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Italian Journal of Dermatology and Venereology最新文献

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Omalizumab: a broader role in dermatology? Evidence and the road ahead. Omalizumab：在皮肤病学中更广泛的作用？证据和前方的道路。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-05-08 DOI: 10.23736/S2784-8671.25.08144-7
Aditya K Bubna, Vinayak Viplav
{"title":"Omalizumab: a broader role in dermatology? Evidence and the road ahead.","authors":"Aditya K Bubna, Vinayak Viplav","doi":"10.23736/S2784-8671.25.08144-7","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08144-7","url":null,"abstract":"<p><p>Omalizumab is a humanized monoclonal IgG1 antibody approved by the US-FDA for the treatment of chronic spontaneous urticaria (CSU) unresponsive to H1-antihistamines. The aim of this review is to outline the utility of omalizumab in all types of urticarias, as well as other off-label dermatological disorders. A comprehensive literature search was conducted to identify studies evaluating the utility of omalizumab in dermatology. Databases searched included PubMed, Medline, and Embase. All original studies including case reports, case series and clinical trials were included if they were full-text, involved a dermatologic disorder treated with omalizumab and published in English. Articles were excluded if they were conference abstracts, non-clinical reports, or invitro studies. Apart from CSU, the efficacy of omalizumab has been demonstrated in atopic dermatitis (AD), bullous pemphigoid (BP), hyper IgE syndrome (HIES), mastocytosis, and Kimura's disease (KD), with the level of evidence varying for each disorder. Besides, in anecdotal reports, the benefits of omalizumab in TEN and Netherton Syndrome has been highlighted. Omalizumab offers a promising therapeutic option for a variety of dermatologic disorders beyond CSU. Further research is needed to optimize treatment protocols and establish definitive guidelines for omalizumab use in these conditions to facilitate quicker disease remission, improved safety, and reduced reliance on conventional immunosuppressants. However, the high cost of omalizumab remains a significant barrier for its widespread use in developing countries.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the treatment of male androgenetic alopecia: current options and emerging therapies. 男性雄激素性脱发的治疗进展：目前的选择和新兴的治疗方法。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-05-08 DOI: 10.23736/S2784-8671.25.08183-6
Aditya K Gupta, Mesbah Talukder, Shruthi Polla Ravi, Daniel Taylor, Tong Wang
{"title":"Advances in the treatment of male androgenetic alopecia: current options and emerging therapies.","authors":"Aditya K Gupta, Mesbah Talukder, Shruthi Polla Ravi, Daniel Taylor, Tong Wang","doi":"10.23736/S2784-8671.25.08183-6","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08183-6","url":null,"abstract":"<p><strong>Introduction: </strong>Androgenetic alopecia (AGA), or pattern hair loss, is the most common form of hair loss worldwide. It is primarily caused by genetic and hormonal factors, particularly the action of dihydrotestosterone (DHT) on hair follicles.</p><p><strong>Evidence acquisition: </strong>A comprehensive literature search on PubMed and Google Scholar was conducted until October 31, 2024, using keywords related to male AGA and its treatments. Relevant reviews, meta-analyses, clinical trials, and case studies in English were selected and analyzed to enhance the quality of the research. This review is based solely on existing studies and does not include new human or animal research conducted by the authors.</p><p><strong>Evidence synthesis: </strong>This review thoroughly examined and analyzed 149 articles to provide a detailed presentation of the evidence.</p><p><strong>Conclusions: </strong>This article examines both established and emerging therapies for AGA. We recommend initiating treatment with topical minoxidil and oral finasteride, as these are extensively researched and FDA-approved options for male AGA. For patients who do not respond well or cannot tolerate these treatments, clinicians may explore alternative therapies and approaches.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of vitiligo: a promising future. 白癜风的治疗：前景广阔。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-05-08 DOI: 10.23736/S2784-8671.25.08112-5
Jose L López-Estebaranz, Elena García-Zamora, Joseph S Griffiths-Acha
{"title":"Management of vitiligo: a promising future.","authors":"Jose L López-Estebaranz, Elena García-Zamora, Joseph S Griffiths-Acha","doi":"10.23736/S2784-8671.25.08112-5","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08112-5","url":null,"abstract":"<p><p>Vitiligo is an autoimmune disorder marked by progressive depigmentation due to the destruction of melanocytes. Affecting 0.5-1% of the global population, vitiligo significantly impacts patients' quality of life due to its visible and psychological burden. Current treatments, such as topical agents, phototherapy, and novel immunomodulatory therapies, aim to halt depigmentation and promote repigmentation, though many patients face challenges with relapse and inadequate treatment response. A comprehensive review of literature from dermatological and immunological studies was conducted, focusing on recent advancements in topical, systemic, and physical therapies for vitiligo. Both established and emerging treatments, such as Janus kinase (JAK) inhibitors, were examined. Topical corticosteroids (TCS), calcineurin inhibitors, and novel agents like ruxolitinib have shown efficacy in managing localized vitiligo, with oral JAK inhibitors emerging as promising treatments for more extensive disease. Phototherapy, particularly narrowband UVB (NB-UVB) and excimer light devices, remains the gold standard for repigmentation, often enhanced by combining topical agents. Surgical interventions, such as melanocyte transplants, offer additional options for refractory cases, while systemic immunosuppressants and biologics require further exploration. Advances in vitiligo treatment, particularly with targeted therapies like JAK inhibitors, offer new hope for patients. However, challenges remain in achieving sustained repigmentation and preventing relapse. Future research should focus on optimizing combination therapies and exploring novel biologic agents to improve long-term outcomes.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recalcitrant isotretinoin-induced acne fulminans successfully treated with oral dapsone. 口服氨苯砜成功治疗顽固性异维甲酸诱发的暴发性痤疮。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-04-28 DOI: 10.23736/S2784-8671.25.08200-3
Lorenzo Scaramuzzino, Luigi Coronella, Giuseppe Lauletta, Nello Tommasino, Fabrizio Martora, Laura Marano, Maria C Annunziata
{"title":"Recalcitrant isotretinoin-induced acne fulminans successfully treated with oral dapsone.","authors":"Lorenzo Scaramuzzino, Luigi Coronella, Giuseppe Lauletta, Nello Tommasino, Fabrizio Martora, Laura Marano, Maria C Annunziata","doi":"10.23736/S2784-8671.25.08200-3","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08200-3","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urticarial vasculitis induced by paroxetine: wood grain morphology. 帕罗西汀致荨麻疹血管炎：木纹形态学。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-04-22 DOI: 10.23736/S2784-8671.25.08155-1
Edoardo Cammarata, Astrid Lappi, Federica Sardanelli, Elia Esposto, Eleonora Folli, Paola Savoia
{"title":"Urticarial vasculitis induced by paroxetine: wood grain morphology.","authors":"Edoardo Cammarata, Astrid Lappi, Federica Sardanelli, Elia Esposto, Eleonora Folli, Paola Savoia","doi":"10.23736/S2784-8671.25.08155-1","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08155-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of perianal extramammary Paget disease from an erythematous patch to an achromic patch. 肛周乳腺外佩吉特病从红斑斑块到无色斑块的演变。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-04-22 DOI: 10.23736/S2784-8671.25.08052-1
Francesco Savoia, Matelda Medri, Isabella Banchelli, Marco A Chessa, Ignazio Stanganelli
{"title":"Evolution of perianal extramammary Paget disease from an erythematous patch to an achromic patch.","authors":"Francesco Savoia, Matelda Medri, Isabella Banchelli, Marco A Chessa, Ignazio Stanganelli","doi":"10.23736/S2784-8671.25.08052-1","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08052-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scabies with acral pustules mimicking infantile acropustulosis. 疥疮与肢端脓疱模仿婴儿肢端脓疱病。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-04-22 DOI: 10.23736/S2784-8671.25.08177-0
Luca Rapparini, Marco A Chessa, Iria Neri
{"title":"Scabies with acral pustules mimicking infantile acropustulosis.","authors":"Luca Rapparini, Marco A Chessa, Iria Neri","doi":"10.23736/S2784-8671.25.08177-0","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08177-0","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinic, dermoscopy and histology of Merkel cell carcinoma in a patient with a prior nodular melanoma on the ipsilateral limb. 默克尔细胞癌的临床，皮肤镜和组织学与既往结节性黑色素瘤患者的同侧肢体。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-04-22 DOI: 10.23736/S2784-8671.25.08268-4
Silvia Borriello, Umberto Santaniello, Matteo G Brizio, Paolo Fava, Rebecca Senetta, Francesco Cavallo, Orsola Crespi, Simone Ribero, Pietro Quaglino
{"title":"Clinic, dermoscopy and histology of Merkel cell carcinoma in a patient with a prior nodular melanoma on the ipsilateral limb.","authors":"Silvia Borriello, Umberto Santaniello, Matteo G Brizio, Paolo Fava, Rebecca Senetta, Francesco Cavallo, Orsola Crespi, Simone Ribero, Pietro Quaglino","doi":"10.23736/S2784-8671.25.08268-4","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08268-4","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hair and beyond: the experience of the Dermatology Department at the University of Rome La Sapienza. 头发及其他：罗马大学皮肤科的经验。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-04-10 DOI: 10.23736/S2784-8671.25.08172-1
Sandra Giustini, Alfredo Rossi, Luigina Divona, Emanuele Miraglia, Vincenzo Roberti, Roberto Porciello, Gemma Caro, Donato DI Nunno, Elisa Moliterni, Stefano Calvieri
{"title":"Hair and beyond: the experience of the Dermatology Department at the University of Rome La Sapienza.","authors":"Sandra Giustini, Alfredo Rossi, Luigina Divona, Emanuele Miraglia, Vincenzo Roberti, Roberto Porciello, Gemma Caro, Donato DI Nunno, Elisa Moliterni, Stefano Calvieri","doi":"10.23736/S2784-8671.25.08172-1","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08172-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding dermatological manifestations in carpal tunnel syndrome: a case series. 了解腕管综合征的皮肤病学表现：一个病例系列。
IF 1.8 4区 医学
Italian Journal of Dermatology and Venereology Pub Date : 2025-04-10 DOI: 10.23736/S2784-8671.25.08059-4
Michela V Starace, Stephano Cedirian, Alessio Natale, Federico Quadrelli, Yuri Merli, Giacomo Clarizio, Cosimo Misciali, Bianca M Piraccini
{"title":"Understanding dermatological manifestations in carpal tunnel syndrome: a case series.","authors":"Michela V Starace, Stephano Cedirian, Alessio Natale, Federico Quadrelli, Yuri Merli, Giacomo Clarizio, Cosimo Misciali, Bianca M Piraccini","doi":"10.23736/S2784-8671.25.08059-4","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08059-4","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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