Italian Journal of Dermatology and Venereology最新文献

{"title":"A unique case of Pseudomonas aeruginosa furunculosis.","authors":"Andrea Marani, Davide Bertolla, Alessandro Borghi, Andrea Conti","doi":"10.23736/S2784-8671.26.08543-9","DOIUrl":"10.23736/S2784-8671.26.08543-9","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"410-411"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral isotretinoin and acne clearance: the role of daily dosage in a real-world clinical setting.","authors":"Elisa Marzola, Emma Pedarzani, Giorgia Valpiani, Sofia Fraternale, Giulia Toni, Vincenzo Bettoli, Monica Corazza, Alessandro Borghi","doi":"10.23736/S2784-8671.26.08562-2","DOIUrl":"10.23736/S2784-8671.26.08562-2","url":null,"abstract":"<p><strong>Background: </strong>Complete acne resolution with oral isotretinoin has not been specifically addressed. We aimed to assess the achievement of acne clearance with particular focus on oral isotretinoin daily dosage.</p><p><strong>Methods: </strong>This single-center, retrospective study included a cohort of acne patients treated with oral isotretinoin at our Acne Clinic between January 2014 and December 2023. The key aspects investigated were the rate of patients who achieved acne clearance at face, chest and back, the incidence of adverse effects and the relevance of the daily oral isotretinoin dosage in relation to these two outcomes.</p><p><strong>Results: </strong>Of the 359 patients included (61.3% males, 38.7% females), 217, 61.6% of those with facial involvement, achieved complete clearance of face acne, 101 (46.1%) achieved clearance of back acne and 89 (75.4%) a complete recovery of chest acne. A mean daily dosage between >10 and 20 mg was associated with a higher probability of complete resolution of acne, especially at chest, compared to lower dosages. Mean daily doses higher than 20 mg were not associated with a greater probability of clearance compared to lower dosages, while they were associated with an increased side effects' occurrence.</p><p><strong>Conclusions: </strong>The daily dosage of oral isotretinoin does not appear to be a determining factor in achieving acne clearance, while it may influence the incidence of side effects. A mean daily dosage ranging from >10 to 20 mg may represent an optimal balance, ensuring therapeutic efficacy while limiting the risk of adverse events.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"380-387"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidradenitis suppurativa-associated squamous cell carcinoma: a systematic review of clinical, molecular, and risk factor insights.","authors":"Alberto Soto-Moreno, Lía Bejarano-Antonio, Javier León-Pérez, Daniel Muñoz-Barba, Alejandro Molina Leyva","doi":"10.23736/S2784-8671.26.08519-1","DOIUrl":"10.23736/S2784-8671.26.08519-1","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the pilosebaceous unit that can rarely harbor squamous cell carcinoma (SCC). Despite its clinical relevance, comprehensive characterization of HS-SCC - including risk factors, histological and molecular features, and outcomes - remains limited.</p><p><strong>Methods: </strong>A systematic review of the literature was performed to identify all published cases of HS-associated SCC. Data on demographics, HS features, tumor characteristics, human papillomavirus (HPV) status, treatments, and outcomes were extracted to identify risk phenotypes and prognostic factors.</p><p><strong>Results: </strong>A total of 174 cases were included. Most patients were male (78.4%), with a mean age of 53 years, and nearly all presented Hurley stage III HS affecting the lower trunk, predominantly the gluteal region. Tumors were generally large, often arising from sinus tract epithelium, and were commonly well-differentiated. HPV infection was detected in 28.6% of cases, predominantly HPV-16. Metastasis occurred in 54.3% of patients. Overall mortality was 52.8%, with mean survival until death of 11.9 months. Male sex, gluteal location, poor histologic differentiation, and presence of metastasis were associated with worse outcomes. Risk phenotypes include males >50 years, long-standing HS (>10 years), Hurley III disease with complex sinus tracts involving the lower trunk; in females, vulvar involvement is an additional risk factor.</p><p><strong>Conclusions: </strong>HS-SCC is rare but highly aggressive. Early recognition of high-risk phenotypes, regular monitoring of chronic HS lesions, timely surgery, and imaging assessment are essential to improve outcomes. HPV vaccination may offer preventive benefits in susceptible patients.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"331-341"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living in your own skin. The experience of the body in melanoma patients: a systematic literature review.","authors":"Isabella G Franzoi, Antonella Granieri, Maria D Sauta, Carola Grimaldi, Giulia Mirabile, Antonella Boglione, Monica Agnesone, Marco Gonella, Alessandro Comandone","doi":"10.23736/S2784-8671.26.08502-6","DOIUrl":"10.23736/S2784-8671.26.08502-6","url":null,"abstract":"<p><strong>Background: </strong>Melanoma can impair patients' physical, psychological, interpersonal, and economic balance. The effects of surgical interventions and the development of skin metastases might detrimentally impact on their body image, an embodied mental representation that shapes one's identity and interpersonal relationships.</p><p><strong>Methods: </strong>This systematic review investigates the perception of body image in melanoma patients and the relationship between body image and other psychosocial variables. The literature search identified nine eligible articles, which underwent data extraction and qualitative analysis. The results are organized into five categories: body image concerns; body image and social functioning; body image and cancer-related variables; body image and sociodemographic variables; body image and correlation with other psychosocial outcomes.</p><p><strong>Results: </strong>Despite the small number of eligible articles and the heterogeneity of emerging results, our review suggests that body image concerns are connected to other psychosocial problems such as quality of life and emotional distress and might be influenced by several tumor-related and demographic variables.</p><p><strong>Conclusions: </strong>Guided by progressive understanding of the specific facets of melanoma patients' suffering, multidisciplinary teams should design targeted psychological interventions to address patients' needs and improve their experience of the disease.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"350-358"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic fasciitis: a comprehensive systematic review of clinical, histologic, and therapeutic perspectives.","authors":"Giorgio Stabile, Nazario Pesce, Antonio Podo Brunetti, Irene Ignarra, Alberto Marini, Vanessa Bottino, Giorgia DI Marco, Carolina DE Rosa, Stefania Guida, Franco Rongioletti","doi":"10.23736/S2784-8671.26.08516-6","DOIUrl":"10.23736/S2784-8671.26.08516-6","url":null,"abstract":"<p><strong>Background: </strong>Eosinophilic fasciitis (EF) is a rare autoimmune disorder within the sclerodermatous disease spectrum, characterized by inflammation and fibrosis of the subcutaneous fat and fascia, often accompanied by peripheral eosinophilia. Although its exact etiology remains uncertain, potential triggers include intense physical exertion, infections, malignancies, and drug exposure - most recently, immune checkpoint inhibitors such as anti-PD-1/PD-L1 agents. Histopathological findings consistently reveal eosinophilic infiltration and fibrosis of subcutaneous fat and fascia. Corticosteroids remain the cornerstone of treatment, often supplemented with immunosuppressants in refractory cases. Emerging therapies, such as anti-IL-5 agents (mepolizumab and benralizumab), offer targeted approaches for corticosteroid-resistant EF by directly modulating eosinophilic inflammation.</p><p><strong>Methods: </strong>A systematic review of PubMed and Ovid was conducted according to PRISMA guidelines until October 2024, including studies on clinical, histological, or therapeutic aspects of eosinophilic fasciitis.</p><p><strong>Results: </strong>The mean age was 45.95 years, with balanced sex distribution (51.1% females). Most cases involved both upper and lower limbs (56.2%), followed by lower limbs (11.2%) and upper limbs alone (9.8%). Eosinophilia was present in 92.4% of patients, hypergammaglobulinemia in 19.9%, and elevated CRP in 13.5%. Histology showed eosinophilic infiltration in 68.9%. Identifiable triggers included intense exercise (8.7%), drugs - especially anti-PD1 checkpoint inhibitors (5.6%) - infections (2.8%), and paraneoplastic causes (2.3%). Treatments included corticosteroids (89.3%), methotrexate (27.5%), cyclosporine (6.7%), hydroxychloroquine (3.6%), azathioprine (3.9%), and rituximab (1.7%). Anti-IL5 agents (N.=7) were used in refractory cases, with full resolution in 2 and mild improvement in 5.</p><p><strong>Conclusions: </strong>This review provides a systematic analysis of the clinical, biological, and histological characteristics of EF, its associated triggers, and therapeutic strategies based on a comprehensive review of reported cases. We found that poor prognostic factors include diagnostic delay (>6 months), trunk involvement, early-onset disease (<12 years), and morphea-like skin lesions.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"319-330"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tocilizumab in melanoma: friend or foe?","authors":"Federica Scarfì, Michele Lanzetti, Antonia Gimma, Nerina Denaro, Franca Taviti","doi":"10.23736/S2784-8671.26.08578-6","DOIUrl":"10.23736/S2784-8671.26.08578-6","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"414-416"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When acne isn't acne: facial steatocystoma in a young adult.","authors":"Giulia Bazzacco, Irene D'Odorico, Veronica Lestani, Vanessa Mazzoletti, Giuseppe Stinco, Enzo Errichetti","doi":"10.23736/S2784-8671.26.08563-4","DOIUrl":"10.23736/S2784-8671.26.08563-4","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"413-414"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic epidermal necrolysis induced by lamotrigine with suspected venlafaxine-related relapse.","authors":"Silvia Borriello, Umberto Santaniello, Giovanni Cavaliere, Michela Ortoncelli, Nadia Sciamarrelli, Luca Mastorino, Luca Conti, Pietro Quaglino, Simone Ribero","doi":"10.23736/S2784-8671.26.08538-5","DOIUrl":"10.23736/S2784-8671.26.08538-5","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"408-410"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced nicotinamide-containing broad-spectrum sunscreen could prevent actinic keratosis relapse after lesion-directed or field-directed treatment: results of a nine-month follow-up-controlled study.","authors":"Francesco Lacarrubba, Anna E Verzì, Stefano Dimarco, Giuseppe Micali","doi":"10.23736/S2784-8671.26.08536-1","DOIUrl":"10.23736/S2784-8671.26.08536-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"407-408"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acral acanthotic anomaly: a comprehensive review.","authors":"Simona A Alomary, Meena M Hosny, Nabiha Sherali, Robert A Schwartz","doi":"10.23736/S2784-8671.26.08479-3","DOIUrl":"10.23736/S2784-8671.26.08479-3","url":null,"abstract":"<p><p>Acral acanthotic anomaly (AAA), also referred to as acral acanthosis nigricans (AAN), is a variant of acanthosis nigricans characterized by hyperpigmented, hyperkeratotic plaques localized to acral surfaces, particularly the knuckles, toes, and dorsal aspects of the hands and feet. Unlike other common forms, AAA is not typically associated with obesity, insulin resistance, or endocrinopathy. Its pathogenesis remains poorly understood. The aim of this article is to provide a comprehensive synthesis of the literature on AAA, including its epidemiology, clinical features, histopathologic findings, reported cases, and associated systemic associations. A narrative review of the literature was conducted using PubMed to identify articles discussing AAA. Relevant case reports and reviews were examined to extract data on presentation, histology, differential diagnosis, and potential clinical associations. Existing literature consistently describes a characteristic acral distribution and histologic features such as papillomatosis, hyperkeratosis, and basal pigmentation. Although often observed in otherwise healthy individuals, the literature demonstrates the potential for association with malignancy or autoimmune disease. Due to the rarity of AAA, available data are limited to case reports and small series, with no large-scale studies or longitudinal follow-up. Accurate recognition of AAA is essential to guide clinical evaluation, avoid unnecessary testing, and identify potential systemic associations when present.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"313-318"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}