{"title":"An overlapping phenotype between megalencephaly-capillary malformation and Diffuse Capillary Malformation with Overgrowth: expanding the PIK3CA-related overgrowth spectrum.","authors":"Filippo Toaiari, Samantha F Berti, Michele Lanzetti, Camilla Salvini, Antonella Cecconi","doi":"10.23736/S2784-8671.25.08276-3","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08276-3","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 5","pages":"461-463"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessia Paganelli, Andrea Michelerio, Maria C Collina, Maria A Pilla, Marco Spadafora, Caterina Longo, Annunziata Dattola, Antonio G Richetta, Giovanni Pellacani, Claudia Pezzini, Victor D Mandel, Francesca DI Tullio, Andrea Conti, Alfonso Motolese, Andrea Marani, Barbara DE Pace, Andrea Megna, Alessandra G Condorelli, Federica Arginelli, Flavia Persechino, Federico Garbarino, Luca Ambrosio, Emanuele Scala, Camilla Vassallo, Alberico Motolese
{"title":"Clinical management of pigmented purpuric dermatoses: evidence from a survey among the Study Group on Cutaneous Vascular Diseases of the Italian Society of Dermatology and Venereology.","authors":"Alessia Paganelli, Andrea Michelerio, Maria C Collina, Maria A Pilla, Marco Spadafora, Caterina Longo, Annunziata Dattola, Antonio G Richetta, Giovanni Pellacani, Claudia Pezzini, Victor D Mandel, Francesca DI Tullio, Andrea Conti, Alfonso Motolese, Andrea Marani, Barbara DE Pace, Andrea Megna, Alessandra G Condorelli, Federica Arginelli, Flavia Persechino, Federico Garbarino, Luca Ambrosio, Emanuele Scala, Camilla Vassallo, Alberico Motolese","doi":"10.23736/S2784-8671.25.08243-X","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08243-X","url":null,"abstract":"<p><strong>Background: </strong>Pigmented purpuric dermatoses (PPD) are a group of chronic, benign skin conditions with limited evidence-based data regarding their diagnosis and management. The aim of our work was to evaluate the clinical practices of dermatologists in managing PPD, focusing on patient presentation, treatment preferences, and the need for further diagnostic evaluations.</p><p><strong>Methods: </strong>We utilized a survey-based design for the present study. The survey was distributed to the Study Group on Cutaneous Vascular Diseases and Skin Ulcers of the Italian Society of Dermatology and Venereology. The survey collected data on the number of patients evaluated weekly, the proportion of patients requesting treatment, preferred therapeutic approaches, and indications for additional diagnostic tests.</p><p><strong>Results: </strong>Twenty-four clinicians from 11 centers participated. Respondents reported managing an average of 5 PPD cases per week, with treatment required in approximately 50% of cases, while the remainder were incidental findings during evaluations for other dermatological conditions. Skin moisturizers and topical corticosteroids (tCS) were universally recommended as first-line treatments. Additional therapies included zinc oxide cream, compression stockings, and flavonoid-based oral supplements. Further diagnostic workups, such as leg Doppler ultrasound, skin biopsy, and blood tests, were considered necessary only in selected patients based on clinical presentation and comorbidities.</p><p><strong>Conclusions: </strong>Moisturizers and tCS are the cornerstone of PPD treatment, supplemented by tailored therapies and diagnostic evaluations. These findings highlight the need for standardized, evidence-based guidelines to optimize the management of PPD.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 5","pages":"406-412"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Bazzacco, Enrico Zelin, Vanessa Mazzoletti, Cinzia Buligan, Enrico Pegolo, Agnese Zanus-Fortes, Marco Cotrufo, Davide Pecori, Carlo Tascini, Giuseppe Stinco, Enzo Errichetti
{"title":"Dermoscopic clues of cutaneous sarcoidosis on skin of color masking a systemic involvement.","authors":"Giulia Bazzacco, Enrico Zelin, Vanessa Mazzoletti, Cinzia Buligan, Enrico Pegolo, Agnese Zanus-Fortes, Marco Cotrufo, Davide Pecori, Carlo Tascini, Giuseppe Stinco, Enzo Errichetti","doi":"10.23736/S2784-8671.25.08319-7","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08319-7","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 5","pages":"463-465"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of human eye in resource-limited settings: preserving essential diagnostic skills in dermatology.","authors":"Rebecca Donadoni, Valeria Brazzelli","doi":"10.23736/S2784-8671.25.08242-8","DOIUrl":"10.23736/S2784-8671.25.08242-8","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"454-455"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enrico Bocchino, Maria Mannino, Azzurra Iacoangeli, Alessandra Gaeta, Alessandro DI Stefani, Pietro Sollena, Ketty Peris
{"title":"Granuloma faciale-like eruption associated with mogamulizumab treatment.","authors":"Enrico Bocchino, Maria Mannino, Azzurra Iacoangeli, Alessandra Gaeta, Alessandro DI Stefani, Pietro Sollena, Ketty Peris","doi":"10.23736/S2784-8671.25.08322-7","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08322-7","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Topical 5-fluorouracil as cytoreductive therapy for conservative surgery in squamous cell carcinoma of the face.","authors":"Davide Bertolla, Federico Tartari, Elisa Marzola, Sebastiano Posenato, Alessandro Borghi, Andrea Conti","doi":"10.23736/S2784-8671.25.08291-X","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08291-X","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gaetano Licata, Luca Damiani, Graziella Babino, Paolino Franzese, Maria M Nicoletti, Giuseppe Argenziano, Caterina M Giorgio
{"title":"Bullous pemphigoid induced by linagliptin: a case series of 17 patients in a rare disease referral center.","authors":"Gaetano Licata, Luca Damiani, Graziella Babino, Paolino Franzese, Maria M Nicoletti, Giuseppe Argenziano, Caterina M Giorgio","doi":"10.23736/S2784-8671.25.08381-1","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08381-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Davide Bertolla, Federico Tartari, Andrea Marani, Alessandro Borghi, Andrea Conti
{"title":"Innovation in the treatment of cutaneous leishmaniasis: single-step surgical approach with dermal substitutes.","authors":"Davide Bertolla, Federico Tartari, Andrea Marani, Alessandro Borghi, Andrea Conti","doi":"10.23736/S2784-8671.25.08244-1","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08244-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rapid control of chronic spontaneous urticaria with dupilumab in a patient with severe atopic dermatitis.","authors":"Mattia Minghini, Natale Schettini, Chiara Bocchi, Giulia Odorici, Alessandro Borghi","doi":"10.23736/S2784-8671.25.08309-4","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08309-4","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne Sofie Frølunde, Aska Drljevic-Nielsen, Christian Vestergaard
{"title":"Atopic dermatitis, hypertension, and cardiovascular risk: an appraisal of the evidence.","authors":"Anne Sofie Frølunde, Aska Drljevic-Nielsen, Christian Vestergaard","doi":"10.23736/S2784-8671.25.08041-7","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08041-7","url":null,"abstract":"<p><p>Atopic dermatitis is the most common chronically or chronically relapsing inflammatory skin disease, characterized by intense pruritus, eczematous lesions, and a significant disease burden. Emerging evidence in recent years suggests that atopic dermatitis and the associated chronic systemic inflammation have health implications beyond the skin. For psoriasis, another chronic inflammatory skin disease, the association with cardiovascular diseases (CVDs) is well-established. Recent studies have demonstrated a similar association between atopic dermatitis and CVDs such as hypertension, atherosclerosis, myocardial infarction, and major cardiovascular events. CVDs are the leading cause of death in the USA and Europe, and information about a heart-healthy lifestyle for patients at heightened risk is important. This narrative review focuses on recent studies investigating the association between atopic dermatitis and hypertension, ischemic heart disease including myocardial infarction and coronary heart disease, cardiac arrhythmias, and the association between atopic dermatitis, cardiovascular diseases, and a sedentary lifestyle. The associations between atopic dermatitis and CVDs appear to be more pronounced for moderate to severe disease across all included cardiovascular conditions in this review, suggesting a potential impact from systemic inflammation linked to atopic dermatitis. However, it remains uncertain whether the increased cardiovascular risk is directly attributable to the inflammatory nature of atopic dermatitis or may result from reduced physical activity commonly seen in these patients.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}