Iranian Journal of Medical Sciences最新文献

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Mesenteric Panniculitis: An Enigma. 肠系膜泛发炎:一个谜。
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-03-01 DOI: 10.30476/IJMS.2023.98397.3074
Amit Kumar Gupta, Niraj Shrivastava
{"title":"Mesenteric Panniculitis: An Enigma.","authors":"Amit Kumar Gupta, Niraj Shrivastava","doi":"10.30476/IJMS.2023.98397.3074","DOIUrl":"https://doi.org/10.30476/IJMS.2023.98397.3074","url":null,"abstract":"","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 3","pages":"201-203"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of High-intensity Laser Therapy with Extracorporeal Shock Wave Therapy in the Treatment of Patients with Plantar Fasciitis: A Double-blind Randomized Clinical Trial. 高强度激光疗法与体外冲击波疗法在治疗足底筋膜炎患者方面的比较:双盲随机临床试验。
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-03-01 DOI: 10.30476/IJMS.2023.98042.2991
Marzieh Zare Bidoki, Mohammad Reza Vafaeei Nasab, Amidodin Khatibi Aghda
{"title":"Comparison of High-intensity Laser Therapy with Extracorporeal Shock Wave Therapy in the Treatment of Patients with Plantar Fasciitis: A Double-blind Randomized Clinical Trial.","authors":"Marzieh Zare Bidoki, Mohammad Reza Vafaeei Nasab, Amidodin Khatibi Aghda","doi":"10.30476/IJMS.2023.98042.2991","DOIUrl":"https://doi.org/10.30476/IJMS.2023.98042.2991","url":null,"abstract":"<p><strong>Background: </strong>The most common cause of heel pain is plantar fasciitis (PF). Although conservative treatments relieve pain in more than 90% of patients, it may remain painful in some cases. This study aimed to compare High-intensity Laser Therapy (HILT) with Extracorporeal Shock Wave Therapy (ESWT) in patients with PF.</p><p><strong>Methods: </strong>In this double-blinded randomized clinical trial (conducted in Yazd, Iran, from May 2020 to March 2021), patients were classified into two groups, including the ESWT and HILT, using online randomization. Nine sessions, three times a week for 3 weeks, were the treatment period in both groups. Visual Analogue Score (VAS), Heel Tenderness Index (HTI), and the SF36 questionnaire were compared and analyzed statistically at the beginning and 9 months after treatment.</p><p><strong>Results: </strong>38 patients (19 in each group) completed the study. Results showed that pain and patient satisfaction improved significantly 3 months after treatment. The VAS and HTI decreased 3 months after treatment in both groups, which was statistically significant (P<0.001). The SF36 score in both groups increased 3 months after treatment, and this increase was statistically significant (P<0.001). Although the two modalities were effective based on VAS, HTI, and SF36, a significant statistical difference was observed between them (P=0.03, P=0.006, P=0.002, respectively), and the HILT was more effective.</p><p><strong>Conclusion: </strong>ESWT and HILT decrease pain and increase patient satisfaction in PF. Besides, both methods are non-invasive and safe. However, there is a significant difference between them, and HILT is more effective. <b>Trial registration number:</b> IRCT20210913052465N1.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 3","pages":"147-155"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Fish-Based Diet on Malnourished Children: A Systematic Review. 鱼类膳食对营养不良儿童的影响:系统回顾。
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-03-01 DOI: 10.30476/ijms.2023.96986.2863
La Banudi La Banudi, Purnomo Leksono, M Anas Anasiru
{"title":"Effect of Fish-Based Diet on Malnourished Children: A Systematic Review.","authors":"La Banudi La Banudi, Purnomo Leksono, M Anas Anasiru","doi":"10.30476/ijms.2023.96986.2863","DOIUrl":"https://doi.org/10.30476/ijms.2023.96986.2863","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition in children is mainly caused by the lack of protein and fat intake which harms their ability to grow and survive. Accurate data on the benefits of fish-based foods on the nutritional status of children is limited. The present systematic review aimed to provide an overview of published articles on the nutritional value of fish-based foods for children.</p><p><strong>Methods: </strong>A systematic review was performed during 2000-2021 by searching Science Direct, Cochrane Library, PubMed, ProQuest, and Wiley Online Library databases. The full text of selected articles in English was screened based on the inclusion and exclusion criteria. Included articles were all experimental studies (randomized control trial, quasi-randomized trial) or mixed methods studies involving malnourished children. The study was reported under the preferred reporting items for systematic reviews and meta-analyses guidelines. The risk of bias was assessed using the Cochrane tool.</p><p><strong>Results: </strong>A total of 330,859 articles were screened, out of which eight articles were included in the systematic review. Interventions included fish-based foods and beverages such as wafer bars, Jemawut-tuna cookies, Amizate in chocolate drink, dried fish powder, flaxseed oil supplemented with fish oil capsules, and porridge fortified with fish powder. Primary or secondary outcomes were the determination of zinc level, height growth, erythrocyte n-3 polyunsaturated fatty acid content, safety and acceptability, intestinal integrity, and cognitive development. The results showed that dried fish powder produced the most significant effect on body weight.</p><p><strong>Conclusion: </strong>The consumption of dried fish powder had positive effects on the recovery of malnourished children.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 3","pages":"137-146"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of US-7 and US-9 Scores with Disease Activity Score using 28 Joint Counts (DAS28) in Patients with Rheumatoid Arthritis. 类风湿关节炎患者 US-7 和 US-9 评分与使用 28 个关节计数的疾病活动度评分 (DAS28) 的相关性。
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-03-01 DOI: 10.30476/IJMS.2023.97776.2996
Sahar Ebadati, Maryam Sahebari, Amir Mahmoud Ahmadzadeh, Maryam Emadzadeh, Farzaneh Khoroushi, Hedieh Ragati Haghi, Ramesh Giti, Behzad Aminzadeh
{"title":"Correlation of US-7 and US-9 Scores with Disease Activity Score using 28 Joint Counts (DAS28) in Patients with Rheumatoid Arthritis.","authors":"Sahar Ebadati, Maryam Sahebari, Amir Mahmoud Ahmadzadeh, Maryam Emadzadeh, Farzaneh Khoroushi, Hedieh Ragati Haghi, Ramesh Giti, Behzad Aminzadeh","doi":"10.30476/IJMS.2023.97776.2996","DOIUrl":"https://doi.org/10.30476/IJMS.2023.97776.2996","url":null,"abstract":"<p><strong>Background: </strong>The attentive management of rheumatoid arthritis (RA) has attracted particular attention. The German 7-joint Ultrasound (US-7) is the first scoring system that combines bone erosions and soft tissue lesions in a single composite scoring system. This study aimed to assess the correlation between US-7 and Disease Activity Score Using 28 Joint Counts (DAS28) in clinically active RA patients. The efficacy of a novel ultrasound score-based system, the US-9 score (joints assessed with US-7 plus knees), was also compared with the standard US-7 score.</p><p><strong>Methods: </strong>All the RA patients referred to the outpatient rheumatology clinic of Ghaem Hospital, Mashhad, Iran, during 2019-2020 were included. 28 joints were clinically examined to calculate DAS28. Nine joints were assessed comprising the German US-7 plus knees using grayscale ultrasonography (GSUS) and power Doppler ultrasonography (PDUS). Retrieved data were analyzed by SPSS software, version 22. The Spearman Correlation test was used to find the correlation between DAS28 and ultrasonographic findings. The statistical significance level was set at P<0.05.</p><p><strong>Results: </strong>This study was composed of thirty-five RA patients with a mean age of 49.1±12.0 years. US-7 synovitis scores in GSUS and PDUS were significantly correlated with DAS28 (P=0.02, r=0.38 and P=0.003, r=0.48, respectively). US-9 synovitis scores in GSUS and PDUS were also significantly correlated with DAS28 (P=0.003, r=0.49 and P=0.006, r=0.45, respectively). The synovitis score measured by GSUS was significantly correlated with the GSUS knee synovial score (P=0.01, r=0.42).</p><p><strong>Conclusion: </strong>Ultrasound assessment of large joints such as knees can be an effective approach to determining RA severity. However, it can be proposed that adding more involved joints into the sonographic assessment does not necessarily provide a better clinical correlation.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 3","pages":"167-175"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose-Derived Stem Cells' Secretome Attenuates Lesion Size and Parasite Loading in Leishmaniasis Caused by Leishmania Major in Mice. 脂肪干细胞的分泌物减轻小鼠利什曼病的皮损面积和寄生虫负荷
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.96413.2795
Iman Khodkar, Jasem Saki, Reza Arjmand, Ghasem Saki, Layasadat Khorsandi
{"title":"Adipose-Derived Stem Cells' Secretome Attenuates Lesion Size and Parasite Loading in Leishmaniasis Caused by <i>Leishmania Major</i> in Mice.","authors":"Iman Khodkar, Jasem Saki, Reza Arjmand, Ghasem Saki, Layasadat Khorsandi","doi":"10.30476/IJMS.2023.96413.2795","DOIUrl":"10.30476/IJMS.2023.96413.2795","url":null,"abstract":"<p><strong>Background: </strong>Stem cell-derived secretome (SE) released into the extracellular space contributes to tissue repair. The present study aimed to investigate the impact of isolated secretome (SE) from adipose-derived mesenchymal stem cells (ASCs) on <i>Leishmania major</i> (<i>L. major</i>) lesions in BALB/c mice.</p><p><strong>Methods: </strong>This experimental study was conducted at Ahvaz University of Medical Sciences (Ahvaz, Iran) in 2021. Forty female BALB/c mice were infected with stationary phase promastigotes through intradermal injection in the bottom of their tail and randomly divided into four groups (n=10 per group). The mice were given SE (20 mg/mL), either alone or in combination with Glucantime (GC, 20 mg/mL/Kg), meglumine antimoniate (20 mg/mL/Kg) for the GC group, and phosphate-buffered saline (PBS) for the control group. After eight weeks, the lesion size, histopathology, the levels of Interleukin 10 (IL-10), and Interleukin 12 (IL-12) were assessed. For the comparison of values between groups, the parametric one-way ANOVA was used to assess statistical significance.</p><p><strong>Results: </strong>At the end of the experiment, the mice that received SE had smaller lesions (4.56±0.83 mm versus 3.62±0.59 mm, P=0.092), lower levels of IL-10 (66.5±9.7 pg/mL versus 285.4±25.2 pg/mL, P<0.001), and higher levels of IL-12 (152.2±14.2 pg/mL versus 24.2±4.4 pg/mL, P<0.001) than the control. Histopathology findings revealed that mice treated with SE had a lower parasite burden in lesions and spleen than the control group.</p><p><strong>Conclusion: </strong>The current study demonstrated that ADSC-derived SE could protect mice infected with <i>L. major</i> against leishmaniasis.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 2","pages":"121-129"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Telogen Effluvium Incidence in Hospitalized and Outpatient Settings after Recovery from COVID-19. COVID-19康复后住院患者和门诊患者毛发脱落症发病率的比较。
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.98516.3053
Ali Asilian, Fariba Iraji, Sayed Mohsen Hosseini, Parisa Mohammadian Dehkordi
{"title":"Comparison of Telogen Effluvium Incidence in Hospitalized and Outpatient Settings after Recovery from COVID-19.","authors":"Ali Asilian, Fariba Iraji, Sayed Mohsen Hosseini, Parisa Mohammadian Dehkordi","doi":"10.30476/IJMS.2023.98516.3053","DOIUrl":"10.30476/IJMS.2023.98516.3053","url":null,"abstract":"","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 2","pages":"134-136"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation Between Intimate Partner Violence During Pregnancy and Parental Acceptance by Primiparous Mothers. 孕期亲密伴侣暴力与初产母亲对父母的接受度之间的相关性。
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.97325.2903
Masomah Jalili, Shahnaz Kohan, Mohammad Javad Tarrahi, Fatemeh Torabi
{"title":"Correlation Between Intimate Partner Violence During Pregnancy and Parental Acceptance by Primiparous Mothers.","authors":"Masomah Jalili, Shahnaz Kohan, Mohammad Javad Tarrahi, Fatemeh Torabi","doi":"10.30476/IJMS.2023.97325.2903","DOIUrl":"10.30476/IJMS.2023.97325.2903","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy and the transition to parenthood are periods in parents' lives that require tremendous adjustment. The physical and mental health of mothers during these periods is significantly associated with maternal acceptance. The present study aimed to evaluate the correlation between intimate partner violence (IPV) during pregnancy and parental acceptance by primiparous mothers in Isfahan, Iran.</p><p><strong>Methods: </strong>A cross-sectional descriptive and correlational study was conducted from September 2021 to February 2022 in Isfahan, Iran. The target population was primiparous mothers in the postpartum period referred to nine different health centers across Isfahan. The participants (n=308) completed three questionnaires, namely demographic, Tabrizi intimate partner violence screening, and parental acceptance questionnaire. Data were analyzed using descriptive and inferential statistics with SPSS software (version 22.0). P<0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean score of total IPV was 40.45±28.94. Domestic violence during pregnancy was reported by 59 (19.2%) mothers. The most common types were psychological violence (74.4%), followed by financial abuse (35.1%), sexual violence (17.2%), and physical violence (14.9%). The mean score of parental acceptance was 115.77±12.58. There was a significant inverse correlation between parental acceptance and IPV score (r=-0.15, P=0.005). The number of siblings and birth order had a significant inverse correlation with parental acceptance (r=-0.13, P=0.002; r=-0.13, P=0.002, respectively). Moreover, the age difference between the mothers and their next siblings had a significant direct correlation with parental acceptance (r=0.12, P=0.003).</p><p><strong>Conclusion: </strong>Primiparous mothers subjected to IPV during pregnancy had lower parental acceptance after delivery.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 2","pages":"101-109"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Sealing of Post-COVID-19 Bronchopleural Fistula with Computed Tomography Scan-Guided Percutaneous Cyanoacrylate Glue Injection: A Case Series. 计算机断层扫描引导下经皮氰基丙烯酸酯胶注射成功封堵 COVID-19 后支气管胸膜瘘:病例系列。
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.97068.2872
Alireza Rasekhi, Haleh Bozorgi, Seyed Masoom Masoompour, Parviz Mardani, Mohammad Reza Azimi Aval
{"title":"Successful Sealing of Post-COVID-19 Bronchopleural Fistula with Computed Tomography Scan-Guided Percutaneous Cyanoacrylate Glue Injection: A Case Series.","authors":"Alireza Rasekhi, Haleh Bozorgi, Seyed Masoom Masoompour, Parviz Mardani, Mohammad Reza Azimi Aval","doi":"10.30476/IJMS.2023.97068.2872","DOIUrl":"10.30476/IJMS.2023.97068.2872","url":null,"abstract":"<p><p>Bronchopleural fistula (BPF), a sinus tract between the bronchial system and the pleural space, is associated with COVID-19 and can lead to pneumothorax, which increases the mortality rate. Due to the analytical status of COVID-19 patients, sealing the BPF necessitates the least minimal invasive treatment. Herein, we demonstrated a technique of sealing post-COVID-19 BPF with direct injection of cyanoacrylate glue under the guidance of a computed tomography scan. Following glue injection, the BPF was completely sealed in all four patients. In conclusion, in COVID-19 patients with small and distal BPF, percutaneous glue injection is recommended for BPF closure.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 2","pages":"130-133"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chlorogenic Acid Inhibits Progressive Pulmonary Fibrosis in a Diabetic Rat Model. 绿原酸抑制糖尿病大鼠模型中的进行性肺纤维化
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.96535.2868
Sagita Mega Sekar Kencana, Nur Arfian, Ratih Yuniartha, Ramadhea Laila Afifa An-Nur Willya Saputri, Fauziyatul Munawaroh, Dwi Cahyani Ratna Sari
{"title":"Chlorogenic Acid Inhibits Progressive Pulmonary Fibrosis in a Diabetic Rat Model.","authors":"Sagita Mega Sekar Kencana, Nur Arfian, Ratih Yuniartha, Ramadhea Laila Afifa An-Nur Willya Saputri, Fauziyatul Munawaroh, Dwi Cahyani Ratna Sari","doi":"10.30476/IJMS.2023.96535.2868","DOIUrl":"10.30476/IJMS.2023.96535.2868","url":null,"abstract":"<p><strong>Background: </strong>Chlorogenic acid (CGA) is known to have antifibrotic and hypoglycemic effects and may play a role in preventing diabetes-induced pulmonary fibrosis. This study aimed to determine the effect and optimum dose of CGA on diabetes-induced pulmonary fibrosis.</p><p><strong>Methods: </strong>Thirty Wistar rats (two-month-old, 150-200 grams) were randomly divided into six groups, namely control, six weeks diabetes mellitus (DM1), eight weeks DM (DM2), and three DM2 groups (CGA1, CGA2, and CGA3) who received CGA doses of 12.5, 25, and 50 mg/Kg BW, respectively. After six weeks, CGA was administered intraperitoneally for 14 consecutive days. Lung tissues were taken for TGF-β1, CTGF, SMAD7, Collagen-1, and α-SMA mRNA expression analysis and paraffin embedding. Data were analyzed using one-way ANOVA and the Kruskal-Wallis test. P<0.05 was considered statistically significant.</p><p><strong>Results: </strong>TGF-β1 expression in the CGA1 group (1.01±0.10) was lower than the DM1 (1.33±0.25, P=0.05) and DM2 (1.33±0.20, P=0.021) groups. α-SMA expression in the CGA1 group (median 0.60, IQR: 0.34-0.64) was lower than the DM1 (median 0.44, IQR: 0.42-0.80) and DM2 (median 0.76, IQR: 0.66-1.10) groups. Collagen-1 expression in the CGA1 group (0.75±0.13) was lower than the DM1 (P=0.24) and DM2 (P=0.26) groups, but not statistically significant. CTGF expression in CGA groups was lower than the DM groups (P=0.088), but not statistically significant. There was an increase in SMAD7 expression in CGA groups (P=0.286). Histological analysis showed fibrosis improvement in the CGA1 group compared to the DM groups.</p><p><strong>Conclusion: </strong>CGA (12.5 mg/Kg BW) inhibited the expression of profibrotic factors and increased antifibrotic factors in DM-induced rats.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 2","pages":"110-120"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytogenetic, Clinical, Hematologic, Demographic, Immunohistochemical, and Flow Cytometry Characteristics of Patients with Plasma Cell Neoplasm in Five Years: A First Report from Iran. 五年来浆细胞肿瘤患者的细胞遗传学、临床、血液学、人口统计学、免疫组化和流式细胞术特征:伊朗首次报告
IF 2.4
Iranian Journal of Medical Sciences Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.96892.2855
Mansoureh Shokripour, Seyed Ehsan Hosseini, Navid Omidifar, Maral Mokhtari, Akbar Safaei
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