Photo-Driven Direct Construction of Imidazolidines from Anilines and Paraformaldehyde and Its Application in Polyoxymethylene Plastics Usage. 苯胺和多聚甲醛光驱动直接合成咪唑烷及其在聚甲醛塑料中的应用。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-01-15 DOI: 10.1002/asia.202401742

Sheng Bi, Xu-Dong Mao, Alban Schmoll, Xiao-Feng Wu

引用次数: 0