Italian Journal of Dermatology and Venereology最新文献

{"title":"Bullous pemphigoid induced by linagliptin: a case series of 17 patients in a rare disease referral center.","authors":"Gaetano Licata, Luca Damiani, Graziella Babino, Paolino Franzese, Maria M Nicoletti, Giuseppe Argenziano, Caterina M Giorgio","doi":"10.23736/S2784-8671.25.08381-1","DOIUrl":"10.23736/S2784-8671.25.08381-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"176-177"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adalimumab treatment for scalp psoriasis after hair transplantation.","authors":"Graziella Babino","doi":"10.23736/S2784-8671.25.08369-0","DOIUrl":"10.23736/S2784-8671.25.08369-0","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"174-176"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile and scrotal eczema associated with enfortumab vedotin.","authors":"Davide Bertolla, Alba Guglielmo, Talita Mutton, Massimo Guidoboni, Alessandro Borghi","doi":"10.23736/S2784-8671.25.08420-8","DOIUrl":"10.23736/S2784-8671.25.08420-8","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"177-179"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive skin in patients with inflammatory chronic cutaneous disorders: results from an observational study on psoriasis, atopic dermatitis and hand eczema.","authors":"Alessandro Borghi, Fabrizio Guarneri, Lucrezia Pacetti, Leda Montesi, Monica Corazza","doi":"10.23736/S2784-8671.25.08299-4","DOIUrl":"10.23736/S2784-8671.25.08299-4","url":null,"abstract":"<p><strong>Background: </strong>Data on the prevalence of sensitive skin in patients with chronic inflammatory skin diseases are lacking. The aim of this study was to address this gap.</p><p><strong>Methods: </strong>This observational study included patients with psoriasis, atopic dermatitis or chronic hand eczema who attended the Unit of Dermatology of Ferrara and Messina, Italy, between June and December 2023. All participants completed a 10-item questionnaire for the diagnosis of sensitive skin (score range: 0-10). Participants were classified as having sensitive skin if they scored ≥4.</p><p><strong>Results: </strong>A total of 188 subjects were included, of whom 82 had psoriasis (mean Psoriasis Area and Severity Index [PASI] 4.2±5.1), 59 had atopic dermatitis (Eczema Area and Severity Index [EASI] 3.5±6.7) and 47 had hand eczema (Hand Eczema Severity Index [HECSI] 39.3±3.26). The mean questionnaire scores were 2.6±2.4 for psoriasis, 4.7±2.9 for atopic dermatitis, and 3.0±2.1 for hand eczema, with significant differences observed between atopic dermatitis and both psoriasis (P<0.001) and hand eczema (P<0.001). The prevalence of sensitive skin was higher among atopic dermatitis patients compared to those with psoriasis (P<0.001) and hand eczema (P<0.01).</p><p><strong>Conclusions: </strong>In the present study, which should be regarded as a pilot due to the relatively small number of cases included, sensitive skin was both more prevalent and more severe in patients with atopic dermatitis compared to those with psoriasis and hand eczema. Atopic dermatitis appears to promote skin sensitivity, independently of its clinical severity.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"161 2","pages":"97-103"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147529153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pink enigma: clinical and dermoscopic features of primary cutaneous PEComa.","authors":"Umberto Santaniello, Francesco Cavallo, Paolo Fava, Eleonora Bongiovanni, Rebecca Senetta, Paola Albini, Paolo Broganelli, Simone Ribero, Pietro Quaglino, Franco Picciotto","doi":"10.23736/S2784-8671.25.08449-X","DOIUrl":"10.23736/S2784-8671.25.08449-X","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"181-182"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards effective targeted therapies in morphea.","authors":"Amanda M Saracino, Laxmi Iyengar, Mandana Nikpour","doi":"10.23736/S2784-8671.25.08413-0","DOIUrl":"10.23736/S2784-8671.25.08413-0","url":null,"abstract":"<p><p>Morphea is a rare, clinically diverse inflammatory fibrosing skin condition presenting in children and adults. More severe subtypes of morphea can result in significant cosmetic and functional morbidity and warrant early systemic therapeutic intervention to minimize the risk of permanent tissue damage. Significant challenges exist in consensus classification and the development of robust validated measures of disease activity and damage. As a consequence, there are presently no approved therapies, and widely utilized consensus treatment guidelines are also lacking. At the core of the treatment challenge of morphea, is a limited understanding of disease immunopathogenic mechanisms. Pleasingly, some progress has been made in recent years, with advances in transcriptomic and immunologic profiling now defining morphea as a skin-directed, pro-inflammatory disorder which is likely a type 1 interferonopathy. Lesional skin demonstrates enrichment of type I interferon pathways, Th1 and Th17 cytokines, and B-cell activation, with growing evidence implicating keratinocyte-derived signaling in disease propagation. Accordingly, agents including Janus kinase (JAK) inhibitors, abatacept, and tocilizumab have shown some encouraging outcomes in small case series and observational studies, particularly in generalized, deep and/or treatment-resistant disease. Potential novel approaches targeting epidermal-dermal crosstalk, plasmacytoid dendritic cells, or fibroblast positional identity may offer future precision in treatment, but require expansion of our knowledge of molecular etiopathogenesis to be progressed. This narrative review aims to integrate current knowledge of clinical heterogeneity, molecular etiopathogenesis, and therapeutic clinical data to propose a forward-looking, mechanism-based framework for the clinical management of morphea.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"153-166"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deep learning model for histopathological diagnosis of actinic keratosis: a diagnostic case control accuracy study.","authors":"Julius Balkenhol, Max Schmidt, Tim Schnauder, Johannes Langhorst, Jean Le'clerc Arrastia, Daniel Otero Baguer, Georgia Gilbert, Francesco Lacarrubba, Thomas Dirschka, Lutz Schmitz","doi":"10.23736/S2784-8671.25.08336-7","DOIUrl":"10.23736/S2784-8671.25.08336-7","url":null,"abstract":"<p><strong>Background: </strong>Actinic keratosis (AK) is a precancerous skin lesion with the potential to progress into squamous cell carcinoma (SCC), with an overall prevalence of 14%. Although AK is not routinely biopsied, it represents a significant portion of dermatopathology cases. Advances in histopathology now allow for the digitization of slides using whole slide imaging (WSI). While deep learning models (DLMs) have shown promise in various medical fields, their application in dermatopathology remains limited.</p><p><strong>Methods: </strong>Building on prior research, we developed a U-Net-based DLM to detect AK in histopathological slides. A total of 371 cases were used to develop the DLM, with two optimal classification thresholds identified for different tasks.</p><p><strong>Results: </strong>In the test cohort, the DLM achieved an overall accuracy of 98.9% (98.7-99.1) at the patch level and an intersection over union (IoU) of 78.8%. At the WSI level, the DLM reached an accuracy of 96.8% (93.3-98.5) and an IoU of 67.7%. Additionally, 626 remaining cases were evaluated in a Diagnostic Case-Control-Accuracy Study, where the DLM's performance on AK slides and negative controls was compared to the gold standard, achieving an accuracy of 97.6% (96.4-98.5).</p><p><strong>Conclusions: </strong>Our findings demonstrate the potential of DLMs to reliably detect AK in routine dermatopathology, suggesting their future impact as technology continues to advance.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"161 2","pages":"104-114"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147529157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eruptive basal cell carcinomas of the scalp following local platelet-rich plasma injections: a coincidence or a possible trigger?","authors":"Enrico Bocchino, Daniele O Traini, Gerardo Palmisano, Marisa Salvi, Andrea Paradisi, Alessandro DI Stefani","doi":"10.23736/S2784-8671.25.08477-4","DOIUrl":"10.23736/S2784-8671.25.08477-4","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"184-185"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sporotrichoid leishmaniasis in psoriatic patient on biosimilar adalimumab therapy: an atypical clinical presentation.","authors":"Chiara Del Re, Vincenzo Filastro, Valeria Falcomatà, Pietro P Cozza, Antonella Tammaro","doi":"10.23736/S2784-8671.25.08254-4","DOIUrl":"10.23736/S2784-8671.25.08254-4","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"167-168"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxycycline postexposure prophylaxis: a cross-sectional survey on knowledge, attitudes and prescribing practices among Italian dermatologists of sexually transmitted infection centers.","authors":"Maria Gabriella Donà, Mauro Zaccarelli, Eugenia Giuliani, Claudia Colli, Laura Atzori, Valeria Gaspari, Stefano Ramoni, Luigi Pisano, Francesco Cariello, Antonio Pugliese, Giulia Ciccarese, Riccardo Balestri, Alessandra Latini","doi":"10.23736/S2784-8671.25.08346-X","DOIUrl":"10.23736/S2784-8671.25.08346-X","url":null,"abstract":"<p><strong>Background: </strong>Postexposure prophylaxis with doxycycline (Doxy-PEP) significantly reduces incidence of certain bacterial STIs in men who have sex with men (MSM) and individuals with recurrent STIs. We assessed knowledge, attitudes, and clinical experience regarding Doxy-PEP of dermatologists specialized in STI prevention, diagnosis, and treatment in Italy.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted in March 2025 using a questionnaire to investigate knowledge of Doxy-PEP prescribing protocols and patient eligibility, perceptions of its efficacy against several STIs, personal experience in Doxy-PEP prescription and drawbacks, opinions on its future use.</p><p><strong>Results: </strong>Thirty-six dermatologists participated. All knew about Doxy-PEP. The population most frequently considered eligible for Doxy-PEP was represented by MSM (69.4%). Respondents would prescribe Doxy-PEP after recent exposure (<72 hours) to chlamydia (58.3%), syphilis (50.0%), gonorrhea (25.0%), or multiple partnership (55.6%). Chemsex was indicated as the main risky behavior worth prescribing Doxy-PEP (69.4%). Approximately half of the respondents considered Doxy-PEP effective against chlamydia (47.2%), whereas only 14.3% and 2.8% were convinced of its efficacy against syphilis and gonorrhea, respectively. Only 19.4% of the respondents had prescribed Doxy-PEP, with no adverse events reported. Doxy-PEP failure was observed by 36.1% of the dermatologists. The main concerns included Neisseria gonorrhoeae resistance (91.7%), methicillin-resistant Staphylococcus aureus (MRSA) selection (91.7%), and microbiota alterations (86.1%). A progressive increase in Doxy-PEP use is anticipated, driven by patient demand, community influences, and international guidelines.</p><p><strong>Conclusions: </strong>Dermatologists of Italian STI centers demonstrate appropriate awareness of Doxy-PEP but maintain cautious attitudes toward efficacy and show a substantial concern about antibiotic resistance.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"161 2","pages":"120-125"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147529141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}