Italian Journal of Dermatology and Venereology最新文献

{"title":"Rodent models of dermatological disorders.","authors":"Dorottya Asbóth, Barnabás Bánfi, Dorottya Kocsis, Franciska Erdő","doi":"10.23736/S2784-8671.23.07700-9","DOIUrl":"10.23736/S2784-8671.23.07700-9","url":null,"abstract":"<p><p>To assess the possible beneficial effects of drugs and drug candidates, different dermatological disease models are available in rodents. These models are able to mimic one or more characteristic features of the disorders, but not completely recapitulate the pathogenesis of the human skin diseases. Therefore, to improve the technology many new models have been developed both by genetic engineering and by chemical or physical induction. Currently the in vivo rodent models provide the physiologically most relevant approach to produce the pathology related to the majority of dermatological diseases. In this short review some widely used animal techniques (psoriasis, allergic contact dermatitis, atopic dermatitis, wound healing, melanoma and non-melanoma type skin cancers and UV erythema) are shown which are currently applied in pharmacological, pharmacokinetic, pharmaceutical and dermatological research. First the main points of the human pathomechanism are shown and afterwards the rodent models are briefly discussed. Finally critical evaluation is provided by the authors. However, according to the 3R rule the number of experimental animals is strongly suggested to be reduced, therefore the advanced in vitro and ex vivo techniques become more and more important contrary to in vivo preclinical methods also in dermatological research. As it is described in the outlook section, although the 2D/3D in vitro and skin on-a-chip techniques are promising and have many advantages they are not able to completely substitute the animal models in their vascular, immunological, secretory and neural complexity.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"303-317"},"PeriodicalIF":1.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Italian S3-Guideline on the treatment of Atopic Eczema - Part 2: non-systemic treatments and treatment recommendations for special AE patient populations, adapted from EuroGuiDerm by the Italian Society of Dermatology and STD (SIDEMAST), the Italian Association of Hospital Dermatologists (ADOI) and the Italian Society of Allergological and Occupational Dermatology (SIDAPA).","authors":"Giuseppe Argenziano, Francesco Cusano, Monica Corazza, Salvatore Amato, Paolo Amerio, Luigi Naldi, Cataldo Patruno, Paolo D Pigatto, Pietro Quaglino, Paolo Gisondi, Andrea Chiricozzi, Francesco Tonon, Luca Stingeni, Piergiacomo Calzavara-Pinton, Andreas Wollenberg, Maria Kinberger, Bernd W Arents, Nora Aszodi, Gabriela L Avila Valle, Sebastien Barbarot, Thomas Bieber, Helen A Brough, Stéphanie Christen-Zäch, Mette Deleuran, Martin Dittmann, Corinna Dressler, Antjie H Fink-Wagner, Nicole Fosse, Krisztián Gáspár, Louise A Gerbens, Uwe Gieler, Giampiero Girolomoni, Stamatios Gregoriou, Charlotte G Mortz, Alexander Nast, Uffe Nygaard, Magali Redding, Eva M Rehbinder, Johannes Ring, Mariateresa Rossi, Esther Serra-Baldrich, Dagmar Simon, Zsuzsanna Z Szala I, Jacek C Szepietowski, Antonio Torrelo, Thomas Werfel, Carsten Flohr","doi":"10.23736/S2784-8671.24.07666-7","DOIUrl":"10.23736/S2784-8671.24.07666-7","url":null,"abstract":"<p><p>SIDeMaST (Società Italiana di Dermatologia Medica, Chirurgica, Estetica e delle Malattie Sessualmente Trasmesse) contributed to the development of the present guideline on the systemic treatment of chronic plaque psoriasis. With the permission of EuroGuiDerm, SIDeMaST adapted the guideline to the Italian healthcare context to supply a reliable and affordable tool to Italian physicians who take care of patients affected by atopic dermatitis. The evidence- and consensus-based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. Four consensus conferences were held between December 2020 and July 2021. Twenty-nine experts (including clinicians and patient representatives) from 12 European countries participated. This second part of the guideline includes recommendations and detailed information on basic therapy with emollients and moisturizers, topical anti-inflammatory treatment, antimicrobial and antipruritic treatment and UV phototherapy. Furthermore, this part of the guideline covers techniques for avoiding provocation factors, as well as dietary interventions, immunotherapy, complementary medicine and educational interventions for patients with atopic eczema and deals with occupational and psychodermatological aspects of the disease. It also contains guidance on treatment for pediatric and adolescent patients and pregnant or breastfeeding women, as well as considerations for patients who want to have a child. A chapter on the patient perspective is also provided. The first part of the guideline, published separately, contains recommendations and guidance on systemic treatment with conventional immunosuppressive drugs, biologics and janus kinase (JAK) inhibitors, as well as information on the scope and purpose of the guideline, and a section on guideline methodology.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"251-278"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary to the publication of the Italian adaptation of the EuroGuiDerm guidelines for Atopic Dermatitis.","authors":"Piergiacomo Calzavara-Pinton, Francesco Tonon, Mariateresa Rossi","doi":"10.23736/S2784-8671.24.07669-2","DOIUrl":"10.23736/S2784-8671.24.07669-2","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"219-222"},"PeriodicalIF":1.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A proposed protocol for UVBnb phototherapy in a patient with severe AD and mild PSO treated with dupilumab.","authors":"Vittoria Cioppa, Laura Lazzeri, Francesca Falcinelli, Pietro Rubegni, Filomena Russo","doi":"10.23736/S2784-8671.23.07687-9","DOIUrl":"10.23736/S2784-8671.23.07687-9","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"358-360"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disappearance of chrysalis structures: a potential sign to differentiate tumoral melanosis from cutaneous melanoma metastases.","authors":"Vanessa Mazzoletti, Francesco Cavallo, Enrico Zelin, Giulia Bazzacco, Filippo Chersi, Alberto Zacchi, Nicola DI Meo, Iris Zalaudek","doi":"10.23736/S2784-8671.24.07847-2","DOIUrl":"10.23736/S2784-8671.24.07847-2","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"371-373"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Italian S3-Guideline on the treatment of Atopic Eczema - First Update, adapted from EuroGuiDerm by the Italian Society of Dermatology and STD (SIDEMAST), the Italian Association of Hospital Dermatologists (ADOI) and the Italian Society of Allergological and Occupational Dermatology (SIDAPA).","authors":"Giuseppe Argenziano, Francesco Cusano, Monica Corazza, Salvatore Amato, Paolo Amerio, Luigi Naldi, Cataldo Patruno, Paolo D Pigatto, Pietro Quaglino, Paolo Gisondi, Andrea Chiricozzi, Francesco Tonon, Luca Stingeni, Piergiacomo Calzavara-Pinton, Andreas Wollenberg, Maria Kinberger, Bernd W Arents, Nora Aszodi, Gabriela L Avila Valle, Sebastien Barbarot, Thomas Bieber, Helen A Brough, Stéphanie Christen-Zäch, Mette Deleuran, Martin Dittmann, Corinna Dressler, Antjie H Fink-Wagner, Nicole Fosse, Krisztián Gáspár, Louise A Gerbens, Uwe Gieler, Giampiero Girolomoni, Stamatios Gregoriou, Charlotte G Mortz, Alexander Nast, Uffe Nygaard, Magali Redding, Eva M Rehbinder, Johannes Ring, Mariateresa Rossi, Esther Serra-Baldrich, Dagmar Simon, Zsuzsanna Z Szala I, Jacek C Szepietowski, Antonio Torrelo, Thomas Werfel, Carsten Flohr","doi":"10.23736/S2784-8671.24.07667-9","DOIUrl":"10.23736/S2784-8671.24.07667-9","url":null,"abstract":"<p><p>The evidence- and consensus-based guideline on atopic eczema, published in JEADV on 18 August 2022 (part 1) and 3 September 2022 (part 2) was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. Four consensus conferences were held between December 2020 and July 2021. Twenty-nine experts (including clinicians and patient representatives) from 12 European countries participated. To reflect the most recent evidence on novel systemic medications, an update was published in October 2022. According to the purpose of the Italian Society of Dermatology and STD (SIDEMAST), the Italian Association of Hospital Dermatologists (ADOI) and the Italian Society of Allergological and Environmental Dermatology (SIDAPA) to adapt the EuroGuiDerm guideline on the treatment of atopic eczema into the Italian Healthcare setting, the original update has been supplemented by inserting notes, well highlighted by the original text, to emphasize the laws, rules, procedures and suggestions of the Italian Ministry of Health and regional Health authorities.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"279-284"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of secukinumab in pediatric patients: description of a case of annular psoriasis followed since neonatal age.","authors":"Nicolò DI Giuli, Alice Moiraghi, Martina Volonté, Emanuele M Favale, Alice Bonelli, Amelia Licari, Valeria Brazzelli","doi":"10.23736/S2784-8671.24.07783-1","DOIUrl":"10.23736/S2784-8671.24.07783-1","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"159 3","pages":"363-364"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of tissue culture in ecthyma gangrenosum: multidrug-resistant Pseudomonas aeuruginosa vulvar ecthyma gangrenosum.","authors":"Lula M Nieto-Benito","doi":"10.23736/S2784-8671.24.07842-3","DOIUrl":"10.23736/S2784-8671.24.07842-3","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"368-370"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dramatic progression of multifocal primary cutaneous anaplastic large-cell lymphoma.","authors":"Gianluca Avallone, Francesco Leo, Chiara Astrua, Luca Mastorino, Renato Parente, Marcella Grassi, Renato Fabrizio, Andrea Ferraris, Pietro Quaglino, Simone Ribero","doi":"10.23736/S2784-8671.24.07852-6","DOIUrl":"10.23736/S2784-8671.24.07852-6","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"215-216"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis: a new adverse event of ibrutinib.","authors":"Luca Rapparini, Alice Massi, Carlotta Baraldi, Gabriele Gugliotta, Alessandro Pileri","doi":"10.23736/S2784-8671.23.07735-6","DOIUrl":"10.23736/S2784-8671.23.07735-6","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"205-207"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}