Italian Journal of Dermatology and Venereology最新文献

{"title":"The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia.","authors":"Woo C Tay, Suzanne W Cheng, Joyce S Lee, Carlos Clavel, Etienne C Wang","doi":"10.23736/S2784-8671.25.08232-5","DOIUrl":"10.23736/S2784-8671.25.08232-5","url":null,"abstract":"<p><p>Hair loss in both men and women significantly impact quality of life and often has modest treatment outcomes. Recently, microtrauma, which involves small, intentional skin injuries, has emerged as a promising method to stimulate hair growth through immunomodulation in non-scarring alopecias. This review explores the pathogenesis of hair loss, the mechanisms behind microtrauma, various methods of inducing it, and their efficacy in treating non-scarring alopecia. Hair follicles undergo cyclic phases of growth, regression, and rest, influenced by microenvironmental factors, including immune cells. Procedures utilizing microtrauma can promote hair regrowth by manipulating immune cells through wound healing responses, increasing growth factor release, and enhancing blood circulation. Examples of microtrauma include microneedling, fractional and non-fractional lasers, contact immunotherapy, low-level laser therapy (LLLT), and platelet-rich plasma (PRP) injections. Microneedling promotes stem cell activation and the expression of hair growth-related genes. Iontophoresis enhances drug delivery. Lasers induce controlled tissue injury leading to regeneration that may promote transitions in hair growth phases. Photobiomodulation may stimulate cellular activity and prolong growth phases. Contact immunotherapy induces allergic immune responses that promote hair regrowth in alopecia areata, while PRP expedites wound healing and tissue restoration. In androgenetic alopecia, microneedling, lasers, LLLT, and PRP have shown efficacy in increasing hair density and thickness. For alopecia areata, contact immunotherapy, and combination therapies involving microneedling and lasers have demonstrated positive outcomes. Limited studies on telogen effluvium suggest that microneedling and PRP can improve hair density. Microtrauma-based treatments offer promising strategies for hair regeneration. Continued research is necessary to enhance therapeutic options for non-scarring alopecia.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"438-452"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple sentinel lymph node biopsies in a patient with multiple melanomas: report of a one-time surgical session.","authors":"Gabriele Roccuzzo, Silvia Borriello, Simone Ribero, Pietro Quaglino, Adriana Lesca, Franco Picciotto","doi":"10.23736/S2784-8671.25.08230-1","DOIUrl":"10.23736/S2784-8671.25.08230-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"453-454"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An atypical forehead nodule: a case report of Kimura disease in a Caucasian female.","authors":"Umberto Santaniello, Elena Zappia, Matteo G Brizio, Stefania G Passerini, Federica Santoro, Simone Ribero, Pietro Quaglino","doi":"10.23736/S2784-8671.25.08335-5","DOIUrl":"10.23736/S2784-8671.25.08335-5","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"465-466"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatological adverse events during hematological and oncological therapies (Bruton's tyrosine kinase inhibitors and mogamulizumab): an Italian retrospective multicenter study.","authors":"Michela Starace, Stephano Cedirian, Luca Rapparini, Corrado Zengarini, Laura Gandolfi, Giulio Gualdi, Fabio Lobefaro, Pietro Sollena, Pietro Quaglino, Simone Ribero, Martina Merli, Elisabetta Fulgione, Paola Vitiello, Giovanni Paolino, Franco Rongioletti, Laura Calabrese, Martina D'Onghia, Elisa Cinotti, Ilaria Proietti, Davide Fattore, Bianca M Piraccini, Alessandro Pileri","doi":"10.23736/S2784-8671.25.08294-5","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08294-5","url":null,"abstract":"<p><strong>Background: </strong>Bruton's Tyrosine Kinase Inhibitors (BTKIs) and mogamulizumab have revolutionized the treatment of hematologic malignancies, yet they are frequently associated with dermatologic adverse events (dAEs) that can impact patient quality of life and adherence. The aim is to evaluate the incidence, clinical features, and management of dAEs associated with BTKIs and mogamulizumab across multiple Italian dermatology centers.</p><p><strong>Methods: </strong>We conducted a retrospective, multicenter study involving 80 patients treated with BTKIs or mogamulizumab from January to December 2024. Patients were stratified into three cohorts: mogamulizumab (MOG), ibrutinib (IBR), and other BTKIs. dAEs were assessed for type, location, severity (CTCAE v5.0), duration, and treatment outcomes.</p><p><strong>Results: </strong>Eczema-like rashes were most frequent in BTKI-treated patients (43.2% in IBR; 22.2% in other BTKIs), while mogamulizumab was primarily associated with morbilliform rashes (36%). The mean duration of dAEs was under six months across all cohorts, with most cases graded as mild. Topical corticosteroids and emollients were the mainstay of treatment. Remission rates were 64% (MOG), 89.2% (IBR), and 83.3% (other BTKIs), with few cases of progression.</p><p><strong>Conclusions: </strong>dAEs are common but manageable side effects of BTKIs and mogamulizumab. Dermatologic surveillance and early treatment are crucial for optimizing patient outcomes. Multidisciplinary collaboration is essential to prevent misdiagnosis and treatment interruptions, especially in cases of mogamulizumab-associated rash.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 5","pages":"418-422"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 2023 American College of Rheumatology and European League Against Rheumatism antiphospholipid syndrome criteria: through the eyes of Dermatologists.","authors":"Cristina Sarda, Massimo Radin, Silvia G Foddai, Simone Ribero, Savino Sciascia","doi":"10.23736/S2784-8671.25.08207-6","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08207-6","url":null,"abstract":"<p><p>The 2023 American College of Rheumatology and European League Against Rheumatism (ACR/EULAR) antiphospholipid syndrome (APS) criteria represent a significant stride forward in the holistic understanding of APS, emphasizing the role of interdisciplinary approaches in the management of this complex autoimmune condition. For dermatologists, these criteria reinforce the importance of recognizing cutaneous manifestations as integral components of the APS management framework. By bridging the gap between dermatologic and systemic observations, dermatologists can play a pivotal role in the early detection and management of APS, ultimately contributing to improved patient outcomes. As the field progresses, continued collaboration between dermatology and rheumatology will be essential in refining classification criteria and enhancing the quality of care for patients with APS.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 5","pages":"429-437"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ineffectiveness of albendazole in scabies.","authors":"Stefano Veraldi, Italo F Aromolo, Gianluca Nazzaro","doi":"10.23736/S2784-8671.25.08295-7","DOIUrl":"10.23736/S2784-8671.25.08295-7","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"463"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5% fluorouracil/salicylic acid treatment for recalcitrant warts in one child.","authors":"Martina Cavicchi, Nicola Lippolis, Caterina Longo","doi":"10.23736/S2784-8671.25.08252-0","DOIUrl":"10.23736/S2784-8671.25.08252-0","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"457-458"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classic Lichen planopilaris and pseudopelade of Brocq of the scalp: a retrospective study of epidemiological, histopathological and etiopathogenetic differences.","authors":"Giuseppe Gallo, Luca Mastorino, Luca Conti, Pietro Quaglino, Simone Ribero","doi":"10.23736/S2784-8671.25.08043-0","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08043-0","url":null,"abstract":"<p><strong>Background: </strong>Lichen planopilaris (LPP) and pseudopelade of Brocq (PPB) are lymphocytic scarring alopecias that commonly involve the scalp with alopecic patches and can be considered as a unique nosologic condition. The medical features of patients affected by scalp Lichen planopilaris were reviewed to identify demographic differences between the classic LPP (C-LPP) and the pseudopelade of Brocq variant (PB-LPP).</p><p><strong>Methods: </strong>A retrospective analysis of patients with classic Lichen planopilaris (C-LPP) and the pseudopelade of Brocq variant (PB-LPP) was conducted. Demographic and clinical data, results of trichoscopy and histopathology were analyzed.</p><p><strong>Results: </strong>Sixty patients with LPP were followed up from March 2020 to March 2023. The mean age of the population at the time of the analysis was 63.1 years, and the mean age at clinical or histological diagnosis of LPP was 60.1. The predominant sex was female. The clinical-histological diagnosis of PB-LPP was reported in four patients (6.7%), the remaining presented a variant of C-LPP. No significant differences between the two variants of LPP concerning mean patient age and age at diagnosis was found. PB-LPP was more frequent in the male gender than in the female gender. No difference was observed for concomitant autoimmune diseases.</p><p><strong>Conclusions: </strong>Our study confirms a prevalence of classic Lichen planopilaris in female patients and a predilection for the pseudopelade of Brocq LPP in the male patients. However, due to the low number of cases due to rarity of diseases, more studies are needed to confirm our data and hypotheses.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 5","pages":"393-397"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinic, dermoscopy and histology of Merkel cell carcinoma in a patient with a prior nodular melanoma on the ipsilateral limb.","authors":"Silvia Borriello, Umberto Santaniello, Matteo G Brizio, Paolo Fava, Rebecca Senetta, Francesco Cavallo, Orsola Crespi, Simone Ribero, Pietro Quaglino","doi":"10.23736/S2784-8671.25.08268-4","DOIUrl":"10.23736/S2784-8671.25.08268-4","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"459-461"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant treatment of secukinumab and ofatumumab in a psoriasis patient with multiple sclerosis.","authors":"Gioacchino Lucagnano, Luca Potestio, Fabrizio Martora, Ginevra Torta, Flavia Raia, Matteo Megna","doi":"10.23736/S2784-8671.25.08238-6","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08238-6","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}