Martina Burlando, Barbara Piazza, Antonio Guadagno, Emanuele Cozzani
{"title":"Eczematous eruption after ixekizumab successfully treated with upadacitinib.","authors":"Martina Burlando, Barbara Piazza, Antonio Guadagno, Emanuele Cozzani","doi":"10.23736/S2784-8671.24.08050-2","DOIUrl":"https://doi.org/10.23736/S2784-8671.24.08050-2","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 1","pages":"81-82"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Briatico, Gaetano Licata, Vittorio Tancredi, Carmine Fiorentino, Camila Scharf, Francesca Pagliuca, Giuseppe Argenziano, Caterina M Giorgio
{"title":"Intralesional rifampicin for cutaneous leishmaniosis: a case report with reflectance confocal microscopy therapy assessment.","authors":"Giulia Briatico, Gaetano Licata, Vittorio Tancredi, Carmine Fiorentino, Camila Scharf, Francesca Pagliuca, Giuseppe Argenziano, Caterina M Giorgio","doi":"10.23736/S2784-8671.24.07967-2","DOIUrl":"10.23736/S2784-8671.24.07967-2","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"67-68"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimates of the burden of skin melanoma in Italy: update to 2024.","authors":"Emanuele Crocetti, Federica Zamagni, Fabio Falcini, Rosa Vattiato, Flavia Baldacchini, Chiara Balducci, Orietta Giuliani, Silvia Mancini, Alessandra Ravaioli, Benedetta Vitali, Lauro Bucchi","doi":"10.23736/S2784-8671.24.08033-2","DOIUrl":"10.23736/S2784-8671.24.08033-2","url":null,"abstract":"<p><strong>Background: </strong>The epidemiology of skin melanoma (SM) is rapidly changing. Therefore, we aimed at updating up to 2024 the Italian estimates on SM providing the number of incident and prevalent cases, the deaths and the distribution by stage at diagnosis.</p><p><strong>Methods: </strong>Incidence was extrapolated from age- and sex-specific International Agency for Research on Cancer (IARC) estimates from 2022 to 2025. For mortality, we applied to the most recent observed deaths, the average sex- and age-specific annual percent change estimated by the IARC from 2022 to 2025. Regarding SM prevalence, we assumed the age- and sex-specific annual change in the number of prevalent cases observed from 2010 to 2020 to be stable until 2024. Finally, we applied the average distribution by TNM-8 stages of four population-based SM series to provide a possible stage distribution at diagnosis.</p><p><strong>Results: </strong>We estimated almost 13,800 newly diagnosed SMs (54% men and 82% people older than 44 years), 2240 deaths (60% men and 49% people older than 74 years) and about 216,000 prevalent cases (51% women). At diagnosis, around 10,240 cases are expected to be stage I, 2120 stage II, 1100 stage III and 327 stage IV. As regards stage I 79% will be IA. Among stage II we expect 44% IIA, 33% IIB and 22% IIC. Among stage III, 49% case are expected to be IIIC.</p><p><strong>Conclusions: </strong>These estimates allow clinicians and policymakers to quantify and properly address the burden of SM patients' diagnostic, therapeutic and supportive needs.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"1-6"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Bassi, Michela Magnano, Cesare Filippeschi, Samantha Berti, Laura Bachini, Martina Vispi, Camilla Peccianti, Giordana Coronella, Teresa Oranges, Carlo Mazzatenta
{"title":"Tuscany consensus for pediatric scabies: update on clinical management and the urgent need for new guidelines.","authors":"Andrea Bassi, Michela Magnano, Cesare Filippeschi, Samantha Berti, Laura Bachini, Martina Vispi, Camilla Peccianti, Giordana Coronella, Teresa Oranges, Carlo Mazzatenta","doi":"10.23736/S2784-8671.24.07991-X","DOIUrl":"10.23736/S2784-8671.24.07991-X","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess the degree of agreement among pediatric dermatologists in Tuscany concerning different aspects of scabies infestation management in children, employing the Delphi method.</p><p><strong>Methods: </strong>We conducted a Delphi study involving ten pediatric dermatology centers in Tuscany, Italy. Questionnaires were distributed to a panel of experts anonymously. The questionnaires were organized into six specific topics: \"diagnosis,\" \"hygiene measures,\" \"application of topical products,\" \"treatment,\" \"treatment of exposed individuals,\" and \"clinical follow-up after therapy.\" Each question within these topics offered six different response options.</p><p><strong>Results: </strong>All participating dermatologists completed the two-round questionnaire. Full consensus was reached for all statements related to \"diagnosis,\" \"hygiene measures,\" \"treatment of exposed individuals,\" \"application of topical products,\" and \"clinical follow-up after therapy,\" since each statement met the predetermined consensus threshold of 70% or higher. However, we could not achieve a substantial consensus on the treatment of scabies, aside from agreement on the lower efficacy of permethrin therapy.</p><p><strong>Conclusions: </strong>Considering the growing recognition of Sarcoptes scabiei resistance to conventional permethrin therapy, this regional consensus offers clear insights into the overall management of scabies. However, it also reveals that each dermatologist primarily relies on their own experiences for medical treatment, which may not be universally shared among colleagues. This emphasizes the urgent necessity for updated guidelines on therapeutic strategies.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"12-19"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Angioedema-like allergic contact dermatitis in a pediatric patient due to an eyebrows dye.","authors":"Lorenzo Melloni, Federico Gianessi, Chiara Bocchi, Elisa Marzola, Alessandro Borghi, Monica Corazza","doi":"10.23736/S2784-8671.24.07977-5","DOIUrl":"10.23736/S2784-8671.24.07977-5","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"69"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria E Greco, Simone Michelini, Emanuele Amore, Antonio DI Guardo, Vito V Gomes, Luca Guarino, Francesca P Sasso, Federica Trovato, Giovanni Pellacani
{"title":"Nummular eczema following brigatinib administration in patient with lung cancer.","authors":"Maria E Greco, Simone Michelini, Emanuele Amore, Antonio DI Guardo, Vito V Gomes, Luca Guarino, Francesca P Sasso, Federica Trovato, Giovanni Pellacani","doi":"10.23736/S2784-8671.24.08002-2","DOIUrl":"10.23736/S2784-8671.24.08002-2","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"72-74"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alfredo Martinez-Gutierrez, Javier Sendros, Teresa Noya, Mari C González
{"title":"Novel transethosome coencapsulated combination for acne treatment: in-vitro efficacy and ex-vivo biodistribution studies.","authors":"Alfredo Martinez-Gutierrez, Javier Sendros, Teresa Noya, Mari C González","doi":"10.23736/S2784-8671.24.07982-9","DOIUrl":"https://doi.org/10.23736/S2784-8671.24.07982-9","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris is a skin condition affecting approximately 85% of young adults. It is influenced by androgens and primarily occurs in the pilosebaceous unit, where inflammation and obstruction happen. Hyperseborrhea and hyperkeratinization lead to increased levels of fatty acids and necrotic keratinocytes, promoting the proliferation of C. acnes phylotype IA1.</p><p><strong>Methods: </strong>Here, the in-vitro efficacy of a novel combination on the main processes involved in acne was studied. Furthermore, the combination was coencapsulated in transethosomes to target the pilosebaceous unit, and the biodistribution was analyzed ex vivo by fluorescence microscopy.</p><p><strong>Results: </strong>The combination of compounds reduced inflammatory markers levels, sebum production and 5α-Reductase levels while it induced autophagy and FOXO1 nuclear levels in sebocytes. The compounds coencapsulated in transethosomes reached the pilosebaceous unit as proven by the ex vivo analysis.</p><p><strong>Conclusions: </strong>The proposed combination of compounds is a promising approach to be included in topical products for the treatment of acne vulgaris.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 1","pages":"7-11"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Bazzacco, Filippo Chersi, Enrico Zelin, Vanessa Mazzoletti, Nicola DI Meo, Iris Zalaudek, Raffaele D Caposiena Caro
{"title":"New onset vitiligo induced by dupilumab therapy for severe asthma: a case report and a short review of the literature.","authors":"Giulia Bazzacco, Filippo Chersi, Enrico Zelin, Vanessa Mazzoletti, Nicola DI Meo, Iris Zalaudek, Raffaele D Caposiena Caro","doi":"10.23736/S2784-8671.24.07987-8","DOIUrl":"10.23736/S2784-8671.24.07987-8","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"71-72"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}